OOIR: Observatory of International Research

Papers

(The median citation count of Rejuvenation Research is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Improved Neuroprotective Effects of Gallic Acid-Loaded Chitosan Nanoparticles Against Ischemic Stroke	39
MiR-151a-3p Promotes Postmenopausal Osteoporosis by Targeting SOCS5 and Activating JAK2/STAT3 Signaling	32
Perceptive–Cognitive and Physical Function in Prefrail Older Adults: Exergaming Versus Traditional Multicomponent Training	29
Are Japanese Older Adults Rejuvenating? Changes in Health-Related Measures Among Older Community Dwellers in the Last Decade	27
Decreased Levels of Anti-Aging Klotho in Obstructive Sleep Apnea	26
Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging	25
Intra-Articular Injections of a Whole Blood Clot Secretome, Autologous Conditioned Serum, Have Superior Clinical and Biochemical Efficacy Over Platelet-Rich Plasma and Induce Rejuvenation-Associated C	23
Associations Between Serum GDF15 Concentrations, Muscle Mass, and Strength Show Sex-Specific Differences in Older Hospital Patients	21
SIRT3 Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair	21
Dietary Intake of β-Glucans Can Prolong Lifespan and Exert an Antioxidant Action on Aged Fish Nothobranchius guentheri	17
Sociodemographic, Clinical and Functional Profile of Nonagenarians from Two Areas of Sardinia Characterized by Distinct Longevity Levels	16
Performance Declines Are Accelerated in the Oldest-Old Track and Field Athletes 80 to 94 Years of Age	15
Autophagy Plays a Role in the Prolongation of the Life Span of Caenorhabditis elegans by Astaxanthin	14
Effects of Guilingji on Aging Rats and Its Underlying Mechanisms	13
Handgrip Strength as a Complementary Test for Mobility Limitations Assessment in Acutely Hospitalized Oldest Old	13
Modulation of cGAS-STING Pathway by Nicotinamide Riboside in Alzheimer's Disease	12
Rutaecarpine Ameliorated High Sucrose-Induced Alzheimer's Disease Like Pathological and Cognitive Impairments in Mice	12
Correlation Between Telomere Length and Biomarkers of Oxidative Stress in Human Aging	12
Apple Extract (Malus sp.) and Rutin as Photochemopreventive Agents: Evaluation of Ultraviolet B-Induced Alterations on Skin Biopsies and Tissue-Engineered Skin	12
Plasma Proteomic Signature of Cellular Senescence and Markers of Biological Aging Among Postmenopausal Women	11
Effects of a High-Intensity Progressive-Cycle Program on Quality of Life and Motor Symptomatology in a Parkinson's Disease Population: A Pilot Randomized Controlled Trial	11
Combined Depression and Malnutrition As an Effective Predictor of First Fall Onset in a Chinese Community-Dwelling Population: A 2-Year Prospective Cohort Study	10
Is Blood Brain-Derived Neurotrophic Factor a Useful Biomarker to Monitor Mild Cognitive Impairment Patients?	10
Plasma from Young Rats Injected into Old Rats Induce Antiaging Effects	10
The Effects of Age and Fasting Models on Blood Pressure, Insulin/Glucose Profile, and Expression of Longevity Proteins in Male Rats	10

Astragaloside IV Extends Lifespan of Caenorhabditis elegans by Improving Age-Related Functional Declines and Triggering Antioxidant Responses	9
Shorter Leukocyte Telomere Lengths in Healthy Relatives of Patients with Coronary Heart Disease	9
Judgment Capacity, Fear of Falling, and the Risk of Falls in Community-Dwelling Older Adults: The Progetto Veneto Anziani Longitudinal Study	9
The Phenotypic Characterization of the Cammalleri Sisters, an Example of Exceptional Longevity	9
Valeriana fauriei Exerts Antidepressant-Like Effects Through Anti-inflammatory and Antioxidant Activities by Inhibiting Brain-Derived Neurotrophic Factor Associated with Chronic Restraint Stres	9
Rejuvenation Through Oxygen, More or Less	8
Contribution of Ferroptosis to Aging and Frailty	8
Advanced Age and Chronic Kidney Disease Modify the Association Between Metabolic Syndrome and Frailty Among Community-Dwelling Elderly	8
Role of Senescence and Neuroprotective Effects of Telomerase in Neurodegenerative Diseases	8
