OOIR: Observatory of International Research

Papers

(The median citation count of Clinical Proteomics is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Distinct proteomic profiles of clinical isolates show diversity of Pseudomonas aeruginosa colistin-resistance	211
Changes of serum IgG glycosylation patterns in rheumatoid arthritis	92
From blood drops to biomarkers: a scoping review of microsampling in mass spectrometry-based proteomics	48
Recent progress in mass spectrometry-based urinary proteomics	37
A multi-omics study reveals pathway-level insights and predictive biomarkers in pediatric TB	35
Proteome profiling of cutaneous leishmaniasis lesions due to dermotropic Leishmania donovani in Sri Lanka	32
The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies	28
Quantification of putative ovarian cancer serum protein biomarkers using a multiplexed targeted mass spectrometry assay	27
Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue	27
Correction: Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients	24
Comparative mass spectrometry analysis of high and low centrifugation extracellular vesicle (EV) pellets from healthy urine following Tamm-Horsfall protein removal	23
CSF levels of brain-derived proteins correlate with brain ventricular volume in cognitively healthy 70-year-olds	19
Serum proteomics for the identification of biomarkers to flag predilection of COVID19 patients to various organ morbidities	18
Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue	17
Alterations in the pH of pancreatic juice are associated with chymotrypsin C inactivation and lithostathine precipitation in chronic pancreatitis patients: a proteomic approach	17
An ALS assembly modulator signature in peripheral blood mononuclear cells: implications for ALS pathophysiology, therapeutics, and diagnostics	16
Elevated level of multibranched complex glycan reveals an allergic tolerance status	16
Nipple aspirate fluid as a proximal breast liquid biopsy platform: advancing precision risk management in breast cancer	16
Plasma exosome proteomics reveals upregulation of CILP-1 in concave side of paraspinal muscle in adolescent idiopathic scoliosis	15
Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: a cross-sectional case–control study	15
Proteomic profiles screening identified novel exosomal protein biomarkers for diagnosis of lung cancer	14
Discovery of novel glioma serum biomarkers by proximity extension assay	14
Integrated serum proteomics and metabolomics reveal an INR-associated multi-omics signature in hepatocellular carcinoma	14
Quantitative site-specific N-glycosylation analysis reveals IgG glyco-signatures for pancreatic cancer diagnosis	14
Proteomic characteristics and diagnostic potential of exhaled breath particles in patients with COVID-19	14

Targeted proteomics for the detection of androgen receptor variants in preclinical models of castration-resistant prostate cancer	13
Integrating human plasma proteomes with genome-wide association data implicates novel proteins and drug targets for rheumatoid arthritis	13
Neat plasma proteomics: getting the best out of the worst	13
Plasma proteomics in pediatric patients with sepsis– hopes and challenges	13
Longitudinal serum proteomics identifies inflammatory and metabolic pathways in hypertensive nephrosclerosis progression	12
Proteomics study of primary and recurrent adamantinomatous craniopharyngiomas	12
Plasma proteomic profiling reveals distinct protein signatures associated with hepatocellular carcinoma in chronic hepatitis B infection	11
Plasma proteomics of extracellular vesicles identifies key proteins correlating to postoperative atrial fibrillation after coronary artery bypass surgery	11
Plasma proteomic characterization of colorectal cancer patients with FOLFOX chemotherapy by integrated proteomics technology	11
Proteomic insights into the pathophysiology of hypertension-associated albuminuria: Pilot study in a South African cohort	11
Proteomic analyses reveal cystatin c is a promising biomarker for evaluation of systemic lupus erythematosus	11
sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides	10
Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients	10
Quantitative proteomics analysis in small cell carcinoma of cervix reveals novel therapeutic targets	10
The novel biomarkers for assessing clinical benefits of continuous renal replacement therapy in pediatric sepsis: a pilot study	10
Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers	10
Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response	10
