Ocular Surface

Article	Citations
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells	121
Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands	107
Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface	107
Prevalence of SARS-CoV-2 in human post-mortem ocular tissues	94
Fungal keratitis: A review of clinical presentations, treatment strategies and outcomes	85
Corneal stromal wound healing: Major regulators and therapeutic targets	85
Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea	68
The physical and mental burden of dry eye disease: A large population-based study investigating the relationship with health-related quality of life and its determinants	58
Ocular surface microbiota in patients with aqueous tear-deficient dry eye	53
Use of digital displays and ocular surface alterations: A review	51
Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege	51
Organoids and organ chips in ophthalmology	50
Demographic and lifestyle risk factors of dry eye disease subtypes: A cross-sectional study	50
Pigment epithelium-derived factor (PEDF) plays anti-inflammatory roles in the pathogenesis of dry eye disease	48
The relationship between dry eye and sleep quality	45
Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease	44
TFOS Lifestyle Report: Impact of environmental conditions on the ocular surface	42
The eye as the discrete but defensible portal of coronavirus infection	42
Impact of the COVID-19 pandemic on eye strain and dry eye symptoms	38
The ocular surface immune system through the eyes of aging	38
TFOS Lifestyle: Impact of the digital environment on the ocular surface	38
The epidemiology of infectious keratitis	37
Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation	37
Diagnostic armamentarium of infectious keratitis: A comprehensive review	36
The molecular basis of neurotrophic keratopathy: Diagnostic and therapeutic implications. A review	35

Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions	34
Ocular manifestations of anti-neoplastic immune checkpoint inhibitor-associated Stevens-Johnson syndrome/toxic epidermal necrolysis in cancer patients	33
Developing evidence-based guidance for the treatment of dry eye disease with artificial tear supplements: A six-month multicentre, double-masked randomised controlled trial	33
Correlation of corneal immune cell changes with clinical severity in dry eye disease: An in vivo confocal microscopy study	33
Alterations in corneal nerves in different subtypes of dry eye disease: An in vivo confocal microscopy study	32
Ocular surface disease associated with dupilumab treatment for atopic diseases	31
Supramolecular host-guest hyaluronic acid hydrogels enhance corneal wound healing through dynamic spatiotemporal effects	31
Impact of aging on the pathophysiology of dry eye disease: A systematic review and meta-analysis	31
Relationships between activated dendritic cells and dry eye symptoms and signs	31
Management of corneal complications in vernal keratoconjunctivitis: A review	30
The role of Th17 immunity in chronic ocular surface disorders	30
Small fiber neuropathy in the cornea of Covid-19 patients associated with the generation of ocular surface disease	30
A phase II randomized trial to evaluate the long-term (12-week) efficacy and safety of OC-01 (varenicline solution) nasal spray for dry eye disease: The MYSTIC study	29
Ocular redness – I: Etiology, pathogenesis, and assessment of conjunctival hyperemia	29
The use of in vivo confocal microscopy in fungal keratitis – Progress and challenges	28
Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach	28
Melanocytes as emerging key players in niche regulation of limbal epithelial stem cells	28
TFOS Lifestyle: Impact of lifestyle challenges on the ocular surface	28
Altered ocular surface immune cell profile in patients with dry eye disease	27
Ocular surface diabetic disease: A neurogenic condition?	27
A systematic review of cellular therapies for the treatment of limbal stem cell deficiency affecting one or both eyes	27
Membrane-associated mucins of the human ocular surface in health and disease	26
The vision-related burden of dry eye	26
Artificial intelligence in dry eye disease	25
Conjunctival transcriptome analysis reveals the overexpression of multiple pattern recognition receptors in vernal keratoconjunctivitis	25
Abnormal neovascular and proliferative conjunctival phenotype in limbal stem cell deficiency is associated with altered microRNA and gene expression modulated by PAX6 mutational status in congenital a	25
Epidemiology, economic and humanistic burdens of Ocular Surface Chemical Injury: A narrative review	25
Lid margin keratinization in Stevens-Johnson syndrome: Review of pathophysiology and histopathology	24
