OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Immunology is 91. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19	1013
The T cell immune response against SARS-CoV-2	867
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function	755
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19	557
Immunogenic cell stress and death	531
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection	528
Single-cell landscape of immunological responses in patients with COVID-19	509
NLRP3 inflammasome in cancer and metabolic diseases	506
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies	465
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition	460
Pathological sequelae of long-haul COVID	443
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection	404
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion	404
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison	394
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines	385
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum	384
Innate immunity: the first line of defense against SARS-CoV-2	350
The immunology of rheumatoid arthritis	339
Trained immunity, tolerance, priming and differentiation: distinct immunological processes	307
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection	290
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion	277
Extracellular vesicles in immunomodulation and tumor progression	270
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies	269
The complex role of tumor-infiltrating macrophages	262
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen	259

Hallmarks of T cell aging	249
Microglia use TAM receptors to detect and engulf amyloid β plaques	243
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy	238
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons	232
Mapping systemic lupus erythematosus heterogeneity at the single-cell level	231
Proinflammatory IgG Fc structures in patients with severe COVID-19	229
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance	226
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	219
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity	216
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine	215
ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection	202
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor	190
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity	189
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis	185
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity	184
The mesenchymal context in inflammation, immunity and cancer	178
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells	176
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans	175
Environmental pollutants and the immune response	171
Early precursor T cells establish and propagate T cell exhaustion in chronic infection	169
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells	166
Establishment of an African green monkey model for COVID-19 and protection against re-infection	154
A new neutrophil subset promotes CNS neuron survival and axon regeneration	153
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity	146
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection	145
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans	138
Dynamics in protein translation sustaining T cell preparedness	135
Inflammasomes and adaptive immune responses	135
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation	133
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity	131
Regulation and modulation of antitumor immunity in pancreatic cancer	130
Neuroinflammation after surgery: from mechanisms to therapeutic targets	128
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes	126
The immunoregulatory landscape of human tuberculosis granulomas	125
Does tissue imprinting restrict macrophage plasticity?	125
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation	125
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells	125
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape	122
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression	121
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells	120
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation	120
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung	119
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis	118
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses	117
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity	115
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection	114
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments	113
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease	113
Immunology of SARS-CoV-2 infection in children	112
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells	111

The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens	109
Repositioning TH cell polarization from single cytokines to complex help	109
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules	107
Epigenetic regulation of T cell exhaustion	107
The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin	107
Immune cell compartmentalization for brain surveillance and protection	105
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects	105
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma	104
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments	103
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets	101
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression	101
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection	100
The humoral response and antibodies against SARS-CoV-2 infection	99
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19	98
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection	92
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states	92
STEEP mediates STING ER exit and activation of signaling	91