Nature Structural & Molecular Biology

Article	Citations
Target practice: first Piwi structure with RNA	537
Aging RNA Polymerase II may speed recklessly	379
The activated inflammasome	259
Musings on art and science	240
LiBERating PARP1	194
Building a molecular rotor	172
Networking counters stress	164
Embracing change	153
Structure of the HCV glycoprotein	144
Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS	134
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	131
Structures of aberrant spliceosome intermediates on their way to disassembly	125
Single-cell joint analysis of gene expression and histone modifications in droplets	117
How one molecule senses light and temperature	115
An egg-ceptional mechanism of acentrosomal spindle assembly	110
Two rings to fold them	107
Cryo-EM for protein discovery	103
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	101
Space exploration: finding new protein conformations using AlphaFold2	100
Atomic ribosome activity	98
Multidomain interactions and ring opening of the p97 ATPase by the UBXD1 adapter	98
Exposing chromothripsis	76
Mammalian CCR4–NOT binds and ubiquitinates 80S ribosomes to enforce translational stalling	72
Tagging insulin mRNA for translation	72
Multiple allosteric mechanisms suppress PRC2 activity at active genes	71

Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	71
Illuminating cortactin structure and function at actin filament branches	70
Structure of the poxvirus core	70
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro	70
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	70
Structural basis of TRPV1 modulation by endogenous bioactive lipids	69
Computational design of non-porous pH-responsive antibody nanoparticles	68
Structure of the γ-tubulin ring complex-capped microtubule	67
Molecular basis of Gabija anti-phage supramolecular assemblies	67
ISWI catalyzes nucleosome sliding in condensed nucleosome arrays	66
Transcription directionality is licensed by Integrator at active human promoters	65
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	64
Structural insights into double-stranded RNA recognition and transport by SID-1	63
The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader	62
A unifying model for membrane protein biogenesis	62
Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel	61
VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains	60
Structural basis of the mechanism and inhibition of a human ceramide synthase	60
Molecular organization of the E. coli cellulose synthase macrocomplex	60
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	59
A first exon termination checkpoint preferentially suppresses extragenic transcription	58
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress	57
Is it a wrap? Nucleosome interactions of the BRCA1-binding partner, BARD1, steal the scene	57
Embryogenesis without CTCF in flies and vertebrates	54
Publisher Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP	54
A structural model of a Ras–Raf signalosome	54
Scaling analysis reveals the mechanism and rates of prion replication in vivo	52
Histone dynamics play a critical role in SNF2h-mediated nucleosome sliding	51
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function	51
Fatty acid elongation by ELOVL condensing enzymes depends on a histidine nucleophile	50
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution	49
Structural insights into metazoan pretargeting GET complexes	49
Chronicles of the human SAGA co-activator complex	49
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1	49
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	48
Alternative polyadenylation by sequential activation of distal and proximal PolyA sites	48
Putting the antibiotics chloramphenicol and linezolid into context	48
The partner-swapping sliding clamp loader exposed	47
Structure of human glycosylphosphatidylinositol transamidase	47
Structural mechanism of muscle nicotinic receptor desensitization and block by curare	47
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1	45
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation	45
Coupling of distant ATPase domains in the circadian clock protein KaiC	45
Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane	45
A conformational switch controlling the toxicity of the prion protein	45
Gene regulation on extrachromosomal DNA	44
Author Correction: It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation	44
Endocrine resistance and breast cancer plasticity are controlled by CoREST	44
Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome	44
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	42

Current challenges in understanding the role of enhancers in disease	42
Computational design of constitutively active cGAS	41
A critical period of translational control during brain development at codon resolution	41
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	41
Structural basis for NaV1.7 inhibition by pore blockers	41
Mechanism of cyclic β-glucan export by ABC transporter Cgt of Brucella	41
The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery	41
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition	40
Plasticity in ligand recognition at somatostatin receptors	40
Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation	39
Unwinding of a eukaryotic origin of replication visualized by cryo-EM	38