The role of nitric oxide in ocular surface physiology and pathophysiology	24
TFOS Lifestyle: Impact of contact lenses on the ocular surface	24
In-situ porcine corneal matrix hydrogel as ocular surface bandage	23
Clinical practice patterns in the management of dry eye disease: A TFOS international survey	23
Automated quantification of meibomian gland dropout in infrared meibography using deep learning	23
TFOS Lifestyle: Impact of societal challenges on the ocular surface	22
The utility of anterior segment optical coherence tomography angiography for the assessment of limbal stem cell deficiency	22
TFOS Lifestyle: Impact of elective medications and procedures on the ocular surface	22
Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes	22
Topical glaucoma medications – Clinical implications for the ocular surface	21
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain	21
Repurposing medications	21
DryEyeRhythm: A reliable and valid smartphone application for the diagnosis assistance of dry eye	21
Matrix metalloproteinase 9 positivity predicts long term decreased tear production	21
Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients	21
TFOS Lifestyle: Impact of nutrition on the ocular surface	21
Relationship between screen time and dry eye symptoms in pediatric population during the COVID-19 pandemic	20
Dysfunction of the limbal epithelial stem cell niche in aniridia-associated keratopathy	20
SARS-CoV-2 and its beta variant of concern infect human conjunctival epithelial cells and induce differential antiviral innate immune response	20
SARS-CoV-2 receptor ACE2 is expressed in human conjunctival tissue, especially in diseased conjunctival tissue	20
Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders	20
TFOS Lifestyle: Impact of cosmetics on the ocular surface	19

Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis – A review	19
Corneal lymphangiogenesis in dry eye disease is regulated by substance P/neurokinin-1 receptor system through controlling expression of vascular endothelial growth factor receptor 3	18
Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction	18
Light cycle phase advance as a model for jet lag reprograms the circadian rhythms of murine extraorbital lacrimal glands	18
Ocular surface disease associated with immune checkpoint inhibitor therapy	18
The link between Keratoconus and posterior segment parameters: An updated, comprehensive review	18
Human meibum and tear film derived (O-acyl)-omega-hydroxy fatty acids in meibomian gland dysfunction	18
Ocular surface disease in thyroid eye disease: A narrative review	17
The relationship between alcohol consumption and dry eye	17
IL-36α/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress	17
The role of meibography in ocular surface diagnostics: A review	17
Safety and efficacy of UV application for superficial infections in humans: A systematic review and meta-analysis	15
Biomarkers of in vivo limbal stem cell function	15
Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population: The JPHC-NEXT study	15
Lacrimal gland regeneration: The unmet challenges and promise for dry eye therapy	15
Latest developments in meibography: A review	15
Meibum sphingolipid composition is altered in individuals with meibomian gland dysfunction-a side by side comparison of Meibum and Tear Sphingolipids	15
The effects of systemic cyclosporine in acute Stevens-Johnson syndrome/toxic epidermal necrolysis on ocular disease	15
Spontaneous face- and eye-touching: Infection risk versus potential microbiome gain	15
Human meibum and tear film derived cholesteryl and wax esters in meibomian gland dysfunction and tear film structure	14
Assessment of response to multimodal management of neurotrophic corneal disease	14
The potential of lipid mediator networks as ocular surface therapeutics and biomarkers	14
Relationship between eyelid margin irregularity and meibomian gland dropout	14
Concurrent ocular pain in patients with neurotrophic keratopathy	14
Neuroanatomy and neurochemistry of rat cornea: Changes with age	14
A multicenter report of the use of plasma rich in growth factors (PRGF) for the treatment of patients with ocular surface diseases in North America	14
Salivary gland transplantation for dry eye disease: Indications, techniques, and outcomes	13
Neuronal-epithelial cell alignment: A determinant of health and disease status of the cornea	13
Randomized trial of topical periocular castor oil treatment for blepharitis	13
Drug induced cicatrizing conjunctivitis: A case series with review of etiopathogenesis, diagnosis and management	13
Regulatory role of miR-146a in corneal epithelial wound healing via its inflammatory targets in human diabetic cornea	13
