Toxicology Mechanisms and Methods

Article	Citations
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells	57
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis	42
Human stromal cell-based protocol to generate astrocytes: a straightforward in vitro predictive strategy in neurotoxicology	34
Effects of acute carbon monoxide poisoning on liver damage and comparisons of related oxygen therapies in a rat model	27
Assessment of docosahexaenoic acid’s preventive efficacy against unconjugated bilirubin neurotoxicity through MRP1 protein expression	24
Evaluation of the protective effects of curcumin-rich turmeric ( Curcuma longa ) extract against isotretinoin-induced liver damage in rats	23
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment	22
Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 4	22
An improved method for toxicological profiling of chemical substances	22
Maternal long-term inhalation exposure to perchloroethylene and prenatal teratogenicity: morphometric, hormonal, and histological study	21
Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study	19
Mechanistic paradigms of immunotoxicity, triggered by nanoparticles – a review	19
Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236	17
A microvolume protocol for catalase activity	16
M3Hep: a multimodal hepatotoxicity prediction model combining mitochondrial toxicity and masking strategy	16
Chronological activation of the NLRP3 inflammasome/pyroptosis pathway in the progression from metabolic dysfunction-associated fatty liver disease to hepatocellular carcinoma	16
A simple protocol for estimating the acute toxicity of unresolved polar compounds from field-weathered oils	15
Establishing a link between the chemical composition and biological activities of Gladiolus italicus Mill. from the Turkish flora utilizing in vitro	15
Flow-through imaging and automated analysis of oil-exposed early stage Atlantic cod ( Gadus morhua )	15
Implications of plastic-derived endocrine disruptors on human health	14
Computational toxicology of N -nitrosamine impurities: from molecular structure to regulatory concern	13
Leveraging AlphaFold models to predict androgenic effects of endocrine-disrupting chemicals through zebrafish androgen receptor analysis	13
Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids	13
A novel in vitro assay for rapid screening of embryotoxicity in multiple species	12
Evaluation of cytotoxicity, analysis of metals and cumulative risk assessment in microalgae	12

Correction	12
Mitochondrial toxic prediction of marine alga toxins using a predictive model based on feature coupling and ensemble learning algorithms	12
Alcohol-induced hormonal and metabolic alterations in plasma and erythrocytes—a gender-based study	11
Combined effects and potential mechanisms of volatile organic compounds on childhood asthma in the US population: an integrated epidemiological and computational toxicology study	11
Third party product certification for drinking water health effects	10
Potential risk of premature ovarian insufficiency from atrazine exposure: insights into molecular pathways and regulatory implications	10
3-Formylchromone attenuates urethane-induced lung carcinogenesis and enhances gefitinib anti-tumor response via modulation of IL-6/JAK1/STAT3/cyclin D1 signaling	10
Time-course cross-species transcriptomics reveals conserved hepatotoxicity pathways induced by repeated administration of cyclosporine A	10
Decoding the possible mechanism of action of Paeoniflorigenone in combating Aflatoxin B1-induced liver cancer: an investigation using network pharmacology and bioinformatics analysis	10
Dexamethasone as an anti-cancer or hepatotoxic	10
Bioinformatics analysis of differentially expressed genes related to ischemia and hypoxia in spinal cord injury and construction of miRNA-mRNA or mRNA-transcription factor interaction network	10
PM 2.5 -induced DNA oxidative stress in A549 cells and regulating mechanisms by GST DNA methylation and Keap1/Nrf2 pathway	10
Mitochondria under fire: toxicological mechanisms of brominated flame retardants	10
Toxicological impact of copper nanoparticles on rainbow trout: hematological, biochemical, antioxidant, and histopathological responses with oxidative gene expression	10
