Experimental Biology and Medicine

Article	Citations
The β-catenin/CBP signaling axis participates in sepsis-induced inflammatory lung injury	102
Mutant U2AF1-induced differential alternative splicing causes an oxidative stress in bone marrow stromal cells	67
Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma	55
Identification of key genes involved in calcific aortic valve disease based on integrated bioinformatics analysis	50
Stattic alleviates pulmonary fibrosis in a mouse model of rheumatoid arthritis–relevant interstitial lung disease	44
Penicillin-binding protein (PBP) inhibitor development: A 10-year chemical perspective	40
Safety and feasibility of the gene transfer of hemopexin for conditions with increased free heme	39
Assessment of the influence on left ventricle by potassium oxonate and hypoxanthine–induced chronic hyperuricemia	36
Dual detection of COVID-19 antigens and antibodies using nanoscale fluorescent plasmonic substrates	34
Bioinformatics analysis of the genes associated with co-occurrence of heart failure and lung cancer	33
TFPI and FXIII negatively and S100A8/A9 and Cystatin C positively correlate with D-dimer in COVID-19	32
Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats	29
Pyrotinib combining with radiotherapy on breast cancer with brain metastasis	29
Protective effects of molecular hydrogen on lung injury from lung transplantation	26
Circulating exosomal microRNA-4497 as a potential biomarker for metastasis and prognosis in non-small-cell lung cancer	26
Effects of autoimmune abnormalities on skeletal muscle regeneration after needle puncture in mice	25
The role of calcium-sensing receptor signaling in regulating transepithelial calcium transport	25
Osteopontin as a biomarker for COVID-19 severity and multisystem inflammatory syndrome in children: A pilot study	24
Is COVID-19-associated cytokine storm distinct from non-COVID-19 secondary hemophagocytic lymphohistiocytosis?	22
Green synthesized silver nanoparticles for the treatment of diabetes and the related complications of hyperlipidemia and oxidative stress in diabetic rats	22
E2F3 drives the epithelial-to-mesenchymal transition, cell invasion, and metastasis in breast cancer	22
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer	21
Structural analysis of SARS-Cov-2 nonstructural protein 1 polymorphisms found in the Brazilian Amazon	21
Mechanisms of cell injury induced by inhaled molybdenum trioxide nanoparticles in Golden Syrian Hamsters	20
What do over-trained athletes and patients with neurodegenerative diseases have in common? Mitochondrial dysfunction	20

Identification of key biomarkers for thyroid cancer by integrative gene expression profiles	19
Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China	19
Influence of polymorphic variations of IFNL, HLA, and IL-6 genes in severe cases of COVID-19	19
Research of restricted migration evaluation of MDA-MB-231 cells in 2D and 3D co-culture models	19
A quantum-based oversampling method for classification of highly imbalanced and overlapped data	18
Impacts of microgravity on amino acid metabolism during spaceflight	18
Therapeutic strategies to improve liver regeneration after hepatectomy	18
Changes in gene expression and neuroinflammation in the hippocampus of rats with poststroke cognitive impairment	18
Identifying a cervical cancer survival signature based on mRNA expression and genome-wide copy number variations	18
Matrix metalloproteinases are key targets of acupuncture in the treatment of ulcerative colitis	18
Endogenous drivers of altered immune cell metabolism	18
Mouse embryonic stem cells require multiple amino acids	18
A review on photo-mediated ultrasound therapy	17
Rett and Rett-related disorders: Common mechanisms for shared symptoms?	17
Quantitative multiplexed strategies for human Lyme disease serological testing	17
Bioelectric, tissue, and molecular characteristics of the gastric mucosa at different times of ischemia	16
Protective effect of aldehyde dehydrogenase 2 against rat corneal dysfunction caused by streptozotocin-induced type I diabetes	16
Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes	16
