Nature Structural & Molecular Biology

Article	Citations
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis	495
A structural biology community assessment of AlphaFold2 applications	317
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers	304
AlphaFold2 and the future of structural biology	238
Can AlphaFold2 predict the impact of missense mutations on structure?	214
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation	189
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs	182
Structural basis for broad coronavirus neutralization	154
GPCR activation mechanisms across classes and macro/microscales	143
Heat-dependent opening of TRPV1 in the presence of capsaicin	129
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function	128
Towards a structurally resolved human protein interaction network	121
Molnupiravir: coding for catastrophe	117
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent	111
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin	111
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS	111
It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation	110
Dnmt1 has de novo activity targeted to transposable elements	106
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes	99
Structures of radial spokes and associated complexes important for ciliary motility	99
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome	94
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel	89
PARP inhibition impedes the maturation of nascent DNA strands during DNA replication	87
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads	87
Structural basis of nucleosome transcription mediated by Chd1 and FACT	85

Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs	83
Structural insights into the regulation of human serine palmitoyltransferase complexes	74
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes	72
Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression	66
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism	65
Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex	65
Cold sensitivity of the SARS-CoV-2 spike ectodomain	64
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency	64
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states	63
Mechanistic insight into substrate processing and allosteric inhibition of human p97	63
The structural basis of fatty acid elongation by the ELOVL elongases	62
Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis	62
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1	62
The coupling mechanism of mammalian mitochondrial complex I	61
The case for post-predictional modifications in the AlphaFold Protein Structure Database	61
Structural basis of RNA processing by human mitochondrial RNase P	60
Conformational buffering underlies functional selection in intrinsically disordered protein regions	60
Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB	60
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome	59
Regulation of translation by site-specific ribosomal RNA methylation	59
DNA-loop-extruding SMC complexes can traverse one another in vivo	58
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution	58
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores	58
Structure determination of inactive-state GPCRs with a universal nanobody	58
DNA interference states of the hypercompact CRISPR–CasΦ effector	58
Reprogramming of the histone H3.3 landscape in the early mouse embryo	57
Cryo-EM structures of Toll-like receptors in complex with UNC93B1	57
Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily	54
TET2 chemically modifies tRNAs and regulates tRNA fragment levels	53
Structural and functional characterization of the Spo11 core complex	51
Target-induced clustering activates Trim-Away of pathogens and proteins	51
Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory	49
Cohesin is required for long-range enhancer action at the Shh locus	49
Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol	49
Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers	49
Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62	49
Structural mechanism of muscle nicotinic receptor desensitization and block by curare	48
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	48
The structure of a virus-encoded nucleosome	48
A structural model of a Ras–Raf signalosome	47
Retinoic acid signaling is critical during the totipotency window in early mammalian development	47
Ciliary central apparatus structure reveals mechanisms of microtubule patterning	47
Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating	46
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	46
Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry	44
The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains	44
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	44
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	44
Molecular basis for kinin selectivity and activation of the human bradykinin receptors	44
Kinetic principles underlying pioneer function of GAGA transcription factor in live cells	44

Cryo-EM structure of the human MT1–Gi signaling complex	44
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans	44
Cryo-EM structure of an active central apparatus	43
Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins	43
Architecture of the human erythrocyte ankyrin-1 complex	43
Seipin forms a flexible cage at lipid droplet formation sites	43
Single-stranded nucleic acid binding and coacervation by linker histone H1	42
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres	42
CRISPR–Cas9 bends and twists DNA to read its sequence	42
Synergistic activation of the insulin receptor via two distinct sites	42
Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops	40
Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation	40
Cryo-EM structure of the Hippo signaling integrator human STRIPAK	40
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition	40
A first exon termination checkpoint preferentially suppresses extragenic transcription	39
Structural basis for bacterial lipoprotein relocation by the transporter LolCDE	38
Alternative polyadenylation by sequential activation of distal and proximal PolyA sites	38
Structural insights into transcriptional regulation of human RNA polymerase III	37
A cohesin traffic pattern genetically linked to gene regulation	37
CENP-N promotes the compaction of centromeric chromatin	37
A pioneer factor locally opens compacted chromatin to enable targeted ATP-dependent nucleosome remodeling	37
Structure of the human SAGA coactivator complex	37
Molecular organization of the E. coli cellulose synthase macrocomplex	36
A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation	36
ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy	36
Structural insights into binding of therapeutic channel blockers in NMDA receptors	35
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism	34
Condensin-driven loop extrusion on supercoiled DNA	34
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics	34
Could AlphaFold revolutionize chemical therapeutics?	34
Structural basis for DNA targeting by the Tn7 transposon	33
Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2	33
Current challenges in understanding the role of enhancers in disease	33
Molecular basis of human ATM kinase inhibition	33
IMPDH1 retinal variants control filament architecture to tune allosteric regulation	33
Scaffolding protein CcmM directs multiprotein phase separation in β-carboxysome biogenesis	32
Snapshots of actin and tubulin folding inside the TRiC chaperonin	32
In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes	32
The oxytocin signaling complex reveals a molecular switch for cation dependence	32
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	32
Structural basis and mechanism of activation of two different families of G proteins by the same GPCR	32
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization	32
An atypical RNA quadruplex marks RNAs as vectors for gene silencing	31
Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis	31
Deciphering the mechanical code of the genome and epigenome	31
Imbalances in the eye lens proteome are linked to cataract formation	31
Structural basis of FANCD2 deubiquitination by USP1−UAF1	31
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins	30
Cryo-EM structures of human RNA polymerase I	30
Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids	30
Structure of the FA core ubiquitin ligase closing the ID clamp on DNA	29
The tertiary structure of the human Xkr8–Basigin complex that scrambles phospholipids at plasma membranes	29
Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation	29
Regulation of human trophoblast gene expression by endogenous retroviruses	29
Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules	28
Plasticity in ligand recognition at somatostatin receptors	28
HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage	28
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	28
The selection process of licensing a DNA mismatch for repair	27
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase	27
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119	27
Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis	27
Screening thousands of transcribed coding and non-coding regions reveals sequence determinants of RNA polymerase II elongation potential	27
Structures of transcription preinitiation complex engaged with the +1 nucleosome	27
Mechanisms of loading and release of the 9-1-1 checkpoint clamp	26
Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome	26
The Mediator complex regulates enhancer-promoter interactions	26
A critical period of translational control during brain development at codon resolution	26
Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane	26
The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities	25
Structural insight into apelin receptor-G protein stoichiometry	25
Structural insights into assembly and function of the RSC chromatin remodeling complex	25
Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery	25
Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels	25
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1	25
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	25
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly	25
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation	25
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans	24
The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes	24