The stability of cyanide in human biological samples. A systematic review, meta-analysis and determination of cyanide (GC-QqQ-MS/MS) in an authentic casework 7 years after fatal intoxication	9
Acute oral toxicity evaluation of microencapsulated semi-purified fibrinolytic proteases using a modified OECD 423–aligned design for biotechnological applications	9
Aloe-emodin upregulates DUSP1 to alleviate aristolochic acid-induced renal tubular epithelial cell damage	9
E-cigarette aerosols as systemic metabolic disruptors: integrated mitochondrial, circadian, and neurobehavioral mechanisms	9
Investigation of some metal levels in people using electronic cigarettes and IQOS	9
Neurotoxicity mechanisms of pyrethroids studied by network toxicology and molecular docking	9
Diacerein counteracts amiodarone‑induced hepatotoxicity in rats via targeting TLR4/NF-kB/NLRP3 pathways	9
Should ebselen be considered for the treatment of mercury intoxication? A minireview	9
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production	9
Nano and microplastics: unveiling their profound impact on endocrine health	9
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model	8
Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ	8
Effects of pumpkin and fermented whey on fecal microbiota profile against AFB1 and OTA exposure in Wistar rats	8
Behavioral pharmacology and toxicology of dimethyl sulfoxide in artemia nauplii: vehicle or positive control?	8
Evaluation of acute, subacute, subchronic, reproductive, and genotoxicity of a standardized extract from the bark of Oroxylum indicum	8
Raptors as sentinels: unveiling the environmental and health risks of PFAS contamination	8
Significant shifts in preclinical and clinical neurotoxicology: a review and commentary	8
5-Hydroxymethylfurfural causes reproductive toxicity in male mice by increasing oxidative stress and apoptosis through the Nrf2/HO-1 signaling pathway	8
PM2.5 mediates mouse testis Sertoli TM4 cell damage by reducing cellular NAD +	8
Comparative stability assessment of synthetic cannabinoids in dry blood spots and blood using UHPLC-MS/MS: implications for forensic applications	7
Use of TLM derived models to estimate toxicity of weathered MC252 oil based on conventional chemical data and the potential impact of unresolved polar components	7
Comparative screening of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity using spectroscopic and electrometric techniques	7
In silico aquatic toxicity prediction of chemicals toward Daphnia magna and fathead minnow using Monte Carlo approaches	7
Role of connexin32 in zinc oxide nanoparticles induced hepatotoxicity	7
Syringic acid exhibits ameliorative effects against cyclosporine A-induced cardiotoxicity in mice by mitigating oxidative stress, inflammatory response, and apoptotic cell death	7
Does the accounting of the local symmetry fragments in quasi-SMILES improve the predictive potential of the QSAR models of toxicity toward tadpoles?	7
An in silico toxicogenomic approach in constructing the aflatoxin B1-mediated regulatory network of hub genes in hepatocellular carcinoma	6
Effects of organophosphates on precision-cut kidney slices	6
Development of mass spectrometric methods for determination of desoxycorticosterone pivalate and its esterase product in canine serum	6
Tobacco-specific nitrosamine ‘4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)’: toxicological mechanisms, carcinogenicity, and chemopreventive approaches	6
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain	6
Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells	6
Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers	6
Evaluation of novel surfactants for the decontamination of chemical warfare agents	6
Nephroprotective role of edaravone against polystyrene nanoplastic-induced endoplasmic reticulum stress in Wistar rats	6
Evidence of binding between diethylstilbestrol (DES) and the goldfish ( Carassius auratus ) membrane progesterone receptor α	6

Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice	6
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague–Dawley rats; action mechanisms and signaling pathways	6
Modulating oxidative stress, apoptosis, and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol	6
Enhanced kidney damage induced by increasing nonylphenol doses: impact on autophagy-related proteins and proinflammatory cytokines in rats	5
Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (Macaca mulatta)	5
Cisplatin-induced renal toxicity: an integrated view of molecular pathways and emerging therapeutic targets—a comprehensive review	5
Safety and efficacy of a novel phytoceutical formulation CL18100F4 in increasing gut motility and improving stool consistency in animals	5
Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin	5
Metformin attenuates PM 2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells	5
Protective effects of polysaccharide extracted from green alga Chaetomorpha linum against zinc and copper-induced testicular toxicity in male mice	5
Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats	5
Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway	5
Malondialdehyde and nitric oxide levels reveal comparative toxicity of three insecticides in wistar rats	5
Correction	5
Molecular heterogeneity in pediatric sepsis: identification of oxidative stress-related subtypes and diagnostic biomarkers through integrated bioinformatics analysis	5
Clinical and safety outcomes associated with aristolochic acid exposure: a systematic review and meta-analysis	5
Repurposing of piracetam to alleviate doxorubicin-induced cardiotoxicity in rats: targeting TLR2/MyD88/AP-1/NF-κB and VEGF/eNOS signaling pathways	5
Enhanced anti-cancer efficacy of Sorafenib and Pioglitazone via VEGF inhibition in DMBA-induced breast cancer model	5
Comparison of carcinogenic potential of alternative tobacco products. A systematic review	5
The flavonoid hyperoside attenuates the toxic effect of cisplatin on the human ovarian granulosa cells: in vitro model study	5
Transcriptomic profiling reveals crizotinib-induced hepatotoxicity through ROS-mediated activation of the JNK/NLRP3 pathway	4
Naturally-derived phenethyl isothiocyanate modulates apoptotic induction through regulation of the intrinsic cascade and resulting apoptosome formation in human malignant melanoma cells	4
Quercetin induces ferroptosis by inactivating mTOR/S6KP70 pathway in oral squamous cell carcinoma	4
Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma	4
Phytohemagglutinin-induced NF-κB/MAPK activation stimulates a broad immune checkpoint-positive T cell model	4
Non-monotonic effects of Bisphenol A Dimethacrylate on male mouse reproductive system and fertility leads to impaired conceptive performance	4
Inhalation safety and tolerability of a novel fixed-dose combination of glycopyrronium–vilanterol powder in Wistar rats	4
Safety assessment of high fructose corn syrup and fructose used as sweeteners in foods	4
Sentinel role of military dogs in detecting genotoxic agents in the environment during military operations: a pilot study	4
Zebrafish larvae locomotion bioassay: application on nanofractionated Naja nigricollis venom	4
Development of reliable quantitative structure–toxicity relationship models for toxicity prediction of benzene derivatives using semiempirical descriptors	4
Lauric acid attenuates hepato-metabolic complications and molecular alterations in high-fat diet-induced nonalcoholic fatty liver disease in rats	4
Neurotoxic and metabolic effects of chronic aspartame consumption in rodent models: a systematic review and meta-analysis	4
Motor-evoked potentials after focal electrical stimulation predict drug-induced convulsion potentials in rats	4
Ertugliflozin ameliorates thioacetamide-induced renal injury by modulating Nrf2-mediated oxidative stress, TLR4/STAT3 inflammatory signaling, and YAP/TAZ fibrotic pathways	4
Mouse precision-cut liver and kidney slices: an optimized ex vivo model for organotoxicity testing	4
Potential of Fenfuro ® , a novel, standardized Trigonella foenum-graecum (Fenugreek) seed extract, in	4
In vivo , in vitro , and in silico toxicology studies of nanoplastics and their	4
Cereulide-Mediated Emetic (Vomiting) Toxicity of Bacillus cereus in Infant Formula: Mitochondrial Mechanisms, Analytical Methods, and Risk Assessment	4
Integrating NHANES and network toxicology to assess the impact of organophosphate flame retardants on cardiovascular disease	4
Gas chromatography-tandem mass spectrometric analysis of metaldehyde and its metabolite acetaldehyde in initial assessment of hemodialysis abatement of toxicity in live animals	4
