OOIR: Observatory of International Research

Papers

(The TQCC of Toxicology Mechanisms and Methods is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development	85
Treatment of oxidative stress, apoptosis, and DNA injury with N-acetylcysteine at simulative pesticide toxicity in fish	32
Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis	30
Relevant essential oil components: a minireview on increasing applications and potential toxicity	30
Toxicity, preparation methods and applications of silver nanoparticles: an update	22
Exosomes derived from bone marrow mesenchymal stem cells reverse epithelial-mesenchymal transition potentially via attenuating Wnt/β-catenin signaling to alleviate silica-induced pulmonary fibrosis	22
Phosgene: toxicology, animal models, and medical countermeasures	21
Effects of arsenic exposure on lipid metabolism: a systematic review and meta-analysis	20
Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation	19
Combinative ex vivo studies and in silico models ProTox-II for investigating the toxicity of chemicals used mainly in cosmetic products	19
Deferoxamine ameliorated Al(mal)₃-induced neuronal ferroptosis in adult rats by chelating brain iron to attenuate oxidative damage	18
Curcumin reverses hepatic epithelial mesenchymal transition induced by trichloroethylene by inhibiting IL-6R/STAT3	17
Development of a standard operating procedure for the DCFH₂-DA acellular assessment of reactive oxygen species produced by nanomaterials	17
Aristolochic acid induces mitochondrial apoptosis through oxidative stress in rats, leading to liver damage	16
A comprehensive review of treatments for hydrogen sulfide poisoning: past, present, and future	16
Royal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the nrf-2/NF-κB and bcl-2/bax pathway	16
Dexamethasone as an anti-cancer or hepatotoxic	15
Phosgene oxime: a highly toxic urticant and emerging chemical threat	15
The searching for agents for Alzheimer’s disease treatment via the system of self-consistent models	14
Effects of imidacloprid on viability and increase of reactive oxygen and nitrogen species in HepG2 cell line	14
Genotoxicity evaluation of silica nanoparticles in murine: a systematic review and meta-analysis	12
Targeting macrophage polarization by Nrf2 agonists for treating various xenobiotics-induced toxic responses	12
Development of chlorine-induced lung injury in the anesthetized, spontaneously breathing pig	11
Studying the ophthalmic toxicity potential of developed ketoconazole loaded nanoemulsion in situ gel formulation for ophthalmic administration	11
The role of levosimendan in phosphine-induced cardiotoxicity: evaluation of electrocardiographic, echocardiographic, and biochemical parameters	11

