American Journal of Physiology-Renal Physiology

Article	Citations
Chronic infusion of the tryptophan metabolite kynurenine increases mean arterial pressure in male Sprague-Dawley rats	57
Role of the CDKL1-SOX11 signaling axis in acute kidney injury	53
Accuracy and processing time of kidney volume measurement methods in rodents polycystic kidney disease models: superiority of semiautomated kidney segmentation	52
Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function	35
Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice	35
“Idiopathic” minimal change nephrotic syndrome: a podocyte mystery nears the end	34
First Author Highlights	33
Corrigendum for Jang et al., volume 326, 2024, p. F69	32
First Author Highlights	31
A mathematical model of the rat kidney. IV. Whole kidney response to hyperkalemia	30
Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism	29
Lack of renoprotective effects by long-term PCSK9 and SGLT2 inhibition using alirocumab and empagliflozin in obese ZSF1 rats	29
Perinatal asphyxia leads to acute kidney damage and increased renal susceptibility in adulthood	28
Rapid development of vasopressin resistance in dietary K+ deficiency	28
Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth	28
Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species	27
C-terminal fragment of fibroblast growth factor 23 improves heart function in murine models of high intact fibroblast growth factor 23	25
First Author Spotlight	25
First Author Highlights	25
Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes	25
Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression	24
Redox regulation in diabetic kidney disease	24
Pax inhibition: stressing proximal tubule for successful repair	23
Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury	23
Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury	22

A brief history of the cortical thick ascending limb: a systems-biology perspective	22
A combination of β-hydroxybutyrate and citrate ameliorates disease progression in a rat model of polycystic kidney disease	21
Splenocyte transfer from hypertensive donors eliminates premenopausal female protection from ANG II-induced hypertension	21
Porcine models of acute kidney injury	21
Methylseq, single-nuclei RNAseq, and discovery proteomics identify pathways associated with nephron-deficit CKD in the HSRA rat model	21
Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarker in autosomal dominant tubulointerstitial kidney disease	20
Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction	20
Tubular dysfunction impairs renal excretion of pseudouridine in diabetic kidney disease	20
Mapping kidney tubule diameter ex vivo by diffusion MRI	20
Defining protein expression in the kidney at large scale: from antibody validation to cytometry analysis	19
Perspective on G protein-coupled receptors in renal physiology	19
Polygenic genetic variation affecting antibody formation underlies hypertensive renal injury in the stroke-prone spontaneously hypertensive rat	19
Renal cell markers: lighthouses for managing renal diseases	19
Characterization of a functional V1B vasopressin receptor in the male rat kidney: evidence for cross talk between V1B and V2 receptor signaling pathways	19
β2-Adrenergic receptor agonists: a new treatment for diabetic kidney disease?	19
Hints for a kidney lactate shuttle and lactomone	19
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy	18
Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy	18
A naturally occurring FXR agonist, alisol B 23-acetate, protects against renal ischemia-reperfusion injury	18
Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats	18
First Author Highlights	18
Hyperphosphatemia and zinc deficiency in chronic kidney disease: unpacking their interconnected roles and nutritional implications	18
Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase	18
Optogenetic urothelial cell stimulation induces bladder contractions and pelvic nerve afferent firing	18
Kidney hemodynamic function in men and postmenopausal women with type 2 diabetes and preserved kidney function	18
Prolonged unilateral renal ischemia-reperfusion as a model for acute to chronic kidney injury in female mice	18
Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age	18
Angiotensin type 2 receptor activation limits kidney injury during the early phase and induces Treg cells during the late phase of renal ischemia	17
Dysregulation of the sensory and regulatory pathways controlling cellular iron metabolism in unilateral obstructive nephropathy	17
15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction	17
Overview of acute kidney manifestations and management of patients with COVID-19	17
Cilia-deficient renal tubule cells are primed for injury with mitochondrial defects and aberrant tryptophan metabolism	17
Angiotensin in the acute and chronic responses to unilateral nephrectomy	17
Delayed graft function post renal transplantation: a review on animal models and therapeutics	16
Inhibition of hypoxia-inducible factor-prolyl hydroxylation protects from cyclophosphamide-induced bladder injury and urinary dysfunction	16
Ubiquitination of NKCC2 by the cullin-RING E3 ubiquitin ligase family in the thick ascending limb of the loop of Henle	16
First Author Spotlight	16
Novel insight on physiological regulation of the Cl−/HCO3− exchanger pendrin	16
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats	15
