Toxicology Mechanisms and Methods

Article	Citations
An improved method for toxicological profiling of chemical substances	128
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment	36
Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells	36
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells	29
Evaluation of the protective effects of curcumin-rich turmeric ( Curcuma longa ) extract against isotretinoin-induced liver damage in rats	26
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis	26
Human stromal cell-based protocol to generate astrocytes: a straightforward in vitro predictive strategy in neurotoxicology	26
Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 4	25
Effects of acute carbon monoxide poisoning on liver damage and comparisons of related oxygen therapies in a rat model	23
Evaluating the protective role of Deglycyrrhizinated licorice root supplement on bleomycin induced pulmonary oxidative damage	22
Maternal long-term inhalation exposure to perchloroethylene and prenatal teratogenicity: morphometric, hormonal, and histological study	21
A simple protocol for estimating the acute toxicity of unresolved polar compounds from field-weathered oils	20
Neuroprotective effect ofBryophyllum pinnatumflavonoids against aluminum chloride-induced neurotoxicity in rats	19
Mechanistic paradigms of immunotoxicity, triggered by nanoparticles – a review	19
Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236	19
Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study	17
Flow-through imaging and automated analysis of oil-exposed early stage Atlantic cod ( Gadus morhua )	16
Correction	14
Establishing a link between the chemical composition and biological activities of Gladiolus italicus Mill. from the Turkish flora utilizing in vitro	14
Alcohol-induced hormonal and metabolic alterations in plasma and erythrocytes—a gender-based study	14
Evaluation of cytotoxicity, analysis of metals and cumulative risk assessment in microalgae	14
Mitochondrial toxic prediction of marine alga toxins using a predictive model based on feature coupling and ensemble learning algorithms	13
Leveraging AlphaFold models to predict androgenic effects of endocrine-disrupting chemicals through zebrafish androgen receptor analysis	13
Correction	13
Toxicological impact of copper nanoparticles on rainbow trout: hematological, biochemical, antioxidant, and histopathological responses with oxidative gene expression	13

Concerted hepatoprotective effect of bradykinin potentiating factor and low dose of γ- radiation on Naja haje envenomed rats via Bax/Bcl2 pathway	12
Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids	12
Dexamethasone as an anti-cancer or hepatotoxic	12
The protective effect of co-administration of platelet-rich plasma (PRP) and pentoxifylline (PTX) on cyclophosphamide-induced premature ovarian failure in mature and immature rats	12
Time-course cross-species transcriptomics reveals conserved hepatotoxicity pathways induced by repeated administration of cyclosporine A	11
Third party product certification for drinking water health effects	11
Decoding the possible mechanism of action of Paeoniflorigenone in combating Aflatoxin B1-induced liver cancer: an investigation using network pharmacology and bioinformatics analysis	10
The stability of cyanide in human biological samples. A systematic review, meta-analysis and determination of cyanide (GC-QqQ-MS/MS) in an authentic casework 7 years after fatal intoxication	10
Precision-cut liver slices as a model for assess hepatic cellular response of chitosan–glutathione nanoparticles on cultures treated with zilpaterol and clenbuterol	10
Bioinformatics analysis of differentially expressed genes related to ischemia and hypoxia in spinal cord injury and construction of miRNA-mRNA or mRNA-transcription factor interaction network	10
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production	10
Should ebselen be considered for the treatment of mercury intoxication? A minireview	10
PM2.5 mediates mouse testis Sertoli TM4 cell damage by reducing cellular NAD +	9
Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ	9
PM 2.5 -induced DNA oxidative stress in A549 cells and regulating mechanisms by GST DNA methylation and Keap1/Nrf2 pathway	9
Effects of pumpkin and fermented whey on fecal microbiota profile against AFB1 and OTA exposure in Wistar rats	9
Molecular signatures associated with diuron exposure on rat urothelial mitochondria	9
Significant shifts in preclinical and clinical neurotoxicology: a review and commentary	9
