Nature Immunology

Article	Citations
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19	1013
The T cell immune response against SARS-CoV-2	867
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function	755
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19	557
Immunogenic cell stress and death	531
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection	528
Single-cell landscape of immunological responses in patients with COVID-19	509
NLRP3 inflammasome in cancer and metabolic diseases	506
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies	465
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition	460
Pathological sequelae of long-haul COVID	443
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection	404
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion	404
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison	394
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines	385
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum	384
Innate immunity: the first line of defense against SARS-CoV-2	350
The immunology of rheumatoid arthritis	339
Trained immunity, tolerance, priming and differentiation: distinct immunological processes	307
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection	290
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion	277
Extracellular vesicles in immunomodulation and tumor progression	270
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies	269
The complex role of tumor-infiltrating macrophages	262
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen	259

Hallmarks of T cell aging	249
Microglia use TAM receptors to detect and engulf amyloid β plaques	243
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy	238
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons	232
Mapping systemic lupus erythematosus heterogeneity at the single-cell level	231
Proinflammatory IgG Fc structures in patients with severe COVID-19	229
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance	226
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	219
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity	216
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine	215
ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection	202
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor	190
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity	189
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis	185
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity	184
The mesenchymal context in inflammation, immunity and cancer	178
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells	176
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans	175
Environmental pollutants and the immune response	171
Early precursor T cells establish and propagate T cell exhaustion in chronic infection	169
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells	166
Establishment of an African green monkey model for COVID-19 and protection against re-infection	154
A new neutrophil subset promotes CNS neuron survival and axon regeneration	153
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity	146
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection	145
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans	138
Inflammasomes and adaptive immune responses	135
Dynamics in protein translation sustaining T cell preparedness	135
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation	133
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity	131
Regulation and modulation of antitumor immunity in pancreatic cancer	130
Neuroinflammation after surgery: from mechanisms to therapeutic targets	128
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes	126
The immunoregulatory landscape of human tuberculosis granulomas	125
Does tissue imprinting restrict macrophage plasticity?	125
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation	125
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells	125
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape	122
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression	121
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation	120
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells	120
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung	119
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis	118
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses	117
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity	115
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection	114
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease	113
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments	113
Immunology of SARS-CoV-2 infection in children	112
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells	111

The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens	109
Repositioning TH cell polarization from single cytokines to complex help	109
The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin	107
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules	107
Epigenetic regulation of T cell exhaustion	107
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects	105
Immune cell compartmentalization for brain surveillance and protection	105
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma	104
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments	103
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets	101
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression	101
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection	100
The humoral response and antibodies against SARS-CoV-2 infection	99
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19	98
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states	92
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection	92
STEEP mediates STING ER exit and activation of signaling	91
Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity	89
Innate lymphoid cells and cancer	88
Inefficient CAR-proximal signaling blunts antigen sensitivity	88
Distinct transcription factor networks control neutrophil-driven inflammation	88
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection	87
Delayed-interval BNT162b2 mRNA COVID-19 vaccination enhances humoral immunity and induces robust T cell responses	87
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	86
PERK is a critical metabolic hub for immunosuppressive function in macrophages	85
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells	83
Lessons learned: new insights on the role of cytokines in COVID-19	81
BATF3 programs CD8+ T cell memory	81
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics	80
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	80
Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin	79
Transmission of trained immunity and heterologous resistance to infections across generations	79
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19	78
Human immune diversity: from evolution to modernity	78
Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors	78
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals	76
The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate	73
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity	73
The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge	73
IRGM1 links mitochondrial quality control to autoimmunity	72
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	72
Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function	71
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation	70
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress	70
Superior immunogenicity and effectiveness of the third compared to the second BNT162b2 vaccine dose	70
Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation	69
Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung	69
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis	69
Significance of bystander T cell activation in microbial infection	68
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes	68
Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues	68
Aging disrupts circadian gene regulation and function in macrophages	68
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	68
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation	68
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory	67
Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands	67
A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma	67
IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation	67
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy	67
Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques	66
Heme catabolism by tumor-associated macrophages controls metastasis formation	66
Tissue adaptation and clonal segregation of human memory T cells in barrier sites	66
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	65
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease	64
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory	64
Naturalizing mouse models for immunology	62
Divergent clonal differentiation trajectories of T cell exhaustion	62
Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication	62
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	62
Functional CRISPR dissection of gene networks controlling human regulatory T cell identity	61
The cellular architecture of the antimicrobial response network in human leprosy granulomas	60
RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus	60
The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic–epigenetic reprogramming and resolves inflammatory injury	59
The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection	59
Fibroblasts as a source of self-antigens for central immune tolerance	59
TH17 cell heterogeneity and its role in tissue inflammation	58
T cells in COVID-19 — united in diversity	58
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)	57
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity	57
CD4+ T cell memory	57

γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis	56
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting	56
Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition	56
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses	55
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	55
Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells	55
Circadian clocks guide dendritic cells into skin lymphatics	55
Surface phenotypes of naive and memory B cells in mouse and human tissues	55
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity	55
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat	54
Making innate sense of mRNA vaccine adjuvanticity	54
Microbial metabolism of l-tyrosine protects against allergic airway inflammation	53
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	53
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B	52
YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells	52
Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion	52
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer	52
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	51
The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis	51
Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses	51
Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis	50
Distinct changes in endosomal composition promote NLRP3 inflammasome activation	50
CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	50
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity	50
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway	50
Molecular mechanisms of gasdermin D pore-forming activity	50
Dynamic regulation of B cell complement signaling is integral to germinal center responses	49
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues	49
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation	49
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3	49
Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies	49
LAG-3 as the third checkpoint inhibitor	49
Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome	49
Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression	49
SARS-CoV-2 takes its Toll	48
mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates	48
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	48
Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota	47
Environmental allergens trigger type 2 inflammation through ripoptosome activation	47
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course	47
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells	47
Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis	46
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	46
Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory	46
An engineered bispecific human monoclonal antibody against SARS-CoV-2	45
Macrophage function in adipose tissue homeostasis and metabolic inflammation	45
TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer	45
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses	45
Targeting TFH cells in human diseases and vaccination: rationale and practice	45
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer	45
An updated guide for the perplexed: cytometry in the high-dimensional era	44
Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs	44
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	44
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	43
Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development	43
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	43
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations	42
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development	42
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells	42
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation	42
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection	42
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	42
Neutrophils direct preexisting matrix to initiate repair in damaged tissues	41
BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2	41
High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells	41
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity	40
Early emergence of T central memory precursors programs clonal dominance during chronic viral infection	40
Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche	40
Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes	40
TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis	40
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19	39
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity	39
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	39
A guide to systems-level immunomics	39
Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo	38
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation	38
Deconvoluting global cytokine signaling networks in natural killer cells	38
Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate	38
Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity	38
The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells	38
Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity	38
Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts	38
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures	37
In situ neutrophil efferocytosis shapes T cell immunity to influenza infection	37
Taiwan’s experience in fighting COVID-19	37
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints	37
Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression	36
Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis	36
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences	36
Dichotomous metabolic networks govern human ILC2 proliferation and function	36
A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS	35
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	35
Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2	35
Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children	35
Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation	35