Nature Immunology

(The median citation count of Nature Immunology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19998
The T cell immune response against SARS-CoV-2809
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function733
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation579
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19541
Single-cell landscape of immunological responses in patients with COVID-19499
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection488
Immunogenic cell stress and death474
NLRP3 inflammasome in cancer and metabolic diseases463
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition451
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies438
Pathological sequelae of long-haul COVID408
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison382
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum380
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection377
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion376
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines370
Innate immunity: the first line of defense against SARS-CoV-2328
The immunology of rheumatoid arthritis311
Autoimmunity and organ damage in systemic lupus erythematosus301
Trained immunity, tolerance, priming and differentiation: distinct immunological processes293
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection280
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion263
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies252
Extracellular vesicles in immunomodulation and tumor progression248
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen239
Microglia use TAM receptors to detect and engulf amyloid β plaques234
Hallmarks of T cell aging229
Proinflammatory IgG Fc structures in patients with severe COVID-19228
The complex role of tumor-infiltrating macrophages225
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons223
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy221
Mapping systemic lupus erythematosus heterogeneity at the single-cell level219
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance204
Redox homeostasis maintained by GPX4 facilitates STING activation199
ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection198
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity197
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine193
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines192
Novel Hexb-based tools for studying microglia in the CNS187
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms183
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity177
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor173
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells170
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans169
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity167
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis167
The mesenchymal context in inflammation, immunity and cancer166
Early precursor T cells establish and propagate T cell exhaustion in chronic infection159
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells156
Environmental pollutants and the immune response155
Establishment of an African green monkey model for COVID-19 and protection against re-infection150
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection143
A new neutrophil subset promotes CNS neuron survival and axon regeneration143
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity140
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans132
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis130
Regulation and modulation of antitumor immunity in pancreatic cancer128
Dynamics in protein translation sustaining T cell preparedness127
Inflammasomes and adaptive immune responses125
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity122
Does tissue imprinting restrict macrophage plasticity?121
Neuroinflammation after surgery: from mechanisms to therapeutic targets118
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity117
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation116
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation116
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes116
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression116
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells115
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation114
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses113
The immunoregulatory landscape of human tuberculosis granulomas113
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells113
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung113
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease111
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape110
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells109
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection109
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis108
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens106
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments105
Immunology of SARS-CoV-2 infection in children105
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity104
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules101
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma101
The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development100
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects99
The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin98
Immune cell compartmentalization for brain surveillance and protection97
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection97
Repositioning TH cell polarization from single cytokines to complex help97
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-1996
Epigenetic regulation of T cell exhaustion90
The humoral response and antibodies against SARS-CoV-2 infection89
Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis89
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments88
Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity87
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection87
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression86
Inefficient CAR-proximal signaling blunts antigen sensitivity85
Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits84
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection84
Distinct transcription factor networks control neutrophil-driven inflammation84
STEEP mediates STING ER exit and activation of signaling84
Innate lymphoid cells and cancer83
Remodeling of light and dark zone follicular dendritic cells governs germinal center responses81
Delayed-interval BNT162b2 mRNA COVID-19 vaccination enhances humoral immunity and induces robust T cell responses81
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states80
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells78
Lessons learned: new insights on the role of cytokines in COVID-1977
PERK is a critical metabolic hub for immunosuppressive function in macrophages76
Transmission of trained immunity and heterologous resistance to infections across generations76
BATF3 programs CD8+ T cell memory76
Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection74
Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin74
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals73
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity72
The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge72
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-1972
Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors71
Human immune diversity: from evolution to modernity71
Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria69
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity68
IRGM1 links mitochondrial quality control to autoimmunity68
Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function68
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation67
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics67
Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation67
Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells67
The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate67
Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung66
A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma66
Aging disrupts circadian gene regulation and function in macrophages66
Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands65
Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation64
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes64
Superior immunogenicity and effectiveness of the third compared to the second BNT162b2 vaccine dose63
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory63
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer63
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy63
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins62
Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity62
Significance of bystander T cell activation in microbial infection62
Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues62
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation62
IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation61
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses60
Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity59
Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication59
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization59
Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques59
Functional CRISPR dissection of gene networks controlling human regulatory T cell identity59
Heme catabolism by tumor-associated macrophages controls metastasis formation59
The cellular architecture of the antimicrobial response network in human leprosy granulomas58
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress58
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells58
Naturalizing mouse models for immunology57
Fibroblasts as a source of self-antigens for central immune tolerance57
The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic–epigenetic reprogramming and resolves inflammatory injury57
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation57
T cells in COVID-19 — united in diversity56
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease55
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting55
The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection54
Tissue adaptation and clonal segregation of human memory T cells in barrier sites54
γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis54
Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition54
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity53
RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus53
Microbial metabolism of l-tyrosine protects against allergic airway inflammation53
Divergent clonal differentiation trajectories of T cell exhaustion53
ImmGen at 1552
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory50
Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses50
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets50
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B50
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat50
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection49
Making innate sense of mRNA vaccine adjuvanticity49
Circadian clocks guide dendritic cells into skin lymphatics49
Chd4 choreographs self-antigen expression for central immune tolerance48
mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates48
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway48
Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion47
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis47
SARS-CoV-2 takes its Toll47
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity47
Surface phenotypes of naive and memory B cells in mouse and human tissues47
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity47
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues46
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation46
Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells46
Distinct changes in endosomal composition promote NLRP3 inflammasome activation46
Environmental allergens trigger type 2 inflammation through ripoptosome activation45
Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies45
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses45
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination45
TH17 cell heterogeneity and its role in tissue inflammation45
Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome45
CD4+ T cell memory44
The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis44
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling44
Dynamic regulation of B cell complement signaling is integral to germinal center responses44
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells43
Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory43
TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer43
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses43
An updated guide for the perplexed: cytometry in the high-dimensional era43
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis43
Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development42
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy42
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development42
Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression41
An engineered bispecific human monoclonal antibody against SARS-CoV-240
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory40
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer40
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection40
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)40
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course40
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations40
BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S240
Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis40
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells39
Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota39
Neutrophils direct preexisting matrix to initiate repair in damaged tissues39
Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs39
Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis39
Early emergence of T central memory precursors programs clonal dominance during chronic viral infection39
Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes39
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation38
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation38
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-1938
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine38
High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells38
TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis38
Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate37
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer37
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity37
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG337
Taiwan’s experience in fighting COVID-1937
YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells37
A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections36
Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts36
CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions36
Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis36
Molecular mechanisms of gasdermin D pore-forming activity36
Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity35
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity35
In situ neutrophil efferocytosis shapes T cell immunity to influenza infection35
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity35