OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 92. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	1002
Cap CASP, not SCAP, to fight steatohepatitis	668
Sex- and timing-specific effects of fasting and caloric restriction	605
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	571
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis	567
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	519
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	448
Unveiling adipose populations linked to metabolic health in obesity	430
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	408
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	397
The Achilles heel of TNBCs: Ferroptosis heterogeneity	362
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	293
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	283
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	278
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	260
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	258
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	246
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	236
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	232
Sugar addiction: An Achilles’ heel of auto-immune diseases?	227
Supercharging cancer-fighting T cells with lithium carbonate	226
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	219
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	218
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	213
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	206

Sphingolipid metabolism controls mammalian heart regeneration	201
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	199
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	199
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	182
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	177
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	177
The cephalic phase of insulin release is modulated by IL-1β	173
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	173
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	170
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	169
Mitochondrial membrane lipids in the regulation of bioenergetic flux	168
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	167
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	166
Nutrient allocation fuels T cell-mediated immunity	166
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	163
Focus on diet and exercise	161
Paraventricular glia drive circuit function to control metabolism	158
Targeting PDAC metabolism: Environment determines what has GOT2 give	149
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	149
Understanding the metabolism of infants using whole-body metabolic models	145
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	143
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	142
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	139
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes	139
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	138
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	137
Amino acid is a major carbon source for hepatic lipogenesis	136
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	133
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	133
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	132
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	131
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	131
Evaluating human genetic support for hypothesized metabolic disease genes	130
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	130
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	130
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	126
The crosstalk between bone remodeling and energy metabolism: A translational perspective	126
The past, present, and future physiology and pharmacology of glucagon	125
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	123
Digital twins for in vivo metabolic flux estimations in patients with brain cancer	121
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	121
Famsin and fasting adaptation: A glucagon connection	119
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	118
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	117
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	113
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	111
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	109
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	109
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	109
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	108

Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	107
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	104
Response to Paik et al. on the disease burden of NAFLD	103
Biting into a union of oncology and metabolism through leukemic stem cells	103
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	103
“Shunt-ing” down obesity with novel endogenous metabolites	101
Anti-seizure effects of norepinephrine-induced free fatty acid release	99
Liver microbes controlling immunity: Facts and pitfalls	99
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	97
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	97
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	96
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	95
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	95
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	94
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	93
Acetate enables metabolic fitness and cognitive performance during sleep disruption	92
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	92