Cancer Cell

(The TQCC of Cancer Cell is 47. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
Oxidative Stress in Cancer1199
A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications582
Conserved pan-cancer microenvironment subtypes predict response to immunotherapy503
The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker482
Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance476
Acquired Resistance to Immune Checkpoint Inhibitors431
Overcoming Endocrine Resistance in Breast Cancer411
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities408
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion377
Engineering CAR-T Cells for Next-Generation Cancer Therapy338
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth323
Proteogenomic and metabolomic characterization of human glioblastoma319
The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes297
Clinical Challenges of Immune Checkpoint Inhibitors277
Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer270
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments267
Seroconversion rates following COVID-19 vaccination among patients with cancer267
Challenges and Opportunities for Pancreatic Cancer Immunotherapy267
Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer266
Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma264
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4257
Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade256
MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate255
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation250
Targeting the MAPK Pathway in KRAS-Driven Tumors249
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma246
Response and Resistance to BCR-ABL1-Targeted Therapies244
Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas239
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma228
Liquid Biopsy-Based Biomarkers of Treatment Response and Resistance215
Antibody response to SARS-CoV-2 vaccines in patients with hematologic malignancies214
Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells213
Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial213
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution206
Targeting cell-cycle machinery in cancer202
Microbiome and cancer201
Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition195
YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis193
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma187
Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors187
COVID-19 and Cancer: Current Challenges and Perspectives186
Immunogenicity of SARS-CoV-2 messenger RNA vaccines in patients with cancer186
SARS-CoV-2 Viral Load Predicts Mortality in Patients with and without Cancer Who Are Hospitalized with COVID-19184
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma183
Advancing Cancer Research and Medicine with Single-Cell Genomics179
Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer177
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy176
Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial176
Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver174
Immunometabolic Interplay in the Tumor Microenvironment173
Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple myeloma168
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma167
Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states160
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade159
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer158
Biomolecular Condensates and Cancer155
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity155
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer153
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification153
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer152
Mutant p53 suppresses innate immune signaling to promote tumorigenesis151
Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL151
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations149
Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer148
DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity148
The Glioma Stem Cell Model in the Era of Single-Cell Genomics147
Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer147
Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer142
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma140
IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis140
Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma138
An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence138
Artificial intelligence for clinical oncology136
KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer134
Integrated Omics of Metastatic Colorectal Cancer133
Immunomodulation by targeted anticancer agents132
Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells132
Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II/III breast cancer: Results from the adaptively randomized I-SPY2 trial129
Immune phenotypic linkage between colorectal cancer and liver metastasis129
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site128
Antibody and T cell immune responses following mRNA COVID-19 vaccination in patients with cancer126
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer126
Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy124
Tumor organoids: Opportunities and challenges to guide precision medicine124
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer120
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma120
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer120
Artificial intelligence for multimodal data integration in oncology120
Activating a collaborative innate-adaptive immune response to control metastasis119
The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth119
Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma115
Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer114
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer114
Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity114
Pan-cancer integrative histology-genomic analysis via multimodal deep learning113
Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription111
Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations111
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways107
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress106
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms106
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway105
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia105
Dietary Approaches to Cancer Therapy105
The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma104
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation104
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence103
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment101
Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance99
The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H198
Immunogenomic Landscape of Hematological Malignancies97
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy97
Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer97
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer96
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage94
Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies94
Melanoma models for the next generation of therapies93
Bevacizumab plus erlotinib in Chinese patients with untreated, EGFR-mutated, advanced NSCLC (ARTEMIS-CTONG1509): A multicenter phase 3 study92
Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity92
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation91
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response91
Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies90
Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer90
Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma89
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis89
Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion88
Targeting pan-essential genes in cancer: Challenges and opportunities88
Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas87
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity86
Acute Immune Signatures and Their Legacies in Severe Acute Respiratory Syndrome Coronavirus-2 Infected Cancer Patients86
Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies85
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia84
High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer84
Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma82
MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells81
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance79
Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer78
Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer78
Anti-spike antibody response to SARS-CoV-2 booster vaccination in patients with B cell-derived hematologic malignancies77
Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy77
Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia76
Evaluation of cell-free DNA approaches for multi-cancer early detection75
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression74
Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma74
Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance74
Metabolic programming and immune suppression in the tumor microenvironment73
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor73
PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity73
The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support70
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy70
Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity69
Activity of AZD7442 (tixagevimab-cilgavimab) against Omicron SARS-CoV-2 in patients with hematologic malignancies69
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer69
A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer69
From bench to bedside: Single-cell analysis for cancer immunotherapy67
Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer66
Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation66
Cytokine Storms in Cancer and COVID-1966
Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance65
Cell Lineage-Based Stratification for Glioblastoma65
Tumor heterogeneity65
Epigenomic Reprogramming as a Driver of Malignant Glioma65
Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance65
FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer64
A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers64
Serial assessment of measurable residual disease in medulloblastoma liquid biopsies63
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis62
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia62
Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment62
Oncolytic virotherapy-mediated anti-tumor response: a single-cell perspective61
Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function59
The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance59
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity58
Molecular classification and diagnostics of upper urinary tract urothelial carcinoma58
Variable cellular responses to SARS-CoV-2 in fully vaccinated patients with multiple myeloma58
Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia57
Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity56
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells56
Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis56
Innate immune cells in the tumor microenvironment56
Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells55
Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin55
Pan-cancer proteomic map of 949 human cell lines55
IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer54
Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia54
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model54
Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer Patients52
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma52
COVID-19 mRNA booster vaccines elicit strong protection against SARS-CoV-2 Omicron variant in patients with cancer51
Cancer Care Disparities during the COVID-19 Pandemic: COVID-19 and Cancer Outcomes Study50
Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes49
B cells and cancer48
Tumor microbiome links cellular programs and immunity in pancreatic cancer48
Interleukin-1 in tumor progression, therapy, and prevention48
Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers48
TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma48
The therapeutic window of antibody drug conjugates: A dogma in need of revision47
Personalized neoantigen vaccine NEO-PV-01 with chemotherapy and anti-PD-1 as first-line treatment for non-squamous non-small cell lung cancer47
STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma47
SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy47
STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma47