OOIR: Observatory of International Research

Papers

(The TQCC of Antioxidants & Redox Signaling is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis	139
Impact of Mitochondrial Architecture, Function, Redox Homeostasis, and Quality Control on Organismic Aging: Lessons from a Fungal Model System	118
Disturbance of Fetal Growth by Azithromycin Through Induction of ER Stress in the Placenta	109
Does NLRP1 Inflammasome Activation in Immune Cells in Kidney Transplantation Relate with Donor Organ Age?	103
The KEAP1-NRF2 system and neurodegenerative diseases	99
Mitochondrial Mechanisms in Immunity and Inflammatory Conditions: Beyond Energy Management	97
Oxidative Stress, Transfer RNA Metabolism, and Protein Synthesis	92
The redox protein HMGB1 in cell death and cancer	91
Blood–Labyrinth Barrier in Health and Diseases: Effect of Hormetic Nutrients	87
Cystathionine γ-Lyase Attenuates Vascular Smooth Muscle Cell Senescence via Foxm1-Gas1 Pathway to Mediate Arterial Stiffness	76
MicroRNA-Mediated Mitochondrial Dysfunction Is Involved in the Anti-triple-Negative Breast Cancer Cell Activity of Phytosesquiterpene Lactones	71
The Antioxidant Ergothioneine Alleviates Cisplatin-Induced Hearing Loss Through the Nrf2 Pathway	68
Modes of Mitochondrial Reactive Oxygen Species Production in Inflammation	58
Regulation of Erythroid Differentiation via the HIF1α-NFIL3-PIM1 Signaling Axis Under Hypoxia	55
PGK1 Persulfidation Promotes the Proliferation and Metastasis of Breast Cancer	51
Deletion of GPX8 Enhances Irradiation-Induced Ferroptosis Through m ⁶ A Hypomethylation-Mediated Upregulation of ACSL4 in Oral Cancer	49
Modulation of Innate Immune Memory Dynamics by Subcellular Reactive Oxygen Species	49
Nogo-B Promotes Endoplasmic Reticulum Stress-Mediated Autophagy in Endothelial Cells of Diabetic Nephropathy	49
Pathological Impact of Redox Post-Translational Modifications	47
Ferroptosis As Ultimate Target of Cancer Therapy	46
Mitochondrial NAD ⁺ Transport Alleviates Cerebral Ischemia/Reperfusion Injury via Enhancement of Mitochondrial Function	46
Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma	46
Oxidative Stress and Pyroptosis Mediated by CEBPB/HMGB1 Signaling in Sepsis-Exacerbated Coronary Atherosclerosis	45
Redox Signaling and Stress in Inherited Myopathies	44
Exosomal Prolactin-Induced Protein Inhibits the Activation of cGMP/PKG Pathway Mediated by ATP2B2 to Promote Myocardial Fibrosis in Atrial Fibrillation	44

Cytokine–Microglia Interactions in Neuroinflammation: Mechanisms, Disease Dynamics, and Therapeutic Strategies	44
Reactive Oxygen Species and Their Consequences on the Structure and Function of Mammalian Spermatozoa	42
Emerging Chemical Biology of Protein Persulfidation	41
Retinoic Acid Receptor-related Orphan Receptor α Drives Glucose Reprogramming and Mitochondrial Rescue Mitigate Subarachnoid Hemorrhage-Induced Early Brain Injury	41
The Emergence of Tumor-Initiating Cells in an Advanced Hypopharyngeal Tumor Model Exhibits Enhanced Angiogenesis and Nuclear Factor Erythroid 2-Related Factor 2-Associated Antioxidant Effects	40
Inflammation Impairs Poststroke Recovery by Disrupting Iron Homeostasis in Brain	40
TXNIP Exacerbates the Senescence and Aging-Related Dysfunction of β Cells by Inducing Cell Cycle Arrest Through p38-p16/p21-CDK-Rb Pathway	40
Preferential Secretion of Oxidation-Sensitive Proteins by Unconventional Pathways: Why is This Important for Inflammation?	40
Urinary Matrix Metalloproteinase 7 Activated by Oxidative Stress Predicts Kidney Prognosis in Myeloperoxidase–Antineutrophil Cytoplasmic Antibody-Associated Vasculitis	40
Alpha-Tocopherol from People to Plants Is an Essential Cog in the Metabolic Machinery	39
Selenocompounds and Sepsis—Redox Bypass Hypothesis: Part B-Selenocompounds in the Management of Early Sepsis	39
Does SLC39A8 Ala391Thr Confer Risk of Chronic Liver Disease?	39
Potential of Cytochrome P450, a Family of Xenobiotic Metabolizing Enzymes, in Cancer Therapy	38
SMAD4 Inhibits HO-1–Driven Ferroptosis Through Transcriptional Repression in Sepsis-Associated Acute Kidney Injury	38
Pathomechanistic Synergy Between Particulate Matter and Traffic Noise-Induced Cardiovascular Damage and the Classical Risk Factor Hypertension	38
Comparison of the Nitric Oxide Synthase Interactomes and S-Nitroso-Proteomes: Furthering the Case for Enzymatic S-Nitrosylation	37
