OOIR: Observatory of International Research

Papers

(The median citation count of Nucleosides Nucleotides & Nucleic Acids is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
The risk of relapse in breast cancer patients is associated with MMP-9 gene polymorphism: a prospective study in a sample of the Iranian population	25
Characterization of serum extracellular vesicles and their differential level of miR-197-3p in familial Mediterranean fever patients	21
MicroRNA-183-5p regulates MITF expression in vitiligo skin depigmentation	19
Structural, molecular hybridization and network based identification of miR-373-3p and miR-520e-3p as regulators of NR4A2 human gene involved in neurodegeneration	18
Synthesis and antiviral activity of 1,2,3-triazolyl nucleoside analogues with N-acetyl-d-glucosamine residue	13
Correction	12
Association of COL4A2 indel polymorphism with the development of stomach adenocarcinoma in Chinese populations	12
Toll-like receptor-2 (TLR-2) rs111200466 variant offers protection against SARS-CoV-2 infections and mortality: a worldwide epidemiological correlation analysis	12
Novel and PCR ready rapid DNA isolation from Drosophila	11
Study on the correlation between DPP9 rs2109069 and IFNAR2 rs2236757 polymorphisms with COVID-19 mortality	10
Precise control model of the epidemic: a cross-sectional study	10
Synthesis, spectroscopic and biological activity evaluation of Ni(II), Cu(II) and Zn(II) complexes of schiff base derived from pyridoxal and 4-fluorobenzohydrazide	10
Exhaled breath condensate efficacy to identify mutations in patients with lung cancer: A pilot study	9
Efficient chemical synthesis of N²-modified guanosine derivatives: a versatile probes for mRNA labeling	8
Synthesis of novel pyridine and pyrimidine thioglycoside phosphoramidates for the treatment of COVID-19 and influenza A viruses	8
Solvolysis of 2’-deoxyribonucleosides and oligo-2’-deoxyribonucleotides in aqueous pyrrolidine or ammonia solutions	8
Synthesis, characterization, and DNA binding study of ruthenium(II/III) complexes containing ONS donor Schiff base	8
Supplementary nucleosides improve the performance through enhanced enzyme activity, intestinal development and transporter genes in broiler chickens	7
The genetic variants of miR-1206 and miR-125b in breast cancer patients: in vitro and in silico analysis	7
The rs41291957 polymorphism of miR-143/145 and cancer risk: a case-control study and meta-analysis	7
Nano calcium zincate-assisted synthesis of benzo[ d ]thiazol-2-yl phenylisoxazoles: quantum computational, in silico molecular docking sim	7
Lower vitamin D levels and VDR variants are risk factors for breast cancer: an updated meta-analysis	7
Water-soluble nickel (II) Schiff base complexes: Synthesis, structural characterization, DNA binding affinity, DNA cleavage, cytotoxicity, and computational studies	6
Identification of autophagy and angiogenesis modulators in colorectal cancer based on bioinformatics analysis	6
Investigation of virulence factors in Pseudomonas aeruginosa isolates by phenotypic and genotypic methods	6

Interaction studies of water-soluble Zn(II) complex with calf thymus DNA using biophysical and molecular docking methods"	6
Identification of common genes and pathways underlying imatinib and nilotinib treatment in CML: a Bioinformatics Study	6
Novel synthesis of the first new class of triazine sulfonamide thioglycosides and the evaluation of their anti-tumor and anti-viral activities against human coronavirus	6
Effects of nucleoside analogues, lipophilic prodrugs and elaidic acids on core signaling pathways in cancer cells	6
Nucleic acids based integrated macromolecular complexes for SiRNA delivery: Recent advancements	6
Interplay of “leukemia inhibitory factor receptor gene” (rs3099124) polymorphism, leukemia inhibitory factor and ovarian steroids with unexplained infertility	5
Investigation of the possible effects of night shift on telomere length and mtDNA copy number in nurses	5
