American Journal of Physiology-Renal Physiology

Article	Citations
First Author Highlights	56
Accuracy and processing time of kidney volume measurement methods in rodents polycystic kidney disease models: superiority of semiautomated kidney segmentation	40
Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function	39
First Author Highlights	39
Corrigendum for Jang et al., volume 326, 2024, p. F69	37
First Author Highlights	37
Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth	36
Exercise sensitizes the pressure diuresis response: shifting immune landscapes may underlie renal adaptations	33
Lack of renoprotective effects by long-term PCSK9 and SGLT2 inhibition using alirocumab and empagliflozin in obese ZSF1 rats	31
“Idiopathic” minimal change nephrotic syndrome: a podocyte mystery nears the end	29
Chronic infusion of the tryptophan metabolite kynurenine increases mean arterial pressure in male Sprague-Dawley rats	28
C-terminal fragment of fibroblast growth factor 23 improves heart function in murine models of high intact fibroblast growth factor 23	28
Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism	28
Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice	28
A mathematical model of the rat kidney. IV. Whole kidney response to hyperkalemia	28
Role of the CDKL1-SOX11 signaling axis in acute kidney injury	27
Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species	26
Perinatal asphyxia leads to acute kidney damage and increased renal susceptibility in adulthood	26
Polygenic genetic variation affecting antibody formation underlies hypertensive renal injury in the stroke-prone spontaneously hypertensive rat	25
First Author Highlights	25
β2-Adrenergic receptor agonists: a new treatment for diabetic kidney disease?	24
Perspective on G protein-coupled receptors in renal physiology	24
Defining protein expression in the kidney at large scale: from antibody validation to cytometry analysis	24
Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes	23
A combination of β-hydroxybutyrate and citrate ameliorates disease progression in a rat model of polycystic kidney disease	23

Pax inhibition: stressing proximal tubule for successful repair	22
A brief history of the cortical thick ascending limb: a systems-biology perspective	22
Splenocyte transfer from hypertensive donors eliminates premenopausal female protection from ANG II-induced hypertension	21
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy	21
Renal cell markers: lighthouses for managing renal diseases	21
Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury	20
Optogenetic urothelial cell stimulation induces bladder contractions and pelvic nerve afferent firing	20
Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury	20
Redox regulation in diabetic kidney disease	19
Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase	18
A key role of AT1a receptors and Na+/H+ exchanger 3 in the proximal tubules in angiotensin II-induced and two-kidney, one-clip Goldblatt hypertension	18
Methylseq, single-nuclei RNAseq, and discovery proteomics identify pathways associated with nephron-deficit CKD in the HSRA rat model	18
The nephronophthisis protein GLIS2/NPHP7 is required for the DNA damage response in kidney tubular epithelial cells	18
Tubular dysfunction impairs renal excretion of pseudouridine in diabetic kidney disease	18
Hyperphosphatemia and zinc deficiency in chronic kidney disease: unpacking their interconnected roles and nutritional implications	17
Valosin-containing protein in ciliary morphology: a novel target in ADPKD	17
First Author Highlights	17
Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age	17
Race and sex differences in pressor response to laboratory stressors in patients with chronic kidney disease	17
Inhibition of hypoxia-inducible factor-prolyl hydroxylation protects from cyclophosphamide-induced bladder injury and urinary dysfunction	16
Delayed graft function post renal transplantation: a review on animal models and therapeutics	16
Angiotensin in the acute and chronic responses to unilateral nephrectomy	16
Cilia-deficient renal tubule cells are primed for injury with mitochondrial defects and aberrant tryptophan metabolism	16
Dysregulation of the sensory and regulatory pathways controlling cellular iron metabolism in unilateral obstructive nephropathy	16
Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy	16
15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction	15
Editorial Board	15
Novel insight on physiological regulation of the Cl−/HCO3− exchanger pendrin	15
A naturally occurring FXR agonist, alisol B 23-acetate, protects against renal ischemia-reperfusion injury	15
First Author Spotlight	15
Ubiquitination of NKCC2 by the cullin-RING E3 ubiquitin ligase family in the thick ascending limb of the loop of Henle	15
Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats	15
Prolonged unilateral renal ischemia-reperfusion as a model for acute to chronic kidney injury in female mice	15
Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice	14
Corrigendum for Fu et al., volume 317, 2019, p. F1582–F1592	14
High dietary K+ intake inhibits proximal tubule transport	14
Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight	14
Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury	14
Impaired nitric oxide mechanisms underlying lower urinary tract dysfunction in aging rats	13
Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease	13
