Cancer Cell

Papers
(The TQCC of Cancer Cell is 48. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-02-01 to 2024-02-01.)
ArticleCitations
Oxidative Stress in Cancer1119
m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer618
A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications551
Conserved pan-cancer microenvironment subtypes predict response to immunotherapy450
Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance442
The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker438
Acquired Resistance to Immune Checkpoint Inhibitors409
Overcoming Endocrine Resistance in Breast Cancer379
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities375
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion358
Engineering CAR-T Cells for Next-Generation Cancer Therapy312
Proteogenomic and metabolomic characterization of human glioblastoma293
The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes279
Clinical Challenges of Immune Checkpoint Inhibitors270
Seroconversion rates following COVID-19 vaccination among patients with cancer264
Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer253
Challenges and Opportunities for Pancreatic Cancer Immunotherapy252
Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer248
Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade248
Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma244
MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate243
Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer240
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments236
Targeting the MAPK Pathway in KRAS-Driven Tumors234
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma232
Response and Resistance to BCR-ABL1-Targeted Therapies229
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth229
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation226
Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas224
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4222
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma218
Antibody response to SARS-CoV-2 vaccines in patients with hematologic malignancies213
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer212
Liquid Biopsy-Based Biomarkers of Treatment Response and Resistance209
Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial207
Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells197
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution196
Targeting cell-cycle machinery in cancer188
YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis187
Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition185
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma183
SARS-CoV-2 Viral Load Predicts Mortality in Patients with and without Cancer Who Are Hospitalized with COVID-19183
Microbiome and cancer182
COVID-19 and Cancer: Current Challenges and Perspectives181
Immunogenicity of SARS-CoV-2 messenger RNA vaccines in patients with cancer181
Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors177
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma174
Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer169
Advancing Cancer Research and Medicine with Single-Cell Genomics169
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy167
Immunometabolic Interplay in the Tumor Microenvironment167
Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple myeloma165
Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver163
Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer156
Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states155
Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial154
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma149
Biomolecular Condensates and Cancer148
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer145
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade145
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity145
Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer143
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification143
The Glioma Stem Cell Model in the Era of Single-Cell Genomics142
Mutant p53 suppresses innate immune signaling to promote tumorigenesis141
DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity140
Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL140
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer139
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations138
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma133
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer133
IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis133
Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer132
KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer131
Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells129
Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma129
Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma129
Integrated Omics of Metastatic Colorectal Cancer128
Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer128
Immunomodulation by targeted anticancer agents125
Artificial intelligence for clinical oncology124
An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence124
Antibody and T cell immune responses following mRNA COVID-19 vaccination in patients with cancer122
ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis120
Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II/III breast cancer: Results from the adaptively randomized I-SPY2 trial120
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site119
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer118
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma114
Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy114
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer113
Immune phenotypic linkage between colorectal cancer and liver metastasis113
Activating a collaborative innate-adaptive immune response to control metastasis111
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer111
The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth111
Tumor organoids: Opportunities and challenges to guide precision medicine111
Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity107
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells106
Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma105
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways103
Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations102
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation101
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia101
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer100
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress100
Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription99
Artificial intelligence for multimodal data integration in oncology99
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway98
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms97
Dietary Approaches to Cancer Therapy97
The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma96
CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma95
Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer95
Pan-cancer integrative histology-genomic analysis via multimodal deep learning93
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer93
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence93
Immunogenomic Landscape of Hematological Malignancies93
The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H192
Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance90
Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies89
Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer89
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment89
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation89
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response89
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage87
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy86
Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity86
Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas86
Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma85
Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer85
Melanoma models for the next generation of therapies85
Acute Immune Signatures and Their Legacies in Severe Acute Respiratory Syndrome Coronavirus-2 Infected Cancer Patients85
Bevacizumab plus erlotinib in Chinese patients with untreated, EGFR-mutated, advanced NSCLC (ARTEMIS-CTONG1509): A multicenter phase 3 study85
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis83
Targeting pan-essential genes in cancer: Challenges and opportunities83
THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells82
Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma81
Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies81
Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies80
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity80
Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion77
Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy76
Anti-spike antibody response to SARS-CoV-2 booster vaccination in patients with B cell-derived hematologic malignancies76
MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells75
Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer75
EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition75
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia73
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression71
Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia71
PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity69
Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma69
Evaluation of cell-free DNA approaches for multi-cancer early detection67
Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer67
Activity of AZD7442 (tixagevimab-cilgavimab) against Omicron SARS-CoV-2 in patients with hematologic malignancies66
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance66
A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer66
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer66
Cell Lineage-Based Stratification for Glioblastoma64
Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance64
Cytokine Storms in Cancer and COVID-1964
The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support63
Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer63
Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation62
Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment62
Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer62
Epigenomic Reprogramming as a Driver of Malignant Glioma62
Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity62
From bench to bedside: Single-cell analysis for cancer immunotherapy62
High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer62
Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance61
Serial assessment of measurable residual disease in medulloblastoma liquid biopsies61
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor61
Metabolic programming and immune suppression in the tumor microenvironment60
Oncolytic virotherapy-mediated anti-tumor response: a single-cell perspective60
Tumor heterogeneity60
FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer59
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis59
Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis58
The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance58
Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia57
Variable cellular responses to SARS-CoV-2 in fully vaccinated patients with multiple myeloma56
A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers55
Molecular classification and diagnostics of upper urinary tract urothelial carcinoma55
Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer55
Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis54
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells54
Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance54
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity53
Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas52
Innate immune cells in the tumor microenvironment52
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates52
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model51
Cancer Care Disparities during the COVID-19 Pandemic: COVID-19 and Cancer Outcomes Study50
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma50
Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function50
Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer Patients50
COVID-19 mRNA booster vaccines elicit strong protection against SARS-CoV-2 Omicron variant in patients with cancer50
Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia49
Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells48
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia48
Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity48
Comparative Molecular Life History of Spontaneous Canine and Human Gliomas48
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