Development of a novel purification protocol to isolate and identify brain microglia	16
Risk factors for neonatal VAP: A retrospective cohort study	15
Strategies for intra-amniotic administration of fetal therapy in a rabbit model of intrauterine growth restriction	15
In vivo visualization and analysis of ciliary motion in allergic rhinitis models induced by ovalbumin	15
Roles of IL-33 in the Pathogenesis of Cardiac Disorders	15
Introduction to the Regenerative Medicine Thematic Issue	15
Circulating H-FABP as a biomarker of frailty in patients with chronic heart failure	15
Particulate matter exposure predicts residence in high-risk areas for community acquired pneumonia among hospitalized children	15
Calcitriol ameliorates damage in high-salt diet-induced hypertension: Evidence of communication with the gut–kidney axis	15
Revisiting the role of lysophosphatidic acid in stem cell biology	14
Store-operated Ca2+ channel signaling: Novel mechanism for podocyte injury in kidney disease	14
Transcriptomic profiling of cerebrospinal fluid identifies ALS pathway enrichment and RNA biomarkers in MND individuals	14
GPER1 contributes to T3-induced osteogenesis by mediating glycolysis in osteoblast precursors	14
Three-dimensional segmentation and depth-encoded visualization of choroidal vasculature using swept-source optical coherence tomography	14
In vitro contractile studies within isolated tissue baths: Translational research from Visible Heart® Laboratories	14
The role of mediator complex subunit 19 in human diseases	14
Proteomics analysis of carotid body tumor revealed potential mechanisms and molecular differences among Shamblin classifications	14
The third dimension of tumor microenvironment—The importance of tumor stroma in 3D cancer models	14
Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus	14
Effects of moderate-continuous and high-intensity interval aerobic training on cardiac function of spontaneously hypertensive rats	14
Participation of ASK-1 in the cardiomyocyte-protective role of mechanical ventilation in a rat model of myocardial infarction	14
Engineering microenvironments for manufacturing therapeutic cells	14
Enriched environment as a nonpharmacological neuroprotective strategy	13
SARS-CoV-2 variants: A double-edged sword?	13
Apelin-13 prevents the effects of oxygen–glucose deprivation/reperfusion on bEnd.3 cells by inhibiting AKT–mTOR signaling	13
Comprehensive analysis of INHBA: A biomarker for anti-TGFβ treatment in head and neck cancer	13
Paraoxonase 1 rs662 polymorphism, its related variables, and COVID-19 intensity: Considering gender and post-COVID complications	13
Normative intercapillary distance and vessel density data in the temporal retina assessed by wide-field spectral-domain optical coherence tomography angiography	13
Therapeutic potentials of stem cell–derived exosomes in cardiovascular diseases	13
Identification in synovial fluid of a new potential pathogenic player in arthropathies	13
Identification of SARS-CoV-2 on the ocular surface in a cohort of COVID-19 patients from Brazil	13
Single-cell RNA sequencing reveals differential expression of EGFL7 and VEGF in giant-cell tumor of bone and osteosarcoma	12

Qualification of translational safety biomarkers	12
MiR-296-5p ameliorates deep venous thrombosis by inactivating S100A4	12
Apigeninidin-enriched Sorghum bicolor (L. Moench) extracts alleviate Aflatoxin B1-induced dysregulation of male rat hypothalamic-reproductive axis	12
Heterogeneity of humoral response patterns in mildly symptomatic, non-hospitalized COVID-19 patients: A one-year longitudinal study	12
The intestinal microbiota as mediators between dietary contaminants and host health	11
CD9, a tetraspanin target for cancer therapy?	11
Regenerative and stem cell-based techniques for facial rejuvenation	11
Deep learning prediction of attention-deficit hyperactivity disorder in African Americans by copy number variation	11
Regulation of Th1/Th2 and Th17/Treg by pDC/mDC imbalance in primary immune thrombocytopenia	11
Metformin and retinal diseases in preclinical and clinical studies: Insights and review of literature	11
