American Journal of Physiology-Renal Physiology

Article	Citations
Mitochondrial dysfunction and the AKI-to-CKD transition	108
The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction	60
Effects of SGLT2 inhibitor and dietary NaCl on glomerular hemodynamics assessed by micropuncture in diabetic rats	49
Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model	48
A plasma creatinine- and urea-based equation to estimate glomerular filtration rate in rats	45
Skeletal myopathy in CKD: a comparison of adenine-induced nephropathy and 5/6 nephrectomy models in mice	40
Exercise intolerance in kidney diseases: physiological contributors and therapeutic strategies	36
Class IIa HDAC inhibitor TMP195 alleviates lipopolysaccharide-induced acute kidney injury	35
Salt-sensitive hypertension in chronic kidney disease: distal tubular mechanisms	32
Distal convoluted tubule sexual dimorphism revealed by advanced 3D imaging	32
Sex differences in renal mitochondrial function: a hormone-gous opportunity for research	31
Regulated cell death in cisplatin-induced AKI: relevance of myo-inositol metabolism	30
Critical role of the mineralocorticoid receptor in aldosterone-dependent and aldosterone-independent regulation of ENaC in the distal nephron	30
The complicated role of mitochondria in the podocyte	30
Nrf2 mediates hypoxia-inducible HIF1α activation in kidney tubular epithelial cells	29
Cerebral blood flow regulation in end-stage kidney disease	29
SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na+ transport in Dahl SS rats	28
Adaptive changes in single-nephron GFR, tubular morphology, and transport in a pregnant rat nephron: modeling and analysis	27
Histone deacetylase 6 inhibition mitigates renal fibrosis by suppressing TGF-β and EGFR signaling pathways in obstructive nephropathy	27
METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation	25
Expression of lactate dehydrogenase A and B isoforms in the mouse kidney	25
Fasting-induced HMGCS2 expression in the kidney does not contribute to circulating ketones	24
HIF-1α is transcriptionally regulated by NF-κB in acute kidney injury	24
Novel Fanconi renotubular syndromes provide insights in proximal tubule pathophysiology	24
Protective effect of d-alanine against acute kidney injury	24

Disparate roles of retinoid acid signaling molecules in kidney disease	23
Inhaled silica nanoparticles cause chronic kidney disease in rats	23
Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching	23
Sacubitril/valsartan treatment has differential effects in modulating diabetic kidney disease in db/db mice and KKAy mice compared with valsartan treatment	22
Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome	22
Cubilin-, megalin-, and Dab2-dependent transcription revealed by CRISPR/Cas9 knockout in kidney proximal tubule cells	22
Regulation of mitochondrial dynamics and energetics in the diabetic renal proximal tubule by the β2-adrenergic receptor agonist formoterol	22
Endothelial cells: potential novel regulators of renal inflammation	21
Localization and regulation of claudin-14 in experimental models of hypercalcemia	21
Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats	20
Rapid development of vasopressin resistance in dietary K+ deficiency	20
Sex differences in circadian regulation of kidney function of the mouse	20
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression	20
Overexpression of TGF-β1 induces renal fibrosis and accelerates the decline in kidney function in polycystic kidney disease	20
Angiotensin type 2 receptor activation limits kidney injury during the early phase and induces Treg cells during the late phase of renal ischemia	19
Roles of WNK4 and SPAK in K+-mediated dephosphorylation of the NaCl cotransporter	19
Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy	19
Magnesium reabsorption in the kidney	18
Aristolochic acid-induced nephropathy is attenuated in mice lacking the neutral amino acid transporter B0AT1 (Slc6a19)	18
Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease	18
CD4+ T cells cause renal and placental mitochondrial oxidative stress as mechanisms of hypertension in response to placental ischemia	18
Alkali supplementation as a therapeutic in chronic kidney disease: what mediates protection?	18
Synaptopodin deficiency exacerbates kidney disease in a mouse model of Alport syndrome	17
SGLT2 inhibitor and loop diuretic induce different vasopressin and fluid homeostatic responses in nondiabetic rats	17
Soluble (pro)renin receptor promotes the fibrotic response in renal proximal tubule epithelial cells in vitro via the Akt/β-catenin/Snail signaling pathway	17
Role of the polycystins as mechanosensors of extracellular stiffness	17
Pathomorphological sequence of nephron loss in diabetic nephropathy	17
