OOIR: Observatory of International Research

Papers

(The TQCC of Toxicology Mechanisms and Methods is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells	181
An improved method for toxicological profiling of chemical substances	50
Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells	41
Evaluation of the protective effects of curcumin-rich turmeric ( Curcuma longa ) extract against isotretinoin-induced liver damage in rats	37
Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 4	36
Human stromal cell-based protocol to generate astrocytes: a straightforward in vitro predictive strategy in neurotoxicology	34
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment	32
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis	31
Effects of acute carbon monoxide poisoning on liver damage and comparisons of related oxygen therapies in a rat model	27
Assessment of docosahexaenoic acid’s preventive efficacy against unconjugated bilirubin neurotoxicity through MRP1 protein expression	25
Maternal long-term inhalation exposure to perchloroethylene and prenatal teratogenicity: morphometric, hormonal, and histological study	24
Flow-through imaging and automated analysis of oil-exposed early stage Atlantic cod ( Gadus morhua )	22
Chronological activation of the NLRP3 inflammasome/pyroptosis pathway in the progression from metabolic dysfunction-associated fatty liver disease to hepatocellular carcinoma	19
Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236	18
A simple protocol for estimating the acute toxicity of unresolved polar compounds from field-weathered oils	16
Implications of plastic-derived endocrine disruptors on human health	16
Mechanistic paradigms of immunotoxicity, triggered by nanoparticles – a review	16
Establishing a link between the chemical composition and biological activities of Gladiolus italicus Mill. from the Turkish flora utilizing in vitro	15
Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study	15
M3Hep: a multimodal hepatotoxicity prediction model combining mitochondrial toxicity and masking strategy	15
Correction	14
Leveraging AlphaFold models to predict androgenic effects of endocrine-disrupting chemicals through zebrafish androgen receptor analysis	13
Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids	13
Mitochondrial toxic prediction of marine alga toxins using a predictive model based on feature coupling and ensemble learning algorithms	13
The protective effect of co-administration of platelet-rich plasma (PRP) and pentoxifylline (PTX) on cyclophosphamide-induced premature ovarian failure in mature and immature rats	13

