Nature Structural & Molecular Biology

Article	Citations
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects	458
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis	441
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation	421
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2	411
Controlling the SARS-CoV-2 spike glycoprotein conformation	360
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur	324
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers	278
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient	256
A thermostable, closed SARS-CoV-2 spike protein trimer	253
A structural biology community assessment of AlphaFold2 applications	246
Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion	246
Enhancer RNAs are an important regulatory layer of the epigenome	207
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A	194
AlphaFold2 and the future of structural biology	192
Can AlphaFold2 predict the impact of missense mutations on structure?	169
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs	168
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation	167
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation	148
Structural basis for broad coronavirus neutralization	143
Cryo-EM structure of the entire mammalian F-type ATP synthase	122
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function	119
Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils	115
The molecular structure of mammalian primary cilia revealed by cryo-electron tomography	114
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies	113
Molnupiravir: coding for catastrophe	112

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery	107
Cryo-EM structure of an amyloid fibril formed by full-length human prion protein	105
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent	104
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin	103
Decoding mRNA translatability and stability from the 5′ UTR	102
GPCR activation mechanisms across classes and macro/microscales	101
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation	97
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils	95
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS	94
Heat-dependent opening of TRPV1 in the presence of capsaicin	93
It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation	92
Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation	89
Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism	88
Dnmt1 has de novo activity targeted to transposable elements	85
Structures of radial spokes and associated complexes important for ciliary motility	83
Molecular mechanism for rotational switching of the bacterial flagellar motor	81
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes	78
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome	77
Single-gene imaging links genome topology, promoter–enhancer communication and transcription control	77
Membrane constriction and thinning by sequential ESCRT-III polymerization	75
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads	75
Towards a structurally resolved human protein interaction network	74
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel	74
Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core	72
Structural basis of nucleosome transcription mediated by Chd1 and FACT	72
Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs	72
Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly	70
Structural insights into the regulation of human serine palmitoyltransferase complexes	65
Cold sensitivity of the SARS-CoV-2 spike ectodomain	64
Dimers of DNA-PK create a stage for DNA double-strand break repair	64
Reconstitution of translesion synthesis reveals a mechanism of eukaryotic DNA replication restart	61
Endogenous retroviruses drive species-specific germline transcriptomes in mammals	59
RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome	59
PARP inhibition impedes the maturation of nascent DNA strands during DNA replication	58
Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression	58
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency	58
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity	57
Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex	57
Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR	57
The oligomeric structures of plant cryptochromes	57
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states	57
Multi-contact 3C reveals that the human genome during interphase is largely not entangled	56
The case for post-predictional modifications in the AlphaFold Protein Structure Database	55
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1	54
The condensin holocomplex cycles dynamically between open and collapsed states	54
Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex	54
Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles	54
Mechanistic insight into substrate processing and allosteric inhibition of human p97	54
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism	54
Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB	53

Conformational buffering underlies functional selection in intrinsically disordered protein regions	53
Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis	52
The structural basis of fatty acid elongation by the ELOVL elongases	52
The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism	51
DNA interference states of the hypercompact CRISPR–CasΦ effector	51
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution	51
Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily	50
Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development	49
Structural basis of RNA processing by human mitochondrial RNase P	49
Large-scale tethered function assays identify factors that regulate mRNA stability and translation	49
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes	48
Regulation of translation by site-specific ribosomal RNA methylation	48
Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis	48
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores	48
BAK core dimers bind lipids and can be bridged by them	47
The coupling mechanism of mammalian mitochondrial complex I	47
DNA-loop-extruding SMC complexes can traverse one another in vivo	47
Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription	47
Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state	47
Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks	45
The three-dimensional structure of human β-endorphin amyloid fibrils	45
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome	45
Cryo-EM structures of Toll-like receptors in complex with UNC93B1	45
Gating of human TRPV3 in a lipid bilayer	44
A structural model of a Ras–Raf signalosome	44
Target-induced clustering activates Trim-Away of pathogens and proteins	44
Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62	43
Structural basis of CD4 downregulation by HIV-1 Nef	43
Reprogramming of the histone H3.3 landscape in the early mouse embryo	43
TET2 chemically modifies tRNAs and regulates tRNA fragment levels	42
Retinoic acid signaling is critical during the totipotency window in early mammalian development	42
Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis	42
Viral hijacking of the TENT4–ZCCHC14 complex protects viral RNAs via mixed tailing	42
Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2	42
Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A	42
Structural basis for STAT2 suppression by flavivirus NS5	41
Structure determination of inactive-state GPCRs with a universal nanobody	41
The structure of a virus-encoded nucleosome	41
Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry	41
Structural and functional characterization of the Spo11 core complex	41
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	40
Mechanism of ligand activation of a eukaryotic cyclic nucleotide−gated channel	40
Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment	40
A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission	40
Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity	39
Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating	38
SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations	38
Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes	38
Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition	38
Ciliary central apparatus structure reveals mechanisms of microtubule patterning	38
Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease	38
Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol	37
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9	37
Molecular basis for kinin selectivity and activation of the human bradykinin receptors	37
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation	37
Quantification of translation uncovers the functions of the alternative transcriptome	36
CRISPR–Cas9 bends and twists DNA to read its sequence	36
Synergistic activation of the insulin receptor via two distinct sites	36
A structurally minimized yet fully active insulin based on cone-snail venom insulin principles	36
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans	35
Cryo-EM structure of the Hippo signaling integrator human STRIPAK	35
Structural insights into transcriptional regulation of human RNA polymerase III	35
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	35
Kinetic principles underlying pioneer function of GAGA transcription factor in live cells	34
Structural basis for bacterial lipoprotein relocation by the transporter LolCDE	34
Architecture of the human erythrocyte ankyrin-1 complex	34
Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins	34
Structural mechanism of muscle nicotinic receptor desensitization and block by curare	34
Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation	33
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	33
Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate	33
Structures of mouse DUOX1–DUOXA1 provide mechanistic insights into enzyme activation and regulation	33
Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory	32
Cryo-EM structure of the human MT1–Gi signaling complex	32
Seipin forms a flexible cage at lipid droplet formation sites	32
CENP-N promotes the compaction of centromeric chromatin	31
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics	31
Cryo-EM structure of an active central apparatus	31
Chemical RNA digestion enables robust RNA-binding site mapping at single amino acid resolution	31
mRNA structural dynamics shape Argonaute-target interactions	31