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model	9
In silico aquatic toxicity prediction of chemicals toward Daphnia magna and fathead minnow using Monte Carlo approaches	8
Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation	8
Antioxidant thymoquinone and eugenol alleviate TiO2nanoparticle-induced toxicity in human blood cellsin vitro	8
Use of TLM derived models to estimate toxicity of weathered MC252 oil based on conventional chemical data and the potential impact of unresolved polar components	8
Does the accounting of the local symmetry fragments in quasi-SMILES improve the predictive potential of the QSAR models of toxicity toward tadpoles?	8
Effects of imidacloprid on viability and increase of reactive oxygen and nitrogen species in HepG2 cell line	8
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague–Dawley rats; action mechanisms and signaling pathways	8
Short/long-term cryopreservation prior to comet assay of whole-blood leukocytes and in vitro-cultured lung fibroblasts	8
Evidence of binding between diethylstilbestrol (DES) and the goldfish ( Carassius auratus ) membrane progesterone receptor α	8
Modulating oxidative stress, apoptosis, and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol	8
Application of three-dimensional Raman imaging to determination of the relationship between cellular localization of diesel exhaust particles and the toxicity	8
Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis	8
An in silico toxicogenomic approach in constructing the aflatoxin B1-mediated regulatory network of hub genes in hepatocellular carcinoma	7
Clinical and safety outcomes associated with aristolochic acid exposure: a systematic review and meta-analysis	7
Effects of organophosphates on precision-cut kidney slices	7
Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice	7
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damag	7
Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers	7
Integrating network pharmacology and in vitro model to investigate hippocampal neurotoxicity induced by atrazine	6
Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and Parkin in Pb and β-amyloid peptide induced toxicity	6
Neuroprotective effect of miR-212-5p on isoflurane-induced cognitive dysfunction by inhibiting neuroinflammation	6
The flavonoid hyperoside attenuates the toxic effect of cisplatin on the human ovarian granulosa cells: in vitro model study	6
Metformin attenuates PM 2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells	6
Antioxidant and antihyperlipidemic activities of catechol derivatives and biflavonoid isolated from Semecarpus anacardium seeds	6
Development of mass spectrometric methods for determination of desoxycorticosterone pivalate and its esterase product in canine serum	6
Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease	6
Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats	6
Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials	6
Deferoxamine ameliorated Al(mal)3-induced neuronal ferroptosis in adult rats by chelating brain iron to attenuate oxidative damage	6
Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin	6
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain	6

Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells	6
Enhanced kidney damage induced by increasing nonylphenol doses: impact on autophagy-related proteins and proinflammatory cytokines in rats	6
Safety assessment of high fructose corn syrup and fructose used as sweeteners in foods	6
Nano-CuO causes cell damage through activation of dose-dependent autophagy and mitochondrial lncCyt b-AS/ND5-AS/ND6-AS in SH-SY5Y cells	6
Gas chromatography-tandem mass spectrometric analysis of metaldehyde and its metabolite acetaldehyde in initial assessment of hemodialysis abatement of toxicity in live animals	5
Neuroprotective effect of Morin via TrkB/Akt pathway against diabetes mediated oxidative stress and apoptosis in neuronal cells	5
Protective effect of Pulsatilla saponin A on acute myocardial infarction via miR-24-3p/p16	5
Molecular heterogeneity in pediatric sepsis: identification of oxidative stress-related subtypes and diagnostic biomarkers through integrated bioinformatics analysis	5
Royal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the nrf-2/NF-κB and bcl-2/bax pathway	5
Motor-evoked potentials after focal electrical stimulation predict drug-induced convulsion potentials in rats	5
Relevant essential oil components: a minireview on increasing applications and potential toxicity	5
Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (Macaca mulatta)	5
Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway	5
Naturally-derived phenethyl isothiocyanate modulates apoptotic induction through regulation of the intrinsic cascade and resulting apoptosome formation in human malignant melanoma cells	5
Modulation of PTZ-induced convulsions in rats using topiramate alone or combined with low dose gamma irradiation: involving AKT/m-TOR pathway	5
Protective effects of polysaccharide extracted from green alga Chaetomorpha linum against zinc and copper-induced testicular toxicity in male mice	5
Effects of catechin hydrate in benzo[a]pyrene-induced lung toxicity: roles of oxidative stress, apoptosis, and DNA damage	5
Lauric acid attenuates hepato-metabolic complications and molecular alterations in high-fat diet-induced nonalcoholic fatty liver disease in rats	4
Development of reliable quantitative structure–toxicity relationship models for toxicity prediction of benzene derivatives using semiempirical descriptors	4
Safety assessment of a novel water-soluble extract of Boswellia serrata gum resin: acute toxicity, 90-day sub-chronic toxicity, Ames’ bacterial reverse mutation, and in vivo micronucleus	4
UR-144, synthetic cannabinoid receptor agonist, induced cardiomyoblast toxicity mechanism comprises cytoplasmic Ca2+and DAPK1 related autophagy and necrosis	4
N-acetylcysteine ameliorates monocrotophos exposure-induced mitochondrial dysfunctions in rat liver	4
Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma	4
Inhalation Safety and Tolerability of a Novel Fixed Dose Combination of Glycopyrronium-Vilanterol Powder in Wistar Rats	4
Pharmacological prophylaxis with pyridostigmine bromide against nerve agents adversely impact on airway function in an ex vivo rat precision-cut lung slice model	4
A QSAR study for predicting malformation in zebrafish embryo	4
Mitigative impact of bradykinin potentiating factor isolated from Androctonus amoreuxi scorpion venom and low doses of γ-irradiation on doxorubicin induced hepatotoxicity through ang II/AMPK cr	4
Proteomic characteristics of PM2.5-induced differentially expressed proteins in k-ras-silenced HBE cells	4
Non-monotonic effects of Bisphenol A Dimethacrylate on male mouse reproductive system and fertility leads to impaired conceptive performance	4
Sentinel role of military dogs in detecting genotoxic agents in the environment during military operations: a pilot study	4
Quercetin induces ferroptosis by inactivating mTOR/S6KP70 pathway in oral squamous cell carcinoma	4
Effects of benzoic acid synthesized from Cinnamomum cassia by green chemistry on valproic acid-induced neurotoxicity in zebrafish embryos	4
Conjugated linoleic acid protects brain mitochondrial function in acrolein induced male rats	4
Drug target genes and molecular mechanism investigation in isoflurane-induced anesthesia based on WGCNA and machine learning methods	4
Using machine learning to classify the immunosuppressive activity of per- and polyfluoroalkyl substances	3
Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-κB/TLR4 signals	3
Optimization of long-term incubation of precision-cut kidney slices	3
An integrated in silico and in vivo approach to determine the effects of three commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate on	3
Ramelteon and mechanism of its restorative effect in an experimental lung disease model	3
Cardioprotective effect of allyl isothiocyanate in a rat model of doxorubicin acute toxicity	3
New mechanistic approach of TiCN film-coated NiTi substrate toxicity: impairment in mitochondrial electron transfer in diabetic rat tooth gum cells	3
Evaluation and comparison of DNA alkylation and oxidative damage in e-cigarette and heated tobacco users	3
Utilizing network pharmacological analysis to investigate the key targets and mechanisms of kaempferol against oxaliplatin-induced neurotoxicity	3
Insights into mitochondrial creatine kinase: examining preventive role of creatine supplement in doxorubicin-induced cardiotoxicity	3
Acutely increased aquaporin-4 exhibits more potent protective effects in the cortex against single and repeated isoflurane-induced neurotoxicity in the developing rat brain	3
Silver nanoparticle toxicity in rainbow trout: insights into physiological and molecular responses	3
Fermented whey modulated AFB1 and OTA-induced hepatotoxicity and nephrotoxicity in vivo. A relative and absolute quantification about sex differences	3
Network toxicology analysis reveals molecular mechanisms associated with noise exposure to multiple diseases	3
