OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 94. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	771
Cap CASP, not SCAP, to fight steatohepatitis	611
Sex- and timing-specific effects of fasting and caloric restriction	464
The Achilles heel of TNBCs: Ferroptosis heterogeneity	460
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	436
The search for thermoregulatory neurons is heating up	401
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	388
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	356
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	353
Unveiling adipose populations linked to metabolic health in obesity	343
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	342
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	313
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	311
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	307
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	297
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	290
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	282
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	280
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	265
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	262
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	258
The cephalic phase of insulin release is modulated by IL-1β	253
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis	231
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	222
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	211

Microvessels enhance vascularization and function of transplanted insulin-producing cells	210
Creatine promotes metastatic dissemination	205
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	189
Sugar addiction: An Achilles’ heel of auto-immune diseases?	189
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	189
Supercharging cancer-fighting T cells with lithium carbonate	187
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	187
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	187
Sphingolipid metabolism controls mammalian heart regeneration	182
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	181
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	175
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth	174
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	171
Mitochondrial membrane lipids in the regulation of bioenergetic flux	170
Adhesion-mediated mechanosignaling forces mitohormesis	169
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	165
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	162
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	161
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	161
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	160
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	154
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	153
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	150
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	150
Evaluating human genetic support for hypothesized metabolic disease genes	149
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	146
Amino acid is a major carbon source for hepatic lipogenesis	143
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	141
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	139
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	137
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	137
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	136
Understanding the metabolism of infants using whole-body metabolic models	135
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	134
Paraventricular glia drive circuit function to control metabolism	132
Focus on diet and exercise	127
Targeting PDAC metabolism: Environment determines what has GOT2 give	124
Mitochondria ensure immune surveillance by retro-communication with the nucleus	124
The crosstalk between bone remodeling and energy metabolism: A translational perspective	123
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	121
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	121
The past, present, and future physiology and pharmacology of glucagon	121
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	119
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	118
Exosomes as mediators of intercellular crosstalk in metabolism	117
Response to Paik et al. on the disease burden of NAFLD	116
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	116
Biting into a union of oncology and metabolism through leukemic stem cells	115
Anti-seizure effects of norepinephrine-induced free fatty acid release	114
Can tumor cells take it all away?	111

A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	111
Famsin and fasting adaptation: A glucagon connection	110
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	110
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	109
“Shunt-ing” down obesity with novel endogenous metabolites	109
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	108
Cardiovascular disease in diabetes, beyond glucose	107
Liver microbes controlling immunity: Facts and pitfalls	107
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	106
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	104
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	102
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	102
Emerging therapies in cancer metabolism	101
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	101
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	99
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	98
Acetate enables metabolic fitness and cognitive performance during sleep disruption	97
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	96
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	96
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	94