Molecular diversity of Klebsiella pneumoniae clinical isolates: antimicrobial resistance, virulence, and biofilm formation	5
Urinary 8-oxo-7,8-dihydroguanosine levels are elevated in HCV-infected patients	5
MicroRNA-138 inhibits hypoxia-inducible factor 1α expression in breast cancer cells	5
Genetic association study of CTLA4 and FCεRIα polymorphisms in asthmatic patients in the southwestern region of Iran	5
Differential expression analysis of CCDC107 and RMRP lncRNA as potential biomarkers in colorectal cancer diagnosis	5
Escherichia coli Orf135 (NudG) mutant protein specific for oxidized dATP	5
The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342	5
Optimum model selection and statistical analysis for DNA sequences	4
Fluorescent DNA analog: 2-aminotroponyl-pyrrolyl-2’-deoxyuridinyl DNA oligo enhance fluorescence in DNA-duplex as compared to 2-aminotroponyl-ethynyl-2’-deoxyuridinyl DNA oligo	4
Methylene-tetrahydrofolate reductase gene C677T and A1298C polymorphisms as a risk factor for Crimean-Congo hemorrhagic fever	4
Fabricate, advancement, molecular docking and DNA reactivity of preferred divalent metal(II) complexes attributing (E)-N’-((6-hydroxybenzo[d]oxazol-5-yl) methylene)isonicotinohydr	4
Synthesis of molnupiravir (MK-4482, EIDD-2801): a promising oral drug for the treatment of COVID-19 starting from cytidine	4
Genomic determinants in pathogenicity of SARS-CoV-2 versa common cold coronaviruses	4
Protective effect of FKBP12 on dextran sulfate sodium-induced ulcerative colitis in mice as a tacrolimus receptor	4
Purine analogs: synthesis, evaluation and molecular dynamics of pyrazolopyrimidines based benzothiazole as anticancer and antimicrobial CDK inhibitors	4
Association of TNFAIP8 gene polymorphisms with cancer risk in Chinese population	4
Association of rs11081062 polymorphism of DLGAP1 gene and levels of SLC1A1 protein with obsessive-compulsive disorder	4
In vitro galactose impairs energy metabolism in the brain of young rats: protective role of antioxidants	4
Design and synthesis of novel 1,3,4-thiadiazole thioglycosides as promising antimicrobial potent structures	4
Zebrafish as a model for study of disorders in pyrimidine nucleotide metabolism	4
Integrative bioinformatics analysis reveals ECM and nicotine-related genes in both LUAD and LUSC, but different lung fibrosis-related genes are involved in LUAD and LUSC	4
Lack of association between VNTR variant of the circadian gene (PER3) and major depressive disorder in a sample of a Turkish population	3
An evaluation method for uric acid uptake inhibition using primary human proximal tubule epithelial cells treated with insulin	3
Design and synthesis of fluorescence-labeled nucleotide with a cleavable aryl-triazene linker for DNA sequencing by synthesis	3
Proceedings of the 20 ^th International Symposium on Purine and Pyrimidine Metabolism in Man	3
ACPY2 gene polymorphisms on cancer risk: a systematic review and meta-analysis	3
DNA three-way junction structures with amino acid side chains prepared via post-synthetic amide condensation	3
Evaluating changes in the expression of BCL-2 gene, lncRNA SRA, and miR-361-3p in unexplained recurrent pregnancy loss	3
Molecular assessment of microbial diversity on eggshell of chukar partridges (Alectoris chukar) under semi-captive conditions	3
System biology analysis of miRNA-gene interaction network reveals novel drug targets in breast cancer	3
An update of the variant spectrum of the APC gene in Iranian familial adenomatous polyposis patients	3
Preparation of bicyclo[1.1.1]pentane-derived nucleoside analogues	3
Association between interferon-gamma ( IFN-γ ) gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-analysis	3
Angiotensin-converting enzyme I/D gene polymorphism and risk of type 2 diabetes mellitus in Iranian individuals	3
Investigation of MIF gene promoter variations and their haplotypes in the Alzheimer disease in Turkish population	3
Long noncoding RNA HOTAIR polymorphisms and susceptibility to bipolar disorder: a preliminary case–control study	3