Real-time monitoring of microplastic accumulation in fish bodies using transparent goldfish revealed initial attack on the gill	4
Novel insights into the mechanism of formaldehyde-induced lung cancer: a network toxicology and molecular docking approach	3
Effects of benzoic acid synthesized from Cinnamomum cassia by green chemistry on valproic acid-induced neurotoxicity in zebrafish embryos	3
Ramelteon and mechanism of its restorative effect in an experimental lung disease model	3
Undifferentiated versus retinoic acid-differentiated SH-SY5Y cells in investigation of markers of neural function in toxicological research	3
Acutely increased aquaporin-4 exhibits more potent protective effects in the cortex against single and repeated isoflurane-induced neurotoxicity in the developing rat brain	3
Ontogenetic development of metabolic and detoxification genes in Seriola rivoliana larvae	3
Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-κB/TLR4 signals	3
UR-144, synthetic cannabinoid receptor agonist, induced cardiomyoblast toxicity mechanism comprises cytoplasmic Ca2+and DAPK1 related autophagy and necrosis	3
Silver nanoparticle toxicity in rainbow trout: insights into physiological and molecular responses	3
A QSAR study for predicting malformation in zebrafish embryo	3
An ex vivo model to evaluate DNA damage by comet assay in breast-cancer tissue	3
Application of the C-BED tool in the analysis of the effect of norfluoxetine as an EDC on the marine mussel Mytilus trossulus	3
Introducing AutoML framework for drug–drug interaction prediction: application of AutoGluon	3
Atrazine modifies markers of melanocyte maturation and apoptosis in primary skin cultures	3
Statement of Retraction: Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-κB inhibitor against HeLa human cell line	3
Impacts on gene expression profiles associated with the most widely used pesticides in Central Brazil	3
Insights into mitochondrial creatine kinase: examining preventive role of creatine supplement in doxorubicin-induced cardiotoxicity	3
Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin	3
Using machine learning to classify the immunosuppressive activity of per- and polyfluoroalkyl substances	3
The multifaceted effects of rosmarinic acid on breast cancer, regulating autophagy and increasing apoptosis	3
Unveiling the toxicity and mechanisms of 2,4-dichlorophenoxyacetic acid in hypertension: a molecular-level perspective	3
Impact of ethanol as a vehicle for water-insoluble pollutants in BEAS-2B cell toxicity assays	3
Arsenic–cadmium co-exposure rewires lipid–iron homeostasis to drive ferroptosis in human proximal tubular cells	3
Elucidating the impact of PFAS exposure on diabetes through integrated network toxicology	3
Pharmacological prophylaxis with pyridostigmine bromide against nerve agents adversely impact on airway function in an ex vivo rat precision-cut lung slice model	3
Unraveling nitrosamine-induced carcinogenesis: toxicological aspects and molecular insights	3
Optimization of long-term incubation of precision-cut kidney slices	3
Polystyrene nanoplastics induce pyroptosis in HepG2 cells via the YAP1-cGAS-STING signaling axis	3
Network toxicology analysis reveals molecular mechanisms associated with noise exposure to multiple diseases	3
Cosmetic preservatives: physicochemical descriptors, mechanistic toxicity, and methodological approaches	3
Oleanolic acid-based therapeutics ameliorate rotenone-induced motor and depressive behaviors in parkinsonian male mice via controlling neuroinflammation and activating Nrf2-BDNF-dopaminergic signaling	3
Fermented whey modulated AFB1 and OTA-induced hepatotoxicity and nephrotoxicity in vivo. A relative and absolute quantification about sex differences	3
L-arginine and tetrahydrobiopterin alleviate mercury-induced vascular dysfunction by modulating angiotensin II receptors (AT1, AT2) and ACE2 activity in rat aortic rings	3
6-pentadecyl salicylic acid reduces cell proliferation in U373MG glioblastoma cells via glutamine uptake impairment	3
Drug target genes and molecular mechanism investigation in isoflurane-induced anesthesia based on WGCNA and machine learning methods	3
Evaluation and comparison of DNA alkylation and oxidative damage in e-cigarette and heated tobacco users	2
From historical drugs to present perils: UHPLC-QqQ-MS/MS determination of methaqualone and its designer analogs (NPS) with comprehensive fragmentation pathways study (QTOF)	2
