Nature Immunology

Article	Citations
Vaccine-induced memory	780
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	688
Complement profile	321
Imprinting tissue immunity	321
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	318
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	304
Pathogenic T cells in post-viral lung disease in mice	262
TFH cell programs by pathogen and species	262
Neurons protect against fibrosis	262
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	258
Ironman training for NK cells	254
CD8+ TRM cells and lung epithelial cells crosstalk	239
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	239
Zika immune imprint risks dengue	231
A little less reading, a little more type 9 action	226
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	223
Charting granulopoietic disturbances in sepsis	211
The delivery device of SARS-CoV-2 mucosal vaccine matters	211
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	208
Secretogranin 2 binds LILRB4 resulting in immunosuppression	206
CTLA-4 tail fusion enhances CAR-T antitumor immunity	199
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	198
Astrocyte TRAIL promotes GBM	193
Inhibition of salt-inducible kinases reprograms T cells and antitumor immunity in ovarian cancer	188
Lactation-associated macrophages exist in murine mammary tissue and human milk	185

A TNIP1-driven systemic autoimmune disorder with elevated IgG4	180
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	177
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	164
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	163
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	163
Lymphocyte-derived cholinergic circuits modulate germinal center output and B cell activation	163
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	162
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	160
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	158
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	158
Keeping neonatal intestines happy	150
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	146
The complexity of immune evasion mechanisms throughout the metastatic cascade	144
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	142
Nociceptors enhance humoral immunity	141
Restriction factor	140
m1A tRNA modification facilitates rapid T cell proliferation	137
Enhancing T cell therapy	132
Insights into autoimmunity and cancer	129
The road not taken en route to T cell exhaustion	124
Microglia loss triggers glial stress and white matter damage in human leukodystrophy	123
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	120
Learning from inborn errors	120
KEAP1 maintains stemness	118
Carboxylation switch	116
A polarizing answer — microglia in Nasu-Hakola disease	115
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	114
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription	114
Active aldehydes drive metabolic exhaustion in CD8+ T cells	114
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	113
A microbial iron fist to fight tumors	113
G-CSF drives autoinflammation in APLAID	112
Stemness for HIV control	110
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	109
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	108
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity	106
Beneficial role of GZMK+CD8+ T cells in neurodegeneration	106
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	105
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	104
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	102
Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	102
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	101
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	100
Enzymatic cleavage weaponizes bacterial lipoproteins into immune tripwires	100
Six degrees of TGFβ	100
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	99
CAR macrophages on a fast track to solid tumor therapy	98
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	94
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	94
Costimulation drives CAR-T cell division fate	93

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	92
JAK-STAT signaling maintains homeostasis in T cells and macrophages	91
Defining macrophages in the lactating murine mammary gland and human milk	90
Three cytokine pairs modulate sepsis effects at the organism level	90
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis	90
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	90
Breastfeeding induces protective T cells	89
What Jane Jacobs has taught me about neuroimmunology	89
Band-Aid for antibody production	87
Author Correction: A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity	87
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	87
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	86
LPS structure shapes Treg cells	86
Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332gp120 glycan-independent epitope	85
Distinct developmental pathways generate functionally distinct populations of natural killer cells	85
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	85
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	84
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	84
2B or not 2B is the question in DC ontogeny	83
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets	82
Low-avidity T cells drive endogenous tumor immunity in mice and humans	81
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	81
A temporal map of B cell diversification mechanisms in mice	81
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	81
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	79
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate	79
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	78
Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases	78
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	77
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	76
Unraveling age-specific complexity in the human T cell compartment	75
Pregnancy stress	75
Mouse long-lived plasma cells develop from multiple origins	75
Gasdermin splicing	74
Meningeal damage repair	73
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	73
Germinal centers FAMished without TFAM	73
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	72
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	71
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	71
Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease	70
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	70
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	70
COQ6 defies immune and metabolic expectations	70
Facilitating broad antibody responses	68
c-Myb redefines the hierarchy of stem-like T cells	68
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	68
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	67
Author Correction: Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	66
TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size	66
DC subsets and states unraveled across human juxtatumoral and malignant tissues	66
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	66
Progress on the pathway to long COVID treatments	65
Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy	65
The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer	65
Pyoderma gangrenosum caused by the molecular uncoupling of OTULIN catalytic activity and LUBAC binding	65
Multitier mechanics control stromal adaptations in the swelling lymph node	65
Gut Treg cells release IL-27 to regulate TH17 cell responses	64
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	63
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	63
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	63
A second-generation M1-polarized CAR macrophage with antitumor efficacy	62
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	62
Specialization determines outcomes in inflammation and cancer	62
Notch gives early T cell progenitors time to grow up	60
Human SHARPIN deficiency is linked to inborn errors of cell death	60
lnc(RNA)-ing myeloid metabolism	60
Inflammasome protein scaffolds the DNA damage complex during tumor development	59
Antiphage SIR2 in humans	59
Differential assembly of mouse and human tumor microenvironments	59
Humanized mice for MS studies	59
Monocytes can proliferate in vacant niches before differentiation into macrophages	59
TFH cell responses endure in human lymph nodes after vaccination	59
Engineering Trikines	58
Pro-tumor neural pathways	58
Stress-induced inflammation	58
Towards evidence-based immunology	58
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	58
Anti-tumor CTLs need IL-27	58
Y do T cells fail	58

