Nature Structural & Molecular Biology

Article	Citations
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	459
Structural insights into metazoan pretargeting GET complexes	281
Author Correction: Polλ promotes microhomology-mediated end-joining	224
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	199
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism	132
P-type ATPase magnesium transporter MgtA acts as a dimer	130
30 years of structural and molecular biology and counting	128
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	126
A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients	123
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	103
Structural insights into translocation and tailored synthesis of hyaluronan	95
Structure of the HCV glycoprotein	89
Structures of aberrant spliceosome intermediates on their way to disassembly	88
Transcription directionality is licensed by Integrator at active human promoters	88
Accessible technology for diploid high-order 3D human genome analysis	87
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site	87
Structural basis of branching during RNA splicing	82
Surviving under stress conditions	81
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization	79
Endocrine resistance and breast cancer plasticity are controlled by CoREST	78
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	78
Exploration of novel αβ-protein folds through de novo design	77
Snapshots of actin and tubulin folding inside the TRiC chaperonin	75
Shifting our perspective on orphan G protein-coupled receptors	75
Protein import into mitochondria — a new path through the membranes	75

The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	74
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation	73
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	72
Constitutive activation mechanism of a class C GPCR	70
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	69
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	67
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	66
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	64
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	62
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	62
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	60
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	60
Current challenges in understanding the role of enhancers in disease	60
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	59
Studying the impact of the nuclear topography on gene function	58
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	58
Binding NEMO: Liquid–liquid phase separation captures immune regulator	58
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos	57
THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development	56
The conformational landscape of human transthyretin revealed by cryo-EM	56
Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport	55
Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo	54
Control of transcription elongation and DNA repair by alarmone ppGpp	54
Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair	53
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	53
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	52
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells	52
Building insights into KRAS signaling complexes	51
Author Correction: Cryo-EM structure of an active central apparatus	51
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM	51
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex	51
A personal perspective of the voltage-gated potassium channel studies	50
Better SIFI than sorry	50
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	50
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	50
Cohesin closes the door on coexpression	50
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics	48
SCAF1 drives the compositional diversity of mammalian respirasomes	48
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution	48
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates	48
Structures of transcription preinitiation complex engaged with the +1 nucleosome	48
Phase separation drives X-chromosome inactivation	47
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes	47
EGOC inhibits TOROID polymerization by structurally activating TORC1	47
Smc5/6 silences episomal transcription by a three-step function	47
Author Correction: Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	47
Understanding ubiquitination in neurodevelopment by integrating insights across space and time	47
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers	47
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	46
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	46

DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation	46
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	46
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism	45
Cryo-EM structure of an active central apparatus	45
Transcription modulates chromatin dynamics and locus configuration sampling	44
The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes	44
Perfect match: PET ligand fits snugly into folded Tau filaments	44
Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1	44
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure	43
Functional epigenomics: chromatin complexity untangled	43
All roads lead to MRN regulation at telomeres: different paths to one solution	42
Diverse activation mechanisms of PI3Ks	41
Transcription and replication meet the silent X chromosome territory	41
Thirty years of structural changes	41
Virtual screen raises hit rate	41
Evolution of a histone variant involved in compartmental regulation of NAD metabolism	40
STING to the lysosome’s rescue	40
TALEDs complete the toolkit for editing human mitochondrial DNA	40
Transport mechanism of presynaptic high-affinity choline uptake by CHT1	40
Finding and recycling stalled spliceosomes	40
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies	40
CENP-N promotes the compaction of centromeric chromatin	39
Structure and interactions of the endogenous human Commander complex	39
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization	39
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening	39
Structural basis of circularly permuted group II intron self-splicing	39
Structure and function of the human mitochondrial MRS2 channel	38
The coupling mechanism of mammalian mitochondrial complex I	38
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly	38
Structural basis for the dynamic chaperoning of disordered clients by Hsp90	38
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)	38
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation	38
ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network	37
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads	37
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants	37
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation	37
Looking back at 2021	36
MacroH2A1.1 has evolved to let PARP1 do more by loosening its grip on PAR	36
DNA replication at high res	36
Structural basis of hepatitis B virus receptor binding	36
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus	35
Cryptic elements of the heat-shock response	35
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37	35
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase	34
Regulatory activity is the default DNA state in eukaryotes	34
Hallucination of closed repeat proteins containing central pockets	34
Structural clues about bridge-mediated lipid transfer	34
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC	34
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine	33
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans	33
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis	33
Structure of a volume-regulated heteromeric LRRC8A/C channel	32
Structural insights into the iron nitrogenase complex	32
Molting mitochondria	32
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development	32
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling	32
Cryo-EM structures of human RNA polymerase I	32
Molecular basis of human ATM kinase inhibition	32
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	32
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	32
De novo design of tyrosine and serine kinase-driven protein switches	32
A chromatin mesh model for compaction of chromatin by PRC1 in condensates	31
Looking back at 30 years of Nature Structural & Molecular Biology	31
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	31
Structure of RAS signaling regulator complex reveals mechanism	31
A tweak and a peek: How Cas9 pries open double-stranded DNA to check its sequence	31
The yeast genome is globally accessible in living cells	30
PARP1 and HPF1 team up to flag down DNA-repair machinery	30
Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides	30
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1	30
Mechanical disengagement of the cohesin ring	30
A nanobody-based therapeutic targeting Nipah virus limits viral escape	30
Ferlin structures	29
Structure and function of a broad-range thermal receptor in myriapods	29
Structural basis of pH-dependent activation in a CLC transporter	29
Parkinson’s disease risk protein TMEM175 keeps lysosomes running on a proton leak	29
The structure of the NuA4–Tip60 complex reveals the mechanism and importance of long-range chromatin modification	29
Remote on–off switching of protein activity by intrinsically disordered region	29
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence	28
Molecular basis of the TRAP complex function in ER protein biogenesis	28