Structural conservation of antibiotic interaction with ribosomes	24
The structural basis of PTEN regulation by multi-site phosphorylation	24
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state	24
Structural basis of CHMP2A–CHMP3 ESCRT-III polymer assembly and membrane cleavage	24
Structure of the human cone photoreceptor cyclic nucleotide-gated channel	24
Scaling analysis reveals the mechanism and rates of prion replication in vivo	24
Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2	23
Molecular pathway of mitochondrial preprotein import through the TOM–TIM23 supercomplex	23
Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12	23
Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation	23
Gene regulation on extrachromosomal DNA	23
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair	22
Mining for METTL3 inhibitors to suppress cancer	22
Global, in situ analysis of the structural proteome in individuals with Parkinson’s disease to identify a new class of biomarker	22
Smc5/6 silences episomal transcription by a three-step function	22
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity	22
Structural biology in the fight against COVID-19	22
Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly	22
Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2	21
De novo design of tyrosine and serine kinase-driven protein switches	21
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect	21
Structure of a volume-regulated heteromeric LRRC8A/C channel	21
Histone deacetylation primes self-propagation of heterochromatin domains to promote epigenetic inheritance	21
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation	20
The multi-functional Smc5/6 complex in genome protection and disease	20
Kicking off sphingolipid biosynthesis: structures of the serine palmitoyltransferase complex	20
DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp	20
Inactive and active state structures template selective tools for the human 5-HT5A receptor	20
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress	20
Anionic lipids unlock the gates of select ion channels in the pacemaker family	20
Three-dimensional genome organization via triplex-forming RNAs	20
A molecular switch modulates assembly and host factor binding of the HIV-1 capsid	20
Molecular basis for substrate recognition and transport of human GABA transporter GAT1	19
Fungicidal amphotericin B sponges are assemblies of staggered asymmetric homodimers encasing large void volumes	19
Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase	19
A conformational switch controlling the toxicity of the prion protein	19
Making the invisible enemy visible	19
Short- and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging	19
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH	19
A multipoint guidance mechanism for β-barrel folding on the SAM complex	18
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13	18
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function	18
Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization	18
How asymmetric DNA replication achieves symmetrical fidelity	18
An online GPCR structure analysis platform	18
Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4–NOT	18
Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting	18
The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods	17
Phase separation drives X-chromosome inactivation	17
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	17
Structural basis of phosphatidylinositol 3-kinase C2α function	17
Sequence-specific remodeling of a topologically complex RNP substrate by Spb4	17
m6A governs length-dependent enrichment of mRNAs in stress granules	17
Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments	17
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies	17
Structural basis for NaV1.7 inhibition by pore blockers	17
The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination	16
Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism	16
Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels	16
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing	16
Structures of human primosome elongation complexes	16
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization	16
The structure-specific endonuclease complex SLX4–XPF regulates Tus–Ter-induced homologous recombination	16
Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand	16
Higher-order phosphatase–substrate contacts terminate the integrated stress response	16
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	15
De novo design of obligate ABC-type heterotrimeric proteins	15
A single 2′-O-methylation of ribosomal RNA gates assembly of a functional ribosome	15
Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1	15
Structural basis for CaVα2δ:gabapentin binding	15
Structural basis for RNA slicing by a plant Argonaute	15
Compartmentalization of the replication fork by single-stranded DNA-binding protein regulates translesion synthesis	15
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development	15
Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN	15
Readout of histone methylation by Trim24 locally restricts chromatin opening by p53	15
Endocrine resistance and breast cancer plasticity are controlled by CoREST	15
SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity	15
Replication fork uncoupling causes nascent strand degradation and fork reversal	15
Acetylation-dependent SAGA complex dimerization promotes nucleosome acetylation and gene transcription	15
Structure of human glycosylphosphatidylinositol transamidase	15
Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth	14
DNA segment capture by Smc5/6 holocomplexes	14
The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A	14
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex	14
Molecular basis of the TRAP complex function in ER protein biogenesis	14
DELE1 oligomerization promotes integrated stress response activation	14
Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair	14
Polarity of the CRISPR roadblock to transcription	14
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	14
Structural biases in disordered proteins are prevalent in the cell	13
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	13
CTCF blocks antisense transcription initiation at divergent promoters	13
Structural basis of the complete poxvirus transcription initiation process	13
Brominated lipid probes expose structural asymmetries in constricted membranes	13
Mechanism of receptor assembly via the pleiotropic adipokine Leptin	13