Author Correction: Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology	57
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	56
m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	56
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	55
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	55
TNF gives plasmacytoid dendritic cells a new life	55
Recycling dead bacteria to fuel macrophage immunometabolism	55
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	55
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	55
Time is of the essence for vaccine success	55
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes	55
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity	54
Thymic alveolar type 2 epithelial mimetic cells revealed by RUNX1 deficiency	54
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	54
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	54
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor	54
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	54
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response	54
Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis	53
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	53
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	53
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	52
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	52
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	52
cGAS meets its demise in the nucleus	51
Short-range immunity	51
The BCR-SEQC initiative	51
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	51
IFNλ drives diarrhea	51
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	51
PD-L1 senses fungi	51
Unveiling the antitumor function of ID3 in liver macrophages	51
Quiet custodians of CD8+ T cell fate	50
Reactivating antitumor immunity by inhibiting JMJD1C	50
A CRISPR-based system for temporal, combinatorial gene knockout in mice	50
David Baltimore (1938–2025)	50
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	50
Systems neuroimmunology: current bottlenecks, research priorities and future directions	49
Inflammatory fibroblasts remodeling in colitis	49
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	49
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	49
Old and new mpox vaccine	49
Retraction Note: Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells	48
Stress and immunity — the circuit makes the difference	48
Distinct spatial organization governs oral mucosal immunity	48
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	48
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	47
Spatial map of microglial diversity beyond proteopathy	47
Advancements in pathogen immunity and signaling	46
Skin–gut crosstalk	46
Charting new territory for T cells in pediatric lupus	46
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	46
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	45
PD-1 blockade unblocks immune responses to vaccination	45
A new ‘K’ind of T helper cell	44
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	44
Author Correction: Elusive early NK cell progenitor identified	44
Thioredoxin is a metabolic rheostat controlling regulatory B cells	44
ImmGenMaps, an open-source cartography of the immune system	44
OXPHOS fuels cDC1s	44
Fed T cells	44
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	43
Inflammatory immune modulators of AML lung infiltration and respiratory failure	43
The hidden functional diversity of macrophages	43
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	43
Sex differences in immune responses to viruses, bacteria and vaccines	43
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis	43
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	43
Adaptive immunity in the pathogenesis of neurodegeneration	43
Microbiota-mediated mechanisms of mucosal immunity across the lifespan	42
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity	42
Mechanism for controlled assembly of transcriptional condensates by Aire	42
TH17 cell heterogeneity and its role in tissue inflammation	42
Mitochondria controls TH17 cells	41
Natural mouse microbes transiently block innate responses to allergens	41
Modulating RNF41	41
Check(point) yourself before you wreck yourself in tumors	41
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	41
Plasmacytoid dendritic cells turn red!	41
Stuart Schlossman (1935–2023)	40
IL-1α in aging tumors	40
Yin and yang of tumor-associated macrophages	40
SLE B cells take an extrafollicular detour after mRNA vaccination	40
Past interactions of T cells with antigens shape CAR T cell responses	40
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	40
Affinity maturation of AAN-I-IFNs	39
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	39
Maternal allergy and infection promote asthma	39
T cells drive aging of the brain	39
T cells in cerebrospinal fluid support a suspected viral link to multiple sclerosis	39
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	39
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis	39
Two CTLA-4 ligands, separate pHates	39
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	38
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	38