Mechanisms for licensing origins of DNA replication in eukaryotic cells	28
De novo design of obligate ABC-type heterotrimeric proteins	28
Distinct tau filament folds in human MAPT mutants P301L and P301T	28
Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta	28
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase	28
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis	28
Actin up: shifting chromosomes toward repair, but also translocations	27
Author Correction: Smc5/6 silences episomal transcription by a three-step function	27
Mapping the conformational landscape of the stimulatory heterotrimeric G protein	27
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication	27
Replication licensing during S phase: breaking the law to prevent breaking DNA	27
Menopause age and cancer risk is influenced by rare genetic variants	27
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA	27
Cryo-EM structures of the Spo11 core complex bound to DNA	27
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss	27
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis	27
Author Correction: Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation	27
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1	26
Structural insights into the regulation of Cas7-11 by TPR-CHAT	26
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor	26
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate	26
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity	26
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W	26
Regulation of kinesin-2 motility by its β-hairpin motif	26
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells	26
Returning home to navigate challenges and meet potential in Poland	26
Mechanism of mammalian transcriptional repression by noncoding RNA	26
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing	26
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation	25
Building a molecular rotor	25
Exposing chromothripsis	25
Structural insights into TRPV2 modulation by probenecid	25
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex	25
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets	25
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia	25
Towards a structurally resolved human protein interaction network	25
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function	25
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families	25
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins	25
How one molecule senses light and temperature	24
The molecular basis of lamin-specific chromatin interactions	24
Structure of the γ-tubulin ring complex-capped microtubule	24
A conformational switch controlling the toxicity of the prion protein	24
An egg-ceptional mechanism of acentrosomal spindle assembly	24
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	24
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	24
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	24
Space exploration: finding new protein conformations using AlphaFold2	24
Plasticity in ligand recognition at somatostatin receptors	24
Structural basis for CaVα2δ:gabapentin binding	24
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	23
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	23
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	23
PIEZOs in vacuoles	23
Neuronal VPS13D loss drives microglial activation	23
A unifying model for membrane protein biogenesis	23
Human primase hangs on the primer–template and Polα to facilitate primer termination	23
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	23
Structural insights into SV2A and the mechanism of racetam anticonvulsants	23
Ebola virus L–VP35 structure	23
From atoms to cells	23
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	23
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals	22
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair	22
Cracking the case of m7G modification in human tRNAs	22
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis	22
Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis	22
Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels	22
Building up complexity in structural biology studies	22
Decoupling of degradation from deadenylation reshapes poly(A) tail length in yeast meiosis	22
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	21
Could AlphaFold revolutionize chemical therapeutics?	21
Natural selection finds a way, even under heavy constraints	21
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation	21
Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome	21
The impact of DNA methylation on CTCF-mediated 3D genome organization	21
Future opportunities in solute carrier structural biology	21
AlphaFold3 takes a step toward decoding molecular behavior and biological computation	21
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor	21
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling	21
Architecture of the ESCPE-1 membrane coat	20
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas	20
The RNA world	20
An in vivo platform to screen for regulators of Huntington’s disease	20
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome	20
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation	20
The essential functions of protein SUMOylation in cell proliferation	20
GABA transport cycle: beyond a GAT feeling	20
ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility	20
Membrane-embedded machines	20
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis	20
Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice	20
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase	20
Looking back at 2023	20
Higher-order phosphatase–substrate contacts terminate the integrated stress response	20