Leflunomide-induced cardiac injury in adult male mice and bioinformatic approach identifying Nrf2/NF-κb signaling interplay	2

Oxidative stress contributes to coffee constituent toxicity in SH-SY5Y neuroblastoma cells	2
Computational evidence of cancer and reproductive toxicological potential from short-chain PFAS exposure through network toxicology and docking approaches	2
Detection of endocrine and metabolism disrupting xenobiotics in milk-derived fat samples by fluorescent protein-tagged nuclear receptors and live cell imaging	2
Development of a gradual hypoxia chamber for assessing copper toxicity on air-breathing behavior in Lymnaea stagnalis	2
Mechanistic insights into the impact of WIN 55, 212-2, a synthetic cannabinoid, on adhesion molecules PECAM-1 and VE-cadherin in HeLa cells: implications on cancer processes	2
The system of self-consistent models for pesticide toxicity to Daphnia magna	2
Propofol alleviates traumatic brain injury through regulating Th17/Treg balance by activation of the AMPK/SIRT1 pathway	2
Mechanisms involved in the valproic acid-induced hepatotoxicity: a comprehensive review	2
Establishment of a strategy using alternative methods to the use of animals to evaluate the ocular irritant potential of cosmetics for styling, braiding, or fixing hair	2
Differential effects of OATP2B1 on statin accumulation and toxicity in a beta cell model	2
Obesity aggravates neuroinflammatory and neurodegenerative effects of bisphenol A in female rats	2
Lauric acid attenuates hepatic lipid metabolism by modulating the AMPK-SREBP pathway in high-fat diet-induced obese mice	2
Application and prospect of organoids in tobacco product safety and risk evaluation	2
Serum α-SMA is a potential noninvasive biomarker of liver fibrosis	2
Effect of iodinated contrast media on peripheral blood mononuclear cells in terms of cell viability, cell cycle and oxidative stress in an in vitro system	2
Furan promotes cytotoxic effects through DNA damage and cell apoptosis in Leydig cells	2
Quantitative methods for the risk assessment of drinking water contact chemicals following the NSF/ANSI/CAN 600 standard – part I: general methods	2
Cinobufagin induced myocardial cell toxicity in H9c2 cells via inhibiting histone methyltransferase SMYD1 expression	2
Drug reactive metabolite-induced hepatotoxicity: a comprehensive review	2
Exploring the impact of ambient air PM 2.5 on multiple sclerosis: an experimental dive into neuroinflammation	2
Neuroprotective effect of marrubiin against MPTP-induced experimental Parkinson’s disease in male wistar rats	2
Interpretable multi-modality consensus QSAR framework: integrating machine and deep learning for enhanced multi-endpoint toxicity assessment	2
Leveraging new approach methodologies: ecotoxicological modelling of endocrine disrupting chemicals to Danio rerio through machine learning and toxicity studies	2
Identification and verification of characteristic differentially expressed ferroptosis-related genes in osteosarcoma using bioinformatics analysis	2
Neodymium nitrate promotes the apoptosis of mouse liver cells via Bcl2l1/Caspase 3 pathway	2
Targeting lipid–fibrotic signaling crosstalk for antifibrotic therapy	2
Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice	2
New mechanistic approach of TiCN film-coated NiTi substrate toxicity: impairment in mitochondrial electron transfer in diabetic rat tooth gum cells	2
In silico and in vivo toxicity assessment of cysteamine-modified nanoparticles: implications for pharmacotherapy application	2
Mass spectrometric methods for evaluation of voriconazole avian pharmacokinetics and the inhibition of its cytochrome P450-induced metabolism	2
Isoflurane pretreatment protects against myocardial ischemia/reperfusion injury via mediating lncRNA CASC15/miR-542-3p axis	2
Identification of miRNAs and target genes associated with lymph node metastasis in cervical cancer using bioinformatics analysis	2
Bioinformatics analysis to identify endocrine-disrupting chemicals targeting key ESCC-related genes	2
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling	2
Disruptive multiple cell death pathways of bisphenol-A	2
Design of a microfluidic lung chip and its application in assessing the toxicity of formaldehyde	2