Cancer Cell

Article	Citations
Accelerated approvals: Early-phase success or premature authorization?	2132
Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton	600
KIT as a therapeutic target in neuroendocrine prostate cancer	577
TAMing immunity through an unexpected source	537
Characterization of the generic mutant p53-rescue compounds in a broad range of assays	414
A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture	406
Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer	405
KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition	368
Dynamic circulating tumor DNA during chemoradiotherapy predicts clinical outcomes for locally advanced non-small cell lung cancer patients	353
Long-range cholinergic input promotes glioblastoma progression	351
Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer	341
Diet-microbiome interactions in cancer	335
Lymphoma accelerates T cell and tissue aging	298
EGFR-activated myofibroblasts promote metastasis of pancreatic cancer	294
Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations	288
Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling	285
Spatial profiling technologies illuminate the tumor microenvironment	264
Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas	264
Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer	256
T cell dynamism and immune-related adverse events	252
Enhanced SARS-CoV-2 breakthrough infections in patients with hematologic and solid cancers due to Omicron	246
Elucidating acquired PARP inhibitor resistance in advanced prostate cancer	245
The aging lung microenvironment awakens melanoma metastases	244
Cancer vaccines	242
Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses	241

Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion	237
Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma	236
Bacteria in metastatic sites: Unveiling hidden players in cancer progression	236
B cell heterogeneity in cancer comes of age	226
Neutralization breadth of SARS-CoV-2 viral variants following primary series and booster SARS-CoV-2 vaccines in patients with cancer	220
T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation	219
A holistic view of cancer	218
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target	217
Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer	217
Challenges in neoantigen-directed therapeutics	213
High endothelial venules in cancer: Regulation, function, and therapeutic implication	211
Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer	211
Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin	208
Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity	200
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer	199
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer	198
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments	196
Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors	196
Gut microbes promote chemoradiotherapy resistance via metabolic cross-feeding	195
Immunosensitivity cuts across mismatch repair status in colorectal cancer	193
Tumor-directed dysregulation of erythroid progenitors drives immunosuppressive myeloid cells	193
Are we ready to look beyond plasma cells in assessing high-risk smoldering myeloma?	188
A genetic portrait of metastatic seeds in lung adenocarcinoma	185
Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts	183
Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer	179
Tumor organoid-originated biomarkers predict immune response to PD-1 blockade	177
Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation	177
Revisiting TNM staging for EBV-related nasopharyngeal carcinoma	176
The one-two punch: TIM-3 blockade targets immune and tumor cells to knock out pediatric brain tumors	172
Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy	164
Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma	164
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression	163
Challenges and opportunities for modeling aging and cancer	161
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer	160
Prior anti-CTLA-4 therapy impacts molecular characteristics associated with anti-PD-1 response in advanced melanoma	156
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification	154
Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation	153
Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients	149
Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma	149
Hypoxia inducible factor-1α drives cancer resistance to cuproptosis	147
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer	144
Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy	144
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity	143
Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population	141
Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics	140
Response-based molecular subtyping—emergence of the third generation of breast cancer subtypes	139
Dissecting bulk transcriptomes of diffuse large B cell lymphoma	139
Hepatobiliary tumor organoids for personalized medicine: a multicenter view on establishment, limitations, and future directions	138
A path to translation: How 3D patient tumor avatars enable next generation precision oncology	138
Recognition of observer effect is required for rigor and reproducibility of preclinical animal studies	137