Glucosamine Displays a Potent Caloric Restriction Mimetic Effect in Senescent Rats by Activating Mitohormosis	7
Activation of CB1R-Dependent PGC-1α Is Involved in the Improved Mitochondrial Biogenesis Induced by Electroacupuncture Pretreatment	7
Link Between Senescence and Cell Fate: Senescence-Associated Secretory Phenotype and Its Effects on Stem Cell Fate Transition	7
Antiaging Vaccines Targeting Senescent Cells	7
¹H NMR-Based Fecal Metabolomics Reveals Changes in Gastrointestinal Function of Aging Rats Induced by d-Galactose	7
Three-Month Heterochronic Parabiosis Has a Deleterious Effect on the Lifespan of Young Animals, Without a Positive Effect for Old Animals	7
Supplementation with Brush Border Enzyme Alkaline Phosphatase Slows Aging	7
Natural Compounds as a Strategy to Optimize “In Vitro” Expansion of Stem Cells	6
Diet and Botanical Supplementation: Combination Therapy for Healthspan Improvement?	6
Zengye Decoction Ameliorates Insulin Resistance by Promoting Glucose Uptake	6
Angiotensin II-Induced Erythrocyte Senescence Contributes to Oxidative Stress	6
Topical Erythropoietin Accelerates Wound Closure in Patients with Diabetic Foot Ulcers: A Prospective, Multicenter, Single-Blind, Randomized, Controlled Trial	6
Berberine Ameliorates Lipopolysaccharide-Induced Cognitive Impairment Through SIRT1/NRF2/NF-κB Signaling Pathway in C57BL/6J Mice	6
Navitoclax (ABT-263) Rejuvenates Human Skin by Eliminating Senescent Dermal Fibroblasts in a Mouse/Human Chimeric Model	5
Beneficial Gut Microbiome Remodeled During Intermittent Fasting in Humans	5
The Neuroprotective Effects of Danggui-Shaoyao San on Vascular Cognitive Impairment: Involvement of the Role of the Low-Density Lipoprotein Receptor-Related Protein	5
Restoration of the Renin–Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models	5
Prevalence and Correlates of Statin Underuse for Secondary Prevention of Cardiovascular Disease in Older Adults 65–79 Years of Age: The Italian Health Examination Survey 2008–2012	5
The Traditional Formula Kai-Xin-San Alleviates Polyglutamine-Mediated Neurotoxicity by Modulating Proteostasis Network in Caenorhabditis elegans	5
CO₂ Fractional Laser Combined with 5-Fluorouracil Ethosomal Gel Treatment of Hypertrophic Scar Macro-, Microscopic, and Molecular Mechanism of Action in a Rabbit Animal Model	5
Cellular and Mitochondrial Quality Control Mechanisms in Maintaining Homeostasis in Aging	5
Dietary and Pharmacological Interventions That Inhibit Mammalian Target of Rapamycin Activity Alter the Brain Expression Levels of Neurogenic and Glial Markers in an Age-and Treatment-Dependent Manner	4
Cerebrovascular Rejuvenation: Novel Strategies for Prevention of Vascular Cognitive Impairment	4
Ageism Among Physicians and Nurses in Russia	4
Fluorescence-Based Detection of Ferrous Iron in Senescent Cells	4
It Is Time to Work on the Extension of Body Growth and Reproductive Stages	4
Response to the Thought-Provoking Critique of Hyperfunction Theory by Aubrey de Grey	4
Different Expression of Micro-RNA in the Subcutaneous and Visceral Adipose Tissue of Obese Subjects	4
Is the Leukocyte Telomere Length Associated with Decreased Physical Functional Capacity in the Elderly?	4
Gene–Environment Interaction of FOXO and Residential Greenness on Mortality Among Older Adults	4
COVID-19 as a Paradigmatic Model of the Heterogeneous Disease Presentation in Older People: Data from the GeroCovid Observational Study	4
Metformin Treatment in Old Rats and Effects on Mitochondrial Integrity	4
Carnosine Improves Cognitive Impairment Through Promoting SIRT6 Expression and Inhibiting Endoplasmic Reticulum Stress in a Diabetic Encephalopathy Model	4
Exercise Partially Rejuvenates Muscle Stem Cells	4
Mesenchymal Stem Cell in Mice Uterine and Its Therapeutic Effect on Osteoporosis	4
The Long-Term Benefits of a Multicomponent Physical Activity Program to Body Composition, Muscle Strength, Cardiorespiratory Capacity, and Bone Mineral Density in a Group of Nonagenarians	4
