OOIR: Observatory of International Research

Papers

(The TQCC of IUBMB Life is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Variability in the levels of exosomal miRNAs among human subjects could be explained by differential interactions of exosomes with the endothelium	68
The heparan sulphate proteoglycan Syndecan‐1 (CD138) regulates tumour progression in a 3D model of ductal carcinoma in situ of the breast	61
Anti‐inflammatory effects of sodium‐glucose cotransporter‐2 inhibitors in COVID‐19	45
Retraction	43
Retraction	43
Simultaneous blockade of the CD73/EGFR axis inhibits tumor growth	33
Integrated multi‐omics and machine learning reveal a gefitinib resistance signature for prognosis and treatment response in lung adenocarcinoma	32
Cytokeratin 13 promotes radiotherapy sensitivity of nasopharyngeal carcinoma by downregulating the MEK/ERK pathway	31
Issue Information	30
Mammalian iron sulfur cluster biogenesis and human diseases	30
The history of IUBMB Life (1980–2020)	29
Issue Information	29
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Inorganic phosphate‐induced cytotoxicity	28
Nuclear and cytoplasmic lncRNAs in root tips of the model legume Medicago truncatula under control and submergence	27
Issue Information	27
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Issue Highlights	24
Addressing the impact of high glucose microenvironment on the immunosuppressive characteristics of human mesenchymal stem cells	23
Bromodomain‐containing protein 9 is a prognostic biomarker associated with immune infiltrates and promotes tumor malignancy through activating notch signaling pathway in negative HIF‐2α cle	23
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Mitochondrial iron and calcium homeostasis in Friedreich ataxia	23
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Oral administration of herbal oligonucleotide drug JGL‐sRNA‐h7 ameliorates hyperglycemia in db/db mice and beagle dogs	20
Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow	20
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Issue Information	20
A hybrid approach to assess the structural impact of long noncoding RNA mutations uncovers key NEAT1 interactions in colorectal cancer	19
Comparative analysis of the potential of the secretomes of cardiac resident stromal cells and fibroblasts	19
PD‐1/PD‐L1 blockade: Prospectives for immunotherapy in cancer and autoimmunity	19
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Lobeline: A multifunctional alkaloid modulates cholinergic and glutamatergic activities	18
Maternal Socs3 knockdown attenuates postnatal obesity caused by an early life environment of maternal obesity and intrauterine overnutrition in progeny mice	17
A standardised nomenclature for long non‐coding RNAs	17
Activation of E3 ubiquitin ligase WWP2 by non‐receptor tyrosine kinase ACK1	16
Mitochondrial protein and organelle quality control—Lessons from budding yeast	16
β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts	16
LncRNA RP11‐301G19.1 is required for the maintenance of vascular smooth muscle cell contractile phenotype via sponging miR‐17‐5P/ATOH8 axis	16
Impact of supplementation with vitamins B₆, B₁₂, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A sys	15
Issue Information	15
miR‐543 in human mesenchymal stem cell–derived exosomes promotes cardiac microvascular endothelial cell angiogenesis after myocardial infarction through COL4A1	15
Diminished substrate‐mediated cardiac mitochondrial respiration and elevated autophagy in adult male offspring of gestational diabetic rats	14
Mimicking human riboflavin responsive neuromuscular disorders by silencing flad‐1 gene in C. elegans: Alteration of vitamin transport and cholinergic transmission	14
The roles of proteases in prostate cancer	14
The CD40/CD40 ligand dyad and its downstream effector molecule ISG54 in relating acute neuroinflammation with persistent, progressive demyelination	14
Serum/glucocorticoid‐regulated kinase 1‐targeted transient receptor potential oxalate subtype 1 regulates bladder smooth muscle cell proliferation due to bladder outlet obstruction in mice via activat	14
Thiourea derivatives inhibit key diabetes‐associated enzymes and advanced glycation end‐product formation as a treatment for diabetes mellitus	13
Resistance to prostate cancer treatments	13
Amyloid‐β40 E22K fibril in familial Alzheimer's disease is more thermostable and susceptible to seeding	13
RNPS1 functions as an oncogenic splicing factor in cervical cancer cells	13
iTRAQ‐based proteomic analysis of 17β‐Estradiol‐induced anti‐proliferation and apoptosis in mouse thymic epithelial cells by disturbing ribosomal biogenesis	12
Fingolimod (FTY720), an FDA‐approved sphingosine 1‐phosphate (S1P) receptor agonist, restores endothelial hyperpermeability in cellular and animal models of dengue vir	12
Decreased differentiation capacity and altered expression of extracellular matrix components in irradiation‐mediated senescent human breast adipose‐derived stem cells	12
Bencaosome [16:0 Lyso PA+XLGB28‐sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice	11
m⁶A transferase KIAA1429‐stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1	11
Autophagy and cancer metabolism—The two‐way interplay	11
Central nervous system cholesterol metabolism in health and disease	11
Gastrointestinal tissue as a “new” target of pollution exposure	11
LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study	11
The role of the proteasome in mitochondrial protein quality control	10
SHP2: The protein tyrosine phosphatase involved in chronic pulmonary inflammation and fibrosis	10
Extracellular adenosine oppositely regulates the purinome machinery in glioblastoma and mesenchymal stem cells	10
Greater TIMP‐1 protein levels and neointimal formation represent sex‐dependent cellular events limiting aortic vessel expansion in female rats	10
p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation	10
Correction to “Association of nonalcoholic fatty liver disease with a single nucleotide polymorphism on the gene encoding leptin receptor”	10
Irisin alleviates the pyroptosis of β cells in T2DM by inhibiting NLRP3 inflammasome through regulating miR‐19b‐3p/SOCS3/STAT3 axis mediated auto	10
Microtubule depolymerization induces ferroptosis in neuroblastoma cells	10
Mesenchymal stem cells (MSCs) and MSC‐derived exosomes in animal models of central nervous system diseases: Targeting the NLRP3 inflammasome	10
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non‐Small cell lung cancer and inhibit tumor progression	10
Erratum	10
SNHG14 promotes triple‐negative breast cancer cell proliferation, invasion, and chemoresistance by regulating the ERK/MAPK signaling pathway	10
Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway	9
The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses	9

