OOIR: Observatory of International Research

Papers

(The TQCC of Toxicology Mechanisms and Methods is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development	55
Modeling better in vitro models for the prediction of nanoparticle toxicity: a review	51
The implication of mitochondrial dysfunction and mitochondrial oxidative damage in di (2-ethylhexyl) phthalate induced nephrotoxicity in both in vivo and in vitro models	28
Automated lipid droplet quantification system for phenotypic analysis of adipocytes using CellProfiler	28
Cytotoxicity profiles of multi-walled carbon nanotubes with different physico-chemical properties	27
Treatment of oxidative stress, apoptosis, and DNA injury with N-acetylcysteine at simulative pesticide toxicity in fish	26
Protective effect of metformin against rotenone-induced parkinsonism in mice	22
Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: impact on TGF-β/Smad3 and NF-κB signaling pathways	22
Relevant essential oil components: a minireview on increasing applications and potential toxicity	22
Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis	21
Assesment of hematotoxic, oxidative and genotoxic damage potentials of fipronil in rainbow trout Oncorhynchus mykiss, Walbaum	18
Exosomes derived from bone marrow mesenchymal stem cells reverse epithelial-mesenchymal transition potentially via attenuating Wnt/β-catenin signaling to alleviate silica-induced pulmonary fibrosis	17
Investigation on photo-induced mechanistic activity of GO/TiO₂ hybrid nanocomposite against wound pathogens	17
Neurotoxicity and related mechanisms of flame retardant TCEP exposure in mice	17
Phosgene: toxicology, animal models, and medical countermeasures	17
Toxicity, preparation methods and applications of silver nanoparticles: an update	16
Underlying mechanisms of apoptosis in HepG2 cells induced by polyphyllin I through Fas death and mitochondrial pathways	16
Royal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the nrf-2/NF-κB and bcl-2/bax pathway	15
Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation	15
Deferoxamine ameliorated Al(mal)₃-induced neuronal ferroptosis in adult rats by chelating brain iron to attenuate oxidative damage	15
Effects of arsenic exposure on lipid metabolism: a systematic review and meta-analysis	15
Dexamethasone as an anti-cancer or hepatotoxic	14
The searching for agents for Alzheimer’s disease treatment via the system of self-consistent models	14
Phosgene oxime: a highly toxic urticant and emerging chemical threat	13
Cilostazol protects against cyclophosphamide-induced ovarian toxicity in female rats: role of cAMP and HO-1	13

