Nature Structural & Molecular Biology

Article	Citations
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects	419
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2	387
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation	370
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis	355
Controlling the SARS-CoV-2 spike glycoprotein conformation	327
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur	311
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers	247
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient	244
A thermostable, closed SARS-CoV-2 spike protein trimer	225
Histone lysine methyltransferases in biology and disease	209
Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion	200
An ultra high-throughput method for single-cell joint analysis of open chromatin and transcriptome	199
Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors	199
Enhancer RNAs are an important regulatory layer of the epigenome	172
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A	160
UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor	154
A structural biology community assessment of AlphaFold2 applications	142
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs	139
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation	137
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation	133
Bromodomain biology and drug discovery	129
AlphaFold2 and the future of structural biology	128
Structural basis for broad coronavirus neutralization	123
Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex	120
Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs	112

Can AlphaFold2 predict the impact of missense mutations on structure?	109
Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution	105
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function	105
Cryo-EM structure of the entire mammalian F-type ATP synthase	103
Mechanism of ribosome stalling during translation of a poly(A) tail	102
Molnupiravir: coding for catastrophe	96
Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils	96
Multivalent interactions between CsoS2 and Rubisco mediate α-carboxysome formation	94
Cryo-EM structure of an amyloid fibril formed by full-length human prion protein	94
Targeted protein degradation as a powerful research tool in basic biology and drug target discovery	93
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent	91
Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation	90
PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia	88
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin	87
The molecular structure of mammalian primary cilia revealed by cryo-electron tomography	86
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function	86
Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation	84
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies	83
RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1	82
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils	81
Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism	78
Decoding mRNA translatability and stability from the 5′ UTR	78
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation	77
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease	76
G-tract RNA removes Polycomb repressive complex 2 from genes	76
Beads on a string—nucleosome array arrangements and folding of the chromatin fiber	74
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS	73
Cryo-EM structures of the ATP release channel pannexin 1	73
Molecular mechanism for rotational switching of the bacterial flagellar motor	72
FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair	71
Structural basis of temperature sensation by the TRP channel TRPV3	71
Structures of radial spokes and associated complexes important for ciliary motility	69
Single-gene imaging links genome topology, promoter–enhancer communication and transcription control	69
Roles of the BRD4 short isoform in phase separation and active gene transcription	67
GPCR activation mechanisms across classes and macro/microscales	66
Membrane constriction and thinning by sequential ESCRT-III polymerization	66
Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core	66
Dnmt1 has de novo activity targeted to transposable elements	65
Heat-dependent opening of TRPV1 in the presence of capsaicin	65
It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation	61
Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly	61
Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication	60
Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs	60
Structure of the human lipid exporter ABCB4 in a lipid environment	60
Cryo-EM structure of the ClpXP protein degradation machinery	59
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel	59
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome	57
Cold sensitivity of the SARS-CoV-2 spike ectodomain	57
An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections	57
Structural basis of nucleosome transcription mediated by Chd1 and FACT	56

Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization	55
Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics	55
Reconstitution of translesion synthesis reveals a mechanism of eukaryotic DNA replication restart	54
Dimers of DNA-PK create a stage for DNA double-strand break repair	54
RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome	53
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity	51
Structure and assembly of calcium homeostasis modulator proteins	50
Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly	50
Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR	50
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads	49
BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells	49
The oligomeric structures of plant cryptochromes	49
Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression	49
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states	49
Structural insights into the regulation of human serine palmitoyltransferase complexes	48
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes	48
Multi-contact 3C reveals that the human genome during interphase is largely not entangled	48
The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism	47
Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles	47
Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs	46
Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis	46
A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair	46
Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism	46
Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex	46
The condensin holocomplex cycles dynamically between open and collapsed states	46
BAK core dimers bind lipids and can be bridged by them	45
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1	45
Endogenous retroviruses drive species-specific germline transcriptomes in mammals	45
Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions	44
Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments	44
Structure of H3K36-methylated nucleosome–PWWP complex reveals multivalent cross-gyre binding	44
A bipartite structural organization defines the SERINC family of HIV-1 restriction factors	44
The case for post-predictional modifications in the AlphaFold Protein Structure Database	43
Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks	42
Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development	42
Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB	42
Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation	41
SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly	41
Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state	40
Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex	40
Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription	40
Targeting non-bromodomain chromatin readers	40
Mechanistic insight into substrate processing and allosteric inhibition of human p97	39
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism	39
The structure of the cohesin ATPase elucidates the mechanism of SMC–kleisin ring opening	39
Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily	39
The three-dimensional structure of human β-endorphin amyloid fibrils	39
Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme	39
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency	39
Gating of human TRPV3 in a lipid bilayer	39
Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis	38
The structural basis of fatty acid elongation by the ELOVL elongases	38
Large-scale tethered function assays identify factors that regulate mRNA stability and translation	38
DNA-loop-extruding SMC complexes can traverse one another in vivo	38
Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis	37
FACT mediates cohesin function on chromatin	37
Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A	37
Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody	37
Structural basis of CD4 downregulation by HIV-1 Nef	37
Mechanism of ligand activation of a eukaryotic cyclic nucleotide−gated channel	37
Retinoic acid signaling is critical during the totipotency window in early mammalian development	36
A structural model of a Ras–Raf signalosome	36
The structure and oxidation of the eye lens chaperone αA-crystallin	36
Cryo-EM structures of Toll-like receptors in complex with UNC93B1	36
TET2 chemically modifies tRNAs and regulates tRNA fragment levels	35
X-chromosome upregulation is driven by increased burst frequency	35
Structural basis for STAT2 suppression by flavivirus NS5	35
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution	35
Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment	35
DNA interference states of the hypercompact CRISPR–CasΦ effector	35
Target-induced clustering activates Trim-Away of pathogens and proteins	34
Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2	34
Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62	34
Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating	34
PARP inhibition impedes the maturation of nascent DNA strands during DNA replication	34
Multiple direct interactions of TBP with the MYC oncoprotein	34
Towards a structurally resolved human protein interaction network	34
Structural insights into transcriptional regulation of human RNA polymerase III	34
The coupling mechanism of mammalian mitochondrial complex I	33
Cryo-EM structure of the Hippo signaling integrator human STRIPAK	33

CRISPR–Cas9 bends and twists DNA to read its sequence	33
Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity	33
A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission	33
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9	33
The structure of a virus-encoded nucleosome	33
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes	32
Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture	32
Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein	32
Reprogramming of the histone H3.3 landscape in the early mouse embryo	32
Molecular basis for kinin selectivity and activation of the human bradykinin receptors	32
Conformational buffering underlies functional selection in intrinsically disordered protein regions	32
Quantification of translation uncovers the functions of the alternative transcriptome	31
Viral hijacking of the TENT4–ZCCHC14 complex protects viral RNAs via mixed tailing	31
SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations	31
Regulation of translation by site-specific ribosomal RNA methylation	31
irCLASH reveals RNA substrates recognized by human ADARs	31
Structural and functional characterization of the Spo11 core complex	31
Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein	30
Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease	30
Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry	30
A structurally minimized yet fully active insulin based on cone-snail venom insulin principles	30
Structural basis for RNA polymerase III transcription repression by Maf1	30
InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1–SMG8–SMG9 complex	29
Conservative transcription in three steps visualized in a double-stranded RNA virus	29
Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition	29
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores	28
Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes	28
Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate	28
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation	28
Structure of a P element transposase–DNA complex reveals unusual DNA structures and GTP-DNA contacts	28
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	28
Structural basis of RNA processing by human mitochondrial RNase P	28
mRNA structural dynamics shape Argonaute-target interactions	27
Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins	27
Structures of mouse DUOX1–DUOXA1 provide mechanistic insights into enzyme activation and regulation	27
Torque transmission mechanism of the curved bacterial flagellar hook revealed by cryo-EM	27
Structural basis for ribosome recycling by RRF and tRNA	27
Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release	27
Chemical RNA digestion enables robust RNA-binding site mapping at single amino acid resolution	26
CENP-N promotes the compaction of centromeric chromatin	26
Synergistic activation of the insulin receptor via two distinct sites	26
H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage	26
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome	26