Nature Structural & Molecular Biology

Article	Citations
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	564
Structural insights into metazoan pretargeting GET complexes	408
Transcription directionality is licensed by Integrator at active human promoters	277
The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	261
Author Correction: Polλ promotes microhomology-mediated end-joining	203
Surviving under stress conditions	194
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	172
Structure of the HCV glycoprotein	171
Endocrine resistance and breast cancer plasticity are controlled by CoREST	161
HP1 shapes embryonic genome architecture	142
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	137
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	126
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	119
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	116
Accessible technology for diploid high-order 3D human genome analysis	114
30 years of structural and molecular biology and counting	114
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	112
Structural basis of branching during RNA splicing	112
Snapshots of actin and tubulin folding inside the TRiC chaperonin	108
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site	88
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	81
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	80
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	77
Current challenges in understanding the role of enhancers in disease	76
Structures of aberrant spliceosome intermediates on their way to disassembly	76

Protein import into mitochondria — a new path through the membranes	76
Exploration of novel αβ-protein folds through de novo design	74
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	74
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress	74
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	73
Structural insights into translocation and tailored synthesis of hyaluronan	72
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation	72
Constitutive activation mechanism of a class C GPCR	71
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	71
Shifting our perspective on orphan G protein-coupled receptors	71
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	70
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	69
Binding NEMO: Liquid–liquid phase separation captures immune regulator	67
Studying the impact of the nuclear topography on gene function	67
Nature, more than nurture, of epigenetic states	66
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	65
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	64
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates	62
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	62
Phase separation drives X-chromosome inactivation	62
Understanding ubiquitination in neurodevelopment by integrating insights across space and time	61
SCAF1 drives the compositional diversity of mammalian respirasomes	60
Structures of transcription preinitiation complex engaged with the +1 nucleosome	59
Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair	58
Cryo-EM structure of an active central apparatus	54
Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport	54
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	54
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos	54
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers	54
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells	53
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes	52
EGOC inhibits TOROID polymerization by structurally activating TORC1	52
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	51
Author Correction: Cryo-EM structure of an active central apparatus	51
Reply to: Reevaluating the role of human mitochondrial uL18m in the cytosolic stress response	51
Control of transcription elongation and DNA repair by alarmone ppGpp	51
Building insights into KRAS signaling complexes	50
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM	49
A personal perspective of the voltage-gated potassium channel studies	48
Cohesin closes the door on coexpression	47
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation	47
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	47
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	47
The conformational landscape of human transthyretin revealed by cryo-EM	46
Smc5/6 silences episomal transcription by a three-step function	46
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution	46
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism	45
THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development	45
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	45
CENP-N promotes the compaction of centromeric chromatin	44

TALEDs complete the toolkit for editing human mitochondrial DNA	44
Perfect match: PET ligand fits snugly into folded Tau filaments	44
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening	44
Transport mechanism of presynaptic high-affinity choline uptake by CHT1	43
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly	43
Structure and interactions of the endogenous human Commander complex	43
The coupling mechanism of mammalian mitochondrial complex I	43
Finding and recycling stalled spliceosomes	43
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants	43
Structural basis of hepatitis B virus receptor binding	43
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure	42
Structure and function of the human mitochondrial MRS2 channel	42
Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1	41
All roads lead to MRN regulation at telomeres: different paths to one solution	41
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)	41
Functional epigenomics: chromatin complexity untangled	41
Thirty years of structural changes	40
Transcription and replication meet the silent X chromosome territory	40
Virtual screen raises hit rate	40
Structural basis for the dynamic chaperoning of disordered clients by Hsp90	39
Structural basis of circularly permuted group II intron self-splicing	39
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies	39
ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network	39
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation	39
Evolution of a histone variant involved in compartmental regulation of NAD metabolism	38
The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes	37
Diverse activation mechanisms of PI3Ks	36
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads	36
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation	36
Transcription modulates chromatin dynamics and locus configuration sampling	36
Making the invisible enemy visible	36
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization	36
MacroH2A1.1 has evolved to let PARP1 do more by loosening its grip on PAR	35
Mitoribosome assembly comes into view	34
DNA replication at high res	34
De novo design of tyrosine and serine kinase-driven protein switches	34
Synergies between the Protein Data Bank and the community	34
Looking back at 2021	34
Fusion proteins form onco-condensates	34
Cryptic elements of the heat-shock response	34
Hallucination of closed repeat proteins containing central pockets	33
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine	33
Molecular basis of human ATM kinase inhibition	33
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling	33
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans	33
Structure of a volume-regulated heteromeric LRRC8A/C channel	32
Regulatory activity is the default DNA state in eukaryotes	32
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC	31
The structural basis of fatty acid elongation by the ELOVL elongases	31
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus	31
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development	31
Cryo-EM structures of human RNA polymerase I	31
Structural insights into the iron nitrogenase complex	31
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	30
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	30
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase	30
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis	30
Molting mitochondria	29
Parkinson’s disease risk protein TMEM175 keeps lysosomes running on a proton leak	29
Structure of RAS signaling regulator complex reveals mechanism	29
A chromatin mesh model for compaction of chromatin by PRC1 in condensates	29
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis	29
Mechanical disengagement of the cohesin ring	28
De novo design of obligate ABC-type heterotrimeric proteins	28
Looking back at 30 years of Nature Structural & Molecular Biology	28
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	28
Structure and function of a broad-range thermal receptor in myriapods	28
PARP1 and HPF1 team up to flag down DNA-repair machinery	28
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase	28
A tweak and a peek: How Cas9 pries open double-stranded DNA to check its sequence	28
The yeast genome is globally accessible in living cells	27
Cryo-EM structure of the human MT1–Gi signaling complex	27
Structural insights into TRPV2 modulation by probenecid	27
Molecular basis of the TRAP complex function in ER protein biogenesis	27
Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides	27
Author Correction: Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation	27
The structure of the NuA4–Tip60 complex reveals the mechanism and importance of long-range chromatin modification	27
Structural basis of pH-dependent activation in a CLC transporter	27
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence	27
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex	27