Chronic exposure to multi-metals on testicular toxicity in rats	13
Effects of imidacloprid on viability and increase of reactive oxygen and nitrogen species in HepG2 cell line	13
A comprehensive review of treatments for hydrogen sulfide poisoning: past, present, and future	13
Development of a standard operating procedure for the DCFH₂-DA acellular assessment of reactive oxygen species produced by nanomaterials	13
Curcumin reverses hepatic epithelial mesenchymal transition induced by trichloroethylene by inhibiting IL-6R/STAT3	12
Aluminum maltolate triggers ferroptosis in neurons: mechanism of action	12
Aristolochic acid induces mitochondrial apoptosis through oxidative stress in rats, leading to liver damage	12
Combinative ex vivo studies and in silico models ProTox-II for investigating the toxicity of chemicals used mainly in cosmetic products	12
Oxidative stress-mediated mitochondrial pathway-dependent apoptosis is induced by silica nanoparticles in H9c2 cardiomyocytes	10
Does low concentration mycotoxin exposure induce toxicity in HepG2 cells through oxidative stress?	10
Histological and biochemical investigation of the renoprotective effects of metformin in diabetic and prostate cancer model	10
Development of chlorine-induced lung injury in the anesthetized, spontaneously breathing pig	10
Targeting macrophage polarization by Nrf2 agonists for treating various xenobiotics-induced toxic responses	9
Effects of catechin hydrate in benzo[a]pyrene-induced lung toxicity: roles of oxidative stress, apoptosis, and DNA damage	9
The role of levosimendan in phosphine-induced cardiotoxicity: evaluation of electrocardiographic, echocardiographic, and biochemical parameters	9
Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity	9
Studying the ophthalmic toxicity potential of developed ketoconazole loaded nanoemulsion in situ gel formulation for ophthalmic administration	9
Attenuation of experimentally induced atopic dermatitis in mice by sulforaphane: effect on inflammation and apoptosis	9
Genotoxicity evaluation of silica nanoparticles in murine: a systematic review and meta-analysis	9
Methyl palmitate reversed estradiol benzoate-induced endometrial hyperplasia in female rats	9
Manganese-induced neurotoxicity and the potential protective effects of lipoic acid and Spirulina platensis	9
Ready to go 3D? A semi-automated protocol for microwell spheroid arrays to increase scalability and throughput of 3D cell culture testing	8
Neonatal maternal separation causes decreased numbers of sertoli cell, spermatogenic cells, and sperm in mice	8
Prophylactic effect of probiotics fortified withAloe verapulp nanoemulsion against ethanol-induced gastric ulcer	8
The antioxidant study proprieties of Thymus munbyanus aqueous extract and its beneficial effect on 2, 4-Dichlorophenoxyacetic acid -induced hepatic oxidative stress in albino Wistar rats	8
Transcriptome alterations and genotoxic influences in zebrafish larvae after exposure to dissolved aluminum and aluminum oxide nanoparticles	8
In vivoandin silicoevaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats	8
The use of combined high-fructose diet and glyphosate to model rats type 2 diabetes symptomatology	8
A systematic review of preclinical studies on the taurine role during diabetic nephropathy: focused on anti-oxidative, anti-inflammation, and anti-apoptotic effects	8
Fluoride induced testicular toxicities in adult Wistar rats	8
Nephro-protective activity of wheatgrass juice against alcohol-induced oxidative damage in rats	8
Conjugated linoleic acid protects brain mitochondrial function in acrolein induced male rats	7
Induction of genotoxicity and differential alterations of p53 and inflammatory cytokines expression by acute oral exposure to bulk- or nano-calcium hydroxide particles in mice "Genotoxicity of norm	7
Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease	7
Dexmedetomidine provides protection to neurons against OGD/R-induced oxidative stress and neuronal apoptosis	7
Predicting the mutagenic potential of chemicals in tobacco products using in silico toxicology tools	7
Aflatoxin B1 inhibited autophagy flux by inducing lysosomal alkalinization in HepG2 cells	7
Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling	7
Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and Parkin in Pb and β-amyloid peptide induced toxicity	7
MiR-191 downregulation protects against isoflurane-induced neurotoxicity through targeting BDNF	6
Cardioprotective effects of corilagin on doxorubicin induced cardiotoxicity via P13K/Akt and NF-κB signaling pathways in a rat model	6
Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats	6
Cytotoxicity, oxidative stress, and inflammatory response of smokeless tobacco extracts and cytotoxicity of combustible cigarette whole smoke in a 3D oral organotypic buccal cell model	6
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damag	6
Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma	6
Bidirectional role of reactive oxygen species during inflammasome activation in acrolein-induced human EAhy926 cells pyroptosis	6
Modification of the hemodynamic and molecular features of phosphine, a potent mitochondrial toxicant in the heart, by cannabidiol	6
‘Ideal correlations’ for the predictive toxicity to Tetrahymena pyriformis	6
Cardioprotective effect of allyl isothiocyanate in a rat model of doxorubicin acute toxicity	6
Review of data on chemical content in an aerosol resulting from heating a tobacco or a solution used in e-cigarettes and in the smoke generated from the reference cigarettes	6

Potential protective effect of catechin on doxorubicin-induced cardiotoxicity in adult male albino rats	6
In vitro effect of DDE exposure on the regulation of B-TC-6 pancreatic beta cell insulin secretion: a potential role in beta cell dysfunction and type 2 diabetes mellitus	6
Nano-CuO causes cell damage through activation of dose-dependent autophagy and mitochondrial lncCyt b-AS/ND5-AS/ND6-AS in SH-SY5Y cells	6