OOIR: Observatory of International Research

Papers

(The TQCC of Antioxidants & Redox Signaling is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Modes of Mitochondrial Reactive Oxygen Species Production in Inflammation	152
The KEAP1-NRF2 system and neurodegenerative diseases	132
The Antioxidant Ergothioneine Alleviates Cisplatin-Induced Hearing Loss Through the Nrf2 Pathway	111
Mild Therapeutic Hypothermia and Putative Mechanisms of Hair Cell Survival in the Cochlea	105
MicroRNA-Mediated Mitochondrial Dysfunction Is Involved in the Anti-triple-Negative Breast Cancer Cell Activity of Phytosesquiterpene Lactones	103
Mitochondrial Mechanisms in Immunity and Inflammatory Conditions: Beyond Energy Management	97
Oxidative Stress, Transfer RNA Metabolism, and Protein Synthesis	94
Impact of Mitochondrial Architecture, Function, Redox Homeostasis, and Quality Control on Organismic Aging: Lessons from a Fungal Model System	88
Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis	84
Blood–Labyrinth Barrier in Health and Diseases: Effect of Hormetic Nutrients	83
Disturbance of Fetal Growth by Azithromycin Through Induction of ER Stress in the Placenta	80
Does NLRP1 Inflammasome Activation in Immune Cells in Kidney Transplantation Relate with Donor Organ Age?	75
Cystathionine γ-Lyase Attenuates Vascular Smooth Muscle Cell Senescence via Foxm1-Gas1 Pathway to Mediate Arterial Stiffness	75
The redox protein HMGB1 in cell death and cancer	67
Contribution of Mitochondria to Insulin Secretion by Various Secretagogues	66
Altered Metabolism in Alzheimer Disease Brain: Role of Oxidative Stress	65
Exosomal Prolactin-Induced Protein Inhibits the Activation of cGMP/PKG Pathway Mediated by ATP2B2 to Promote Myocardial Fibrosis in Atrial Fibrillation	60
The Role of Perivascular Adipose Tissue-Derived Hydrogen Sulfide in the Control of Vascular Homeostasis	60
Nogo-B Promotes Endoplasmic Reticulum Stress-Mediated Autophagy in Endothelial Cells of Diabetic Nephropathy	57
Pathological Impact of Redox Post-Translational Modifications	50
PGK1 Persulfidation Promotes the Proliferation and Metastasis of Breast Cancer	49
Oxidative Stress and Pyroptosis Mediated by CEBPB/HMGB1 Signaling in Sepsis-Exacerbated Coronary Atherosclerosis	49
Retinoic Acid Receptor-related Orphan Receptor α Drives Glucose Reprogramming and Mitochondrial Rescue Mitigate Subarachnoid Hemorrhage-Induced Early Brain Injury	45
Cytokine–Microglia Interactions in Neuroinflammation: Mechanisms, Disease Dynamics, and Therapeutic Strategies	44
Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma	43

Redox Signaling and Stress in Inherited Myopathies	42
Modulation of Innate Immune Memory Dynamics by Subcellular Reactive Oxygen Species	42
Reactive Oxygen Species and Their Consequences on the Structure and Function of Mammalian Spermatozoa	41
Regulation of Erythroid Differentiation via the HIF1α-NFIL3-PIM1 Signaling Axis Under Hypoxia	41
Ferroptosis As Ultimate Target of Cancer Therapy	41
Emerging Chemical Biology of Protein Persulfidation	40
Preferential Secretion of Oxidation-Sensitive Proteins by Unconventional Pathways: Why is This Important for Inflammation?	40
Pathomechanistic Synergy Between Particulate Matter and Traffic Noise-Induced Cardiovascular Damage and the Classical Risk Factor Hypertension	40
Selenocompounds and Sepsis—Redox Bypass Hypothesis: Part B-Selenocompounds in the Management of Early Sepsis	40
Potential of Cytochrome P450, a Family of Xenobiotic Metabolizing Enzymes, in Cancer Therapy	39
The Emergence of Tumor-Initiating Cells in an Advanced Hypopharyngeal Tumor Model Exhibits Enhanced Angiogenesis and Nuclear Factor Erythroid 2-Related Factor 2-Associated Antioxidant Effects	39
Does SLC39A8 Ala391Thr Confer Risk of Chronic Liver Disease?	39
Alpha-Tocopherol from People to Plants Is an Essential Cog in the Metabolic Machinery	38
TXNIP Exacerbates the Senescence and Aging-Related Dysfunction of β Cells by Inducing Cell Cycle Arrest Through p38-p16/p21-CDK-Rb Pathway	37
Urinary Matrix Metalloproteinase 7 Activated by Oxidative Stress Predicts Kidney Prognosis in Myeloperoxidase–Antineutrophil Cytoplasmic Antibody-Associated Vasculitis	37
Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant	36
Beneficial Effects of Corylin on Metabolic Dysfunction-Associated Fatty Liver Disease	35
Soluble Carrier Transporters and Mitochondria in the Immunometabolic Regulation of Macrophages	35
Calcium Homeostasis in the Control of Mitophagy	34
SMAD4 Inhibits HO-1–Driven Ferroptosis Through Transcriptional Repression in Sepsis-Associated Acute Kidney Injury	34
