Nature Structural & Molecular Biology

Article	Citations
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	472
Author Correction: Polλ promotes microhomology-mediated end-joining	287
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site	239
Shifting our perspective on orphan G protein-coupled receptors	203
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	136
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	134
Protein import into mitochondria — a new path through the membranes	134
Snapshots of actin and tubulin folding inside the TRiC chaperonin	130
Accessible technology for diploid high-order 3D human genome analysis	110
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	96
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	93
Surviving under stress conditions	92
Structures of aberrant spliceosome intermediates on their way to disassembly	91
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	88
Towards a molecular and structural definition of cell death	83
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	83
P-type ATPase magnesium transporter MgtA acts as a dimer	81
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization	80
A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients	79
Structural insights into translocation and tailored synthesis of hyaluronan	78
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism	78
Exploration of novel αβ-protein folds through de novo design	78
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	76
Endocrine resistance and breast cancer plasticity are controlled by CoREST	74
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	73

Structural basis of branching during RNA splicing	72
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation	68
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	67
Structural insights into metazoan pretargeting GET complexes	66
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	66
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	65
The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	65
Current challenges in understanding the role of enhancers in disease	65
Constitutive activation mechanism of a class C GPCR	62
30 years of structural and molecular biology and counting	62
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	60
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	59
Transcription directionality is licensed by Integrator at active human promoters	58
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	58
Structure of the HCV glycoprotein	58
Studying the impact of the nuclear topography on gene function	57
Binding NEMO: Liquid–liquid phase separation captures immune regulator	57
EGOC inhibits TOROID polymerization by structurally activating TORC1	56
Cohesin closes the door on coexpression	55
Author Correction: Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	54
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM	54
Author Correction: Cryo-EM structure of an active central apparatus	54
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex	54
Phase separation drives X-chromosome inactivation	53
SCAF1 drives the compositional diversity of mammalian respirasomes	53
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes	53
Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo	52
Smc5/6 silences episomal transcription by a three-step function	52
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics	52
Understanding ubiquitination in neurodevelopment by integrating insights across space and time	52
Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport	51
Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development	51
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	51
Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair	50
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	50
A personal perspective of the voltage-gated potassium channel studies	50
THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development	50
Building insights into KRAS signaling complexes	50
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	50
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	49
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	49
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers	48
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates	48
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation	48
Structures of transcription preinitiation complex engaged with the +1 nucleosome	47
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells	47
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	47
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	47
Better SIFI than sorry	47
The conformational landscape of human transthyretin revealed by cryo-EM	46

Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	45
Control of transcription elongation and DNA repair by alarmone ppGpp	45
Cryo-EM structure of an active central apparatus	44
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos	44
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution	44
Transport mechanism of presynaptic high-affinity choline uptake by CHT1	43
Transcription modulates chromatin dynamics and locus configuration sampling	43
Functional epigenomics: chromatin complexity untangled	43
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization	43
Virtual screen raises hit rate	43
Perfect match: PET ligand fits snugly into folded Tau filaments	43
All roads lead to MRN regulation at telomeres: different paths to one solution	42
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure	42
Thirty years of structural changes	42
Transcription and replication meet the silent X chromosome territory	42
Structural basis of circularly permuted group II intron self-splicing	41
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly	41
Finding and recycling stalled spliceosomes	41
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation	41
STING to the lysosome’s rescue	41
Structural basis for the dynamic chaperoning of disordered clients by Hsp90	40
Structure and function of the human mitochondrial MRS2 channel	40
Diverse activation mechanisms of PI3Ks	40
Evolution of a histone variant involved in compartmental regulation of NAD metabolism	39
The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes	39
The coupling mechanism of mammalian mitochondrial complex I	39
TALEDs complete the toolkit for editing human mitochondrial DNA	39
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)	39
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants	39
Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1	38
Structure and interactions of the endogenous human Commander complex	38
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads	37
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies	37
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation	36
CENP-N promotes the compaction of centromeric chromatin	36
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening	36
ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network	36
Cryptic elements of the heat-shock response	35
Structural basis of hepatitis B virus receptor binding	35
Looking back at 2021	35
MacroH2A1.1 has evolved to let PARP1 do more by loosening its grip on PAR	35
DNA replication at high res	35
Hallucination of closed repeat proteins containing central pockets	34
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans	34
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC	34
Regulatory activity is the default DNA state in eukaryotes	34
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus	34
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase	33
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis	33
Structural clues about bridge-mediated lipid transfer	33
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	33
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37	33
Two dynamically competing factors determine the translation start site	33
Cryo-EM structures of human RNA polymerase I	33
Structure of RAS signaling regulator complex reveals mechanism	32
Structure of a volume-regulated heteromeric LRRC8A/C channel	32
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	32
Molting mitochondria	32
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development	32
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling	32
Looking back at 30 years of Nature Structural & Molecular Biology	32
Structural insights into the iron nitrogenase complex	32
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine	32
Structural basis of pH-dependent activation in a CLC transporter	31
De novo design of obligate ABC-type heterotrimeric proteins	31
Mechanical disengagement of the cohesin ring	31
A chromatin mesh model for compaction of chromatin by PRC1 in condensates	31
A nanobody-based therapeutic targeting Nipah virus limits viral escape	31
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis	31
Molecular basis of the TRAP complex function in ER protein biogenesis	31
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase	30
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1	30
Parkinson’s disease risk protein TMEM175 keeps lysosomes running on a proton leak	30
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	30
PARP1 and HPF1 team up to flag down DNA-repair machinery	30
Structure and function of a broad-range thermal receptor in myriapods	30
Ferlin structures	30
Distinct tau filament folds in human MAPT mutants P301L and P301T	30
The structure of the NuA4–Tip60 complex reveals the mechanism and importance of long-range chromatin modification	30
Mechanisms for licensing origins of DNA replication in eukaryotic cells	29

Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides	29
A tweak and a peek: How Cas9 pries open double-stranded DNA to check its sequence	29
Remote on–off switching of protein activity by intrinsically disordered region	29
The yeast genome is globally accessible in living cells	29
Author Correction: Smc5/6 silences episomal transcription by a three-step function	28
Replication licensing during S phase: breaking the law to prevent breaking DNA	28
Menopause age and cancer risk is influenced by rare genetic variants	28
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis	28
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss	28
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence	28
Mapping the conformational landscape of the stimulatory heterotrimeric G protein	28
Actin up: shifting chromosomes toward repair, but also translocations	28
Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta	28
Cryo-EM structures of the Spo11 core complex bound to DNA	28
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex	28
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets	27
Author Correction: Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation	27
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA	27
Mechanism of mammalian transcriptional repression by noncoding RNA	27
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing	27
Returning home to navigate challenges and meet potential in Poland	27
Structural insights into the regulation of Cas7-11 by TPR-CHAT	27
Towards a structurally resolved human protein interaction network	27
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication	27
Regulation of kinesin-2 motility by its β-hairpin motif	27
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1	27
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells	26
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation	26
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity	26
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins	26
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W	26
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia	26
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor	26
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate	25
How one molecule senses light and temperature	25
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	25
A unifying model for membrane protein biogenesis	25
Exposing chromothripsis	25
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function	25
Structural insights into TRPV2 modulation by probenecid	25
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	25
Neuronal VPS13D loss drives microglial activation	25
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families	25
Building a molecular rotor	25
Space exploration: finding new protein conformations using AlphaFold2	25
An egg-ceptional mechanism of acentrosomal spindle assembly	25
A conformational switch controlling the toxicity of the prion protein	24
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	24
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	24
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	24
Computational design of sequence-specific DNA-binding proteins	24
Structure of the γ-tubulin ring complex-capped microtubule	24
Structural basis for CaVα2δ:gabapentin binding	24
Plasticity in ligand recognition at somatostatin receptors	24
The molecular basis of lamin-specific chromatin interactions	24
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	23
Ebola virus L–VP35 structure	23
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals	23
Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis	23
Human primase hangs on the primer–template and Polα to facilitate primer termination	23
Cracking the case of m7G modification in human tRNAs	23
Building up complexity in structural biology studies	23
A snapshot of proteostasis in human oocytes	23
Structural insights into SV2A and the mechanism of racetam anticonvulsants	23
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	23
From atoms to cells	23
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	23
Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels	23
AlphaFold3 takes a step toward decoding molecular behavior and biological computation	22
Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome	22
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation	22
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair	22
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor	22
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling	22
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase	22
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	22
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	22
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis	22
Future opportunities in solute carrier structural biology	22
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis	22
Architecture of the ESCPE-1 membrane coat	22
Decoupling of degradation from deadenylation reshapes poly(A) tail length in yeast meiosis	22
Natural selection finds a way, even under heavy constraints	22
The RNA world	21
Membrane-embedded machines	21
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state	21
An in vivo platform to screen for regulators of Huntington’s disease	21
The impact of DNA methylation on CTCF-mediated 3D genome organization	21
The essential functions of protein SUMOylation in cell proliferation	21
ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility	21
Quantitative analysis of transcription start site selection reveals control by DNA sequence, RNA polymerase II activity and NTP levels	21
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation	21
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1	21
Higher-order phosphatase–substrate contacts terminate the integrated stress response	21
Looking back at 2023	21