Developmental Cell

Article	Citations
Thriving under Stress: How Plants Balance Growth and the Stress Response	359
Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force	299
Lipid metabolism in cancer: New perspectives and emerging mechanisms	282
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation	263
Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates	214
Distinct contributions of partial and full EMT to breast cancer malignancy	208
Quality control of the mitochondrion	205
Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn’s Disease	199
A single-cell analysis of the Arabidopsis vegetative shoot apex	178
A Single-Cell Transcriptomic Atlas of Human Skin Aging	172
Niches that regulate stem cells and hematopoiesis in adult bone marrow	152
A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants	151
Single-cell RNA sequencing of developing maize ears facilitates functional analysis and trait candidate gene discovery	150
Surviving and thriving: How plants perceive and respond to temperature stress	148
Single-cell resolution of lineage trajectories in the Arabidopsis stomatal lineage and developing leaf	147
Cellular Mechanisms and Regulation of Quiescence	143
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies	132
Lipid metabolism and lipid signals in aging and longevity	130
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C	124
Mechanical Adaptability of Tumor Cells in Metastasis	124
ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress	123
Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy	119
The single-cell stereo-seq reveals region-specific cell subtypes and transcriptome profiling in Arabidopsis leaves	118
Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains	106
Autophagy and organelle homeostasis in cancer	104

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family	103
The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana	100
Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival	99
Emerging Roles for Phase Separation in Plants	96
Enhancer grammar in development, evolution, and disease: dependencies and interplay	92
Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy	91
Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells	89
Tissue mechanics in stem cell fate, development, and cancer	89
S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity	88
A census of the lung: CellCards from LungMAP	86
Diverse nitrogen signals activate convergent ROP2-TOR signaling in Arabidopsis	86
N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles	86
Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy	84
Liquid-Liquid Phase Separation in Neuronal Development and Synaptic Signaling	84
Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro	83
Early human embryonic development: Blastocyst formation to gastrulation	83
Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis	80
Extracellular vesicles: Critical players during cell migration	79
Fibroblast dedifferentiation as a determinant of successful regeneration	79
ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD	79
Next-Generation Lineage Tracing and Fate Mapping to Interrogate Development	77
High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae	76
Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring	76
Physical properties of the cytoplasm modulate the rates of microtubule polymerization and depolymerization	75
Durotaxis: The Hard Path from In Vitro to In Vivo	73
Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo	72
The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells	72
Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos	72
Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination	71
Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics	71
Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis	71
Actin-Membrane Release Initiates Cell Protrusions	71
A BIN2-GLK1 Signaling Module Integrates Brassinosteroid and Light Signaling to Repress Chloroplast Development in the Dark	70
Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications	70
Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation	70
Mechanics of Development	69
3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain	68
Single-cell analysis of human testis aging and correlation with elevated body mass index	68
Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease	67
ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression	67
A human breast atlas integrating single-cell proteomics and transcriptomics	67
Global and Site-Specific Effect of Phosphorylation on Protein Turnover	67
Harnessing Mechanobiology for Tissue Engineering	66
Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production	65
A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver	64
Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis	63
VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites	63
Subcellular coordination of plant cell wall synthesis	62
The central moTOR of metabolism	62
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population	62

Global mapping of glycosylation pathways in human-derived cells	61
α-tubulin tail modifications regulate microtubule stability through selective effector recruitment, not changes in intrinsic polymer dynamics	60
N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation	60
Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation	59
Phase Separation in Germ Cells and Development	59
ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion	59
The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth	59
Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes	58
Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells	57
Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand	57
Diverse Routes toward Early Somites in the Mouse Embryo	57
A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase	56
A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord	56
Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites	55
WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues	55
Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation	55
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle	54
The structure and spontaneous curvature of clathrin lattices at the plasma membrane	54
Diversity of developing peripheral glia revealed by single-cell RNA sequencing	53
Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production	52
Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration	52
Membrane receptor-mediated mechano-transduction maintains cell integrity during pollen tube growth within the pistil	52
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C	51
Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation	51
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner	51
Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage	51
LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force	51
Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics	50
Compartmentalization of telomeres through DNA-scaffolded phase separation	50
A switch in pdgfrb cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord	49
Embryonic Stem Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK	49
Localized EMT reprograms glial progenitors to promote spinal cord repair	49
Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation	49
Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition	49
Spatial transcriptional mapping of the human nephrogenic program	48
Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration	48
The spatiotemporal dynamics of microglia across the human lifespan	48
Genetic variation associated with condensate dysregulation in disease	47
Lineage-Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis	47
Biomolecular Condensates and Gene Activation in Development and Disease	46
iPSC-derived myelinoids to study myelin biology of humans	45
Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry	45
RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development	45
Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation	44
A Ca2+-sensor switch for tolerance to elevated salt stress in Arabidopsis	44
Heart regeneration: 20 years of progress and renewed optimism	44
A reflux-and-growth mechanism explains oscillatory patterning of lateral root branching sites	43
Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids	43
Homology-directed repair protects the replicating genome from metabolic assaults	43
Oncogene-regulated release of extracellular vesicles	42
Distinct Cation Gradients Power Cholesterol Transport at Different Key Points in the Hedgehog Signaling Pathway	42
Beyond PROX1: transcriptional, epigenetic, and noncoding RNA regulation of lymphatic identity and function	42
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity	41
A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control	41
Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling	41
Messenger RNA 5′ NAD+ Capping Is a Dynamic Regulatory Epitranscriptome Mark That Is Required for Proper Response to Abscisic Acid in Arabidopsis	41
Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging	40
Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration	40
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK	40
Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages	40
Metabolic plasticity drives development during mammalian embryogenesis	39
Abscission Couples Cell Division to Embryonic Stem Cell Fate	39
Autophagy promotes cell survival by maintaining NAD levels	39
The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma	39
Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition	38
GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis	38
Transient Nodal Signaling in Left Precursors Coordinates Opposed Asymmetries Shaping the Heart Loop	38
Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans	38
A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation	38
Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability	38
Coordinate regulation of the senescent state by selective autophagy	38
Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation	38
Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans	38
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence	37
Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice	37
Reprogrammed lipid metabolism protects inner nuclear membrane against unsaturated fat	37
Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells	37
An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans	37
Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain	37
Combinatorial Action of Temporally Segregated Transcription Factors	36