Astragalus Polysaccharide Alleviates Constipation in the Elderly Via Modification of Gut Microbiota and Fecal Metabolism	4
A Hypothesis: Fructosamine-3-Kinase-Related-Protein (FN3KRP) Catalyzes Deglycation of Maillard Intermediates Directly Downstream from Fructosamines	4
Lipid Hydrolase Enzymes: Pragmatic Prolongevity Targets for Improved Human Healthspan?	3
Leveraging Substrate Stiffness to Promote Stem Cell Asymmetric Division via Mechanotransduction–Polarity Protein Axis and Its Bayesian Regression Analysis	3
Ageism, Aging Anxiety, and Death and Dying Anxiety Among Doctors and Nurses	3

Chitosan Displays a Potent Caloric Restriction Mimetic Effect in Senescent Rats	3
Pan-Tissue Aging Clock Genes That Have Intimate Connections with the Immune System and Age-Related Disease	3
Hormetic Effect of 3-Bromopyruvate on Age-Induced Alterations in Erythrocyte Membrane Transporters and Oxidative Biomarkers in Rats	3
The Potential Role of Airways Periostin in the Clinical Practice of Patients Affected by Idiopathic Pulmonary Fibrosis	3
How Could We Slow or Reverse the Human Aging Process and Extend the Healthy Life Span with Heterochronous Autologous Hematopoietic Stem Cell Transplantation	3
Casein Hydrolysate Containing Milk-Derived Peptides Reduces Facial Pigmentation Partly by Decreasing Advanced Glycation End Products in the Skin: A Randomized Double-Blind Placebo-Controlled Trial	3
Kai-Xin-San Improves Cognitive Impairment via Wnt/β-Catenin and IRE1/XBP1s Signalings in APP/PS1 Mice	3
Identification of Apolipoprotein D as a Dermal Fibroblast Marker of Human Aging for Development of Skin Rejuvenation Therapy	3
1,25-Dihydroxyvitamin D and S-Klotho Plasma Levels: The Relationship Between Two Renal Antiaging Biomarkers Mediated by Bone Mineral Density in Middle-Aged Sedentary Adults	3
Neuroprotective Potential of Hydroalcoholic Extract of Centella asiatica Against 3-Nitropropionic Acid-Induced Huntington's Like Symptoms in Adult Zebrafish	3
Epigenetic Modifiers as Game Changers for Healthy Aging	2
Does Home-Based Exercise Improve the Physical Function of Prefrail Older Women?	2
Aqueous Extract from Astragalus membranaceus Can Improve the Function Degradation and Delay Aging on Drosophila melanogaster Through Antioxidant Mechanism	2
Eosinophils and White Fat: Protection from Worms and Inflammaging	2
T Cell Development and Function	2
Cryopreservation of a Human Brain and Its Experimental Correlate in Rats	2
Will Repeated Ablative Er:YAG Laser Treatment Sessions Cause Facial Skin Sensitivity? Results of a 12-Month, Prospective, Randomized Split-Face Study	2
Gazing Long into a Clinical and Social Abyss? Treating Hypertrophic Scarring and Keloids	2
SUMO Wrestles with Mitophagy to Extend Lifespan	2
Aging of the Suprachiasmatic Nucleus, CIRCLONSA Syndrome, Implications for Regenerative Medicine and Restoration of the Master Body Clock	2
Ultrastructural Characterization of Prolonged Normothermic and Cold Cerebral Ischemia in the Adult Rat	2
Programs, Hyperfunction, and Damage: Why Definitions and Logic Matter So Much in Biogerontology	2
Dietary Restriction Attenuates Inflammation and Protects Mouse Skin from High-Dose Ultraviolet B Irradiation	2
Effect of 12 Weeks of Resistance Training on Motor Coordination and Dynamic Balance of Older Woman	2
Metabolic Reprogramming Rejuvenates Aged Myeloid Cells Restoring Cognition	2
Effect of Long-Term Treatment with C₆₀ Fullerenes on the Lifespan and Health Status of CBA/Ca Mice	2
Using Modified Skin-Stretching Technique as an Alternative Solution for the Closure of Moderate and Extensive Skin Defects	2
Downregulation of SOX21-AS1 Alleviated Cisplatin Resistance in Cervical Cancer Through Epithelial–Mesenchymal Transition Inhibition	2
Mechanisms and Minimization of False Discovery of Metabolic Bioorthogonal Noncanonical Amino Acid Proteomics	2
Red Blood Cell Distribution Width Trajectory During a Multicomponent Exercise in Hospitalized Older Adults: A Secondary Analysis of a Randomized Clinical Trial	2