Cancer Cell

Article	Citations
Long-range cholinergic input promotes glioblastoma progression	2586
Lymphoma accelerates T cell and tissue aging	659
KIT as a therapeutic target in neuroendocrine prostate cancer	641
The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression	588
Characterization of the generic mutant p53-rescue compounds in a broad range of assays	477
Accelerated approvals: Early-phase success or premature authorization?	457
A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture	413
Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas	400
TAMing immunity through an unexpected source	400
Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton	388
Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions	371
KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition	338
Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer	324
Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations	317
Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer	311
Diet-microbiome interactions in cancer	309
Spatial profiling technologies illuminate the tumor microenvironment	293
EGFR-activated myofibroblasts promote metastasis of pancreatic cancer	290
Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling	277
Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer	271
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target	271
Dynamic circulating tumor DNA during chemoradiotherapy predicts clinical outcomes for locally advanced non-small cell lung cancer patients	271
A holistic view of cancer	268
T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation	265
A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma	265

T cell dynamism and immune-related adverse events	265
B cell heterogeneity in cancer comes of age	265
Enhanced SARS-CoV-2 breakthrough infections in patients with hematologic and solid cancers due to Omicron	264
Neutralization breadth of SARS-CoV-2 viral variants following primary series and booster SARS-CoV-2 vaccines in patients with cancer	257
Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses	257
Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity	251
Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma	248
Cancer vaccines	245
Elucidating acquired PARP inhibitor resistance in advanced prostate cancer	238
The aging lung microenvironment awakens melanoma metastases	223
Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin	221
High endothelial venules in cancer: Regulation, function, and therapeutic implication	215
Bacteria in metastatic sites: Unveiling hidden players in cancer progression	208
Challenges in neoantigen-directed therapeutics	207
Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer	202
Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors	200
Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer	199
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer	196
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments	194
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer	185
Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses	184
Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts	182
Tumor-directed dysregulation of erythroid progenitors drives immunosuppressive myeloid cells	182
Are we ready to look beyond plasma cells in assessing high-risk smoldering myeloma?	181
Gut microbes promote chemoradiotherapy resistance via metabolic cross-feeding	172
A genetic portrait of metastatic seeds in lung adenocarcinoma	167
The one-two punch: TIM-3 blockade targets immune and tumor cells to knock out pediatric brain tumors	166
Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation	166
Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients	165
Prior anti-CTLA-4 therapy impacts molecular characteristics associated with anti-PD-1 response in advanced melanoma	165
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification	165
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer	164
Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy	164
Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma	162
Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population	161
Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma	159
Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer	158
Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation	156
Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas	154
Challenges and opportunities for modeling aging and cancer	152
Immunosensitivity cuts across mismatch repair status in colorectal cancer	151
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression	151
Revisiting TNM staging for EBV-related nasopharyngeal carcinoma	151
Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics	150
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer	150
Hypoxia inducible factor-1α drives cancer resistance to cuproptosis	143
Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy	139
MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells	137
Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment	136
Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis	135

