Cancer Biology & Therapy

Article	Citations
Target c-Myc to treat pancreatic cancer	46
Exosomal taurine up-regulated 1 promotes angiogenesis and endothelial cell proliferation in cervical cancer	33
Heat shock proteins as biomarkers of lung cancer	30
Cancer-associated fibroblasts derived extracellular vesicles promote angiogenesis of colorectal adenocarcinoma cells through miR-135b-5p/FOXO1 axis	29
Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism	27
Long non-coding RNA (lncRNA) and epithelial-mesenchymal transition (EMT) in colorectal cancer: a systematic review	26
Therapeutic enhancement of radiation and immunomodulation by gold nanoparticles in triple negative breast cancer	26
ST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6	25
Chimeric cytokine receptor enhancing PSMA-CAR-T cell-mediated prostate cancer regression	23
CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia–reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation	23
LncRNA OIP5-AS1 promotes cell proliferation and migration and induces angiogenesis via regulating miR-3163/VEGFA in hepatocellular carcinoma	22
Dysregulated circRNA_100876 contributes to proliferation and metastasis of colorectal cancer by targeting microRNA-516b (miR-516b)	22
LncRNA AFAP1-AS1 modulates the sensitivity of paclitaxel-resistant prostate cancer cells to paclitaxel via miR-195-5p/FKBP1A axis	22
Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo	21
Tumor associated neutrophils promote the metastasis of pancreatic ductal adenocarcinoma	20
Interleukin-2, Ipilimumab, and Anti-PD-1: clinical management and the evolving role of immunotherapy for the treatment of patients with metastatic melanoma	20
Pan-cancer analysis of ARID family members as novel biomarkers for immune checkpoint inhibitor therapy	19
Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma	19
The therapeutic potential of exosomal miR-22 for cervical cancer radiotherapy	19
LINC00641/miR-4262/NRGN axis confines cell proliferation in glioma	18
HMGA2 promotes breast cancer metastasis by modulating Hippo-YAP signaling pathway	18
Chetomin, a Hsp90/HIF1α pathway inhibitor, effectively targets lung cancer stem cells and non-stem cells	18
Cytokines secreted by stromal cells in TNBC microenvironment as potential targets for cancer therapy	17
MiR-185-3p mimic promotes the chemosensitivity of CRC cells via AQP5	17
YY1-inudced activation of lncRNA DUXAP8 promotes proliferation and suppresses apoptosis of triple negative breast cancer cells through upregulating SAPCD2	17

CRC-derived exosomes containing the RNA binding protein HuR promote lung cell proliferation by stabilizing c-Myc mRNA	16
The role of CD133 in hepatocellular carcinoma	16
Heparan sulfate proteoglycans as targets for cancer therapy: a review	16
Phosphorylated STAT3 (Tyr705) as a biomarker of response to pimozide treatment in triple-negative breast cancer	16
Long non-coding RNA SLCO4A1-AS1 drives the progression of non-small-cell lung cancer by modulating miR-223-3p/IKKα/NF-κB signaling	16
NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction	15
Desmoglein-2 as a prognostic and biomarker in ovarian cancer	15
NEDD4L inhibits glycolysis and proliferation of cancer cells in oral squamous cell carcinoma by inducing ENO1 ubiquitination and degradation	15
Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines	14
A novel targeted GPC3/CD3 bispecific antibody for the treatment hepatocellular carcinoma	14
Ovarian cancer: new strategies and emerging targets for the treatment of patients with advanced disease	14
Crosstalk between PI3K/Akt and Wnt/β-catenin pathways promote colorectal cancer progression regardless of mutational status	14
Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient -derived xenografts via activation of p53 and inhibition of AKT	13
MiR-324-5p/PTPRD/CEBPD axis promotes papillary thyroid carcinoma progression via microenvironment alteration	13
FERMT1 promotes gastric cancer progression by activating the NF-κB pathway and predicts poor prognosis	13
Prospects of NSAIDs administration as double-edged agents against endometrial cancer and pathological species of the uterine microbiome	13
Expression and clinical implication of cyclooxygenase-2 and E-cadherin in oral squamous cell carcinomas	13
Biomarkers for early detection of pancreatic cancer – miRNAs as a potential diagnostic and therapeutic tool?	13
The role of extracellular DNA (exDNA) in cellular processes	12
Selecting the optimal parameters for sonoporation of pancreatic cancer in a pre-clinical model	12
Lutetium-177-PSMA-617: A Vision of the Future	12
Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity	12
CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer	12
Frequency of S492R mutations in the epidermal growth factor receptor: analysis of plasma DNA from patients with metastatic colorectal cancer treated with panitumumab or cetuximab monotherapy	12
