Cancer Cell

Papers
(The H4-Index of Cancer Cell is 100. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth788
Conserved pan-cancer microenvironment subtypes predict response to immunotherapy622
The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker611
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities503
Proteogenomic and metabolomic characterization of human glioblastoma369
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments363
The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes359
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4358
Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer358
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation331
Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer327
Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma324
Challenges and Opportunities for Pancreatic Cancer Immunotherapy321
Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade311
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma302
Seroconversion rates following COVID-19 vaccination among patients with cancer280
Microbiome and cancer276
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma267
Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells262
Targeting cell-cycle machinery in cancer261
Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver231
YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis230
Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial229
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma227
Antibody response to SARS-CoV-2 vaccines in patients with hematologic malignancies223
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy221
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer219
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma213
Immunometabolic Interplay in the Tumor Microenvironment208
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer207
Artificial intelligence for multimodal data integration in oncology205
Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer199
COVID-19 and Cancer: Current Challenges and Perspectives199
Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states196
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade194
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity192
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification192
SARS-CoV-2 Viral Load Predicts Mortality in Patients with and without Cancer Who Are Hospitalized with COVID-19191
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer189
Mutant p53 suppresses innate immune signaling to promote tumorigenesis189
Immunogenicity of SARS-CoV-2 messenger RNA vaccines in patients with cancer189
Biomolecular Condensates and Cancer183
Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL182
Immune phenotypic linkage between colorectal cancer and liver metastasis182
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations180
Pan-cancer integrative histology-genomic analysis via multimodal deep learning178
Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple myeloma175
DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity173
Artificial intelligence for clinical oncology170
Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma165
An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence163
Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II/III breast cancer: Results from the adaptively randomized I-SPY2 trial162
Integrated Omics of Metastatic Colorectal Cancer161
Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer161
Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma157
Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity155
Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer155
Tumor organoids: Opportunities and challenges to guide precision medicine155
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer154
Immunomodulation by targeted anticancer agents153
The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth151
Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy150
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer149
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site147
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence145
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma144
Activating a collaborative innate-adaptive immune response to control metastasis143
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer143
Metabolic programming and immune suppression in the tumor microenvironment143
High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer139
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms138
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia137
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation135
Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription134
The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma134
Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations134
Antibody and T cell immune responses following mRNA COVID-19 vaccination in patients with cancer133
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy133
Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance132
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway129
Evaluation of cell-free DNA approaches for multi-cancer early detection128
Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies127
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment127
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy125
The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1124
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress123
Melanoma models for the next generation of therapies122
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance120
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage119
Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer119
Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance115
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia113
Targeting pan-essential genes in cancer: Challenges and opportunities113
Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion112
Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer112
Bevacizumab plus erlotinib in Chinese patients with untreated, EGFR-mutated, advanced NSCLC (ARTEMIS-CTONG1509): A multicenter phase 3 study110
Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity107
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis106
MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells106
Spatial profiling technologies illuminate the tumor microenvironment101
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