OOIR: Observatory of International Research

Papers

(The TQCC of Toxicology Mechanisms and Methods is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells	56
An improved method for toxicological profiling of chemical substances	47
Effects of acute carbon monoxide poisoning on liver damage and comparisons of related oxygen therapies in a rat model	38
Evaluation of the protective effects of curcumin-rich turmeric ( Curcuma longa ) extract against isotretinoin-induced liver damage in rats	31
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment	25
Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 4	23
Human stromal cell-based protocol to generate astrocytes: a straightforward in vitro predictive strategy in neurotoxicology	23
Assessment of docosahexaenoic acid’s preventive efficacy against unconjugated bilirubin neurotoxicity through MRP1 protein expression	21
M3Hep: a multimodal hepatotoxicity prediction model combining mitochondrial toxicity and masking strategy	21
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis	21
Maternal long-term inhalation exposure to perchloroethylene and prenatal teratogenicity: morphometric, hormonal, and histological study	21
Flow-through imaging and automated analysis of oil-exposed early stage Atlantic cod ( Gadus morhua )	19
Mechanistic paradigms of immunotoxicity, triggered by nanoparticles – a review	18
Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236	16
Establishing a link between the chemical composition and biological activities of Gladiolus italicus Mill. from the Turkish flora utilizing in vitro	16
A simple protocol for estimating the acute toxicity of unresolved polar compounds from field-weathered oils	16
Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study	15
Chronological activation of the NLRP3 inflammasome/pyroptosis pathway in the progression from metabolic dysfunction-associated fatty liver disease to hepatocellular carcinoma	15
A microvolume protocol for catalase activity	14
Computational toxicology of N -nitrosamine impurities: from molecular structure to regulatory concern	14
Implications of plastic-derived endocrine disruptors on human health	14
Leveraging AlphaFold models to predict androgenic effects of endocrine-disrupting chemicals through zebrafish androgen receptor analysis	13
Correction	13
Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids	13
Evaluation of cytotoxicity, analysis of metals and cumulative risk assessment in microalgae	12

