Nature Structural & Molecular Biology

Article	Citations
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects	473
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis	471
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation	447
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2	423
Controlling the SARS-CoV-2 spike glycoprotein conformation	372
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers	289
A structural biology community assessment of AlphaFold2 applications	279
Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion	270
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient	262
A thermostable, closed SARS-CoV-2 spike protein trimer	258
AlphaFold2 and the future of structural biology	216
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A	203
Can AlphaFold2 predict the impact of missense mutations on structure?	194
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation	180
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs	175
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation	155
Structural basis for broad coronavirus neutralization	152
Cryo-EM structure of the entire mammalian F-type ATP synthase	128
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function	122
The molecular structure of mammalian primary cilia revealed by cryo-electron tomography	122
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies	120
Molnupiravir: coding for catastrophe	116
GPCR activation mechanisms across classes and macro/microscales	116
Decoding mRNA translatability and stability from the 5′ UTR	116
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS	107

A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent	107
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin	106
Heat-dependent opening of TRPV1 in the presence of capsaicin	106
It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation	105
Towards a structurally resolved human protein interaction network	103
Structures of radial spokes and associated complexes important for ciliary motility	98
Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism	97
Dnmt1 has de novo activity targeted to transposable elements	94
Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation	93
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes	91
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome	86
Molecular mechanism for rotational switching of the bacterial flagellar motor	85
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads	82
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel	81
Single-gene imaging links genome topology, promoter–enhancer communication and transcription control	81
Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs	80
Structural basis of nucleosome transcription mediated by Chd1 and FACT	79
PARP inhibition impedes the maturation of nascent DNA strands during DNA replication	75
Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly	73
Structural insights into the regulation of human serine palmitoyltransferase complexes	71
Dimers of DNA-PK create a stage for DNA double-strand break repair	68
Endogenous retroviruses drive species-specific germline transcriptomes in mammals	65
Multi-contact 3C reveals that the human genome during interphase is largely not entangled	65
Cold sensitivity of the SARS-CoV-2 spike ectodomain	64
Large-scale tethered function assays identify factors that regulate mRNA stability and translation	64
Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression	63
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency	61
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism	61
Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex	61
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity	60
The condensin holocomplex cycles dynamically between open and collapsed states	60
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes	59
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1	59
Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR	59
The structural basis of fatty acid elongation by the ELOVL elongases	59
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states	58
Mechanistic insight into substrate processing and allosteric inhibition of human p97	58
The case for post-predictional modifications in the AlphaFold Protein Structure Database	58
Structural basis of RNA processing by human mitochondrial RNase P	57
Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB	57
Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis	55
Conformational buffering underlies functional selection in intrinsically disordered protein regions	55
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores	55
The coupling mechanism of mammalian mitochondrial complex I	55
Regulation of translation by site-specific ribosomal RNA methylation	55
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution	55
DNA interference states of the hypercompact CRISPR–CasΦ effector	54
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome	53
Cryo-EM structures of Toll-like receptors in complex with UNC93B1	53
DNA-loop-extruding SMC complexes can traverse one another in vivo	53

Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily	52
Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription	50
BAK core dimers bind lipids and can be bridged by them	50
TET2 chemically modifies tRNAs and regulates tRNA fragment levels	50
Structure determination of inactive-state GPCRs with a universal nanobody	49
Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62	48
The three-dimensional structure of human β-endorphin amyloid fibrils	48
Structural and functional characterization of the Spo11 core complex	47
Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state	47
Reprogramming of the histone H3.3 landscape in the early mouse embryo	47
Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis	46
Structural basis for STAT2 suppression by flavivirus NS5	46
The structure of a virus-encoded nucleosome	46
Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition	46
Target-induced clustering activates Trim-Away of pathogens and proteins	46
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	45
A structural model of a Ras–Raf signalosome	45
Structural basis of CD4 downregulation by HIV-1 Nef	45
Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating	45
Retinoic acid signaling is critical during the totipotency window in early mammalian development	45
Structural mechanism of muscle nicotinic receptor desensitization and block by curare	44
Ciliary central apparatus structure reveals mechanisms of microtubule patterning	43
Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A	43
Structures of mouse DUOX1–DUOXA1 provide mechanistic insights into enzyme activation and regulation	43
Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry	42
Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory	41
CRISPR–Cas9 bends and twists DNA to read its sequence	41
Cryo-EM structure of the human MT1–Gi signaling complex	41
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans	41
Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease	41
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	41
Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol	40
Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins	40
Synergistic activation of the insulin receptor via two distinct sites	40
Molecular basis for kinin selectivity and activation of the human bradykinin receptors	40
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation	40
Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes	39
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	39
Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers	39
Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity	39
Kinetic principles underlying pioneer function of GAGA transcription factor in live cells	39
Architecture of the human erythrocyte ankyrin-1 complex	39
Cryo-EM structure of an active central apparatus	38
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9	38
Structural basis for bacterial lipoprotein relocation by the transporter LolCDE	37
Seipin forms a flexible cage at lipid droplet formation sites	37
Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation	37
The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma	37
The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains	37
CENP-N promotes the compaction of centromeric chromatin	36
Single-stranded nucleic acid binding and coacervation by linker histone H1	36
Cryo-EM structure of the Hippo signaling integrator human STRIPAK	36
Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops	36
A first exon termination checkpoint preferentially suppresses extragenic transcription	36
Cohesin is required for long-range enhancer action at the Shh locus	36
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres	35
Structural insights into transcriptional regulation of human RNA polymerase III	35
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	35
Alternative polyadenylation by sequential activation of distal and proximal PolyA sites	33
Molecular organization of the E. coli cellulose synthase macrocomplex	33
Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2	32
Quantifying the dynamics of IRES and cap translation with single-molecule resolution in live cells	32
mRNA structural dynamics shape Argonaute-target interactions	32
Safeguarding mitochondrial genomes in higher eukaryotes	32
A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation	32
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition	32
H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage	32
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics	32
Could AlphaFold revolutionize chemical therapeutics?	32
ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy	32
Structure of the human SAGA coactivator complex	31
A cohesin traffic pattern genetically linked to gene regulation	31
Snapshots of actin and tubulin folding inside the TRiC chaperonin	31
The oxytocin signaling complex reveals a molecular switch for cation dependence	31
IMPDH1 retinal variants control filament architecture to tune allosteric regulation	30
A pioneer factor locally opens compacted chromatin to enable targeted ATP-dependent nucleosome remodeling	30
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	30
Cryo-EM structures of human RNA polymerase I	30
Condensin-driven loop extrusion on supercoiled DNA	30
Structural basis for DNA targeting by the Tn7 transposon	30

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation	30
Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis	29
Molecular basis of human ATM kinase inhibition	29
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization	29
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism	29
Scaffolding protein CcmM directs multiprotein phase separation in β-carboxysome biogenesis	29
Current challenges in understanding the role of enhancers in disease	29
Structural basis and mechanism of activation of two different families of G proteins by the same GPCR	29
Structure of the FA core ubiquitin ligase closing the ID clamp on DNA	28
In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes	28
Imbalances in the eye lens proteome are linked to cataract formation	28
Structural insights into telomere protection and homeostasis regulation by yeast CST complex	27
Plasticity in ligand recognition at somatostatin receptors	27
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins	27
Structural insights into binding of therapeutic channel blockers in NMDA receptors	27
The tertiary structure of the human Xkr8–Basigin complex that scrambles phospholipids at plasma membranes	27
Structural insights into Fe–S protein biogenesis by the CIA targeting complex	27
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	26
Deciphering the mechanical code of the genome and epigenome	26
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase	25
Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis	25
Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids	25
HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage	25
Structural insights into assembly and function of the RSC chromatin remodeling complex	25
Mechanisms of loading and release of the 9-1-1 checkpoint clamp	25
Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation	25
Regulation of human trophoblast gene expression by endogenous retroviruses	24
A critical period of translational control during brain development at codon resolution	24
The selection process of licensing a DNA mismatch for repair	24
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	24
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1	24
An atypical RNA quadruplex marks RNAs as vectors for gene silencing	24
Structural basis of FANCD2 deubiquitination by USP1−UAF1	24
Scaling analysis reveals the mechanism and rates of prion replication in vivo	24
Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules	23
Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane	23
The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities	23
Structures of transcription preinitiation complex engaged with the +1 nucleosome	23
Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery	23
Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12	23
Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential	22
Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome	22
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119	22
The structural basis of PTEN regulation by multi-site phosphorylation	22
Structure of the human cone photoreceptor cyclic nucleotide-gated channel	22
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state	22
A molecular switch modulates assembly and host factor binding of the HIV-1 capsid	21
Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2	21
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect	21
Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels	20
Three-dimensional genome organization via triplex-forming RNAs	20
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity	20
Structural biology in the fight against COVID-19	20
Structure of a volume-regulated heteromeric LRRC8A/C channel	20
Kicking off sphingolipid biosynthesis: structures of the serine palmitoyltransferase complex	20
Structural insight into apelin receptor-G protein stoichiometry	20
DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp	20
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair	20
The Mediator complex regulates enhancer-promoter interactions	19
Mining for METTL3 inhibitors to suppress cancer	19
Gene regulation on extrachromosomal DNA	19
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly	19
Smc5/6 silences episomal transcription by a three-step function	19
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress	19
Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation	19
Making the invisible enemy visible	19
Inactive and active state structures template selective tools for the human 5-HT5A receptor	19
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation	19