Developmental Cell

Article	Citations
Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract	314
Thriving under Stress: How Plants Balance Growth and the Stress Response	285
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation	244
Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force	238
Lipid metabolism in cancer: New perspectives and emerging mechanisms	209
Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates	176
Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development	166
Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn’s Disease	166
The Tubulin Code in Microtubule Dynamics and Information Encoding	161
Distinct contributions of partial and full EMT to breast cancer malignancy	161
Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis	152
ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization	151
Quality control of the mitochondrion	146
A single-cell analysis of the Arabidopsis vegetative shoot apex	144
A Single-Cell Transcriptomic Atlas of Human Skin Aging	142
Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells	138
CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos	127
Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex	125
Single-cell RNA sequencing of developing maize ears facilitates functional analysis and trait candidate gene discovery	125
Hematopoietic Stem Cell Metabolism during Development and Aging	124
Single-cell resolution of lineage trajectories in the Arabidopsis stomatal lineage and developing leaf	123
Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function	118
Niches that regulate stem cells and hematopoiesis in adult bone marrow	116
Cancer Cells Don’t Live Alone: Metabolic Communication within Tumor Microenvironments	114
Cellular Mechanisms and Regulation of Quiescence	113

Surviving and thriving: How plants perceive and respond to temperature stress	108
A Combinatorial MAP Code Dictates Polarized Microtubule Transport	107
ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress	106
In Vitro and In Vivo Development of the Human Airway at Single-Cell Resolution	104
A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants	103
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C	101
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies	100
Lipid metabolism and lipid signals in aging and longevity	97
Microtubule Nucleation Properties of Single Human γTuRCs Explained by Their Cryo-EM Structure	96
Metabolic Reprogramming Promotes Neural Crest Migration via Yap/Tead Signaling	95
Mechanical Adaptability of Tumor Cells in Metastasis	94
Intestinal Regeneration: Regulation by the Microenvironment	92
Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis	92
Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains	92
Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding	92
The single-cell stereo-seq reveals region-specific cell subtypes and transcriptome profiling in Arabidopsis leaves	90
Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival	87
The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana	87
A Dual Protein-mRNA Localization Screen Reveals Compartmentalized Translation and Widespread Co-translational RNA Targeting	87
Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy	85
Emerging Roles for Phase Separation in Plants	85
Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing	84
Gli1+ Periodontium Stem Cells Are Regulated by Osteocytes and Occlusal Force	82
Chromatin Accessibility Dynamics and a Hierarchical Transcriptional Regulatory Network Structure for Plant Somatic Embryogenesis	82
S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity	81
Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells	81
Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family	81
Enhancer grammar in development, evolution, and disease: dependencies and interplay	81
OsNSUN2-Mediated 5-Methylcytosine mRNA Modification Enhances Rice Adaptation to High Temperature	80
Integration of Hippo-YAP Signaling with Metabolism	80
Liquid-Liquid Phase Separation in Neuronal Development and Synaptic Signaling	78
Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells	78
Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins	77
Diverse nitrogen signals activate convergent ROP2-TOR signaling in Arabidopsis	76
The Lysosome at the Intersection of Cellular Growth and Destruction	76
Buckling of an Epithelium Growing under Spherical Confinement	75
Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro	74
ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD	72
Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy	72
Tissue mechanics in stem cell fate, development, and cancer	72
Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit	71
N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles	71
Illuminating NAD+ Metabolism in Live Cells and In Vivo Using a Genetically Encoded Fluorescent Sensor	70
Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring	69
Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics	68
Autophagy and organelle homeostasis in cancer	68
Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy	68
Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis	68
A census of the lung: CellCards from LungMAP	67
Fibroblast dedifferentiation as a determinant of successful regeneration	66

Next-Generation Lineage Tracing and Fate Mapping to Interrogate Development	66
Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo	66
The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells	64
Durotaxis: The Hard Path from In Vitro to In Vivo	64
Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination	64
Early human embryonic development: Blastocyst formation to gastrulation	63
Single-Cell RNA Sequencing of the Cynomolgus Macaque Testis Reveals Conserved Transcriptional Profiles during Mammalian Spermatogenesis	63
Extracellular vesicles: Critical players during cell migration	63
Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos	62
Mechanics of Development	61
Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease	61
An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells	61
Actin-Membrane Release Initiates Cell Protrusions	60
A BIN2-GLK1 Signaling Module Integrates Brassinosteroid and Light Signaling to Repress Chloroplast Development in the Dark	60
A Self-Organized PLT/Auxin/ARR-B Network Controls the Dynamics of Root Zonation Development in Arabidopsis thaliana	59
3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain	59
Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation	58
Global and Site-Specific Effect of Phosphorylation on Protein Turnover	58
Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes	58
A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver	57
Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications	57
Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production	57
Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss	57
Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development	56
Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis	56
Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration	55
High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae	55
ESCRT-III/Vps4 Controls Heterochromatin-Nuclear Envelope Attachments	55
Harnessing Mechanobiology for Tissue Engineering	54
Glutamine Metabolism Controls Chondrocyte Identity and Function	53
α-tubulin tail modifications regulate microtubule stability through selective effector recruitment, not changes in intrinsic polymer dynamics	53
Phase Separation in Germ Cells and Development	52
A human breast atlas integrating single-cell proteomics and transcriptomics	52
Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?	52
The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth	51
Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis	51
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population	51
Diverse Routes toward Early Somites in the Mouse Embryo	51
CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies	50
N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation	49
Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells	49
Transnitrosylation Mediated by the Non-canonical Catalase ROG1 Regulates Nitric Oxide Signaling in Plants	49
Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production	48
Physical properties of the cytoplasm modulate the rates of microtubule polymerization and depolymerization	48
The Dynein Adaptor RILP Controls Neuronal Autophagosome Biogenesis, Transport, and Clearance	48
Single-cell analysis of human testis aging and correlation with elevated body mass index	48
Lineage-Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis	47
Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation	47
Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells	47
WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues	47
Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo	47
Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis	47
Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation	47
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle	47
Membrane receptor-mediated mechano-transduction maintains cell integrity during pollen tube growth within the pistil	46
Global mapping of glycosylation pathways in human-derived cells	46
Tether Me, Tether Me Not—Dynamic Organelle Contact Sites in Metabolic Rewiring	46
Hyperinsulinemia Drives Epithelial Tumorigenesis by Abrogating Cell Competition	46
VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites	46
Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation	46
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma	45
A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase	45
ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion	45
Metabolic Cellular Communications: Feedback Mechanisms between Membrane Lipid Homeostasis and Plant Development	45
A Weak Link with Actin Organizes Tight Junctions to Control Epithelial Permeability	44
The structure and spontaneous curvature of clathrin lattices at the plasma membrane	44
The central moTOR of metabolism	44
Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes	44
Subcellular coordination of plant cell wall synthesis	44
Embryonic Stem Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK	44
Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites	44
Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand	44
Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational Modifications	43
ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression	42
A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord	42
Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands	42
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C	42
Spatial transcriptional mapping of the human nephrogenic program	41
Genetic variation associated with condensate dysregulation in disease	41
A switch in pdgfrb cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord	40

RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development	40
Tissue-Scale Mechanical Coupling Reduces Morphogenetic Noise to Ensure Precision during Epithelial Folding	40
Distinct Cation Gradients Power Cholesterol Transport at Different Key Points in the Hedgehog Signaling Pathway	40
Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting	40
The Perinuclear ER Scales Nuclear Size Independently of Cell Size in Early Embryos	39
Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition	39
LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force	39
Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry	39
Smooth Muscle Differentiation Is Essential for Airway Size, Tracheal Cartilage Segmentation, but Dispensable for Epithelial Branching	39
Beyond PROX1: transcriptional, epigenetic, and noncoding RNA regulation of lymphatic identity and function	39
Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model	39
Diversity of developing peripheral glia revealed by single-cell RNA sequencing	39
