OOIR: Observatory of International Research

Papers

(The TQCC of Ocular Surface is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Corrigendum to “New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering” [Ocul. Surf. 30 (October 2023) 204–21	149
Editorial Board	100
Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia	80
Biology and medicine on ocular surface restoration: Advancements and limits of limbal stem cell deficiency treatments	77
Atypical microbial keratitis	63
Effects of Panretinal photocoagulation on the ocular surface and tear film	61
Endogenous TSG-6 modulates corneal inflammation following chemical injury	58
Economic burden of keratitis patients with inpatient care: a nationwide, multicenter registry study	56
Safety of subconjunctival injection of mesenchymal stromal cells in persistent corneal epithelial disease – A phase 1b clinical trial	53
Development and validation of a method to generate phenol red thread tests	51
Monkeypox and ocular implications in humans	47
Dry eye disease and proteomics	44
Epidemiology and risk factors for the development of cicatrizing conjunctivitis in chronic ocular graft-versus-host disease	43
Readership awareness series – Paper 10: Open Access Publishing	43
A prospective self-controlled study on the alterations of the ocular surface and conjunctival transcriptomic profile associated with prolonged exposure to video display terminals	43
Effects of age on lacrimal gland bioactive lipids	42
Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model	42
Tear film changes in symptomatic versus asymptomatic video display terminal users following computer challenge test	40
Impact of digital screen use and lifestyle factors on dry eye disease in the paediatric population	40
Chronic inflammation as a proposed risk factor for ocular surface squamous neoplasia	40
Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction	38
Editorial Board	38
Herpes simplex virus, varicella-zoster virus and cytomegalovirus keratitis: Facts for the clinician	37
A pilot randomized controlled trial of topical androgen treatment in dry eye	36
Allogeneic mesenchymal stem cell therapy for dry eye disease in patients with Sjögren's syndrome: A randomized clinical trial	36

New disposable esthesiometer (KeraSenseⓇ) to improve diagnosis and management of neurotrophic keratitis	34
The clinical outcomes of minor salivary gland transplantation for severe dry eye disease secondary to chronic Stevens-Johnson syndrome	33
Diagnostic performance and optimal cut-off values for tear film lipid layer grading and thickness in dry eye disease: An investigator-masked, randomised crossover study	32
Corneal gene therapy: Structural and mechanistic understanding	31
Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders	31
Interdisciplinary management of belantamab mafodotin-associated ocular toxicity in clinical practice	30
Topical low-dose heparin in ocular Stevens Johnson Syndrome and associated molecular correlations: A randomized controlled pilot study	29
Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction	26
Profile of tear lipid mediator as a biomarker of inflammation for meibomian gland dysfunction and ocular surface diseases: Standard operating procedures	26
Limiting plastic waste in dry eye practice for environmental sustainability	26
Toxicity and efficacy of type I interferons on the ocular surface: in vitro, animal, and clinical studies	26
Reconsidering the pathogenesis of chalazion	25
TFOS Lifestyle: Impact of nutrition on the ocular surface	25
Cyclosporine A 1mg/ml in pediatric blepharokeratoconjunctivitis: Case series of 145 children and young people	25
Investigating the diagnostic utility of non-invasive tear film stability and breakup parameters: A prospective diagnostic accuracy study	24
5-Fluorouracil in primary, impending recurrent and recurrent pterygium: Systematic review of the efficacy and safety of a surgical adjuvant and intralesional antimetabolite	24
A practical framework for telemedicine in dry eye disease	24
TFOS Lifestyle Report: Impact of environmental conditions on the ocular surface	23
Trustworthy research presentations	23
Effect of cosmetics on the measurement of the tear lipid layer thickness by LipiView®	22
Readership awareness series – Paper 3: Paper mills	22
Keratoneuropathy	22
Host-microbe interactions in cornea	22
Insights into the clinical development of regenerative medical products through a comparison of three cell-based products recently approved for limbal stem cell deficiency	21
