OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 91. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Metabolic set points of mammalian neurodevelopment	614
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	521
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	374
Metabolic elasticity: A new measure of age	374
Microbial-host isozyme: A novel target in “drug the bug” strategies for diabetes	338
Death-seq and ye shall find: A novel screening strategy for dying cells	289
BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass	277
Reactive oxygen species regulation by NCF1 governs ferroptosis susceptibility of Kupffer cells to MASH	273
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening	262
A synaptic amplifier of hunger for regaining body weight in the hypothalamus	259
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	258
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	257
NAD precursors cycle between host tissues and the gut microbiome	250
Erythrocyte-derived mitochondria take to the lupus stage	243
Nourishing the mind: Fasting for brain health	243
Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration	241
Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila	233
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	232
Immunotherapy breaches low-sugar dieting of tumor Treg cells	223
Illuminating lactate in cells, mice, and patient samples	221
Diabesity? No worries, FKBP11 to the rescue	213
Methionine restriction forces Epstein-Barr virus out of latency	210
A new role for ammonia in tumorigenesis?	204
Cap CASP, not SCAP, to fight steatohepatitis	200
Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding	196

A glimpse at the metabolic research in China	193
Fight, flight, and freeze!	184
Passing on PCOS: new insights into its epigenetic transmission	182
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	173
Prevention of cardiorenal complications in people with type 2 diabetes and obesity	173
A hypometabolic defense strategy against malaria	170
Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis	165
Insulin: A GOAT of medical discovery	164
Global Spread of a Local Fire: Transmission of Endoplasmic Reticulum Stress via Connexin 43	164
Itaconate boosts malaria via induction of PD-L1	161
Hunger potentiated	160
The secret life of lactate: A novel cell-cycle regulatory mechanism	159
Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis	158
CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way	157
SARS-CoV-2 pirates the kidneys: A scar(y) story	156
A dietary source of antibiotic tolerance	152
Judith Campisi (1948–2024)	150
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	149
Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth	148
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	147
dNTP concentrations do not increase in mammalian cells in response to DNA damage	144
Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways	144
Nutrients in the fate of pluripotent stem cells	143
Mitochondrial quality control: Just walk away	141
A pattern emerges in chromatin aging: AP-1 steals the show	140
Meet the author: Professor Zhijian Cai	139
Unveiling adipose populations linked to metabolic health in obesity	139
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans	137
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging	135
Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1	133
The search for thermoregulatory neurons is heating up	129
Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience	128
Krebs takes a turn at cell differentiation	122
Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood	122
Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease	120
The Achilles heel of TNBCs: Ferroptosis heterogeneity	119
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise	119
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity	119
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss	115
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	115
Outrunning obesity with Lac-Phe?	114
Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression	113
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	112
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease	112
Electron transport chain inhibition increases cellular dependence on purine transport and salvage	109
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	109
Gene-metabolite linkage marks stored red blood cell quality	108
Bone marrow immune cells stop weight regain	108
CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression	107
A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1	106

Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer	106
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration	101
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma	99
Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist	98
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells	98
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	97
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	96
The role of hepatokines in NAFLD	96
Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow	96
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	96
The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas	95
What we talk about when we talk about spinal cord aging	95
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	93
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	92
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming	92
Formation of I2+III2 supercomplex rescues respiratory chain defects	91