ILC3 plasticity in microbiome-mediated tumor progression and immunotherapy	136
Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma	135
Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1	135
Immune determinants of the pre-metastatic niche	133
Integrated proteogenomic characterization of glioblastoma evolution	131
Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers	130
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness	130
Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells	129
Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment	126
The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma	125
Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD	124
Midkine as a driver of age-related changes and increase in mammary tumorigenesis	121
Tumor-infiltrating lymphocytes: A new hope	120
MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells	120
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring	118
Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis	117
Risk factors for poor humoral response to primary and booster SARS-CoV-2 vaccination in hematologic and oncological outpatients—COVIDOUT study	117
Taxanes directly induce T cell cytotoxic extracellular vesicles to eradicate tumor cells	116
GDF15 research from bench to bedside	116
Tumors on different wavelengths	115
Firing up neutrophil anti-tumor immunity with cocktails	113
The winner takes it all: Competition drives clonal selection in gliomagenesis	111
A circular RNA in neuroendocrine carcinomas	110
Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma	109
CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma	108
JUPITER-06 establishes immune checkpoint inhibitors as essential first-line drugs for the treatment of advanced esophageal squamous cell carcinoma	108
Precise patient stratification in esophageal cancer: Biomarkers for immunochemotherapy	108
T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to squamous cancers	107
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma	107
Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma	106
Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer	106
Distinct spatiotemporal dynamics of CD8+ T cell-derived cytokines in the tumor microenvironment	106
New horizons at the interface of artificial intelligence and translational cancer research	105
Effect of neoadjuvant chemoradiotherapy with or without PD-1 antibody sintilimab in pMMR locally advanced rectal cancer: A randomized clinical trial	105
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance	105
Proteogenomic data and resources for pan-cancer analysis	104
Enhanced but variant-dependent serological and cellular immune responses to third-dose BNT162b2 vaccination in patients with multiple myeloma	104
Integrated single cell analysis reveals co-evolution of malignant B cells and tumor micro-environment in transformed follicular lymphoma	104
Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models	103
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer	102
GD2-CAR T cells in patients with osteosarcoma and neuroblastoma—it’s not only the T cells that matter	102
Lactobacillus reuteri—an old acquaintance takes on a new task in colorectal tumor surveillance	101
Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures	101
Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer	100
KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer	100
Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia	99
Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers	97
An immunogenic and oncogenic feature-based classification for chemotherapy plus PD-1 blockade in advanced esophageal squamous cell carcinoma	94
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4	93
Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer	90
PD-1 blockade is a promising therapeutic addition to neoadjuvant chemoradiation in locally advanced rectal cancer	89
From intestinal metaplasia to gastric cancer: Witnessing the rise of evil over time and space	89
Engineering myeloid cells for cancer immunotherapy	89
Stromal barriers to the abscopal effect	87
Plasma cell and cancer stem cell crosstalk in glioblastoma	87
Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis	85
High-frequency temperature monitoring for early detection of febrile adverse events in patients with cancer	85
Seed or soil: Tracing the immune subsets in metastatic tumors	85
Getting a handle on KRAS inhibitor resistance with hapten-mediated anti-tumor immunity	85
Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers	84
Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity	84
Stromal lipid species dictate melanoma metastasis and tropism	84
Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy	83
Bacteria and fungi: The counteracting modulators of immune responses to radiation therapy in cancer	83
Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy	82
Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance	82
Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow	81
Tumor microbiome links cellular programs and immunity in pancreatic cancer	80
High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer	80
Phenotypic signatures of circulating neoantigen-reactive CD8+ T cells in patients with metastatic cancers	79
The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells	78
Architecture sets the path: Breast cancer subtypes differently shape the early brain metastatic niche	78
When immunotherapy meets surgery in non-small cell lung cancer	77
Vascular characterization reveals immunomodulatory targets for brain metastases	77
The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative	75
Identification of specific PP2A complexes involved in human cell transformation	74
Combining personalized neoantigen vaccination with chemotherapy and anti-PD-1 to treat NSCLC	73
Nivolumab combined with induction chemotherapy and radiotherapy in nasopharyngeal carcinoma: A multicenter phase 2 PLATINUM trial	72
Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression	72
Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition	72

Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer	71
Increased antibody titers and reduced seronegativity following fourth mRNA COVID-19 vaccination in patients with cancer	70
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice	70
Comprehensive tumor-immune profiling reveals mediators of paradoxical immune sensitivity in sarcomatoid renal cell carcinoma	69
Subclonal immune evasion in non-small cell lung cancer	69
Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors	69
A first-in-class EGFR-directed KRAS G12V selective inhibitor	69
When essential metal elements become culprits—Cuproptosis in focus	69
Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding	68
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site	68
TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak	66
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma	66
Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity	66
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer	65
Bridging the gap: The future of cancer research and clinical oncology in Cancer Cell	65
Genomic mapping of metastatic organotropism in lung adenocarcinoma	65
Sex and cancer immunotherapy: Current understanding and challenges	64
IL-6 blockade in cancer patients treated with immune checkpoint blockade: A win-win strategy	64
Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition	64
The liver as a cytokine factory working on mRNA blueprints for cancer immunotherapy	64
Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade	63
Immune memory shapes ovarian cancer recurrence	62
Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance	62
Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer	62
A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression	62
Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread	60
Neutrophil-activating therapy for the treatment of cancer	60
Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma	60
A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma	59
Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice	59
Immune phenotypic linkage between colorectal cancer and liver metastasis	57
Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment	57
T cell engagers in solid tumors kick the door down	57
Rethinking relief: Targeting sensory neurons to combat cancer and pain	56
Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors	56
Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis	55
IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment	55
Senescent alveolar macrophages promote early-stage lung tumorigenesis	55
Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts	55
A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis	55
Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma	55
Cooperative CAR targeting to selectively eliminate AML and minimize escape	55
Metabolic regulation of Cathepsin B in tumor macrophages drives their pro-metastatic function	55
Tislelizumab plus chemotherapy as first-line treatment for recurrent or metastatic nasopharyngeal cancer: A multicenter phase 3 trial (RATIONALE-309)	54
A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers	54
Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer	54
Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity	53
TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory	53
The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells	53