Toxicology Mechanisms and Methods

Article	Citations
Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development	53
Modeling better in vitro models for the prediction of nanoparticle toxicity: a review	49
Automated lipid droplet quantification system for phenotypic analysis of adipocytes using CellProfiler	27
The implication of mitochondrial dysfunction and mitochondrial oxidative damage in di (2-ethylhexyl) phthalate induced nephrotoxicity in both in vivo and in vitro models	27
Treatment of oxidative stress, apoptosis, and DNA injury with N-acetylcysteine at simulative pesticide toxicity in fish	26
Cytotoxicity profiles of multi-walled carbon nanotubes with different physico-chemical properties	25
Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: impact on TGF-β/Smad3 and NF-κB signaling pathways	22
Protective effect of metformin against rotenone-induced parkinsonism in mice	22
Relevant essential oil components: a minireview on increasing applications and potential toxicity	21
Assesment of hematotoxic, oxidative and genotoxic damage potentials of fipronil in rainbow trout Oncorhynchus mykiss, Walbaum	17
Exosomes derived from bone marrow mesenchymal stem cells reverse epithelial-mesenchymal transition potentially via attenuating Wnt/β-catenin signaling to alleviate silica-induced pulmonary fibrosis	17
Phosgene: toxicology, animal models, and medical countermeasures	17
Neurotoxicity and related mechanisms of flame retardant TCEP exposure in mice	17
Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis	17
Investigation on photo-induced mechanistic activity of GO/TiO2 hybrid nanocomposite against wound pathogens	16
Underlying mechanisms of apoptosis in HepG2 cells induced by polyphyllin I through Fas death and mitochondrial pathways	16
Deferoxamine ameliorated Al(mal)3-induced neuronal ferroptosis in adult rats by chelating brain iron to attenuate oxidative damage	15
Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation	15
Royal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the nrf-2/NF-κB and bcl-2/bax pathway	15
Dexamethasone as an anti-cancer or hepatotoxic	14
Toxicity, preparation methods and applications of silver nanoparticles: an update	14
A comprehensive review of treatments for hydrogen sulfide poisoning: past, present, and future	13
The searching for agents for Alzheimer’s disease treatment via the system of self-consistent models	13
Effects of imidacloprid on viability and increase of reactive oxygen and nitrogen species in HepG2 cell line	13
Phosgene oxime: a highly toxic urticant and emerging chemical threat	13

Chronic exposure to multi-metals on testicular toxicity in rats	13
Effects of arsenic exposure on lipid metabolism: a systematic review and meta-analysis	13
Cilostazol protects against cyclophosphamide-induced ovarian toxicity in female rats: role of cAMP and HO-1	13
Combinative ex vivo studies and in silico models ProTox-II for investigating the toxicity of chemicals used mainly in cosmetic products	12
Aristolochic acid induces mitochondrial apoptosis through oxidative stress in rats, leading to liver damage	12
Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials	11
Aluminum maltolate triggers ferroptosis in neurons: mechanism of action	11
Curcumin reverses hepatic epithelial mesenchymal transition induced by trichloroethylene by inhibiting IL-6R/STAT3	11
Does low concentration mycotoxin exposure induce toxicity in HepG2 cells through oxidative stress?	10
Histological and biochemical investigation of the renoprotective effects of metformin in diabetic and prostate cancer model	10
Targeting macrophage polarization by Nrf2 agonists for treating various xenobiotics-induced toxic responses	9
Manganese-induced neurotoxicity and the potential protective effects of lipoic acid and Spirulina platensis	9
Attenuation of experimentally induced atopic dermatitis in mice by sulforaphane: effect on inflammation and apoptosis	9
Genotoxicity evaluation of silica nanoparticles in murine: a systematic review and meta-analysis	9
Effects of catechin hydrate in benzo[a]pyrene-induced lung toxicity: roles of oxidative stress, apoptosis, and DNA damage	9
Methyl palmitate reversed estradiol benzoate-induced endometrial hyperplasia in female rats	9
Development of chlorine-induced lung injury in the anesthetized, spontaneously breathing pig	9
Oxidative stress-mediated mitochondrial pathway-dependent apoptosis is induced by silica nanoparticles in H9c2 cardiomyocytes	9
Studying the ophthalmic toxicity potential of developed ketoconazole loaded nanoemulsion in situ gel formulation for ophthalmic administration	9
The role of levosimendan in phosphine-induced cardiotoxicity: evaluation of electrocardiographic, echocardiographic, and biochemical parameters	9
In vivoandin silicoevaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats	8
The use of combined high-fructose diet and glyphosate to model rats type 2 diabetes symptomatology	8