Readership awareness series – Paper 4: Chatbots and ChatGPT - Ethical considerations in scientific publications	13
A randomized, vehicle-controlled, Phase 2b study of two concentrations of the TRPM8 receptor agonist AR-15512 in the treatment of dry eye disease (COMET-1)	13
The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration	13
Evaluating the clinical translational relevance of animal models for limbal stem cell deficiency: A systematic review	13
Efficacy and outcome of simple limbal epithelial transplantation for limbal stem cell deficiency verified by epithelial phenotypes integrated with clinical evaluation	13
The work-related burden of dry eye	12
Understanding chronic ocular surface pain: An unmet need for targeted drug therapy	12
Dry eye disease and proteomics	12
Toward electron-beam sterilization of a pre-assembled Boston keratoprosthesis	12
MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1/TAB2/NF-κB pathway	12
Medication use and dry eye symptoms: A large, hypothesis-free, population-based study in the Netherlands	12
Eyelid blood vessel and meibomian gland changes in a sclerodermatous chronic GVHD mouse model	12
Herpes simplex virus, varicella-zoster virus and cytomegalovirus keratitis: Facts for the clinician	11
Creation and grading of experimental corneal scars in mice models	11
Mesenchymal stromal cells for corneal transplantation: Literature review and suggestions for successful clinical trials	11
The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease	11
TFOS Lifestyle - Evidence quality report: Advancing the evaluation and synthesis of research evidence	11
Corneal gene therapy: Structural and mechanistic understanding	11
Saturation of cholesteryl esters produced by human meibomian gland epithelial cells after treatment with rosiglitazone	11
Meibomian gland dysfunction is suppressed via selective inhibition of immune responses by topical LFA-1/ICAM antagonism with lifitegrast in the allergic eye disease (AED) model	11
Pain sensitivity and autonomic nervous system parameters as predictors of dry eye symptoms after LASIK	10
TFOS Lifestyle Report Executive Summary: A Lifestyle Epidemic - Ocular Surface Disease	10
Topical use of alcohol in ophthalmology - Diagnostic and therapeutic indications	10
The pattern of the inferocentral whorl region of the corneal subbasal nerve plexus is altered with age	10
Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function	10
Aftermarket effects of cenegermin for neurotrophic keratopathy in pediatric patients	10
Detecting dry eye from ocular surface videos based on deep learning	10
Multicenter prospective validation study for international chronic ocular graft-versus-host disease consensus diagnostic criteria	10
5-Fluorouracil in primary, impending recurrent and recurrent pterygium: Systematic review of the efficacy and safety of a surgical adjuvant and intralesional antimetabolite	10
Impact of glaucoma medications on the ocular surface and how ocular surface disease can influence glaucoma treatment	10
Human precorneal tear film and lipid layer dynamics in meibomian gland dysfunction	10
Normalized ocular surface temperature models for tear film characteristics and dry eye disease evaluation	10
Omega-3 polyunsaturated fatty acids and corneal nerve health: Current evidence and future directions	10
In vivo confocal microscopic study of corneal innervation in Sjögren's Syndrome with or without small fiber neuropathy	10
Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions	10
Face mask use and effects on the ocular surface health: A comprehensive review	9
Bibliometric analysis of the meibomian gland literature	9
Tear metabolomics highlights new potential biomarkers for differentiating between Sjögren's syndrome and other causes of dry eye	9
Chemical and thermal ocular burns in the United States: An IRIS registry analysis	9
The corneal fibroblast: The Dr. Jekyll underappreciated overseer of the responses to stromal injury	9
Prevalence of neurotrophic keratopathy in patients with chronic ocular graft-versus-host disease	9
Updates in diagnostics, treatments, and correlations between oral and ocular manifestations of Sjogren's syndrome	9
Immune signaling in rosacea	9
Surgical management of infectious keratitis	9
Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity	9
Topical 1% 5-fluorouracil eye drops as primary treatment for ocular surface squamous neoplasia: Long-term follow-up study	9
Meibomian gland stem/progenitor cells: The hunt for gland renewal	9
Entry receptor bias in evolutionarily distant HSV-1 clinical strains drives divergent ocular and nervous system pathologies	9
Dry eye disease flares: A rapid evidence assessment	9

Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia	9
Effect of therapeutic UVC on corneal DNA: Safety assessment for potential keratitis treatment	9
The role of sphingolipids in meibomian gland dysfunction and ocular surface inflammation	9
Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease	9
Trends in using mesenchymal stromal/stem cells (MSCs) in treating corneal diseases	8
Density and distribution of dendritiform cells in the peripheral cornea of healthy subjects using in vivo confocal microscopy	8
Ocular redness – II: Progress in development of therapeutics for the management of conjunctival hyperemia	8
Bacterial contamination of intravitreal needles by the ocular surface microbiome	8
Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis	8
Combined therapy of ocular surface disease with plasma rich in growth factors and scleral contact lenses	8
Non-invasive high-contrast imaging of conjunctival goblet cells for the precision diagnosis of ocular surface diseases	8
Synthetic high-density lipoprotein nanoparticles: Good things in small packages	8
Experimental design considerations for studies of human tear proteins	8
Spontaneous acinar and ductal regrowth after meibomian gland atrophy induced by deletion of FGFR2 in a mouse model	8
Human meibomian gland epithelial cell culture models: Current progress, challenges, and future directions	8
High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells	8
Role of transient receptor potential melastatin 8 activity in menthol-induced cold sensitivity and its qualitative perception in dry eye	8
Expression of Acyl-CoA wax-alcohol acyltransferase 2 (AWAT2) by human and rabbit meibomian glands and meibocytes	8
Biological tissues and components, and synthetic substrates for conjunctival cell transplantation	8
Molecular nature of ocular surface barrier function, diseases that affect it, and its relevance for ocular drug delivery	8
Atypical microbial keratitis	7
The evolution of the modified osteo-odonto-keratoprosthesis, its reliability, and long-term visual rehabilitation prognosis: An analytical review	7
The multifaceted aspects of ocular allergies: Phenotypes and endotypes	7
Chronic ocular complications in lamotrigine vs. trimethoprim-sulfamethoxazole induced Stevens-Johnson syndrome/toxic epidermal necrolysis	7
Reconsidering the pathogenesis of chalazion	7
TNF is a critical cytokine in age-related dry eye disease	7
High fat diet induced gut dysbiosis alters corneal epithelial injury response in mice	7
Combinatorial therapy with immunosuppressive, immunomodulatory and tear substitute eyedrops (“Triple Play”) in Recalcitrant Immunological Ocular Surface Diseases	7
Profile of tear lipid mediator as a biomarker of inflammation for meibomian gland dysfunction and ocular surface diseases: Standard operating procedures	7
Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model	7
Safety and feasibility of subconjunctival injection of mesenchymal stem cells for acute severe ocular burns: A single-arm study	7
A systematic review on the effects of ROCK inhibitors on proliferation and/or differentiation in human somatic stem cells: A hypothesis that ROCK inhibitors support corneal endothelial healing via act	7
Disruption of blood-aqueous barrier in dry eye disease	7
Inducing dry eye disease using a custom engineered desiccation system: Impact on the ocular surface including keratin-14-positive limbal epithelial stem cells	7
Corneal nerve changes following treatment with neurotoxic anticancer drugs	7
Monkeypox and ocular implications in humans	7
Review, analysis, and education of antiseptic related ocular injury in the surgical settings	6
Characterization of the thickness of the Tear Film Lipid Layer in Meibomian Gland Dysfunction using high resolution optical microscopy	6
Urgent unmet needs in the care of bacterial keratitis: An evidence-based synthesis	6
Induction of meibocyte differentiation by three-dimensional, matrigel culture of immortalized human meibomian gland epithelial cells to form acinar organoids	6
The impact of contact lenses on meibomian gland morphology	6
Phenotypic characterization of patients developing chronic dry eye and pain after refractive surgery: A cross-sectional study	6
Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture	6
The use of high resolution optical coherence tomography (HR-OCT) in the diagnosis of ocular surface masqueraders	6
Dry eye disease in the young: A narrative review	6
Ultrastructural study of the lacrimal glands in severe dry eye disease following Stevens-Johnson syndrome	6
Imbalanced IL-37/TNF-α/CTSS signaling disrupts corneal epithelial barrier in a dry eye model in vitro	6
Glycosaminoglycans: Roles in wound healing, formation of corneal constructs and synthetic corneas	6
