Nature Structural & Molecular Biology

(The TQCC of Nature Structural & Molecular Biology is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects419
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2387
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation370
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis355
Controlling the SARS-CoV-2 spike glycoprotein conformation327
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur311
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers247
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient244
A thermostable, closed SARS-CoV-2 spike protein trimer225
Histone lysine methyltransferases in biology and disease209
Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion200
An ultra high-throughput method for single-cell joint analysis of open chromatin and transcriptome199
Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors199
Enhancer RNAs are an important regulatory layer of the epigenome172
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A160
UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor154
A structural biology community assessment of AlphaFold2 applications142
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs139
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation137
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation133
Bromodomain biology and drug discovery129
AlphaFold2 and the future of structural biology128
Structural basis for broad coronavirus neutralization123
Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex120
Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs112
Can AlphaFold2 predict the impact of missense mutations on structure?109
Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution105
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function105
Cryo-EM structure of the entire mammalian F-type ATP synthase103
Mechanism of ribosome stalling during translation of a poly(A) tail102
Molnupiravir: coding for catastrophe96
Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils96
Multivalent interactions between CsoS2 and Rubisco mediate α-carboxysome formation94
Cryo-EM structure of an amyloid fibril formed by full-length human prion protein94
Targeted protein degradation as a powerful research tool in basic biology and drug target discovery93
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent91
Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation90
PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia88
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin87
The molecular structure of mammalian primary cilia revealed by cryo-electron tomography86
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function86
Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation84
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies83
RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD182
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils81
Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism78
Decoding mRNA translatability and stability from the 5′ UTR78
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation77
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease76
G-tract RNA removes Polycomb repressive complex 2 from genes76
Beads on a string—nucleosome array arrangements and folding of the chromatin fiber74
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS73
Cryo-EM structures of the ATP release channel pannexin 173
Molecular mechanism for rotational switching of the bacterial flagellar motor72
FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair71
Structural basis of temperature sensation by the TRP channel TRPV371
Structures of radial spokes and associated complexes important for ciliary motility69
Single-gene imaging links genome topology, promoter–enhancer communication and transcription control69
Roles of the BRD4 short isoform in phase separation and active gene transcription67
GPCR activation mechanisms across classes and macro/microscales66
Membrane constriction and thinning by sequential ESCRT-III polymerization66
Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core66
Dnmt1 has de novo activity targeted to transposable elements65
Heat-dependent opening of TRPV1 in the presence of capsaicin65
It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation61
Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly61
Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication60
Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs60
Structure of the human lipid exporter ABCB4 in a lipid environment60
Cryo-EM structure of the ClpXP protein degradation machinery59
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel59
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome57
Cold sensitivity of the SARS-CoV-2 spike ectodomain57
An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections57
Structural basis of nucleosome transcription mediated by Chd1 and FACT56
Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization55
Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics55
Reconstitution of translesion synthesis reveals a mechanism of eukaryotic DNA replication restart54
Dimers of DNA-PK create a stage for DNA double-strand break repair54
RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome53
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity51
Structure and assembly of calcium homeostasis modulator proteins50
Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly50
Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR50
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads49
BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells49
The oligomeric structures of plant cryptochromes49
Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression49
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states49
Structural insights into the regulation of human serine palmitoyltransferase complexes48
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes48
Multi-contact 3C reveals that the human genome during interphase is largely not entangled48
The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism47
Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles47
Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs46
Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis46
A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair46
Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism46
Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex46
The condensin holocomplex cycles dynamically between open and collapsed states46
BAK core dimers bind lipids and can be bridged by them45
