Nature Immunology

Article	Citations
Vaccine-induced memory	1121
The delivery device of SARS-CoV-2 mucosal vaccine matters	1070
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	795
Ironman training for NK cells	637
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	570
Keeping neonatal intestines happy	554
Charting granulopoietic disturbances in sepsis	524
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	448
Imprinting tissue immunity	405
Complement profile	392
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	263
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	240
TFH cell programs by pathogen and species	237
A little less reading, a little more type 9 action	233
Pathogenic T cells in post-viral lung disease in mice	224
Neurons protect against fibrosis	219
Astrocyte TRAIL promotes GBM	218
Secretogranin 2 binds LILRB4 resulting in immunosuppression	215
Lactation-associated macrophages exist in murine mammary tissue and human milk	208
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	203
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	198
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	191
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	190
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	188
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	183

Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	182
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	182
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	177
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	176
The complexity of immune evasion mechanisms throughout the metastatic cascade	175
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	175
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	173
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	171
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	170
CTLA-4 tail fusion enhances CAR-T antitumor immunity	170
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	170
Nociceptors enhance humoral immunity	163
Restriction factor	159
Reversing T cell immunity reveals the basis for T cell lineage fate determination	155
m1A tRNA modification facilitates rapid T cell proliferation	152
Enhancing T cell therapy	152
Insights into autoimmunity and cancer	151
Aging lymph node responses	149
Six degrees of TGFβ	148
Defective fibrinolysis in periodontitis	146
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis	146
The road not taken en route to T cell exhaustion	144
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	143
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	139
Microglia loss triggers glial stress and white matter damage in human leukodystrophy	138
Learning from inborn errors	133
CAR macrophages on a fast track to solid tumor therapy	132
Carboxylation switch	129
Beneficial role of GZMK+CD8+ T cells in neurodegeneration	128
Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	127
KEAP1 maintains stemness	125
A polarizing answer — microglia in Nasu-Hakola disease	118
G-CSF drives autoinflammation in APLAID	116
Aging disrupts circadian gene regulation and function in macrophages	115
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription	115
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	115
A microbial iron fist to fight tumors	115
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	114
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	112
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	111
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	108
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	107
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	102
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	100
JAK-STAT signaling maintains homeostasis in T cells and macrophages	100
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	97
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	96
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	95
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity	95
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	94

Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	94
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	92
2B or not 2B is the question in DC ontogeny	91
Defining macrophages in the lactating murine mammary gland and human milk	91
LPS structure shapes Treg cells	91
Mucus needs GSDMD	91
Three cytokine pairs modulate sepsis effects at the organism level	89
Author Correction: A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity	89
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	89
Less BMI-1 is more for chronic infections	88
Role of the T cell vitamin D receptor in severe COVID-19	88
Reply to ‘Comment on: Repositioning TH cell polarization from single cytokines to complex help’	87
What Jane Jacobs has taught me about neuroimmunology	87
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	86
Transcriptional state and function of CD8+ memory T cells is linked to past proliferation	86
Distinct developmental pathways generate functionally distinct populations of natural killer cells	85
Breastfeeding induces protective T cells	85
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate	83
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	83
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	82
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	82
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	81
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets	81
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	79
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	79
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	79
Low-avidity T cells drive endogenous tumor immunity in mice and humans	78
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	78
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	78
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	77
Unraveling age-specific complexity in the human T cell compartment	76
HSCs perpetuate inflammation	75
Pregnancy stress	74
Mouse long-lived plasma cells develop from multiple origins	74
Facilitating broad antibody responses	73
B cells require exosomes	72
Meningeal damage repair	71
Gasdermin splicing	71
The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer	71
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	70
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	69
Germinal centers FAMished without TFAM	69
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	69
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	69
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	68
Specialization determines outcomes in inflammation and cancer	68
Gut Treg cells release IL-27 to regulate TH17 cell responses	68
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	68
Neuropilin-1 flags lung-resident type 2 innate lymphoid cells	68
COQ6 defies immune and metabolic expectations	67
Itaconate modifies JAK1	67
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	66
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	66
c-Myb redefines the hierarchy of stem-like T cells	65
Progress on the pathway to long COVID treatments	65
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	65
Multitier mechanics control stromal adaptations in the swelling lymph node	65
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	65
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	64
Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease	64
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	64
A second-generation M1-polarized CAR macrophage with antitumor efficacy	64
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	64
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	64
lnc(RNA)-ing myeloid metabolism	63
Notch gives early T cell progenitors time to grow up	63
Human SHARPIN deficiency is linked to inborn errors of cell death	62
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	62
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	61
Monocytes can proliferate in vacant niches before differentiation into macrophages	61
TFH cell responses endure in human lymph nodes after vaccination	60
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	60
Antiphage SIR2 in humans	60
Stress-induced inflammation	60
COVID-19 vaccine trials must include helminth-infected cohorts	59
Humanized mice for MS studies	59
Y do T cells fail	58
TNF gives plasmacytoid dendritic cells a new life	58
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor	58
Recycling dead bacteria to fuel macrophage immunometabolism	58

