Nature Immunology

Article	Citations
Glucocorticoids initiate regulatory T cell and stem-cell crosstalk to grow new hair	955
Long-term study of the human memory B cell pool reveals high stability and recurrent plasmablasts	683
Inflammatory macrophages	625
Thomas Alexander Waldmann (1930–2021)	607
Bound to be perfect: Lck and T cell co-receptors	477
Cancer immunology leads the way	438
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs	412
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	374
Mellower with age	324
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	315
Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function	295
Excess lipids on endosomes dictate NLRP3 localization and inflammasome activation	288
Distinct metabolic requirements regulate B cell activation and germinal center responses	278
Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach	278
Innate lymphoid cells and cancer	268
pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells	261
Check(point) yourself before you wreck yourself in tumors	248
Dangerous liaisons	228
Sensing DCs	224
Epigenetic checkpoints regulate the fate and function of CAR-T cells	196
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation	194
Vaccine-induced memory	180
MHC-II heterozygosity limits type 1 diabetes susceptibility through negative selection	167
Mast cell migration and organization in tissues depend on integrin–ECM interactions	159
Promise and complexity of lupus mouse models	153

TCF-1 mediates chromatin intermingling during T cell development	153
Anecdotes from the pandemic	148
High energy, high function	147
Disease trajectories	141
Delivering retinol	137
When ceramides meet immune senescence, a GIMAP5 connection	136
A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity	136
The COVID-19 immunology masterclass enters its fourth year	129
Bispecific antiviral neutralizing antibodies are twice as nice	128
Sex differences are skin deep	128
Mitochondrial dysfunction in the erythroid compartment	127
Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands	127
Genomic map of inflammatory blood proteins	123
Mitochondria controls TH17 cells	122
Imprinting tissue immunity	122
New functions for basophils identified in kidney fibrosis	121
Human and mouse peritoneal macrophages and dendritic cells compared	120
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	118
The delivery device of SARS-CoV-2 mucosal vaccine matters	116
Inflammatory blood clots	115
Genomic map of the cellular composition of the tumor microenvironment	114
Recreating immune and epithelial interactions in organoids	113
Modulating RNF41	113
Working towards diversity in the immunology research community	109
CD8+ TRM cells in perpetual motion	108
CTLA-4 nanobody stops colitis	104
Antigen-presenting CAFs	102
Creating ATP via creatine kinase B for NLRP3 activation	101
Resident memory T cells develop regional dialects	100
Viral protein activates the NLRP1 inflammasome	100
Maladaptive consequences of inflammatory events shape individual immune identity	99
Stepwise chromatin and transcriptional acquisition of an intraepithelial lymphocyte program	99
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	98
Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans	97
Editorial Expression of Concern: The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin	97
Plasmacytoid dendritic cells turn red!	97
T cell exhaustion—a memory locked behind scars	94
Keeping neonatal intestines happy	94
Functional T cell tolerance by peripheral tissue-based checkpoint control	93
Gene-by-environment regulation of Kupffer cell transcriptomes and epigenomes	92
Natural mouse microbes transiently block innate responses to allergens	92
Immunological signature	91
Regulators of placental antibody transfer through a modeling lens	91
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	91
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases	90
IL-1α in aging tumors	90
Pathogenic T cells in post-viral lung disease in mice	89
Weak enhancer allows autoactivation of Irf8 to control cDC1 versus cDC2 lineage commitment	87
Itaconate isomers add complexity	85
Two CTLA-4 ligands, separate pHates	85

Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells	84
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat	83
New fibroblast network connections support lymphocytic cellular service	82
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	82
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	81
Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche	79
100 years of antibody solitude in TB	78
PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells	78
Modulating bone marrow niches	76
Tpt1 the balance toward immunosuppression upon cell death	75
Fructose sweetens antitumor responses	74
Stuart Schlossman (1935–2023)	74
A common activator of tissue-remodeling fibroblasts across tissues	74
Spatial proteomics of tumor microenvironments reveal why location matters	74
A nasal vaccine elicits protective CD8+ T cell immunity against antigen shifted SARS-CoV-2 virus	73
Complement profile	73
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	72
Immunity after SARS-CoV-2 infections	72
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	71
Ironman training for NK cells	71
Trained immunity across organs	70
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity	70
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia	69
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	69
BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin	68
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	68
Living the SARS-CoV-2 pandemic in Turkey	67
Hallmarks of T cell aging	66
Extracellular vesicles in immunomodulation and tumor progression	65
Inflammasomes and adaptive immune responses	65
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology	65
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells	65
Nurture over nature for old antitumor T cells	64
CTLA-4 tail fusion enhances CAR-T antitumor immunity	64
Wnt–β-catenin as an epigenetic switcher in colonic Treg cells	63
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	63
Apoptotic contraction drives target cell release by cytotoxic T cells	62
Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function	62
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	61
OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity	61
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape	61
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	61
FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells	61
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system	60
Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy	60
Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families	60
T cells drive aging of the brain	59
Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis	57
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	57
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	56
KSHV-encoded ORF45 activates human NLRP1 inflammasome	55
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation	55
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer	55
Mitochondrial damage activates the NLRP10 inflammasome	54
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	54
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics	53
Pyroptotic corpses are flagged by filopodia to alert dendritic cells	53
Defining blood-induced microglia functions in neurodegeneration through multiomic profiling	53
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	53
Divergent clonal differentiation trajectories of T cell exhaustion	53
Past interactions of T cells with antigens shape CAR T cell responses	53
The T cell immune response against SARS-CoV-2	52
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination	52
Affinity gaps among B cells in germinal centers drive the selection of MPER precursors	52
The complexity of immune evasion mechanisms throughout the metastatic cascade	52
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation	52
SLE B cells take an extrafollicular detour after mRNA vaccination	52
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity	51
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation	51
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans	51
Nociceptor-immune interactomes reveal insult-specific immune signatures of pain	50
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	50
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity	49
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity	49
From denial to hope: Brazil deals with a prolonged COVID-19 epidemic course	49
Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis	49
Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion	48
Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses	48
tRNA methylation — a new level of control for T cell immunity	48
The Immunological Proteome Resource	47

Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression	47
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	47
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course	47
Microbiota shape tumor immunity	47
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	46
Mechanisms of myeloid cell entry to the healthy and diseased central nervous system	46
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity	46
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease	46
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection	45
Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts	45
Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles	45
The neuroimmunology of social-stress-induced sensitization	44
Lactation-associated macrophages exist in murine mammary tissue and human milk	44
Distinct changes in endosomal composition promote NLRP3 inflammasome activation	44
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	44
PI16+ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches	44
SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses	43
Heme catabolism by tumor-associated macrophages controls metastasis formation	43
Decoding the tumor microenvironment with spatial technologies	43
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	43
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation	43
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	43
Multimodal single-cell datasets characterize antigen-specific CD8+ T cells across SARS-CoV-2 vaccination and infection	42
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	42
Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade	42
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints	42
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance	42
ZBTB46 coordinates angiogenesis and immunity to control tumor outcome	41
Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease	41
TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases	41
Author Correction: Molecular mechanisms of lineage decisions in metabolite-specific T cells	40
Author Correction: Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection	40
Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation	40
Author Correction: Macrophage function in adipose tissue homeostasis and metabolic inflammation	40
ILC1s control leukemia stem cell fate and limit development of AML	40
Publisher Correction: Fiber-poor Western diets fuel inflammation	40
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	39
Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets	39
Author Correction: Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development	39
Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation	39
Charting granulopoietic disturbances in sepsis	39
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	38
Publisher Correction: Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	38
Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir	38
Next-generation combination approaches for immune checkpoint therapy	38
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	38
Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction	38
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	38
NIAID workshop on T cell technologies	37
Macrophage function in adipose tissue homeostasis and metabolic inflammation	37
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	37
Author Correction: T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control	37
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation	36
Transmission of trained immunity and heterologous resistance to infections across generations	36
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences	36
Author Correction: Selenium–GPX4 axis protects follicular helper T cells from ferroptosis	36
Inflating the role of stromal cells in CD8+ T cell memory	36
Reply to: ‘Lack of evidence for intergenerational inheritance of immune resistance to infections’	36
Publisher Correction: Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2	36
Anti-fungal role for type I IFN as dectin-1 triggers non-pathogenic TH17 cell development	36
New Zealand’s science-led response to the SARS-CoV-2 pandemic	35
Human immune diversity: from evolution to modernity	35
Tipping the balance in CD4+ T cells	35
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation	34
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	34
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	34
Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge	33
Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses	33
ImmunOctoberfest reloaded	33
Single-cell profiling of the immune landscape across the human lifespan	33
The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity	33
Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity	33
Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses	33
Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses	32
Lack of evidence for intergenerational inheritance of immune resistance to infections	31
Macrophages set the bar for acute pain sensitivity	30
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy	30
An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells	30
The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state	30
γδ stress detectors	29
A distinct subtype of stromal cell orchestrates the inflammatory response to tissue injury	29
IL-27 gives a good gut feeling about immune regulation	29
Reversing T cell immunity reveals the basis for T cell lineage fate determination	28
Understanding serial killers	28
Mapping brain–immune interactions in ischemic stroke	28
Controlling TRM differentiation	28
Immune imprinting	28
Linking the allergy epidemic to climate change	28
IFN response depletes serotonin	28
Neuroimmunology, women scientists and dogma	28
IL-3 worsens MS	28
Generation of a novel synthetic CD8+ T cell state that leads to tumor control in mice	27
Joost J. Oppenheim (1934–2022)	27
Resilient brains run out of (c)GAS	27
Thymus mimetic cells	27