H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage	30
Snapshots of actin and tubulin folding inside the TRiC chaperonin	30
Quantifying the dynamics of IRES and cap translation with single-molecule resolution in live cells	30
A first exon termination checkpoint preferentially suppresses extragenic transcription	30
Could AlphaFold revolutionize chemical therapeutics?	30
The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma	30
Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers	29
CDK11 is required for transcription of replication-dependent histone genes	29
Cohesin is required for long-range enhancer action at the Shh locus	29
Structure of the human SAGA coactivator complex	29
Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops	29
IMPDH1 retinal variants control filament architecture to tune allosteric regulation	29
ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy	29
The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains	28
Alternative polyadenylation by sequential activation of distal and proximal PolyA sites	28
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres	28
Molecular organization of the E. coli cellulose synthase macrocomplex	28
Safeguarding mitochondrial genomes in higher eukaryotes	28
The oxytocin signaling complex reveals a molecular switch for cation dependence	28
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition	27
Structure of the FA core ubiquitin ligase closing the ID clamp on DNA	27
A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation	27
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	27
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	27
Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis	27
Cryo-EM structures of human RNA polymerase I	27
Regulation of ALT-associated homology-directed repair by polyADP-ribosylation	27
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism	26
Imbalances in the eye lens proteome are linked to cataract formation	26
Structural basis for DNA targeting by the Tn7 transposon	26
Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2	26
Molecular basis of human ATM kinase inhibition	26
Structural basis and mechanism of activation of two different families of G proteins by the same GPCR	25
Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming	25
A cohesin traffic pattern genetically linked to gene regulation	25
Single-stranded nucleic acid binding and coacervation by linker histone H1	25
Structural insights into assembly and function of the RSC chromatin remodeling complex	25
Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis	24
Structural and functional characterization of the bestrophin-2 anion channel	24
The tertiary structure of the human Xkr8–Basigin complex that scrambles phospholipids at plasma membranes	24
Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation	24
Plasticity in ligand recognition at somatostatin receptors	24
Scaffolding protein CcmM directs multiprotein phase separation in β-carboxysome biogenesis	24
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization	24
A pioneer factor locally opens compacted chromatin to enable targeted ATP-dependent nucleosome remodeling	23
Current challenges in understanding the role of enhancers in disease	23
Structural insights into telomere protection and homeostasis regulation by yeast CST complex	23
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	23
Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis	23
Condensin-driven loop extrusion on supercoiled DNA	23
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins	22
Structural insights into binding of therapeutic channel blockers in NMDA receptors	22
Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery	22
Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12	22
Mechanisms of loading and release of the 9-1-1 checkpoint clamp	22
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase	22
Scaling analysis reveals the mechanism and rates of prion replication in vivo	22
Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids	21
An atypical RNA quadruplex marks RNAs as vectors for gene silencing	21
Structural basis of FANCD2 deubiquitination by USP1−UAF1	21
In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes	21
The structural basis of PTEN regulation by multi-site phosphorylation	21
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1	21
The selection process of licensing a DNA mismatch for repair	21
Structural insights into Fe–S protein biogenesis by the CIA targeting complex	21