OOIR: Observatory of International Research

Papers

(The TQCC of Antioxidants & Redox Signaling is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
The KEAP1-NRF2 system and neurodegenerative diseases	192
The Use of Multiplexing to Identify Cytokine and Chemokine Networks in the Immune-Inflammatory Response to Trauma	134
Mitochondrial Mechanisms in Immunity and Inflammatory Conditions: Beyond Energy Management	108
Oxidative Stress, Transfer RNA Metabolism, and Protein Synthesis	93
The Antioxidant Ergothioneine Alleviates Cisplatin-Induced Hearing Loss Through the Nrf2 Pathway	92
Disturbance of Fetal Growth by Azithromycin Through Induction of ER Stress in the Placenta	88
Does NLRP1 Inflammasome Activation in Immune Cells in Kidney Transplantation Relate with Donor Organ Age?	85
The redox protein HMGB1 in cell death and cancer	84
MicroRNA-Mediated Mitochondrial Dysfunction Is Involved in the Anti-triple-Negative Breast Cancer Cell Activity of Phytosesquiterpene Lactones	84
Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis	80
Metabolic and Redox Regulation of Cardiovascular Stem Cell Biology and Pathology	77
Redox Control of Integrin-Mediated Hepatic Inflammation in Systemic Autoimmunity	74
Cystathionine γ-Lyase Attenuates Vascular Smooth Muscle Cell Senescence via Foxm1-Gas1 Pathway to Mediate Arterial Stiffness	72
Blood–Labyrinth Barrier in Health and Diseases: Effect of Hormetic Nutrients	66
Oxygen in Metabolic Dysfunction and Its Therapeutic Relevance	65
Mild Therapeutic Hypothermia and Putative Mechanisms of Hair Cell Survival in the Cochlea	65
Procyanidin B2 Promotes Intestinal Injury Repair and Attenuates Colitis-Associated Tumorigenesis via Suppression of Oxidative Stress in Mice	62
ERO1-PDI Redox Signaling in Health and Disease	60
Impact of Mitochondrial Architecture, Function, Redox Homeostasis, and Quality Control on Organismic Aging: Lessons from a Fungal Model System	57
Modes of Mitochondrial Reactive Oxygen Species Production in Inflammation	57
Exosomal Prolactin-Induced Protein Inhibits the Activation of cGMP/PKG Pathway Mediated by ATP2B2 to Promote Myocardial Fibrosis in Atrial Fibrillation	54
Pathological Impact of Redox Post-Translational Modifications	54
The Role of Perivascular Adipose Tissue-Derived Hydrogen Sulfide in the Control of Vascular Homeostasis	53
Regulation of Erythroid Differentiation via the HIF1α-NFIL3-PIM1 Signaling Axis Under Hypoxia	52
Ferroptosis As Ultimate Target of Cancer Therapy	51

Contribution of Mitochondria to Insulin Secretion by Various Secretagogues	51
Nogo-B Promotes Endoplasmic Reticulum Stress-Mediated Autophagy in Endothelial Cells of Diabetic Nephropathy	48
Modulation of Innate Immune Memory Dynamics by Subcellular Reactive Oxygen Species	47
Redox Signaling and Stress in Inherited Myopathies	44
Emerging Chemical Biology of Protein Persulfidation	43
Reactive Oxygen Species and Their Consequences on the Structure and Function of Mammalian Spermatozoa	43
Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma	43
Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron	42
Altered Metabolism in Alzheimer Disease Brain: Role of Oxidative Stress	40
Potential of Cytochrome P450, a Family of Xenobiotic Metabolizing Enzymes, in Cancer Therapy	39
Selenocompounds and Sepsis—Redox Bypass Hypothesis: Part B-Selenocompounds in the Management of Early Sepsis	39
Soluble Carrier Transporters and Mitochondria in the Immunometabolic Regulation of Macrophages	39
Does SLC39A8 Ala391Thr Confer Risk of Chronic Liver Disease?	38
Liver Sinusoidal Endothelial Cells at the Crossroad of Iron Overload and Liver Fibrosis	38
PDK4 Decrease Neuronal Apoptosis via Inhibiting ROS-ASK1/P38 Pathway in Early Brain Injury After Subarachnoid Hemorrhage	37