Developmental exposure to the A6-pesticide causes changes in tyrosine hydroxylase gene expression, neurochemistry, and locomotors behavior in larval zebrafish	3
Disruptive multiple cell death pathways of bisphenol-A	3
Studying the ophthalmic toxicity potential of developed ketoconazole loaded nanoemulsion in situ gel formulation for ophthalmic administration	3
Effect of iodinated contrast media on peripheral blood mononuclear cells in terms of cell viability, cell cycle and oxidative stress in an in vitro system	3
Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p	3
Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin	3
Oleanolic acid-based therapeutics ameliorate rotenone-induced motor and depressive behaviors in parkinsonian male mice via controlling neuroinflammation and activating Nrf2-BDNF-dopaminergic signaling	3
Statement of Retraction: Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-κB inhibitor against HeLa human cell line	3
The effects of prenatal and lactational bisphenol A and/or di(2-ethylhexyl) phthalate exposure on female reproductive system	3
Atrazine modifies markers of melanocyte maturation and apoptosis in primary skin cultures	3
Undifferentiated versus retinoic acid-differentiated SH-SY5Y cells in investigation of markers of neural function in toxicological research	3
Leflunomide-induced cardiac injury in adult male mice and bioinformatic approach identifying Nrf2/NF-κb signaling interplay	3
From historical drugs to present perils: UHPLC-QqQ-MS/MS determination of methaqualone and its designer analogs (NPS) with comprehensive fragmentation pathways study (QTOF)	3
Protective effect of indomethacin on vanadium-induced adrenocortical and testicular damages in rat	3
Antihyperlipidemic effect of tyrosol, a phenolic compound in streptozotocin-induced diabetic rats	3
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling	3
Analytical and toxicological aspects of dithiocarbamates: an overview of the last 10 years	2
Differential effects of OATP2B1 on statin accumulation and toxicity in a beta cell model	2
Leveraging new approach methodologies: ecotoxicological modelling of endocrine disrupting chemicals to Danio rerio through machine learning and toxicity studies	2
Bidirectional role of reactive oxygen species during inflammasome activation in acrolein-induced human EAhy926 cells pyroptosis	2
Glycoprotein levels and oxidative lung injury in experimental diabetes: effect of oxovanadium(IV) complex based on thiosemicarbazone	2
The system of self-consistent models for pesticide toxicity to Daphnia magna	2
Exploring the impact of ambient air PM 2.5 on multiple sclerosis: an experimental dive into neuroinflammation	2
Propofol alleviates traumatic brain injury through regulating Th17/Treg balance by activation of the AMPK/SIRT1 pathway	2
Combination of oxytetracycline and quinocetone synergistically induces hepatotoxicity via generation of reactive oxygen species and activation of mitochondrial pathway	2
Neuroprotective effect of marrubiin against MPTP-induced experimental Parkinson’s disease in male wistar rats	2
Modification of the hemodynamic and molecular features of phosphine, a potent mitochondrial toxicant in the heart, by cannabidiol	2
Design of a microfluidic lung chip and its application in assessing the toxicity of formaldehyde	2
Serum α-SMA is a potential noninvasive biomarker of liver fibrosis	2
Detection of endocrine and metabolism disrupting xenobiotics in milk-derived fat samples by fluorescent protein-tagged nuclear receptors and live cell imaging	2
Obesity aggravates neuroinflammatory and neurodegenerative effects of bisphenol A in female rats	2
Mass spectrometric methods for evaluation of voriconazole avian pharmacokinetics and the inhibition of its cytochrome P450-induced metabolism	2

Mechanisms involved in the valproic acid-induced hepatotoxicity: a comprehensive review	2
Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity	2
Analysis of toxicity effects of delta-9-tetrahydrocannabinol on isolated rat heart mitochondria	2
Identification of miRNAs and target genes associated with lymph node metastasis in cervical cancer using bioinformatics analysis	2
Histological and biochemical investigation of the renoprotective effects of metformin in diabetic and prostate cancer model	2
Quantitative methods for the risk assessment of drinking water contact chemicals following the NSF/ANSI/CAN 600 standard – part I: general methods	2
A systematic review of preclinical studies on the taurine role during diabetic nephropathy: focused on anti-oxidative, anti-inflammation, and anti-apoptotic effects	2