OOIR: Observatory of International Research

Papers

(The TQCC of Vascular Pharmacology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Endothelial dysfunction in acute and long standing COVID−19: A prospective cohort study	78
Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage	74
Extracellular vesicles and cardiovascular system: Biomarkers and Cardioprotective Effectors	69
SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells	64
Endothelial cells and SARS-CoV-2: An intimate relationship	51
RAAS inhibitors are not associated with mortality in COVID-19 patients: Findings from an observational multicenter study in Italy and a meta-analysis of 19 studies	34
Venous thromboembolism in COVID-19 compared to non-COVID-19 cohorts: A systematic review with meta-analysis	33
Perivascular adipose-derived exosomes reduce macrophage foam cell formation through miR-382-5p and the BMP4-PPARγ-ABCA1/ABCG1 pathways	31
Nectin-4 promotes lymphangiogenesis and lymphatic metastasis in breast cancer by regulating CXCR4-LYVE-1 axis	29
Interleukin-6 level is a powerful predictor of long-term cardiovascular mortality in patients with acute coronary syndrome	28
Circular RNA circ_0029589 regulates proliferation, migration, invasion, and apoptosis in ox-LDL-stimulated VSMCs by regulating miR-424-5p/IGF2 axis	26
The short-chain fatty acid butyrate accelerates vascular calcification via regulation of histone deacetylases and NF-κB signaling	22
A possible role for ST2 as prognostic biomarker for COVID-19	22
A new storm on the horizon in COVID-19: Bradykinin-induced vascular complications	22
Angiotensin-II activates vascular inflammasome and induces vascular damage	20
Diabetic neuropathy: Molecular approach a treatment opportunity	20
Factor Xa inhibitor rivaroxaban suppresses experimental abdominal aortic aneurysm progression via attenuating aortic inflammation	19
Therapeutic potential of flavonoids in the treatment of chronic venous insufficiency	19
Extracellular vesicles (EVs) in ischemic conditioning and angiogenesis: Focus on endothelial derived EVs	19
Exosomal miR-211 contributes to pulmonary hypertension via attenuating CaMK1/PPAR-γaxis	18
Exercise-induced pulmonary hypertension in HFpEF and HFrEF: Different pathophysiologic mechanism behind similar functional impairment	18
Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients	17
Effects of statins in primary and secondary prevention for venous thromboembolism events: A meta analysis	16
Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration	16
Tissue optical clearing for 3D visualization of vascular networks: A review	16

Risk stratification of patients with SARS-CoV-2 by tissue factor expression in circulating extracellular vesicles	16
Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes	16
Effect of high-dose statin therapy on coagulation factors: Lowering of factor XI as a modifier of fibrin clot properties in coronary artery disease	15
Exploring the regulatory roles of circular RNAs in the pathogenesis of atherosclerosis	15
Sodium-glucose cotransporter type 2 inhibitors prevent ponatinib-induced endothelial senescence and disfunction: A potential rescue strategy	15
MCU-dependent mitochondrial calcium uptake-induced mitophagy contributes to apelin-13-stimulated VSMCs proliferation	15
Empagliflozin prevents angiotensin II-induced hypertension related micro and macrovascular endothelial cell activation and diastolic dysfunction in rats despite persistent hypertension: Role of endoth	15
Extracellular vesicle-mediated miR135a-5p transfer in hypertensive rat contributes to vascular smooth muscle cell proliferation via targeting FNDC5	15
Transcriptional regulation of vascular smooth muscle cell proliferation, differentiation and senescence: Novel targets for therapy	14
Transplantation of telomerase/myocardin-co-expressing mesenchymal cells in the mouse promotes myocardial revascularization and tissue repair	14
Circ_0004872 promotes platelet-derived growth factor-BB-induced proliferation, migration and dedifferentiation in HA-VSMCs via miR-513a-5p/TXNIP axis	14
Assessment of ACE1 variants and ACE1/ACE2 expression in COVID-19 patients	13
Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cells	13
Increased histone-DNA complexes and endothelial-dependent thrombin generation in severe COVID-19	13
The impact of proangiogenic microRNA modulation on blood flow recovery following hind limb ischemia. A systematic review and meta-analysis of animal studies	12
Treatment with PCSK9 inhibitors induces a more anti-atherogenic HDL lipid profile in patients at high cardiovascular risk	12
The lncRNA MALAT1 participates in regulating coronary slow flow endothelial dysfunction through the miR-181b-5p–MEF2A–ET-1 axis	12
Intensive low-density lipoprotein cholesterol lowering improves fibrin clot properties: Association with lipoproteins and C-reactive protein	11
