Cancer Biology & Therapy

Article	Citations
Target c-Myc to treat pancreatic cancer	67
Cancer-associated fibroblasts derived extracellular vesicles promote angiogenesis of colorectal adenocarcinoma cells through miR-135b-5p/FOXO1 axis	38
Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism	33
Therapeutic enhancement of radiation and immunomodulation by gold nanoparticles in triple negative breast cancer	32
HMGA2 promotes breast cancer metastasis by modulating Hippo-YAP signaling pathway	31
Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma	29
CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia–reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation	28
LncRNA AFAP1-AS1 modulates the sensitivity of paclitaxel-resistant prostate cancer cells to paclitaxel via miR-195-5p/FKBP1A axis	24
Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo	24
Pan-cancer analysis of ARID family members as novel biomarkers for immune checkpoint inhibitor therapy	23
The therapeutic potential of exosomal miR-22 for cervical cancer radiotherapy	23
Crosstalk between PI3K/Akt and Wnt/β-catenin pathways promote colorectal cancer progression regardless of mutational status	23
Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines	22
Interleukin-2, Ipilimumab, and Anti-PD-1: clinical management and the evolving role of immunotherapy for the treatment of patients with metastatic melanoma	22
CRC-derived exosomes containing the RNA binding protein HuR promote lung cell proliferation by stabilizing c-Myc mRNA	22
NEDD4L inhibits glycolysis and proliferation of cancer cells in oral squamous cell carcinoma by inducing ENO1 ubiquitination and degradation	22
The role of CD133 in hepatocellular carcinoma	21
Heparan sulfate proteoglycans as targets for cancer therapy: a review	21
The human microbiome and cancer: a diagnostic and therapeutic perspective	20
Ovarian cancer: new strategies and emerging targets for the treatment of patients with advanced disease	19
Feasibility and safety of targeting mitochondria for cancer therapy – preclinical characterization of gamitrinib, a first-in-class, mitochondriaL-targeted small molecule Hsp90 inhibitor	18
YY1-inudced activation of lncRNA DUXAP8 promotes proliferation and suppresses apoptosis of triple negative breast cancer cells through upregulating SAPCD2	18
Desmoglein-2 as a prognostic and biomarker in ovarian cancer	18
NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction	17
Biomarkers for early detection of pancreatic cancer – miRNAs as a potential diagnostic and therapeutic tool?	17

BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes	17
Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells	17
LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway	16
The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β	16
Integration of radiotherapy with anti-PD-1 antibody for the treatment of intrahepatic or hilar cholangiocarcinoma: reflection from four cases	16
Colorectal cancer chemoprevention: is aspirin still in the game?	15
TP53 mutation detected in circulating exosomal DNA is associated with prognosis of patients with hepatocellular carcinoma	15
LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis	15
CYP2C8 regulated by GAS5/miR-382-3p exerts anti-cancerous properties in liver cancer	15
Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient -derived xenografts via activation of p53 and inhibition of AKT	15
Lutetium-177-PSMA-617: A Vision of the Future	15
The role of extracellular DNA (exDNA) in cellular processes	14
Loading of ”cocktail siRNAs” into extracellular vesicles via TAT-DRBD peptide for the treatment of castration-resistant prostate cancer	14
Requirement for containing etoposide in the initial treatment of lymphoma associated hemophagocytic lymphohistiocytosis	14
circ_C20orf11 enhances DDP resistance by inhibiting miR-527/YWHAZ through the promotion of extracellular vesicle-mediated macrophage M2 polarization in ovarian cancer	14
Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling	13
STAT1 mediated long non-coding RNA LINC00504 influences radio-sensitivity of breast cancer via binding to TAF15 and stabilizing CPEB2 expression	13
Partial treatment response to capmatinib in MET-amplified metastatic intrahepatic cholangiocarcinoma: case report & review of literature	13
Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma	13
Selecting the optimal parameters for sonoporation of pancreatic cancer in a pre-clinical model	13
