Nature Structural & Molecular Biology

Article	Citations
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	635
Surviving under stress conditions	256
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	151
30 years of structural and molecular biology and counting	128
Structure of the HCV glycoprotein	125
Author Correction: Polλ promotes microhomology-mediated end-joining	122
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	115
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site	109
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	104
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism	101
Author Correction: Structure and mechanism of antiphage retron Eco2	99
Charting the 3D regulatory landscape of sex determination with geostatistics	98
Structural basis of branching during RNA splicing	97
Constitutive activation mechanism of a class C GPCR	84
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	84
Accessible technology for diploid high-order 3D human genome analysis	83
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	81
Endocrine resistance and breast cancer plasticity are controlled by CoREST	78
Protein import into mitochondria — a new path through the membranes	77
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	76
Gene regulation through exon junction complex modularity	74
Shifting our perspective on orphan G protein-coupled receptors	73
Yolk transports miRNAs to embryos and enhances progeny stress resilience	73
Towards a molecular and structural definition of cell death	73
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	72

P-type ATPase magnesium transporter MgtA acts as a dimer	72
A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients	70
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	70
Structural insights into translocation and tailored synthesis of hyaluronan	70
Current challenges in understanding the role of enhancers in disease	68
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	68
Exploration of novel αβ-protein folds through de novo design	68
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	66
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	66
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	66
The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	65
Transcription directionality is licensed by Integrator at active human promoters	65
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization	64
Structures of aberrant spliceosome intermediates on their way to disassembly	64
Studying the impact of the nuclear topography on gene function	63
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	63
A personal perspective of the voltage-gated potassium channel studies	61
Cohesin closes the door on coexpression	61
Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development	60
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	60
EGOC inhibits TOROID polymerization by structurally activating TORC1	57
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM	57
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	57
Checking in on proteostasis	57
Better SIFI than sorry	57
Author Correction: Cryo-EM structure of an active central apparatus	57
Author Correction: Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	56
MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy	55
Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport	55
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	55
Smc5/6 silences episomal transcription by a three-step function	54
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells	54
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	53
Understanding ubiquitination in neurodevelopment by integrating insights across space and time	52
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	52
SCAF1 drives the compositional diversity of mammalian respirasomes	51
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex	51
Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex	51
The conformational landscape of human transthyretin revealed by cryo-EM	50
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes	50
Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo	50
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	50
Control of transcription elongation and DNA repair by alarmone ppGpp	49
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation	49
Function and regulation of the mitochondrial stress response	49
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers	49
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution	48
THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development	48
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics	47
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates	47

Structures of transcription preinitiation complex engaged with the +1 nucleosome	46
Virtual screen raises hit rate	46
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos	46
Thirty years of structural changes	46
Direct coupling of human TOM and TIM22 complexes drives mitochondrial carrier import	46
Perfect match: PET ligand fits snugly into folded Tau filaments	46
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation	45
Transcription and replication meet the silent X chromosome territory	45
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)	45
Transcription modulates chromatin dynamics and locus configuration sampling	45
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization	45
Dynamics of microcompartment formation at the mitosis-to-G1 transition	45
Structural basis of hepatitis B virus receptor binding	44
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation	43
Functional epigenomics: chromatin complexity untangled	43
STING to the lysosome’s rescue	43
Finding and recycling stalled spliceosomes	43
Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1	43
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure	43
All roads lead to MRN regulation at telomeres: different paths to one solution	42
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening	42
Structure and function of the human mitochondrial MRS2 channel	42
Transport mechanism of presynaptic high-affinity choline uptake by CHT1	41
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants	41
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly	41
Structural basis for the dynamic chaperoning of disordered clients by Hsp90	40
ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network	40
Structure and interactions of the endogenous human Commander complex	40
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies	40
Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs	39
Structural basis of circularly permuted group II intron self-splicing	39
Two dynamically competing factors determine the translation start site	39
Structural clues about bridge-mediated lipid transfer	39
Structure of a volume-regulated heteromeric LRRC8A/C channel	38
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus	38
Structural insights into the iron nitrogenase complex	38
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC	38
Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed	38
Conformational plasticity of human acid-sensing ion channel 1a	38
Regulatory activity is the default DNA state in eukaryotes	38
MitoPerturb-Seq identifies links between nuclear and mitochondrial genomes in single cells	38
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine	38
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	38
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37	38
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling	38
Hallucination of closed repeat proteins containing central pockets	37
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis	37
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans	37
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development	37
Structure of RAS signaling regulator complex reveals mechanism	37
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	37
A chromatin mesh model for compaction of chromatin by PRC1 in condensates	36
Looking back at 30 years of Nature Structural & Molecular Biology	36
Structure and function of a broad-range thermal receptor in myriapods	36
Mechanism and reconstitution of circadian transcription in cyanobacteria	36
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1	36
Mechanical disengagement of the cohesin ring	36
Ferlin structures	36
PARP1 and HPF1 team up to flag down DNA-repair machinery	36
Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity	36
EMProt improves structure determination from cryo-EM maps	35
De novo design of obligate ABC-type heterotrimeric proteins	35
Mechanisms for licensing origins of DNA replication in eukaryotic cells	35
The structure of the NuA4–Tip60 complex reveals the mechanism and importance of long-range chromatin modification	35
The yeast genome is globally accessible in living cells	35
Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides	35
A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling	35
Remote on–off switching of protein activity by intrinsically disordered region	34
Molecular basis of the TRAP complex function in ER protein biogenesis	34
Distinct tau filament folds in human MAPT mutants P301L and P301T	34
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis	34
Putting numbers on chromatin looping	34
Structural basis of pH-dependent activation in a CLC transporter	34
A nanobody-based therapeutic targeting Nipah virus limits viral escape	34
Actin up: shifting chromosomes toward repair, but also translocations	33
Menopause age and cancer risk is influenced by rare genetic variants	33
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis	33
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase	33
Replication licensing during S phase: breaking the law to prevent breaking DNA	33
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence	33

