Nature Structural & Molecular Biology

Article	Citations
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	602
Surviving under stress conditions	242
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	167
30 years of structural and molecular biology and counting	145
Structure of the HCV glycoprotein	122
Shifting our perspective on orphan G protein-coupled receptors	121
The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	116
Gene regulation through exon junction complex modularity	110
Protein import into mitochondria — a new path through the membranes	107
Author Correction: Polλ promotes microhomology-mediated end-joining	104
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	98
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site	97
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	95
Author Correction: Structure and mechanism of antiphage retron Eco2	93
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism	93
Charting the 3D regulatory landscape of sex determination with geostatistics	92
Structural basis of branching during RNA splicing	85
Structures of aberrant spliceosome intermediates on their way to disassembly	79
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	78
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	78
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	77
Constitutive activation mechanism of a class C GPCR	77
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	74
Accessible technology for diploid high-order 3D human genome analysis	73
Towards a molecular and structural definition of cell death	72

A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	69
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	69
Current challenges in understanding the role of enhancers in disease	69
A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients	69
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization	69
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	69
Exploration of novel αβ-protein folds through de novo design	69
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	68
Endocrine resistance and breast cancer plasticity are controlled by CoREST	65
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	65
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	65
Yolk transports miRNAs to embryos and enhances progeny stress resilience	64
Transcription directionality is licensed by Integrator at active human promoters	64
Structural insights into translocation and tailored synthesis of hyaluronan	64
P-type ATPase magnesium transporter MgtA acts as a dimer	63
Binding NEMO: Liquid–liquid phase separation captures immune regulator	62
A personal perspective of the voltage-gated potassium channel studies	61
Cohesin closes the door on coexpression	61
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	61
Studying the impact of the nuclear topography on gene function	61
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells	60
MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy	60
THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development	59
Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development	58
Smc5/6 silences episomal transcription by a three-step function	58
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	57
The conformational landscape of human transthyretin revealed by cryo-EM	57
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	56
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates	55
EGOC inhibits TOROID polymerization by structurally activating TORC1	55
Better SIFI than sorry	55
Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo	55
Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex	53
Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport	53
SCAF1 drives the compositional diversity of mammalian respirasomes	53
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos	52
Control of transcription elongation and DNA repair by alarmone ppGpp	51
Understanding ubiquitination in neurodevelopment by integrating insights across space and time	51
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes	50
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers	50
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM	50
Function and regulation of the mitochondrial stress response	49
Structures of transcription preinitiation complex engaged with the +1 nucleosome	49
Checking in on proteostasis	49
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	49
Author Correction: Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	48
Author Correction: Cryo-EM structure of an active central apparatus	48
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	47
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	47
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex	47

Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	47
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation	46
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	46
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics	45
Virtual screen raises hit rate	45
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution	45
Perfect match: PET ligand fits snugly into folded Tau filaments	45
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure	44
Functional epigenomics: chromatin complexity untangled	44
Thirty years of structural changes	44
STING to the lysosome’s rescue	44
Transcription and replication meet the silent X chromosome territory	44
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening	44
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly	43
Structural basis of circularly permuted group II intron self-splicing	43
Transport mechanism of presynaptic high-affinity choline uptake by CHT1	43
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization	43
All roads lead to MRN regulation at telomeres: different paths to one solution	42
Structure and function of the human mitochondrial MRS2 channel	42
Structural basis of hepatitis B virus receptor binding	42
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation	41
Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1	41
Structural basis for the dynamic chaperoning of disordered clients by Hsp90	41
Finding and recycling stalled spliceosomes	41
Structure and interactions of the endogenous human Commander complex	40
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies	40
ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network	40
Transcription modulates chromatin dynamics and locus configuration sampling	39
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation	39
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants	39
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)	39
Dynamics of microcompartment formation at the mitosis-to-G1 transition	39
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development	38
Structural clues about bridge-mediated lipid transfer	38
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus	38
Two dynamically competing factors determine the translation start site	38
MitoPerturb-Seq identifies links between nuclear and mitochondrial genomes in single cells	37
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	37
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans	37
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling	37
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine	37
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37	37
Structure of a volume-regulated heteromeric LRRC8A/C channel	37
Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed	37
Structural insights into the iron nitrogenase complex	37
Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs	36
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis	36
Hallucination of closed repeat proteins containing central pockets	36
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	36
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC	36
Structure and function of a broad-range thermal receptor in myriapods	35
Parkinson’s disease risk protein TMEM175 keeps lysosomes running on a proton leak	35
Regulatory activity is the default DNA state in eukaryotes	35
Ferlin structures	35
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis	35
The structure of the NuA4–Tip60 complex reveals the mechanism and importance of long-range chromatin modification	35
Looking back at 30 years of Nature Structural & Molecular Biology	35
PARP1 and HPF1 team up to flag down DNA-repair machinery	35
A chromatin mesh model for compaction of chromatin by PRC1 in condensates	35
Structure of RAS signaling regulator complex reveals mechanism	35
Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity	34
Remote on–off switching of protein activity by intrinsically disordered region	34
EMProt improves structure determination from cryo-EM maps	34
De novo design of obligate ABC-type heterotrimeric proteins	33
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase	33
A nanobody-based therapeutic targeting Nipah virus limits viral escape	33
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1	33
The yeast genome is globally accessible in living cells	33
Mechanisms for licensing origins of DNA replication in eukaryotic cells	33
Mechanical disengagement of the cohesin ring	33
Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides	32
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss	32
Menopause age and cancer risk is influenced by rare genetic variants	32
Actin up: shifting chromosomes toward repair, but also translocations	32
Structural basis of pH-dependent activation in a CLC transporter	32
Molecular basis of the TRAP complex function in ER protein biogenesis	32
Returning home to navigate challenges and meet potential in Poland	32
Distinct tau filament folds in human MAPT mutants P301L and P301T	32
Mechanism and reconstitution of circadian transcription in cyanobacteria	32
Replication licensing during S phase: breaking the law to prevent breaking DNA	32

Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence	32
Extending guide RNA length restores high-fidelity CRISPR–Cas9 activity	31
Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta	31
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing	31
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia	31
Kinetic control of mammalian transcription elongation	31
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W	31
Mechanism of mammalian transcriptional repression by noncoding RNA	31
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication	31
Author Correction: Smc5/6 silences episomal transcription by a three-step function	31
TMEM170 proteins are lipid scramblases associated with bridge-type lipid transporters BLTP1/Csf1	31
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets	31
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate	31
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis	31
Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types	30
Cryo-EM structures of the Spo11 core complex bound to DNA	30
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells	30
How ligands tune the parathyroid hormone receptor’s grip on β-arrestin	30
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1	30
Mapping the conformational landscape of the stimulatory heterotrimeric G protein	30
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function	30
Structural insights into the regulation of Cas7-11 by TPR-CHAT	30
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity	30
Regulation of kinesin-2 motility by its β-hairpin motif	30
Towards a structurally resolved human protein interaction network	30
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families	29
Structural insights into TRPV2 modulation by probenecid	29
An egg-ceptional mechanism of acentrosomal spindle assembly	29
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA	29
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation	29
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor	29
How one molecule senses light and temperature	29
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex	29
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	29
Neuronal VPS13D loss drives microglial activation	28
Exposing chromothripsis	28
Structural basis for CaVα2δ:gabapentin binding	28
Structural basis for retron co-option of anti-phage ATPase-nuclease	28
Space exploration: finding new protein conformations using AlphaFold2	28
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	28
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	28
Structural insights into SV2A and the mechanism of racetam anticonvulsants	28
Structure of the γ-tubulin ring complex-capped microtubule	28
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	28
Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel	27
A conformational switch controlling the toxicity of the prion protein	27
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	27
Computational design of sequence-specific DNA-binding proteins	27
From atoms to cells	27
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	27
The molecular basis of lamin-specific chromatin interactions	27
A unifying model for membrane protein biogenesis	27
Building up complexity in structural biology studies	26
Ebola virus L–VP35 structure	26
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	26
Caught in the act: how a brake on cell growth is anchored to lysosomes	26
Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels	26
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	26
A snapshot of proteostasis in human oocytes	26
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation	26
Human primase hangs on the primer–template and Polα to facilitate primer termination	26
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals	26
Closing 2025, and a look ahead	26
Natural selection finds a way, even under heavy constraints	26
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	26
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	26
Cracking the case of m7G modification in human tRNAs	25
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis	25
No stasis in proteostasis	25
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation	25
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling	25
Architecture of the ESCPE-1 membrane coat	25
Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis	25
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor	24
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas	24
Membrane-embedded machines	24
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis	24
AlphaFold3 takes a step toward decoding molecular behavior and biological computation	24
The impact of DNA methylation on CTCF-mediated 3D genome organization	24
An in vivo platform to screen for regulators of Huntington’s disease	24
Future opportunities in solute carrier structural biology	24
Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome	24
The RNA world	24
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase	24
Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1	23
A cohesin traffic pattern genetically linked to gene regulation	23
GABA transport cycle: beyond a GAT feeling	23
The rise of ADP-ribose–ubiquitin	23
Quantitative analysis of transcription start site selection reveals control by DNA sequence, RNA polymerase II activity and NTP levels	23
The essential functions of protein SUMOylation in cell proliferation	23
A negative feedback mechanism controls histone gene expression	23
Structures of the ribosome bound to EF-Tu–isoleucine tRNA elucidate the mechanism of AUG avoidance	23
Structural basis of sequence-specific cytosine deamination by double-stranded DNA deaminase toxin DddA	23
Mitotic bookmarking redundancy by nuclear receptors in pluripotent cells	23
Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice	23