TNF-α promoter variant (G-308A) is associated with susceptibility to P. falciparum infection and severe malaria: a meta-analysis and trial sequential analysis	3
Synthesis of new 1,2,3-triazolo-nucleoside analogues with 2-propargylamino pyrimidines via click reactions	3
Fabrication, depiction, DNA interaction, anti-bacterial, DFT and molecular docking studies of Co(II) and Cu(II) complexes of 3-methyl-1-phenyl-4-[(E)-(pyridin-2-yl)diazenyl]-1H-pyrazol-5	3
Bright fluorescent purine analogues as promising probes	3
Causal relationship between irritability and asthma: a bidirectional two-sample Mendelian randomization study	3
Treating gout – can hypouricemia produced by moderate doses of combined oral treatment give early treatment success? Preliminary observations	3
TERT silencing alters the expression of ARG1, GLUL, VIM, NES genes and hsa-miR-29b-3p in the T98G cell line	3

Association of fatty acid binding protein-4 (FABP-4) T87C and rs8192688 gene polymorphisms and FABP-4 level with cardiovascular disease susceptibility in type 2 diabetic patients	3
Demethylation of dimethyl phosphonate esters with sodium ethanethiolate: Improved synthesis of 5′-methylene substituted 2′,5′-deoxyribonucleotides	3
Molecular docking and spectroscopic study of bovine serum albumin interaction with new anticancer Pt complex with isopentyl dithiocarbamate ligand	3
New insights into complex formation by SARS-CoV-2 nsp10 and nsp14	3
Explore the molecular mechanism of angle-closure glaucoma in elderly patients induced telomere shortening of retinal ganglion cells through oxidative stress	3
Association of MBL2 gene polymorphisms with type 2 diabetes and its complications in Moroccan population	3
Comparison of different types of liposomal nano structures for microRNA transfection to human mesenchymal stem cell line S1939	3
The effect of VEGF and KDR gene variants on Crimean-Congo hemorrhagic fever	3
ATP2B1 genotypes rs2070759 and rs2681472 polymorphisms and risk of hypertension in Saudi population	3
Short-read next-generation sequencing of 16s rRNA gene amplicons for characterizing amplicon sequence variants (ASVs) and determination of gene copy numbers using ion Torrent platform	3
Impact of IL-6 and IL-6r variants on HIV-1 susceptibility and progression to AIDS: a case-control study in a Moroccan population	2
Identification of CSNK1D and KLK6 as two common upregulated genes present in BRCA1 mutated triple-negative breast cancer and ovarian epithelial carcinoma	2
Evaluation of N4-hydroxycytidine incorporation into nucleic acids of SARS-CoV-2-infected host cells by direct measurement with liquid chromatography-mass spectrometry	2
Association between Alzheimer’s disease, MAPT gene mutation and some biochemical biomarkers	2
MEG3 rs7158663 genetic polymorphism is associated with the risk of hepatocellular carcinoma	2
An artificial-restriction fragment length polymorphism (A-RFLP) method for genotyping intronic SNP rs7587633 C/T of ATG16L1	2
Novel mutation in alpha-spectrin gene in Saudi patients with hereditary spherocytosis	2
Organochlorine pesticide residues in agricultural draining water in Tunisia	2
Synthesis, structural, pharmacological and molecular docking simulations studies of Schiff base transition metal complexes procured from acetylacetonyl-4-iminoantipyrine and tyrosine	2
Current updates on genetic spectrum of usher syndrome	2
Anticancer sensitivity and biological aspect of 5-fluorouracil-resistant human colorectal cancer HCT116 cells in three-dimensional culture under high- and low-glucose conditions	2
Association between CDKN1A gene rs1801270 polymorphisms and susceptibility to colorectal cancser in an Iranian population	2
Do not sacrifice the snail—conservative DNA extraction for terrestrial gastropods based on periostracum fraction and pedal mucus	2
Differential expression of KCNQ1 and ATP4A genes according to the sex and age in the stomach	2
Silver(I)-mediated base pairing involving an S-glycosidic GNA nucleoside analogue	2