Commensal microbiota regulate aldosterone	15
Corrigendum for Fu et al., volume 317, 2019, p. F1582–F1592	15
Macrophage angiotensin AT2 receptor activation is protective against early phases of LPS-induced acute kidney injury	15
Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight	15
Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron	15
Influence of proteolytic cleavage of ENaC’s γ subunit upon Na+ and K+ handling	15
High dietary K+ intake inhibits proximal tubule transport	14
Impaired nitric oxide mechanisms underlying lower urinary tract dysfunction in aging rats	14
Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury	14
Recent advances in understanding the kidney circadian clock mechanism	14
High baseline ROMK activity in the mouse late distal convoluted and early connecting tubule probably contributes to aldosterone-independent K+ secretion	14

Predicting oxygen tension along the ureter	13
First Author Spotlight	13
Psychotropic drugs upregulate aquaporin-2 via vasopressin-2 receptor/cAMP/protein kinase A signaling in inner medullary collecting duct cells	13
Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease	13
Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice	13
TNIK depletion induces inflammation and apoptosis in injured renal proximal tubule epithelial cells	12
Proximal tubule cyclophilin D mediates kidney fibrogenesis in obstructive nephropathy	12
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension	12
The kidney in health and disease in 2022: Gaps in and opportunities for new knowledge	12
Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging	12
First Author Spotlight	12
Physiology assays in human kidney organoids	11
Regulation of kidney mitochondrial function by caloric restriction	11
Inducible deletion of the prostaglandin EP3 receptor in kidney tubules of male and female mice has no major effect on water homeostasis	11
Pendrin regulation is prioritized by anion in high-potassium diets	11
Kir4.1/Kir5.1 of distal convoluted tubule is required for short-term angiotensin-II-induced stimulation of Na-Cl cotransporter	11
Sacubitril/valsartan treatment has differential effects in modulating diabetic kidney disease in db/db mice and KKAy mice compared with valsartan treatment	11
Amiloride lowers plasma TNF and interleukin-6 but not interleukin-17A in patients with hypertension and type 2 diabetes	11
Exogenous pericyte delivery protects the mouse kidney from chronic ischemic injury	11
Sex differences in dietary sodium evoked NCC regulation and blood pressure in male and female Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats	11
The impact of maternal obesity on polycystic kidney disease progression in a mouse model	11
A novel functional role for the classic CNS neurotransmitters, GABA, glycine, and glutamate, in the kidney: potent and opposing regulators of the renal vasculature	11
Sex-disaggregated analysis of acute kidney injury in hospitalized children with sickle cell anemia in Uganda	11
A brief harvesting-freezing delay significantly alters the kidney metabolome and leads to false positive and negative results	11
Revisiting voltage-coupled H+ secretion in the collecting duct	11
Downloadable Tool for Modeling of Salt, Urea and Water Transport in a Renal Tubule Segment: Application to the DCT	11
Impaired hemodynamic renal reserve response following recovery from established acute kidney injury and improvement by hydrodynamic isotonic fluid delivery	11
Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort	10
Chronic kidney disease amplifies severe kidney injury and mortality in a mouse model of skin arsenical exposure	10
Furin-Mediated Modification Is Required for Epithelial Sodium Channel-Activating Activity of Soluble (Pro)Renin Receptor in Cultured Collecting Duct Cells	10
Proteinuria is accompanied by intratubular complement activation and apical membrane deposition of C3dg and C5b-9 in kidney transplant recipients	10
Prevention of hypertension-induced renal vascular dysfunction through a p66Shc-targeted mechanism	10
Renal claudin-14 expression is not required for regulating Mg2+ balance in mice	10
Male Akita mice develop signs of bladder underactivity independent of NLRP3 as a result of a decrease in neurotransmitter release from efferent neurons	10
Cystinosin-deficient rats recapitulate the phenotype of nephropathic cystinosis	10
Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress	10
Injury in nonaged podocytes as an accelerator of glomerular aging	10
JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice	10
Bayesian mapping of protein kinases to vasopressin-regulated phosphorylation sites in renal collecting duct	10
First Author Highlights	10
Antibiotic-induced microbiome depletion alters renal glucose metabolism and exacerbates renal injury after ischemia-reperfusion injury in mice	10
Influence of carnosine and carnosinase-1 on diabetes-induced afferent arteriole vasodilation: implications for glomerular hemodynamics	10
CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes	10
Practical notes on popular statistical tests in renal physiology	10
Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent manner	10
HMGB1 drives T-cell activation in hypertensive males and females	10
Pretreatment with a novel Toll-like receptor 4 agonist attenuates renal ischemia-reperfusion injury	10