Alpha-Tocopherol from People to Plants Is an Essential Cog in the Metabolic Machinery	37
Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant	37
The Reactive Species Interactome in the Brain	36
Urinary Matrix Metalloproteinase 7 Activated by Oxidative Stress Predicts Kidney Prognosis in Myeloperoxidase–Antineutrophil Cytoplasmic Antibody-Associated Vasculitis	36
Maternal P7C3-A20 Treatment Protects Offspring from Neuropsychiatric Sequelae of Prenatal Stress	36
Chemiluminescence Measurement of Reactive Sulfur and Nitrogen Species	35
TXNIP Exacerbates the Senescence and Aging-Related Dysfunction of β Cells by Inducing Cell Cycle Arrest Through p38-p16/p21-CDK-Rb Pathway	35
Pathomechanistic Synergy Between Particulate Matter and Traffic Noise-Induced Cardiovascular Damage and the Classical Risk Factor Hypertension	35
Correction to: Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling, by Pires et al. Ant	35
Are Circulating Fibroblast Growth Factor 21 and N-Terminal Prohormone of Brain Natriuretic Peptide Promising Novel Biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?	34
4-Hydroxynonenal Promotes Colorectal Cancer Progression Through Regulating Cancer Stem Cell Fate	34
Preferential Secretion of Oxidation-Sensitive Proteins by Unconventional Pathways: Why is This Important for Inflammation?	34
Mechanistic Insights into Alternative Gene Splicing in Oxidative Stress and Tissue Injury	34
The Emergence of Tumor-Initiating Cells in an Advanced Hypopharyngeal Tumor Model Exhibits Enhanced Angiogenesis and Nuclear Factor Erythroid 2-Related Factor 2-Associated Antioxidant Effects	34
Systemic Mutation of Ncf1 Ameliorates Obstruction-Induced Renal Fibrosis While Macrophage-Rescued NCF1 Further Alleviates Renal Fibrosis	34
Modulation of NRF2: Biological Dualism in Cancer, Targets and Possible Therapeutic Applications	32
Evidence for Constitutive Microbiota-Dependent Short-Term Control of Food Intake in Mice: Is There a Link with Inflammation, Oxidative Stress, Endotoxemia, and GLP-1?	31
What Is the Redox Potential of Ergothioneine?	31
Oxygen Sensing in Innate Immune Cells: How Inflammation Broadens Classical Hypoxia-Inducible Factor Regulation in Myeloid Cells	31
Calcium Homeostasis in the Control of Mitophagy	31
Targeting Toll-Like Receptors in Sepsis: From Bench to Clinical Trials	30
Sirtuins: The NAD⁺-Dependent Multifaceted Modulators of Inflammation	30
Hydrogen Sulfide in Diabetic Complications Revisited: The State of the Art, Challenges, and Future Directions	29
Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome	29
Environmental Chemical-Induced Reactive Oxygen Species Generation and Immunotoxicity: A Comprehensive Review	29
Comparison of the Nitric Oxide Synthase Interactomes and S-Nitroso-Proteomes: Furthering the Case for Enzymatic S-Nitrosylation	29
Reflections of an Aging Free Radical Part 2: Meeting Inspirational People	28
ARS Forum Oxygen Sensing	28
Vitamin C (Ascorbate) and Redox Topics in Cancer	28
PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARα Activation in Rats Fed High-Fat Diet	27
Signal Transduction and Molecular Regulation in Fatty Liver Disease	27
NADPH Oxidases in Neurodegenerative Disorders: Mechanisms and Therapeutic Opportunities	26
The Impact of Oxygen Availability and Multilineage Communication on Organoid Maturation	26
Nicotinamide Adenine Dinucleotide Precursor Supplementation Modulates Neurite Complexity and Survival in Motor Neurons from Amyotrophic Lateral Sclerosis Models	26
Cardiovascular Effects of Environmental Metal Antimony: Redox Dyshomeostasis as the Key Pathogenic Driver	26

Reversal of Epigenetic Peroxisome Proliferator-Activated Receptor-γ Suppression by Diacerein Alleviates Oxidative Stress and Osteoarthritis in Mice	26