Mitochondrial toxic prediction of marine alga toxins using a predictive model based on feature coupling and ensemble learning algorithms	12
A novel in vitro assay for rapid screening of embryotoxicity in multiple species	12
Alcohol-induced hormonal and metabolic alterations in plasma and erythrocytes—a gender-based study	11
Dexamethasone as an anti-cancer or hepatotoxic	11
Toxicological impact of copper nanoparticles on rainbow trout: hematological, biochemical, antioxidant, and histopathological responses with oxidative gene expression	11
Bioinformatics analysis of differentially expressed genes related to ischemia and hypoxia in spinal cord injury and construction of miRNA-mRNA or mRNA-transcription factor interaction network	10
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production	10
3-Formylchromone attenuates urethane-induced lung carcinogenesis and enhances gefitinib anti-tumor response via modulation of IL-6/JAK1/STAT3/cyclin D1 signaling	10
Third party product certification for drinking water health effects	10
Diacerein counteracts amiodarone‑induced hepatotoxicity in rats via targeting TLR4/NF-kB/NLRP3 pathways	10
Time-course cross-species transcriptomics reveals conserved hepatotoxicity pathways induced by repeated administration of cyclosporine A	10
Neurotoxicity mechanisms of pyrethroids studied by network toxicology and molecular docking	10
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model	9
E-cigarette aerosols as systemic metabolic disruptors: integrated mitochondrial, circadian, and neurobehavioral mechanisms	9
The stability of cyanide in human biological samples. A systematic review, meta-analysis and determination of cyanide (GC-QqQ-MS/MS) in an authentic casework 7 years after fatal intoxication	9
Potential risk of premature ovarian insufficiency from atrazine exposure: insights into molecular pathways and regulatory implications	9
Investigation of some metal levels in people using electronic cigarettes and IQOS	9
Behavioral pharmacology and toxicology of dimethyl sulfoxide in artemia nauplii: vehicle or positive control?	9
PM _2.5 -induced DNA oxidative stress in A549 cells and regulating mechanisms by GST DNA methylation and Keap1/Nrf2 pathway	9
Decoding the possible mechanism of action of Paeoniflorigenone in combating Aflatoxin B1-induced liver cancer: an investigation using network pharmacology and bioinformatics analysis	9
Should ebselen be considered for the treatment of mercury intoxication? A minireview	9
Significant shifts in preclinical and clinical neurotoxicology: a review and commentary	9
Mitochondria under fire: toxicological mechanisms of brominated flame retardants	9
Aloe-emodin upregulates DUSP1 to alleviate aristolochic acid-induced renal tubular epithelial cell damage	9
Nano and microplastics: unveiling their profound impact on endocrine health	9
Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ	8
Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis	8
Effects of pumpkin and fermented whey on fecal microbiota profile against AFB1 and OTA exposure in Wistar rats	8
Raptors as sentinels: unveiling the environmental and health risks of PFAS contamination	8
Evaluation of acute, subacute, subchronic, reproductive, and genotoxicity of a standardized extract from the bark of Oroxylum indicum	8
PM2.5 mediates mouse testis Sertoli TM4 cell damage by reducing cellular NAD ⁺	7
Comparative screening of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity using spectroscopic and electrometric techniques	7
In silico aquatic toxicity prediction of chemicals toward Daphnia magna and fathead minnow using Monte Carlo approaches	7
5-Hydroxymethylfurfural causes reproductive toxicity in male mice by increasing oxidative stress and apoptosis through the Nrf2/HO-1 signaling pathway	7
Role of connexin32 in zinc oxide nanoparticles induced hepatotoxicity	7
Syringic acid exhibits ameliorative effects against cyclosporine A-induced cardiotoxicity in mice by mitigating oxidative stress, inflammatory response, and apoptotic cell death	7
Comparative stability assessment of synthetic cannabinoids in dry blood spots and blood using UHPLC-MS/MS: implications for forensic applications	7
Use of TLM derived models to estimate toxicity of weathered MC252 oil based on conventional chemical data and the potential impact of unresolved polar components	7
Does the accounting of the local symmetry fragments in quasi-SMILES improve the predictive potential of the QSAR models of toxicity toward tadpoles?	7
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain	6
Nephroprotective role of edaravone against polystyrene nanoplastic-induced endoplasmic reticulum stress in Wistar rats	6
Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats	6
Development of mass spectrometric methods for determination of desoxycorticosterone pivalate and its esterase product in canine serum	6
Modulating oxidative stress, apoptosis, and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol	6
Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers	6
An in silico toxicogenomic approach in constructing the aflatoxin B1-mediated regulatory network of hub genes in hepatocellular carcinoma	6
Enhanced anti-cancer efficacy of Sorafenib and Pioglitazone via VEGF inhibition in DMBA-induced breast cancer model	6
Effects of organophosphates on precision-cut kidney slices	6
Evaluation of novel surfactants for the decontamination of chemical warfare agents	6
Clinical and safety outcomes associated with aristolochic acid exposure: a systematic review and meta-analysis	6

Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells	6
Cisplatin-induced renal toxicity: an integrated view of molecular pathways and emerging therapeutic targets—a comprehensive review	6
Evidence of binding between diethylstilbestrol (DES) and the goldfish ( Carassius auratus ) membrane progesterone receptor α	6
Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice	6
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague–Dawley rats; action mechanisms and signaling pathways	6
Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin	5
Correction	5
Safety and efficacy of a novel phytoceutical formulation CL18100F4 in increasing gut motility and improving stool consistency in animals	5
Ertugliflozin ameliorates thioacetamide-induced renal injury by modulating Nrf2-mediated oxidative stress, TLR4/STAT3 inflammatory signaling, and YAP/TAZ fibrotic pathways	5
Safety assessment of high fructose corn syrup and fructose used as sweeteners in foods	5
Molecular heterogeneity in pediatric sepsis: identification of oxidative stress-related subtypes and diagnostic biomarkers through integrated bioinformatics analysis	5
Enhanced kidney damage induced by increasing nonylphenol doses: impact on autophagy-related proteins and proinflammatory cytokines in rats	5
Metformin attenuates PM _2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells	5
Repurposing of piracetam to alleviate doxorubicin-induced cardiotoxicity in rats: targeting TLR2/MyD88/AP-1/NF-κB and VEGF/eNOS signaling pathways	5
Protective effects of polysaccharide extracted from green alga Chaetomorpha linum against zinc and copper-induced testicular toxicity in male mice	5
Malondialdehyde and nitric oxide levels reveal comparative toxicity of three insecticides in wistar rats	5
Comparison of carcinogenic potential of alternative tobacco products. A systematic review	5
Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (Macaca mulatta)	5
The flavonoid hyperoside attenuates the toxic effect of cisplatin on the human ovarian granulosa cells: in vitro model study	5
Real-time monitoring of microplastic accumulation in fish bodies using transparent goldfish revealed initial attack on the gill	5
Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway	5