Transcription factor HNF1β controls a transcriptional network regulating kidney cell structure and tight junction integrity	9
Effects of SGLT2 inhibitor and dietary NaCl on glomerular hemodynamics assessed by micropuncture in diabetic rats	9
Image analysis techniques to map pyramids, pyramid structure, glomerular distribution, and pathology in the intact human kidney from 3-D MRI	9
First Author Highlights	9
Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity	9
Flow-dependent transport processes 2024: filtration, absorption, secretion	9
Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy	9
β2-Adrenergic receptor agonists as a treatment for diabetic kidney disease	9
Novel method for kinetic analysis applied to transport by the uniporter OCT2	9
HIF-1α is transcriptionally regulated by NF-κB in acute kidney injury	9
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney	9
A stressed barrier left behind: stochastic podocyte ablation triggers secondary injury	9
Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program	9
IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage	9
Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury	9
Creatinine clearance is maintained in a range of wet-bulb globe temperatures and work-rest ratios during simulated occupational heat stress	9
KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury	9
Promises and challenges of miRNA therapeutics	9
Mitochondrial dysfunction in the pathophysiology of renal diseases	9
Mechanisms of decreased tubular flow-induced nitric oxide in Dahl salt-sensitive rat thick ascending limbs	9
The Indiana O’Brien Center for Advanced Renal Microscopic Analysis	9
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms’ tumor 1 expression in cultured human podocytes	9
Postoperative acute kidney injury after volatile or intravenous anesthesia: a meta-analysis	9
High dietary salt intake increases urinary NGAL excretion and creatinine clearance in healthy young adults	8
A mathematical model of the rat kidney. III. Ammonia transport	8
Pathways and parameters of sacral neuromodulation in rats	8
Endothelin-1 signaling in the kidney: recent advances and remaining gaps	8
Kidney functional reserve helps early detection of subclinical chronic kidney disease	8
Role of protease-activated receptor 4 in mouse models of acute and chronic kidney injury	8
IFT88 deficiency in proximal tubular cells exaggerates cisplatin-induced injury by suppressing autophagy	8
Longitudinal intravital microscopy of the mouse kidney: inflammatory responses to abdominal imaging windows	8
Indirect podocyte injury manifested in a partial podocytectomy mouse model	8
Assays to enhance metabolic phenotyping in the kidney	8

Vascular control of kidney epithelial transporters	8
Machine-perfused donor kidneys as a source of human renal endothelial cells	8
First Author Spotlight	8
Diffusion tensor MRI is sensitive to fibrotic injury in a mouse model of oxalate-induced chronic kidney disease	8
The degree of aortic occlusion in the setting of trauma alters the extent of acute kidney injury associated with mitochondrial preservation	8
Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation	8
First Author Highlights	8
Tacrolimus induces fibroblast-to-myofibroblast transition via a TGF-β-dependent mechanism to contribute to renal fibrosis	8
Fasting-induced HMGCS2 expression in the kidney does not contribute to circulating ketones	8
Faster bladder filling in rats reduces detrusor overactivity but worsens (i.e., decreases) bladder compliance	8
Predicting sex differences in the effects of diuretics in renal epithelial transport during angiotensin II-induced hypertension	8
Identification of cell division cycle protein 20 in various forms of acute and chronic kidney injury in mice	8
A comparative modeling study of the mitochondrial function of the proximal tubule and thick ascending limb cells in the rat kidney	7
The evolving concepts of KS-WNK1 effect on NCC activity	7
Metabolic acidosis regulates RGS16 and G protein signaling in osteoblasts	7
Corrigendum for McKinzie et al., volume 326, 2024, p. F644–F660	7
Cullin 3 mutant causing familial hyperkalemic hypertension lacks normal activity in the kidney	7
Myo-inositol oxygenase in cadmium-induced kidney injury	7
SGLT2 inhibitors: not every drug has the same effect	7
Corrigendum for Martínez-Rojas et al., volume 323, 2022, p. F425–F434	7
Western diet exacerbates a murine model of Balkan nephropathy	7
Metabolomic profiling to identify early urinary biomarkers and metabolic pathway alterations in autosomal dominant polycystic kidney disease	7
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy	7
The role of Gata3 in renin cell identity	7
2024 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section	7
The knock-out of paracingulin attenuates hypertension through modulation of kidney ion transport	7
Sex differences in circadian regulation of kidney function of the mouse	7
Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury	7
Specialized proresolution mediators in the bladder: annexin-A1 normalizes inflammation and bladder dysfunction during bladder outlet obstruction	7
Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice	6
The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease	6
Endothelial dysfunction in the aging kidney	6
Role of coagulation in persistent renal ischemia following reperfusion in an animal model	6
Intestinal barrier function declines during polycystic kidney disease progression	6
