OOIR: Observatory of International Research

Papers

(The TQCC of Ocular Surface is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Editorial Board	134
Reassessing interdisciplinary approaches to belantamab mafodotin-induced ocular toxicity: Towards a standardized collaborative model	112
In vivo calcium imaging of corneal sensory nerves with fluorescent stereoscopic microscopy	106
Safety of subconjunctival injection of mesenchymal stromal cells in persistent corneal epithelial disease – A phase 1b clinical trial	76
Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia	76
Monkeypox and ocular implications in humans	70
Endogenous TSG-6 modulates corneal inflammation following chemical injury	69
Atypical microbial keratitis	66
Corrigendum to “New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering” [Ocul. Surf. 30 (October 2023) 204–21	58
Development and validation of a method to generate phenol red thread tests	58
Economic burden of keratitis patients with inpatient care: a nationwide, multicenter registry study	54
Biology and medicine on ocular surface restoration: Advancements and limits of limbal stem cell deficiency treatments	53
Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model	50
Readership awareness series – Paper 10: Open Access Publishing	50
Tear film changes in symptomatic versus asymptomatic video display terminal users following computer challenge test	49
The clinical outcomes of minor salivary gland transplantation for severe dry eye disease secondary to chronic Stevens-Johnson syndrome	46
Mechanistic insights into conjunctivalization in limbal stem cell deficiency using a lineage tracing approach	45
Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders	45
New disposable esthesiometer (KeraSenseⓇ) to improve diagnosis and management of neurotrophic keratitis	44
Diagnostic performance and optimal cut-off values for tear film lipid layer grading and thickness in dry eye disease: An investigator-masked, randomised crossover study	43
A prospective self-controlled study on the alterations of the ocular surface and conjunctival transcriptomic profile associated with prolonged exposure to video display terminals	42
Editorial Board	40
Allogeneic mesenchymal stem cell therapy for dry eye disease in patients with Sjögren's syndrome: A randomized clinical trial	39
Herpes simplex virus, varicella-zoster virus and cytomegalovirus keratitis: Facts for the clinician	37
Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction	35

Chronic inflammation as a proposed risk factor for ocular surface squamous neoplasia	35
Metabolic reprogramming in lacrimal gland GVHD: Stage-specific shifts in acinar cells as drivers of disease progression	35
Epidemiology and risk factors for the development of cicatrizing conjunctivitis in chronic ocular graft-versus-host disease	34
Corneal gene therapy: Structural and mechanistic understanding	31
Effects of age on lacrimal gland bioactive lipids	31
A loss of inter-α-inhibitor Heavy Chain 5 (ITIH5) leads to corneal thinning and increased corneal inflammation following injury and early onset geriatric decline	31
A pilot randomized controlled trial of topical androgen treatment in dry eye	31
Toxicity and efficacy of type I interferons on the ocular surface: in vitro, animal, and clinical studies	31
Cytokine levels and clinical characteristics in the tear fluid of patients with atopic dermatitis and atopic keratoconjunctivitis	30
Limiting plastic waste in dry eye practice for environmental sustainability	30
Investigating the diagnostic utility of non-invasive tear film stability and breakup parameters: A prospective diagnostic accuracy study	29
Profile of tear lipid mediator as a biomarker of inflammation for meibomian gland dysfunction and ocular surface diseases: Standard operating procedures	29
Cyclosporine A 1mg/ml in pediatric blepharokeratoconjunctivitis: Case series of 145 children and young people	29
Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction	28
Interdisciplinary management of belantamab mafodotin-associated ocular toxicity in clinical practice	27
5-Fluorouracil in primary, impending recurrent and recurrent pterygium: Systematic review of the efficacy and safety of a surgical adjuvant and intralesional antimetabolite	27
TFOS Lifestyle Report: Impact of environmental conditions on the ocular surface	26