Beneficial Effects of Corylin on Metabolic Dysfunction-Associated Fatty Liver Disease	37
L -Ergothioneine Attenuates Nephrolithiasis by Modulating Redox Signaling and Mitochondrial Function in Cystine and Calcium Oxalate Models	36
Systemic Mutation of Ncf1 Ameliorates Obstruction-Induced Renal Fibrosis While Macrophage-Rescued NCF1 Further Alleviates Renal Fibrosis	35
What Is the Redox Potential of Ergothioneine?	35
Mechanistic Insights into Alternative Gene Splicing in Oxidative Stress and Tissue Injury	34
4-Hydroxynonenal Promotes Colorectal Cancer Progression Through Regulating Cancer Stem Cell Fate	34
Sirtuins: The NAD ⁺ -Dependent Multifaceted Modulators of Inflammation	33
Calcium Homeostasis in the Control of Mitophagy	33
Evidence for Constitutive Microbiota-Dependent Short-Term Control of Food Intake in Mice: Is There a Link with Inflammation, Oxidative Stress, Endotoxemia, and GLP-1?	33
Hypoxia-Induced Changes in Endothelial Cell Phenotype and Function	33
Oxygen Sensing in Innate Immune Cells: How Inflammation Broadens Classical Hypoxia-Inducible Factor Regulation in Myeloid Cells	32
Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome	32
Modulation of NRF2: Biological Dualism in Cancer, Targets and Possible Therapeutic Applications	32
Hydrogen Sulfide in Diabetic Complications Revisited: The State of the Art, Challenges, and Future Directions	32
Environmental Chemical-Induced Reactive Oxygen Species Generation and Immunotoxicity: A Comprehensive Review	32
Reflections of an Aging Free Radical Part 2: Meeting Inspirational People	31
Gasotransmitter-Mediated Cysteinome Oxidative Posttranslational Modifications: Formation, Biological Effects, and Detection	31
ARS Forum Oxygen Sensing	31
Nicotinamide Adenine Dinucleotide Precursor Supplementation Modulates Neurite Complexity and Survival in Motor Neurons from Amyotrophic Lateral Sclerosis Models	31
Cardiovascular Effects of Environmental Metal Antimony: Redox Dyshomeostasis as the Key Pathogenic Driver	30
α-Ketoglutarate Attenuates Hyperlipidemia-Induced Endothelial Damage by Activating the Erk-Nrf2 Signaling Pathway to Inhibit Oxidative Stress and Mitochondrial Dysfunction	30
Increased Neuronal Nitric Oxide Synthase in Alzheimer's Disease Mediates Spontaneous Calcium Signaling and Divergent Glutamatergic Calcium Responses	30
High Incidence of Lethal Ventricular Arrhythmia-Sudden Cardiac Death in Early Myocardial Ischemia: Critical Roles of Cross-Regulation Between Stresses and Calcium Imbalance	30
PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARα Activation in Rats Fed High-Fat Diet	30
NINJ1 Aggravates Doxorubicin-Induced Cardiotoxicity by Suppressing AMPK-Mediated HIF-1α Deubiquitination	30
Correction to: Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages by Miao, et al.	29
Impacts of Radiation on Metabolism and Vascular Cell Senescence	29
ALOX15 Modulates Ferroptosis via the Reactive Oxygen Species-Mediated MAPK Pathway in Doxorubicin-Induced Cardiotoxicity	29
Thiol-Based Modification of MarR Protein VnrR Regulates Resistance Toward Nitrofuran in Vibrio cholerae By Promoting the Expression of a Novel Nitroreduc	29
NADPH Oxidases in Neurodegenerative Disorders: Mechanisms and Therapeutic Opportunities	29
Corrigendum to: “Angiotensin-Converting Enzyme-Dependent Intrarenal Angiotensin II Contributes to CTP: Phosphoethanolamine Cytidylyltransferase Downregulation, Mitochondrial	28
Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for Antioxidants & Redox Signaling	28
Oxygen Sensing in Neurodegenerative Diseases: Current Mechanisms, Implication of Transcriptional Response, and Pharmacological Modulation	28
Ferroptosis in Tubular Epithelial Cells Across Distinct Renal Regions Is a Primary Causal Factor for Lupus Nephritis	28

Correction to: H ₂ S-Generating Cytosolic L-Cysteine Desulfhydrase and Mitochondrial D-Cysteine Desulfhydrase from Sweet P	28
Radiation-Induced Bystander Effect on the Genome of Bone Marrow Mesenchymal Stem Cells in Lung Cancer	27
A Novel Synthesized Cyclohexane-Hydroxytyrosol Derivative Suppresses Ovarian Cancer Cell Growth Through Inducing Reactive Oxidative Species and Blocking Autophagic Flux	27
Hydrogen Sulfide Regulates Macrophage Function in Cardiovascular Diseases	26
Cellular Stress Response (Hormesis) in Response to Bioactive Nutraceuticals with Relevance to Alzheimer Disease	25
Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage	25
Adaptive and Pathological Outcomes of Radiation Stress-Induced Redox Signaling	25
Adaptive Responses to Hypoxia and/or Hyperoxia in Humans	24
Thrombosis and Aging: Fibrin Clot Properties and Oxidative Stress	24
Sirtuin 5 Alleviates Liver Ischemia/Reperfusion Injury by Regulating Mitochondrial Succinylation and Oxidative Stress	24
Epigenetic Control of Redox Pathways in Cancer Progression	24
Mitochondrial Redox Signaling in O ₂ -Sensing Chemoreceptor Cells	24
The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling	23
Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health by Drosophila Model	23
Physiological and Pathophysiological Roles of Thioredoxin Interacting Protein: A Perspective on Redox Inflammation and Metabolism	22
Nitrated Nuclear Receptor Coactivator 4 Contributes to Ferritinophagy in Hyperhomocysteinemia-Induced Liver Injury	22
Reactive Oxygen Species/Reactive Nitrogen Species as Messengers in the Gut: Impact on Physiology and Metabolic Disorders	22
Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia	22
Reactive Sulfur Species in Human Diseases	21
Insights Into Antioxidant Strategies to Counteract Radiation-Induced Male Infertility	21
Sestrin 2 Deficiency Exacerbates Noise-Induced Cochlear Injury Through Inhibiting ULK1/Parkin-Mediated Mitophagy	21
Hydrogen Sulfide and Functional Therapy: Novel Mechanisms from Epigenetics	21
High Uric Acid Orchestrates Ferroptosis to Promote Cardiomyopathy Via ROS-GPX4 Signaling	21
Advances in the Functions of Thioredoxin System in Central Nervous System Diseases	21
Platelet Mitochondria: A Promising Target for Antiplatelet Therapy	20
Exploring the Molecular Interplay Between Oxygen Transport, Cellular Oxygen Sensing, and Mitochondrial Respiration	20
Role of Excessive Mitochondrial Fission in Seawater Immersion Aggravated Hemorrhagic Shock–Induced Cardiac Dysfunction and the Protective Effect of Mitochondrial Division Inhibitor-1	20
Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype	20
Sulfur Dioxide Alleviates Aortic Dissection Through Inhibiting Vascular Smooth Muscle Cell Phenotype Switch, Migration, and Proliferation via miR-184-3p/	19
Hemoglobin Oxidation and Heme in Atherosclerosis—Link Between Intraplaque Hemorrhage and Progression of Complicated Atherosclerotic Lesion	19
Alterations in Mitochondrial Function in Pulmonary Vascular Diseases	19
Modulation of Protein Disulfide Isomerase Functions by Localization: The Example of the Anterior Gradient Family	19
RNA and RNA Derivatives: Light and Dark Sides in Cancer Immunotherapy	19
Pleiotropic Regulation of PGC-1α in Tumor Initiation and Progression	19
KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation Disease	19
GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Attenuates Skeletal Muscle Abnormalities in a Murine Model of Duchenne Muscular Dystrophy	19
Succinate Activates Uncoupling Protein 2 to Suppress Neuroinflammation and Confer Protection Following Intracerebral Hemorrhage	19
Non-thermal Plasma-Derived Reactive Oxygen Species Induces Cell Death in Radioresistant Head and Neck Cancer via the c-MET/STAT3 Pathway	18
CircGNAQ Promotes Intracranial Aneurysm Formation by Facilitating Vascular Smooth Muscle Cell Phenotypic Switching and Apoptosis	18
Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes	18
Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills	18
Histone demethylase KDM5D represses the proliferation, migration and invasion of hepatocellular carcinoma through the E2F1/TNNC1 axis	18
Aging and Antithrombotic Treatment	18
ACE2 Activation in Intestinal Epithelial Cells Prevents Radiation-Induced Intestinal Injury	18
Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response	18
Sodium in Mitochondrial Redox Signaling	18
Targeting the HNRNPA2B1/HDGF/PTN Axis to Overcome Radioresistance in Non-Small Cell Lung Cancer	17
Remote Organ Damage Induced by Stroke: Molecular Mechanisms and Comprehensive Interventions	17
H ₂ S: A Simple Molecule with Multifaceted Biochemistry and Functions	17
RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα	17
NAD ⁺ , Axonal Maintenance, and Neurological Disease	17
Mitochondrial Dynamics and Cristae Shape Changes During Metabolic Reprogramming	17
Mitochondria-Targeted Compounds to Assess and Improve Human Sperm Function	17