LncRNA FGD5-AS1 accelerates cell proliferation in pancreatic cancer by regulating miR-520a-3p/KIAA1522 axis	13
Targeting long non-coding RNA PVT1/TGF-β/Smad by p53 prevents glioma progression	13
GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma	12
The NF-κB/miR-488/ERBB2 axis modulates pancreatic cancer cell malignancy and tumor growth through cell cycle signaling	12
Carcinoma-associated fibroblasts release microRNA-331-3p containing extracellular vesicles to exacerbate the development of pancreatic cancer via the SCARA5-FAK axis	12
MLLT11-TRIL complex promotes the progression of endometrial cancer through PI3K/AKT/mTOR signaling pathway	12
Targeting CDK9 with selective inhibitors or degraders in tumor therapy: an overview of recent developments	12
Targeting gastrointestinal cancers with chimeric antigen receptor (CAR)-T cell therapy	12
The role of the ubiquitin-proteasome pathway in skin cancer development: 26S proteasome-activated NF-κB signal transduction	12
Current perspectives on exosomes in the diagnosis and treatment of hepatocellular carcinoma (review)	12
CAFs-derived small extracellular vesicles circN4BP2L2 promotes proliferation and metastasis of colorectal cancer via miR-664b-3p/HMGB3 pathway	12
Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo	11
Targeted drug delivery using an aptamer against shared tumor-specific peptide antigen of MAGE-A3	11
Clinicopathological features of PD-L1 protein expression, EBV positivity, and MSI status in patients with advanced gastric and esophagogastric junction adenocarcinoma in Japan	11
BMSC-derived exosomal lncRNA PTENP1 suppresses the malignant phenotypes of bladder cancer by upregulating SCARA5 expression	11
Epigenetic modulation of FBW7/Mcl-1 pathway for lung cancer therapy	11
Suppressive function of bone marrow-derived mesenchymal stem cell-derived exosomal microRNA-187 in prostate cancer	10
Long non-coding RNA TDRG1 facilitates cell proliferation, migration and invasion in breast cancer via targeting miR-214-5p/CLIC4 axis	10
Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering †	10
Obesity and metabolic syndrome related macrophage promotes PD-L1 expression in TNBC through IL6/JAK/STAT pathway and can be reversed by telmisartan	10
Ibrutinib’s off-target mechanism: cause for dose optimization	10
Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance	10
MAP17 contributes to non-small cell lung cancer progression via suppressing miR-27a-3p expression and p38 signaling pathway	10
Harnessing the polyamine transport system to treat BRAF inhibitor-resistant melanoma	10
Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma	9
Reprogramming of VEGF-mediated extracellular matrix changes through autocrine signaling	9
The top 100 most-cited papers in long non-coding RNAs: a bibliometric study	9
Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF1	9
Obesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice	9
Clinical and biological determinants of circulating tumor DNA detection and prognostication using a next-generation sequencing panel assay	9

NF-κB pathway play a role in SCD1 deficiency-induced ceramide de novo synthesis	8
Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway	8
Transcription factor KLF2 enhances the sensitivity of breast cancer cells to cisplatin by suppressing kinase WEE1	8
miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1	8
Maintenance avelumab for metastatic urothelial cancer: a new standard of care	8
NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma	8
Daucosterol combined with umbilical cord mesenchymal stem cell-derived exosomes can alleviate liver damage in liver failure mice by regulating the IL-6/STAT3 signaling pathway	8
Targeted FGFR/VEGFR/PDGFR inhibition with dovitinib enhances the effects of nab-paclitaxel in preclinical gastric cancer models	8
Nivolumab induced hyperprogressive disease in advanced esophageal squamous cell carcinoma	8
Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo	8
Fatty acid binding protein 5 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by degradation of Krüppel-like factor 9 mediated by miR-889-5p via cAMP-response elem	8
Zfx-induced upregulation of UBE2J1 facilitates endometrial cancer progression via PI3K/AKT pathway	8
Phase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers	8
Treatment efficacy and safety of drug-eluting beads transarterial chemoembolization versus conventional transarterial chemoembolization in hepatocellular carcinoma patients with arterioportal fistula	7