A systematic review of preclinical studies on the taurine role during diabetic nephropathy: focused on anti-oxidative, anti-inflammation, and anti-apoptotic effects	8
Ready to go 3D? A semi-automated protocol for microwell spheroid arrays to increase scalability and throughput of 3D cell culture testing	8
Nephro-protective activity of wheatgrass juice against alcohol-induced oxidative damage in rats	8
Transcriptome alterations and genotoxic influences in zebrafish larvae after exposure to dissolved aluminum and aluminum oxide nanoparticles	8
Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity	8
Prophylactic effect of probiotics fortified withAloe verapulp nanoemulsion against ethanol-induced gastric ulcer	8
The antioxidant study proprieties of Thymus munbyanus aqueous extract and its beneficial effect on 2, 4-Dichlorophenoxyacetic acid -induced hepatic oxidative stress in albino Wistar rats	8
Fluoride induced testicular toxicities in adult Wistar rats	8
Neonatal maternal separation causes decreased numbers of sertoli cell, spermatogenic cells, and sperm in mice	7
Induction of genotoxicity and differential alterations of p53 and inflammatory cytokines expression by acute oral exposure to bulk- or nano-calcium hydroxide particles in mice "Genotoxicity of norm	7
Conjugated linoleic acid protects brain mitochondrial function in acrolein induced male rats	7
Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling	7
Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and Parkin in Pb and β-amyloid peptide induced toxicity	7
Aflatoxin B1 inhibited autophagy flux by inducing lysosomal alkalinization in HepG2 cells	7
Predicting the mutagenic potential of chemicals in tobacco products using in silico toxicology tools	7
AK-1, a Sirt2 inhibitor, alleviates carbon tetrachloride-induced hepatotoxicity in vivo and in vitro	6
Review of data on chemical content in an aerosol resulting from heating a tobacco or a solution used in e-cigarettes and in the smoke generated from the reference cigarettes	6
Bidirectional role of reactive oxygen species during inflammasome activation in acrolein-induced human EAhy926 cells pyroptosis	6
Modification of the hemodynamic and molecular features of phosphine, a potent mitochondrial toxicant in the heart, by cannabidiol	6
‘Ideal correlations’ for the predictive toxicity to Tetrahymena pyriformis	6
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damag	6
MiR-191 downregulation protects against isoflurane-induced neurotoxicity through targeting BDNF	6
Cardioprotective effects of corilagin on doxorubicin induced cardiotoxicity via P13K/Akt and NF-κB signaling pathways in a rat model	6
Potential protective effect of catechin on doxorubicin-induced cardiotoxicity in adult male albino rats	6
In vitro effect of DDE exposure on the regulation of B-TC-6 pancreatic beta cell insulin secretion: a potential role in beta cell dysfunction and type 2 diabetes mellitus	6
Nano-CuO causes cell damage through activation of dose-dependent autophagy and mitochondrial lncCyt b-AS/ND5-AS/ND6-AS in SH-SY5Y cells	6
Cardioprotective effect of allyl isothiocyanate in a rat model of doxorubicin acute toxicity	6
Dexmedetomidine provides protection to neurons against OGD/R-induced oxidative stress and neuronal apoptosis	6

Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats	6
Cytotoxicity, oxidative stress, and inflammatory response of smokeless tobacco extracts and cytotoxicity of combustible cigarette whole smoke in a 3D oral organotypic buccal cell model	6
Halogen gas exposure: toxic effects on the parturient	6
New Multi-Walled carbon nanotube of industrial interest induce cell death in murine fibroblast cells	5
Sterigmatocystin-induced DNA damage triggers cell-cycle arrest via MAPK in human neuroblastoma cells	5
Exposure of calcium carbide induces apoptosis in mammalian fibroblast L929 cells	5
Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease	5
Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma	5
Neuroprotective effect of Morin via TrkB/Akt pathway against diabetes mediated oxidative stress and apoptosis in neuronal cells	5
Neuroprotective effect of miR-212-5p on isoflurane-induced cognitive dysfunction by inhibiting neuroinflammation	5
Effects of smokeless tobacco on cell viability, reactive oxygen species, apoptosis, and inflammatory cytokines in human umbilical vein endothelial cells	5
Comparison of the effect of vitamin C and selenium nanoparticles on gentamicin-induced renal impairment in male rats: a biochemical, molecular and histological study	5
Comparative outcomes of exposing human liver and kidney cell lines to tungstate and molybdate	5
Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver	4
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis	4
Analysis of cytotoxicity and genotoxicity in a short-term dependent manner induced by a new titanium dioxide nanoparticle in murine fibroblast cells	4
N-acetylcysteine ameliorates monocrotophos exposure-induced mitochondrial dysfunctions in rat liver	4