m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	57
Towards evidence-based immunology	57
Inflammasome protein scaffolds the DNA damage complex during tumor development	57
Time is of the essence for vaccine success	57
Anti-tumor CTLs need IL-27	56
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	56
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	56
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity	56
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	55
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition	55
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	55
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	54
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	54
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	54
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	54
The immunoregulatory landscape of human tuberculosis granulomas	54
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	53
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	52
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	52
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	52
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	52
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	52
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response	52
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	51
Author Correction: Elusive early NK cell progenitor identified	51
PD-L1 senses fungi	50
Old and new mpox vaccine	50
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	49
cGAS meets its demise in the nucleus	49
IFNλ drives diarrhea	49
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	49
Short-range immunity	49
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	49
Unveiling the antitumor function of ID3 in liver macrophages	49
Advancements in pathogen immunity and signaling	49
PD-1 blockade unblocks immune responses to vaccination	49
An anion channel for cyclic dinucleotides in T cells	48
A CRISPR-based system for temporal, combinatorial gene knockout in mice	48
Inflammatory fibroblasts remodeling in colitis	48
The BCR-SEQC initiative	48
Stress and immunity — the circuit makes the difference	47
The hidden functional diversity of macrophages	46
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	46
Skin–gut crosstalk	46
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	45
Charting new territory for T cells in pediatric lupus	45
Spatial map of microglial diversity beyond proteopathy	45
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	45
ImmGenMaps, an open-source cartography of the immune system	44
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	44
Mechanism for controlled assembly of transcriptional condensates by Aire	44
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	44
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	43
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	43
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	43
Reactivating antitumor immunity by inhibiting JMJD1C	43
David Baltimore (1938–2025)	43
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity	42
Quiet custodians of CD8+ T cell fate	42
The humoral response and antibodies against SARS-CoV-2 infection	42
Thioredoxin is a metabolic rheostat controlling regulatory B cells	42
Systems neuroimmunology: current bottlenecks, research priorities and future directions	42
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	42
Microbiota-mediated mechanisms of mucosal immunity across the lifespan	41
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	41
Mitochondria controls TH17 cells	41
High energy, high function	41
TH17 cell heterogeneity and its role in tissue inflammation	41
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	41
TCF-1 mediates chromatin intermingling during T cell development	41
Natural mouse microbes transiently block innate responses to allergens	40
Check(point) yourself before you wreck yourself in tumors	40
IL-1α in aging tumors	40
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	40
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	40
Plasmacytoid dendritic cells turn red!	40
Two CTLA-4 ligands, separate pHates	40
Modulating RNF41	40
SLE B cells take an extrafollicular detour after mRNA vaccination	40
Stuart Schlossman (1935–2023)	39
Past interactions of T cells with antigens shape CAR T cell responses	39
LARP4-mediated hypertranslation drives T cell dysfunction in tumors	39
VDAC2 enforces a mitochondrial checkpoint to cancer immunity	39
T cells drive aging of the brain	38
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	38
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	38
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	38
Intestinal neuron-associated macrophages in health and disease	38
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	37
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	37
Distinct metabolic requirements regulate B cell activation and germinal center responses	37
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis	37
Innate lymphoid cells and cancer	37
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases	37
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	37