Renal calcium and magnesium handling during pregnancy: modeling and analysis	6
KV7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure	6
First Author Highlights	6
Deletion of renal Nedd4-2 abolishes the effect of high sodium intake (HS) on Kir4.1, ENaC, and NCC and causes hypokalemia during high HS	6
Circadian gene expression in mouse renal proximal tubule	6
Hepatic and proximal tubule angiotensinogen play distinct roles in kidney dysfunction, glomerular and tubular injury, and fibrosis progression	6
Transition from acute kidney injury to chronic kidney disease: mechanisms, models, and biomarkers	6
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake	6
Expression and distribution of MUC1 in the developing and adult kidney	6
Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damage	6
Kidney stone formation in a novel murine model of polycystic kidney disease	6
Role of the renal androgen receptor in sex differences in ammonia metabolism	6
The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu)	6
PLVAP: the new villain in glomerular endothelial cell injury	6
Synaptopodin deficiency exacerbates kidney disease in a mouse model of Alport syndrome	6
Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes	6
Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na+ and K+	6
LncRNA GAS5 protects against TGF-β-induced renal fibrosis via the Smad3/miRNA-142-5p axis	6
Endothelin receptor B is required for the blood pressure-lowering effect of G protein-coupled estrogen receptor 1 in ovariectomized rats	6
Corrigendum for Hu QH et al., Volume 297, 2009, p. F1080–F1091	6
Podocyte injury at young age causes premature senescence and worsens glomerular aging	6
Histamine receptors rapidly desensitize without altering nerve-evoked contractions in murine urinary bladder smooth muscle	6
Sex-specific modulation of renal epigenetic and injury markers in aging kidney	6
Anatomic and functional evidence for renal autonomic innervation in normotensive and hypertensive rats	6
Effect of sex chromosome complement versus gonadal hormones on abundance of renal transporters	6
NMR-based serum and urine metabolomic profile reveals suppression of mitochondrial pathways in experimental sepsis-associated acute kidney injury	6
Tips on navigating the first year of graduate school for individuals from historically excluded backgrounds	5
Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease	5
Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect	5
Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice	5
Impact of bedding on Dahl salt-sensitive hypertension and renal damage	5
Myeloid-specific ferritin light chain deletion does not exacerbate sepsis-associated AKI	5
Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity	5
Induction of plasmalemmal vesicle-associated protein exacerbates glomerular endothelial injury in thrombotic microangiopathy	5
Endothelial cells: potential novel regulators of renal inflammation	5
Could an intrarenal Cori cycle participate in the urinary concentrating mechanism?	5
Therapeutic α-1-microglobulin ameliorates kidney ischemia-reperfusion injury	5
Generation of Atp6v1g3-Cre mice for investigation of intercalated cells and the collecting duct	5
Raising serum uric acid with a uricase inhibitor worsens PKD in rat and mouse models	5
The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials	5
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression	5
Modulation of blood pressure by dietary potassium and sodium: sex differences and modeling analysis	5
Guidelines on antibody use in physiology research	5
Amiloride evokes significant natriuresis and weight loss in kidney transplant recipients with and without albuminuria	5
Renal mass reduction increases the response to exogenous insulin independent of acid-base status or plasma insulin levels in rats	5
Autophagy and mitophagy: physiological implications in kidney inflammation and diseases	5
Role of the SLC22A17/lipocalin-2 receptor in renal endocytosis of proteins/metalloproteins: a focus on iron- and cadmium-binding proteins	5
The Janus view: dual roles for hypoxia-inducible factor in renal repair after acute kidney injury	5
First Author Spotlight	5
The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology	5
Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity	5
Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation and membrane accumulation after EGFR inhibition with erlotinib	5
Wilms’ tumor gene 1: lessons from the interface between kidney development and cancer	5
The FSGS protein actinin-4 interacts with NKCC2 to regulate thick ascending limb NaCl reabsorption	5
Chronic environmental hypoxia attenuates innate immunity activation and renal injury in two CKD models	5
Single-cell mRNA profiling reveals changes in solute carrier expression and suggests a metabolic switch during zebrafish pronephros development	5
Caspase-3-dependent peritubular capillary dysfunction is pivotal for the transition from acute to chronic kidney disease after acute ischemia-reperfusion injury	5
Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria	5
Proximal Tubule Pannexin 1 Contributes to Mitochondrial Dysfunction and Cell Death During Acute Kidney Injury	5
Angiotensin (1–7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats	5
Toward a full-scale model of renal hemodynamics using a reconstructed vascular tree	4