OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 95. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
The Metabolic Underpinnings of Ferroptosis	729
The hallmarks of cancer metabolism: Still emerging	541
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability	453
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity	335
Exosomes as mediators of intercellular crosstalk in metabolism	330
Why does obesity cause diabetes?	308
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets	264
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	260
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution	256
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment	254
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease	253
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer	236
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects	230
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism	227
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	226
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine	223
Gut-liver axis: Pathophysiological concepts and clinical implications	221
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	218
The global burden of metabolic disease: Data from 2000 to 2019	218
Mitochondrial signal transduction	211
Astrocyte-neuron metabolic cooperation shapes brain activity	210
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes	202
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells	197
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity	196
Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning	193

Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution	192
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis	189
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance	179
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy	176
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis	174
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice	168
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	165
Meta-hallmarks of aging and cancer	165
Mechanoresponsive metabolism in cancer cell migration and metastasis	161
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia	157
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion	157
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure	156
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling	154
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth	153
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	150
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer	149
Efferocytosis induces macrophage proliferation to help resolve tissue injury	145
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells	142
The role of lipids in cancer progression and metastasis	142
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2	140
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	140
High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis	139
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases	139
Molecular aspects of fructose metabolism and metabolic disease	139
Sphingolipids in metabolic disease: The good, the bad, and the unknown	139
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages	137
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19	136
Metabolic orchestration of the wound healing response	136
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease	135
Evolving concepts in NAD+ metabolism	134
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers	132
Immunometabolism in the Single-Cell Era	132
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment	131
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy	130
SARS-CoV-2 infection induces beta cell transdifferentiation	128
Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming	125
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process	125
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	124
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	120
Tryptophan metabolism in health and disease	120
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo	118
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue	118
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation	114
Hypothalamic detection of macronutrients via multiple gut-brain pathways	114
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	114
The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies	114
Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?	112
Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes	112
Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells	111
Cardiovascular disease in diabetes, beyond glucose	109

Microbiota alterations in proline metabolism impact depression	109
Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies	109
Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease	107
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis	106
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin	105
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	104
Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis	104
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway	103
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis	102
Hypothalamic bile acid-TGR5 signaling protects from obesity	102
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis	101
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity	99
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism	99
Biological age is increased by stress and restored upon recovery	97
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition	96
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication	96
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis	96
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis	96
Senescent immune cells release grancalcin to promote skeletal aging	95
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming	95