Causal effects and mediation pathways of circulating plasma proteins on osteoporosis: a two-sample and two-step Mendelian randomization study	10
Comparative evaluation of analytical methods for CSF proteomics	10
Phospho-heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection	10
Calcium-related genes predict prognosis, immune characteristics, and response to immunotherapy in LUAD patients	9
Characterizing age-related changes in intact mitochondrial proteoforms in murine hearts using quantitative top-down proteomics	9
Clinic-first sepsis recognition in the ICU: a proteomics-guided, parsimonious model with independent validation	9
Integrating multimodal data to predict the progression of hormone-sensitive prostate cancer	9
Development of a rapid and specific MALDI-TOF mass spectrometric assay for SARS-CoV-2 detection	9
Quantitative proteomic analysis of HER2 protein expression in PDAC tumors	9
Proteome profiling of cerebrospinal fluid-derived extracellular vesicles reveals potential biomarkers for drug-resistant epilepsy	9
Decreased histidine-rich glycoprotein and increased complement C4-B protein levels in follicular fluid predict the IVF outcomes of recurrent spontaneous abortion	9
ARTN and CCL23 predicted chemosensitivity in acute myeloid leukemia: an Olink® proteomics approach	9
Novel plasma protein biomarkers from critically ill sepsis patients	9
Recent developments in mass-spectrometry-based targeted proteomics of clinical cancer biomarkers	9
Integrating functional proteomics and next generation sequencing reveals potential therapeutic targets for Taiwanese breast cancer	9
Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex	9
Plasma proteomics in septic shock and alcohol-related pancreatitis: a hyaluronan-centered approach	9
SPOT: spatial proteomics through on-site tissue-protein-labeling	8
Proteomic analysis of plasma exosomes in patients with metastatic colorectal cancer	8
An LC–MS-based designated comparison method with similar performance to the Lp(a) reference measurement procedure to guide molar Lp(a) standardization	8
Closing the gaps in patient management of dyslipidemia: stepping into cardiovascular precision diagnostics with apolipoprotein profiling	8
Proteomic and phosphoproteomic signatures of disease progression in unmutated IGHV chronic lymphocytic leukemia	8
Urinary exosomal RAB11A serves as a novel non-invasive biomarker for diagnosis, treatment response monitoring, and prognosis in small cell lung cancer	8
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers	8
Spatial proteomics to discover aging-associated alterations in the renal tubulointerstitium	8
Human tear film protein sampling using soft contact lenses	8
Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization	8
Identification of adrenocorticotropic hormone–specific therapeutic biomarkers in infantile epileptic spasm syndrome using data-independent acquisition mass spectrometry	8
Evaluation of the relationship between inflammation and typical chest pain in ST-elevation myocardial infarction	8
Absolute quantitation of human wild-type DNAI1 protein in lung tissue using a nanoLC-PRM-MS-based targeted proteomics approach coupled with immunoprecipitation	7
Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry	7
Proteome analysis of CD5-positive diffuse large B cell lymphoma FFPE tissue reveals downregulation of DDX3X, DNAJB1, and B cell receptor signaling pathway proteins including BTK and Immunoglobulins	7
Proteomic analysis identifies subgroups of patients with active systemic lupus erythematosus	7

New mechanisms and biomarkers of lymph node metastasis in cervical cancer: reflections from plasma proteomics	7
Proximity extension assay-based serum proteomic profiling identifies shared protein signatures in hypermobile Ehlers–Danlos syndrome and hypermobility spectrum disorders	7
Medwakh smoking induces alterations in salivary proteins and cytokine expression: a clinical exploratory proteomics investigation	7
Proteomic and glycosylation biomarkers in rheumatoid arthritis: advancing early diagnosis and precision therapy	7
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals	7
Wound fluid proteomics reveal elevated alpha-1 antitrypsin levels are associated with healing of medical device related pressure injury	7
Spatial top-down proteomics for the functional characterization of human kidney	7
Assessing the consistency of mass spectrometry, a clinical-laboratory model, and immunohistochemistry in amyloid subtyping: a Brazilian experience	7
Mass spectrometry-based proteomics as an emerging tool in clinical laboratories	7
Proteomic profiling of extracellular vesicles derived from human serum for the discovery of biomarkers in Avascular necrosis	7
