OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Therapy is 61. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Current Clinical Applications of In Vivo Gene Therapy with AAVs	382
Plant Exosome-like Nanovesicles: Emerging Therapeutics and Drug Delivery Nanoplatforms	212
CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?	193
A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice	189
Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug	176
A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties	151
AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9	142
xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling	141
A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis	135
M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2	133
Emerging mechanisms and targeted therapy of ferroptosis in cancer	130
Treatment of a Mouse Model of ALS by In Vivo Base Editing	129
Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities	126
Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B	125
CRISPR-Cas9: A Preclinical and Clinical Perspective for the Treatment of Human Diseases	124
METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression	118
lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/β-Catenin Pathway and Oncogenic Autophagy	110
A comprehensive analysis of the efficacy and safety of COVID-19 vaccines	104
COVID-19 mRNA vaccines: Platforms and current developments	102
Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12	102
A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice	100
Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine	100
A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19	100
Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes	99
Gene therapy for ALS: A review	94

Engineered Circular RNA Sponges Act as miRNA Inhibitors to Attenuate Pressure Overload-Induced Cardiac Hypertrophy	93
Tumor-derived exosomal microRNA-106b-5p activates EMT-cancer cell and M2-subtype TAM interaction to facilitate CRC metastasis	92
AAV vectors: The Rubik’s cube of human gene therapy	91
Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs	90
Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines	90
In vivo somatic cell base editing and prime editing	89
Clinical Perspective: Treating RPE65-Associated Retinal Dystrophy	89
Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors	89
METTL3 Promotes Tumorigenesis and Metastasis through BMI1 m6A Methylation in Oral Squamous Cell Carcinoma	89
Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice	86
Exosomal miR-208b related with oxaliplatin resistance promotes Treg expansion in colorectal cancer	84
Dual-AAV delivering split prime editor system for in vivo genome editing	81
In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes	81
CART19-BE-01: A Multicenter Trial of ARI-0001 Cell Therapy in Patients with CD19+ Relapsed/Refractory Malignancies	79
A Phase 2/3 Trial of Pabinafusp Alfa, IDS Fused with Anti-Human Transferrin Receptor Antibody, Targeting Neurodegeneration in MPS-II	79
Role of METTL3-Dependent N6-Methyladenosine mRNA Modification in the Promotion of Angiogenesis	75
Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment	74
METTL3 restrains papillary thyroid cancer progression via m6A/c-Rel/IL-8-mediated neutrophil infiltration	73
Synergistic and Antagonistic Drug Combinations against SARS-CoV-2	73
Evaluating the state of the science for adeno-associated virus integration: An integrated perspective	72
Current Status and Challenges of DNA Base Editing Tools	72
Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels	72
Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations	72
m6A RNA Methylation in Cardiovascular Diseases	71
Comprehensive Molecular Profiles of Functionally Effective MSC-Derived Extracellular Vesicles in Immunomodulation	70
lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling	68
HucMSC-Derived Exosomes Mitigate the Age-Related Retardation of Fertility in Female Mice	68
circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway	68
Circular RNAs: Expression, localization, and therapeutic potentials	66
Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression	66
A Molecular Revolution in the Treatment of Hemophilia	65
AAV integration in human hepatocytes	65
Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis	65
The evolving landscape of N6-methyladenosine modification in the tumor microenvironment	63
Liver Injury Increases the Incidence of HCC following AAV Gene Therapy in Mice	62
Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments	61
Development of CAR T Cells Expressing a Suicide Gene Plus a Chimeric Antigen Receptor Targeting Signaling Lymphocytic-Activation Molecule F7	61