OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 105. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	908
Cap CASP, not SCAP, to fight steatohepatitis	763
Breath volatilome as a non-invasive reflection of gut microbiota-driven health and disease	755
Sex- and timing-specific effects of fasting and caloric restriction	585
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	574
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis	535
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	464
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	416
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	385
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	378
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function	373
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	307
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	297
Unveiling adipose populations linked to metabolic health in obesity	284
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	282
The Achilles heel of TNBCs: Ferroptosis heterogeneity	276
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	267
The metabolic basis of regulated cell death	263
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	259
Polyunsaturated lipids kill senescent cells by ferroptosis	246
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	243
Supercharging cancer-fighting T cells with lithium carbonate	240
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	236
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	215
Oral GLP-1 receptor agonist promotes astrocyte-neuron lactate and lipid transfer with neuroprotective effects	215

Kir2.1 channel: Macrophage plasticity in tumor microenvironment	215
Illuminating the influence of natural daylight on human metabolism	213
FGF21 connects ER stress to sulfide signaling to enhance cellular resilience	208
Nutrient allocation fuels T cell-mediated immunity	206
Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11	193
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	191
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	188
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	188
Mitochondrial membrane lipids in the regulation of bioenergetic flux	187
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	185
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	182
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	181
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	176
Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice	175
Sphingolipid metabolism controls mammalian heart regeneration	174
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	172
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	170
Plasma proteomic signature of frailty in 50,506 adults	166
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	162
Understanding the metabolism of infants using whole-body metabolic models	160
The gut microbiota alleviates depression by remodeling gut-brain energy metabolism	159
Special packaging enables effective mitochondrial delivery	158
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	156
Targeting PDAC metabolism: Environment determines what has GOT2 give	149
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	147
Paraventricular glia drive circuit function to control metabolism	146
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	146
Focus on diet and exercise	145
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes	142
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	142
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	138
Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude	138
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	137
Gut microbiota and metabolic control of immune checkpoint blockade in cancer	136
Gut microbiota-derived deoxycholic acid shapes an immunosuppressive tumor microenvironment and promotes breast cancer progression	134
Lipid droplet-induced T cell death sustains autoimmune tissue inflammation	134
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	134
Digital twins for in vivo metabolic flux estimations in patients with brain cancer	133
Amino acid is a major carbon source for hepatic lipogenesis	133
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	132
Exercise as a therapeutic intervention for long-lasting and chronic diseases	132
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	132
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	131
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	131
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	130
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	130
The past, present, and future physiology and pharmacology of glucagon	128
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	127
“Shunt-ing” down obesity with novel endogenous metabolites	124
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	123

Famsin and fasting adaptation: A glucagon connection	123
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology	122
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	122
Mitochondrial lactate venting limits oxidative stress	121
Response to Paik et al. on the disease burden of NAFLD	119
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	119
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	119
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	118
Anti-seizure effects of norepinephrine-induced free fatty acid release	115
Dietary methionine mitigates immune-mediated damage by enhancing renal clearance of cytokines	114
Acetate enables metabolic fitness and cognitive performance during sleep disruption	113
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	113
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function	113
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	112
Emerging therapies in cancer metabolism	112
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	111
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	111
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	111
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	110
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	110
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	110
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer	109
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	108
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	108
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	108
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	108
Vitamin C slows primate aging by targeting iron-driven lipid peroxidation	107
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	107
Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport	105
Regulatory T cells thrive in ammonia-rich tumors	105
Missed signals: How PET imaging may fail to capture the addictive potential of ultra-processed foods	105