Tinagl1 restores tamoxifen sensitivity and blocks fibronectin‐induced EMT by simultaneously blocking the EGFR and β1‐integrin/FAK signaling pathways in tamoxifen‐resis	9
EXPRESSION OF CONCERN: Laccase Treatment Impairs Bisphenol A‐Induced Cancer Cell Proliferation Affecting Estrogen Receptor α‐Dependent Rapid Signals	9
The latest achievements in biochemistry, biophysics and biotechnology—50 years of history of the Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, Poland	9
Human disease‐causing missense genetic variants are enriched in the evolutionarily ancient domains of the cytosolic aminoacyl‐tRNA synthetase proteins	9
Erratum to Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta‐analysis	9
Deciphering the senescence‐based tumoral heterogeneity and characteristics in pancreatic cancer: Results from parallel bulk and single‐cell transcriptome data	9
Issue Highlights	8
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Issue Highlights	8
Cover Image	8
Issue Information	8
YTHDF3 rs7464 A > G polymorphism increases Chinese neuroblastoma risk: A multiple‐center case–control study	8
Combined doxorubicin and arctigenin treatment induce cell cycle arrest‐associated cell death by promoting doxorubicin uptake in doxorubicin‐resistant breast cancer cells	7
Cyclin‐dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway	7
Issue Information	7
N1‐methyladenosine profiling of long non‐coding RNA in colorectal cancer	7
Herbal inhibitors of SARS‐CoV‐2 M^pro effectively ameliorate acute lung injury in mice	7
LncRTPred: Predicting RNA–RNA mode of interaction mediated by lncRNA	7
Mast cells: Therapeutic targets for COVID‐19 and beyond	7
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Low expression of PCK2 in breast tumors contributes to better prognosis by inducing senescence of cancer cells	6
Exosomes derived from Baicalin‐pretreated bone mesenchymal stem cells improve Th17/Treg imbalance after hepatic ischemia–reperfusion via FGF21 and the JAK2/STAT3<	6
Involvement of sialoglycans in SARS‐COV‐2 infection: Opportunities and challenges for glyco‐based inhibitors	6
Thrombospondins in human aortic aneurysms	6
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Condition‐dependent structural collapse in the intrinsically disordered N‐terminal domain of prion protein	6
Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross‐talk with p53 to activate p21	6
Issue Highlights	6
Recent advances in BCRP‐induced breast cancer resistance treatment with marine‐based natural products	6
ENSMUST00000147869 regulates proliferation and fibrosis of mesangial cells in diabetic nephropathy by interacting with Hspa9	6
Functional TET2 gene polymorphisms increase the risk of neuroblastoma in Chinese children	6
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Humanized disulfide‐stabilized diabody against fibroblast growth factor‐2 inhibits PD‐L1 expression and epithelial‐mesenchymal transition in hepatoma cells through STAT3	6
Transcriptional regulatory networks of the proteasome in mammalian systems	6
MST4 as a novel therapeutic target for autophagy and radiosensitivity in gastric cancer	6
Issue Information	6
Endogenous dipeptide‐carnosine supplementation ameliorates hypobaric hypoxia‐induced skeletal muscle loss via attenuating endoplasmic reticulum stress response and maintaining proteostasis	5
Issue Highlights	5
Arabidopsis thaliana possesses two novel ELL associated factor homologs	5
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miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response	5
Stem cell genes in atheromatosis: The role of Klotho, HIF1α, OCT4, and BMP4	5
Issue Information	5
Issue Information	5
Issue Highlights	5
Issue Information	5
Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer	5
Reflections on the 50‐year history of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB)	5
Cover Image	5
Screening and experimental validation of diagnostic gene in ulcerative colitis with anti‐TNF‐α therapy	5
Placenta‐specific protein 1 promotes cell proliferation via the AKT/GSK‐3β/cyclin D1 signaling pathway in gastric cancer	5
William “Bill” Joseph Whelan, D.Sc., FRS November 14, 1924 to June 5, 2021	5
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Issue Information	5
Issue Information	5
Genetic tools to dissect functions of long noncoding RNAs	5