Nature Immunology

Article	Citations
Vaccine-induced memory	752
Keeping neonatal intestines happy	675
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	306
Imprinting tissue immunity	305
Complement profile	296
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	287
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	254
Pathogenic T cells in post-viral lung disease in mice	246
Neurons protect against fibrosis	244
TFH cell programs by pathogen and species	244
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	243
Ironman training for NK cells	233
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	230
CD8+ TRM cells and lung epithelial cells crosstalk	223
Zika immune imprint risks dengue	222
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	218
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	217
A little less reading, a little more type 9 action	207
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	205
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	204
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	201
The delivery device of SARS-CoV-2 mucosal vaccine matters	194
Charting granulopoietic disturbances in sepsis	189
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	183
Astrocyte TRAIL promotes GBM	182

Lactation-associated macrophages exist in murine mammary tissue and human milk	181
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	178
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	173
Lymphocyte-derived cholinergic circuits modulate germinal center output and B cell activation	165
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	160
CTLA-4 tail fusion enhances CAR-T antitumor immunity	160
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	155
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	154
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	152
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	152
The complexity of immune evasion mechanisms throughout the metastatic cascade	150
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	148
Secretogranin 2 binds LILRB4 resulting in immunosuppression	146
Inhibition of salt-inducible kinases reprograms T cells and antitumor immunity in ovarian cancer	137
Nociceptors enhance humoral immunity	136
Restriction factor	135
m1A tRNA modification facilitates rapid T cell proliferation	133
Enhancing T cell therapy	132
Insights into autoimmunity and cancer	131
Six degrees of TGFβ	123
The road not taken en route to T cell exhaustion	122
Microglia loss triggers glial stress and white matter damage in human leukodystrophy	121
Learning from inborn errors	118
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	116
Carboxylation switch	114
KEAP1 maintains stemness	114
A polarizing answer — microglia in Nasu-Hakola disease	113
Active aldehydes drive metabolic exhaustion in CD8+ T cells	113
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	112
Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	111
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription	110
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	108
A microbial iron fist to fight tumors	107
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	106
CAR macrophages on a fast track to solid tumor therapy	106
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	106
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis	100
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	100
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	99
G-CSF drives autoinflammation in APLAID	99
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	99
Stemness for HIV control	99
Beneficial role of GZMK+CD8+ T cells in neurodegeneration	98
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	97
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity	97
JAK-STAT signaling maintains homeostasis in T cells and macrophages	96
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	96
Enzymatic cleavage weaponizes bacterial lipoproteins into immune tripwires	93
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	92
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	92

tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	90
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	89
Defining macrophages in the lactating murine mammary gland and human milk	87
Three cytokine pairs modulate sepsis effects at the organism level	86
2B or not 2B is the question in DC ontogeny	86
Band-Aid for antibody production	86
Author Correction: A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity	85
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	85
What Jane Jacobs has taught me about neuroimmunology	85
Breastfeeding induces protective T cells	84
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	83
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets	82
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	82
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	82
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	82
Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332gp120 glycan-independent epitope	81
LPS structure shapes Treg cells	80
Distinct developmental pathways generate functionally distinct populations of natural killer cells	80
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	79
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	79
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	79
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	79
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate	78
Low-avidity T cells drive endogenous tumor immunity in mice and humans	77
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	77
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	76
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	76
Pregnancy stress	75
Mouse long-lived plasma cells develop from multiple origins	75
B cells require exosomes	75
Unraveling age-specific complexity in the human T cell compartment	75
Meningeal damage repair	74
Gasdermin splicing	74
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	73
Germinal centers FAMished without TFAM	73
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	73
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	72
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	72
Specialization determines outcomes in inflammation and cancer	71
COQ6 defies immune and metabolic expectations	71
c-Myb redefines the hierarchy of stem-like T cells	70
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	70
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	70
The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer	69
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	68
Gut Treg cells release IL-27 to regulate TH17 cell responses	68
Multitier mechanics control stromal adaptations in the swelling lymph node	68
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	68
Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease	67
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	67
TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size	66
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	66
Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy	65
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	65
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	65
Progress on the pathway to long COVID treatments	64
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	64
DC subsets and states unraveled across human juxtatumoral and malignant tissues	64
Facilitating broad antibody responses	64
Author Correction: Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	63
A second-generation M1-polarized CAR macrophage with antitumor efficacy	63
Notch gives early T cell progenitors time to grow up	63
Human SHARPIN deficiency is linked to inborn errors of cell death	62
lnc(RNA)-ing myeloid metabolism	62
Monocytes can proliferate in vacant niches before differentiation into macrophages	61
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	61
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	61
Stress-induced inflammation	60
Towards evidence-based immunology	60
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes	59
Anti-tumor CTLs need IL-27	59
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	59
Engineering Trikines	59
Y do T cells fail	58
Pro-tumor neural pathways	58
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	58
Author Correction: Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology	57
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	57
m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	56
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	56

Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	56
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	56
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	56
Recycling dead bacteria to fuel macrophage immunometabolism	56
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition	56
Time is of the essence for vaccine success	55
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	55
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity	54
TNF gives plasmacytoid dendritic cells a new life	54
TFH cell responses endure in human lymph nodes after vaccination	53
Antiphage SIR2 in humans	53
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	53
Humanized mice for MS studies	53
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	53
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	52
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	52
Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis	52
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	52
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response	52
Thymic alveolar type 2 epithelial mimetic cells revealed by RUNX1 deficiency	52
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor	51
Inflammasome protein scaffolds the DNA damage complex during tumor development	51
Short-range immunity	51
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	51
IFNλ drives diarrhea	51
PD-L1 senses fungi	51
Differential assembly of mouse and human tumor microenvironments	51
cGAS meets its demise in the nucleus	51
The BCR-SEQC initiative	50
Unveiling the antitumor function of ID3 in liver macrophages	50
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	50
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	49
Reactivating antitumor immunity by inhibiting JMJD1C	49
Systems neuroimmunology: current bottlenecks, research priorities and future directions	49
A CRISPR-based system for temporal, combinatorial gene knockout in mice	49
David Baltimore (1938–2025)	49
Inflammatory fibroblasts remodeling in colitis	49
Quiet custodians of CD8+ T cell fate	49
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	49
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	49
Retraction Note: Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells	48
Distinct spatial organization governs oral mucosal immunity	48
Old and new mpox vaccine	48
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	47
Stress and immunity — the circuit makes the difference	47
Spatial map of microglial diversity beyond proteopathy	47
Advancements in pathogen immunity and signaling	46
Charting new territory for T cells in pediatric lupus	46
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	46
The hidden functional diversity of macrophages	46
Skin–gut crosstalk	46
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	46
Sex differences in immune responses to viruses, bacteria and vaccines	46
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	45
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	44
PD-1 blockade unblocks immune responses to vaccination	44
ImmGenMaps, an open-source cartography of the immune system	44
Author Correction: Elusive early NK cell progenitor identified	44
Mechanism for controlled assembly of transcriptional condensates by Aire	44
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	43
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	43
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity	43
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis	43
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	43
Microbiota-mediated mechanisms of mucosal immunity across the lifespan	42
TH17 cell heterogeneity and its role in tissue inflammation	42
The humoral response and antibodies against SARS-CoV-2 infection	42
A new ‘K’ind of T helper cell	42
Thioredoxin is a metabolic rheostat controlling regulatory B cells	42
TCF-1 mediates chromatin intermingling during T cell development	41
Mitochondria controls TH17 cells	41
SLE B cells take an extrafollicular detour after mRNA vaccination	40
Check(point) yourself before you wreck yourself in tumors	40
Modulating RNF41	40
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	40
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	40
IL-1α in aging tumors	40
Plasmacytoid dendritic cells turn red!	40
Natural mouse microbes transiently block innate responses to allergens	40
VDAC2 enforces a mitochondrial checkpoint to cancer immunity	39
Maternal allergy and infection promote asthma	39
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	39
Past interactions of T cells with antigens shape CAR T cell responses	39
Yin and yang of tumor-associated macrophages	39
T cells in cerebrospinal fluid support a suspected viral link to multiple sclerosis	39
Stuart Schlossman (1935–2023)	39
Intestinal neuron-associated macrophages in health and disease	39
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	39
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	38
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	38
Two CTLA-4 ligands, separate pHates	38
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis	38
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	37
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	37
T cells drive aging of the brain	37