IUBMB Life

Article	Citations
Variability in the levels of exosomal miRNAs among human subjects could be explained by differential interactions of exosomes with the endothelium	68
The heparan sulphate proteoglycan Syndecan‐1 (CD138) regulates tumour progression in a 3D model of ductal carcinoma in situ of the breast	61
Anti‐inflammatory effects of sodium‐glucose cotransporter‐2 inhibitors in COVID‐19	45
Retraction	43
Retraction	43
Simultaneous blockade of the CD73/EGFR axis inhibits tumor growth	33
Integrated multi‐omics and machine learning reveal a gefitinib resistance signature for prognosis and treatment response in lung adenocarcinoma	32
Cytokeratin 13 promotes radiotherapy sensitivity of nasopharyngeal carcinoma by downregulating the MEK/ERK pathway	31
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Mammalian iron sulfur cluster biogenesis and human diseases	30
The history of IUBMB Life (1980–2020)	29
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Inorganic phosphate‐induced cytotoxicity	28
Nuclear and cytoplasmic lncRNAs in root tips of the model legume Medicago truncatula under control and submergence	27
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Addressing the impact of high glucose microenvironment on the immunosuppressive characteristics of human mesenchymal stem cells	23
Bromodomain‐containing protein 9 is a prognostic biomarker associated with immune infiltrates and promotes tumor malignancy through activating notch signaling pathway in negative HIF‐2α cle	23
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Mitochondrial iron and calcium homeostasis in Friedreich ataxia	23
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Oral administration of herbal oligonucleotide drug JGL‐sRNA‐h7 ameliorates hyperglycemia in db/db mice and beagle dogs	20
Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow	20
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PD‐1/PD‐L1 blockade: Prospectives for immunotherapy in cancer and autoimmunity	19
A hybrid approach to assess the structural impact of long noncoding RNA mutations uncovers key NEAT1 interactions in colorectal cancer	19
Comparative analysis of the potential of the secretomes of cardiac resident stromal cells and fibroblasts	19
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Lobeline: A multifunctional alkaloid modulates cholinergic and glutamatergic activities	18
A standardised nomenclature for long non‐coding RNAs	17
Maternal Socs3 knockdown attenuates postnatal obesity caused by an early life environment of maternal obesity and intrauterine overnutrition in progeny mice	17
Activation of E3 ubiquitin ligase WWP2 by non‐receptor tyrosine kinase ACK1	16
Mitochondrial protein and organelle quality control—Lessons from budding yeast	16
β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts	16
LncRNA RP11‐301G19.1 is required for the maintenance of vascular smooth muscle cell contractile phenotype via sponging miR‐17‐5P/ATOH8 axis	16
Impact of supplementation with vitamins B6, B12, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A sys	15
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miR‐543 in human mesenchymal stem cell–derived exosomes promotes cardiac microvascular endothelial cell angiogenesis after myocardial infarction through COL4A1	15
Diminished substrate‐mediated cardiac mitochondrial respiration and elevated autophagy in adult male offspring of gestational diabetic rats	14
Mimicking human riboflavin responsive neuromuscular disorders by silencing flad‐1 gene in C. elegans: Alteration of vitamin transport and cholinergic transmission	14
The roles of proteases in prostate cancer	14
The CD40/CD40 ligand dyad and its downstream effector molecule ISG54 in relating acute neuroinflammation with persistent, progressive demyelination	14
Serum/glucocorticoid‐regulated kinase 1‐targeted transient receptor potential oxalate subtype 1 regulates bladder smooth muscle cell proliferation due to bladder outlet obstruction in mice via activat	14
Thiourea derivatives inhibit key diabetes‐associated enzymes and advanced glycation end‐product formation as a treatment for diabetes mellitus	13
Resistance to prostate cancer treatments	13
Amyloid‐β40 E22K fibril in familial Alzheimer's disease is more thermostable and susceptible to seeding	13
RNPS1 functions as an oncogenic splicing factor in cervical cancer cells	13
iTRAQ‐based proteomic analysis of 17β‐Estradiol‐induced anti‐proliferation and apoptosis in mouse thymic epithelial cells by disturbing ribosomal biogenesis	12
Fingolimod (FTY720), an FDA‐approved sphingosine 1‐phosphate (S1P) receptor agonist, restores endothelial hyperpermeability in cellular and animal models of dengue vir	12
Decreased differentiation capacity and altered expression of extracellular matrix components in irradiation‐mediated senescent human breast adipose‐derived stem cells	12
Bencaosome [16:0 Lyso PA+XLGB28‐sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice	11
