Developmental Cell

Article	Citations
Thriving under Stress: How Plants Balance Growth and the Stress Response	394
Lipid metabolism in cancer: New perspectives and emerging mechanisms	302
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation	263
Distinct contributions of partial and full EMT to breast cancer malignancy	230
Quality control of the mitochondrion	222
Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn’s Disease	207
A Single-Cell Transcriptomic Atlas of Human Skin Aging	191
A single-cell analysis of the Arabidopsis vegetative shoot apex	185
Surviving and thriving: How plants perceive and respond to temperature stress	166
A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants	164
Single-cell RNA sequencing of developing maize ears facilitates functional analysis and trait candidate gene discovery	153
Niches that regulate stem cells and hematopoiesis in adult bone marrow	152
Single-cell resolution of lineage trajectories in the Arabidopsis stomatal lineage and developing leaf	147
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies	132
ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress	131
Lipid metabolism and lipid signals in aging and longevity	130
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C	124
Mechanical Adaptability of Tumor Cells in Metastasis	124
Autophagy and organelle homeostasis in cancer	119
Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy	119
The single-cell stereo-seq reveals region-specific cell subtypes and transcriptome profiling in Arabidopsis leaves	118
Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family	110
Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival	99
Enhancer grammar in development, evolution, and disease: dependencies and interplay	92
Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy	91

Early human embryonic development: Blastocyst formation to gastrulation	90
Tissue mechanics in stem cell fate, development, and cancer	89
Diverse nitrogen signals activate convergent ROP2-TOR signaling in Arabidopsis	89
Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells	89
S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity	88
A census of the lung: CellCards from LungMAP	87
N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles	86
Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis	86
Extracellular vesicles: Critical players during cell migration	85
Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy	84
High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae	83
Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro	83
Fibroblast dedifferentiation as a determinant of successful regeneration	81
Physical properties of the cytoplasm modulate the rates of microtubule polymerization and depolymerization	80
Single-cell analysis of human testis aging and correlation with elevated body mass index	80
ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD	79
Next-Generation Lineage Tracing and Fate Mapping to Interrogate Development	77
Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring	76
The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells	75
Durotaxis: The Hard Path from In Vitro to In Vivo	73
A BIN2-GLK1 Signaling Module Integrates Brassinosteroid and Light Signaling to Repress Chloroplast Development in the Dark	73
Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis	71
Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination	71
Actin-Membrane Release Initiates Cell Protrusions	71
Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation	70
Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications	70
Mechanics of Development	69
3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain	68
Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis	67
Global and Site-Specific Effect of Phosphorylation on Protein Turnover	67
A human breast atlas integrating single-cell proteomics and transcriptomics	67
Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease	67
ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression	67
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population	66
Harnessing Mechanobiology for Tissue Engineering	66
Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production	65
A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver	64
VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites	63
Subcellular coordination of plant cell wall synthesis	62
The central moTOR of metabolism	62
Global mapping of glycosylation pathways in human-derived cells	61
Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage	61
N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation	60
Diverse Routes toward Early Somites in the Mouse Embryo	60
α-tubulin tail modifications regulate microtubule stability through selective effector recruitment, not changes in intrinsic polymer dynamics	60
A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase	60
The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth	59
ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion	59
Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation	59
Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites	59

Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes	58
A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord	56
Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation	55
Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration	55
WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues	55
The structure and spontaneous curvature of clathrin lattices at the plasma membrane	54
The spatiotemporal dynamics of microglia across the human lifespan	54
Diversity of developing peripheral glia revealed by single-cell RNA sequencing	53
Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration	52
LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force	52
Membrane receptor-mediated mechano-transduction maintains cell integrity during pollen tube growth within the pistil	52
Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition	52
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C	51
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner	51
Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics	50
Compartmentalization of telomeres through DNA-scaffolded phase separation	50
Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation	49
RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development	49
A switch in pdgfrb cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord	49
Embryonic Stem Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK	49
Localized EMT reprograms glial progenitors to promote spinal cord repair	49
Spatial transcriptional mapping of the human nephrogenic program	48
Genetic variation associated with condensate dysregulation in disease	47
Lineage-Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis	47
A Ca2+-sensor switch for tolerance to elevated salt stress in Arabidopsis	46
Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry	45
iPSC-derived myelinoids to study myelin biology of humans	45
GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis	44
Heart regeneration: 20 years of progress and renewed optimism	44
Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation	44
Homology-directed repair protects the replicating genome from metabolic assaults	43
Metabolic plasticity drives development during mammalian embryogenesis	43
Messenger RNA 5′ NAD+ Capping Is a Dynamic Regulatory Epitranscriptome Mark That Is Required for Proper Response to Abscisic Acid in Arabidopsis	43
Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids	43
A reflux-and-growth mechanism explains oscillatory patterning of lateral root branching sites	43
Autophagy promotes cell survival by maintaining NAD levels	42
Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability	42
Beyond PROX1: transcriptional, epigenetic, and noncoding RNA regulation of lymphatic identity and function	42
Oncogene-regulated release of extracellular vesicles	42
Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling	41
A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control	41
Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection	41
The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology	41
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity	41
Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages	40
Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration	40
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK	40
Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging	40
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N-methyladenosine	39
The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma	39
Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation	39
Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans	38
Coordinate regulation of the senescent state by selective autophagy	38
Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition	38
Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans	38
An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans	37
Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain	37
Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice	37
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence	37
Developmental landscape of human forebrain at a single-cell level identifies early waves of oligodendrogenesis	37
FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity	37
Reprogrammed lipid metabolism protects inner nuclear membrane against unsaturated fat	37
Plant glutamate receptors mediate a bet-hedging strategy between regeneration and defense	37
Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells	37
Lipid metabolism in adaptation to extreme nutritional challenges	36
Motor usage imprints microtubule stability along the shaft	36
Molecular and spatial landmarks of early mouse skin development	35
Mechanobiology of the Mitotic Spindle	35
A potassium-sensing niche in Arabidopsis roots orchestrates signaling and adaptation responses to maintain nutrient homeostasis	35
Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease	35
Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice	35
Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state	35
Gene regulatory networks shape developmental plasticity of root cell types under water extremes in rice	35
Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration	35
Tumor-induced disruption of the blood-brain barrier promotes host death	35
Mechanical feedback defines organizing centers to drive digit emergence	34
Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis	34
Maintaining the structural and functional homeostasis of the plant endoplasmic reticulum	34
Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements	34
Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development	34

Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue	33
Adaptable P body physical states differentially regulate bicoid mRNA storage during early Drosophila development	33
Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells	32
A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors	32
Homeostatic Regulation of ROS-Triggered Hippo-Yki Pathway via Autophagic Clearance of Ref(2)P/p62 in the Drosophila Intestine	32
Cell Junction Mechanics beyond the Bounds of Adhesion and Tension	32
Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion	32
Deceleration of the cell cycle underpins a switch from proliferative to terminal divisions in plant stomatal lineage	32
Opposing motors provide mechanical and functional robustness in the human spindle	32
Adaptive differentiation promotes intestinal villus recovery	31
Genome-wide analysis of pseudogenes reveals HBBP1’s human-specific essentiality in erythropoiesis and implication in β-thalassemia	31
Acute brain vascular regeneration occurs via lymphatic transdifferentiation	31
Mechanistic connections between mitochondrial biology and regulated cell death	31
Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation	31
External Mechanical Cues Reveal a Katanin-Independent Mechanism behind Auxin-Mediated Tissue Bending in Plants	31
3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels	31
Cytoplasm’s Got Moves	31
Localized glucose import, glycolytic processing, and mitochondria generate a focused ATP burst to power basement-membrane invasion	31
De novo endocytic clathrin coats develop curvature at early stages of their formation	31
Establishment of the vertebrate body plan: Rethinking gastrulation through stem cell models of early embryogenesis	31
A HD-ZIP transcription factor specifies fates of multicellular trichomes via dosage-dependent mechanisms in tomato	30
Root twisting drives halotropism via stress-induced microtubule reorientation	30
PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay	30
Mechanical conflict caused by a cell-wall-loosening enzyme activates de novo shoot regeneration	30
Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression	30
RNA N6-methyladenosine modification promotes auxin biosynthesis required for male meiosis in rice	30
Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes	29
De novo generation of macrophage from placenta-derived hemogenic endothelium	29
Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD	29
Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells	29
A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies	29
The role of senescence in cellular plasticity: Lessons from regeneration and development and implications for age-related diseases	29
piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development	29
Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration	29
Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans	28
Developmental angiocrine diversification of endothelial cells for organotypic regeneration	28
Mechanistic insights into actin force generation during vesicle formation from cryo-electron tomography	28
Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin	28
Notch signaling induces either apoptosis or cell fate change in multiciliated cells during mucociliary tissue remodeling	28
Tumor-derived MMPs regulate cachexia in a Drosophila cancer model	28
Sulfenylation of ENOLASE2 facilitates H2O2-conferred freezing tolerance in Arabidopsis	28
Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells	28
PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport	28
Rapid and efficient degradation of endogenous proteins in vivo identifies stage-specific roles of RNA Pol II pausing in mammalian development	27
RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis	27
A G protein-coupled receptor-like module regulates cellulose synthase secretion from the endomembrane system in Arabidopsis	27
Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis	27
A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids	26
A two-tier junctional mechanism drives simultaneous tissue folding and extension	26
H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity	26
Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice	26
Distinct classes of lagging chromosome underpin age-related oocyte aneuploidy in mouse	26
RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness	26
Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies	26
Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection	26
KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling	26
Directed cell invasion and asymmetric adhesion drive tissue elongation and turning in C. elegans gonad morphogenesis	25
Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation	25
The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation	25
Rapid and robust optogenetic control of gene expression in Drosophila	25
A single-cell transcriptomic inventory of murine smooth muscle cells	25
SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport	25
Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients	24
A metabolic daylength measurement system mediates winter photoperiodism in plants	24
Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing	24
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility	24
Regulation of ARGONAUTE10 Expression Enables Temporal and Spatial Precision in Axillary Meristem Initiation in Arabidopsis	24
Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1	24
Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization	24
Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles	24
Partial EMT takes the lead in cancer metastasis	24
Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model	24
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells	24
Lipolysis-derived linoleic acid drives beige fat progenitor cell proliferation	23
Exocytosis by vesicle crumpling maintains apical membrane homeostasis during exocrine secretion	23
Coupled oscillators coordinate collective germline growth	23
Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth	23
Arp2/3-dependent mechanical control of morphogenetic robustness in an inherently challenging environment	23
Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation	23
Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase	23
Inherited nuclear pore substructures template post-mitotic pore assembly	23
YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth	23
A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion	23
Filament-guided filament assembly provides structural memory of filament alignment during cytokinesis	23
Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis	23
Apical Relaxation during Mitotic Rounding Promotes Tension-Oriented Cell Division	23
Endothelial and Leptin Receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow	23
Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle	23
Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells	23
Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption	23
Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq	23
Formation and function of the meningeal arachnoid barrier around the developing mouse brain	23
Separase cleaves the kinetochore protein Meikin at the meiosis I/II transition	23
FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma	22
Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing	22