The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β	12
Integration of radiotherapy with anti-PD-1 antibody for the treatment of intrahepatic or hilar cholangiocarcinoma: reflection from four cases	12
Feasibility and safety of targeting mitochondria for cancer therapy – preclinical characterization of gamitrinib, a first-in-class, mitochondriaL-targeted small molecule Hsp90 inhibitor	12
Rac1 repression reverses chemoresistance by targeting tumor metabolism	11
Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells	11
Loading of ”cocktail siRNAs” into extracellular vesicles via TAT-DRBD peptide for the treatment of castration-resistant prostate cancer	11
Long non-coding RNA ARAP1-AS1 promotes the proliferation and migration in cervical cancer through epigenetic regulation of DUSP5	11
circ_C20orf11 enhances DDP resistance by inhibiting miR-527/YWHAZ through the promotion of extracellular vesicle-mediated macrophage M2 polarization in ovarian cancer	11
Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway	11
FGF13 interaction with SHCBP1 activates AKT-GSK3α/β signaling and promotes the proliferation of A549 cells	11
Current perspectives on exosomes in the diagnosis and treatment of hepatocellular carcinoma (review)	11
TP53 mutation detected in circulating exosomal DNA is associated with prognosis of patients with hepatocellular carcinoma	11
GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma	10
LncRNA WWOX-AS1 sponges miR-20b-5p in hepatocellular carcinoma and represses its progression by upregulating WWOX	10
Targeting gastrointestinal cancers with chimeric antigen receptor (CAR)-T cell therapy	10
Carcinoma-associated fibroblasts release microRNA-331-3p containing extracellular vesicles to exacerbate the development of pancreatic cancer via the SCARA5-FAK axis	10
Long non-coding RNA FALEC promotes colorectal cancer progression via regulating miR-2116-3p-targeted PIWIL1	10
Requirement for containing etoposide in the initial treatment of lymphoma associated hemophagocytic lymphohistiocytosis	10
A novel non-agonist c-Met antibody drug conjugate with superior potency over a c-Met tyrosine kinase inhibitor in c-Met amplified and non-amplified cancers	10
BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes	10
Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling	10
Epigenetic modulation of FBW7/Mcl-1 pathway for lung cancer therapy	10
LncRNA FGD5-AS1 accelerates cell proliferation in pancreatic cancer by regulating miR-520a-3p/KIAA1522 axis	10
miR-221-3p promotes hepatocellular carcinogenesis by downregulating O6-methylguanine-DNA methyltransferase	9
BMSC-derived exosomal lncRNA PTENP1 suppresses the malignant phenotypes of bladder cancer by upregulating SCARA5 expression	9
Apatinib in recurrent anaplastic meningioma: a retrospective case series and systematic literature review	9

MAP17 contributes to non-small cell lung cancer progression via suppressing miR-27a-3p expression and p38 signaling pathway	9
Expression of STAT1 is positively correlated with PD-L1 in human ovarian cancer	9
Clinicopathological features of PD-L1 protein expression, EBV positivity, and MSI status in patients with advanced gastric and esophagogastric junction adenocarcinoma in Japan	9
MLLT11-TRIL complex promotes the progression of endometrial cancer through PI3K/AKT/mTOR signaling pathway	9
The top 100 most-cited papers in long non-coding RNAs: a bibliometric study	9
LINC01128 resisted acute myeloid leukemia through regulating miR-4260/NR3C2	9
STAT1 mediated long non-coding RNA LINC00504 influences radio-sensitivity of breast cancer via binding to TAF15 and stabilizing CPEB2 expression	9
Partial treatment response to capmatinib in MET-amplified metastatic intrahepatic cholangiocarcinoma: case report & review of literature	9
The role of the ubiquitin-proteasome pathway in skin cancer development: 26S proteasome-activated NF-κB signal transduction	9
Obesity and metabolic syndrome related macrophage promotes PD-L1 expression in TNBC through IL6/JAK/STAT pathway and can be reversed by telmisartan	9
Colorectal cancer chemoprevention: is aspirin still in the game?	9
High TKTL1 expression as a sign of poor prognosis in colorectal cancer with synchronous rather than metachronous liver metastases	8
The histone demethylase KDM2B activates FAK and PI3K that control tumor cell motility	8
Targeting long non-coding RNA PVT1/TGF-β/Smad by p53 prevents glioma progression	8
A precise temperature control during hyperthermic intraperitoneal chemotherapy promises an early return of bowel function	8
Targeted drug delivery using an aptamer against shared tumor-specific peptide antigen of MAGE-A3	8
Ibrutinib’s off-target mechanism: cause for dose optimization	8
Ototoxicity in patients with invasive ductal breast cancer who were treated with docetaxel: report of two cases	8