Comparative effects of galactose-induced aging on mitochondrial permeability transition in rat liver and testis	4
Naringenin alleviates hepatic injury in zinc oxide nanoparticles exposed rats: impact on oxido-inflammatory stress and apoptotic cell death	4
Vitamin B12 alleviates malathion-induced toxicity in zebra fish by regulating cytochrome P450 and PgP expressions	4
Fluoride effects on cell viability and ENaC expression in kidney epithelial cells	4
Evaluating the protective role of Deglycyrrhizinated licorice root supplement on bleomycin induced pulmonary oxidative damage	4
Evaluation of doxorubicin-induced early multi-organ toxicity in male CD1 mice by biodistribution of18F-FDG and67Ga-citrate. Pilot study	4
Schisandrin A alleviates mycophenolic acid-induced intestinal toxicity by regulating cell apoptosis and oxidative damage	4
Identification of differentially expressed genes and pathways in diquat and paraquat poisoning using bioinformatics analysis	4
Triflumuron induces genotoxicity in both mice bone marrow cells and human Colon cancer cell line	4
Combination of oxytetracycline and quinocetone synergistically induces hepatotoxicity via generation of reactive oxygen species and activation of mitochondrial pathway	4
Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p	4
Antihyperlipidemic effect of tyrosol, a phenolic compound in streptozotocin-induced diabetic rats	4
Combine colorants of tartrazine and erythrosine induce kidney injury: involvement of TNF-α gene, caspase-9 and KIM-1 gene expression and kidney functions indices	4
Grape seed extract proanthocyanidin antagonizes aristolochic acid I-induced liver injury in rats by activating PI3K-AKT pathway	4
Markers involved in proinflammatory effects by environmental toxicants	4
Toxicological analyses: analytical method validation for prevention or diagnosis	4
Paraben concentrations found in human body fluids do not exert steroidogenic effects in human granulosa primary cell cultures	4
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling	4
The 2-year rodent bioassay in drug and chemical carcinogenesis testing: Sensitivity, according to the framework of carcinogenic action	4
Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids	3
Genotoxicity mechanism of food preservative propionic acid in the in vivo Drosophila model: gut damage, oxidative stress, cellular immune response and DNA damage	3
Malignancy and tumorigenicity of melanoma B16 cells are not affected by silver and gold nanoparticles	3
Downregulation of Acat1 by miR-21 may participate in liver fibrosis upon chronic DDT exposure	3
Neuroprotective potential of trimetazidine against tramadol-induced neurotoxicity: role of PI3K/Akt/mTOR signaling pathways	3
Implications for herbal polypharmacy: coumarin-induced hepatotoxicity increased through common herbal phytochemicals astragaloside IV and atractylenolide I	3
The protective role of Nrf2 against aristolochic acid-induced renal tubular epithelial cell injury	3
Isoflurane alleviates hypoxia/reoxygenation induced myocardial injury by reducing miR-744 mediated SIRT6	3
Interaction of quercetin and 5-fluorouracil: cellular and pharmacokinetic study	3
Safety assessment of a novel water-soluble extract of Boswellia serrata gum resin: acute toxicity, 90-day sub-chronic toxicity, Ames’ bacterial reverse mutation, and in vivo micronucleus	3
Bone marrow mononuclear cells boosts anti-cytogentical aberration effect of N-acetylcysteine and α-lipoic acid in rat’s liver and bone marrow: implication of oxidative and inflammatory pathways	3
Exploration of the cellular effects of the high-dose, long-term exposure to coffee roasting product furan and its by-product cis-2-butene-1,4-dial on human and rat hepatocytes	3
Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis	3
Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin	3
Hematotoxic, oxidative and genotoxic damage in rainbow trout (Oncorhynchus mykiss) after exposure to 3-benzoylpyridine	3
The effects of prenatal and lactational bisphenol A and/or di(2-ethylhexyl) phthalate exposure on female reproductive system	3
Menthol additives to tobacco products. Reasons for withdrawing mentholated cigarettes in European Union on 20th may 2020 according to tobacco products directive (2014/40/EU)	3
Glycoprotein levels and oxidative lung injury in experimental diabetes: effect of oxovanadium(IV) complex based on thiosemicarbazone	3
Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice – a comparison with oxime-based treatment	3
Enhancing global and local decision making for chemical safety assessments through increasing the availability of data	3
Analysis of toxicity effects of delta-9-tetrahydrocannabinol on isolated rat heart mitochondria	3
Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats	3
Acute and sub-acute toxicity study reveals no dentrimental effect of formononetin in mice upon repeated i.p. dosing	3
A novel anticancer chromeno-pyrimidine analogue inhibits epithelial-mesenchymal transition in lung adenocarcinoma cells	3
