Nature Immunology

Article	Citations
Vaccine-induced memory	1034
Pathogenic T cells in post-viral lung disease in mice	835
The delivery device of SARS-CoV-2 mucosal vaccine matters	701
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	528
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	471
Charting granulopoietic disturbances in sepsis	464
Ironman training for NK cells	460
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	376
Complement profile	357
Imprinting tissue immunity	353
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	322
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	321
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	298
Keeping neonatal intestines happy	272
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	259
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	227
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat	201
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	193
The complexity of immune evasion mechanisms throughout the metastatic cascade	186
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	172
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	169
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	169
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	168
Lactation-associated macrophages exist in murine mammary tissue and human milk	166
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	165

Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	164
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	161
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	157
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	154
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	152
CTLA-4 tail fusion enhances CAR-T antitumor immunity	150
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	147
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	146
Defective fibrinolysis in periodontitis	145
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	143
KEAP1 maintains stemness	139
Reversing T cell immunity reveals the basis for T cell lineage fate determination	138
Restriction factor	137
Nociceptors enhance humoral immunity	137
Illuminating the nervous system to treat colitis	135
A polarizing answer — microglia in Nasu-Hakola disease	134
CAR macrophages on a fast track to solid tumor therapy	132
G-CSF drives autoinflammation in APLAID	132
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	132
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	131
A microbial iron fist to fight tumors	131
The road not taken en route to T cell exhaustion	130
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	129
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	128
Enhancing T cell therapy	127
Insights into autoimmunity and cancer	125
m1A tRNA modification facilitates rapid T cell proliferation	124
Learning from inborn errors	123
Aging lymph node responses	122
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	121
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	121
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	120
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	119
JAK-STAT signaling maintains homeostasis in T cells and macrophages	118
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	116
Aging disrupts circadian gene regulation and function in macrophages	115
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	115
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	115
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	112
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	108
Defining macrophages in the lactating murine mammary gland and human milk	107
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	107
Mucus needs GSDMD	106
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	105
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	105
Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection	104
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	104
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	103
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	102
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	99

Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	97
Low-avidity T cells drive endogenous tumor immunity in mice and humans	95
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	94
Transcriptional state and function of CD8+ memory T cells is linked to past proliferation	93
What Jane Jacobs has taught me about neuroimmunology	91
Three cytokine pairs modulate sepsis effects at the organism level	90
Less BMI-1 is more for chronic infections	88
Role of the T cell vitamin D receptor in severe COVID-19	87
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	86
Reply to ‘Comment on: Repositioning TH cell polarization from single cytokines to complex help’	86
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	84
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	84
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity	84
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	84
Distinct developmental pathways generate functionally distinct populations of natural killer cells	83
Mapping the interferon response	82
Meningeal damage repair	82
Mouse long-lived plasma cells develop from multiple origins	81
HSCs perpetuate inflammation	81
Unraveling age-specific complexity in the human T cell compartment	81
Pregnancy stress	80
Gasdermin splicing	79
Facilitating broad antibody responses	79
B cells require exosomes	79
Itaconate modifies JAK1	78
Mentorship matters	77
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	76
Gut Treg cells release IL-27 to regulate TH17 cell responses	76
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	75
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	75
Germinal centers FAMished without TFAM	74
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	73
COQ6 defies immune and metabolic expectations	72
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	72
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	72
Diversity in science requires mentoring for all, by all	71
Neuropilin-1 flags lung-resident type 2 innate lymphoid cells	71
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	70
Multitier mechanics control stromal adaptations in the swelling lymph node	70
c-Myb redefines the hierarchy of stem-like T cells	70
Specialization determines outcomes in inflammation and cancer	70
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	69
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	67
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	67
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	67
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8+ T cells	66
Significance of bystander T cell activation in microbial infection	66
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	65
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection	65
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	65
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses	65
A second-generation M1-polarized CAR macrophage with antitumor efficacy	64
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	64
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	63
Inflammasome protein scaffolds the DNA damage complex during tumor development	63
Notch gives early T cell progenitors time to grow up	63
TFH cell responses endure in human lymph nodes after vaccination	63
COVID-19 vaccine trials must include helminth-infected cohorts	63
Human SHARPIN deficiency is linked to inborn errors of cell death	63
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	63
Stress-induced inflammation	61
lnc(RNA)-ing myeloid metabolism	61
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19	60
Monocytes can proliferate in vacant niches before differentiation into macrophages	60
Anti-tumor CTLs need IL-27	60
Recycling dead bacteria to fuel macrophage immunometabolism	60
Brain hematopoiesis	60
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	58
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	57
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	57
Heads or tails: histone tail clipping regulates macrophage activity	57
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	57
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells	56
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	56
m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	56
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	56
Time is of the essence for vaccine success	55
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	55
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	55
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	55

