Toxicology Mechanisms and Methods

Article	Citations
Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development	85
Treatment of oxidative stress, apoptosis, and DNA injury with N-acetylcysteine at simulative pesticide toxicity in fish	32
Relevant essential oil components: a minireview on increasing applications and potential toxicity	30
Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis	30
Exosomes derived from bone marrow mesenchymal stem cells reverse epithelial-mesenchymal transition potentially via attenuating Wnt/β-catenin signaling to alleviate silica-induced pulmonary fibrosis	22
Toxicity, preparation methods and applications of silver nanoparticles: an update	22
Phosgene: toxicology, animal models, and medical countermeasures	21
Effects of arsenic exposure on lipid metabolism: a systematic review and meta-analysis	20
Combinative ex vivo studies and in silico models ProTox-II for investigating the toxicity of chemicals used mainly in cosmetic products	19
Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation	19
Deferoxamine ameliorated Al(mal)3-induced neuronal ferroptosis in adult rats by chelating brain iron to attenuate oxidative damage	18
Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials	17
Curcumin reverses hepatic epithelial mesenchymal transition induced by trichloroethylene by inhibiting IL-6R/STAT3	17
Royal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the nrf-2/NF-κB and bcl-2/bax pathway	16
Aristolochic acid induces mitochondrial apoptosis through oxidative stress in rats, leading to liver damage	16
A comprehensive review of treatments for hydrogen sulfide poisoning: past, present, and future	16
Phosgene oxime: a highly toxic urticant and emerging chemical threat	15
Dexamethasone as an anti-cancer or hepatotoxic	15
The searching for agents for Alzheimer’s disease treatment via the system of self-consistent models	14
Effects of imidacloprid on viability and increase of reactive oxygen and nitrogen species in HepG2 cell line	14
Targeting macrophage polarization by Nrf2 agonists for treating various xenobiotics-induced toxic responses	12
Genotoxicity evaluation of silica nanoparticles in murine: a systematic review and meta-analysis	12
The role of levosimendan in phosphine-induced cardiotoxicity: evaluation of electrocardiographic, echocardiographic, and biochemical parameters	11
Development of chlorine-induced lung injury in the anesthetized, spontaneously breathing pig	11
Studying the ophthalmic toxicity potential of developed ketoconazole loaded nanoemulsion in situ gel formulation for ophthalmic administration	11

Fluoride induced testicular toxicities in adult Wistar rats	10
Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease	10
Effects of catechin hydrate in benzo[a]pyrene-induced lung toxicity: roles of oxidative stress, apoptosis, and DNA damage	10
The use of combined high-fructose diet and glyphosate to model rats type 2 diabetes symptomatology	10
Histological and biochemical investigation of the renoprotective effects of metformin in diabetic and prostate cancer model	10
Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity	10
Attenuation of experimentally induced atopic dermatitis in mice by sulforaphane: effect on inflammation and apoptosis	9
Aflatoxin B1 inhibited autophagy flux by inducing lysosomal alkalinization in HepG2 cells	9
Neonatal maternal separation causes decreased numbers of sertoli cell, spermatogenic cells, and sperm in mice	9
Prophylactic effect of probiotics fortified withAloe verapulp nanoemulsion against ethanol-induced gastric ulcer	9
Potential protective effect of catechin on doxorubicin-induced cardiotoxicity in adult male albino rats	9
In vivoandin silicoevaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats	9
A systematic review of preclinical studies on the taurine role during diabetic nephropathy: focused on anti-oxidative, anti-inflammation, and anti-apoptotic effects	9
The antioxidant study proprieties ofThymus munbyanusaqueous extract and its beneficial effect on 2, 4-Dichlorophenoxyacetic acid -induced hepatic oxidative stress in albino Wistar rats	8
Dexmedetomidine provides protection to neurons against OGD/R-induced oxidative stress and neuronal apoptosis	8
Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling	8
Conjugated linoleic acid protects brain mitochondrial function in acrolein induced male rats	8
Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma	8
Induction of genotoxicity and differential alterations of p53 and inflammatory cytokines expression by acute oral exposure to bulk- or nano-calcium hydroxide particles in mice "Genotoxicity of norm	8
Cardioprotective effects of corilagin on doxorubicin induced cardiotoxicity via P13K/Akt and NF-κB signaling pathways in a rat model	8
Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats	8
Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and Parkin in Pb and β-amyloid peptide induced toxicity	8
N-acetylcysteine ameliorates monocrotophos exposure-induced mitochondrial dysfunctions in rat liver	7
Review of data on chemical content in an aerosol resulting from heating a tobacco or a solution used in e-cigarettes and in the smoke generated from the reference cigarettes	7
Exposure of calcium carbide induces apoptosis in mammalian fibroblast L929 cells	7
MiR-191 downregulation protects against isoflurane-induced neurotoxicity through targeting BDNF	7
Modification of the hemodynamic and molecular features of phosphine, a potent mitochondrial toxicant in the heart, by cannabidiol	7
Cytotoxicity, oxidative stress, and inflammatory response of smokeless tobacco extracts and cytotoxicity of combustible cigarette whole smoke in a 3D oral organotypic buccal cell model	7
Bidirectional role of reactive oxygen species during inflammasome activation in acrolein-induced human EAhy926 cells pyroptosis	7
In vitro effect of DDE exposure on the regulation of B-TC-6 pancreatic beta cell insulin secretion: a potential role in beta cell dysfunction and type 2 diabetes mellitus	7
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damag	7
The absence of genotoxicity of a mixture of aloin A and B and a commercial aloe gel beverage	6
Nano-CuO causes cell damage through activation of dose-dependent autophagy and mitochondrial lncCyt b-AS/ND5-AS/ND6-AS in SH-SY5Y cells	6
Schisandrin A alleviates mycophenolic acid-induced intestinal toxicity by regulating cell apoptosis and oxidative damage	6
Sterigmatocystin-induced DNA damage triggers cell-cycle arrestviaMAPK in human neuroblastoma cells	6
Combination of oxytetracycline and quinocetone synergistically induces hepatotoxicity via generation of reactive oxygen species and activation of mitochondrial pathway	6
Comparative outcomes of exposing human liver and kidney cell lines to tungstate and molybdate	6
New Multi-Walled carbon nanotube of industrial interest induce cell death in murine fibroblast cells	6
The effects of prenatal and lactational bisphenol A and/or di(2-ethylhexyl) phthalate exposure on female reproductive system	6
Neuroprotective potential of trimetazidine against tramadol-induced neurotoxicity: role of PI3K/Akt/mTOR signaling pathways	6
Comparison of the effect of vitamin C and selenium nanoparticles on gentamicin-induced renal impairment in male rats: a biochemical, molecular and histological study	6
Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis	6
Acute and sub-acute toxicity study reveals no dentrimental effect of formononetin in mice upon repeated i.p. dosing	6
Hematotoxic, oxidative and genotoxic damage in rainbow trout (Oncorhynchus mykiss) after exposure to 3-benzoylpyridine	6
Grape seed extract proanthocyanidin antagonizes aristolochic acid I-induced liver injury in rats by activating PI3K-AKT pathway	6
Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells	6
Cardioprotective effect of allyl isothiocyanate in a rat model of doxorubicin acute toxicity	6
Naringenin alleviates hepatic injury in zinc oxide nanoparticles exposed rats: impact on oxido-inflammatory stress and apoptotic cell death	6
Antioxidant and antiproliferative effects of Teucrium polium extract: computational and in vivo study in rats	6
Autophagy up-regulated by MEK/ERK promotes the repair of DNA damage caused by aflatoxin B1	5

Resveratrol may dose-dependently modulate nephrin and OTULIN levels in a doxorubicin-induced nephrotoxicity model	5
Neuroprotective effect of miR-212-5p on isoflurane-induced cognitive dysfunction by inhibiting neuroinflammation	5
Evaluating the protective role of Deglycyrrhizinated licorice root supplement on bleomycin induced pulmonary oxidative damage	5
Evaluation of doxorubicin-induced early multi-organ toxicity in male CD1 mice by biodistribution of18F-FDG and67Ga-citrate. Pilot study	5
Safety assessment of a novel water-soluble extract of Boswellia serrata gum resin: acute toxicity, 90-day sub-chronic toxicity, Ames’ bacterial reverse mutation, and in vivo micronucleus	5
Crotonaldehyde exposure induces liver dysfunction and mitochondrial energy metabolism disorder in rats	5
Neuroprotective effect of Morin via TrkB/Akt pathway against diabetes mediated oxidative stress and apoptosis in neuronal cells	5
Antihyperlipidemic effect of tyrosol, a phenolic compound in streptozotocin-induced diabetic rats	5
Analysis of cytotoxicity and genotoxicity in a short-term dependent manner induced by a new titanium dioxide nanoparticle in murine fibroblast cells	5
Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-κB/TLR4 signals	5
Molecular signatures associated with diuron exposure on rat urothelial mitochondria	5
Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids	5
Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin	5