Alcohol-induced hormonal and metabolic alterations in plasma and erythrocytes—a gender-based study	13
Toxicological impact of copper nanoparticles on rainbow trout: hematological, biochemical, antioxidant, and histopathological responses with oxidative gene expression	12
Evaluation of cytotoxicity, analysis of metals and cumulative risk assessment in microalgae	12
A novel in vitro assay for rapid screening of embryotoxicity in multiple species	12
Dexamethasone as an anti-cancer or hepatotoxic	12
Time-course cross-species transcriptomics reveals conserved hepatotoxicity pathways induced by repeated administration of cyclosporine A	11
Third party product certification for drinking water health effects	10
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production	10
Bioinformatics analysis of differentially expressed genes related to ischemia and hypoxia in spinal cord injury and construction of miRNA-mRNA or mRNA-transcription factor interaction network	10
Investigation of some metal levels in people using electronic cigarettes and IQOS	10
Decoding the possible mechanism of action of Paeoniflorigenone in combating Aflatoxin B1-induced liver cancer: an investigation using network pharmacology and bioinformatics analysis	10
Mitochondria under fire: toxicological mechanisms of brominated flame retardants	10
The stability of cyanide in human biological samples. A systematic review, meta-analysis and determination of cyanide (GC-QqQ-MS/MS) in an authentic casework 7 years after fatal intoxication	9
Diacerein counteracts amiodarone‑induced hepatotoxicity in rats via targeting TLR4/NF-kB/NLRP3 pathways	9
Potential risk of premature ovarian insufficiency from atrazine exposure: insights into molecular pathways and regulatory implications	9
PM _2.5 -induced DNA oxidative stress in A549 cells and regulating mechanisms by GST DNA methylation and Keap1/Nrf2 pathway	9
Nano and microplastics: unveiling their profound impact on endocrine health	9
Should ebselen be considered for the treatment of mercury intoxication? A minireview	9
Aloe-emodin upregulates DUSP1 to alleviate aristolochic acid-induced renal tubular epithelial cell damage	9
Neurotoxicity mechanisms of pyrethroids studied by network toxicology and molecular docking	9
Effects of pumpkin and fermented whey on fecal microbiota profile against AFB1 and OTA exposure in Wistar rats	8
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model	8
PM2.5 mediates mouse testis Sertoli TM4 cell damage by reducing cellular NAD ⁺	8
Molecular signatures associated with diuron exposure on rat urothelial mitochondria	8
Significant shifts in preclinical and clinical neurotoxicology: a review and commentary	8
Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ	8
Behavioral pharmacology and toxicology of dimethyl sulfoxide in artemia nauplii: vehicle or positive control?	8
Evaluation of acute, subacute, subchronic, reproductive, and genotoxicity of a standardized extract from the bark of Oroxylum indicum	8
Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis	8
Use of TLM derived models to estimate toxicity of weathered MC252 oil based on conventional chemical data and the potential impact of unresolved polar components	8
Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation	7
Development of mass spectrometric methods for determination of desoxycorticosterone pivalate and its esterase product in canine serum	7
An in silico toxicogenomic approach in constructing the aflatoxin B1-mediated regulatory network of hub genes in hepatocellular carcinoma	7
Does the accounting of the local symmetry fragments in quasi-SMILES improve the predictive potential of the QSAR models of toxicity toward tadpoles?	7
5-Hydroxymethylfurfural causes reproductive toxicity in male mice by increasing oxidative stress and apoptosis through the Nrf2/HO-1 signaling pathway	7
Effects of organophosphates on precision-cut kidney slices	7
Application of three-dimensional Raman imaging to determination of the relationship between cellular localization of diesel exhaust particles and the toxicity	7
In silico aquatic toxicity prediction of chemicals toward Daphnia magna and fathead minnow using Monte Carlo approaches	7
Evidence of binding between diethylstilbestrol (DES) and the goldfish ( Carassius auratus ) membrane progesterone receptor α	7
Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers	7
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damag	7
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain	6
The flavonoid hyperoside attenuates the toxic effect of cisplatin on the human ovarian granulosa cells: in vitro model study	6
Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease	6
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague–Dawley rats; action mechanisms and signaling pathways	6
Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells	6
Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats	6
Enhanced kidney damage induced by increasing nonylphenol doses: impact on autophagy-related proteins and proinflammatory cytokines in rats	6
Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice	6
Modulating oxidative stress, apoptosis, and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol	6

Evaluation of novel surfactants for the decontamination of chemical warfare agents	6
Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin	6
Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and Parkin in Pb and β-amyloid peptide induced toxicity	6
Clinical and safety outcomes associated with aristolochic acid exposure: a systematic review and meta-analysis	6
Enhanced anti-cancer efficacy of Sorafenib and Pioglitazone via VEGF inhibition in DMBA-induced breast cancer model	5
Safety assessment of high fructose corn syrup and fructose used as sweeteners in foods	5
Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (Macaca mulatta)	5
Zebrafish larvae locomotion bioassay: application on nanofractionated Naja nigricollis venom	5
Comparison of carcinogenic potential of alternative tobacco products. A systematic review	5
Metformin attenuates PM _2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells	5
Protective effects of polysaccharide extracted from green alga Chaetomorpha linum against zinc and copper-induced testicular toxicity in male mice	5
Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway	5
Deferoxamine ameliorated Al(mal)₃-induced neuronal ferroptosis in adult rats by chelating brain iron to attenuate oxidative damage	5
Development of a standard operating procedure for the DCFH₂-DA acellular assessment of reactive oxygen species produced by nanomaterials	5
Molecular heterogeneity in pediatric sepsis: identification of oxidative stress-related subtypes and diagnostic biomarkers through integrated bioinformatics analysis	5
Sentinel role of military dogs in detecting genotoxic agents in the environment during military operations: a pilot study	5