Environmental Chemical-Induced Reactive Oxygen Species Generation and Immunotoxicity: A Comprehensive Review	34
Hydrogen Sulfide in Diabetic Complications Revisited: The State of the Art, Challenges, and Future Directions	34
Comparison of the Nitric Oxide Synthase Interactomes and S-Nitroso-Proteomes: Furthering the Case for Enzymatic S-Nitrosylation	34
Modulation of NRF2: Biological Dualism in Cancer, Targets and Possible Therapeutic Applications	33
Sirtuins: The NAD ⁺ -Dependent Multifaceted Modulators of Inflammation	33
What Is the Redox Potential of Ergothioneine?	32
L -Ergothioneine Attenuates Nephrolithiasis by Modulating Redox Signaling and Mitochondrial Function in Cystine and Calcium Oxalate Models	31
4-Hydroxynonenal Promotes Colorectal Cancer Progression Through Regulating Cancer Stem Cell Fate	31
Evidence for Constitutive Microbiota-Dependent Short-Term Control of Food Intake in Mice: Is There a Link with Inflammation, Oxidative Stress, Endotoxemia, and GLP-1?	31
Hypoxia-Induced Changes in Endothelial Cell Phenotype and Function	31
Oxygen Sensing in Innate Immune Cells: How Inflammation Broadens Classical Hypoxia-Inducible Factor Regulation in Myeloid Cells	31
Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome	31
Systemic Mutation of Ncf1 Ameliorates Obstruction-Induced Renal Fibrosis While Macrophage-Rescued NCF1 Further Alleviates Renal Fibrosis	30
Mechanistic Insights into Alternative Gene Splicing in Oxidative Stress and Tissue Injury	30
Cardiovascular Effects of Environmental Metal Antimony: Redox Dyshomeostasis as the Key Pathogenic Driver	29
Increased Neuronal Nitric Oxide Synthase in Alzheimer's Disease Mediates Spontaneous Calcium Signaling and Divergent Glutamatergic Calcium Responses	29
Impacts of Radiation on Metabolism and Vascular Cell Senescence	29
PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARα Activation in Rats Fed High-Fat Diet	29
α-Ketoglutarate Attenuates Hyperlipidemia-Induced Endothelial Damage by Activating the Erk-Nrf2 Signaling Pathway to Inhibit Oxidative Stress and Mitochondrial Dysfunction	29
Nicotinamide Adenine Dinucleotide Precursor Supplementation Modulates Neurite Complexity and Survival in Motor Neurons from Amyotrophic Lateral Sclerosis Models	29
Reflections of an Aging Free Radical Part 2: Meeting Inspirational People	29
ARS Forum Oxygen Sensing	29
NADPH Oxidases in Neurodegenerative Disorders: Mechanisms and Therapeutic Opportunities	29
Gasotransmitter-Mediated Cysteinome Oxidative Posttranslational Modifications: Formation, Biological Effects, and Detection	28
High Incidence of Lethal Ventricular Arrhythmia-Sudden Cardiac Death in Early Myocardial Ischemia: Critical Roles of Cross-Regulation Between Stresses and Calcium Imbalance	28
Tetrahydrobiopterin in Cell Function and Death Mechanisms	27
Correction to: Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages by Miao, et al.	27
ALOX15 Modulates Ferroptosis via the Reactive Oxygen Species-Mediated MAPK Pathway in Doxorubicin-Induced Cardiotoxicity	27
Reversal of Epigenetic Peroxisome Proliferator-Activated Receptor-γ Suppression by Diacerein Alleviates Oxidative Stress and Osteoarthritis in Mice	27
Ferroptosis in Tubular Epithelial Cells Across Distinct Renal Regions Is a Primary Causal Factor for Lupus Nephritis	26

Thrombosis and Aging: Fibrin Clot Properties and Oxidative Stress	26
Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage	26
A Novel Synthesized Cyclohexane-Hydroxytyrosol Derivative Suppresses Ovarian Cancer Cell Growth Through Inducing Reactive Oxidative Species and Blocking Autophagic Flux	25
Adaptive and Pathological Outcomes of Radiation Stress-Induced Redox Signaling	25
Epigenetic Control of Redox Pathways in Cancer Progression	25
Corrigendum to: “Angiotensin-Converting Enzyme-Dependent Intrarenal Angiotensin II Contributes to CTP: Phosphoethanolamine Cytidylyltransferase Downregulation, Mitochondrial	25
Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for Antioxidants & Redox Signaling	25
Mitochondrial Redox Signaling in O ₂ -Sensing Chemoreceptor Cells	25
Oxygen Sensing in Neurodegenerative Diseases: Current Mechanisms, Implication of Transcriptional Response, and Pharmacological Modulation	24
Urinary Thioredoxin as a Biomarker of Renal Redox Dysregulation and a Companion Diagnostic to Identify Responders to Redox-Modulating Therapeutics	24
Specialized Pro-Resolving Mediators Derived from N-3 Polyunsaturated Fatty Acids: Role in Metabolic Syndrome and Related Complications	23
