Nature Immunology

Papers
(The TQCC of Nature Immunology is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19979
The T cell immune response against SARS-CoV-2762
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function708
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation539
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19530
Single-cell landscape of immunological responses in patients with COVID-19485
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection459
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition441
Immunogenic cell stress and death422
NLRP3 inflammasome in cancer and metabolic diseases421
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies410
Pathological sequelae of long-haul COVID388
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison374
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum372
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion355
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection354
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines351
Innate immunity: the first line of defense against SARS-CoV-2291
The immunology of rheumatoid arthritis291
Autoimmunity and organ damage in systemic lupus erythematosus282
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection276
Climate change: an enduring challenge for vector-borne disease prevention and control266
Trained immunity, tolerance, priming and differentiation: distinct immunological processes265
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion244
The RNA modification N6-methyladenosine as a novel regulator of the immune system242
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies234
Extracellular vesicles in immunomodulation and tumor progression227
Proinflammatory IgG Fc structures in patients with severe COVID-19226
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen222
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons220
Microglia use TAM receptors to detect and engulf amyloid β plaques220
PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer215
Mapping systemic lupus erythematosus heterogeneity at the single-cell level212
Hallmarks of T cell aging210
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy210
ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection191
The complex role of tumor-infiltrating macrophages185
Redox homeostasis maintained by GPX4 facilitates STING activation182
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance182
Lymph node stromal cells: cartographers of the immune system181
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity180
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine177
Novel Hexb-based tools for studying microglia in the CNS177
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms175
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines167
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells165
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity163
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor162
The mesenchymal context in inflammation, immunity and cancer160
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans160
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity154
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis154
Early precursor T cells establish and propagate T cell exhaustion in chronic infection154
Establishment of an African green monkey model for COVID-19 and protection against re-infection147
Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal144
Environmental pollutants and the immune response142
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells142
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection138
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity138
A new neutrophil subset promotes CNS neuron survival and axon regeneration137
Sestrins induce natural killer function in senescent-like CD8+ T cells136
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis124
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans122
Regulation and modulation of antitumor immunity in pancreatic cancer121
Dynamics in protein translation sustaining T cell preparedness119
Neuroinflammation after surgery: from mechanisms to therapeutic targets116
Does tissue imprinting restrict macrophage plasticity?115
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation115
Inflammasomes and adaptive immune responses115
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity111
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression111
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes110
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity110
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung109
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation109
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation107
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells107
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses107
The immunoregulatory landscape of human tuberculosis granulomas107
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells107
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease106
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection106
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape105
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis104
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells103
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation102
Immunology of SARS-CoV-2 infection in children99
The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development97
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens97
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma95
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection95
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules94
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments94
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity94
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-1993
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects91
Immune cell compartmentalization for brain surveillance and protection89
Repositioning TH cell polarization from single cytokines to complex help89
The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin87
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs87
Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis85
Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity84
The humoral response and antibodies against SARS-CoV-2 infection82
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly82
Inefficient CAR-proximal signaling blunts antigen sensitivity81
Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection81
Remodeling of light and dark zone follicular dendritic cells governs germinal center responses80
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection80
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments80
Distinct transcription factor networks control neutrophil-driven inflammation79
Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits79
STEEP mediates STING ER exit and activation of signaling79
Epigenetic regulation of T cell exhaustion78
Lessons learned: new insights on the role of cytokines in COVID-1977
Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling76
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection76
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression76
BATF3 programs CD8+ T cell memory75
Delayed-interval BNT162b2 mRNA COVID-19 vaccination enhances humoral immunity and induces robust T cell responses75
Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation74
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states74
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells73
The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge72
Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection72
Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors70
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals70
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-1969
Transmission of trained immunity and heterologous resistance to infections across generations69
Innate lymphoid cells and cancer68
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity68
PERK is a critical metabolic hub for immunosuppressive function in macrophages68
Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis68
Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin67
Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function66
Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria65
A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma65
The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate65
Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands63
Human immune diversity: from evolution to modernity63
Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells63
Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung62
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory62
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes62
IRGM1 links mitochondrial quality control to autoimmunity62
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics60
Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity60
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes60
Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation59
Novel specialized cell state and spatial compartments within the germinal center59
Significance of bystander T cell activation in microbial infection59
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins58
Superior immunogenicity and effectiveness of the third compared to the second BNT162b2 vaccine dose58
The cellular architecture of the antimicrobial response network in human leprosy granulomas58
Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation58
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity58
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization57
Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication57
Heme catabolism by tumor-associated macrophages controls metastasis formation56
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy56
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation55
T cells in COVID-19 — united in diversity55
Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity55
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer55
IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation55
Functional CRISPR dissection of gene networks controlling human regulatory T cell identity55
Eomes identifies thymic precursors of self-specific memory-phenotype CD8+ T cells55
Naturalizing mouse models for immunology54
Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition54
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting54
Aging disrupts circadian gene regulation and function in macrophages54
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation53
Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques53
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells52
Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues52
The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides52
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease52
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity52
Fibroblasts as a source of self-antigens for central immune tolerance52
The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic–epigenetic reprogramming and resolves inflammatory injury51
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation51
A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes51
RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus51
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses51
γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis51
ImmGen at 1550
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress50
The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection50
Microbial metabolism of l-tyrosine protects against allergic airway inflammation49
Tissue adaptation and clonal segregation of human memory T cells in barrier sites48
Making innate sense of mRNA vaccine adjuvanticity48
mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates47
SARS-CoV-2 takes its Toll46
Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis–like disease and inflammation46
Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses46
Divergent clonal differentiation trajectories of T cell exhaustion45
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection45
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat45
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity44
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity44
Dynamic regulation of B cell complement signaling is integral to germinal center responses44
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues43
Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory43
Cascading risks of waterborne diseases from climate change43
Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities42
Surface phenotypes of naive and memory B cells in mouse and human tissues42
Circadian clocks guide dendritic cells into skin lymphatics42
Environmental allergens trigger type 2 inflammation through ripoptosome activation42
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway42
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation42
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells42
Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development42
The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis41
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B41
Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion41
Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome41
Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells41
Chd4 choreographs self-antigen expression for central immune tolerance41
The molecular basis underpinning the potency and specificity of MAIT cell antigens40
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling40
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations39
BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S239
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory39
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination39
TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer39
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development39
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory39
An updated guide for the perplexed: cytometry in the high-dimensional era39
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection39
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer39
Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes38
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses38
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy38
Early emergence of T central memory precursors programs clonal dominance during chronic viral infection37
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation37
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-1937
Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression37
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells37
Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis37
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation36
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine36
Neutrophils direct preexisting matrix to initiate repair in damaged tissues36
High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells36
TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis36
An engineered bispecific human monoclonal antibody against SARS-CoV-236
Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies36
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis35
Distinct changes in endosomal composition promote NLRP3 inflammasome activation35
In situ neutrophil efferocytosis shapes T cell immunity to influenza infection35
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis35
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course35
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