Nature Structural & Molecular Biology

Article	Citations
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	586
30 years of structural and molecular biology and counting	241
Structural basis of branching during RNA splicing	164
Structures of aberrant spliceosome intermediates on their way to disassembly	139
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	122
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	117
Exploration of novel αβ-protein folds through de novo design	115
The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	108
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	104
Surviving under stress conditions	101
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization	98
Author Correction: Polλ promotes microhomology-mediated end-joining	97
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	94
P-type ATPase magnesium transporter MgtA acts as a dimer	92
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site	92
Shifting our perspective on orphan G protein-coupled receptors	91
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	91
Transcription directionality is licensed by Integrator at active human promoters	90
Structural insights into translocation and tailored synthesis of hyaluronan	81
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	79
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	77
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism	77
Charting the 3D regulatory landscape of sex determination with geostatistics	76
Author Correction: Structure and mechanism of antiphage retron Eco2	76
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	75

Endocrine resistance and breast cancer plasticity are controlled by CoREST	71
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	70
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	69
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	69
Protein import into mitochondria — a new path through the membranes	68
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	68
A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients	68
Structure of the HCV glycoprotein	68
Towards a molecular and structural definition of cell death	68
Current challenges in understanding the role of enhancers in disease	67
Gene regulation through exon junction complex modularity	67
Constitutive activation mechanism of a class C GPCR	67
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	64
Accessible technology for diploid high-order 3D human genome analysis	63
Binding NEMO: Liquid–liquid phase separation captures immune regulator	63
Studying the impact of the nuclear topography on gene function	62
Cohesin closes the door on coexpression	61
Cryo-EM structure of an active central apparatus	61
A personal perspective of the voltage-gated potassium channel studies	60
Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development	60
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM	60
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	60
Author Correction: Cryo-EM structure of an active central apparatus	59
Better SIFI than sorry	59
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	59
Author Correction: Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	58
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex	57
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	57
Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport	57
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	56
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	56
SCAF1 drives the compositional diversity of mammalian respirasomes	54
EGOC inhibits TOROID polymerization by structurally activating TORC1	54
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells	53
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes	53
THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development	53
MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy	52
Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex	52
Smc5/6 silences episomal transcription by a three-step function	51
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution	51
Understanding ubiquitination in neurodevelopment by integrating insights across space and time	50
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	50
Structures of transcription preinitiation complex engaged with the +1 nucleosome	49
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	49
The conformational landscape of human transthyretin revealed by cryo-EM	49
Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo	48
Function and regulation of the mitochondrial stress response	48
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics	48
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos	47
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation	47

Checking in on proteostasis	47
Control of transcription elongation and DNA repair by alarmone ppGpp	47
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	47
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers	47
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates	46
Perfect match: PET ligand fits snugly into folded Tau filaments	46
Virtual screen raises hit rate	45
Transcription and replication meet the silent X chromosome territory	44
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure	44
Thirty years of structural changes	44
All roads lead to MRN regulation at telomeres: different paths to one solution	44
TALEDs complete the toolkit for editing human mitochondrial DNA	44
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization	43
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening	43
STING to the lysosome’s rescue	43
Functional epigenomics: chromatin complexity untangled	43
Structural basis for the dynamic chaperoning of disordered clients by Hsp90	42
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation	42
Transcription modulates chromatin dynamics and locus configuration sampling	42
Transport mechanism of presynaptic high-affinity choline uptake by CHT1	42
Structural basis of circularly permuted group II intron self-splicing	42
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies	42
Finding and recycling stalled spliceosomes	41
Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1	40
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation	40
Structure and function of the human mitochondrial MRS2 channel	40
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)	39
Structural basis of hepatitis B virus receptor binding	39
Structure and interactions of the endogenous human Commander complex	39
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants	39
Dynamics of microcompartment formation at the mitosis-to-G1 transition	39
ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network	38
Structural clues about bridge-mediated lipid transfer	38
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37	38
Structure of a volume-regulated heteromeric LRRC8A/C channel	38
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly	38
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC	38
Hallucination of closed repeat proteins containing central pockets	37
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus	37
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine	37
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling	37
Two dynamically competing factors determine the translation start site	37
Structural insights into the iron nitrogenase complex	37
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis	37
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	36
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development	36
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	36
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans	36
Structure of RAS signaling regulator complex reveals mechanism	35
Looking back at 30 years of Nature Structural & Molecular Biology	35
Remote on–off switching of protein activity by intrinsically disordered region	35
MitoPerturb-Seq identifies links between nuclear and mitochondrial genomes in single cells	35
Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs	35
A chromatin mesh model for compaction of chromatin by PRC1 in condensates	35
Regulatory activity is the default DNA state in eukaryotes	35
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1	35
Mechanical disengagement of the cohesin ring	34
Structure and function of a broad-range thermal receptor in myriapods	34
EMProt improves structure determination from cryo-EM maps	34
PARP1 and HPF1 team up to flag down DNA-repair machinery	34
Structural basis of pH-dependent activation in a CLC transporter	34
Ferlin structures	34
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	33
Mechanism and reconstitution of circadian transcription in cyanobacteria	33
Parkinson’s disease risk protein TMEM175 keeps lysosomes running on a proton leak	33
Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides	33
The structure of the NuA4–Tip60 complex reveals the mechanism and importance of long-range chromatin modification	33
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase	33
The yeast genome is globally accessible in living cells	33
Mechanisms for licensing origins of DNA replication in eukaryotic cells	32
Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity	32
Replication licensing during S phase: breaking the law to prevent breaking DNA	32
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis	32
Distinct tau filament folds in human MAPT mutants P301L and P301T	32
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss	32
A nanobody-based therapeutic targeting Nipah virus limits viral escape	32
Molecular basis of the TRAP complex function in ER protein biogenesis	32
De novo design of obligate ABC-type heterotrimeric proteins	32
Actin up: shifting chromosomes toward repair, but also translocations	32
Author Correction: Smc5/6 silences episomal transcription by a three-step function	31