Effects of smokeless tobacco on cell viability, reactive oxygen species, apoptosis, and inflammatory cytokines in human umbilical vein endothelial cells	5
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain	4
An integrated in silico and in vivo approach to determine the effects of three commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate on	4
The involvement of Nrf2/HO-1/cytoglobin and Ang-II/NF-κB signals in the cardioprotective mechanism of lansoprazole against cisplatin-induced heart injury	4
Isoflurane alleviates hypoxia/reoxygenation induced myocardial injury by reducing miR-744 mediated SIRT6	4
Serum α-SMA is a potential noninvasive biomarker of liver fibrosis	4
Comparison of effects of tobacco cigarettes, electronic nicotine delivery systems and tobacco heating products on miRNA-mediated gene expression. A systematic review	4
A novel anticancer chromeno-pyrimidine analogue inhibits epithelial-mesenchymal transition in lung adenocarcinoma cells	4
Fluoride effects on cell viability and ENaC expression in kidney epithelial cells	4
Neuroprotective effect ofBryophyllum pinnatumflavonoids against aluminum chloride-induced neurotoxicity in rats	4
Effects of bisphenol A and S on blood coagulation: in vivo, in vitro and in silico approaches in toxicodynamic	4
Fermented whey modulated AFB1 and OTA-induced hepatotoxicity and nephrotoxicity in vivo. A relative and absolute quantification about sex differences	4
Toxicological analyses: analytical method validation for prevention or diagnosis	4
Interaction of quercetin and 5-fluorouracil: cellular and pharmacokinetic study	4
Methylglyoxal disturbs DNA repair and glyoxalase I system in Saccharomyces cerevisiae	4
The protective effect of co-administration of platelet-rich plasma (PRP) and pentoxifylline (PTX) on cyclophosphamide-induced premature ovarian failure in mature and immature rats	4
Evaluation of cytotoxicity, analysis of metals and cumulative risk assessment in microalgae	4
Estimation of mandarin peel oil–induced cytotoxicity and genotoxicity in human normal fibroblast and cancerous prostate cell lines	4
Antioxidant thymoquinone and eugenol alleviate TiO2nanoparticle-induced toxicity in human blood cellsin vitro	4
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis	4
Acute promyelocytic leukemia drug – arsenic trioxide in the presence of eugenol shows differential action on leukemia cells (HL-60) and cardiomyocytes (H9c2) – inference from NMR study	4
Identification of differentially expressed genes and pathways in diquat and paraquat poisoning using bioinformatics analysis	4
The Strategic National Stockpile: identification, support, and acquisition of medical countermeasures for CBRN incidents	4
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling	4
Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p	4
Vitamin B12 alleviates malathion-induced toxicity in zebra fish by regulating cytochrome P450 and PgP expressions	4
Genotoxicity mechanism of food preservative propionic acid in the in vivo Drosophila model: gut damage, oxidative stress, cellular immune response and DNA damage	4
Evaluation of Calu-3 cell lines as anin vitromodel to study the inhalation toxicity of flavoring extracts	3
The fluorosis conundrum: bridging the gap between science and public health	3
Oleanolic acid-based therapeutics ameliorate rotenone-induced motor and depressive behaviors in parkinsonian male mice via controlling neuroinflammation and activating Nrf2-BDNF-dopaminergic signaling	3
Use of clinical chemistry health outcomes and PFAS chain length to predict 28-day rodent oral toxicity	3
Rotenone induces hepatotoxicity in rats by activating the mitochondrial pathway of apoptosis	3
Special issue: emerging chemical terrorism threats	3
Short/long-term cryopreservation prior to comet assay of whole-blood leukocytes and in vitro-cultured lung fibroblasts	3
Contaminant microorganisms in the in vitro evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation	3
Enhancing global and local decision making for chemical safety assessments through increasing the availability of data	3
Degradation of phosalone by silver ion catalytic hydrolysis	3
An in vitro human assay for evaluating immunogenic and sensitization potential of a personal care and cosmetic product	3
Bone marrow mononuclear cells boosts anti-cytogentical aberration effect of N-acetylcysteine and α-lipoic acid in rat’s liver and bone marrow: implication of oxidative and inflammatory pathways	3
Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236	3
The effect of GSK-3β in arsenic-induced apoptosis of malignant tumor cells: a systematic review and meta-analysis	3
Implications for herbal polypharmacy: coumarin-induced hepatotoxicity increased through common herbal phytochemicals astragaloside IV and atractylenolide I	3