DNA nanotechnology for cell-free DNA marker for tumor detection: a comprehensive overview	2
Bioinformatics analysis of key genes and potential therapeutic agents for vascular calcification in chronic kidney disease	2
Algal organic matter induced photodegradation of tinidazole	2
Evaluation of possible role of the hTERT gene rs2853669 polymorphism in the development of colorectal cancer as a genetic risk factor	2
High throughput screening of a new fluorescent G-quadruplex ligand having telomerase inhibitory activity in human A549 cells	2
Evaluation of the 18-bp deletion/insertion variant of the VEGF gene in athletes	2
Synthesis of 2′-deoxyguanosine from 2′-deoxyadenosine via C2 nitration	2
Involvement of NRON and TUG1 long noncoding RNAs in inflammation and the pathogenesis of EAE	2
The effect of Paraoxonase gene polymorphisms and paraoxonase enzyme activity on Non-Hodgkin lymphoma	2
Vitamin D receptor (VDR) variants are risk factors for ovarian cancer: a meta-analysis and trial sequential analysis	2
Interaction of the platinum complex of tyrosine-β-cyclodextrin with G-quadruplex DNA	2
Correlation of growth differentiation factor-5 + 104T>C polymorphism with the risk of knee, hand, and hip osteoarthritis: a case-control study and meta-analysis based on 47 case-control studies	2
LncRNA PGM5-AS1 inhibits the progression of breast cancer by inhibiting miR-182-5p	2
Construction of a novel mRNA–miRNA–lncRNA/circRNA triple subnetwork associated with immunity and aging in intervertebral disc degeneration	2
Association between polymorphism at codon 469 of the ICAM-1 gene and Henoch-Schönlein purpura in an Iranian cohort	2
In vitro selection of a single-strand DNA aptamer targeting the receptor-binding domain of SARS-CoV-2 spike protein	2
Harmine promotes odontoblastic differentiation of dental pulp stem cells	2
Association between the IL-1A, IL-1B and IL-1R polymorphisms and lymphoma	2
A general and efficient approach to synthesize the phosphoramidites of 5′-¹⁸O labeled purine nucleosides	2
Synthesis, characterization, and biological applications of pyrazole moiety bearing osmium(IV) complexes	2
p-Toluenesulfonic acid adorned on MCM-41: an efficient and mild catalyst for the regio/chemo-selective hydrolysis of terminal isopropylidene acetals	2
Light-regulated RNA interference induced by p-hydroxyphenacyl-modified siRNA in mammalian cells	2
New insights in research on purine and pyrimidine metabolism	2
PSAT1gene as a biomarker for targeting triple negative breast cancer in presence of Rapamycin	2
Association between PAX8AS1 (rs4848320 C > T, rs1110839 G > T, and rs6726151 T > G) and MEG3 (rs7158663) gene polymorphisms and non-Hodgkin lymphoma risk	2
Genetic insights into bladder cancer: the impact of SIRT1 gene polymorphism	1
Expression of lncRNAs AK058003 and APOC1P1 in breast cancer patients	1
Human CD4⁺CD25⁺CD127^lowFOXP3⁺ regulatory T lymphocytes and CD4⁺CD25^-FOXP3^- conventional T lymphocytes: a differential trans	1
Promoter methylation status of RASSF1A and RASSF2A tumor suppressor genes in endometrial endometrioid carcinomas	1
An improved protection-free one-pot chemical synthesis of purine locked nucleic acid nucleoside-5′-triphosphates	1
Convenient syntheses of isotopically labeled pyrimidine 2’-deoxynucleosides and their 5-hydroxy oxidation products	1
In silico strategies for modeling RNA aptamers and predicting binding sites of their molecular targets	1
The effect of a 18 bp deletion/insertion variant of VEGF gene on the FMF development	1
Pharmacological mechanisms underlying the interaction of the nucleoside analogue gemcitabine with the c-MET inhibitor tivantinib in pancreatic cancer	1
Glucose-PEG2000-DSPE modified carbamazepine nano system alleviated cell apoptosis and oxidative stress in epilepsy	1
Variability in CD39 and CD73 protein levels in uveal melanoma patients	1
Biocatalyst-mediated selective acylation and deacylation chemistry on the secondary hydroxyl/amine groups of nucleosides	1