TMEM170 proteins are lipid scramblases associated with bridge-type lipid transporters BLTP1/Csf1	31
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing	31
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence	31
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia	31
Structural insights into the regulation of Cas7-11 by TPR-CHAT	31
Returning home to navigate challenges and meet potential in Poland	31
Menopause age and cancer risk is influenced by rare genetic variants	31
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication	31
Mapping the conformational landscape of the stimulatory heterotrimeric G protein	31
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W	31
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate	31
Kinetic control of mammalian transcription elongation	31
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis	31
Regulation of kinesin-2 motility by its β-hairpin motif	31
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation	30
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function	30
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor	30
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families	30
Extending guide RNA length restores high-fidelity CRISPR–Cas9 activity	30
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex	30
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets	29
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA	29
Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta	29
How one molecule senses light and temperature	29
Mechanism of mammalian transcriptional repression by noncoding RNA	29
Towards a structurally resolved human protein interaction network	29
Cryo-EM structures of the Spo11 core complex bound to DNA	29
Structural insights into TRPV2 modulation by probenecid	29
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1	29
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells	29
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity	29
Building a molecular rotor	29
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	28
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	28
Structural basis for retron co-option of anti-phage ATPase-nuclease	28
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	28
An egg-ceptional mechanism of acentrosomal spindle assembly	28
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	28
Neuronal VPS13D loss drives microglial activation	28
Space exploration: finding new protein conformations using AlphaFold2	28
The molecular basis of lamin-specific chromatin interactions	27
A conformational switch controlling the toxicity of the prion protein	27
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	27
A unifying model for membrane protein biogenesis	27
Structure of the γ-tubulin ring complex-capped microtubule	27
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	27
Structural insights into SV2A and the mechanism of racetam anticonvulsants	27
Structural basis for CaVα2δ:gabapentin binding	27
Exposing chromothripsis	27
From atoms to cells	26
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	26
Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels	26
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	26
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas	26
Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel	26
Ebola virus L–VP35 structure	26
Human primase hangs on the primer–template and Polα to facilitate primer termination	26
Closing 2025, and a look ahead	26
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals	26
Computational design of sequence-specific DNA-binding proteins	26
Cracking the case of m7G modification in human tRNAs	26
Building up complexity in structural biology studies	26
Caught in the act: how a brake on cell growth is anchored to lysosomes	26
A snapshot of proteostasis in human oocytes	25
AlphaFold3 takes a step toward decoding molecular behavior and biological computation	25
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation	25
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor	25
Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome	25
Architecture of the ESCPE-1 membrane coat	25
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis	25
The impact of DNA methylation on CTCF-mediated 3D genome organization	25
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	24
Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis	24
No stasis in proteostasis	24
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling	24
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis	24
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	24
Natural selection finds a way, even under heavy constraints	24
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation	23
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase	23
A negative feedback mechanism controls histone gene expression	23
Future opportunities in solute carrier structural biology	23
The RNA world	23
ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility	23
An in vivo platform to screen for regulators of Huntington’s disease	23
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair	23
Membrane-embedded machines	23
Looking back at 2023	23
Structural basis for membrane remodeling by the AP5–SPG11–SPG15 complex	22
A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR	22
Structures of the ribosome bound to EF-Tu–isoleucine tRNA elucidate the mechanism of AUG avoidance	22
Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1	22
Cytoskeleton organizes nucleus	22
The essential functions of protein SUMOylation in cell proliferation	22
Structural basis of sequence-specific cytosine deamination by double-stranded DNA deaminase toxin DddA	22