The NF-κB/miR-488/ERBB2 axis modulates pancreatic cancer cell malignancy and tumor growth through cell cycle signaling	8
miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1	8
CAFs-derived small extracellular vesicles circN4BP2L2 promotes proliferation and metastasis of colorectal cancer via miR-664b-3p/HMGB3 pathway	8
Enhanced antitumor effect of alectinib in combination with cyclin-dependent kinase 4/6 inhibitor againstRET-fusion–positive non–small cell lung cancer cells	7
Daucosterol combined with umbilical cord mesenchymal stem cell-derived exosomes can alleviate liver damage in liver failure mice by regulating the IL-6/STAT3 signaling pathway	7
TRIM55 suppresses malignant biological behavior of lung adenocarcinoma cells by increasing protein degradation of Snail1	7
Targeted FGFR/VEGFR/PDGFR inhibition with dovitinib enhances the effects of nab-paclitaxel in preclinical gastric cancer models	7
MMP1 regulated by NEAT1/miR-361-5p axis facilitates the proliferation and migration of cutaneous squamous cell carcinoma via the activation of Wnt pathway	7
Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma	7
Suppressive function of bone marrow-derived mesenchymal stem cell-derived exosomal microRNA-187 in prostate cancer	7
Harnessing the polyamine transport system to treat BRAF inhibitor-resistant melanoma	7
STAT4-mediated down-regulation of miR-3619-5p facilitates stomach adenocarcinoma by modulating TBC1D10B	7
Silencing of LINC00284 inhibits cell proliferation and migration in oral squamous cell carcinoma by the miR-211-3p/MAFG axis and FUS/KAZN axis	7
Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancer	7
Tumor-associated macrophages promote human hepatoma Huh-7 cell migration and invasion through the Gli2/IGF-II/ERK1/2 axis by secreting TGF-β1	7
Plasma KRAS mutations predict the early recurrence after surgical resection of pancreatic cancer	7
LRRC75A-AS1 targets miR-199b-5p/PDCD4 axis to repress multiple myeloma	7
Long non-coding RNA TDRG1 facilitates cell proliferation, migration and invasion in breast cancer via targeting miR-214-5p/CLIC4 axis	7
Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo	7
The use of hedgehog antagonists in cancer therapy: a comparison of clinical outcomes and gene expression analyses	7
Overall tumor genomic instability: an important predictor of recurrence-free survival in patients with localized clear cell renal cell carcinoma	7
Malignant cell-specific pro-tumorigenic role of type I interferon receptor in breast cancers	7
LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway	7
Maintenance avelumab for metastatic urothelial cancer: a new standard of care	6
Transcriptional information underlying the generation of CSCs and the construction of a nine-mRNA signature to improve prognosis prediction in colorectal cancer	6
Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway	6
Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF1	6
Clinical and biological determinants of circulating tumor DNA detection and prognostication using a next-generation sequencing panel assay	6
The human microbiome and cancer: a diagnostic and therapeutic perspective	6
Obesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice	6
Targeting EZH2-mediated methylation of histone 3 inhibits proliferation of pediatric acute monocytic leukemia cells in vitro	6
Transcription factor KLF2 enhances the sensitivity of breast cancer cells to cisplatin by suppressing kinase WEE1	6
Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis	6
Overexpression of family with sequence similarity 134, member B (FAM134B) in colon cancers and its tumor suppressive properties in vitro	6
NF-κB pathway play a role in SCD1 deficiency-induced ceramide de novo synthesis	6
Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib	6
Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA)	6
Phase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers	6
Nivolumab induced hyperprogressive disease in advanced esophageal squamous cell carcinoma	6
MiR-376a-3p increases cell apoptosis in acute myeloid leukemia by targeting MT1X	5
LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis	5
Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway	5
Exosomal epidermal growth factor receptor is involved in HPV-16 E7-induced epithelial-mesenchymal transition of non-small cell lung cancer cells: A driver of signaling in vivo	5
Patient-derived cancer modeling for precision medicine in colorectal cancer: beyond the cancer cell line	5
Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo	5
Clinical implication and usefulness of de novo EGFR T790M mutation in lung adenocarcinoma with EGFR-tyrosine kinase inhibitor sensitizing mutation	5
Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer	5