Plasma KRAS mutations predict the early recurrence after surgical resection of pancreatic cancer	7
Tumor-derived exosomal miR-1247-3p promotes angiogenesis in bladder cancer by targeting FOXO1	7
TRIM55 suppresses malignant biological behavior of lung adenocarcinoma cells by increasing protein degradation of Snail1	7
MiR-376a-3p increases cell apoptosis in acute myeloid leukemia by targeting MT1X	7
Targeting EZH2-mediated methylation of histone 3 inhibits proliferation of pediatric acute monocytic leukemia cells in vitro	7
Red ginseng polysaccharide promotes ferroptosis in gastric cancer cells by inhibiting PI3K/Akt pathway through down-regulation of AQP3	7
MMP1 regulated by NEAT1/miR-361-5p axis facilitates the proliferation and migration of cutaneous squamous cell carcinoma via the activation of Wnt pathway	7
Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification	7
The impact of drug-eluting bead (vs. conventional) transarterial chemoembolization on hepatic fibrosis in treating intermediate or advanced hepatocellular carcinoma	7
LRRC75A-AS1 targets miR-199b-5p/PDCD4 axis to repress multiple myeloma	7
Silencing of LINC00284 inhibits cell proliferation and migration in oral squamous cell carcinoma by the miR-211-3p/MAFG axis and FUS/KAZN axis	7
The therapeutic potential of attenuated diphtheria toxin delivered by an adenovirus vector with survivin promoter on human lung cancer cells	6
Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib	6
Evaluation of microRNAs as potential biomarkers in circulating HPV-DNA-positive non-small cell lung cancer patients	6
A landscape of checkpoint blockade resistance in cancer: underlying mechanisms and current strategies to overcome resistance	6
Exosome-transmitted hsa_circ_0012634 suppresses pancreatic ductal adenocarcinoma progression through regulating miR-147b/HIPK2 axis	6
CX43 down-regulation promotes cell aggressiveness and 5-fluorouracil-resistance by attenuating cell stiffness in colorectal carcinoma	6
Evaluation of the efficacy of the anti-ulcer oral mucosal protective agent RADoralex® in the prevention and treatment of radiation-induced oral mucosal reactions induced during treatment of nasopharyn	6
Targeting crosstalk of STAT3 between tumor-associated M2 macrophages and Tregs in colorectal cancer	6
Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis	6
Epigenetic drugs induce the potency of classic chemotherapy, suppress post-treatment re-growth of breast cancer, but preserve the wound healing ability of stem cells	5
SIRT1 promotes the progression and chemoresistance of colorectal cancer through the p53/miR-101/KPNA3 axis	5
The amino acid transporter SLC7A11 expression in breast cancer	5
LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt s	5
The v8-10 variant isoform of CD44 is selectively expressed in the normal human colonic stem cell niche and frequently is overexpressed in colon carcinomas during tumor development	5
Challenges documenting racial disparities in Merkel cell carcinoma	5
FGFR2 maintains cancer cell differentiation via AKT signaling in esophageal squamous cell carcinoma	5
Knockdown of LINC00511 enhances radiosensitivity of lung adenocarcinoma via regulating miR-497-5p/SMAD3	5
Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2	5
STAT3 inhibitor in combination with irradiation significantly inhibits cell viability, cell migration, invasion and tumorsphere growth of human medulloblastoma cells	5
The function and mechanism of the JARID2/CCND1 axis in modulating glioma cell growth and sensitivity to temozolomide (TMZ)	5
Function of m 5 C RNA methyltransferase NOP2 in high-grade serous ovarian cancer	5
Exosomal epidermal growth factor receptor is involved in HPV-16 E7-induced epithelial-mesenchymal transition of non-small cell lung cancer cells: A driver of signaling in vivo	5
Targeting endoplasmic reticulum associated degradation pathway combined with radiotherapy enhances the immunogenicity of esophageal cancer cells	5
Netrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis	5
Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by activating Wnt signaling	5
The oncogenic role of SOX8 in endometrial carcinoma	5
LINC00668 cooperated with HuR dependent upregulation of PKN2 to facilitate gastric cancer metastasis	5
Higher PD-1/Tim-3 expression on IFN-γ+ T cells is associated with poor prognosis in patients with acute myeloid leukemia	4
Dead or alive? Pitfall of survival analysis with TCGA datasets	4