Therapeutically leveraging GABAA receptors in cancer	11
Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes	11
Machine learning and deep learning for brain tumor MRI image segmentation	11
Cell cycle disturbances in mucopolysaccharidoses: Transcriptomic and experimental studies on cellular models	11
Decision rules for personalized statin treatment prescriptions over multi-objectives	11
Identifying immune subtypes of uterine corpus endometrial carcinoma and a four-paired-lncRNA signature with immune-related lncRNAs	11
Going with the grain: Fiber, cognition, and the microbiota-gut-brain-axis	11
Combining contrast-enhanced ultrasound and blood cell analysis to improve diagnostic accuracy of plasma cell mastitis	11
Niacin promotes the efflux of lysosomal cholesterol from macrophages via the CD38/NAADP signaling pathway	10
Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats	10
Clinical and genetic investigations in Chinese families with retinitis pigmentosa	10
Hyperinflammation, apoptosis, and organ damage	10
WISP1 aggravates cell metastatic potential by abrogating TGF-β-Smad2/3-dependent epithelial-to-mesenchymal transition in laryngeal squamous cell carcinoma	10
Evolving techniques for reducing phantom limb pain	10
Preclinical and clinical studies of bintrafusp alfa, a novel bifunctional anti-PD-L1/TGFβRII agent: Current status	10
Contusion concomitant with ischemia injury aggravates skeletal muscle necrosis and hinders muscle functional recovery	10
Diagnostic and prognostic nomograms for newly diagnosed intrahepatic cholangiocarcinoma with brain metastasis: A population-based analysis	10
Corrigendum	9
Creative and generative artificial intelligence for personalized medicine and healthcare: Hype, reality, or hyperreality?	9
EXPRESSION OF CONCERN: Diabetic human adipose tissue-derived mesenchymal stem cells fail to differentiate in functional adipocytes	9
Abdominal paracentesis drainage attenuates intestinal mucosal barrier damage through macrophage polarization in severe acute pancreatitis	9
Identification of molecular subtyping system and four-gene prognostic signature with immune-related genes for uveal melanoma	9
Wogonin, as a potent anticancer compound: From chemistry to cellular interactions	9
Corrigendum	9
ONECUT2 which is targeted by hsa-miR-15a-5p enhances stemness maintenance of gastric cancer stem cells	9
Gentiopicroside alleviates acute myocardial infarction injury in rats by disrupting Nrf2/NLRP3 signaling	9
Fetuin-A exerts a protective effect against experimentally induced intestinal ischemia/reperfusion by suppressing autophagic cell death	9
EXPRESSION OF CONCERN: Chondroitin-4-Sulphate Reduced Oxidative Injury in Caerulein-Induced Pancreatitis in Mice: The Involvement of NF-κB Translocation and Apoptosis Activation	9
Melatonin pretreatment modulates anti-inflammatory, antioxidant, YKL-40, and matrix metalloproteinases in endotoxemic rat lung tissue	9
S-allylmercapto-N-acetylcysteine protects bone cells from oxidation and improves femur microarchitecture in healthy and diabetic mice	9
Nucleated red blood cells participate in myocardial regeneration in the toad Bufo Gargarizan Gargarizan	8
The continuing evolution of barcode applications: Functional toxicology to cell lineage	8
Mesenchymal stem cells with p38 mitogen-activated protein kinase interference ameliorate mouse ischemic stroke	8
TGFβ1 induces CXCL1 to promote stemness features in lung cancer	8
Association between serum placental growth factor and vascular endothelial function in hyprtensive disorders complicating pregnancy	8
New and effective method to develop primary hepatocytes from liver cancer patients	8
Toll-like receptor 3 signaling induces interferon-induced transmembrane protein 1 in BEAS-2B cells	8
The infrapatellar fat pad contributes to spontaneous healing after complete anterior cruciate ligament injury	8
Image reconstruction for endoscopic photoacoustic tomography including effects of detector responses	8
Serum homocysteine is a valuable marker for predicting aggravation of infection in intestinal obstruction patients	8