Motor usage imprints microtubule stability along the shaft	36
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N-methyladenosine	36
Plant glutamate receptors mediate a bet-hedging strategy between regeneration and defense	36
Gene regulatory networks shape developmental plasticity of root cell types under water extremes in rice	35
Mechanobiology of the Mitotic Spindle	35
A potassium-sensing niche in Arabidopsis roots orchestrates signaling and adaptation responses to maintain nutrient homeostasis	35
Tumor-induced disruption of the blood-brain barrier promotes host death	35
The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology	35
Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection	35
Developmental landscape of human forebrain at a single-cell level identifies early waves of oligodendrogenesis	35
FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity	35
Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease	35
Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung	35
Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration	35
Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state	35
Mechanical feedback defines organizing centers to drive digit emergence	34
Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development	34
Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis	34
Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice	34
Lipid metabolism in adaptation to extreme nutritional challenges	34
Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements	34
Maintaining the structural and functional homeostasis of the plant endoplasmic reticulum	34
Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue	33
Adaptable P body physical states differentially regulate bicoid mRNA storage during early Drosophila development	33
Phase Separation—A Physical Mechanism for Organizing Information and Biochemical Reactions	33
Cell Junction Mechanics beyond the Bounds of Adhesion and Tension	32
Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion	32
Opposing motors provide mechanical and functional robustness in the human spindle	32
Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells	32
A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors	32
Cytoplasm’s Got Moves	31
External Mechanical Cues Reveal a Katanin-Independent Mechanism behind Auxin-Mediated Tissue Bending in Plants	31
Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment	31
3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels	31
Adaptive differentiation promotes intestinal villus recovery	31
De novo endocytic clathrin coats develop curvature at early stages of their formation	31
Acute brain vascular regeneration occurs via lymphatic transdifferentiation	31
Mechanistic connections between mitochondrial biology and regulated cell death	31
Localized glucose import, glycolytic processing, and mitochondria generate a focused ATP burst to power basement-membrane invasion	31
Genome-wide analysis of pseudogenes reveals HBBP1’s human-specific essentiality in erythropoiesis and implication in β-thalassemia	31
Mechanical conflict caused by a cell-wall-loosening enzyme activates de novo shoot regeneration	30
PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay	30
Root twisting drives halotropism via stress-induced microtubule reorientation	30
Homeostatic Regulation of ROS-Triggered Hippo-Yki Pathway via Autophagic Clearance of Ref(2)P/p62 in the Drosophila Intestine	30
Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression	30
Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes	29
RNA N6-methyladenosine modification promotes auxin biosynthesis required for male meiosis in rice	29
Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration	29
Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD	29
Deceleration of the cell cycle underpins a switch from proliferative to terminal divisions in plant stomatal lineage	29
De novo generation of macrophage from placenta-derived hemogenic endothelium	29
The role of senescence in cellular plasticity: Lessons from regeneration and development and implications for age-related diseases	29
piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development	29
A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies	29
Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans	28
A HD-ZIP transcription factor specifies fates of multicellular trichomes via dosage-dependent mechanisms in tomato	28
Mechanistic insights into actin force generation during vesicle formation from cryo-electron tomography	28
The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis	28
Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin	28
Developmental angiocrine diversification of endothelial cells for organotypic regeneration	28
Tumor-derived MMPs regulate cachexia in a Drosophila cancer model	28
Establishment of the vertebrate body plan: Rethinking gastrulation through stem cell models of early embryogenesis	28
Notch signaling induces either apoptosis or cell fate change in multiciliated cells during mucociliary tissue remodeling	28
PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport	28
RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis	27
A G protein-coupled receptor-like module regulates cellulose synthase secretion from the endomembrane system in Arabidopsis	27
Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells	27
Rapid and efficient degradation of endogenous proteins in vivo identifies stage-specific roles of RNA Pol II pausing in mammalian development	27
Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis	27
Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation	26
Distinct classes of lagging chromosome underpin age-related oocyte aneuploidy in mouse	26
RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness	26
A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids	26
Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection	26
KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling	26
Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice	26
A two-tier junctional mechanism drives simultaneous tissue folding and extension	26
H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity	26
A single-cell transcriptomic inventory of murine smooth muscle cells	25
SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport	25
Directed cell invasion and asymmetric adhesion drive tissue elongation and turning in C. elegans gonad morphogenesis	25
Rapid and robust optogenetic control of gene expression in Drosophila	25
The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation	25
Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated Cells	25
Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model	24
Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles	24
Regulation of ARGONAUTE10 Expression Enables Temporal and Spatial Precision in Axillary Meristem Initiation in Arabidopsis	24
Sulfenylation of ENOLASE2 facilitates H2O2-conferred freezing tolerance in Arabidopsis	24
Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells	24
Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients	24
The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction	24
Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia	24
Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility	24
Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation	24
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells	24