OOIR: Observatory of International Research

Papers

(The median citation count of Clinical Proteomics is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
From blood drops to biomarkers: a scoping review of microsampling in mass spectrometry-based proteomics	132
Recent progress in mass spectrometry-based urinary proteomics	44
Changes of serum IgG glycosylation patterns in rheumatoid arthritis	40
Comparative proteomic analysis of glomerular proteins in primary and bucillamine-induced membranous nephropathy	28
The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies	26
CSF levels of brain-derived proteins correlate with brain ventricular volume in cognitively healthy 70-year-olds	26
Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue	26
Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka	26
Quantification of putative ovarian cancer serum protein biomarkers using a multiplexed targeted mass spectrometry assay	25
Correction: Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients	24
Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model	24
Data-independent acquisition mass spectrometry in severe rheumatic heart disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases	23
Serum proteomics for the identification of biomarkers to flag predilection of COVID19 patients to various organ morbidities	20
Proteomic alteration of endometrial tissues during secretion in polycystic ovary syndrome may affect endometrial receptivity	20
Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer’s disease biomarkers	19
Plasma exosome proteomics reveals upregulation of CILP-1 in concave side of paraspinal muscle in adolescent idiopathic scoliosis	19
Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue	18
An ALS assembly modulator signature in peripheral blood mononuclear cells: implications for ALS pathophysiology, therapeutics, and diagnostics	18
Quantitative site-specific N-glycosylation analysis reveals IgG glyco-signatures for pancreatic cancer diagnosis	16
Elevated level of multibranched complex glycan reveals an allergic tolerance status	16
Alterations in the pH of pancreatic juice are associated with chymotrypsin C inactivation and lithostathine precipitation in chronic pancreatitis patients: a proteomic approach	14
Discovery of novel glioma serum biomarkers by proximity extension assay	14
Proteomic characteristics and diagnostic potential of exhaled breath particles in patients with COVID-19	14
Proteomic profiles screening identified novel exosomal protein biomarkers for diagnosis of lung cancer	13
Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: a cross-sectional case–control study	13

Correction: A SISCAPA-based approach for detection of SARS-CoV-2 viral antigens from clinical samples	12
Neat plasma proteomics: getting the best out of the worst	11
Plasma proteomics in pediatric patients with sepsis– hopes and challenges	11
Proteomic analyses reveal cystatin c is a promising biomarker for evaluation of systemic lupus erythematosus	11
Proteomics study of primary and recurrent adamantinomatous craniopharyngiomas	10
Many kinds of oxidized proteins are present more in the urine of the elderly	10
Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology	10
Proteomic insights into the pathophysiology of hypertension-associated albuminuria: Pilot study in a South African cohort	10
Longitudinal serum proteomics identifies inflammatory and metabolic pathways in hypertensive nephrosclerosis progression	10
Quantitative proteomics analysis in small cell carcinoma of cervix reveals novel therapeutic targets	9
Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response	9
Causal effects and mediation pathways of circulating plasma proteins on osteoporosis: a two-sample and two-step Mendelian randomization study	9
Phospho-heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection	9
Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients	9
sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides	9
Recent developments in mass-spectrometry-based targeted proteomics of clinical cancer biomarkers	9
Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers	9
Label-free LC–MS/MS proteomics analyses reveal proteomic changes in oxidative stress and the SOD antioxidant strategy in TM cells	9
Characterizing age-related changes in intact mitochondrial proteoforms in murine hearts using quantitative top-down proteomics	9
The novel biomarkers for assessing clinical benefits of continuous renal replacement therapy in pediatric sepsis: a pilot study	9
Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex	8
Decreased histidine-rich glycoprotein and increased complement C4-B protein levels in follicular fluid predict the IVF outcomes of recurrent spontaneous abortion	8
Plasma proteomics in septic shock and alcohol-related pancreatitis: a hyaluronan-centered approach	8
Integrating multimodal data to predict the progression of hormone-sensitive prostate cancer	8
Integrating functional proteomics and next generation sequencing reveals potential therapeutic targets for Taiwanese breast cancer	8
SPOT: spatial proteomics through on-site tissue-protein-labeling	8
Quantitative proteomic analysis of HER2 protein expression in PDAC tumors	8
Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization	8
ARTN and CCL23 predicted chemosensitivity in acute myeloid leukemia: an Olink® proteomics approach	8
Proteomic analysis of plasma exosomes in patients with metastatic colorectal cancer	7
Human tear film protein sampling using soft contact lenses	7
Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls	7
Quantitative proteomic analysis of serum-purified exosomes identifies putative pre-eclampsia-associated biomarkers	7
Identification of adrenocorticotropic hormone–specific therapeutic biomarkers in infantile epileptic spasm syndrome using data-independent acquisition mass spectrometry	7
Identification of biomarkers of chronic kidney disease among kidney-derived proteins	7
Medwakh smoking induces alterations in salivary proteins and cytokine expression: a clinical exploratory proteomics investigation	7
Urinary exosomal RAB11A serves as a novel non-invasive biomarker for diagnosis, treatment response monitoring, and prognosis in small cell lung cancer	7
A novel non-invasive method allowing for discovery of pathologically relevant proteins from small airways	7
Development of a rapid and specific MALDI-TOF mass spectrometric assay for SARS-CoV-2 detection	7
Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling	7
Novel plasma protein biomarkers from critically ill sepsis patients	7
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers	7
Proteomic profiling of extracellular vesicles derived from human serum for the discovery of biomarkers in Avascular necrosis	7
Spatial top-down proteomics for the functional characterization of human kidney	6
Absolute quantitation of human wild-type DNAI1 protein in lung tissue using a nanoLC-PRM-MS-based targeted proteomics approach coupled with immunoprecipitation	6
Proteomic analysis identifies subgroups of patients with active systemic lupus erythematosus	6
Closing the gaps in patient management of dyslipidemia: stepping into cardiovascular precision diagnostics with apolipoprotein profiling	6
Correction to: A novel non‑invasive method allowing for discovery of pathologically relevant proteins from small airways	6
New mechanisms and biomarkers of lymph node metastasis in cervical cancer: reflections from plasma proteomics	6
Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry	6