Combining tissue clearing and Fluoro-Jade C labeling for neurotoxicity assessments	8
Autotaxin–lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling	8
Association of genetic variants rs641153 (CFB), rs2230199 (C3), and rs1410996 (CFH) with age-related macular degeneration in a Brazilian population	7
High-quality RNA improves sensitivity of SARS-CoV-2 detection by colorimetric RT-LAMP	7
Ginkgolide B promotes oligodendrocyte precursor cell differentiation and survival via Akt/CREB/bcl-2 signaling pathway after white matter lesion	7
The influence of multidisciplinary team clinic on the prognosis of patients with chronic kidney disease	7
HnRNP K regulates inflammatory gene expression by mediating splicing pattern of transcriptional factors	7
miR-31 promotes neural stem cell proliferation and restores motor function after spinal cord injury	7
Neonatal coagulopathies: A review of established and emerging treatments	7
Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging	7
Vagal milieu or electrophysiologic substrate? The link between atrial fibrillation and obstructive sleep apnea	7
Stopping the COVID-19 pandemic in dental offices: A review of SARS-CoV-2 transmission and cross-infection prevention	7
Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography	7
Circulating LIPCAR is a potential biomarker of heart failure in patients post-acute myocardial infarction	7
Engineered collagen-binding bone morphogenetic protein-2 incorporated with platelet-rich plasma accelerates lumbar fusion in aged rats with osteopenia	7
Antibiotic impregnation and nanocoating of external ventricular drainage catheters for antibacterial applications: Evaluation of in vitro studies and molecular docking	7
Oral microbiota in human health and disease: A perspective	7
Systematic analysis of molecular characterization and clinical relevance of m6A regulators in digestive system pan-cancers	7
N-acetylcysteine improves autism-like behavior by recovering autophagic deficiency and decreasing Notch-1/Hes-1 pathway activity	7
Dietary supplementation with L-leucine reduces nitric oxide synthesis by endothelial cells of rats	7
Cassava microfiber–reinforced gelatin scaffold holds promise for tissue engineering by exhibiting cytocompatibility with HEK 293 cells	7
Role of long interspersed nuclear element-1 in the regulation of chromatin landscapes and genome dynamics	7
The expression and function of growth hormone secretagogue receptor in immune cells: A current perspective	7
Molecular and environmental contributors to neurological complications in sickle cell disease	7
Identification of a circRNA-mediated comprehensive ceRNA network in spinal cord injury pathogenesis	7
Data science in drug discovery safety: Challenges and opportunities	7
Focused ultrasound stimulation on meibomian glands for the treatment of evaporative dry eye	7
Differential expression profile of plasma exosomal microRNAs in chronic rhinosinusitis with nasal polyps	7
Neutrophil extracellular traps contributing to atherosclerosis: From pathophysiology to clinical implications	7
Manipulation of genes could inhibit SARS-CoV-2 infection that causes COVID-19 pandemics	7

Sex differences in muscle SIRT1 and SIRT3 and exercise + weight loss effects on muscle sirtuins	7
Arbutin ameliorates glucocorticoid-induced osteoporosis through activating autophagy in osteoblasts	6
URNet: System for recommending referrals for community screening of diabetic retinopathy based on deep learning	6
CCK2-receptor deficiency impairs immune balance by influencing CD4+ T cells development by inhibiting cortical-thymic-epithelial-cells	6
Comprehensive analysis of dysregulated genes associated with atherosclerotic plaque destabilization	6
Synthesis of glycine from 4-hydroxyproline in tissues of neonatal pigs with intrauterine growth restriction	6
Cellular senescence and the blood–brain barrier: Implications for aging and age-related diseases	6
Indoxyl sulfate impairs in vitro erythropoiesis by triggering apoptosis and senescence	6
Phenethyl isothiocyanate protects against cyclophosphamide-induced nephrotoxicity via nuclear factor E2–related factor 2 pathway in rats	6
Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells	6
c-Src inhibitor PP2 inhibits head and neck cancer progression through regulation of the epithelial–mesenchymal transition	6
PGM3 regulates beta-catenin activity to promote colorectal cancer cell progression	6
Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy	6
Cancer and stem cells	6
Enhancing the sensitivity of ovarian cancer cells to olaparib via microRNA-20b-mediated cyclin D1 targeting	6
Mild hypobaric hypoxia influences splenic proliferation during the later phase of stress erythropoiesis	6
Classification of salivary bacteriome in asymptomatic COVID-19 cases based on long-read nanopore sequencing	6
In vitro comparative evaluation of Tamarix gallica extracts for antioxidant and antidiabetic activity	6
TRIM28 suppresses cancer stem-like characteristics in gastric cancer cells through Wnt/β-catenin signaling pathways	6
Aldh1a1andScl25a30in diaphragmatic dysfunction	6
Formyl peptide receptor 1 promotes podocyte injury through regulation of mitogen-activated protein kinase pathways	6
The “ideal protein” concept is not ideal in animal nutrition	6
Regulation of lymphangiogenesis by extracellular vesicles in cancer metastasis	6
Improved protocol for Bst polymerase and reverse transcriptase production and application to a point-of-care diagnostics system	6
Epigallocatechin-3-gallate ameliorates renal endoplasmic reticulum stress-mediated inflammation in type 2 diabetic rats	6
BPA interferes with granulosa cell development and oocyte meiosis in mouse preantral follicles	6
MicroRNA 205-5p and COVID-19 adverse outcomes: Potential molecular biomarker and regulator of the immune response	6
A primordial target: Mitochondria mediate both primary and collateral anesthetic effects of volatile anesthetics	6
Implications of fibrotic extracellular matrix in diabetic retinopathy	6
Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion	6
High ROBO3 expression predicts poor survival in non-M3 acute myeloid leukemia	6
Effect of vitamin D3 supplementation on hepatic lipid dysregulation associated with autophagy regulatory AMPK/Akt-mTOR signaling in type 2 diabetic mice	6
Challenges of applying circulating biomarkers for abdominal aortic aneurysm progression	6
Shear type and magnitude affect aortic valve endothelial cell morphology, orientation, and differentiation	6
Physical activity and exercise as an essential medical strategy for the COVID-19 pandemic and beyond	6
Transcriptomic profile of the mechanosensitive ion channelome in human cardiac fibroblasts	6
Olaparib attenuates sepsis-induced acute multiple organ injury via ERK-mediated CD14 expression	6
Corrigendum	6
Increasing adverse drug events extraction robustness on social media: Case study on negation and speculation	6
A new insight of immunosuppressive microenvironment in osteosarcoma lung metastasis	6
Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing	5
Effects of a high-salt diet on MAP and expression levels of renal ENaCs and aquaporins in SHR	5
Surface fibrils on the particles of nucleocytoviruses: A review	5
Recombinant antigen delivery to dendritic cells as a way to improve vaccine design	5
Dysregulation of brain dopamine systems in major depressive disorder	5
Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism	5
Role of sex hormones in lung cancer	5
Sex differences in prenatal programming of hypertension by dexamethasone	5
2-Bromopalmitate inhibits malignant behaviors of HPSCC cells by hindering the membrane location of Ras protein	5
CX3CR1 deficiency exacerbates immune-mediated hepatitis by increasing NF-κB-mediated cytokine production in macrophage and T cell	5
Relationship between hyperglycemia, waist circumference, and the course of COVID-19: Mortality risk assessment	5
Role of follistatin-like protein 1 in liver diseases	5
Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis	5
Recent advances in nanotechnology-enabled biosensors for detection of exosomes as new cancer liquid biopsy	5
Comparison of circulating bacterial profiles between mild and severe COVID-19 patients	5
Assessments of tumor mutational burden estimation by targeted panel sequencing: A comprehensive simulation analysis	5