Fibroblast growth factor 23 leads to endolysosomal routing of the renal phosphate cotransporters NaPi-IIa and NaPi-IIc in vivo	17
Involvement of the CDKL5-SOX9 signaling axis in rhabdomyolysis-associated acute kidney injury	17
The kidney protects against sepsis by producing systemic uromodulin	17
Renal lymphatic vessel dynamics	17
T cell-derived extracellular vesicles are elevated in essential HTN	17
Localization of angiotensin II type 1 receptor gene expression in rodent and human kidneys	17
A naturally occurring FXR agonist, alisol B 23-acetate, protects against renal ischemia-reperfusion injury	17
Increased SGK1 activity potentiates mineralocorticoid/NaCl-induced kidney injury	17
RNA-Seq profiling of microdissected glomeruli identifies potential biomarkers for human IgA nephropathy	17
Experimental nephrotic syndrome leads to proteolytic activation of the epithelial Na+ channel in the mouse kidney	17
Deletion of renal Nedd4-2 abolishes the effect of high sodium intake (HS) on Kir4.1, ENaC, and NCC and causes hypokalemia during high HS	16
Blockade of STAT3 signaling alleviates the progression of acute kidney injury to chronic kidney disease through antiapoptosis	16
Chemokine CCL2 from proximal tubular epithelial cells contributes to sepsis-induced acute kidney injury	16
Cleavage state of γENaC in mouse and rat kidneys	16
A new view of macula densa cell microanatomy	16
Beyond the tubule: pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease	16
(Pro)renin receptor decoy peptide PRO20 protects against adriamycin-induced nephropathy by targeting the intrarenal renin-angiotensin system	16
Time-dependent progression of neurogenic lower urinary tract dysfunction after spinal cord injury in the mouse model	16
Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction	16
Differential localization patterns of claudin 10, 16, and 19 in human, mouse, and rat renal tubular epithelia	16
Physiology assays in human kidney organoids	16
AMP-activated protein kinase contributes to cisplatin-induced renal epithelial cell apoptosis and acute kidney injury	16
Expression and function of human ribonuclease 4 in the kidney and urinary tract	16

Lipotoxicity dysregulates the immunoproteasome in podocytes and kidneys in type 2 diabetes	16
Bayesian identification of candidate transcription factors for the regulation of Aqp2 gene expression	15
Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury	15
Silencing of the lncRNA TUG1 attenuates the epithelial-mesenchymal transition of renal tubular epithelial cells by sponging miR-141-3p via regulating β-catenin	15
Landscape of GPCR expression along the mouse nephron	15
Nicotine, smoking, podocytes, and diabetic nephropathy	15
Mitochondria as mediators of systemic inflammation and organ cross talk in acute kidney injury	15
Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease	15
L-WNK1 is required for BK channel activation in intercalated cells	15
Autoimmunity to urothelial antigen causes bladder inflammation, pelvic pain, and voiding dysfunction: a novel animal model for Hunner-type interstitial cystitis	15
Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction	14
Antibiotic-induced microbiome depletion alters renal glucose metabolism and exacerbates renal injury after ischemia-reperfusion injury in mice	14
NMR-based serum and urine metabolomic profile reveals suppression of mitochondrial pathways in experimental sepsis-associated acute kidney injury	14
Inward Ca2+ current through the polycystin-2-dependent channels of renal primary cilia	14
Calcineurin inhibitors: a double-edged sword	14
Effects of long-term intradialytic oral nutrition and exercise on muscle protein homeostasis and markers of mitochondrial content in patients on hemodialysis	14
Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease	14
The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain	14
Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury	14
Zebrafish (Danio rerio) larva as an in vivo vertebrate model to study renal function	14
High dietary salt intake increases urinary NGAL excretion and creatinine clearance in healthy young adults	14
Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression	14
PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells	13
Circadian variation in renal blood flow and kidney function in healthy volunteers monitored with noninvasive magnetic resonance imaging	13
Protein kinase A catalytic-α and catalytic-β proteins have nonredundant regulatory functions	13
Non-purine selective xanthine oxidase inhibitor ameliorates glomerular endothelial injury in InsAkita diabetic mice	13
High baseline ROMK activity in the mouse late distal convoluted and early connecting tubule probably contributes to aldosterone-independent K+ secretion	13
