OOIR: Observatory of International Research

Papers

(The TQCC of Toxicology Mechanisms and Methods is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells	57
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis	42
Human stromal cell-based protocol to generate astrocytes: a straightforward in vitro predictive strategy in neurotoxicology	34
Effects of acute carbon monoxide poisoning on liver damage and comparisons of related oxygen therapies in a rat model	27
Assessment of docosahexaenoic acid’s preventive efficacy against unconjugated bilirubin neurotoxicity through MRP1 protein expression	24
Evaluation of the protective effects of curcumin-rich turmeric ( Curcuma longa ) extract against isotretinoin-induced liver damage in rats	23
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment	22
Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 4	22
An improved method for toxicological profiling of chemical substances	22
Maternal long-term inhalation exposure to perchloroethylene and prenatal teratogenicity: morphometric, hormonal, and histological study	21
Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study	19
Mechanistic paradigms of immunotoxicity, triggered by nanoparticles – a review	19
Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236	17
A microvolume protocol for catalase activity	16
M3Hep: a multimodal hepatotoxicity prediction model combining mitochondrial toxicity and masking strategy	16
Chronological activation of the NLRP3 inflammasome/pyroptosis pathway in the progression from metabolic dysfunction-associated fatty liver disease to hepatocellular carcinoma	16
A simple protocol for estimating the acute toxicity of unresolved polar compounds from field-weathered oils	15
Establishing a link between the chemical composition and biological activities of Gladiolus italicus Mill. from the Turkish flora utilizing in vitro	15
Flow-through imaging and automated analysis of oil-exposed early stage Atlantic cod ( Gadus morhua )	15
Implications of plastic-derived endocrine disruptors on human health	14
Computational toxicology of N -nitrosamine impurities: from molecular structure to regulatory concern	13
Leveraging AlphaFold models to predict androgenic effects of endocrine-disrupting chemicals through zebrafish androgen receptor analysis	13
Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids	13
A novel in vitro assay for rapid screening of embryotoxicity in multiple species	12
Evaluation of cytotoxicity, analysis of metals and cumulative risk assessment in microalgae	12

Correction	12
Mitochondrial toxic prediction of marine alga toxins using a predictive model based on feature coupling and ensemble learning algorithms	12
Alcohol-induced hormonal and metabolic alterations in plasma and erythrocytes—a gender-based study	11
Combined effects and potential mechanisms of volatile organic compounds on childhood asthma in the US population: an integrated epidemiological and computational toxicology study	11
Third party product certification for drinking water health effects	10
Potential risk of premature ovarian insufficiency from atrazine exposure: insights into molecular pathways and regulatory implications	10
3-Formylchromone attenuates urethane-induced lung carcinogenesis and enhances gefitinib anti-tumor response via modulation of IL-6/JAK1/STAT3/cyclin D1 signaling	10
Time-course cross-species transcriptomics reveals conserved hepatotoxicity pathways induced by repeated administration of cyclosporine A	10
Decoding the possible mechanism of action of Paeoniflorigenone in combating Aflatoxin B1-induced liver cancer: an investigation using network pharmacology and bioinformatics analysis	10
Dexamethasone as an anti-cancer or hepatotoxic	10
Bioinformatics analysis of differentially expressed genes related to ischemia and hypoxia in spinal cord injury and construction of miRNA-mRNA or mRNA-transcription factor interaction network	10
PM _2.5 -induced DNA oxidative stress in A549 cells and regulating mechanisms by GST DNA methylation and Keap1/Nrf2 pathway	10
Mitochondria under fire: toxicological mechanisms of brominated flame retardants	10
Toxicological impact of copper nanoparticles on rainbow trout: hematological, biochemical, antioxidant, and histopathological responses with oxidative gene expression	10
The stability of cyanide in human biological samples. A systematic review, meta-analysis and determination of cyanide (GC-QqQ-MS/MS) in an authentic casework 7 years after fatal intoxication	9
Acute oral toxicity evaluation of microencapsulated semi-purified fibrinolytic proteases using a modified OECD 423–aligned design for biotechnological applications	9
Aloe-emodin upregulates DUSP1 to alleviate aristolochic acid-induced renal tubular epithelial cell damage	9
E-cigarette aerosols as systemic metabolic disruptors: integrated mitochondrial, circadian, and neurobehavioral mechanisms	9
Investigation of some metal levels in people using electronic cigarettes and IQOS	9
Neurotoxicity mechanisms of pyrethroids studied by network toxicology and molecular docking	9
Diacerein counteracts amiodarone‑induced hepatotoxicity in rats via targeting TLR4/NF-kB/NLRP3 pathways	9
Should ebselen be considered for the treatment of mercury intoxication? A minireview	9
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production	9
Nano and microplastics: unveiling their profound impact on endocrine health	9
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model	8
Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ	8
Effects of pumpkin and fermented whey on fecal microbiota profile against AFB1 and OTA exposure in Wistar rats	8
Behavioral pharmacology and toxicology of dimethyl sulfoxide in artemia nauplii: vehicle or positive control?	8
Evaluation of acute, subacute, subchronic, reproductive, and genotoxicity of a standardized extract from the bark of Oroxylum indicum	8
Raptors as sentinels: unveiling the environmental and health risks of PFAS contamination	8
Significant shifts in preclinical and clinical neurotoxicology: a review and commentary	8
5-Hydroxymethylfurfural causes reproductive toxicity in male mice by increasing oxidative stress and apoptosis through the Nrf2/HO-1 signaling pathway	8
PM2.5 mediates mouse testis Sertoli TM4 cell damage by reducing cellular NAD ⁺	8
Comparative stability assessment of synthetic cannabinoids in dry blood spots and blood using UHPLC-MS/MS: implications for forensic applications	7
Use of TLM derived models to estimate toxicity of weathered MC252 oil based on conventional chemical data and the potential impact of unresolved polar components	7
Comparative screening of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity using spectroscopic and electrometric techniques	7
In silico aquatic toxicity prediction of chemicals toward Daphnia magna and fathead minnow using Monte Carlo approaches	7
Role of connexin32 in zinc oxide nanoparticles induced hepatotoxicity	7
Syringic acid exhibits ameliorative effects against cyclosporine A-induced cardiotoxicity in mice by mitigating oxidative stress, inflammatory response, and apoptotic cell death	7
Does the accounting of the local symmetry fragments in quasi-SMILES improve the predictive potential of the QSAR models of toxicity toward tadpoles?	7
An in silico toxicogenomic approach in constructing the aflatoxin B1-mediated regulatory network of hub genes in hepatocellular carcinoma	6
Effects of organophosphates on precision-cut kidney slices	6
Development of mass spectrometric methods for determination of desoxycorticosterone pivalate and its esterase product in canine serum	6
Tobacco-specific nitrosamine ‘4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)’: toxicological mechanisms, carcinogenicity, and chemopreventive approaches	6
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain	6
Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells	6
Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers	6
Evaluation of novel surfactants for the decontamination of chemical warfare agents	6
Nephroprotective role of edaravone against polystyrene nanoplastic-induced endoplasmic reticulum stress in Wistar rats	6
Evidence of binding between diethylstilbestrol (DES) and the goldfish ( Carassius auratus ) membrane progesterone receptor α	6

Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice	6
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague–Dawley rats; action mechanisms and signaling pathways	6
Modulating oxidative stress, apoptosis, and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol	6
Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats	5
Malondialdehyde and nitric oxide levels reveal comparative toxicity of three insecticides in wistar rats	5
Enhanced kidney damage induced by increasing nonylphenol doses: impact on autophagy-related proteins and proinflammatory cytokines in rats	5
Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (Macaca mulatta)	5
Safety and efficacy of a novel phytoceutical formulation CL18100F4 in increasing gut motility and improving stool consistency in animals	5
Clinical and safety outcomes associated with aristolochic acid exposure: a systematic review and meta-analysis	5
Enhanced anti-cancer efficacy of Sorafenib and Pioglitazone via VEGF inhibition in DMBA-induced breast cancer model	5
The flavonoid hyperoside attenuates the toxic effect of cisplatin on the human ovarian granulosa cells: in vitro model study	5
Metformin attenuates PM _2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells	5
Protective effects of polysaccharide extracted from green alga Chaetomorpha linum against zinc and copper-induced testicular toxicity in male mice	5
Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway	5
Cisplatin-induced renal toxicity: an integrated view of molecular pathways and emerging therapeutic targets—a comprehensive review	5
Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin	5
Correction	5
Molecular heterogeneity in pediatric sepsis: identification of oxidative stress-related subtypes and diagnostic biomarkers through integrated bioinformatics analysis	5
Repurposing of piracetam to alleviate doxorubicin-induced cardiotoxicity in rats: targeting TLR2/MyD88/AP-1/NF-κB and VEGF/eNOS signaling pathways	5
Comparison of carcinogenic potential of alternative tobacco products. A systematic review	5