Longitudinal dysregulation of long non-coding RNAs in Parkinson’s disease	5
D4F alleviates the C/EBP homologous protein-mediated apoptosis in glycated high-density lipoprotein-treated macrophages by facilitating autophagy	5
RBM25 induces trophoblast epithelial-mesenchymal transition and preeclampsia disorder by enhancing the positive feedback loop between Grhl2 and RBM25	5
Identification and validation of hub genes in CD5-positive diffuse large B-cell lymphoma	5
Pancreatic acinar cells utilize tyrosine to synthesize L-dihydroxyphenylalanine	5
Role of macrophages in the onset, maintenance, or control of arthritis caused by alphaviruses	5
Expressing MLH1 in HCT116 cells increases cellular resistance to radiation by activating the PRKAC	5
Evaluation of the mechanisms of heme-induced tissue factor activation: Contribution of innate immune pathways	5
Zebrafish patient-derived xenografts accurately and quickly reproduce treatment outcomes in non–small cell lung cancer patients	5
Recent insights into atherosclerotic plaque cell autophagy	5
Thermo- and pH-sensitive nanoparticles of poly (N-isopropylacrylamide-decenoic acid-1-vinylimidazole) for ultrasound switchable fluorescence imaging	5
Association of heme-oxygenase 1, hemopexin, and heme levels with markers of disease severity in COVID-19	5
Progress in the contrary effects of glucagon-like peptide-1 and chemerin on obesity development	5
Metabolomic profiling of anaerobic and aerobic energy metabolic pathways in chronic obstructive pulmonary disease	5
A comprehensive overview of PPM1A: From structure to disease	5
Environmentally persistent free radicals enhance SARS-CoV-2 replication in respiratory epithelium	5
Developing a SARS-CoV-2 main protease binding prediction random forest model for drug repurposing for COVID-19 treatment	5
Interleukin-10 regulates starvation-induced autophagy through the STAT3-mTOR-p70s6k axis in hepatic stellate cells	5
LncRNA XLOC_015548 affects the proliferation and differentiation of myoblasts via the MAPK signaling pathway	5
The alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents	5
Tripartite motif-containing 25 facilitates immunosuppression and inhibits apoptosis of glioma via activating NF-κB	5
Cell death signaling in Anopheles gambiae initiated by Bacillus thuringiensis Cry4B toxin involves Na+/K+ ATPase	5
The value of serum TRAP1 in diagnosing small cell lung cancer and tumor immunity	5
Fluoride induces osteoblast autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway in vivo and in vitro	5
Innovative approaches for treatment of osteosarcoma	4
Zoledronic acid modulates osteoclast apoptosis through activation of the NF-κB signaling pathway in ovariectomized rats	4
CRISPR/SaCas9-based gene editing rescues photoreceptor degeneration throughout a rhodopsin-associated autosomal dominant retinitis pigmentosa mouse model	4
Silicon: A neglected micronutrient essential for bone health	4
In-ovo imaging using ostrich eggs: Biomagnetism for detection of cardiac signals and embryonal motion	4
Bioengineering approaches to mature induced pluripotent stem cell-derived atrial cardiomyocytes to model atrial fibrillation	4
Thioredoxin-mediated alteration of protein content and cytotoxicity of Acinetobacter baumannii outer membrane vesicles	4
Delayed tezampanel and caramiphen treatment but not midazolam protects against long-term neuropathology after soman exposure	4
Phenotyping in clinical text with unsupervised numerical reasoning for patient stratification	4
Extracellular matrix metalloproteinases inducer gene polymorphism and reduced serum matrix metalloprotease-2 activity in preeclampsia patients	4
The role of IL-33/ST2 signaling in the tumor microenvironment and Treg immunotherapy	4
The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets	4
Correlation between TGF-β2/3 promoter DNA methylation and Smad signaling during palatal fusion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin	4
Selenoproteins and the senescence-associated epitranscriptome	4
Antiviral activity of medicinal plant-derived products against SARS-CoV-2	4