OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Biology & Therapy is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Target c-Myc to treat pancreatic cancer	67
Cancer-associated fibroblasts derived extracellular vesicles promote angiogenesis of colorectal adenocarcinoma cells through miR-135b-5p/FOXO1 axis	38
Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism	33
Therapeutic enhancement of radiation and immunomodulation by gold nanoparticles in triple negative breast cancer	32
HMGA2 promotes breast cancer metastasis by modulating Hippo-YAP signaling pathway	31
Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma	29
CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia–reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation	28
Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo	24
LncRNA AFAP1-AS1 modulates the sensitivity of paclitaxel-resistant prostate cancer cells to paclitaxel via miR-195-5p/FKBP1A axis	24
Crosstalk between PI3K/Akt and Wnt/β-catenin pathways promote colorectal cancer progression regardless of mutational status	23
Pan-cancer analysis of ARID family members as novel biomarkers for immune checkpoint inhibitor therapy	23
The therapeutic potential of exosomal miR-22 for cervical cancer radiotherapy	23
CRC-derived exosomes containing the RNA binding protein HuR promote lung cell proliferation by stabilizing c-Myc mRNA	22
NEDD4L inhibits glycolysis and proliferation of cancer cells in oral squamous cell carcinoma by inducing ENO1 ubiquitination and degradation	22
Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines	22
Interleukin-2, Ipilimumab, and Anti-PD-1: clinical management and the evolving role of immunotherapy for the treatment of patients with metastatic melanoma	22
The role of CD133 in hepatocellular carcinoma	21
Heparan sulfate proteoglycans as targets for cancer therapy: a review	21
The human microbiome and cancer: a diagnostic and therapeutic perspective	20
Ovarian cancer: new strategies and emerging targets for the treatment of patients with advanced disease	19
YY1-inudced activation of lncRNA DUXAP8 promotes proliferation and suppresses apoptosis of triple negative breast cancer cells through upregulating SAPCD2	18
Desmoglein-2 as a prognostic and biomarker in ovarian cancer	18
Feasibility and safety of targeting mitochondria for cancer therapy – preclinical characterization of gamitrinib, a first-in-class, mitochondriaL-targeted small molecule Hsp90 inhibitor	18
Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells	17
NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction	17

Biomarkers for early detection of pancreatic cancer – miRNAs as a potential diagnostic and therapeutic tool?	17
BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes	17
Integration of radiotherapy with anti-PD-1 antibody for the treatment of intrahepatic or hilar cholangiocarcinoma: reflection from four cases	16
LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway	16
The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β	16
Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient -derived xenografts via activation of p53 and inhibition of AKT	15
Lutetium-177-PSMA-617: A Vision of the Future	15
Colorectal cancer chemoprevention: is aspirin still in the game?	15
TP53 mutation detected in circulating exosomal DNA is associated with prognosis of patients with hepatocellular carcinoma	15
LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis	15
CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer	15
circ_C20orf11 enhances DDP resistance by inhibiting miR-527/YWHAZ through the promotion of extracellular vesicle-mediated macrophage M2 polarization in ovarian cancer	14
The role of extracellular DNA (exDNA) in cellular processes	14
Loading of ”cocktail siRNAs” into extracellular vesicles via TAT-DRBD peptide for the treatment of castration-resistant prostate cancer	14
Requirement for containing etoposide in the initial treatment of lymphoma associated hemophagocytic lymphohistiocytosis	14
Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma	13
Selecting the optimal parameters for sonoporation of pancreatic cancer in a pre-clinical model	13
LncRNA FGD5-AS1 accelerates cell proliferation in pancreatic cancer by regulating miR-520a-3p/KIAA1522 axis	13
Targeting long non-coding RNA PVT1/TGF-β/Smad by p53 prevents glioma progression	13
Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling	13
STAT1 mediated long non-coding RNA LINC00504 influences radio-sensitivity of breast cancer via binding to TAF15 and stabilizing CPEB2 expression	13
Partial treatment response to capmatinib in MET-amplified metastatic intrahepatic cholangiocarcinoma: case report & review of literature	13
Targeting CDK9 with selective inhibitors or degraders in tumor therapy: an overview of recent developments	12
Targeting gastrointestinal cancers with chimeric antigen receptor (CAR)-T cell therapy	12
The role of the ubiquitin-proteasome pathway in skin cancer development: 26S proteasome-activated NF-κB signal transduction	12
Current perspectives on exosomes in the diagnosis and treatment of hepatocellular carcinoma (review)	12
CAFs-derived small extracellular vesicles circN4BP2L2 promotes proliferation and metastasis of colorectal cancer via miR-664b-3p/HMGB3 pathway	12
GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma	12
The NF-κB/miR-488/ERBB2 axis modulates pancreatic cancer cell malignancy and tumor growth through cell cycle signaling	12
Carcinoma-associated fibroblasts release microRNA-331-3p containing extracellular vesicles to exacerbate the development of pancreatic cancer via the SCARA5-FAK axis	12
MLLT11-TRIL complex promotes the progression of endometrial cancer through PI3K/AKT/mTOR signaling pathway	12
BMSC-derived exosomal lncRNA PTENP1 suppresses the malignant phenotypes of bladder cancer by upregulating SCARA5 expression	11
Epigenetic modulation of FBW7/Mcl-1 pathway for lung cancer therapy	11
Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo	11
Targeted drug delivery using an aptamer against shared tumor-specific peptide antigen of MAGE-A3	11
Clinicopathological features of PD-L1 protein expression, EBV positivity, and MSI status in patients with advanced gastric and esophagogastric junction adenocarcinoma in Japan	11
MAP17 contributes to non-small cell lung cancer progression via suppressing miR-27a-3p expression and p38 signaling pathway	10
Harnessing the polyamine transport system to treat BRAF inhibitor-resistant melanoma	10
Suppressive function of bone marrow-derived mesenchymal stem cell-derived exosomal microRNA-187 in prostate cancer	10
Long non-coding RNA TDRG1 facilitates cell proliferation, migration and invasion in breast cancer via targeting miR-214-5p/CLIC4 axis	10
Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering †	10
Obesity and metabolic syndrome related macrophage promotes PD-L1 expression in TNBC through IL6/JAK/STAT pathway and can be reversed by telmisartan	10
Ibrutinib’s off-target mechanism: cause for dose optimization	10
Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance	10
Obesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice	9
Clinical and biological determinants of circulating tumor DNA detection and prognostication using a next-generation sequencing panel assay	9
Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma	9
Reprogramming of VEGF-mediated extracellular matrix changes through autocrine signaling	9
The top 100 most-cited papers in long non-coding RNAs: a bibliometric study	9
Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF1	9

NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma	8
Daucosterol combined with umbilical cord mesenchymal stem cell-derived exosomes can alleviate liver damage in liver failure mice by regulating the IL-6/STAT3 signaling pathway	8
Targeted FGFR/VEGFR/PDGFR inhibition with dovitinib enhances the effects of nab-paclitaxel in preclinical gastric cancer models	8
Nivolumab induced hyperprogressive disease in advanced esophageal squamous cell carcinoma	8
Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo	8
Fatty acid binding protein 5 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by degradation of Krüppel-like factor 9 mediated by miR-889-5p via cAMP-response elem	8
Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway	8
Phase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers	8
NF-κB pathway play a role in SCD1 deficiency-induced ceramide de novo synthesis	8
Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway	8
Transcription factor KLF2 enhances the sensitivity of breast cancer cells to cisplatin by suppressing kinase WEE1	8
miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1	8
Maintenance avelumab for metastatic urothelial cancer: a new standard of care	8