A co-transcriptional ribosome assembly checkpoint controls nascent large ribosomal subunit maturation	37
Mechanism of receptor assembly via the pleiotropic adipokine Leptin	37
Structural basis for CaVα2δ:gabapentin binding	37
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	37
Structural basis for RNA slicing by a plant Argonaute	37
Author Correction: Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization	37
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	36
Mechanisms of inward transmembrane proton translocation	36
Publisher Correction: Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site	36
DELE1 oligomerization promotes integrated stress response activation	36
Author Correction: Polλ promotes microhomology-mediated end-joining	36
Fighting pain: the structure of gabapentin and its binding site in the Cavα2δ subunit	36
Captured: the elusive eukaryotic tRNA splicing enzyme	36
Readout of histone methylation by Trim24 locally restricts chromatin opening by p53	36
Structural insights into an intracellular biased agonist for GPCRs	35
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	35
Surviving under stress conditions	35
Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability	35
Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge	34
Exploration of novel αβ-protein folds through de novo design	34
The modes of action of ion-channel-targeting neurotoxic insecticides: lessons from structural biology	34
PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense	33
Identification of the bacteriophage nucleus protein interaction network	33
POLQ to the rescue for double-strand break repair during mitosis	33
m6A governs length-dependent enrichment of mRNAs in stress granules	33
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	33
Molecular pathway of mitochondrial preprotein import through the TOM–TIM23 supercomplex	33
Structural basis of branching during RNA splicing	33
Elongation roadblocks mediated by dCas9 across human genes modulate transcription and nascent RNA processing	32
Protein import into mitochondria — a new path through the membranes	32
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	31
The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer	31
The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	31
Structure determination of inactive-state GPCRs with a universal nanobody	31
Mechanism of RecF–RecO–RecR cooperation in bacterial homologous recombination	30
Author Correction: A multipoint guidance mechanism for β-barrel folding on the SAM complex	30
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity	30
When transcription initiation meets chromatin	30
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	30
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	30
Author Correction: RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals	29
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	29
Molecular basis for substrate recognition and transport of human GABA transporter GAT1	29
Breaking the K48-chain: linking ubiquitin beyond protein degradation	29
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	28
Author Correction: Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation	28
Structural basis of human U5 snRNP late biogenesis and recycling	28
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	28
Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases	28
Structural insights into the activation and inhibition of CXC chemokine receptor 3	28
Shifting our perspective on orphan G protein-coupled receptors	27
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway	27
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	27
Protein destabilization underlies pathogenic missense mutations in ARID1B	27
Identifying nature’s smallest fractals	27
Constitutive activation mechanism of a class C GPCR	27
Structure-guided drug discovery: back to the future	27
Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol ε	26
Structural insights into translocation and tailored synthesis of hyaluronan	26
Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization	26
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	25
Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity	25
Snapshots of actin and tubulin folding inside the TRiC chaperonin	25
HP1 shapes embryonic genome architecture	25
Mechanism of actin filament severing and capping by gelsolin	25
Structural insights into SV2A and the mechanism of racetam anticonvulsants	25
LYSET helps put the ‘lys’ in lysosomes	25
ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy	25
Supporting structural biologists in Africa requires resources and capacity building	25

Mesoscale chromatin confinement facilitates target search of pioneer transcription factors in live cells	25
Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization	25
Origins of meiotic recombination	24
A structural atlas for pain relief	24
30 years of structural and molecular biology and counting	24
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	24
Unlatching a window into the molecular landscape of prion toxicity	23
Binding NEMO: Liquid–liquid phase separation captures immune regulator	23
Autophagosomes need calcium	23
Ebola virus L–VP35 structure	23
DNA translocation hinges on cohesin	23
A look into the dynamic process of proofreading in DNA polymerase-γ at near-atomic resolution	23
PIEZOs in vacuoles	23
Extended and exposed enhancer RNAs activate transcription	22
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	22
OCT4 learns new tricks	22
Acetyl-CoA keeps PC stable	22
Natural selection finds a way, even under heavy constraints	22
Publisher Correction: Molnupiravir: coding for catastrophe	22
Nature, more than nurture, of epigenetic states	22
Quantifying how promoter-associated nucleosomes regulate transcriptional bursting	21
A mind-changing approach to the therapeutic use of psychedelics	21
Studying the impact of the nuclear topography on gene function	21
Too much DNA demethylation breaks post-mitotic cells	21
SPT5 roles in transcriptional elongation	21
Temporal and regional X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing	21
The guanylate-binding protein GBP1 forms a protein coat that enwraps cytosol-invasive bacteria	21
Human primase hangs on the primer–template and Polα to facilitate primer termination	21
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates	21
Bumper cars: trailing ribosome accelerates transcribing polymerase	21
From atoms to cells	20
Author Correction: RNA polymerase II pausing regulates chromatin organization in erythrocytes	20
The conformational landscape of human transthyretin revealed by cryo-EM	20
Structure and catalytic mechanism of exogenous fatty acid recycling by AasS, a versatile acyl-ACP synthetase	20
BIDding on PROTACs in an era of antibiotic resistance	20
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	20
Illuminating the role of chaperones in spliceosome biogenesis and recycling	20
A network of interacting ciliary tip proteins with opposing activities imparts slow and processive microtubule growth	20
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	20
Cohesin closes the door on coexpression	20
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	20
Future opportunities in solute carrier structural biology	20
Publisher Correction: HP1 shapes embryonic genome architecture	20
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	20
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	20
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	20
Cryo-EM structure of the human subcortical maternal complex and the associated discovery of infertility-associated variants	19
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin	19
Looking back at the timely launch of Nature Structural Biology in 1994	19
Structural basis of FANCD2 deubiquitination by USP1−UAF1	19
Structural basis of the complete poxvirus transcription initiation process	19
The risky business of ADP-ribosylating telomeric DNA	19
Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily	19
Pack a STRIPAK with hubs inside a hub	19
The structure of a virus-encoded nucleosome	19
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development	19
Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism	19
Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis	19
Author Correction: mRNA structural dynamics shape Argonaute-target interactions	19
Reply to: Reevaluating the role of human mitochondrial uL18m in the cytosolic stress response	18
Could AlphaFold revolutionize chemical therapeutics?	18
Decoupling of degradation from deadenylation reshapes poly(A) tail length in yeast meiosis	18
Mining for METTL3 inhibitors to suppress cancer	18
GPCR activation mechanisms across classes and macro/microscales	18
Structure of the human SAGA coactivator complex	18
Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12	18
Building insights into KRAS signaling complexes	18
Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly	18
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism	18
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	17
Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair	17
How asymmetric DNA replication achieves symmetrical fidelity	17
Ciliary central apparatus structure reveals mechanisms of microtubule patterning	17
Structure of the human GlcNAc-1-phosphotransferase αβ subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation	17
Phase separation drives X-chromosome inactivation	17
The oxytocin signaling complex reveals a molecular switch for cation dependence	17
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies	16
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	16
Structures of transcription preinitiation complex engaged with the +1 nucleosome	16
Switching under selection: how CoREST controls endocrine therapy resistance in ER+ breast cancer	16
Inactive and active state structures template selective tools for the human 5-HT5A receptor	16
Allosteric regulation controls actin-bundling properties of human plastins	16
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	16
EGOC inhibits TOROID polymerization by structurally activating TORC1	16
Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W	16
Architecture of the human erythrocyte ankyrin-1 complex	16
Histone deacetylation primes self-propagation of heterochromatin domains to promote epigenetic inheritance	16
Condensin-driven loop extrusion on supercoiled DNA	16
Human PRPS1 filaments stabilize allosteric sites to regulate activity	16
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation	16
Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels	15
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor	15
Pol X DNA polymerases contribute to NHEJ flexibility	15
Cracking the case of m7G modification in human tRNAs	15
Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis	15