Identification of potential therapeutic targets in urothelial bladder carcinoma of Chinese population by targeted next-generation sequencing	5
Fatty acid binding protein 5 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by degradation of Krüppel-like factor 9 mediated by miR-889-5p via cAMP-response elem	5
LINC00668 cooperated with HuR dependent upregulation of PKN2 to facilitate gastric cancer metastasis	5
The differences of regulatory networks between papillary and anaplastic thyroid carcinoma: an integrative transcriptomics study	5
Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma	4
Treatment efficacy and safety of drug-eluting beads transarterial chemoembolization versus conventional transarterial chemoembolization in hepatocellular carcinoma patients with arterioportal fistula	4
The impact of drug-eluting bead (vs. conventional) transarterial chemoembolization on hepatic fibrosis in treating intermediate or advanced hepatocellular carcinoma	4
Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering †	4
Evaluation of microRNAs as potential biomarkers in circulating HPV-DNA-positive non-small cell lung cancer patients	4
Biguanide drugs enhance cytotoxic effects of cisplatin by depleting aspartate and NAD+ in sensitive cancer cells	4
Epigenetic drugs induce the potency of classic chemotherapy, suppress post-treatment re-growth of breast cancer, but preserve the wound healing ability of stem cells	4
The therapeutic potential of attenuated diphtheria toxin delivered by an adenovirus vector with survivin promoter on human lung cancer cells	4
Evaluation of the efficacy of the anti-ulcer oral mucosal protective agent RADoralex® in the prevention and treatment of radiation-induced oral mucosal reactions induced during treatment of nasopharyn	4
RETRACTED ARTICLE: DGUOK-AS1 promotes the proliferation cervical cancer through regulating miR-653-5p/EMSY	4
NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC	4

Significant response to apatinib monotherapy in heavily pretreated advanced HER2-positive breast cancer: a case report and literature review	4
Cyclin-dependent kinase 7/9 inhibitor SNS-032 induces apoptosis in diffuse large B-cell lymphoma cells	4
Identification and monitoring of Copy Number Variants (CNV) in monoclonal gammopathy	4
PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer	4
NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma	4
Isolated pineal gland metastasis of acute lymphocytic leukemia: case report	4
STAT3 inhibitor in combination with irradiation significantly inhibits cell viability, cell migration, invasion and tumorsphere growth of human medulloblastoma cells	4
The function and mechanism of the JARID2/CCND1 axis in modulating glioma cell growth and sensitivity to temozolomide (TMZ)	4
Targeting endoplasmic reticulum associated degradation pathway combined with radiotherapy enhances the immunogenicity of esophageal cancer cells	3
Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion	3
The oncogenic role of SOX8 in endometrial carcinoma	3
FGFR2 maintains cancer cell differentiation via AKT signaling in esophageal squamous cell carcinoma	3
Primary squamous cell carcinoma of the breast: report of two cases with HER2 overexpression	3
Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification	3
Drugging the undruggable: activity-based protein profiling offers opportunities for targeting the KLK activome	3
Standardized uptake value (SUVmax) in 18F-FDG PET/CT is correlated with the total number of main oncogenic anomalies in cancer patients	3
Clock in radiation oncology clinics: cost-free modality to alleviate treatment-related toxicity	3
Targeting crosstalk of STAT3 between tumor-associated M2 macrophages and Tregs in colorectal cancer	3
Exploration of p53 plus interferon-beta gene transfer for the sensitization of human colorectal cancer cell lines to cell death	3
HSF1 is involved in immunotherapeutic response through regulating APOJ/STAT3-mediated PD-L1 expression in hepatocellular carcinoma	3
Genomic profiling, prognosis, and potential interventional targets in young and old patients with cholangiocarcinoma	3
Difficult differential diagnosis of bladder pedicled masses about metastasis from non-small cell lung cancer: A case report	3
Epigenetic age acceleration of early stage hepatocellular carcinoma tightly associated with hepatitis B virus load, immunoactivation, and improved survival	3
LncRNA TM4SF19-AS1 exacerbates cell proliferation, migration, invasion, and EMT in head and neck squamous cell carcinoma via enhancing LAMC1 expression	3
Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid	3
Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib	3
Targeting CDK9 with selective inhibitors or degraders in tumor therapy: an overview of recent developments	3
Rituximab-induced acute thrombocytopenia in patients with splenomegaly B Cell lymphoma: an underdiagnosed but severe complication	3