Role of VEGF I/D variant in suspectibility to odontogenic cyst formation	1
Investigation of the relationship between ACAN gene VNTR polymorphism and Alzheimer’s disease in Turkish population	1
Effect of IL-6 -174G/C and -572G/C variants on susceptibility to osteoarthritis in Turkish population	1
Interrelationships among MTHFR gene polymorphisms, MTRR gene polymorphisms, and HBV gene BCP 1762/1764 mutations with disease progression in Chronic hepatitis B virus infection patients	1
Design, synthesis and chemical stability of indolizine derivatives for antidiabetic activity	1
Unusual effects of PCSK9 E670G (rs505151) variation in patients with in-stent restenosis: Variable effects on restenosis risk according to concomitant chronic conditions	1
Desalting of oligonucleotides through precipitation for mass spectrometric analysis	1
Identification of lung adenocarcinoma subtypes based on mitochondrial energy metabolism-related genes	1
Bioinformatics and meta-analysis of the clinical significance of RECK expression and its genetic polymorphisms in cancer	1
Human microRNA hsa-miR-15b-5p targets the RNA template component of the RNA-dependent RNA polymerase structure in severe acute respiratory syndrome coronavirus 2	1
Tuberculosis and lung cancer: metabolic pathways play a key role	1
Nucleotide metabolism during experimental preservation for transplantation with Transmedium Transplant Fluid (TTF) in comparison to Histidine-Tryptophan-Ketoglutarate (HTK)	1
Synthesis, antimicrobial, SAR, PASS, molecular docking, molecular dynamics and pharmacokinetics studies of 5′-O-uridine derivatives bearing acyl moieties: POM study and identification of the ph	1
Bioinformatics analysis of differentially expressed genes in hyperplastic scars using microarray data	1
Transcriptome-based identification of molecular markers related to the development and prognosis of Colon cancer	1
Glucose depletion reduces cholesterol intracellular accumulation in ABCB1-dependent mechanism	1
Free-fatty acid receptor-4 gene polymorphism (rs61866610) and colorectal cancer risk	1
Clinical diagnostic value and potential regulatory mechanisms of lncRNA NOP14-AS1 in chronic kidney disease	1

Correction	1
Proceedings of the 19^th International Symposium on purine and pyrimidine metabolism in man	1
IL2RA rs2104286 and IL2 rs2069762 polymorphisms may be associated with bipolar disorder and its clinical findings	1
Association between HULC rs7763881 and cancer risk: an updated Meta-analysis	1
Different expression of DACT1 , DACT2, and CYCLIN D1 genes in human colorectal cancer tissues and its assoc	1
RREB1 promotes the development of parafollicular carcinogenesis through the Ras-Raf-1-ELK3 signaling pathway	1
Theoretical and experimental investigation of mixed-ligand metal(II) Schiff base complexes using maleic acid as the auxiliary ligand	1
Synthesis, anticancer activity and molecular docking of new triazolo[4,5-d]pyrimidines based thienopyrimidine system and their derived N-glycosides and thioglycosides	1
Association between CTLA4 + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis	1
Evaluating interleukin-6 levels and the rs1800795 variant in Turkish patients with COVID-19: a prospective cohort study	1
Association of eNOS gene 4a/4b VNTR and T786C polymorphism with Crimean-Congo hemorrhagic fever	1
A gene expression analysis of long non-coding RNAs NKILA and PACER as well as their target genes, NF-κB and cox-2 in bipolar disorder patients	1
Unusual seven-membered ring sugars and nucleosides: synthesis and biological properties	1
Synthesis, structural elucidation, DNA binding, cleavage, AChE and BuChE cholinesterase efficiencies of metal complexes with 1,10-phenanthroline scaffold	1
Evaluation of the association COMT Val158Met variant and childhood trauma on aggression in Turkish SCZ patients	1
Urate levels and clearance in renal patients under peritoneal dialysis	1
The decreased serum activity of cytosolic 5′-nucleotidase IA as a potential marker of breast cancer-associated muscle inflammation	1