Glycoprotein levels and oxidative lung injury in experimental diabetes: effect of oxovanadium(IV) complex based on thiosemicarbazone	3
Ramelteon and mechanism of its restorative effect in an experimental lung disease model	3
Chebulagic acid attenuates HFD/streptozotocin induced impaired glucose metabolism and insulin resistance via up regulations of PPAR γ and GLUT 4 in type 2 diabetic rats	3
Development of reliable quantitative structure–toxicity relationship models for toxicity prediction of benzene derivatives using semiempirical descriptors	3
Analysis of toxicity effects of delta-9-tetrahydrocannabinol on isolated rat heart mitochondria	3
Toxicity effects evaluation of green synthesized silver nanoparticles on intraperitoneally exposed male Wistar rats	3
Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats	3
Integrating network pharmacology and in vitro model to investigate hippocampal neurotoxicity induced by atrazine	3
Balancing renal Ang-II/Ang-(1–7) by xanthenone; an ACE2 activator; contributes to the attenuation of Ang-II/p38 MAPK/NF-κB p65 and Bax/caspase-3 pathways in amphotericin B-induced nephrotoxicity in ra	3
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells	3
Application of three-dimensional Raman imaging to determination of the relationship between cellular localization of diesel exhaust particles and the toxicity	3
Long noncoding RNAs: biogenesis, regulation, function, and their emerging significance in toxicology	3
Drug target genes and molecular mechanism investigation in isoflurane-induced anesthesia based on WGCNA and machine learning methods	3
Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice	3
Myocardial infarction and oxidative damage in animal models: objective and expectations from the application of cysteine derivatives	3
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production	3
Effect of iodinated contrast media on peripheral blood mononuclear cells in terms of cell viability, cell cycle and oxidative stress in an in vitro system	3
Lasso-Logistic regression model for the identification of serum biomarkers of neurotoxicity induced by strychnos alkaloids	3
A simple protocol for estimating the acute toxicity of unresolved polar compounds from field-weathered oils	2
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague–Dawley rats; action mechanisms and signaling pathways	2
Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 4	2
Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithel	2
Pharmacological prophylaxis with pyridostigmine bromide against nerve agents adversely impact on airway function in an ex vivo rat precision-cut lung slice model	2
The STING-IRF3 pathway contributes to paraquat-induced acute lung injury	2
C–Glucosyl Xanthone derivative Mangiferin downregulates the JNK3 mediated caspase activation in Almal induced neurotoxicity in differentiated SHSY-5Y neuroblastoma cells	2

A critical assessment of the whole plant-based phytotherapeutics from Withania somnifera (L.) Dunal with respect to safety and efficacy vis-a-vis leaf or root extract-ba	2
Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin	2
The neuroprotective effect of mesenchymal stem cells in colistin-induced neurotoxicity	2
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis	2
Significant shifts in preclinical and clinical neurotoxicology: a review and commentary	2
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model	2
The stability of cyanide in human biological samples. A systematic review, meta-analysis and determination of cyanide (GC-QqQ-MS/MS) in an authentic casework 7 years after fatal intoxication	2
Design of a microfluidic lung chip and its application in assessing the toxicity of formaldehyde	2
Synthesis of salicylic acid from wintergreen oil by green chemistry overcomes its cytotoxicity in keratinocyte cells and teratogenicity in zebrafish embryos	2
Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells	2
The changes of MRP2 expression in three kinds of pulmonary inflammation models: the downregulation occurred in cigarette smoke extract (CSE) stimulation group and CSE plus LPS stimulation group, uncha	2
Study of the acute and repeated dose 28-day oral toxicity in mice treated with PT-31, a molecule with a potential antipsychotic profile	2
miR-26a-5p protects against drug-induced liver injury via targeting bid	2
Morphine ameliorates pentylenetetrazole-induced locomotor pattern in zebrafish embryos; mechanism involving regulation of opioid receptors, suppression of oxidative stress, and inflammation in epilept	2
The mechanism of miR-363-3p/DUSP10 signaling pathway involved in the gastric mucosal injury induced by clopidogrel	2
Lauric acid attenuates hepato-metabolic complications and molecular alterations in high-fat diet-induced nonalcoholic fatty liver disease in rats	2
Safety assessment of a novel, dietary pyrroloquinoline quinone disodium salt (mnemoPQQ®)	2