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD145
Endogenous retroviruses drive species-specific germline transcriptomes in mammals45
Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions44
Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments44
Structure of H3K36-methylated nucleosome–PWWP complex reveals multivalent cross-gyre binding44
A bipartite structural organization defines the SERINC family of HIV-1 restriction factors44
The case for post-predictional modifications in the AlphaFold Protein Structure Database43
Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks42
Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development42
Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB42
Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation41
SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly41
Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state40
Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex40
Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription40
Targeting non-bromodomain chromatin readers40
Mechanistic insight into substrate processing and allosteric inhibition of human p9739
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism39
The structure of the cohesin ATPase elucidates the mechanism of SMC–kleisin ring opening39
Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily39
The three-dimensional structure of human β-endorphin amyloid fibrils39
Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme39
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency39
Gating of human TRPV3 in a lipid bilayer39
Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis38
The structural basis of fatty acid elongation by the ELOVL elongases38
Large-scale tethered function assays identify factors that regulate mRNA stability and translation38
DNA-loop-extruding SMC complexes can traverse one another in vivo38
Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis37
FACT mediates cohesin function on chromatin37
Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A37
Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody37
Structural basis of CD4 downregulation by HIV-1 Nef37
Mechanism of ligand activation of a eukaryotic cyclic nucleotide−gated channel37
Retinoic acid signaling is critical during the totipotency window in early mammalian development36
A structural model of a Ras–Raf signalosome36
The structure and oxidation of the eye lens chaperone αA-crystallin36
Cryo-EM structures of Toll-like receptors in complex with UNC93B136
TET2 chemically modifies tRNAs and regulates tRNA fragment levels35
X-chromosome upregulation is driven by increased burst frequency35
Structural basis for STAT2 suppression by flavivirus NS535
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution35
Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment35
DNA interference states of the hypercompact CRISPR–CasΦ effector35
Target-induced clustering activates Trim-Away of pathogens and proteins34
Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 234
Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec6234
Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating34
PARP inhibition impedes the maturation of nascent DNA strands during DNA replication34
Multiple direct interactions of TBP with the MYC oncoprotein34
Towards a structurally resolved human protein interaction network34
Structural insights into transcriptional regulation of human RNA polymerase III34
The coupling mechanism of mammalian mitochondrial complex I33
Cryo-EM structure of the Hippo signaling integrator human STRIPAK33
CRISPR–Cas9 bends and twists DNA to read its sequence33
Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity33
A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission33
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A933
The structure of a virus-encoded nucleosome33
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes32
Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture32
Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein32
Reprogramming of the histone H3.3 landscape in the early mouse embryo32
Molecular basis for kinin selectivity and activation of the human bradykinin receptors32
Conformational buffering underlies functional selection in intrinsically disordered protein regions32
Quantification of translation uncovers the functions of the alternative transcriptome31
Viral hijacking of the TENT4–ZCCHC14 complex protects viral RNAs via mixed tailing31
SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations31
Regulation of translation by site-specific ribosomal RNA methylation31
irCLASH reveals RNA substrates recognized by human ADARs31
Structural and functional characterization of the Spo11 core complex31
Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein30
Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease30
Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry30
A structurally minimized yet fully active insulin based on cone-snail venom insulin principles30
Structural basis for RNA polymerase III transcription repression by Maf130
InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1–SMG8–SMG9 complex29
Conservative transcription in three steps visualized in a double-stranded RNA virus29
Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition29
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores28
Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes28
Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate28
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation28
Structure of a P element transposase–DNA complex reveals unusual DNA structures and GTP-DNA contacts28
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state28
Structural basis of RNA processing by human mitochondrial RNase P28
mRNA structural dynamics shape Argonaute-target interactions27
Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins27
Structures of mouse DUOX1–DUOXA1 provide mechanistic insights into enzyme activation and regulation27
Torque transmission mechanism of the curved bacterial flagellar hook revealed by cryo-EM27
Structural basis for ribosome recycling by RRF and tRNA27
Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release27
Chemical RNA digestion enables robust RNA-binding site mapping at single amino acid resolution26
CENP-N promotes the compaction of centromeric chromatin26
Synergistic activation of the insulin receptor via two distinct sites26
H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage26
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome26