OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Therapy is 63. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Current Clinical Applications of In Vivo Gene Therapy with AAVs	454
Plant Exosome-like Nanovesicles: Emerging Therapeutics and Drug Delivery Nanoplatforms	281
CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?	225
A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties	180
xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling	179
Emerging mechanisms and targeted therapy of ferroptosis in cancer	168
M2 Macrophage-Derived Exosomes Promote Angiogenesis and Growth of Pancreatic Ductal Adenocarcinoma by Targeting E2F2	167
A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis	163
CRISPR-Cas9: A Preclinical and Clinical Perspective for the Treatment of Human Diseases	158
Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities	150
METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression	139
COVID-19 mRNA vaccines: Platforms and current developments	133
AAV vectors: The Rubik’s cube of human gene therapy	133
Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12	129
Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine	126
lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/β-Catenin Pathway and Oncogenic Autophagy	126
Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs	122
Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment	119
A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice	114
A comprehensive analysis of the efficacy and safety of COVID-19 vaccines	114
Tumor-derived exosomal microRNA-106b-5p activates EMT-cancer cell and M2-subtype TAM interaction to facilitate CRC metastasis	112
A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19	110
Gene therapy for ALS: A review	108
Macrophages as a therapeutic target to promote diabetic wound healing	108
Clinical Perspective: Treating RPE65-Associated Retinal Dystrophy	106

In vivo somatic cell base editing and prime editing	106
Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines	100
Evaluating the state of the science for adeno-associated virus integration: An integrated perspective	97
Dual-AAV delivering split prime editor system for in vivo genome editing	95
Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression	95
CART19-BE-01: A Multicenter Trial of ARI-0001 Cell Therapy in Patients with CD19+ Relapsed/Refractory Malignancies	95
Exosomal miR-208b related with oxaliplatin resistance promotes Treg expansion in colorectal cancer	94
lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling	94
METTL3 restrains papillary thyroid cancer progression via m6A/c-Rel/IL-8-mediated neutrophil infiltration	93
A Phase 2/3 Trial of Pabinafusp Alfa, IDS Fused with Anti-Human Transferrin Receptor Antibody, Targeting Neurodegeneration in MPS-II	93
circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway	88
CXCL11-armed oncolytic adenoviruses enhance CAR-T cell therapeutic efficacy and reprogram tumor microenvironment in glioblastoma	86
Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma	86
Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations	85
Circular RNAs: Expression, localization, and therapeutic potentials	84
Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels	83
Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments	83
Synergistic and Antagonistic Drug Combinations against SARS-CoV-2	80
Long-term efficacy and safety of eladocagene exuparvovec in patients with AADC deficiency	78
METTL3-mediated m6A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy	78
AAV integration in human hepatocytes	76
Liver Injury Increases the Incidence of HCC following AAV Gene Therapy in Mice	73
The evolving landscape of N6-methyladenosine modification in the tumor microenvironment	72
Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading	71
Photodynamic therapy synergizes with PD-L1 checkpoint blockade for immunotherapy of CRC by multifunctional nanoparticles	70
Aptamers: Cutting edge of cancer therapies	69
Development of CAR T Cells Expressing a Suicide Gene Plus a Chimeric Antigen Receptor Targeting Signaling Lymphocytic-Activation Molecule F7	69
Extracellular vesicles: The next generation in gene therapy delivery	68
Exosomal miR-1246 from glioma patient body fluids drives the differentiation and activation of myeloid-derived suppressor cells	68
circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular carcinoma	67
Emerging Role of Ubiquitination in the Regulation of PD-1/PD-L1 in Cancer Immunotherapy	67
Olaparib Suppresses MDSC Recruitment via SDF1α/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice	66
PRMT5 regulates RNA m6A demethylation for doxorubicin sensitivity in breast cancer	66
YAP Circular RNA, circYap, Attenuates Cardiac Fibrosis via Binding with Tropomyosin-4 and Gamma-Actin Decreasing Actin Polymerization	66
A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq	66
Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics	66
Ginseng-derived nanoparticles potentiate immune checkpoint antibody efficacy by reprogramming the cold tumor microenvironment	65
Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in human breast cancers	64
Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m6A-Based Epitranscriptomic Mechanism	63
Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion	63
Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis	63