OOIR: Observatory of International Research

Papers

(The TQCC of IUBMB Life is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-10-01 to 2024-10-01.)

Article	Citations
Toll‐like receptors in neuroinflammation, neurodegeneration, and alcohol‐induced brain damage	59
Glucose‐regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders	57
N⁶‐methyladenosine modification of circular RNA circ‐ARL3 facilitates Hepatitis B virus‐associated hepatocellular carcinoma via sponging miR‐1305	51
Toll‐like receptors (TLRs) in cancer; with an extensive focus on TLR agonists and antagonists	51
M2 macrophage‐derived exosomal miR‐25‐3p improves high glucose‐induced podocytes injury through activation autophagy via inhibiting DUSP1 expression	45
m⁶A transferase KIAA1429‐stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1	43
Xanthohumol from Hop: Hope for cancer prevention and treatment	40
Iron overload‐induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study	38
Structure, catalysis, and inhibition mechanism of prenyltransferase	37
The apoptosis‐inducing factor family: Moonlighting proteins in the crosstalk between mitochondria and nuclei	35
m6A methyltransferase Wilms' tumor 1‐associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual‐specifici	34
One‐year mortality and consequences of COVID‐19 in cancer patients: A cohort study	33
Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role	32
Endoplasmic reticulum stress and NF‐kB activation in SARS‐CoV‐2 infected cells and their response to antiviral therapy	31
Circulating exosomal microRNAs as emerging non‐invasive clinical biomarkers in heart failure: Mega bio‐roles of a nano bio‐particle	30
Identification of mutation resistance coldspots for targeting the SARS‐CoV2 main protease	30
The immunomodulatory effects of mesenchymal stromal cell‐based therapy in human and animal models of systemic lupus erythematosus	30
Mitochondrial transport and metabolism of the vitamin B‐derived cofactors thiamine pyrophosphate, coenzyme A,FADandNAD⁺, and related diseases: A review	30
LncRNA RAD51‐AS1/miR‐29b/c‐3p/NDRG2 crosstalk repressed proliferation, invasion and glycolysis of colorectal cancer	30
T‐cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer	29
FOXO transcription factors in antioxidant defense	29
Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma	28
Mitophagy in aging and longevity	28
Hormesis: Transforming disciplines that rely on the dose response	27
Expression levels of miR‐27a, miR‐329, ABCA1, and ABCG1 genes in peripheral blood mononuclear cells and their correlation with serum levels of	27

Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high‐fat diet fed mice	26
Long non‐coding RNAs as potential biomarkers in the prognosis and diagnosis of lung cancer: A review and target analysis	26
Exosomes derived from T regulatory cells relieve inflammatory bowel disease by transferring miR‐195a‐3p	26
Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression	26
ATF4‐modified serum exosomes derived from osteoarthritic mice inhibit osteoarthritis by inducing autophagy	26
Oxidized low‐density lipoprotein accelerates the injury of endothelial cells viacirc‐USP36/miR‐98‐5p/VCAM1axis	24
Naringin‐generated ROS promotes mitochondria‐mediated apoptosis in Candida albicans	24
Iron accumulation regulates osteoblast apoptosis through lncRNAXIST/miR‐758‐3p/caspase 3 axis leading to osteoporosis	24
Circ_0072088 promotes progression of hepatocellular carcinoma by activating JAK2/STAT3 signaling pathway via miR‐375	23
CPEB1 enhances erastin‐induced ferroptosis in gastric cancer cells by suppressing twist1 expression	23
Combined effect of chrysin and apigenin on inhibiting the development and progression of colorectal cancer by suppressing the activity of P38‐MAPK/AKT pathway	23
Targeting amino acid metabolism of Mycobacterium tuberculosis for developing inhibitors to curtail its survival	22
Mitochondria and nucleus cross‐talk: Signaling in metabolism, apoptosis, and differentiation, and function in cancer	22
MiR‐770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway	21
Shedding more light on the role of Midkine in hepatocellular carcinoma: New perspectives on diagnosis and therapy	21
The potential therapeutic effects of curcumin on pregnancy complications: Novel insights into reproductive medicine	21
The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: Possibilities for therapeutic interventions either as single agents or in combination with conventional therapies	20
Mitochondrial–nuclear p53 trafficking controls neuronal susceptibility in stroke	20
Desaturases: Structural and mechanistic insights into the biosynthesis of unsaturated fatty acids	20
Gastrointestinal tissue as a “new” target of pollution exposure	20
Homeostatic control of redox status and health	20
miR‐543 in human mesenchymal stem cell–derived exosomes promotes cardiac microvascular endothelial cell angiogenesis after myocardial infarction through COL4A1	20
N1‐methyladenosine profiling of long non‐coding RNA in colorectal cancer	19
Roles of IL‐1 and IL‐10 family cytokines in the progression of systemic lupus erythematosus: Friends or foes?	19
The effect of Chinese herbal medicine on digestive system and liver functions should not be neglected in COVID‐19: An updated systematic review and meta‐analysis	19
Not all mitochondrial DNAs are made equal and the nucleus knows it	19
p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation	19
Gallic acid‐gold nanoparticles enhance radiation‐induced cell death of human glioma U251 cells	18
Reference intervals for routine biochemical markers and body mass index: A study based on healthcare center database in northeastern Iran	18
Small nucleolar RNA host genes promoting epithelial–mesenchymal transition lead cancer progression and metastasis	18
2‐Deoxy‐d‐glucose exploits increased glucose metabolism in cancer and viral‐infected cells: Relevance to its use in India against SARS‐CoV‐2	17
The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions	17
Autophagy drives plasticity and functional polarization of tumor‐associated macrophages	17
Kinetochore‐catalyzed MCC formation: A structural perspective	16
Central nervous system cholesterol metabolism in health and disease	16
Cancer combination therapies by silencing of CTLA‐4, PD‐L1, and TIM3 in osteosarcoma	16
Knockdown of lncRNA TTTY15 alleviates myocardial ischemia–reperfusion injury through the miR‐374a‐5p/FOXO1 axis	16
Impact of supplementation with vitamins B₆, B₁₂, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A sys	16
HOXA5 induces M2 macrophage polarization to attenuate carotid atherosclerosis by activating MED1	15
The mechanism research on the anti‐liver fibrosis of emodin based on network pharmacology	15
Angiotensin‐converting enzyme 2: A protective factor in regulating disease virulence of SARS‐COV‐2	15
Long noncoding RNA small nucleolar RNA host gene 15 deteriorates liver cancer via microRNA‐18b‐5p/LIM‐only 4 axis	15
Ginkgolide C promotes apoptosis and abrogates metastasis of colorectal carcinoma cells by targeting Wnt/β‐catenin signaling pathway	15
Circ_0109046 promotes the malignancy of endometrial carcinoma cells through the microRNA‐105/SOX9/Wnt/β‐catenin axis	15
LMNB2 is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma	14
Ferulic acid ameliorates acetaminophen‐induced acute liver injury by promoting AMPK‐mediated protective autophagy	14
Cholesterol‐dependent cytolysins: The outstanding questions	14
Mitochondrial iron and calcium homeostasis in Friedreich ataxia	14
Mitochondrial E3 ubiquitin ligase 1 (MUL1) as a novel therapeutic target for diseases associated with mitochondrial dysfunction	14
Mammalian iron sulfur cluster biogenesis and human diseases	14

