Nature Immunology

(The H4-Index of Nature Immunology is 92. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19998
The T cell immune response against SARS-CoV-2809
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function733
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation579
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19541
Single-cell landscape of immunological responses in patients with COVID-19499
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection488
Immunogenic cell stress and death474
NLRP3 inflammasome in cancer and metabolic diseases463
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition451
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies438
Pathological sequelae of long-haul COVID408
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison382
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum380
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection377
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion376
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines370
Innate immunity: the first line of defense against SARS-CoV-2328
The immunology of rheumatoid arthritis311
Autoimmunity and organ damage in systemic lupus erythematosus301
Trained immunity, tolerance, priming and differentiation: distinct immunological processes293
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection280
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion263
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies252
Extracellular vesicles in immunomodulation and tumor progression248
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen239
Microglia use TAM receptors to detect and engulf amyloid β plaques234
Hallmarks of T cell aging229
Proinflammatory IgG Fc structures in patients with severe COVID-19228
The complex role of tumor-infiltrating macrophages225
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons223
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy221
Mapping systemic lupus erythematosus heterogeneity at the single-cell level219
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance204
Redox homeostasis maintained by GPX4 facilitates STING activation199
ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection198
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity197
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine193
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines192
Novel Hexb-based tools for studying microglia in the CNS187
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms183
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity177
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor173
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells170
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans169
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity167
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis167
The mesenchymal context in inflammation, immunity and cancer166
Early precursor T cells establish and propagate T cell exhaustion in chronic infection159
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells156
Environmental pollutants and the immune response155
Establishment of an African green monkey model for COVID-19 and protection against re-infection150
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection143
A new neutrophil subset promotes CNS neuron survival and axon regeneration143
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity140
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans132
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis130
Regulation and modulation of antitumor immunity in pancreatic cancer128
Dynamics in protein translation sustaining T cell preparedness127
Inflammasomes and adaptive immune responses125
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity122
Does tissue imprinting restrict macrophage plasticity?121
Neuroinflammation after surgery: from mechanisms to therapeutic targets118
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity117
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation116
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation116
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes116
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression116
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells115
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation114
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung113
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses113
The immunoregulatory landscape of human tuberculosis granulomas113
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells113
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease111
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape110
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection109
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells109
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis108
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens106
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments105
Immunology of SARS-CoV-2 infection in children105
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity104
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules101
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma101
The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development100
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects99
The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin98
Repositioning TH cell polarization from single cytokines to complex help97
Immune cell compartmentalization for brain surveillance and protection97
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection97
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-1996