OOIR: Observatory of International Research

Papers

(The TQCC of Nature Immunology is 68. The table below lists those papers that are above that threshold based on CrossRef citation counts. The publications cover those that have been published in the past four years, i.e., from 2019-03-01 to 2023-03-01.)

Article	Citations
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage	1362
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19	823
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade	788
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry	547
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19	411
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction	378
The immune cell landscape in kidneys of patients with lupus nephritis	361
Targeting immune cell circuits and trafficking in inflammatory bowel disease	283
Mechanisms of immunotherapy resistance: lessons from glioblastoma	272
Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection	271
The biology and functional importance of MAIT cells	257
m6A modification controls the innate immune response to infection by targeting type I interferons	240
Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups	236
Innate immunity to intracellular LPS	231
Interferon target-gene expression and epigenomic signatures in health and disease	228
Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways	224
The influence of the microbiome on respiratory health	217
Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation	217
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion	198
The establishment of resident memory B cells in the lung requires local antigen encounter	193
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression	191
IL-17 receptor–based signaling and implications for disease	171
The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum	170
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance	169
Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses	157
Regulation of cGAS- and RLR-mediated immunity to nucleic acids	154
Immunological impact of cell death signaling driven by radiation on the tumor microenvironment	148
Human CD8+ T cell cross-reactivity across influenza A, B and C viruses	148
House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation	145
Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation	135
Flip the coin: IL-7 and IL-7R in health and disease	132
G3BP1 promotes DNA binding and activation of cGAS	132
Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses	130
Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage	129
DEL-1 promotes macrophage efferocytosis and clearance of inflammation	128
Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal	127
Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells	126
Thymic regulatory T cells arise via two distinct developmental programs	126
Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage	125
CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment	121
Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation	121
Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation	117
Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing	115
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth	113
IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3	113
Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation	111
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity	111
The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response	108
Humanized immune system mouse models: progress, challenges and opportunities	106
c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies	106
Epigenetic programming underpins B cell dysfunction in human SLE	103
The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation	103
Memory CD4+ T cells are generated in the human fetal intestine	103
Subsets of ILC3−ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues	103
The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity	102
Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance	101
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity	100
Regulatory T cell adaptation in the intestine and skin	98
c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis	97
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape	91
TSLP: from allergy to cancer	88
Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration	88
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity	88
Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children	87
Functional reprogramming of regulatory T cells in the absence of Foxp3	86
Mechanosensing through immunoreceptors	85
The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc	83
Metabolic adaptations of tissue-resident immune cells	81
Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation	81
γδ TCR ligands: the quest to solve a 500-million-year-old mystery	80
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses	80
Adaptation and memory in immune responses	78
Locally instructed CXCR4hi neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps	78
N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation	77
Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1	75
The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells	75
Cryptic activation of an Irf8 enhancer governs cDC1 fate specification	73
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection	72
B cell signaling in context	72
The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity	72
Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer	71
An essential role for the Zn2+ transporter ZIP7 in B cell development	71
Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease	69
Vaccine hesitancy and coercion: all eyes on France	68