MiRNA-miRNA interaction network in peripheral blood of patients with myocardial infarction: a gene expression meta-analysis	1
The emerging roles of glutamine amidotransferases in metabolism and immune defense	1
Clinical significance of LIN28A gene polymorphisms and expression in pan-cancer: a meta-analysis and bioinformatic analysis	1
In memory of an exquisite medicinal chemist, Prof. Morris Robins	1
DNA damage-inducing endogenous and exogenous factors and research progress	1
Synthesis, characterization and molecular docking studies of new indol(1H-3-yl)pyrimidine derivatives: Insights into their role in DNA interaction	1
Clinical significance of RETN gene expression and rs3219175 G > a polymorphism in cancer	1
The comparison of nucleotide metabolites and amino acids patterns in patients with eating disorders, with and without symptoms of depression	1
The investigation of host genetic variants of toll-like receptor 7 and 8 in COVID-19	1
Investigation of bisindole-linked pyrimidine moieties: synthesis using strantium–aluminum supported strontium aluminate nanophosphors catalyst, DNA reactivity, and in silico	1
HMGA2 rs968697 T > C polymorphism is associated with the risk of colorectal cancer	1
Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in Turkish postmenopausal women with osteoporosis	1
IL-18 and CD14 variants in chronic HBV predisposition: a case-control study with in silico analyses focused on transcri	1
The evaluation of the SMAD1 rs1016792 polymorphism and gene expression on pulmonary hypertension due to congenital heart disease in children: a preliminary study	1
Clinicopathological and prognostic value of CD44 gene polymorphism (rs187115) in Swedish patients with colorectal cancer	1
6-azido and 6-azidomethyl uracil nucleosides	1
In silico and POM analysis for potential antimicrobial agents of thymidine analogs by using molecular docking, molecular dynamics and ADMET profiling	1
Development of low-cost in-house tetra-ARMS-PCR assay for the screening of five CBS mutations found in Pakistani homocystinuria patients	1
Prognostic significance of copper metabolism-related genes as risk markers in bladder urothelial carcinoma	1
The association of IGF1 rs35767 polymorphism with colorectal cancer risk in the Chinese Han population	1
Association between ACE (rs4343 and rs1799752), AGTR1 (rs5186), and PAI-1 (rs2227631) polymorphisms in the	1
Polymorphisms of miR-146a and susceptibility to ulcerative colitis risk: a case-control study	1
An expanded framework toward improving the detritylation reaction in solid-phase oligonucleotide syntheses – filling the gap	1
Synthesis and in vitro biochemical properties, DNA binding and DNA cleavage ability of copper complexes of hydroxyflavone derivatives of novel organosulfur compounds as therapeutic agent	1
Evaluation of miR-130b-3p and miR-375 levels and telomere length with telomerase activity in prostate cancer	1
Deprotection of N1-methyladenosine-containing RNA using triethylamine hydrogen fluoride	1
Synthesis and applications of bicyclic sugar modified locked nucleic acids: A review	1
50-bp insertion/deletion polymorphism of the superoxide dismutase-1 is associated with bladder cancer risk in an Iranian population	1
Histone chaperones as potential epidrug targets against cancer	1
Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase	1
Integrated bioinformatics analysis of ferroptosis-related gene signature in inflammation and immunity in intervertebral disc degeneration	1
Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population	1
Nucleotide depletion in hypoxia experimental models of mouse myocardial slices	1
Vascular endothelial growth factor I/D variant and postmenopausal osteoporosis risk in the Turkish population	1
Advancement in specific strand scission of DNA and evaluation of in-vitro biological assessment by pharmacologically significant tetraaza macrocyclic metal complexes constrained by triazole	1