OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 99. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
The Metabolic Underpinnings of Ferroptosis	656
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis	486
The hallmarks of cancer metabolism: Still emerging	460
Benefits of Metformin in Attenuating the Hallmarks of Aging	411
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability	410
Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis	385
In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19	379
Mitochondrial Metabolism as a Target for Cancer Therapy	351
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation	344
The Role of HIF in Immunity and Inflammation	342
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation	313
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity	301
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity	298
Exosomes as mediators of intercellular crosstalk in metabolism	291
Amino Assets: How Amino Acids Support Immunity	277
The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study	255
Why does obesity cause diabetes?	246
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan	243
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets	240
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment	235
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	233
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution	230
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice	218
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism	215
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects	214

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition	211
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine	205
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer	202
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease	201
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	196
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation	194
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	194
Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning	190
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes	188
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells	187
Astrocyte-neuron metabolic cooperation shapes brain activity	182
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity	181
Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution	180
Quantitative Fluxomics of Circulating Metabolites	176
Gut-liver axis: Pathophysiological concepts and clinical implications	175
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress	175
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis	175
Mitochondrial signal transduction	170
The global burden of metabolic disease: Data from 2000 to 2019	168
The Gut Microbiota at the Service of Immunometabolism	163
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis	161
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance	160
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice	156
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion	147
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy	145
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure	145
Mechanoresponsive metabolism in cancer cell migration and metastasis	143
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling	142
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia	140
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	137
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells	137
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth	135
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	133
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19	133
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2	129
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer	128
A High-Density Human Mitochondrial Proximity Interaction Network	128
Sphingolipids in metabolic disease: The good, the bad, and the unknown	127
Molecular aspects of fructose metabolism and metabolic disease	125
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy	125
Efferocytosis induces macrophage proliferation to help resolve tissue injury	125
Evolving concepts in NAD+ metabolism	125
High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis	124
Meta-hallmarks of aging and cancer	124
Immunometabolism in the Single-Cell Era	124
SARS-CoV-2 infection induces beta cell transdifferentiation	123
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment	121
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers	120
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease	119
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases	119

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages	119
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process	118
Metabolic orchestration of the wound healing response	118
The role of lipids in cancer progression and metastasis	118
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis	118
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	116
Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage	116
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes	116
Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes	112
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo	107
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation	106
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue	106
The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies	105
Hypothalamic detection of macronutrients via multiple gut-brain pathways	104
Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming	103
Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain	103
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	103
Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease	103
Cardiovascular disease in diabetes, beyond glucose	102
Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?	101
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease	101
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin	99
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway	99
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	99
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis	99