OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Structural & Molecular Biology is 53. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis	495
A structural biology community assessment of AlphaFold2 applications	317
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers	304
AlphaFold2 and the future of structural biology	238
Can AlphaFold2 predict the impact of missense mutations on structure?	214
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation	189
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs	182
Structural basis for broad coronavirus neutralization	154
GPCR activation mechanisms across classes and macro/microscales	143
Heat-dependent opening of TRPV1 in the presence of capsaicin	129
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function	128
Towards a structurally resolved human protein interaction network	121
Molnupiravir: coding for catastrophe	117
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin	111
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS	111
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent	111
It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation	110
Dnmt1 has de novo activity targeted to transposable elements	106
Structures of radial spokes and associated complexes important for ciliary motility	99
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes	99
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome	94
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel	89
PARP inhibition impedes the maturation of nascent DNA strands during DNA replication	87
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads	87
Structural basis of nucleosome transcription mediated by Chd1 and FACT	85

Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs	83
Structural insights into the regulation of human serine palmitoyltransferase complexes	74
Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes	72
Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression	66
Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex	65
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism	65
Cold sensitivity of the SARS-CoV-2 spike ectodomain	64
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency	64
Mechanistic insight into substrate processing and allosteric inhibition of human p97	63
Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states	63
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1	62
The structural basis of fatty acid elongation by the ELOVL elongases	62
Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis	62
The case for post-predictional modifications in the AlphaFold Protein Structure Database	61
The coupling mechanism of mammalian mitochondrial complex I	61
Conformational buffering underlies functional selection in intrinsically disordered protein regions	60
Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB	60
Structural basis of RNA processing by human mitochondrial RNase P	60
Regulation of translation by site-specific ribosomal RNA methylation	59
Xist spatially amplifies SHARP/SPEN recruitment to balance chromosome-wide silencing and specificity to the X chromosome	59
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores	58
Structure determination of inactive-state GPCRs with a universal nanobody	58
DNA interference states of the hypercompact CRISPR–CasΦ effector	58
DNA-loop-extruding SMC complexes can traverse one another in vivo	58
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution	58
Cryo-EM structures of Toll-like receptors in complex with UNC93B1	57
Reprogramming of the histone H3.3 landscape in the early mouse embryo	57
Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily	54
TET2 chemically modifies tRNAs and regulates tRNA fragment levels	53