OOIR: Observatory of International Research

Papers

(The TQCC of Toxicology Mechanisms and Methods is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells	169
An improved method for toxicological profiling of chemical substances	46
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis	41
Assessment of docosahexaenoic acid’s preventive efficacy against unconjugated bilirubin neurotoxicity through MRP1 protein expression	34
Evaluation of the protective effects of curcumin-rich turmeric ( Curcuma longa ) extract against isotretinoin-induced liver damage in rats	33
Human stromal cell-based protocol to generate astrocytes: a straightforward in vitro predictive strategy in neurotoxicology	32
Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 4	31
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment	31
Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells	26
Effects of acute carbon monoxide poisoning on liver damage and comparisons of related oxygen therapies in a rat model	24
Maternal long-term inhalation exposure to perchloroethylene and prenatal teratogenicity: morphometric, hormonal, and histological study	23
Flow-through imaging and automated analysis of oil-exposed early stage Atlantic cod ( Gadus morhua )	21
Mechanistic paradigms of immunotoxicity, triggered by nanoparticles – a review	18
Chronological activation of the NLRP3 inflammasome/pyroptosis pathway in the progression from metabolic dysfunction-associated fatty liver disease to hepatocellular carcinoma	18
Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236	16
Implications of plastic-derived endocrine disruptors on human health	15
Establishing a link between the chemical composition and biological activities of Gladiolus italicus Mill. from the Turkish flora utilizing in vitro	15
A simple protocol for estimating the acute toxicity of unresolved polar compounds from field-weathered oils	15
Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study	15
Neuroprotective effect ofBryophyllum pinnatumflavonoids against aluminum chloride-induced neurotoxicity in rats	14
A novel in vitro assay for rapid screening of embryotoxicity in multiple species	14
Correction	14
Dexamethasone as an anti-cancer or hepatotoxic	13
The protective effect of co-administration of platelet-rich plasma (PRP) and pentoxifylline (PTX) on cyclophosphamide-induced premature ovarian failure in mature and immature rats	12
Leveraging AlphaFold models to predict androgenic effects of endocrine-disrupting chemicals through zebrafish androgen receptor analysis	12

Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids	12
Alcohol-induced hormonal and metabolic alterations in plasma and erythrocytes—a gender-based study	12
Toxicological impact of copper nanoparticles on rainbow trout: hematological, biochemical, antioxidant, and histopathological responses with oxidative gene expression	12
Evaluation of cytotoxicity, analysis of metals and cumulative risk assessment in microalgae	12
Mitochondrial toxic prediction of marine alga toxins using a predictive model based on feature coupling and ensemble learning algorithms	12
Time-course cross-species transcriptomics reveals conserved hepatotoxicity pathways induced by repeated administration of cyclosporine A	11
Precision-cut liver slices as a model for assess hepatic cellular response of chitosan–glutathione nanoparticles on cultures treated with zilpaterol and clenbuterol	11
Bioinformatics analysis of differentially expressed genes related to ischemia and hypoxia in spinal cord injury and construction of miRNA-mRNA or mRNA-transcription factor interaction network	11
Third party product certification for drinking water health effects	10
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production	10
Decoding the possible mechanism of action of Paeoniflorigenone in combating Aflatoxin B1-induced liver cancer: an investigation using network pharmacology and bioinformatics analysis	10
Investigation of some metal levels in people using electronic cigarettes and IQOS	9
Potential risk of premature ovarian insufficiency from atrazine exposure: insights into molecular pathways and regulatory implications	9
Nano and microplastics: unveiling their profound impact on endocrine health	9
Diacerein counteracts amiodarone‑induced hepatotoxicity in rats via targeting TLR4/NF-kB/NLRP3 pathways	9
Mitochondria under fire: toxicological mechanisms of brominated flame retardants	9
Aloe-emodin upregulates DUSP1 to alleviate aristolochic acid-induced renal tubular epithelial cell damage	9
Neurotoxicity mechanisms of pyrethroids studied by network toxicology and molecular docking	9
Should ebselen be considered for the treatment of mercury intoxication? A minireview	8
Effects of pumpkin and fermented whey on fecal microbiota profile against AFB1 and OTA exposure in Wistar rats	8
Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis	8
PM _2.5 -induced DNA oxidative stress in A549 cells and regulating mechanisms by GST DNA methylation and Keap1/Nrf2 pathway	8
PM2.5 mediates mouse testis Sertoli TM4 cell damage by reducing cellular NAD ⁺	8
Behavioral pharmacology and toxicology of dimethyl sulfoxide in artemia nauplii: vehicle or positive control?	8
The stability of cyanide in human biological samples. A systematic review, meta-analysis and determination of cyanide (GC-QqQ-MS/MS) in an authentic casework 7 years after fatal intoxication	8
Evaluation of acute, subacute, subchronic, reproductive, and genotoxicity of a standardized extract from the bark of Oroxylum indicum	8
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model	8
Significant shifts in preclinical and clinical neurotoxicology: a review and commentary	8
Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ	7
Does the accounting of the local symmetry fragments in quasi-SMILES improve the predictive potential of the QSAR models of toxicity toward tadpoles?	7
Evidence of binding between diethylstilbestrol (DES) and the goldfish ( Carassius auratus ) membrane progesterone receptor α	7
Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and Parkin in Pb and β-amyloid peptide induced toxicity	7
Use of TLM derived models to estimate toxicity of weathered MC252 oil based on conventional chemical data and the potential impact of unresolved polar components	7
In silico aquatic toxicity prediction of chemicals toward Daphnia magna and fathead minnow using Monte Carlo approaches	7
Development of mass spectrometric methods for determination of desoxycorticosterone pivalate and its esterase product in canine serum	7
Effects of organophosphates on precision-cut kidney slices	7
Molecular signatures associated with diuron exposure on rat urothelial mitochondria	7
5-Hydroxymethylfurfural causes reproductive toxicity in male mice by increasing oxidative stress and apoptosis through the Nrf2/HO-1 signaling pathway	7
Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation	7
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague–Dawley rats; action mechanisms and signaling pathways	7
Modulating oxidative stress, apoptosis, and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol	6
Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells	6
Enhanced kidney damage induced by increasing nonylphenol doses: impact on autophagy-related proteins and proinflammatory cytokines in rats	6
Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers	6
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damag	6
Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats	6
Clinical and safety outcomes associated with aristolochic acid exposure: a systematic review and meta-analysis	6
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain	6
An in silico toxicogenomic approach in constructing the aflatoxin B1-mediated regulatory network of hub genes in hepatocellular carcinoma	6
Application of three-dimensional Raman imaging to determination of the relationship between cellular localization of diesel exhaust particles and the toxicity	6

Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease	6
The flavonoid hyperoside attenuates the toxic effect of cisplatin on the human ovarian granulosa cells: in vitro model study	6
Evaluation of novel surfactants for the decontamination of chemical warfare agents	6
Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice	6
Safety assessment of high fructose corn syrup and fructose used as sweeteners in foods	5
Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (Macaca mulatta)	5
Enhanced anti-cancer efficacy of Sorafenib and Pioglitazone via VEGF inhibition in DMBA-induced breast cancer model	5
Neuroprotective effect of Morin via TrkB/Akt pathway against diabetes mediated oxidative stress and apoptosis in neuronal cells	5
Deferoxamine ameliorated Al(mal)₃-induced neuronal ferroptosis in adult rats by chelating brain iron to attenuate oxidative damage	5
Protective effects of polysaccharide extracted from green alga Chaetomorpha linum against zinc and copper-induced testicular toxicity in male mice	5
Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway	5
Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin	5
Metformin attenuates PM _2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells	5
Integrating network pharmacology and in vitro model to investigate hippocampal neurotoxicity induced by atrazine	5
Molecular heterogeneity in pediatric sepsis: identification of oxidative stress-related subtypes and diagnostic biomarkers through integrated bioinformatics analysis	5
Comparison of carcinogenic potential of alternative tobacco products. A systematic review	5
Sentinel role of military dogs in detecting genotoxic agents in the environment during military operations: a pilot study	5
Development of a standard operating procedure for the DCFH₂-DA acellular assessment of reactive oxygen species produced by nanomaterials	5