Inducible Avp Knockout Mouse Line	13
Influence of proteolytic cleavage of ENaC’s γ subunit upon Na+ and K+ handling	13
Recent advances in understanding the kidney circadian clock mechanism	13
High baseline ROMK activity in the mouse late distal convoluted and early connecting tubule probably contributes to aldosterone-independent K+ secretion	13
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats	13
Macrophage angiotensin AT2 receptor activation is protective against early phases of LPS-induced acute kidney injury	13
Commensal microbiota regulate aldosterone	13
First Author Spotlight	13
The kidney in health and disease in 2022: Gaps in and opportunities for new knowledge	12
Impaired hemodynamic renal reserve response following recovery from established acute kidney injury and improvement by hydrodynamic isotonic fluid delivery	12

Kir4.1/Kir5.1 of distal convoluted tubule is required for short-term angiotensin-II-induced stimulation of Na-Cl cotransporter	12
Physiology assays in human kidney organoids	12
First Author Spotlight	12
Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging	12
5-hydroxytryptamine 1F receptor loss reduces renal vasculature and prevents lasmiditan-induced recovery following moderate-severe acute kidney injury in mice	12
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension	12
TNIK depletion induces inflammation and apoptosis in injured renal proximal tubule epithelial cells	12
Downloadable Tool for Modeling of Salt, Urea and Water Transport in a Renal Tubule Segment: Application to the DCT	12
Revisiting voltage-coupled H+ secretion in the collecting duct	12
Sex differences in renal acid-base regulation	12
Kidney transplant injury associated with brain death is mediated by TNFα, independently of renal innervation	12
A novel functional role for the classic CNS neurotransmitters, GABA, glycine, and glutamate, in the kidney: potent and opposing regulators of the renal vasculature	12
Injury in nonaged podocytes as an accelerator of glomerular aging	11
Prevention of hypertension-induced renal vascular dysfunction through a p66Shc-targeted mechanism	11
Intersecting transcriptomic landscapes of hypertension and kidney function in African American women	11
A brief harvesting-freezing delay significantly alters the kidney metabolome and leads to false positive and negative results	11
JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice	11
Cystinosin-deficient rats recapitulate the phenotype of nephropathic cystinosis	11
The impact of maternal obesity on polycystic kidney disease progression in a mouse model	11
Sex differences in dietary sodium evoked NCC regulation and blood pressure in male and female Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats	11
Inducible deletion of the prostaglandin EP3 receptor in kidney tubules of male and female mice has no major effect on water homeostasis	11
Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent manner	11
CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes	11
Pendrin regulation is prioritized by anion in high-potassium diets	11
Sex-disaggregated analysis of acute kidney injury in hospitalized children with sickle cell anemia in Uganda	11
Chronic kidney disease amplifies severe kidney injury and mortality in a mouse model of skin arsenical exposure	11
Furin-mediated modification is required for epithelial sodium channel-activating activity of soluble (pro)renin receptor in cultured collecting duct cells	11
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney	10
Promises and challenges of miRNA therapeutics	10
Mitochondrial dysfunction in the pathophysiology of renal diseases	10
Regulation of kidney mitochondrial function by caloric restriction	10
Amiloride lowers plasma TNF and interleukin-6 but not interleukin-17A in patients with hypertension and type 2 diabetes	10
First Author Highlights	10
Proteinuria is accompanied by intratubular complement activation and apical membrane deposition of C3dg and C5b-9 in kidney transplant recipients	10
First Author Highlights	10
Maresin 1 Modulates Renal and Cardiac Lipid Profiles in Hypertensive Rats	10
Male Akita mice develop signs of bladder underactivity independent of NLRP3 as a result of a decrease in neurotransmitter release from efferent neurons	10
Practical notes on popular statistical tests in renal physiology	10
Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress	10
Pretreatment with a novel Toll-like receptor 4 agonist attenuates renal ischemia-reperfusion injury	10
HMGB1 drives T-cell activation in hypertensive males and females	10
Altered renal vascular patterning reduces ischemic kidney injury and limits age-associated vascular loss	10
Exogenous uromodulin and tubular responses in a model of oxalate-induced kidney injury	10
Mechanisms of anti-VEGF therapy-induced kidney injury: current insights and future perspectives in combination with immune checkpoint inhibitors	10
Exogenous pericyte delivery protects the mouse kidney from chronic ischemic injury	10
Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort	10
Influence of carnosine and carnosinase-1 on diabetes-induced afferent arteriole vasodilation: implications for glomerular hemodynamics	10
Bayesian mapping of protein kinases to vasopressin-regulated phosphorylation sites in renal collecting duct	10
The non-steroidal MR antagonist Finerenone reverses Western diet-induced kidney disease by regulating mitochondrial and lipid metabolism and inflammation	9
