OOIR: Observatory of International Research

Papers

(The median citation count of Clinical Proteomics is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Recent advances in mass spectrometry based clinical proteomics: applications to cancer research	159
Targeted mass spectrometry to quantify brain-derived cerebrospinal fluid biomarkers in Alzheimer’s disease	52
A comprehensive systematic review of CSF proteins and peptides that define Alzheimer’s disease	38
Mass spectrometry-based microbiological testing for blood stream infection	38
Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues	37
Using phosphoproteomics data to understand cellular signaling: a comprehensive guide to bioinformatics resources	33
CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis	26
Proteomic analysis of synovial fluid from rheumatic arthritis and spondyloarthritis patients	25
Effects of cryopreservation and long-term culture on biological characteristics and proteomic profiles of human umbilical cord-derived mesenchymal stem cells	20
Circulating proteins as predictive and prognostic biomarkers in breast cancer	19
Clinical proteomics for prostate cancer: understanding prostate cancer pathology and protein biomarkers for improved disease management	19
Proteomic analysis of human synovial fluid reveals potential diagnostic biomarkers for ankylosing spondylitis	19
Urinary proteomics of Henoch-Schönlein purpura nephritis in children using liquid chromatography-tandem mass spectrometry	19
Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction	18
The plasma peptides of Alzheimer’s disease	18
Tear proteomic profile in three distinct ocular surface diseases: keratoconus, pterygium, and dry eye related to graft-versus-host disease	16
Identification of pathogens from native urine samples by MALDI-TOF/TOF tandem mass spectrometry	16
The plasma peptides of sepsis	16
A proteomic repertoire of autoantigens identified from the classic autoantibody clinical test substrate HEp-2 cells	15
Urine proteomics identifies biomarkers for diabetic kidney disease at different stages	15
Rational selection of a biomarker panel targeting unmet clinical needs in kidney injury	14
Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics	14
Label-free proteomic analysis of serum exosomes from paroxysmal atrial fibrillation patients	14
Quantitative proteomics-based analyses performed on pre-eclampsia samples in the 2004–2020 period: a systematic review	14
Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and its emerging mutants	12

Variable blood processing procedures contribute to plasma proteomic variability	12
Secreted protein markers in oral squamous cell carcinoma (OSCC)	12
Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer’s disease biomarkers	10
Identification of TUBB2A by quantitative proteomic analysis as a novel biomarker for the prediction of distant metastatic breast cancer	10
A SISCAPA-based approach for detection of SARS-CoV-2 viral antigens from clinical samples	10
Evaluation of the potential of Pap test fluid and cervical swabs to serve as clinical diagnostic biospecimens for the detection of ovarian cancer by mass spectrometry-based proteomics	10
Development of a novel method for the quantification of tyrosine 39 phosphorylated α- and β-synuclein in human cerebrospinal fluid	10
Human follicular fluid proteome reveals association between overweight status and oocyte maturation abnormality	10
Quantitative analysis of differentially expressed proteins in psoriasis vulgaris using tandem mass tags and parallel reaction monitoring	9
Optimized data-independent acquisition approach for proteomic analysis at single-cell level	9
A nomogram based on glycomic biomarkers in serum and clinicopathological characteristics for evaluating the risk of peritoneal metastasis in gastric cancer	9
Quantitative proteomic analysis of serum-purified exosomes identifies putative pre-eclampsia-associated biomarkers	9
Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation	9
Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML	9
The impact of ultraviolet- and infrared-based laser microdissection technology on phosphoprotein detection in the laser microdissection-reverse phase protein array workflow	9
Combined proteomic/transcriptomic signature of recurrence post-liver transplantation for hepatocellular carcinoma beyond Milan	9
Proteomic approaches for characterizing renal cell carcinoma	8
Quantitative proteomics analysis of lysine 2-hydroxyisobutyrylation in IgA nephropathy	8
Mass spectrometry-based proteomics as an emerging tool in clinical laboratories	8
LC-MS/MS based metabolomics and proteomics reveal candidate biomarkers and molecular mechanism of early IgA nephropathy	7
Proteome profiling of human placenta reveals developmental stage-dependent alterations in protein signature	7
A robust multiplex immunoaffinity mass spectrometry assay (PromarkerD) for clinical prediction of diabetic kidney disease	7
A comprehensive analysis of sialolith proteins and the clinical implications	7
A rigorous evaluation of optimal peptide targets for MS-based clinical diagnostics of Coronavirus Disease 2019 (COVID-19)	7
Subclinical effects of remote ischaemic conditioning in human kidney transplants revealed by quantitative proteomics	7
Global proteome profiling of human livers upon ischemia/reperfusion treatment	6
Analytical validation of a multi-biomarker algorithmic test for prediction of progressive kidney function decline in patients with early-stage kidney disease	6
Data-independent acquisition mass spectrometry in severe rheumatic heart disease (RHD) identifies a proteomic signature showing ongoing inflammation and effectively classifying RHD cases	6
Moving translational mass spectrometry imaging towards transparent and reproducible data analyses: a case study of an urothelial cancer cohort analyzed in the Galaxy framework	6
Discovery of novel glioma serum biomarkers by proximity extension assay	6
Systematic evaluation and optimization of protein extraction parameters in diagnostic FFPE specimens	6
Circulating proteins associated with allergy development in infants—an exploratory analysis	6
Identification of circular RNA BTBD7_hsa_circ_0000563 as a novel biomarker for coronary artery disease and the functional discovery of BTBD7_hsa_circ_0000563 based on peripheral blood mononuclear cell	6
Early changes in tear film protein profiles after femtosecond LASIK surgery	6
Label-free quantitative proteomic analysis of serum exosomes from patients of renal anemia: The Good and the Bad of Roxadustat	5
Integration of transcriptome and proteome profiles in placenta accreta reveals trophoblast over-migration as the underlying pathogenesis	5
Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls	5
Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis	5
O-GlcNAcylation protein disruption by Thiamet G promotes changes on the GBM U87-MG cells secretome molecular signature	5
Novel plasma protein biomarkers from critically ill sepsis patients	5
Serum proteomics unveil characteristic protein diagnostic biomarkers and signaling pathways in patients with esophageal squamous cell carcinoma	5
A novel non-invasive method allowing for discovery of pathologically relevant proteins from small airways	5
Association between cardiovascular disease- and inflammation-related serum biomarkers and poor lung function in elderly	4
Quantitative proteomics reveals the effect of Yigu decoction (YGD) on protein expression in bone tissue	4
Label-free LC–MS/MS proteomics analyses reveal proteomic changes in oxidative stress and the SOD antioxidant strategy in TM cells	4
Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets	4
Mitochondria and cytochrome components released into the plasma of severe COVID-19 and ICU acute respiratory distress syndrome patients	4
Application of SWATH mass spectrometry in the identification of circulating proteins does not predict future weight gain in early psychosis	4
The novel biomarkers for assessing clinical benefits of continuous renal replacement therapy in pediatric sepsis: a pilot study	4
A validated analysis pipeline for mass spectrometry-based vitreous proteomics: new insights into proliferative diabetic retinopathy	4

Determination of temporal reproducibility and variability of cancer biomarkers in serum and EDTA plasma samples using a proximity extension assay	4
Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response	4
Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer	3
Combination of automated sample preparation and micro-flow LC–MS for high-throughput plasma proteomics	3
Orthogonal proteomics methods warrant the development of Duchenne muscular dystrophy biomarkers	3
The use of proteomics for blood biomarker research in premature infants: a scoping review	3
Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry	3
Proteomics-based evaluation of the mechanism underlying vascular injury via DNA interstrand crosslinks, glutathione perturbation, mitogen-activated protein kinase, and Wnt and ErbB signaling pathways	3
Use of MS-GUIDE for identification of protein biomarkers for risk stratification of patients with prostate cancer	3
Comparative proteomic analysis of glomerular proteins in primary and bucillamine-induced membranous nephropathy	3
Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation	3
Development of a rapid and specific MALDI-TOF mass spectrometric assay for SARS-CoV-2 detection	3
Redefining serological diagnostics with immunoaffinity proteomics	3
Transcriptome profiling and proteomic validation reveals targets of the androgen receptor signaling in the BT-474 breast cancer cell line	3
Proteomic analysis of low- and high-grade human colon adenocarcinoma tissues and tissue-derived primary cell lines reveals unique biological functions of tumours and new protein biomarker candidates	2
Comparative proteomics analysis in different stages of urothelial bladder cancer for identification of potential biomarkers: highlighted role for antioxidant activity	2
Proteomic alterations associated with residual disease in neoadjuvant chemotherapy treated ovarian cancer tissues	2
Integrating the serum proteomic and fecal metaproteomic to analyze the impacts of overweight/obesity on IBD: a pilot investigation	2
The rapid detection of procalcitonin in septic serum using immunoaffinity MALDI chips	2
Proteomic alteration of endometrial tissues during secretion in polycystic ovary syndrome may affect endometrial receptivity	2
Comparative analysis of differentially abundant proteins quantified by LC–MS/MS between flash frozen and laser microdissected OCT-embedded breast tumor samples	2
Validation and update of a multivariable prediction model for the identification and management of patients at risk for hepatocellular carcinoma	2
A proteomic profile of the healthy human placenta	2
The associations between red cell distribution width and plasma proteins in a general population	2
Integration of protein context improves protein-based COVID-19 patient stratification	2
Identification of biomarkers of chronic kidney disease among kidney-derived proteins	2
iTRAQ-based quantitative proteomic analysis of thoracic aortas from adult rats born to preeclamptic dams	2
Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling	2
Decreased histidine-rich glycoprotein and increased complement C4-B protein levels in follicular fluid predict the IVF outcomes of recurrent spontaneous abortion	2
Phospho-heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection	2
Robust optimization of SWATH-MS workflow for human blood serum proteome analysis using a quality by design approach	2
Early detection of Ebola virus proteins in peripheral blood mononuclear cells from infected mice	2
Label-free quantitative proteomics reveals aberrant expression levels of LRG, C9, FN, A1AT and AGP1 in the plasma of patients with colorectal cancer	2
Time dependent effect of cold ischemia on the phosphoproteome and protein kinase activity in fresh-frozen colorectal cancer tissue obtained from patients	2
A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumors	2
Chloride intracellular channel 4 participate in the protective effect of Ginkgolide B in MPP+ injured MN9D cells: insight from proteomic analysis	2
Changes of serum IgG glycosylation patterns in rheumatoid arthritis	2
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals	2