Mechanism of mammalian transcriptional repression by noncoding RNA	26
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss	26
Actin up: shifting chromosomes toward repair, but also translocations	26
Menopause age and cancer risk is influenced by rare genetic variants	26
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis	26
Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta	26
Author Correction: Smc5/6 silences episomal transcription by a three-step function	26
Replication licensing during S phase: breaking the law to prevent breaking DNA	26
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W	25
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1	25
Structural insights into the regulation of Cas7-11 by TPR-CHAT	25
Mapping the conformational landscape of the stimulatory heterotrimeric G protein	25
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication	25
Cryo-EM structures of the Spo11 core complex bound to DNA	25
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function	25
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation	24
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets	24
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor	24
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families	24
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia	24
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate	23
Towards a structurally resolved human protein interaction network	23
Structural insights into SV2A and the mechanism of racetam anticonvulsants	23
How one molecule senses light and temperature	23
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins	23
Exposing chromothripsis	23
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing	23
Building a molecular rotor	23
Space exploration: finding new protein conformations using AlphaFold2	23
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity	23
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells	23
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA	23
An egg-ceptional mechanism of acentrosomal spindle assembly	23
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	22
Structure of the γ-tubulin ring complex-capped microtubule	22
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	22
Structural basis for CaVα2δ:gabapentin binding	22
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	22
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	22
A unifying model for membrane protein biogenesis	22
Fatty acid elongation by ELOVL condensing enzymes depends on a histidine nucleophile	22
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	22
A conformational switch controlling the toxicity of the prion protein	22
Plasticity in ligand recognition at somatostatin receptors	22
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	22
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair	21
Cracking the case of m7G modification in human tRNAs	21
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function	21
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	21
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	21
Decoupling of degradation from deadenylation reshapes poly(A) tail length in yeast meiosis	21
PIEZOs in vacuoles	21
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution	21
Human primase hangs on the primer–template and Polα to facilitate primer termination	21
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	21
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation	21
Natural selection finds a way, even under heavy constraints	21
Ebola virus L–VP35 structure	21
From atoms to cells	21
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals	20
Future opportunities in solute carrier structural biology	20
Could AlphaFold revolutionize chemical therapeutics?	20
Building up complexity in structural biology studies	20
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling	20
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis	20
Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels	20
Author Correction: mRNA structural dynamics shape Argonaute-target interactions	20
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation	20
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor	19
Architecture of the ESCPE-1 membrane coat	19
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis	19
Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12	19
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas	19
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase	19
AlphaFold3 takes a step toward decoding molecular behavior and biological computation	19
Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome	19
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	19
The impact of DNA methylation on CTCF-mediated 3D genome organization	19
Looking back at 2023	18
An in vivo platform to screen for regulators of Huntington’s disease	18
The essential functions of protein SUMOylation in cell proliferation	18
Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice	18
Membrane-embedded machines	18
Quantitative analysis of transcription start site selection reveals control by DNA sequence, RNA polymerase II activity and NTP levels	18
Cytoskeleton organizes nucleus	18
Higher-order phosphatase–substrate contacts terminate the integrated stress response	18
Three-dimensional genome organization via triplex-forming RNAs	18
Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1	18
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1	18
The RNA world	18
Reevaluating the role of human mitochondrial uL18m in the cytosolic stress response	18
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH	17
A cohesin traffic pattern genetically linked to gene regulation	17
Dnmt1 has de novo activity targeted to transposable elements	17
A pioneer factor locally opens compacted chromatin to enable targeted ATP-dependent nucleosome remodeling	17