Radiation-Induced Bystander Effect on the Genome of Bone Marrow Mesenchymal Stem Cells in Lung Cancer	23
Inhibition of Fatty Acid Translocase (FAT/CD36) Palmitoylation Enhances Hepatic Fatty Acid β-Oxidation by Increasing Its Localization to Mitochondria and Interaction with Long-Chain Acyl-CoA Synthetas	23
Hydrogen Sulfide Regulates Macrophage Function in Cardiovascular Diseases	23
Sirtuin 5 Alleviates Liver Ischemia/Reperfusion Injury by Regulating Mitochondrial Succinylation and Oxidative Stress	22
Thiol-Based Modification of MarR Protein VnrR Regulates Resistance Toward Nitrofuran in Vibrio cholerae By Promoting the Expression of a Novel Nitroreduc	22
Correction to: H ₂ S-Generating Cytosolic L-Cysteine Desulfhydrase and Mitochondrial D-Cysteine Desulfhydrase from Sweet P	22
Cellular Stress Response (Hormesis) in Response to Bioactive Nutraceuticals with Relevance to Alzheimer Disease	22
Reactive Oxygen Species/Reactive Nitrogen Species as Messengers in the Gut: Impact on Physiology and Metabolic Disorders	21
Physiological and Pathophysiological Roles of Thioredoxin Interacting Protein: A Perspective on Redox Inflammation and Metabolism	21
Advances in the Functions of Thioredoxin System in Central Nervous System Diseases	21
Adaptive Responses to Hypoxia and/or Hyperoxia in Humans	21
Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia	20
The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling	20
Reactive Sulfur Species in Human Diseases	20
Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health by Drosophila Model	20
High Uric Acid Orchestrates Ferroptosis to Promote Cardiomyopathy Via ROS-GPX4 Signaling	20
A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex	20
Hydrogen Sulfide and Functional Therapy: Novel Mechanisms from Epigenetics	19
Exploring the Molecular Interplay Between Oxygen Transport, Cellular Oxygen Sensing, and Mitochondrial Respiration	19
Alterations in Mitochondrial Function in Pulmonary Vascular Diseases	19
Role of Excessive Mitochondrial Fission in Seawater Immersion Aggravated Hemorrhagic Shock–Induced Cardiac Dysfunction and the Protective Effect of Mitochondrial Division Inhibitor-1	19
KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation Disease	19
Sestrin 2 Deficiency Exacerbates Noise-Induced Cochlear Injury Through Inhibiting ULK1/Parkin-Mediated Mitophagy	19
Pleiotropic Regulation of PGC-1α in Tumor Initiation and Progression	19
Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype	18
Modulation of Protein Disulfide Isomerase Functions by Localization: The Example of the Anterior Gradient Family	18
RNA and RNA Derivatives: Light and Dark Sides in Cancer Immunotherapy	18
Biological Sex As a Critical Variable in CD4 ⁺ Effector T Cell Function in Preclinical Models of Multiple Sclerosis	18
Histone demethylase KDM5D represses the proliferation, migration and invasion of hepatocellular carcinoma through the E2F1/TNNC1 axis	18
Succinate Activates Uncoupling Protein 2 to Suppress Neuroinflammation and Confer Protection Following Intracerebral Hemorrhage	18
Insights Into Antioxidant Strategies to Counteract Radiation-Induced Male Infertility	18
Hemoglobin Oxidation and Heme in Atherosclerosis—Link Between Intraplaque Hemorrhage and Progression of Complicated Atherosclerotic Lesion	18
ACE2 Activation in Intestinal Epithelial Cells Prevents Radiation-Induced Intestinal Injury	18
GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Attenuates Skeletal Muscle Abnormalities in a Murine Model of Duchenne Muscular Dystrophy	17
Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes	17
Mitochondria-Targeted Compounds to Assess and Improve Human Sperm Function	17
Mitochondrial DNA Copy Number: Linking Diabetes and Cancer	17
Sodium in Mitochondrial Redox Signaling	17
Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response	17
Non-thermal Plasma-Derived Reactive Oxygen Species Induces Cell Death in Radioresistant Head and Neck Cancer via the c-MET/STAT3 Pathway	17
Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPARγ at K339 by SIRT1	17
Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills	17
Sulfur Dioxide Alleviates Aortic Dissection Through Inhibiting Vascular Smooth Muscle Cell Phenotype Switch, Migration, and Proliferation via miR-184-3p/	17
CircGNAQ Promotes Intracranial Aneurysm Formation by Facilitating Vascular Smooth Muscle Cell Phenotypic Switching and Apoptosis	17
Peripubertal Bisphenol A Exposure Imparts Detrimental Age-Related Changes in Body Composition, Cognition, and Hydrogen Sulfide Production Capacities	17
RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα	17