Nature Structural & Molecular Biology

(The TQCC of Nature Structural & Molecular Biology is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects462
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis454
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation428
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2413
Controlling the SARS-CoV-2 spike glycoprotein conformation367
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur326
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers282
Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient258
A thermostable, closed SARS-CoV-2 spike protein trimer257
Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion257
A structural biology community assessment of AlphaFold2 applications253
Enhancer RNAs are an important regulatory layer of the epigenome216
AlphaFold2 and the future of structural biology201
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A198
Can AlphaFold2 predict the impact of missense mutations on structure?178
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation171
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs171
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation152
Structural basis for broad coronavirus neutralization147
Cryo-EM structure of the entire mammalian F-type ATP synthase124
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function120
Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils118
The molecular structure of mammalian primary cilia revealed by cryo-electron tomography116
Molnupiravir: coding for catastrophe114
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies114
Targeted protein degradation as a powerful research tool in basic biology and drug target discovery110
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent107
Cryo-EM structure of an amyloid fibril formed by full-length human prion protein107
Decoding mRNA translatability and stability from the 5′ UTR106
GPCR activation mechanisms across classes and macro/microscales105
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin104
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation103
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS100
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils99
Heat-dependent opening of TRPV1 in the presence of capsaicin99
It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation98
Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism92
Structures of radial spokes and associated complexes important for ciliary motility90
Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation89
Dnmt1 has de novo activity targeted to transposable elements87
Towards a structurally resolved human protein interaction network85
Molecular mechanism for rotational switching of the bacterial flagellar motor85
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes84
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads81
Single-gene imaging links genome topology, promoter–enhancer communication and transcription control79
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome79
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel77
Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs75
Structural basis of nucleosome transcription mediated by Chd1 and FACT74
Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly70
Structural insights into the regulation of human serine palmitoyltransferase complexes68
Dimers of DNA-PK create a stage for DNA double-strand break repair64
Cold sensitivity of the SARS-CoV-2 spike ectodomain64
PARP inhibition impedes the maturation of nascent DNA strands during DNA replication64
Endogenous retroviruses drive species-specific germline transcriptomes in mammals63
Multi-contact 3C reveals that the human genome during interphase is largely not entangled61
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism59
RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome59
The oligomeric structures of plant cryptochromes59
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency59
Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression58
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity58
Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex57
The condensin holocomplex cycles dynamically between open and collapsed states57
Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR57
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states57
The case for post-predictional modifications in the AlphaFold Protein Structure Database56
The structural basis of fatty acid elongation by the ELOVL elongases55
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD155
Large-scale tethered function assays identify factors that regulate mRNA stability and translation54
Mechanistic insight into substrate processing and allosteric inhibition of human p9754
Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles54
DNA interference states of the hypercompact CRISPR–CasΦ effector53
Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB53
Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis53
Conformational buffering underlies functional selection in intrinsically disordered protein regions53
The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism52
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution52
Regulation of translation by site-specific ribosomal RNA methylation51
Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily51
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes51
Structural basis of RNA processing by human mitochondrial RNase P51
The coupling mechanism of mammalian mitochondrial complex I50
DNA-loop-extruding SMC complexes can traverse one another in vivo49
Cryo-EM structures of Toll-like receptors in complex with UNC93B149
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores49
Dppa2 and Dppa4 counteract de novo methylation to establish a permissive epigenome for development49
BAK core dimers bind lipids and can be bridged by them48
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome48
Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state47
Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription47
Gating of human TRPV3 in a lipid bilayer46
Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec6245
Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 245
Target-induced clustering activates Trim-Away of pathogens and proteins45
Reprogramming of the histone H3.3 landscape in the early mouse embryo45
The three-dimensional structure of human β-endorphin amyloid fibrils45
TET2 chemically modifies tRNAs and regulates tRNA fragment levels44
A structural model of a Ras–Raf signalosome44
Structural basis for STAT2 suppression by flavivirus NS544
Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis44
Structure determination of inactive-state GPCRs with a universal nanobody44
The structure of a virus-encoded nucleosome43
Viral hijacking of the TENT4–ZCCHC14 complex protects viral RNAs via mixed tailing43
Structural basis of CD4 downregulation by HIV-1 Nef43
Retinoic acid signaling is critical during the totipotency window in early mammalian development42
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state42
Structural and functional characterization of the Spo11 core complex42
Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A42
Ciliary central apparatus structure reveals mechanisms of microtubule patterning41
Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry41
Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating41
Structural mechanism of muscle nicotinic receptor desensitization and block by curare41
Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment40
A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission40
Mechanism of ligand activation of a eukaryotic cyclic nucleotide−gated channel40
Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease39
Structures of mouse DUOX1–DUOXA1 provide mechanistic insights into enzyme activation and regulation39
Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity39
Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition39
CRISPR–Cas9 bends and twists DNA to read its sequence39
Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes39
Molecular basis for kinin selectivity and activation of the human bradykinin receptors39
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation38
SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations38
Synergistic activation of the insulin receptor via two distinct sites38
Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol37
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans37
Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory37
Kinetic principles underlying pioneer function of GAGA transcription factor in live cells37
Cryo-EM structure of the human MT1–Gi signaling complex37
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A937
Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins36
Cryo-EM structure of the Hippo signaling integrator human STRIPAK36
Quantification of translation uncovers the functions of the alternative transcriptome36
A structurally minimized yet fully active insulin based on cone-snail venom insulin principles36
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening36
Architecture of the human erythrocyte ankyrin-1 complex35
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex35
Structural insights into transcriptional regulation of human RNA polymerase III35
Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation34
Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers34
Structural basis for bacterial lipoprotein relocation by the transporter LolCDE34
Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops34
Chemical RNA digestion enables robust RNA-binding site mapping at single amino acid resolution33
Cryo-EM structure of an active central apparatus33
Seipin forms a flexible cage at lipid droplet formation sites33
Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate33
mRNA structural dynamics shape Argonaute-target interactions33
ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy32
A first exon termination checkpoint preferentially suppresses extragenic transcription32
Molecular organization of the E. coli cellulose synthase macrocomplex32
Single-stranded nucleic acid binding and coacervation by linker histone H132
The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma32
Quantifying the dynamics of IRES and cap translation with single-molecule resolution in live cells32
Cohesin is required for long-range enhancer action at the Shh locus31
Could AlphaFold revolutionize chemical therapeutics?31
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes31
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics31
CENP-N promotes the compaction of centromeric chromatin31
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres30
Alternative polyadenylation by sequential activation of distal and proximal PolyA sites30
H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage30
A cohesin traffic pattern genetically linked to gene regulation30
Snapshots of actin and tubulin folding inside the TRiC chaperonin30
The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains30
Structure of the human SAGA coactivator complex30
Safeguarding mitochondrial genomes in higher eukaryotes29
Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis29
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction29
IMPDH1 retinal variants control filament architecture to tune allosteric regulation29
CDK11 is required for transcription of replication-dependent histone genes29
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism29
The oxytocin signaling complex reveals a molecular switch for cation dependence29
A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation28
Regulation of ALT-associated homology-directed repair by polyADP-ribosylation28
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition28
Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA228
Structural insights into telomere protection and homeostasis regulation by yeast CST complex27
Molecular basis of human ATM kinase inhibition27
Structure of the FA core ubiquitin ligase closing the ID clamp on DNA27
A pioneer factor locally opens compacted chromatin to enable targeted ATP-dependent nucleosome remodeling27
Cryo-EM structures of human RNA polymerase I27
Imbalances in the eye lens proteome are linked to cataract formation26
Structural basis and mechanism of activation of two different families of G proteins by the same GPCR26
The tertiary structure of the human Xkr8–Basigin complex that scrambles phospholipids at plasma membranes26
Structural basis for DNA targeting by the Tn7 transposon26
In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes26
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization26
Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis25
Plasticity in ligand recognition at somatostatin receptors25
Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation25
Current challenges in understanding the role of enhancers in disease25
Scaffolding protein CcmM directs multiprotein phase separation in β-carboxysome biogenesis25
Structural insights into assembly and function of the RSC chromatin remodeling complex25
Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming25
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins24
Structural insights into binding of therapeutic channel blockers in NMDA receptors24
Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids24
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels24
Mechanisms of loading and release of the 9-1-1 checkpoint clamp24
Structural insights into Fe–S protein biogenesis by the CIA targeting complex24
Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery23
Condensin-driven loop extrusion on supercoiled DNA23
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase23
An atypical RNA quadruplex marks RNAs as vectors for gene silencing23
Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis23
Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX1222
The selection process of licensing a DNA mismatch for repair22
Scaling analysis reveals the mechanism and rates of prion replication in vivo22
Structural basis of FANCD2 deubiquitination by USP1−UAF122
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 121
Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-221
The structural basis of PTEN regulation by multi-site phosphorylation21
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition20
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair20
A critical period of translational control during brain development at codon resolution20
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR11920
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state20
Structures of transcription preinitiation complex engaged with the +1 nucleosome20
Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential20
Deciphering the mechanical code of the genome and epigenome20
Kicking off sphingolipid biosynthesis: structures of the serine palmitoyltransferase complex20