β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	55
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	54
An updated guide for the perplexed: cytometry in the high-dimensional era	54
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	54
Frank W. Fitch (1929–2021)	53
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	53
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	53
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition	53
The immunoregulatory landscape of human tuberculosis granulomas	53
The cellular architecture of the antimicrobial response network in human leprosy granulomas	53
Inflammatory fibroblasts remodeling in colitis	52
Systems neuroimmunology: current bottlenecks, research priorities and future directions	52
PD-L1 senses fungi	52
Old and new mpox vaccine	52
A CRISPR-based system for temporal, combinatorial gene knockout in mice	52
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	52
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	52
Author Correction: Elusive early NK cell progenitor identified	52
PD-1 blockade unblocks immune responses to vaccination	51
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	51
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	51
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	51
The hidden functional diversity of macrophages	51
cGAS meets its demise in the nucleus	50
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	50
Advancements in pathogen immunity and signaling	49
Reactivating antitumor immunity by inhibiting JMJD1C	49
Unveiling the antitumor function of ID3 in liver macrophages	49
The embers underneath the CoV-2 pandemic: a semblance of the persistent burn of health inequities and disparities in the United States	49
Stress and immunity — the circuit makes the difference	48
ImmGenMaps, an open-source cartography of the immune system	48
The humoral response and antibodies against SARS-CoV-2 infection	48
IFNλ drives diarrhea	48
An anion channel for cyclic dinucleotides in T cells	48
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	47
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	47
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	47
TH17 cell heterogeneity and its role in tissue inflammation	47
Thioredoxin is a metabolic rheostat controlling regulatory B cells	47
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	47
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations	46
Mechanism for controlled assembly of transcriptional condensates by Aire	46
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	46
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	46
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	45
TCF-1 mediates chromatin intermingling during T cell development	45
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	45
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	45
Natural mouse microbes transiently block innate responses to allergens	44
Two CTLA-4 ligands, separate pHates	44
Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion	44
High energy, high function	44
Mitochondria controls TH17 cells	44
Check(point) yourself before you wreck yourself in tumors	43
Plasmacytoid dendritic cells turn red!	43
Modulating RNF41	43
Stuart Schlossman (1935–2023)	43
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	43
T cells drive aging of the brain	43
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	43
SLE B cells take an extrafollicular detour after mRNA vaccination	43
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	42
IL-1α in aging tumors	42
Past interactions of T cells with antigens shape CAR T cell responses	42
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	41
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs	41
OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity	41
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases	41
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	40
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	40
Distinct metabolic requirements regulate B cell activation and germinal center responses	40
Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer	40
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	38
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	38
Innate lymphoid cells and cancer	38
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	38
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	38
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape	37
Macrophages set the bar for acute pain sensitivity	36
A protective ACPA	36
Hallmarks of T cell aging	36
Reactivity to type I interferon is key to predict cancer immunotherapy response	36
Immunological imprinting and risks of influenza B virus infection	35
Immune-mediated inflammation across disease boundaries: breaking down research silos	35
Common heritage of fibroblasts	35
Author Correction: Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota	35
Tracing the origins of lung fibrosis	34
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa	34
Hidden in plain sight: uncovering the role of CREB1 in HIV-1 vaccine-induced immunity	34
Long COVID	34
A balancing act in the control of self-antigen expression	34
Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors	34
Controlling TRM differentiation	34
CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology	33
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation	33