Topical low-dose heparin in ocular Stevens Johnson Syndrome and associated molecular correlations: A randomized controlled pilot study	26
TFOS Lifestyle: Impact of nutrition on the ocular surface	26
Keratoneuropathy	24
Effect of cosmetics on the measurement of the tear lipid layer thickness by LipiView®	24
Subconjunctival triamcinolone injection for infectious necrotizing scleritis	24
Trustworthy research presentations	24
Readership awareness series – Paper 3: Paper mills	23
Expert consensus on pediatric dry eye: Insights from a European Delphi study	22
Redefining ocular drug delivery	21
Exposure keratopathy in patients undergoing invasive ventilation: Prevalence, severity, and the role of surface lubrication	21
Corneal nerve regeneration is affected by scar location in herpes simplex keratitis: A longitudinal in vivo confocal microscopy study	21
Label-free quantitative imaging of conjunctival goblet cells	21
Host-microbe interactions in cornea	21
1,5-Dicaffeoylquinic acid from Pseudognaphalium affine ameliorates dry eye disease via suppression of inflammation and protection of the ocular surface	21
Rational design and synthesis of lumican stapled peptides for promoting corneal wound healing	20
Investigating conjunctival immune pathways in Sjögren and non-Sjögren disease associated dry eye	20
Ocular pain in ocular graft-versus-host disease patients with neurotrophic keratopathy	20
Insights into the clinical development of regenerative medical products through a comparison of three cell-based products recently approved for limbal stem cell deficiency	20
Intralesional triamcinolone injection as an adjuvant therapy for refractory cicatrizing conjunctivitis	20
Lacrimal gland regeneration: The unmet challenges and promise for dry eye therapy	20
Readership awareness series - Paper 6: How to write a good peer review report?	20
Two models of the structures of the lamellae in human meibum and the tear film lipid layer, TFLL	19
Conjunctival vessel density analysis as a marker of inflammation in dry eye disease	19
Use of a transgenic mouse model for in vivo monitoring of corneal pathologies following Sulfur Mustard Exposure	19
Re: Significant errors in the paper by Ballesteros-Sánchez A, Rocha-de-Lossada C and Sánchez-González J. Efficacy of eyelid warming devices as first-step treatment in meibomian gland dysfunction: A sy	19
A novel artificial intelligence model for diagnosing Acanthamoeba keratitis through confocal microscopy	19
Changes in conjunctival mononuclear phagocytes and suppressive activity of regulatory macrophages in desiccation induced dry eye	19
Visual outcomes of children undergoing penetrating keratoplasty in the US	18
Corneal complications of Sjögren's disease: Insights from a large tertiary ophthalmological care center	18
Report on the 2021 Aniridia North America symposium on PAX6, aniridia, and beyond	18
Corrigendum to “Models for Meibomian gland dysfunction: In vivo and in vitro”, Review article [Ocul. Surf. 32 (2024) 154–165]	18
Transglutaminase-2 is critical for corneal epithelial barrier function via positive regulation of Claudin-1	18
High-resolution high-contrast in vivo phase imaging of corneal nerves and immune cells in mice	18

Evaluation of ocular neuropathic pain	18
Identifying patient-valued outcomes for use in early phase trials of ocular surface disease interventions	18
Optimising the method for visualising mouse meibomian gland using eyelid whole-mount lipid staining	18
Fenofibrate ameliorates ocular surface inflammation in diabetic keratopathy	17
Corneal sensory nerve regulation of tear production through stimulation of transient receptor potential melastatin 8 (TRPM8) channel: A potential new approach for treating dry eye disease	17
Corrigendum to “TFOS lifestyle: Impact of lifestyle challenges on the ocular surface” [Ocul Surf 28 (2023) 262–303]	17
Smad4 deficiency ameliorates the progressive corneal stroma thinning caused by the loss of Tbr1	17
Exploration of imaging and molecular biomarkers for differentiation of neuropathic corneal pain from dry eye syndrome	17
Downregulation of the core circadian gene Nr1d2 in the lacrimal gland contributes to postoperative dry eye disease by impairing lipid metabolism	17
Phenotypic characterization of patients developing chronic dry eye and pain after refractive surgery: A cross-sectional study	17
Autologous serum tears improve corneal nerve density and sensitivity in patients with ocular graft-versus-host disease-associated dry eye disease	17