Evaluation of Calu-3 cell lines as an in vitro model to study the inhalation toxicity of flavoring extracts	3
Molecular interactions of vinclozolin metabolites with human estrogen receptors 1GWR-α and 1QKM and androgen receptor 2AM9-β: Implication for endocrine disruption	3
Effects of bisphenol A and S on blood coagulation: in vivo, in vitro and in silico approaches in toxicodynamic	3
The involvement of Nrf2/HO-1/cytoglobin and Ang-II/NF-κB signals in the cardioprotective mechanism of lansoprazole against cisplatin-induced heart injury	3
Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells	3
Acute promyelocytic leukemia drug – arsenic trioxide in the presence of eugenol shows differential action on leukemia cells (HL-60) and cardiomyocytes (H9c2) – inference from NMR study	3
Crotonaldehyde exposure induces liver dysfunction and mitochondrial energy metabolism disorder in rats	3
The Strategic National Stockpile: identification, support, and acquisition of medical countermeasures for CBRN incidents	3
Methylglyoxal disturbs DNA repair and glyoxalase I system in Saccharomyces cerevisiae	3
Degradation of phosalone by silver ion catalytic hydrolysis	2
An in vitro human assay for evaluating immunogenic and sensitization potential of a personal care and cosmetic product	2
Predictable hematological markers associated with cognitive decline in valid rodent models of cognitive impairment	2
Neuroprotective effect of Bryophyllum pinnatum flavonoids against aluminum chloride-induced neurotoxicity in rats	2
Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-κB/TLR4 signals	2
An integrated in silico and in vivo approach to determine the effects of three commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate on	2
Fermented whey modulated AFB1 and OTA-induced hepatotoxicity and nephrotoxicity in vivo. A relative and absolute quantification about sex differences	2
Rotenone induces hepatotoxicity in rats by activating the mitochondrial pathway of apoptosis	2
Molecular signatures associated with diuron exposure on rat urothelial mitochondria	2
Myocardial infarction and oxidative damage in animal models: objective and expectations from the application of cysteine derivatives	2
The STING-IRF3 pathway contributes to paraquat-induced acute lung injury	2

Toxicology of long‐term and high-dose administration of methylphenidate on the kidney tissue – a histopathology and molecular study	2
Toxicity effects evaluation of green synthesized silver nanoparticles on intraperitoneally exposed male Wistar rats	2
Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236	2
The absence of genotoxicity of a mixture of aloin A and B and a commercial aloe gel beverage	2
The changes of MRP2 expression in three kinds of pulmonary inflammation models: the downregulation occurred in cigarette smoke extract (CSE) stimulation group and CSE plus LPS stimulation group, uncha	2
Application of three-dimensional Raman imaging to determination of the relationship between cellular localization of diesel exhaust particles and the toxicity	2
Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by activating DGAT1-dependent biogenesis and inhibiting PGC1ɑ-dependent fat catabolism in immortalized human bronchial epithel	2
Special issue: emerging chemical terrorism threats	2
Autophagy up-regulated by MEK/ERK promotes the repair of DNA damage caused by aflatoxin B1	2
4,4′-Diisothiocyanatostilbene-2,2′-disulfonate modulates voltage-gated K+ current and influences cell cycle arrest in androgen sensitive and insensitive human prostate cancer cell lines	2
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model	2
Liquid chromatography/tandem mass spectrometric analysis of penicillamine for its pharmacokinetic evaluation in dogs	2
Estimation of mandarin peel oil–induced cytotoxicity and genotoxicity in human normal fibroblast and cancerous prostate cell lines	2
Lasso-Logistic regression model for the identification of serum biomarkers of neurotoxicity induced by strychnos alkaloids	2
Integrating network pharmacology and in vitro model to investigate hippocampal neurotoxicity induced by atrazine	2
Balancing renal Ang-II/Ang-(1–7) by xanthenone; an ACE2 activator; contributes to the attenuation of Ang-II/p38 MAPK/NF-κB p65 and Bax/caspase-3 pathways in amphotericin B-induced nephrotoxicity in ra	2
Antioxidant thymoquinone and eugenol alleviate TiO2 nanoparticle-induced toxicity in human blood cells in vitro	2
Ramelteon and mechanism of its restorative effect in an experimental lung disease model	2
Chebulagic acid attenuates HFD/streptozotocin induced impaired glucose metabolism and insulin resistance via up regulations of PPAR γ and GLUT 4 in type 2 diabetic rats	2
miR-26a-5p protects against drug-induced liver injury via targeting bid	2
Development of reliable quantitative structure–toxicity relationship models for toxicity prediction of benzene derivatives using semiempirical descriptors	2
The mechanism of miR-363-3p/DUSP10 signaling pathway involved in the gastric mucosal injury induced by clopidogrel	2