Corneal nerve regeneration is affected by scar location in herpes simplex keratitis: A longitudinal in vivo confocal microscopy study	21
Expert consensus on pediatric dry eye: Insights from a European Delphi study	21
Subconjunctival triamcinolone injection for infectious necrotizing scleritis	21
1,5-Dicaffeoylquinic acid from Pseudognaphalium affine ameliorates dry eye disease via suppression of inflammation and protection of the ocular surface	21
Redefining ocular drug delivery	20
Rational design and synthesis of lumican stapled peptides for promoting corneal wound healing	20
Exposure keratopathy in patients undergoing invasive ventilation: Prevalence, severity, and the role of surface lubrication	19
Lacrimal gland regeneration: The unmet challenges and promise for dry eye therapy	19
Label-free quantitative imaging of conjunctival goblet cells	19
Readership awareness series - Paper 6: How to write a good peer review report?	18
The evolution of the modified osteo-odonto-keratoprosthesis, its reliability, and long-term visual rehabilitation prognosis: An analytical review	18
Conjunctival vessel density analysis as a marker of inflammation in dry eye disease	18
Re: Significant errors in the paper by Ballesteros-Sánchez A, Rocha-de-Lossada C and Sánchez-González J. Efficacy of eyelid warming devices as first-step treatment in meibomian gland dysfunction: A sy	18
Ocular pain in ocular graft-versus-host disease patients with neurotrophic keratopathy	18
Intralesional triamcinolone injection as an adjuvant therapy for refractory cicatrizing conjunctivitis	18
Evaluating the clinical translational relevance of animal models for limbal stem cell deficiency: A systematic review	18
A novel artificial intelligence model for diagnosing Acanthamoeba keratitis through confocal microscopy	18
Two models of the structures of the lamellae in human meibum and the tear film lipid layer, TFLL	17
Use of a transgenic mouse model for in vivo monitoring of corneal pathologies following Sulfur Mustard Exposure	17
Changes in conjunctival mononuclear phagocytes and suppressive activity of regulatory macrophages in desiccation induced dry eye	17
Drug induced cicatrizing conjunctivitis: A case series with review of etiopathogenesis, diagnosis and management	17
Smad4 deficiency ameliorates the progressive corneal stroma thinning caused by the loss of Tbr1	17
Transglutaminase-2 is critical for corneal epithelial barrier function via positive regulation of Claudin-1	17
Identifying patient-valued outcomes for use in early phase trials of ocular surface disease interventions	17
Corneal sensory nerve regulation of tear production through stimulation of transient receptor potential melastatin 8 (TRPM8) channel: A potential new approach for treating dry eye disease	16
Corrigendum to “Models for Meibomian gland dysfunction: In vivo and in vitro”, Review article [Ocul. Surf. 32 (2024) 154–165]	16

Deep learning-based classification of fungal and Acanthamoeba keratitis using confocal microscopy	16
Non-invasive high-contrast imaging of conjunctival goblet cells for the precision diagnosis of ocular surface diseases	15
Evaluation of ocular neuropathic pain	15
Report on the 2021 Aniridia North America symposium on PAX6, aniridia, and beyond	15
Optimising the method for visualising mouse meibomian gland using eyelid whole-mount lipid staining	15
Autologous serum tears improve corneal nerve density and sensitivity in patients with ocular graft-versus-host disease-associated dry eye disease	15
Fenofibrate ameliorates ocular surface inflammation in diabetic keratopathy	15
Phenotypic characterization of patients developing chronic dry eye and pain after refractive surgery: A cross-sectional study	15
Visual outcomes of children undergoing penetrating keratoplasty in the US	15
Morphological characteristics of Meibomian Glands and their Influence on Dry Eye disease in contact lens wearers	15
High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells	14
Ocular surface squamous neoplasia: Update on genetics, epigenetics and opportunities for targeted therapy	14
Readership awareness series – Paper 11: Copyright licensing for scientific publications	14
Downregulation of the core circadian gene Nr1d2 in the lacrimal gland contributes to postoperative dry eye disease by impairing lipid metabolism	14
Essential roles of sensory nerve in maintenance of cornea-phenotype in mice	14
Ocular graft-versus-host disease: Experience, incidence, and treatment outcomes at a university-based tertiary care ophthalmology center	14