An LC–MS-based designated comparison method with similar performance to the Lp(a) reference measurement procedure to guide molar Lp(a) standardization	6
Identification of serum N-glycans signatures in three major gastrointestinal cancers by high-throughput N-glycome profiling	6
Mass spectrometry-based proteomics as an emerging tool in clinical laboratories	6
Frontiers in plasma proteome profiling platforms: innovations and applications	6
Assessing the consistency of mass spectrometry, a clinical-laboratory model, and immunohistochemistry in amyloid subtyping: a Brazilian experience	6
Spatial proteomics to discover aging-associated alterations in the renal tubulointerstitium	6
Transcriptome profiling and proteomic validation reveals targets of the androgen receptor signaling in the BT-474 breast cancer cell line	5
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals	5
Functional and quantitative evaluation of the 20S proteasome in serum and intracellular in145 moroccan patients with hematologic malignancies	5
Combination of automated sample preparation and micro-flow LC–MS for high-throughput plasma proteomics	5
The rapid detection of procalcitonin in septic serum using immunoaffinity MALDI chips	5
Proteomic signature associated with chronic kidney disease (CKD) progression identified by data-independent acquisition mass spectrometry	5
Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics	5
Optimized data-independent acquisition approach for proteomic analysis at single-cell level	5
Using established biorepositories for emerging research questions: a feasibility study	5
Correction to: Using phosphoproteomics data to understand cellular signaling: a comprehensive guide to bioinformatics resources	5
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases	5
Proteome analysis of CD5-positive diffuse large B cell lymphoma FFPE tissue reveals downregulation of DDX3X, DNAJB1, and B cell receptor signaling pathway proteins including BTK and Immunoglobulins	5
Redefining serological diagnostics with immunoaffinity proteomics	5
Application of urine proteomics in the diagnosis and treatment effectiveness monitoring of early-stage Mycosis Fungoides	5
Exploring the novel duo of Reticulocalbin, and Sideroflexin as future biomarker candidates for Exacerbated Chronic Obstructive Pulmonary Disease	5
Identification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicine	4
Unveiling the protein landscape for early detection of colorectal precancerous lesions	4
Investigation on the mechanisms of human sperm DNA damage based on the proteomics analysis by SWATH-MS	4
Identification of circular RNA BTBD7_hsa_circ_0000563 as a novel biomarker for coronary artery disease and the functional discovery of BTBD7_hsa_circ_0000563 based on peripheral blood mononuclear cell	4
Early detection of breast cancer through the diagnosis of Nipple Aspirate Fluid (NAF)	4
Proteomic profile and predictive markers of outcome in patients with subarachnoid hemorrhage	4
Comparative proteomic analysis of glomerular proteins in IgA nephropathy and IgA vasculitis with nephritis	4
OmicsOne: associate omics data with phenotypes in one-click	4
Proteomic profiles in the aqueous following anti-vegf therapy in treatment naïve neovascular age-related macular degeneration	4
Proteomic analysis of low- and high-grade human colon adenocarcinoma tissues and tissue-derived primary cell lines reveals unique biological functions of tumours and new protein biomarker candidates	4
Identification of SARS-CoV-2 biomarkers in saliva by transcriptomic and proteomics analysis	4
Neoplastic cell enrichment of tumor tissues using coring and laser microdissection for proteomic and genomic analyses of pancreatic ductal adenocarcinoma	4
TMT-based proteomic analysis of radiation lung injury in rats	4
Tailored therapeutic decision of rheumatoid arthritis using proteomic strategies: how to start and when to stop?	4
Combined urine proteomics and metabolomics analysis for the diagnosis of pulmonary tuberculosis	4
Differentiation between descending thoracic aortic diseases using machine learning and plasma proteomic signatures	4
Change of histone H3 lysine 14 acetylation stoichiometry in human monocyte derived macrophages as determined by MS-based absolute targeted quantitative proteomic approach: HIV infection and methamphet	3
Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals	3
Label-free quantitative proteomic analysis of serum exosomes from patients of renal anemia: The Good and the Bad of Roxadustat	3
The effect of storage time and temperature on the proteomic analysis of FFPE tissue sections	3
Use of MS-GUIDE for identification of protein biomarkers for risk stratification of patients with prostate cancer	3
Maternal serum CFHR4 protein as a potential non-invasive marker of ventricular septal defects in offspring: evidence from a comparative proteomics study	3
Orthogonal proteomics methods warrant the development of Duchenne muscular dystrophy biomarkers	3
Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study	3
Mapping dynamic molecular changes in hippocampal subregions after traumatic brain injury through spatial proteomics	3
Circulating proteins as predictive and prognostic biomarkers in breast cancer	3
A proteomic profile of the healthy human placenta	3
Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders	3
Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy	3
Combined proteomic/transcriptomic signature of recurrence post-liver transplantation for hepatocellular carcinoma beyond Milan	3
Cord blood platelet-rich plasma: proteomics analysis for ophthalmic applications	3