Tetrahydrobiopterin in Cell Function and Death Mechanisms	25
α-Ketoglutarate Attenuates Hyperlipidemia-Induced Endothelial Damage by Activating the Erk-Nrf2 Signaling Pathway to Inhibit Oxidative Stress and Mitochondrial Dysfunction	25
Moonlighting Metabolic Enzymes in Cancer: New Perspectives on the Redox Code	25
Increased Neuronal Nitric Oxide Synthase in Alzheimer's Disease Mediates Spontaneous Calcium Signaling and Divergent Glutamatergic Calcium Responses	25
Impacts of Radiation on Metabolism and Vascular Cell Senescence	25
The Protective Role of the Heme Catabolic Pathway in Hepatic Disorders	24
Specialized Pro-Resolving Mediators Derived from N-3 Polyunsaturated Fatty Acids: Role in Metabolic Syndrome and Related Complications	24
Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for Antioxidants & Redox Signaling	24
Urinary Thioredoxin as a Biomarker of Renal Redox Dysregulation and a Companion Diagnostic to Identify Responders to Redox-Modulating Therapeutics	24
Gasotransmitter-Mediated Cysteinome Oxidative Posttranslational Modifications: Formation, Biological Effects, and Detection	24
Thiol-Based Modification of MarR Protein VnrR Regulates Resistance Toward Nitrofuran in Vibrio cholerae By Promoting the Expression of a Novel Nitroreductase VnrA and of NO-Detoxifying Enzyme H	23
Adaptive and Pathological Outcomes of Radiation Stress-Induced Redox Signaling	23
Oxygen Sensing in Neurodegenerative Diseases: Current Mechanisms, Implication of Transcriptional Response, and Pharmacological Modulation	23
Correction to: H₂S-Generating Cytosolic L-Cysteine Desulfhydrase and Mitochondrial D-Cysteine Desulfhydrase from Sweet Pepper (Capsicum annuum L.) Are Regulated During Fruit R	23
Secreted Protein Acidic and Cysteine Rich Matricellular Protein is Enriched in the Bioactive Fraction of the Human Vascular Pericyte Secretome	23
Radiation-Induced Bystander Effect on the Genome of Bone Marrow Mesenchymal Stem Cells in Lung Cancer	22
Divergent Sepsis Pathophysiology in Older Adults	22
Development of Hydropersulfide Donors to Study Their Chemical Biology	22
Epigenetic Control of Redox Pathways in Cancer Progression	22
A Novel Synthesized Cyclohexane-Hydroxytyrosol Derivative Suppresses Ovarian Cancer Cell Growth Through Inducing Reactive Oxidative Species and Blocking Autophagic Flux	21
Mitochondrial Redox Signaling in O₂-Sensing Chemoreceptor Cells	21
Sirtuin 5 Alleviates Liver Ischemia/Reperfusion Injury by Regulating Mitochondrial Succinylation and Oxidative Stress	20
Pyroptosis and Redox Balance in Kidney Diseases	20
A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex	20
Circulating Extracellular Vesicles Contain Liver-Derived RNA Species as Indicators of Severe Cholestasis-Induced Early Liver Fibrosis in Mice	20
Hydrogen Sulfide Regulates Macrophage Function in Cardiovascular Diseases	20
Adaptive Responses to Hypoxia and/or Hyperoxia in Humans	20
Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health byDrosophilaModel	20
Inhibition of Fatty Acid Translocase (FAT/CD36) Palmitoylation Enhances Hepatic Fatty Acid β-Oxidation by Increasing Its Localization to Mitochondria and Interaction with Long-Chain Acyl-CoA Synthetas	20
Thrombosis and Aging: Fibrin Clot Properties and Oxidative Stress	20
CELLULAR STRESS RESPONSE (HORMESIS) IN RESPONSE TO BIOACTIVE NUTRACEUTICALS WITH RELEVANCE TO ALZHEIMER DISEASE	20
The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling	20
High Uric Acid Orchestrates Ferroptosis to Promote Cardiomyopathy Via ROS-GPX4 Signaling	19
Reactive Sulfur Species in Human Diseases	19
Advances in the Functions of Thioredoxin System in Central Nervous System Diseases	19
