Nature Immunology

(The TQCC of Nature Immunology is 68. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage1362
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19823
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade788
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry547
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19411
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction378
The immune cell landscape in kidneys of patients with lupus nephritis361
Targeting immune cell circuits and trafficking in inflammatory bowel disease283
Mechanisms of immunotherapy resistance: lessons from glioblastoma272
Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection271
The biology and functional importance of MAIT cells257
m6A modification controls the innate immune response to infection by targeting type I interferons240
Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups236
Innate immunity to intracellular LPS231
Interferon target-gene expression and epigenomic signatures in health and disease228
Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways224
The influence of the microbiome on respiratory health217
Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation217
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion198
The establishment of resident memory B cells in the lung requires local antigen encounter193
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression191
IL-17 receptor–based signaling and implications for disease171
The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum170
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance169
Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses157
Regulation of cGAS- and RLR-mediated immunity to nucleic acids154
Immunological impact of cell death signaling driven by radiation on the tumor microenvironment148
Human CD8+ T cell cross-reactivity across influenza A, B and C viruses148
House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation145
Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation135
Flip the coin: IL-7 and IL-7R in health and disease132
G3BP1 promotes DNA binding and activation of cGAS132
Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses130
Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage129
DEL-1 promotes macrophage efferocytosis and clearance of inflammation128
Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal127
Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells126
Thymic regulatory T cells arise via two distinct developmental programs126
Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage125
CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment121
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation121
Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation117
Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing115
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth113
IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3113
Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation111
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity111
The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response108
Humanized immune system mouse models: progress, challenges and opportunities106
c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies106
Epigenetic programming underpins B cell dysfunction in human SLE103
The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation103
Memory CD4+ T cells are generated in the human fetal intestine103
Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues103
The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity102
Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance101
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity100
Regulatory T cell adaptation in the intestine and skin98
c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis97
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape91
TSLP: from allergy to cancer88
Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration88
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity88
Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children87
Functional reprogramming of regulatory T cells in the absence of Foxp386
Mechanosensing through immunoreceptors85
The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc83
Metabolic adaptations of tissue-resident immune cells81
Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation81
γδ TCR ligands: the quest to solve a 500-million-year-old mystery80
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses80
Adaptation and memory in immune responses78
Locally instructed CXCR4hi neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps78
N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation77
Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM175
The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells75
Cryptic activation of an Irf8 enhancer governs cDC1 fate specification73
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection72
B cell signaling in context72
The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity72
Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer71
An essential role for the Zn2+ transporter ZIP7 in B cell development71
Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease69
Vaccine hesitancy and coercion: all eyes on France68