Targeting endothelial ion signalling to rescue cerebral blood flow in cerebral disorders	11
Extrinsic and intrinsic factors influencing metabolic memory in type 2 diabetes	11
Septic shock as a trigger of arterial stress-induced premature senescence: A new pathway involved in the post sepsis long-term cardiovascular complications	11
Inhibition on CXCL5 reduces aortic matrix metalloproteinase 9 expression and protects against acute aortic dissection	11
Pravastatin plus L-arginine prevents adverse pregnancy outcomes in women with uteroplacental vascular dysfunction	10
Tetrandrine promotes angiogenesis via transcriptional regulation of VEGF-A	10
High density lipoprotein in atherosclerosis and coronary heart disease: Where do we stand today?	10
The effect of the 2019 ESC/EAS dyslipidaemia guidelines on low-density lipoprotein cholesterol goal achievement in patients with acute coronary syndromes: The ACS EuroPath IV project	10
Ischemic heart disease and cardioprotection: Focus on estrogenic hormonal setting and microvascular health	10
Neuropeptide Y facilitates P2X1 receptor-dependent vasoconstriction via Y1 receptor activation in small mesenteric arteries during sympathetic neurogenic responses	10
In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity	10
Targeting residual inflammatory risk: The next frontier for atherosclerosis treatment and prevention	10
Osteogenic differentiation and calcification of human aortic smooth muscle cells is induced by the RCN2/STAT3/miR-155-5p feedback loop	9
Vildagliptin improves vascular smooth muscle relaxation and decreases cellular senescence in the aorta of doxorubicin-treated rats	9
Challenges facing the clinical translation of cardioprotection: 35 years after the discovery of ischemic preconditioning	9
CircDIP2C ameliorates oxidized low-density lipoprotein-induced cell dysfunction by binding to miR-556-5p to induce TET2 in human umbilical vein endothelial cells	9
Beneficial effects of melatonin on prostanoids pathways in pulmonary hypertensive neonates	9
Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats	9
Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability	8
The lncRNA PAHRF functions as a competing endogenous RNA to regulate MST1 expression by sponging miR-23a-3p in pulmonary arterial hypertension	8
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, attenuates apoptosis of vascular smooth muscle cells and reduces atherosclerosis in diabetic apolipoprotein E–deficient mice	8
Chronic cyclooxygenase-2 inhibition prevents the worsening of hypertension and endothelial dysfunction induced by ouabain in resistance arteries of spontaneously hypertensive rats	8
The potential role of thymoquinone in preventing the cardiovascular complications of COVID-19	8
Inducible degrader of LDLR: A potential novel therapeutic target and emerging treatment for hyperlipidemia	8
Optimal duration and combination of antiplatelet therapies following percutaneous coronary intervention: a meta-analysis	8
Stimulation of angiotensin II receptor 2 preserves cognitive function and is associated with an enhanced cerebral vascular density after stroke	8
Optical excitation of organic semiconductors as a highly selective strategy to induce vascular regeneration and tissue repair	8
Benefits with drug-coated balloon as compared to a conventional revascularization strategy for the treatment of coronary and non-coronary arterial disease: a comprehensive meta-analysis of 45 randomiz	7
Eighty years of oral anticoagulation: Learning from history	7
Inflammation and the pathogenesis of atherosclerosis	7
Soluble epoxide hydrolase inhibitor, TPPU, attenuates progression of atherosclerotic lesions and vascular smooth muscle cell phenotypic switching	7
Comparative bioavailability of inhaled treprostinil administered as LIQ861 and Tyvaso® in healthy subjects	7

Crosstalk of TLR4, vascular NADPH oxidase, and COVID-19 in diabetes: What are the potential implications?	7
Late phase endothelial cell inflammation is characterized by interferon response genes and driven by JAK/STAT, not NFκB	7
Ozagrel a thromboxane A2 synthase inhibitor extenuates endothelial dysfunction, oxidative stress and neuroinflammation in rat model of bilateral common carotid artery occlusion induced vascular dement	7
SGLT2-i prevent left ventricular dysfunction induced by anthracycline in mouse model: A systematic-review and meta-analysis	7
Long-term dietary n3 fatty acid prevents aging-related cardiac diastolic and vascular dysfunction	7
The close link between brain vascular pathological conditions and neurodegenerative diseases: Focus on some examples and potential treatments	7
Β-blockers activate autophagy on infantile hemangioma-derived endothelial cells in vitro	7
Thromboprophylaxis strategies to improve the prognosis of COVID-19	7
Vitamin D deficiency is associated with impaired reperfusion in STEMI patients undergoing primary percutaneous coronary intervention	6
