OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 99. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	831
Cap CASP, not SCAP, to fight steatohepatitis	716
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	675
Breath volatilome as a non-invasive reflection of gut microbiota-driven health and disease	554
The Achilles heel of TNBCs: Ferroptosis heterogeneity	531
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	508
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function	475
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	448
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	384
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	364
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	333
Sex- and timing-specific effects of fasting and caloric restriction	315
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	283
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	277
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	268
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	262
Unveiling adipose populations linked to metabolic health in obesity	252
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis	244
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	237
Polyunsaturated lipids kill senescent cells by ferroptosis	229
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	226
Nutrient allocation fuels T cell-mediated immunity	216
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	216
Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice	213
Illuminating the influence of natural daylight on human metabolism	212

A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	200
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	199
Supercharging cancer-fighting T cells with lithium carbonate	197
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	195
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	192
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	182
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	179
Sphingolipid metabolism controls mammalian heart regeneration	179
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	178
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	175
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	171
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	166
The cephalic phase of insulin release is modulated by IL-1β	166
Plasma proteomic signature of frailty in 50,506 adults	166
Mitochondrial membrane lipids in the regulation of bioenergetic flux	166
Targeting PDAC metabolism: Environment determines what has GOT2 give	163
The gut microbiota alleviates depression by remodeling gut-brain energy metabolism	162
Paraventricular glia drive circuit function to control metabolism	156
Focus on diet and exercise	156
Understanding the metabolism of infants using whole-body metabolic models	154
Lipid droplet-induced T cell death sustains autoimmune tissue inflammation	153
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	152
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	151
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	150
Gut microbiota-derived deoxycholic acid shapes an immunosuppressive tumor microenvironment and promotes breast cancer progression	150
Special packaging enables effective mitochondrial delivery	147
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes	144
Exercise as a therapeutic intervention for long-lasting and chronic diseases	138
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	133
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	133
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	129
Gut microbiota and metabolic control of immune checkpoint blockade in cancer	127
The past, present, and future physiology and pharmacology of glucagon	127
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	126
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	125
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	124
Digital twins for in vivo metabolic flux estimations in patients with brain cancer	124
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	124
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	124
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	123
Amino acid is a major carbon source for hepatic lipogenesis	121
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	121
Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude	121
The crosstalk between bone remodeling and energy metabolism: A translational perspective	119
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	118
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	118
Biting into a union of oncology and metabolism through leukemic stem cells	118
Response to Paik et al. on the disease burden of NAFLD	117
Dietary methionine mitigates immune-mediated damage by enhancing renal clearance of cytokines	116
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology	116

Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	114
“Shunt-ing” down obesity with novel endogenous metabolites	114
Famsin and fasting adaptation: A glucagon connection	114
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	113
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	112
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function	112
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	111
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	111
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	110
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	110
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	109
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	106
Acetate enables metabolic fitness and cognitive performance during sleep disruption	106
Mitochondrial lactate venting limits oxidative stress	106
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	103
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	103
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	103
Anti-seizure effects of norepinephrine-induced free fatty acid release	102
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	100
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	100
Emerging therapies in cancer metabolism	100
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	100
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	100
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	99
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	99
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity	99