Porcine models of acute kidney injury	13
Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance	13
Role of the renal androgen receptor in sex differences in ammonia metabolism	13
Deletion of Kir5.1 abolishes the effect of high Na+ intake on Kir4.1 and Na+-Cl− cotransporter	13
WNK4 kinase: from structure to physiology	13
NaCl cotransporter activity and Mg2+handling by the distal convoluted tubule	13
Inhibition of 15-PGDH prevents ischemic renal injury by the PGE2/EP4signaling pathway mediating vasodilation, increased renal blood flow, and increased adenosine/A2Are	12
Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury	12
Podocyte endowment and the impact of adult body size on kidney health	12
Myo-inositol oxygenase overexpression exacerbates cadmium-induced kidney injury via oxidant stress and necroptosis	12
Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology	12
Urinary DPP4 correlates with renal dysfunction, and DPP4 inhibition protects against the reduction in megalin and podocin expression in experimental CKD	12
IFT88 deficiency in proximal tubular cells exaggerates cisplatin-induced injury by suppressing autophagy	12
TAZ is important for maintenance of the integrity of podocytes	12
Lasmiditan promotes recovery from acute kidney injury through induction of mitochondrial biogenesis	11
Pendrin-null mice develop severe hypokalemia following dietary Na+ and K+ restriction: role of ENaC	11
FGF21 prevents low-protein diet-induced renal inflammation in aged mice	11
Single-cell mRNA profiling reveals changes in solute carrier expression and suggests a metabolic switch during zebrafish pronephros development	11
Renal claudin-14 expression is not required for regulating Mg2+ balance in mice	11
Heat acclimation ameliorated heat stress-induced acute kidney injury and prevented changes in kidney macrophages and fibrosis	11
Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction	11
Transient receptor potential cation channel 6 contributes to kidney injury induced by diabetes and hypertension	11
Aldosterone sensitivity: an opportunity to explore the pathogenesis of hypertension	11
Proteinuria is accompanied by intratubular complement activation and apical membrane deposition of C3dg and C5b-9 in kidney transplant recipients	11
A call to action to evaluate renal functional reserve in patients with COVID-19	11
KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury	11
A mathematical model of the rat kidney. IV. Whole kidney response to hyperkalemia	11
Klotho overexpression protects against renal aging along with suppression of transforming growth factor-β1 signaling pathways	10
Indirect podocyte injury manifested in a partial podocytectomy mouse model	10
Intrarenal modulation of NF-κB activity attenuates cardiac injury in a swine model of CKD: a renal-cardio axis	10
Sex differences in renal ammonia metabolism	10
Salt sensitivity of volume and blood pressure in a mouse with globally reduced ENaC γ-subunit expression	10
DPP4 inhibition mitigates ANG II-mediated kidney immune activation and injury in male mice	10
Solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney	10
Autophagy and mitophagy: physiological implications in kidney inflammation and diseases	10
Development of a quantitative systems pharmacology model of chronic kidney disease: metabolic bone disorder	10
Effect of forkhead box O1 in renal tubular epithelial cells on endotoxin-induced acute kidney injury	10
LncRNA GAS5 protects against TGF-β-induced renal fibrosis via the Smad3/miRNA-142-5p axis	10
A uropathogenic E. coli UTI89 model of prostatic inflammation and collagen accumulation for use in studying aberrant collagen production in the prostate	10
N-methyl-d-aspartate receptor hyperfunction contributes to d-serine-mediated renal insufficiency	10
Global REACH 2018: renal oxygen delivery is maintained during early acclimatization to 4,330 m	9
VEGFR3 tyrosine kinase inhibition aggravates cisplatin nephrotoxicity	9
High salt intake induces collecting duct HDAC1-dependent NO signaling	9
A new view of macula densa cell protein synthesis	9
An in vivo protein landscape of the mouse DCT during high dietary K+ or low dietary Na+ intake	9
Image analysis techniques to map pyramids, pyramid structure, glomerular distribution, and pathology in the intact human kidney from 3-D MRI	9
Role of the SLC22A17/lipocalin-2 receptor in renal endocytosis of proteins/metalloproteins: a focus on iron- and cadmium-binding proteins	9
Deletion of renal Nedd4-2 abolishes the effect of high K+ intake on Kir4.1/Kir5.1 and NCC activity in the distal convoluted tubule	9
Psychotropic drugs upregulate aquaporin-2 via vasopressin-2 receptor/cAMP/protein kinase A signaling in inner medullary collecting duct cells	9
Dietary salt modifies the blood pressure response to renin-angiotensin inhibition in experimental chronic kidney disease	9
Decreased tubuloglomerular feedback response in high-fat diet-induced obesity	9
IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage	9
CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder	9

SGLT2 inhibitors, hemodynamics, and kidney protection	9
Mapping nephron mass in vivo using positron emission tomography	9
Transcriptomic signatures of exacerbated progression in leptospirosis subclinical chronic kidney disease with secondary nephrotoxic injury	9
Single cell versus single nucleus: transcriptome differences in the murine kidney after ischemia-reperfusion injury	9
High-calorie diet results in reversible obesity-related glomerulopathy in adult zebrafish regardless of dietary fat	9
Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice	9
Caspase-3-dependent peritubular capillary dysfunction is pivotal for the transition from acute to chronic kidney disease after acute ischemia-reperfusion injury	9
Questioning the renoprotective role of L-type calcium channel blockers in chronic kidney disease using physiological modeling	8
Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury	8
The hypoxia-inducible factor-α prolyl hydroxylase inhibitor FG4592 ameliorates renal fibrosis by inducing the H3K9 demethylase JMJD1A	8
Promises and challenges of miRNA therapeutics	8
Role of Ano1 Ca2+-activated Cl− channels in generating urethral tone	8
Cardiac effects of renal ischemia	8
Macrophage angiotensin AT2 receptor activation is protective against early phases of LPS-induced acute kidney injury	8
Navigating the kidney organoid: insights into assessment and enhancement of nephron function	8
Studies of ultrastructure, gene expression, and marker analysis reveal that mouse bladder PDGFRA+ interstitial cells are fibroblasts	8
15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction	8
The Indiana O’Brien Center for Advanced Renal Microscopic Analysis	8
TRPV4 expression in the renal tubule is necessary for maintaining whole body K+ homeostasis	8
The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology	8
Angiotensin II biphasically regulates cell differentiation in human iPSC-derived kidney organoids	8
Effects of a mitochondrial-targeted ubiquinol on vascular function and exercise capacity in chronic kidney disease: a randomized controlled pilot study	8
Specialized proresolution mediators in the bladder: annexin-A1 normalizes inflammation and bladder dysfunction during bladder outlet obstruction	8
Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion	8
Splenocyte transfer from hypertensive donors eliminates premenopausal female protection from ANG II-induced hypertension	8
Regulation of kidney mitochondrial function by caloric restriction	8
Cross talk between lysine methyltransferase Smyd2 and TGF-β-Smad3 signaling promotes renal fibrosis in autosomal dominant polycystic kidney disease	8
Semaporin3A inhibitor ameliorates renal fibrosis through the regulation of JNK signaling	8
Proximal tubule cyclophilin D mediates kidney fibrogenesis in obstructive nephropathy	7
The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease	7
Effects of caloric restriction and aerobic exercise on circulating cell-free mitochondrial DNA in patients with moderate to severe chronic kidney disease	7
Connexin43 is differentially distributed within renal vasculature and mediates profibrotic differentiation in medullary fibroblasts	7
Sprr2f protects against renal injury by decreasing the level of reactive oxygen species in female mice	7
Hypoxia-inducible factor protects against acute kidney injury via the Wnt/β-catenin signaling pathway	7
Functional characterization of ion channels expressed in kidney organoids derived from human induced pluripotent stem cells	7
Data resource: vasopressin-regulated protein phosphorylation sites in the collecting duct	7
Afferent renal innervation in anti-Thy1.1 nephritis in rats	7
Pharmacological inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury	7
Role of the CX3CL1-CX3CR1 axis in renal disease	7
Role of soluble guanylyl cyclase in renal afferent and efferent arterioles	7
Folic acid-mediated fibrosis is driven by C5a receptor 1-mediated activation of kidney myeloid cells	7
Angiotensin (1–7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats	7
Actin-related protein 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway	7
The oxygen cascade in patients treated with hemodialysis and native high-altitude dwellers: lessons from extreme physiology to benefit patients with end-stage renal disease	7