Creatinine clearance is maintained in a range of wet-bulb globe temperatures and work-rest ratios during simulated occupational heat stress	9
Flow-dependent transport processes 2024: filtration, absorption, secretion	9
Transcription factor HNF1β controls a transcriptional network regulating kidney cell structure and tight junction integrity	9
Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy	9
Adverse functions of neutrophils are regulated by neutrophilic angiotensin-converting enzyme in immune complex-mediated crescentic glomerulonephritis	9
β2-Adrenergic receptor agonists as a treatment for diabetic kidney disease	9
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms’ tumor 1 expression in cultured human podocytes	9
IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage	9
Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury	9
Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity	9
Novel method for kinetic analysis applied to transport by the uniporter OCT2	9
Diffusion tensor MRI is sensitive to fibrotic injury in a mouse model of oxalate-induced chronic kidney disease	8
First Author Highlights	8
Editorial Board	8
Faster bladder filling in rats reduces detrusor overactivity but worsens (i.e., decreases) bladder compliance	8
Assays to enhance metabolic phenotyping in the kidney	8
Role of protease-activated receptor 4 in mouse models of acute and chronic kidney injury	8
Longitudinal intravital microscopy of the mouse kidney: inflammatory responses to abdominal imaging windows	8
Identification of cell division cycle protein 20 in various forms of acute and chronic kidney injury in mice	8
Renal tubular (pro)renin receptor deletion exacerbates kidney injury in db/db mice	8
Metabolomic profiling to identify early urinary biomarkers and metabolic pathway alterations in autosomal dominant polycystic kidney disease	8
Tacrolimus induces fibroblast-to-myofibroblast transition via a TGF-β-dependent mechanism to contribute to renal fibrosis	8
Postoperative acute kidney injury after volatile or intravenous anesthesia: a meta-analysis	8
Kidney functional reserve helps early detection of subclinical chronic kidney disease	8
First Author Spotlight	8
Predicting sex differences in the effects of diuretics in renal epithelial transport during angiotensin II-induced hypertension	8
The degree of aortic occlusion in the setting of trauma alters the extent of acute kidney injury associated with mitochondrial preservation	8
Fasting-induced HMGCS2 expression in the kidney does not contribute to circulating ketones	8
Pathways and parameters of sacral neuromodulation in rats	8
Endothelin-1 signaling in the kidney: recent advances and remaining gaps	8
High dietary salt intake increases urinary NGAL excretion and creatinine clearance in healthy young adults	8

Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program	8
Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation	8
Western diet exacerbates a murine model of Balkan nephropathy	7
Corrigendum for Martínez-Rojas et al., volume 323, 2022, p. F425–F434	7
Cullin 3 mutant causing familial hyperkalemic hypertension lacks normal activity in the kidney	7
Single-cell RNA sequencing and spatial transcriptomics reveal unique subpopulations of infiltrating macrophages and dendritic cells following AKI	7
The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease	7
Endothelial dysfunction in the aging kidney	7
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake	7
The knock-out of paracingulin attenuates hypertension through modulation of kidney ion transport	7
2024 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section	7
Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury	7
Sex differences in circadian regulation of kidney function of the mouse	7
Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice	7
Myo-inositol oxygenase in cadmium-induced kidney injury	7
Expression and distribution of MUC1 in the developing and adult kidney	7
A comparative modeling study of the mitochondrial function of the proximal tubule and thick ascending limb cells in the rat kidney	7
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy	7
The role of Gata3 in renin cell identity	7
KCC3 is not required for the distal convoluted tubule response to reduced dietary potassium intake	7
Transition from acute kidney injury to chronic kidney disease: mechanisms, models, and biomarkers	7
SGLT2 inhibitors: not every drug has the same effect	7
The evolving concepts of KS-WNK1 effect on NCC activity	7
Renal ischemia-reperfusion injury triggers proximal tubular apoptosis and NHE3 dysfunction via p38MAPK/ezrin signaling pathway	7
Corrigendum for McKinzie et al., volume 326, 2024, p. F644–F660	7
Endothelin receptor B is required for the blood pressure-lowering effect of G protein-coupled estrogen receptor 1 in ovariectomized rats	6
The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu)	6
Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes	6
The organelle-tethering protein PDZD8 regulates endolysosomal maturation and TLR9-NF-κB signaling in cisplatin-induced acute kidney injury	6
Podocyte injury at young age causes premature senescence and worsens glomerular aging	6
The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials	6
Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity	6
Role of coagulation in persistent renal ischemia following reperfusion in an animal model	6
Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na+ and K+	6
Intestinal barrier function declines during polycystic kidney disease progression	6
Circadian gene expression in mouse renal proximal tubule	6
Renal calcium and magnesium handling during pregnancy: modeling and analysis	6
Effect of sex chromosome complement versus gonadal hormones on abundance of renal transporters	6
Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect	6
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression	6
Kidney organoid models of polycystic kidney disease: challenges and future directions	6
Anatomic and functional evidence for renal autonomic innervation in normotensive and hypertensive rats	6
First Author Highlights	6
Hepatic and proximal tubule angiotensinogen play distinct roles in kidney dysfunction, glomerular and tubular injury, and fibrosis progression	6
Kidney stone formation in a novel murine model of polycystic kidney disease	6
PLVAP: the new villain in glomerular endothelial cell injury	6
Role of the renal androgen receptor in sex differences in ammonia metabolism	6
Histamine receptors rapidly desensitize without altering nerve-evoked contractions in murine urinary bladder smooth muscle	6
Sex-specific modulation of renal epigenetic and injury markers in aging kidney	6
KV7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure	6
Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damage	6
Electron Paramagnetic Resonance Imaging to Detect Acute Kidney Injury	5
Wilms’ tumor gene 1: lessons from the interface between kidney development and cancer	5
Tips on navigating the first year of graduate school for individuals from historically excluded backgrounds	5
Raising serum uric acid with a uricase inhibitor worsens PKD in rat and mouse models	5
Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice	5
First Author Highlights	5
The endocytic adaptor ARH facilitates potassium conservation by regulating ROMK and BK	5
Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity	5
A new view of macula densa cell protein synthesis	5
Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation and membrane accumulation after EGFR inhibition with erlotinib	5
Modulation of blood pressure by dietary potassium and sodium: sex differences and modeling analysis	5
First Author Spotlight	5
Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease	5
Impact of bedding on Dahl salt-sensitive hypertension and renal damage	5
Guidelines on antibody use in physiology research	5
Endothelial cells: potential novel regulators of renal inflammation	5
The FSGS protein actinin-4 interacts with NKCC2 to regulate thick ascending limb NaCl reabsorption	5
Renal macro- and microcirculatory perturbations in acute kidney injury and chronic kidney disease associated with heart failure and cardiac surgery	5
Angiotensin (1–7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats	5
Role of the SLC22A17/lipocalin-2 receptor in renal endocytosis of proteins/metalloproteins: a focus on iron- and cadmium-binding proteins	5
Proximal tubule pannexin 1 contributes to mitochondrial dysfunction and cell death during acute kidney injury	5
Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria	5
Generation of Atp6v1g3-Cre mice for investigation of intercalated cells and the collecting duct	5
Autophagy and mitophagy: physiological implications in kidney inflammation and diseases	5
Amiloride evokes significant natriuresis and weight loss in kidney transplant recipients with and without albuminuria	5
Nicorandil protects podocytes via modulation of antioxidative capacity in acute puromycin aminonucleoside-induced nephrosis in rats	5
The Janus view: dual roles for hypoxia-inducible factor in renal repair after acute kidney injury	5
ACE2 deficiency protects against heme protein-induced acute kidney injury	4
Sex differences in the adrenal circadian clock: a role for BMAL1 in the regulation of urinary aldosterone excretion and renal electrolyte balance in mice	4
A novel VCP modulator KUS121 exerts renoprotective effects in ischemia-reperfusion injury with retaining ATP and restoring ERAD-processing capacity	4
First Author Spotlight	4
The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain	4
ASK1 limits kidney glucose reabsorption, growth, and mid-late proximal tubule KIM-1 induction when diabetes and Western diet are combined with SGLT2 inhibition	4
Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model	4
Corrigendum for Chen et al., volume 314, 2018, p. F572–F583	4
Pharmacological inhibition of the mixed lineage leukemia 1-menin interaction aggravates acute kidney injury induced by folic acid and ischemia-reperfusion in mice	4
Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1	4
Mitochondria-derived reactive oxygen species contribute to synergistic interaction of diabetes and hypertension in causing chronic kidney injury	4
First Author Highlights	4
Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease	4
Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions	4
Arginine vasopressin regulates the renal Na+-Cl– and Na+-K+-Cl– cotransporters through with-no-lysine kinase 4 and inhibitor 1 phosphorylation	4
Fasting mimicking diet in diabetic mice partially preserves glomerular endothelial glycocalyx coverage, without changing the diabetic metabolic environment	4
Neuropilin 1 promotes unilateral ureteral obstruction-induced renal fibrosis via RACK1 in renal tubular epithelial cells	4