Glucocorticoid induced TNF receptor family-related protein (GITR) – A novel driver of atherosclerosis	6
Pulmonary pressure recovery in idiopathic, hereditary and drug and toxin-induced pulmonary arterial hypertension: determinants and clinical impact	6
Exploring the mechanisms of action of gliflozines in heart failure and possible implications in pulmonary hypertension	6
COMP-Ang1: Therapeutic potential of an engineered Angiopoietin-1 variant	6
Insights into elastic fiber fragmentation: Mechanisms and treatment of aortic aneurysm in Marfan syndrome	6
Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension	6
G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation	6
Residual platelet reactivity in low-dose aspirin-treated patients with class 1 obesity	6
Angiocrine endothelium: From physiology to atherosclerosis and cardiac repair	6
Kidney endothelial cell heterogeneity, angiocrine activity and paracrine regulatory mechanisms	5
Anticoagulation therapy in patients with post-operative atrial fibrillation: Systematic review with meta-analysis	5
Insulin-treated versus noninsulin-treated diabetes and risk of ischemic stroke in patients with atrial fibrillation	5
Melatonin treatment during chronic hypoxic gestation improves neonatal cerebrovascular function	5
TLR4-Myd88 pathway upregulated caveolin-1 expression contributes to coronary artery spasm	5
Aging, sex and NLRP3 inflammasome in cardiac ischaemic disease	5
Influence of long-term proteasome inhibition on platelet responsiveness mediated by bortezomib	5
Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification	5
TPN171H alleviates pulmonary hypertension via inhibiting inflammation in hypoxia and monocrotaline-induced rats	5
Losartan metabolite EXP3179 is a unique blood pressure-lowering AT1R antagonist with direct, rapid endothelium-dependent vasoactive properties	5
Ticagrelor inhibits platelet aggregation and reduces inflammatory burden more than clopidogrel in patients with stages 4 or 5 chronic kidney disease	5
Immune responses against oxidized LDL as possible targets for prevention of atherosclerosis in systemic lupus erythematosus	5
Ticagrelor as compared to conventional antiplatelet agents in coronary artery disease: A comprehensive meta-analysis of 15 randomized trials	4
Sdox, a H2S releasing anthracycline, with a safer profile than doxorubicin toward vasculature	4
The impacts of endogenous progesterone and exogenous progestin on vascular endothelial cell, and smooth muscle cell function: A narrative review	4
Endovascular thrombectomy with or without intravenous thrombolysis in large-vessel ischemic stroke: A non-inferiority meta-analysis of 6 randomised controlled trials	4
Endothelial leptin receptor is dispensable for leptin-induced sympatho-activation and hypertension in male mice	4
Endothelial TrkB receptor activation controls vascular tone of rat middle cerebral artery	4
Exercise-induced pulmonary hypertension in HIV patients: Association with poor clinical and immunological status	4
Prolonged impact of anti-cancer therapy on endothelial function and arterial stiffness in breast cancer patients	4
Platelet apelin receptor expression is reduced in patients with acute myocardial infarction	4
A review of genetically-driven rodent models of pulmonary hypertension	4
Beta-blockers in pulmonary arterial hypertension: Time for a second thought?	4
NAD+ attenuates cardiac injury after myocardial infarction in diabetic mice through regulating alternative splicing of VEGF in macrophages	4
Porto-pulmonary arterial hypertension: Translation of pathophysiological concepts to the bedside	4
Sphingosine 1-phosphate-induced nitric oxide production simultaneously controls endothelial barrier function and vascular tone in resistance arteries	4
The effect of dihydroceramide desaturase 1 inhibition on endothelial impairment induced by indoxyl sulfate	4
Potency of miR-144-3p in promoting abdominal aortic aneurysm progression in mice correlates with apoptosis of smooth muscle cells	4
Molecular and cellular effects of in vivo chronic intravascular hemolysis and anti-inflammatory therapeutic approaches	4
Flow Mediated Dilation in Systemic Sclerosis: Association with clinical findings, capillaroscopic patterns and endothelial circulating markers	4
CRH/CRHR1 modulates cerebrovascular endothelial cell permeability in association with S1PR2 and S1PR3 under oxidative stress	4
Berberine inhibits osteogenic differentiation of aortic valve interstitial cells by interfering Smad1/5/8 and NF-κB pathways	4
Hinokitiol produces vasodilation in aortae from normal and angiotensin II- induced hypertensive rats via endothelial-dependent and independent pathways	4
Pathophysiology of coronary microvascular dysfunction	4
Empagliflozin decreases ageing-associated arterial stiffening and vascular fibrosis under normoglycemic conditions	4