Recognition of observer effect is required for rigor and reproducibility of preclinical animal studies	132
Response-based molecular subtyping—emergence of the third generation of breast cancer subtypes	132
Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers	132
Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma	132
Midkine as a driver of age-related changes and increase in mammary tumorigenesis	131
Hepatobiliary tumor organoids for personalized medicine: a multicenter view on establishment, limitations, and future directions	130
Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells	130
Immune determinants of the pre-metastatic niche	129
Tumor-infiltrating lymphocytes: A new hope	129
Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD	129
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness	126
A path to translation: How 3D patient tumor avatars enable next generation precision oncology	125
Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1	123
Integrated proteogenomic characterization of glioblastoma evolution	122
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring	121
Precise patient stratification in esophageal cancer: Biomarkers for immunochemotherapy	121
GDF15 research from bench to bedside	120
Tumor-infiltrating bacteria disrupt cancer epithelial cell interactions and induce cell-cycle arrest	120
T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to squamous cancers	119
A circular RNA in neuroendocrine carcinomas	119
Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma	119
CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma	119
Firing up neutrophil anti-tumor immunity with cocktails	118
JUPITER-06 establishes immune checkpoint inhibitors as essential first-line drugs for the treatment of advanced esophageal squamous cell carcinoma	116
Risk factors for poor humoral response to primary and booster SARS-CoV-2 vaccination in hematologic and oncological outpatients—COVIDOUT study	115
Tumors on different wavelengths	115
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma	114
The winner takes it all: Competition drives clonal selection in gliomagenesis	113
Taxanes directly induce T cell cytotoxic extracellular vesicles to eradicate tumor cells	113
New horizons at the interface of artificial intelligence and translational cancer research	112
Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma	112
Effect of neoadjuvant chemoradiotherapy with or without PD-1 antibody sintilimab in pMMR locally advanced rectal cancer: A randomized clinical trial	112
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance	107
Proteogenomic data and resources for pan-cancer analysis	106
Distinct spatiotemporal dynamics of CD8+ T cell-derived cytokines in the tumor microenvironment	105
Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer	104
GD2-CAR T cells in patients with osteosarcoma and neuroblastoma—it’s not only the T cells that matter	102
Integrated single cell analysis reveals co-evolution of malignant B cells and tumor micro-environment in transformed follicular lymphoma	102
Enhanced but variant-dependent serological and cellular immune responses to third-dose BNT162b2 vaccination in patients with multiple myeloma	102
Cellular senescence in precancer lesions and early-stage cancers	101
Lactobacillus reuteri—an old acquaintance takes on a new task in colorectal tumor surveillance	101
Hidden spark: From cold to hot in BRAF colorectal cancer	98
An immunogenic and oncogenic feature-based classification for chemotherapy plus PD-1 blockade in advanced esophageal squamous cell carcinoma	97
Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer	96
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer	96
Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models	95
Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures	94
Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers	93
Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia	92
Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer	92
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4	92
KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer	91
Plasma cell and cancer stem cell crosstalk in glioblastoma	91
From intestinal metaplasia to gastric cancer: Witnessing the rise of evil over time and space	90
PD-1 blockade is a promising therapeutic addition to neoadjuvant chemoradiation in locally advanced rectal cancer	90
Getting a handle on KRAS inhibitor resistance with hapten-mediated anti-tumor immunity	89
Seed or soil: Tracing the immune subsets in metastatic tumors	88
Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity	86
Stromal barriers to the abscopal effect	86
Neoadjuvant treatment of IBI310 plus sintilimab in locally advanced MSI-H/dMMR colon cancer: A randomized phase 1b study	86
Engineering myeloid cells for cancer immunotherapy	85
Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow	84
Stromal lipid species dictate melanoma metastasis and tropism	84
Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy	83
Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy	82
The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells	82
Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers	80
Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance	80
High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer	79
Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis	79
Phenotypic signatures of circulating neoantigen-reactive CD8+ T cells in patients with metastatic cancers	78
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site	78
Tumor microbiome links cellular programs and immunity in pancreatic cancer	78
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice	77
Architecture sets the path: Breast cancer subtypes differently shape the early brain metastatic niche	76
Identification of specific PP2A complexes involved in human cell transformation	76
When immunotherapy meets surgery in non-small cell lung cancer	75
Vascular characterization reveals immunomodulatory targets for brain metastases	75
Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity	75
Comprehensive tumor-immune profiling reveals mediators of paradoxical immune sensitivity in sarcomatoid renal cell carcinoma	74

Increased antibody titers and reduced seronegativity following fourth mRNA COVID-19 vaccination in patients with cancer	74
Spatial patterns of glioblastoma	73
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma	73
Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition	73
TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak	72
A first-in-class EGFR-directed KRAS G12V selective inhibitor	72
Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors	71
Nivolumab combined with induction chemotherapy and radiotherapy in nasopharyngeal carcinoma: A multicenter phase 2 PLATINUM trial	71
Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding	71
Subclonal immune evasion in non-small cell lung cancer	71
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer	71
Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer	70
Genomic mapping of metastatic organotropism in lung adenocarcinoma	69
The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative	69
When essential metal elements become culprits—Cuproptosis in focus	68
A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression	68
Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression	68
Immune memory shapes ovarian cancer recurrence	68
Combining personalized neoantigen vaccination with chemotherapy and anti-PD-1 to treat NSCLC	68
The coming era of nudge drugs for cancer	67
Engineered natural killer cells for cancer therapy	67
Bridging the gap: The future of cancer research and clinical oncology in Cancer Cell	66
The liver as a cytokine factory working on mRNA blueprints for cancer immunotherapy	65
Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer	64
Neutrophil-activating therapy for the treatment of cancer	64
A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma	63
Sex and cancer immunotherapy: Current understanding and challenges	61
Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread	60
Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma	60
Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance	60
Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade	60
Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice	60
IL-6 blockade in cancer patients treated with immune checkpoint blockade: A win-win strategy	59
Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment	59
Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition	59
Immune phenotypic linkage between colorectal cancer and liver metastasis	59
TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors	58
Metabolic regulation of Cathepsin B in tumor macrophages drives their pro-metastatic function	58
Remodeling of T and endothelial cells during total neoadjuvant therapy in rectal cancer	57
A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis	57
Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis	57
Rethinking relief: Targeting sensory neurons to combat cancer and pain	57
IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment	56
Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors	56
Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma	55
Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer	54
TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory	54
Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts	54
A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers	54
The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells	54
Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity	54