Combination treatment with tenapanor and sevelamer synergistically reduces urinary phosphorus excretion in rats	7
Isoprostanes evoke contraction of the murine and human detrusor muscle via activation of the thromboxane prostanoid TP receptor and Rho kinase	7
ROMK channels are inhibited in the aldosterone-sensitive distal nephron of renal tubule Nedd4-2-deficient mice	7
The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu)	7
Receptor-associated protein impairs ligand binding to megalin and megalin-dependent endocytic flux in proximal tubule cells	7
Guidelines for microbiome studies in renal physiology	7
Less sodium, more potassium, or both: population-wide strategies to prevent hypertension	7
Store-operated Ca2+ entry inhibition ameliorates high glucose and ANG II-induced podocyte apoptosis and mitochondrial damage	7
A mini-review of pharmacological strategies used to ameliorate polyuria associated with X-linked nephrogenic diabetes insipidus	7
Influence of carnosine and carnosinase-1 on diabetes-induced afferent arteriole vasodilation: implications for glomerular hemodynamics	7
Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect	7
Role of miR-379 in high-fat diet-induced kidney injury and dysfunction	7
Kidney resident macrophages in the rat have minimal turnover and replacement by blood monocytes	6
Tacrolimus induces fibroblast-to-myofibroblast transition via a TGF-β-dependent mechanism to contribute to renal fibrosis	6
Bladder infection with uropathogenic Escherichia coli increases the excitability of afferent neurons	6
Kidney-targeted irradiation triggers renal ischemic preconditioning in mice	6
Acute kidney injury biomarkers and hydration assessments following prolonged mild hypohydration in healthy young adults	6
Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes	6
Coupling of renal sodium and calcium transport: a modeling analysis of transporter inhibition and sex differences	6
The transcription factor Foxi1 promotes expression of V-ATPase and Gpr116 in M-1 cells	6
B2 cells contribute to hypertension and natural killer cell activation possibly via AT1-AA in response to placental ischemia	6
Impact of bedding on Dahl salt-sensitive hypertension and renal damage	6
A new mechanism for the sex differences in angiotensin II-induced hypertension: the role of macula densa NOS1β-mediated tubuloglomerular feedback	6
Thick ascending limb claudins are altered to increase calciuria and magnesiuria in metabolic acidosis	6
Myo-inositol oxygenase in cadmium-induced kidney injury	6
Metabolic acidosis regulates RGS16 and G protein signaling in osteoblasts	6
C1 inhibitor mitigates peritoneal injury in zymosan-induced peritonitis	6
Renal-specific loss of ferroportin disrupts iron homeostasis and attenuates recovery from acute kidney injury	6
Acid-base effects of combined renal deletion of NBCe1-A and NBCe1-B	6
Renal NG2-expressing cells have a macrophage-like phenotype and facilitate renal recovery after ischemic injury	6
Renal cell markers: lighthouses for managing renal diseases	6
Practical notes on popular statistical tests in renal physiology	6
Consensus draft of the native mouse podocyte-ome	6
Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity	6
Pendrin regulation is prioritized by anion in high-potassium diets	6
Sex-specific epigenetic programming in renal fibrosis and inflammation	6
Cullin 3 mutant causing familial hyperkalemic hypertension lacks normal activity in the kidney	6
Formation of the glomerular microvasculature is regulated by VEGFR-3	6
Role of (pro)renin receptor in cyclosporin A-induced nephropathy	6
Soluble α-klotho anchors TRPV5 to the distal tubular cell membrane independent of FGFR1 by binding TRPV5 and galectin-1 simultaneously	6
Overview of acute kidney manifestations and management of patients with COVID-19	6
Restoration of afferent arteriolar autoregulatory behavior in ischemia-reperfusion injury in rat kidneys	6
Mapping kidney tubule diameter ex vivo by diffusion MRI	6
Activation of the RAS contributes to peritoneal fibrosis via dysregulation of low-density lipoprotein receptor	6
Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases	6
SLC41A1 knockout mice display normal magnesium homeostasis	6
The potential role of Na-K-ATPase and its signaling in the development of anemia in chronic kidney disease	6
Predicting oxygen tension along the ureter	6
Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarker in autosomal dominant tubulointerstitial kidney disease	5
Endothelial mechanical stretch regulates the immunological synapse interface of renal endothelial cells in a sex-dependent manner	5
Chronic treatment with IL-25 increases renal M2 macrophages and reduces renal injury in obese Dahl salt-sensitive rats during the prepubescent stage	5