Recent advances in optical coherence tomography for anterior segment imaging in small animals and their clinical implications	6
Long-term outcomes of the MICOF keratoprosthesis surgery	6
Preclinical confirmation of UVC efficacy in treating infectious keratitis	6
In situ metabolic profile and spatial distribution of ocular tissues: New insights into dry eye disease	6
Ocular surface complications of local anticancer drugs for treatment of ocular tumors	6
The antipsychotropic drug Duloxetine rescues PAX6 haploinsufficiency of mutant limbal stem cells through inhibition of the MEK/ERK signaling pathway	6
Small leucine rich proteoglycans: Biology, function and their therapeutic potential in the ocular surface	6
Emerging therapies targeting eosinophil-mediated inflammation in chronic allergic conjunctivitis	6
Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells	5
Inhibition of ceramide de novo synthesis ameliorates meibomian gland dysfunction induced by SCD1 deficiency	5
Proteomic analysis of tears in dry eye disease: A prospective, double-blind multicenter study	5
Novel discovery of a lymphatic bridge connecting Schlemm's canal to limbal and conjunctival lymphatic pathway	5
Limiting plastic waste in dry eye practice for environmental sustainability	5
Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells	5
Dry eye disease and blinking behaviors: A narrative review of methodologies for measuring blink dynamics and inducing blink response	5
Cicatrizing conjunctivitis as an uncommon manifestation of primary Sjögren's syndrome	5
Drug-induced pemphigoid: Clinical presentation, diagnosis, and management of gliptin-associated cicatrizing conjunctivitis	5
Morphological characteristics of Meibomian Glands and their Influence on Dry Eye disease in contact lens wearers	5
Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice	5
Transforming growth factor beta receptor 2 (Tgfbr2) deficiency in keratocytes results in corneal ectasia	5
Contact lens-induced corneal parainflammation involving Ly6G+ cell infiltration requires IL-17A and γδ T cells	5
The miR-183/96/182 cluster is a checkpoint for resident immune cells and shapes the cellular landscape of the cornea	5
The relationship between sedentary behavior and dry eye disease	5
Alleviating experimental allergic eye disease by inhibiting pro-lymphangiogenic VEGFR3 signal	5
The versatile roles of lumican in eye diseases: A review	5
The effect of Rho Kinase inhibition on corneal nerve regeneration in vitro and in vivo	5
Eyeliner tattoos disturb ocular surface homeostasis	5
Insights into the clinical development of regenerative medical products through a comparison of three cell-based products recently approved for limbal stem cell deficiency	5
Readership awareness series – Paper 3: Paper mills	5
Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a pro-differentiation factor that stalls G1-S transition during corneal epithelial cell cycle progression	5
Comparable meibomian gland changes in patients with and without ocular graft-versus-host disease after hematopoietic stem cell transplantation	5
Preliminary experience & rationale of primary allo Simple Limbal Epithelial Transplantation (SLET) following surgical excision of Ocular Surface Tumors	5
Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction: A vehicle-controlled, randomized clinical trial	4
Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration	4
Regulation of innate immune response by miR-628–3p upregulated in the plasma of Stevens-Johnson syndrome patients	4
The effects of a steam warming eye mask on the ocular surface and mental health	4
Tear film changes in symptomatic versus asymptomatic video display terminal users following computer challenge test	4
Therapeutic efficacy of topical blockade of substance P in experimental allergic red eye	4
Human leukocyte antigen class I and II genes associated with dipyrone-related Stevens-Johnson syndrome and severe ocular complications in a Brazilian population	4
Neurotrophic keratopathy: An updated understanding	4
TFOS: Unique challenges and unmet needs for the management of ocular surface diseases throughout the world	4
Perfluorohexyloctane in dry eye disease: A systematic review of its efficacy and safety as a novel therapeutic agent	4
Impact of digital screen use and lifestyle factors on dry eye disease in the paediatric population	4
The genus decision: Potential impact on ophthalmic pharmaceuticals	4
Outcomes of keratolimbal allograft from ABO compatible donors for severe bilateral limbal stem cell deficiency	4
A new option for treatment of severe cicatricial entropion in patients with Stevens-Johnson syndrome	4
Intrastromal versus subconjunctival injection of mesenchymal stem/stromal cells for promoting corneal repair	4