Modified technique for sutureless amniotic membrane transplantation in acute Stevens-Johnson syndrome using fibrin sealant	13
Impact of particulate matter and air pollution on ocular surface disease: A systematic review of preclinical and clinical evidence	13
Exploration of imaging and molecular biomarkers for differentiation of neuropathic corneal pain from dry eye syndrome	13
Hyperosmotic stress-induced NLRP3 inflammasome activation via the mechanosensitive PIEZO1 channel in dry eye corneal epithelium	13
Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity	13
Corrigendum to “TFOS lifestyle: Impact of lifestyle challenges on the ocular surface” [Ocul Surf 28 (2023) 262–303]	13
A randomized, vehicle-controlled, Phase 2b study of two concentrations of the TRPM8 receptor agonist AR-15512 in the treatment of dry eye disease (COMET-1)	13
Pipeline: Ocular biostatistics: Proper use of proportions	13
Readership awareness series - Paper 1: Ghost authorship	13
BMAL1 deficiency provokes dry mouth and eyes by down-regulating ITPR2/3	13
The effect of botulinum neurotoxin A injections on meibomian glands and dry eye	13
Pipeline: Therapeutics – Two views of off-label use	12
Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells	12
Development and optimization of an ex vivo model of corneal epithelium damage with 1-heptanol: Investigating the influence of donor clinical parameters and MSC-sEV treatment on healing capacity	12
Preservatives and ocular surface disease: A review	12
Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas	12
IVCM image analysis for limbal stem cell deficiency: quantitative diagnostics of the corneal epithelium post-transplant recovery	12
Spontaneous acinar and ductal regrowth after meibomian gland atrophy induced by deletion of FGFR2 in a mouse model	12
Cellular senescence promotes meibomian gland dysfunction in a chronic graft-versus-host disease mouse model	12
Response to “Methodological considerations regarding 'Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence'”	12
Pipeline: US FDA efficacy requirements for treatment of ocular surface disease: Drugs vs. medical devices	12
In vivo confocal microscopic study of corneal innervation in Sjögren's Syndrome with or without small fiber neuropathy	12
Association between systemic medication use and severity of dry eye signs and symptoms in the DRy eye assessment and management (DREAM) study	12
Pard3 promotes corneal epithelial stratification and homeostasis by regulating apical-basal polarity, cytoskeletal organization and tight junction-mediated barrier function	11
Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammation	11
Epithelial-mesenchymal transition in the lacrimal gland morphogenesis, damage and repair	11
Duloxetine enhances PAX6 expression and suppresses innate immune responses in murine LPS-induced corneal inflammation	11
Adipose-derived mesenchymal stromal cells: A study on safety and efficacy in ocular inflammation	11
Editorial Board	10
A prospective, longitudinal study to assess progression of ocular surface signs, tear cytokines and protein profiles in young adults	10
Multicenter prospective validation study for international chronic ocular graft-versus-host disease consensus diagnostic criteria	10
Editorial Board	10
Letter to the editor regarding “TFOS Lifestyle: Impact of the digital environment on the ocular surface”	10
Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a pro-differentiation factor that stalls G1-S transition during corneal epithelial cell cycle progression	10
Editorial Board	10
Glycoprotein 340 expression in hyperosmolar stress and infection of corneal epithelial cells	10
Topical steroids to the superior bulbar conjunctiva for the treatment of superior limbic keratoconjunctivitis (SLK)	10
Endoplasmic reticulum stress contributes to the development of ocular graft-vs-host disease in the eyelids and the ocular surface	10
Readership awareness series – Paper 7: An overview of impact factor and other scientometrics	10
Remission of corneal and peripheral neuropathy after bariatric surgery in people with diabetes	10
Impact of botulinum toxin type A on ocular pain with neuropathic features	10
Characterization of the thickness of the Tear Film Lipid Layer in Meibomian Gland Dysfunction using high resolution optical microscopy	10
Restoration of corneal epithelial barrier function: A possible target for corneal neovascularization	10
A novel Schirmer strip-based tear matrix metalloproteinase measurement in dry eye evaluation	10