Nature Immunology

Papers
(The H4-Index of Nature Immunology is 82. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
The T cell immune response against SARS-CoV-2915
Immunogenic cell stress and death610
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection584
NLRP3 inflammasome in cancer and metabolic diseases577
Pathological sequelae of long-haul COVID463
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion442
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines407
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison404
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum396
Innate immunity: the first line of defense against SARS-CoV-2374
The immunology of rheumatoid arthritis366
Trained immunity, tolerance, priming and differentiation: distinct immunological processes335
The complex role of tumor-infiltrating macrophages316
Extracellular vesicles in immunomodulation and tumor progression299
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection295
Hallmarks of T cell aging275
Microglia use TAM receptors to detect and engulf amyloid β plaques265
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance256
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines248
Proinflammatory IgG Fc structures in patients with severe COVID-19246
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine242
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity235
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor212
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity211
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis202
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity196
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells187
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells180
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets167
Establishment of an African green monkey model for COVID-19 and protection against re-infection157
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity153
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection153
Inflammasomes and adaptive immune responses150
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans148
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation147
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity138
Does tissue imprinting restrict macrophage plasticity?137
The immunoregulatory landscape of human tuberculosis granulomas137
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation136
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells134
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes132
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells130
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape129
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments125
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells125
Immunology of SARS-CoV-2 infection in children122
Epigenetic regulation of T cell exhaustion122
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection122
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity122
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression120
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease118
Repositioning TH cell polarization from single cytokines to complex help116
Immune cell compartmentalization for brain surveillance and protection115
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma114
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens113
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments113
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules109
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects108
The humoral response and antibodies against SARS-CoV-2 infection108
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection106
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19104
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity103
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states103
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics99
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection99
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection97
Distinct transcription factor networks control neutrophil-driven inflammation97
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation97
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells96
PERK is a critical metabolic hub for immunosuppressive function in macrophages95
Delayed-interval BNT162b2 mRNA COVID-19 vaccination enhances humoral immunity and induces robust T cell responses94
Innate lymphoid cells and cancer92
Human immune diversity: from evolution to modernity90
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)90
Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors87
Transmission of trained immunity and heterologous resistance to infections across generations87
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses86
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer86
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity85
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-1983
Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin83
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation83
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress82
CD4+ T cell memory82
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation82
0.10340595245361