Frontiers in plasma proteome profiling platforms: innovations and applications	7
Functional and quantitative evaluation of the 20S proteasome in serum and intracellular in145 moroccan patients with hematologic malignancies	7
Integrated proteomics and machine learning for identifying candidate serum biomarkers in acute myocardial infarction-complicated cardiogenic shock: a prospective exploratory study	7
Identification of serum proteins associated with response of triple-negative breast cancer to neoadjuvant chemotherapy: preliminary results from the INSTIGO trial	7
Identification of serum N-glycans signatures in three major gastrointestinal cancers by high-throughput N-glycome profiling	7
Combination of automated sample preparation and micro-flow LC–MS for high-throughput plasma proteomics	6
Application of urine proteomics in the diagnosis and treatment effectiveness monitoring of early-stage Mycosis Fungoides	6
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases	6
Redefining serological diagnostics with immunoaffinity proteomics	6
Correction: Unveiling the protein landscape for early detection of colorectal precancerous lesions	6
Correction to: Using phosphoproteomics data to understand cellular signaling: a comprehensive guide to bioinformatics resources	6
Using established biorepositories for emerging research questions: a feasibility study	6
Proteomic signature associated with chronic kidney disease (CKD) progression identified by data-independent acquisition mass spectrometry	6
Exploring the novel duo of Reticulocalbin, and Sideroflexin as future biomarker candidates for Exacerbated Chronic Obstructive Pulmonary Disease	5
Neoplastic cell enrichment of tumor tissues using coring and laser microdissection for proteomic and genomic analyses of pancreatic ductal adenocarcinoma	5
Comparative proteomic analysis of glomerular proteins in IgA nephropathy and IgA vasculitis with nephritis	5
Investigation on the mechanisms of human sperm DNA damage based on the proteomics analysis by SWATH-MS	5
TMT-based proteomic analysis of radiation lung injury in rats	5
The rapid detection of procalcitonin in septic serum using immunoaffinity MALDI chips	5
Identification of SARS-CoV-2 biomarkers in saliva by transcriptomic and proteomics analysis	5
Proteomic profile and predictive markers of outcome in patients with subarachnoid hemorrhage	5
Proteomic profiles in the aqueous following anti-vegf therapy in treatment naïve neovascular age-related macular degeneration	5
Proteomics of human duodenum in pre-diabetes and type 2 diabetes reveals potential novel therapeutic targets for aetiology and therapeutics	5
Identification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicine	5
Advances in mucopolysaccharidosis research: the impact of mass spectrometry-based approaches	5
Unveiling the protein landscape for early detection of colorectal precancerous lesions	5
Tailored therapeutic decision of rheumatoid arthritis using proteomic strategies: how to start and when to stop?	5
Identification of circular RNA BTBD7_hsa_circ_0000563 as a novel biomarker for coronary artery disease and the functional discovery of BTBD7_hsa_circ_0000563 based on peripheral blood mononuclear cell	5
Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy	4
Early detection of breast cancer through the diagnosis of Nipple Aspirate Fluid (NAF)	4
Orthogonal proteomics methods warrant the development of Duchenne muscular dystrophy biomarkers	4
The effect of storage time and temperature on the proteomic analysis of FFPE tissue sections	4
Combined urine proteomics and metabolomics analysis for the diagnosis of pulmonary tuberculosis	4
Protein corona proteomics characterizes low-abundance plasma protein signatures and highlights ferroptosis-associated signals in uremic hemodialysis patients	4
Noninvasive early detection and grading of pneumoconiosis via plasma proteomics and machine learning: PRSS3 as a potential biomarker	4
A proteomic profile of the healthy human placenta	4
Prognostic biomarkers of distant metastasis following curative-intent resection of early-stage rectal cancer	4
Plasma protein signatures altered before and after tuberculosis diagnosis in a population-based cohort	4
Change of histone H3 lysine 14 acetylation stoichiometry in human monocyte derived macrophages as determined by MS-based absolute targeted quantitative proteomic approach: HIV infection and methamphet	4
Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders	4
Differentiation between descending thoracic aortic diseases using machine learning and plasma proteomic signatures	4