Knockdown of ST6Gal‐I expression in human hepatocellular carcinoma cells inhibits their exosome‐mediated proliferation‐ and migration‐promoting effects	14
CP‐25 exerts therapeutic effects in mice with dextran sodium sulfate‐induced colitis by inhibiting GRK2 translocation to downregulate the TLR4‐NF‐κB‐NLRP3 inflammasome	13
Ursolic acid ameliorates hypobaric hypoxia‐induced skeletal muscle protein loss via upregulating Akt pathway: An experimental study using rat model	13
LncRNA UCA1 remits LPS‐engendered inflammatory damage through deactivation of miR‐499b‐5p/TLR4 axis	13
Epigenetic targeting of SLC30A3 by HDAC1 is related to the malignant phenotype of glioblastoma	13
Silencing of long non‐coding RNADLX6‐AS1 weakens neuroblastoma progression by the miR‐513c‐5p/PLK4 axis	13
The mechanism of sitagliptin inhibition of colorectal cancer cell lines' metastatic functionalities	12
PD‐1/PD‐L1 blockade: Prospectives for immunotherapy in cancer and autoimmunity	12
Autophagy and antiviral defense	12
Tea bioactive components prevent carcinogenesis via anti‐pathogen, anti‐inflammation, and cell survival pathways	12
Urinary proteomic analysis to identify a potential protein biomarker panel for the diagnosis of tuberculosis	11
TAR DNA‐binding protein 43 oligomers in physiology and pathology	11
Mitochondrial transport and metabolism of the major methyl donor and versatile cofactor S‐adenosylmethionine, and related diseases: A review^†	11
Silencing of lncRNA Gm14461 alleviates pain in trigeminal neuralgia through inhibiting astrocyte activation	11
Enhancer of zeste homolog 2 participates in the process of atherosclerosis by modulating microRNA‐139‐5p methylation and signal transducer and activator of transcription 1 expres	11
Induced effect of zinc oxide nanoparticles on human acute myeloid leukemia cell apoptosis by regulating mitochondrial division	11
The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses	11
Epigenetic transcripts of LINC01311 and hsa‐miR‐146a‐5p regulate neural development in a cellular model of Alzheimer's disease	11
The redox signal: A physiological perspective	10
An overview of the innate and adaptive immune system in atherosclerosis	10
miR‐126 regulates the proliferation, migration, invasion, and apoptosis of non‐small lung cancer cells via AKT2/HK2 axis	10
Mast cells: Therapeutic targets for COVID‐19 and beyond	10
Novel therapeutic regimens for urethane‐induced early lung cancer in rats: Combined cisplatin nanoparticles with vitamin‐D₃	10
The multifaceted antineoplastic role of pyrimethamine against human malignancies	10
The LINC01410/miR‐122‐5p/NDRG3 axis is involved in the proliferation and migration of osteosarcoma cells	10
Non‐coding RNA regulatory networks in post‐transcriptional regulation of VEGFA in cancer	10
Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes	10
Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta‐analysis	10
Evaluating the therapeutic efficacy of radiolabeled BSA@CuS nanoparticle‐induced radio‐photothermal therapy against anaplastic thyroid cancer	10
Thirteen dubious ways to detect conserved structural RNAs	10
Mammalian iron sulfur cluster biogenesis: From assembly to delivery to recipient proteins with a focus on novel targets of the chaperone and co‐chaperone proteins	10
A standardised nomenclature for long non‐coding RNAs	10
Bromodomain‐containing protein 9 is a prognostic biomarker associated with immune infiltrates and promotes tumor malignancy through activating notch signaling pathway in negative HIF‐2α cle	9
The role of the proteasome in mitochondrial protein quality control	9
Biosynthesis of uridine diphosphate N‐Acetylglucosamine: An underexploited pathway in the search for novel antibiotics?	9
The role of Escherichia coli FhlA transcriptional activator in generation of proton motive force and F_OF₁‐ATPase activity at pH 7.5	9
RNPS1 functions as an oncogenic splicing factor in cervical cancer cells	9
The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation	9
Autophagy and cancer metabolism—The two‐way interplay	9
The roles of proteases in prostate cancer	9
Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA‐223/TXNIP/Wnt/β‐catenin pathway	9
MicroRNA‐216a targets WT1 expression and regulates KRT7 transcription to mediate the progression of pancreatic cancer—A transcriptome analysis	9
Nanotized curcumin‐benzothiophene conjugate: A potential combination for treatment of cerebral malaria	8
Effects of different autophagy inhibitors on sensitizing KG‐1 and HL‐60 leukemia cells to chemotherapy	8
The ins and outs of the flavin mononucleotide cofactor of respiratory complex I	8
Inhibited histone deacetylase 3 ameliorates myocardial ischemia–reperfusion injury in a rat model by elevating microRNA‐19a‐3p and reducing cyclin‐dependent kinase 2	8
Elevated microRNA‐130b‐5p or silenced ELK1 inhibits self‐renewal ability, proliferation, migration, and invasion abilities, and promotes apoptosis of cervical cancer stem cells	8
MiR‐548k suppresses apoptosis in breast cancer cells by affecting PTEN/PI3K/AKT signaling pathway	8
Selectively targeting cancer stem cells: Current and novel therapeutic strategies and approaches in the effective eradication of cancer	8
Inorganic phosphate‐induced cytotoxicity	8
Expanding role of ribosome‐inactivating proteins: From toxins to therapeutics	8
LINC00261/microRNA‐550a‐3p/SDPRaxis affects the biological characteristics of breast cancer stem cells	8
Cytochrome c oxidase‐modulatory near‐infrared light penetration into the human brain: Implications for the noninvasive treatment of ischemia/reperfusion injury	8
Endogenous dipeptide‐carnosine supplementation ameliorates hypobaric hypoxia‐induced skeletal muscle loss via attenuating endoplasmic reticulum stress response and maintaining proteostasis	8
The effects of 1,25(OH)₂D₃ treatment on immune responses and intracellular metabolic pathways of bone marrow‐derived dendritic cells from lean an	7
Novel NRF2‐activated cancer treatments utilizing synthetic lethality	7
Effects of the MTOR and AKT1 genes polymorphisms on papillary thyroid cancer development	7
Mesenchymal stem cells (MSCs) and MSC‐derived exosomes in animal models of central nervous system diseases: Targeting the NLRP3 inflammasome	7
Atg16l1 in dendritic cells is required for antibacterial defense and autophagy in murine colitis	7
The effects of sulfated hyaluronan in breast, lung and colorectal carcinoma and monocytes/macrophages cells: Its role in angiogenesis and tumor progression	7
Tuberculosis comorbidity with rheumatoid arthritis: Gene signatures, associated biomarkers, and screening	7
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non‐Small cell lung cancer and inhibit tumor progression	7
M2‐polarization‐related CNTNAP1 gene might be a novel immunotherapeutic target and biomarker for clear cell renal cell carcinoma	7
Impact of natural mutations on the riboflavin transporter 2 and their relevance to human riboflavin transporter deficiency 2	7
Serum albumin and nucleic acids biodistribution: From molecular aspects to biotechnological applications	7
LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study	7