Extending guide RNA length restores high-fidelity CRISPR–Cas9 activity	33
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss	33
Returning home to navigate challenges and meet potential in Poland	33
Author Correction: Smc5/6 silences episomal transcription by a three-step function	33
Cryo-EM structures of the Spo11 core complex bound to DNA	32
How ligands tune the parathyroid hormone receptor’s grip on β-arrestin	32
Structural insights into the regulation of Cas7-11 by TPR-CHAT	32
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1	32
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia	32
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells	32
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication	32
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets	32
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA	31
Mechanism of mammalian transcriptional repression by noncoding RNA	31
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation	31
Kinetic control of mammalian transcription elongation	31
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity	31
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families	31
TMEM170 proteins are lipid scramblases associated with bridge-type lipid transporters BLTP1/Csf1	31
Regulation of kinesin-2 motility by its β-hairpin motif	31
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex	31
Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types	31
Structural insights into TRPV2 modulation by probenecid	31
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing	30
How one molecule senses light and temperature	30
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function	30
Mapping the conformational landscape of the stimulatory heterotrimeric G protein	30
Towards a structurally resolved human protein interaction network	30
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W	30
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor	30
An egg-ceptional mechanism of acentrosomal spindle assembly	29
Neuronal VPS13D loss drives microglial activation	29
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	29
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	29
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	29
Structural basis for CaVα2δ:gabapentin binding	29
Structural insights into SV2A and the mechanism of racetam anticonvulsants	29
Space exploration: finding new protein conformations using AlphaFold2	29
Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel	29
Structure of the γ-tubulin ring complex-capped microtubule	29
A unifying model for membrane protein biogenesis	28
Bridge for lipid delivery	28
Computational design of sequence-specific DNA-binding proteins	28
A conformational switch controlling the toxicity of the prion protein	28
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	28
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	28
The molecular basis of lamin-specific chromatin interactions	28
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	28
A protective ESCRT sleeve for ultrafine DNA bridges	27
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	27
From atoms to cells	27
Caught in the act: how a brake on cell growth is anchored to lysosomes	27
Structural basis for retron co-option of anti-phage ATPase-nuclease	27
Ebola virus L–VP35 structure	27
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	27
A snapshot of proteostasis in human oocytes	27
Human primase hangs on the primer–template and Polα to facilitate primer termination	27
Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels	27
Closing 2025, and a look ahead	27
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals	27
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation	26
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase	26
Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis	26
Future opportunities in solute carrier structural biology	26
No stasis in proteostasis	26
Natural selection finds a way, even under heavy constraints	26
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas	26
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	26
The impact of DNA methylation on CTCF-mediated 3D genome organization	26
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor	26
Cracking the case of m7G modification in human tRNAs	26
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis	26
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling	26
AlphaFold3 takes a step toward decoding molecular behavior and biological computation	25
PLA2G2F suppresses ferroptosis through phospholipid remodeling	25
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	25
Architecture of the ESCPE-1 membrane coat	25
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation	25
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis	25
Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome	25
Building up complexity in structural biology studies	25
Membrane-embedded machines	25
The RNA world	25
An in vivo platform to screen for regulators of Huntington’s disease	24
The essential functions of protein SUMOylation in cell proliferation	24
GABA transport cycle: beyond a GAT feeling	24
Looking back at 2023	24
Quantitative analysis of transcription start site selection reveals control by DNA sequence, RNA polymerase II activity and NTP levels	24
A negative feedback mechanism controls histone gene expression	24
Structural basis for membrane remodeling by the AP5–SPG11–SPG15 complex	24
A cohesin traffic pattern genetically linked to gene regulation	24
Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice	24
Filament formation and NAD processing by noncanonical human FAM118 sirtuins	23
A horizontal gene-transfer-like mechanism in mammalian cells	23
Structures of the ribosome bound to EF-Tu–isoleucine tRNA elucidate the mechanism of AUG avoidance	23