MiR-18a-5p attenuates HER2-positive breast cancer development by regulating PI3K/AKT pathway	4
MiR-128-1-5p inhibits cell proliferation and induces cell apoptosis via targeting PRKCQ in colorectal cancer	4
Primary squamous cell carcinoma of the breast: report of two cases with HER2 overexpression	4
MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathway	4
PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer	4
JAK-STAT inhibitor as a potential therapeutic opportunity in AML patients resistant to cytarabine and epigenetic therapy	4
NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC	4
Exploration of p53 plus interferon-beta gene transfer for the sensitization of human colorectal cancer cell lines to cell death	4
Immunotherapy resistance in solid tumors: mechanisms and potential solutions	4
Biguanide drugs enhance cytotoxic effects of cisplatin by depleting aspartate and NAD+ in sensitive cancer cells	4
Flotillin-1 enhances radioresistance through reducing radiation-induced DNA damage and promoting immune escape via STING signaling pathway in non-small cell lung cancer	4
Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib	4
Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9	4
KLF4 targets RAB26 and decreases 5-FU resistance through inhibiting autophagy in colon cancer	4
Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion	4
The role of liver cancer stem cells in hepatocellular carcinoma metastasis	4
Cyclin-dependent kinase 7/9 inhibitor SNS-032 induces apoptosis in diffuse large B-cell lymphoma cells	4
Identification and monitoring of Copy Number Variants (CNV) in monoclonal gammopathy	4
HSF1 is involved in immunotherapeutic response through regulating APOJ/STAT3-mediated PD-L1 expression in hepatocellular carcinoma	4
Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression	3
Drugging the undruggable: activity-based protein profiling offers opportunities for targeting the KLK activome	3
A systematic review of datasets that can help elucidate relationships among gene expression, race, and immunohistochemistry-defined subtypes in breast cancer	3
BTF3 promotes proliferation and glycolysis in hepatocellular carcinoma by regulating GLUT1	3
Dysregulation of the circ_0087502/miR-1179/TGFBR2 pathway supports gemcitabine resistance in pancreatic cancer	3
Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis	3
LncRNA TM4SF19-AS1 exacerbates cell proliferation, migration, invasion, and EMT in head and neck squamous cell carcinoma via enhancing LAMC1 expression	3

Targeting mitochondrial tyrosyl-tRNA synthetase YARS2 suppresses colorectal cancer progression	3
Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid	3
VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma	3
Preclinical evaluation of the CDK4/6 inhibitor palbociclib in combination with a PI3K or MEK inhibitor in colorectal cancer	3
TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation	3
Clock in radiation oncology clinics: cost-free modality to alleviate treatment-related toxicity	3
The involvement of MALAT1-ALKBH5 signaling axis into proliferation and metastasis of human papillomavirus-positive cervical cancer	3
Understanding and overcoming resistance to immunotherapy in genitourinary cancers	3
MiR-133b suppresses the proliferation, migration and invasion of lung adenocarcinoma cells by targeting SKA3	3
rAAV9-UPII-TK-EGFP can precisely transduce a suicide gene and inhibit the growth of bladder tumors	3
Apicidin confers promising therapeutic effect on acute myeloid leukemia cells via increasing QPCT expression	3
Genomic profiling, prognosis, and potential interventional targets in young and old patients with cholangiocarcinoma	3
Difficult differential diagnosis of bladder pedicled masses about metastasis from non-small cell lung cancer: A case report	3
Standardized uptake value (SUVmax) in 18F-FDG PET/CT is correlated with the total number of main oncogenic anomalies in cancer patients	3
Integrating DOI in T classification improves the predictive performance of laryngeal cancer staging	3
Influence of genetic polymorphisms in vascular endothelial-related genes on the clinical outcome of axitinib in patients with metastatic renal cell carcinoma	3
A feedback loop between lncRNA MALAT1 and DNMT1 promotes triple-negative breast cancer stemness and tumorigenesis	3
Ras interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells	3
NAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA	3