Biomolecular Condensates and Gene Activation in Development and Disease	39
Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration	38
Homology-directed repair protects the replicating genome from metabolic assaults	38
Messenger RNA 5′ NAD+ Capping Is a Dynamic Regulatory Epitranscriptome Mark That Is Required for Proper Response to Abscisic Acid in Arabidopsis	38
Reprogramming Axial Level Identity to Rescue Neural-Crest-Related Congenital Heart Defects	38
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner	38
Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates	38
Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage	38
Localized EMT reprograms glial progenitors to promote spinal cord repair	38
Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment	38
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia	37
Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids	37
A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation	37
Oncogene-regulated release of extracellular vesicles	37
Compartmentalization of telomeres through DNA-scaffolded phase separation	37
Rapid Homeostatic Turnover of Embryonic ECM during Tissue Morphogenesis	37
Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling	37
Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation	37
A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control	37
A reflux-and-growth mechanism explains oscillatory patterning of lateral root branching sites	36
Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation	36
Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration	36
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity	35
Combinatorial Action of Temporally Segregated Transcription Factors	35
Scaling a Dpp Morphogen Gradient through Feedback Control of Receptors and Co-receptors	34
Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration	34
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK	34
Reprogrammed lipid metabolism protects inner nuclear membrane against unsaturated fat	34
The spatiotemporal dynamics of microglia across the human lifespan	33
Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages	33
Peroxisome Elevation Induces Stem Cell Differentiation and Intestinal Epithelial Repair	33
iPSC-derived myelinoids to study myelin biology of humans	33
HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence	33
An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans	32
Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging	32
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence	32
A Ca2+-sensor switch for tolerance to elevated salt stress in Arabidopsis	32
Phase Separation—A Physical Mechanism for Organizing Information and Biochemical Reactions	32
Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics	31
Mechanobiology of the Mitotic Spindle	31
Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis Signaling	31
Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells	31
Autophagy promotes cell survival by maintaining NAD levels	31
Abscission Couples Cell Division to Embryonic Stem Cell Fate	31
Transient Nodal Signaling in Left Precursors Coordinates Opposed Asymmetries Shaping the Heart Loop	30
Plant glutamate receptors mediate a bet-hedging strategy between regeneration and defense	30
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy	30
Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice	30
Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans	30
Metabolic plasticity drives development during mammalian embryogenesis	30
Tumor-induced disruption of the blood-brain barrier promotes host death	30
Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration	29
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N-methyladenosine	29
Cell Junction Mechanics beyond the Bounds of Adhesion and Tension	29
FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity	29
Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation	29
Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition	29
Opposing motors provide mechanical and functional robustness in the human spindle	29
A potassium-sensing niche in Arabidopsis roots orchestrates signaling and adaptation responses to maintain nutrient homeostasis	29
Mechanical feedback defines organizing centers to drive digit emergence	29
Gene regulatory networks shape developmental plasticity of root cell types under water extremes in rice	28
Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice	28
De novo endocytic clathrin coats develop curvature at early stages of their formation	28
Heart regeneration: 20 years of progress and renewed optimism	28
PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation	28
Cytoplasm’s Got Moves	28
Motor usage imprints microtubule stability along the shaft	28
External Mechanical Cues Reveal a Katanin-Independent Mechanism behind Auxin-Mediated Tissue Bending in Plants	28
Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease	28
DNA Helicase Mph1FANCM Ensures Meiotic Recombination between Parental Chromosomes by Dissociating Precocious Displacement Loops	28
Coordinate regulation of the senescent state by selective autophagy	28
Maintaining the structural and functional homeostasis of the plant endoplasmic reticulum	28
The Mitotic Crosslinking Protein PRC1 Acts Like a Mechanical Dashpot to Resist Microtubule Sliding	27
Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects	27
PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay	27
3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels	27
Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements	27
Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment	27
Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung	27
A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors	27
Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration	27
CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling	26
Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion	26