Effects of catechin hydrate in benzo[a]pyrene-induced lung toxicity: roles of oxidative stress, apoptosis, and DNA damage	10
The use of combined high-fructose diet and glyphosate to model rats type 2 diabetes symptomatology	10
Histological and biochemical investigation of the renoprotective effects of metformin in diabetic and prostate cancer model	10
Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity	10
Fluoride induced testicular toxicities in adult Wistar rats	10
Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease	10
Potential protective effect of catechin on doxorubicin-induced cardiotoxicity in adult male albino rats	9
In vivoandin silicoevaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats	9
A systematic review of preclinical studies on the taurine role during diabetic nephropathy: focused on anti-oxidative, anti-inflammation, and anti-apoptotic effects	9
Attenuation of experimentally induced atopic dermatitis in mice by sulforaphane: effect on inflammation and apoptosis	9
Aflatoxin B1 inhibited autophagy flux by inducing lysosomal alkalinization in HepG2 cells	9
Neonatal maternal separation causes decreased numbers of sertoli cell, spermatogenic cells, and sperm in mice	9
Prophylactic effect of probiotics fortified withAloe verapulp nanoemulsion against ethanol-induced gastric ulcer	9
Conjugated linoleic acid protects brain mitochondrial function in acrolein induced male rats	8
Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma	8
Induction of genotoxicity and differential alterations of p53 and inflammatory cytokines expression by acute oral exposure to bulk- or nano-calcium hydroxide particles in mice "Genotoxicity of norm	8
Cardioprotective effects of corilagin on doxorubicin induced cardiotoxicity via P13K/Akt and NF-κB signaling pathways in a rat model	8
Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats	8
Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and Parkin in Pb and β-amyloid peptide induced toxicity	8
The antioxidant study proprieties ofThymus munbyanusaqueous extract and its beneficial effect on 2, 4-Dichlorophenoxyacetic acid -induced hepatic oxidative stress in albino Wistar rats	8
Dexmedetomidine provides protection to neurons against OGD/R-induced oxidative stress and neuronal apoptosis	8
Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling	8
MiR-191 downregulation protects against isoflurane-induced neurotoxicity through targeting BDNF	7
Modification of the hemodynamic and molecular features of phosphine, a potent mitochondrial toxicant in the heart, by cannabidiol	7
Cytotoxicity, oxidative stress, and inflammatory response of smokeless tobacco extracts and cytotoxicity of combustible cigarette whole smoke in a 3D oral organotypic buccal cell model	7
Bidirectional role of reactive oxygen species during inflammasome activation in acrolein-induced human EAhy926 cells pyroptosis	7
In vitro effect of DDE exposure on the regulation of B-TC-6 pancreatic beta cell insulin secretion: a potential role in beta cell dysfunction and type 2 diabetes mellitus	7
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damag	7
N-acetylcysteine ameliorates monocrotophos exposure-induced mitochondrial dysfunctions in rat liver	7
Review of data on chemical content in an aerosol resulting from heating a tobacco or a solution used in e-cigarettes and in the smoke generated from the reference cigarettes	7
Exposure of calcium carbide induces apoptosis in mammalian fibroblast L929 cells	7
The effects of prenatal and lactational bisphenol A and/or di(2-ethylhexyl) phthalate exposure on female reproductive system	6
Neuroprotective potential of trimetazidine against tramadol-induced neurotoxicity: role of PI3K/Akt/mTOR signaling pathways	6
Comparison of the effect of vitamin C and selenium nanoparticles on gentamicin-induced renal impairment in male rats: a biochemical, molecular and histological study	6
Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis	6
Acute and sub-acute toxicity study reveals no dentrimental effect of formononetin in mice upon repeated i.p. dosing	6
Hematotoxic, oxidative and genotoxic damage in rainbow trout (Oncorhynchus mykiss) after exposure to 3-benzoylpyridine	6
Grape seed extract proanthocyanidin antagonizes aristolochic acid I-induced liver injury in rats by activating PI3K-AKT pathway	6
Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells	6
Cardioprotective effect of allyl isothiocyanate in a rat model of doxorubicin acute toxicity	6
Naringenin alleviates hepatic injury in zinc oxide nanoparticles exposed rats: impact on oxido-inflammatory stress and apoptotic cell death	6
Antioxidant and antiproliferative effects of Teucrium polium extract: computational and in vivo study in rats	6
The absence of genotoxicity of a mixture of aloin A and B and a commercial aloe gel beverage	6
Nano-CuO causes cell damage through activation of dose-dependent autophagy and mitochondrial lncCyt b-AS/ND5-AS/ND6-AS in SH-SY5Y cells	6
Schisandrin A alleviates mycophenolic acid-induced intestinal toxicity by regulating cell apoptosis and oxidative damage	6
Sterigmatocystin-induced DNA damage triggers cell-cycle arrestviaMAPK in human neuroblastoma cells	6
Combination of oxytetracycline and quinocetone synergistically induces hepatotoxicity via generation of reactive oxygen species and activation of mitochondrial pathway	6
Comparative outcomes of exposing human liver and kidney cell lines to tungstate and molybdate	6
New Multi-Walled carbon nanotube of industrial interest induce cell death in murine fibroblast cells	6
Crotonaldehyde exposure induces liver dysfunction and mitochondrial energy metabolism disorder in rats	5

Neuroprotective effect of Morin via TrkB/Akt pathway against diabetes mediated oxidative stress and apoptosis in neuronal cells	5
Antihyperlipidemic effect of tyrosol, a phenolic compound in streptozotocin-induced diabetic rats	5
Analysis of cytotoxicity and genotoxicity in a short-term dependent manner induced by a new titanium dioxide nanoparticle in murine fibroblast cells	5
Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-κB/TLR4 signals	5
Safety assessment of a novel water-soluble extract of Boswellia serrata gum resin: acute toxicity, 90-day sub-chronic toxicity, Ames’ bacterial reverse mutation, and in vivo micronucleus	5
Molecular signatures associated with diuron exposure on rat urothelial mitochondria	5
Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids	5
Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin	5
Effects of smokeless tobacco on cell viability, reactive oxygen species, apoptosis, and inflammatory cytokines in human umbilical vein endothelial cells	5
Autophagy up-regulated by MEK/ERK promotes the repair of DNA damage caused by aflatoxin B1	5
Resveratrol may dose-dependently modulate nephrin and OTULIN levels in a doxorubicin-induced nephrotoxicity model	5
Neuroprotective effect of miR-212-5p on isoflurane-induced cognitive dysfunction by inhibiting neuroinflammation	5
Evaluating the protective role of Deglycyrrhizinated licorice root supplement on bleomycin induced pulmonary oxidative damage	5
Evaluation of doxorubicin-induced early multi-organ toxicity in male CD1 mice by biodistribution of¹⁸F-FDG and⁶⁷Ga-citrate. Pilot study	5