Hydrogen Sulfide and Functional Therapy: Novel Mechanisms from Epigenetics	19
Reactive Oxygen Species/Reactive Nitrogen Species as Messengers in the Gut: Impact on Physiology and Metabolic Disorders	19
Physiological and Pathophysiological Roles of Thioredoxin Interacting Protein: A Perspective on Redox Inflammation and Metabolism	19
Biological Sex As a Critical Variable in CD4⁺Effector T Cell Function in Preclinical Models of Multiple Sclerosis	18
Pleiotropic Regulation of PGC-1α in Tumor Initiation and Progression	18
Exploring the Molecular Interplay Between Oxygen Transport, Cellular Oxygen Sensing, and Mitochondrial Respiration	18
Targeting Neuroimmune Interactions in Diabetic Neuropathy with Nanomedicine	18
The Aging Liver: Redox Biology and Liver Regeneration	18
Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype	18
Alterations in Mitochondrial Function in Pulmonary Vascular Diseases	18
Methods for Suppressing Hydrogen Sulfide in Biological Systems	18
Succinate Activates Uncoupling Protein 2 to Suppress Neuroinflammation and Confer Protection Following Intracerebral Hemorrhage	18
Modulation of Protein Disulfide Isomerase Functions by Localization: The Example of the Anterior Gradient Family	18
Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging	18
KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation Disease	18
Impact of Acute and Chronic Psychosocial Stress on Vascular Inflammation	18
Role of Excessive Mitochondrial Fission in Seawater Immersion Aggravated Hemorrhagic Shock–Induced Cardiac Dysfunction and the Protective Effect of Mitochondrial Division Inhibitor-1	17
Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease	17
Histone demethylase KDM5D represses the proliferation, migration and invasion of hepatocellular carcinoma through the E2F1/TNNC1 axis	17
Sulfur Dioxide Alleviates Aortic Dissection Through Inhibiting Vascular Smooth Muscle Cell Phenotype Switch, Migration, and Proliferation via miR-184-3p/Cyp26b1 Axis	17
Sestrin 2 Deficiency Exacerbates Noise-Induced Cochlear Injury Through Inhibiting ULK1/Parkin-Mediated Mitophagy	17
Nitric oxide derived from cytoglobin-deficient hepatic stellate cells causes suppression of cytochrome c oxidase activity in hepatocytes	17
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway	17
Insights Into Antioxidant Strategies to Counteract Radiation-Induced Male Infertility	17
RNA and RNA Derivatives: Light and Dark Sides in Cancer Immunotherapy	17
Selenocompounds and Sepsis: Redox Bypass Hypothesis for Early Diagnosis and Treatment: Part A—Early Acute Phase of Sepsis: An Extraordinary Redox Situation (Leukocyte/Endothelium Interaction Leading t	17
Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response	16
Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills	16
Spatiotemporal Characteristics Determining the Multifaceted Nature of Reactive Oxygen, Nitrogen, and Sulfur Species in Relation to Proton Homeostasis	16
Stem Cells and Their Cardiac Derivatives for Cardiac Tissue Engineering and Regenerative Medicine	16
Stable and Temporary Enzyme Complexes and Metabolons Involved in Energy and Redox Metabolism	16
Sodium in Mitochondrial Redox Signaling	16
Recent Advances in KEAP1/NRF2-Targeting Strategies by Phytochemical Antioxidants, Nanoparticles, and Biocompatible Scaffolds for the Treatment of Diabetic Cardiovascular Complications	16
Mitochondrial DNA Copy Number: Linking Diabetes and Cancer	16
H₂S: A Simple Molecule with Multifaceted Biochemistry and Functions	16
Cell Death-Osis of Dopaminergic Neurons and the Role of Iron in Parkinson's Disease	16
NAD⁺, Axonal Maintenance, and Neurological Disease	16
Aging and Antithrombotic Treatment	16
Intrinsic and Induced Neuronal Regeneration in the Mammalian Retina	16