Readership awareness series – Paper 11: Copyright licensing for scientific publications	17
Deep learning-based classification of fungal and Acanthamoeba keratitis using confocal microscopy	17
Essential roles of sensory nerve in maintenance of cornea-phenotype in mice	16
BMAL1 deficiency provokes dry mouth and eyes by down-regulating ITPR2/3	16
Readership awareness series - Paper 1: Ghost authorship	16
A randomized, vehicle-controlled, Phase 2b study of two concentrations of the TRPM8 receptor agonist AR-15512 in the treatment of dry eye disease (COMET-1)	16
Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas	16
Pipeline: Ocular biostatistics: Proper use of proportions	16
The effect of botulinum neurotoxin A injections on meibomian glands and dry eye	16
Ocular surface squamous neoplasia: Update on genetics, epigenetics and opportunities for targeted therapy	16
Modified technique for sutureless amniotic membrane transplantation in acute Stevens-Johnson syndrome using fibrin sealant	16
Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity	15
Ocular graft-versus-host disease: Experience, incidence, and treatment outcomes at a university-based tertiary care ophthalmology center	15
Pipeline: Therapeutics – Two views of off-label use	15
Hyperosmotic stress-induced NLRP3 inflammasome activation via the mechanosensitive PIEZO1 channel in dry eye corneal epithelium	15
Impact of particulate matter and air pollution on ocular surface disease: A systematic review of preclinical and clinical evidence	15
Association between systemic medication use and severity of dry eye signs and symptoms in the DRy eye assessment and management (DREAM) study	14
Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells	14
Intelligent interferometric analysis of lipid layer thickness for clinical evaluation of dry eye disease	14
In vivo confocal microscopic study of corneal innervation in Sjögren's Syndrome with or without small fiber neuropathy	14
Development and optimization of an ex vivo model of corneal epithelium damage with 1-heptanol: Investigating the influence of donor clinical parameters and MSC-sEV treatment on healing capacity	14
Response to “Methodological considerations regarding 'Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence'”	14
Spontaneous acinar and ductal regrowth after meibomian gland atrophy induced by deletion of FGFR2 in a mouse model	14
IVCM image analysis for limbal stem cell deficiency: quantitative diagnostics of the corneal epithelium post-transplant recovery	14
Pipeline: US FDA efficacy requirements for treatment of ocular surface disease: Drugs vs. medical devices	14
Preservatives and ocular surface disease: A review	13
Readership awareness series – Paper 7: An overview of impact factor and other scientometrics	13
Endoplasmic reticulum stress contributes to the development of ocular graft-vs-host disease in the eyelids and the ocular surface	13
Letter to the editor regarding “TFOS Lifestyle: Impact of the digital environment on the ocular surface”	13
Pard3 promotes corneal epithelial stratification and homeostasis by regulating apical-basal polarity, cytoskeletal organization and tight junction-mediated barrier function	13
Editorial Board	13
Duloxetine enhances PAX6 expression and suppresses innate immune responses in murine LPS-induced corneal inflammation	13
Global burden, risk factors, causative organisms and antibiotic susceptibility patterns in bacterial keratitis	12
Restoration of corneal epithelial barrier function: A possible target for corneal neovascularization	12
A prospective, longitudinal study to assess progression of ocular surface signs, tear cytokines and protein profiles in young adults	12
A novel Schirmer strip-based tear matrix metalloproteinase measurement in dry eye evaluation	12
Delphi panel on neuromodulation as a treatment strategy for dry eye disease: Unlocking the potential of natural tear production	12
Editorial Board	12
Cellular senescence promotes meibomian gland dysfunction in a chronic graft-versus-host disease mouse model	12
Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammation	12
Letter to Editor: Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns	12
Editorial Board	12
Epithelial-mesenchymal transition in the lacrimal gland morphogenesis, damage and repair	12
Adipose-derived mesenchymal stromal cells: A study on safety and efficacy in ocular inflammation	12