m6A transferase KIAA1429‐stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1	11
Autophagy and cancer metabolism—The two‐way interplay	11
Central nervous system cholesterol metabolism in health and disease	11
Gastrointestinal tissue as a “new” target of pollution exposure	11
LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study	11
Erratum	10
SNHG14 promotes triple‐negative breast cancer cell proliferation, invasion, and chemoresistance by regulating the ERK/MAPK signaling pathway	10
The role of the proteasome in mitochondrial protein quality control	10
SHP2: The protein tyrosine phosphatase involved in chronic pulmonary inflammation and fibrosis	10
Extracellular adenosine oppositely regulates the purinome machinery in glioblastoma and mesenchymal stem cells	10
Greater TIMP‐1 protein levels and neointimal formation represent sex‐dependent cellular events limiting aortic vessel expansion in female rats	10
p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation	10
Correction to “Association of nonalcoholic fatty liver disease with a single nucleotide polymorphism on the gene encoding leptin receptor”	10
Irisin alleviates the pyroptosis of β cells in T2DM by inhibiting NLRP3 inflammasome through regulating miR‐19b‐3p/SOCS3/STAT3 axis mediated auto	10
Microtubule depolymerization induces ferroptosis in neuroblastoma cells	10
Mesenchymal stem cells (MSCs) and MSC‐derived exosomes in animal models of central nervous system diseases: Targeting the NLRP3 inflammasome	10
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non‐Small cell lung cancer and inhibit tumor progression	10
Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway	9
The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses	9

Tinagl1 restores tamoxifen sensitivity and blocks fibronectin‐induced EMT by simultaneously blocking the EGFR and β1‐integrin/FAK signaling pathways in tamoxifen‐resis	9
EXPRESSION OF CONCERN: Laccase Treatment Impairs Bisphenol A‐Induced Cancer Cell Proliferation Affecting Estrogen Receptor α‐Dependent Rapid Signals	9
The latest achievements in biochemistry, biophysics and biotechnology—50 years of history of the Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, Poland	9
Human disease‐causing missense genetic variants are enriched in the evolutionarily ancient domains of the cytosolic aminoacyl‐tRNA synthetase proteins	9
Erratum to Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta‐analysis	9
Deciphering the senescence‐based tumoral heterogeneity and characteristics in pancreatic cancer: Results from parallel bulk and single‐cell transcriptome data	9
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YTHDF3 rs7464 A > G polymorphism increases Chinese neuroblastoma risk: A multiple‐center case–control study	8
Combined doxorubicin and arctigenin treatment induce cell cycle arrest‐associated cell death by promoting doxorubicin uptake in doxorubicin‐resistant breast cancer cells	7
Cyclin‐dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway	7
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N1‐methyladenosine profiling of long non‐coding RNA in colorectal cancer	7
Herbal inhibitors of SARS‐CoV‐2 Mpro effectively ameliorate acute lung injury in mice	7
LncRTPred: Predicting RNA–RNA mode of interaction mediated by lncRNA	7
Mast cells: Therapeutic targets for COVID‐19 and beyond	7
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Low expression of PCK2 in breast tumors contributes to better prognosis by inducing senescence of cancer cells	6
Exosomes derived from Baicalin‐pretreated bone mesenchymal stem cells improve Th17/Treg imbalance after hepatic ischemia–reperfusion via FGF21 and the JAK2/STAT3<	6
Involvement of sialoglycans in SARS‐COV‐2 infection: Opportunities and challenges for glyco‐based inhibitors	6
Thrombospondins in human aortic aneurysms	6
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Condition‐dependent structural collapse in the intrinsically disordered N‐terminal domain of prion protein	6
Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross‐talk with p53 to activate p21	6
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Recent advances in BCRP‐induced breast cancer resistance treatment with marine‐based natural products	6
ENSMUST00000147869 regulates proliferation and fibrosis of mesangial cells in diabetic nephropathy by interacting with Hspa9	6
Functional TET2 gene polymorphisms increase the risk of neuroblastoma in Chinese children	6
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Humanized disulfide‐stabilized diabody against fibroblast growth factor‐2 inhibits PD‐L1 expression and epithelial‐mesenchymal transition in hepatoma cells through STAT3	6
Transcriptional regulatory networks of the proteasome in mammalian systems	6
MST4 as a novel therapeutic target for autophagy and radiosensitivity in gastric cancer	6
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Endogenous dipeptide‐carnosine supplementation ameliorates hypobaric hypoxia‐induced skeletal muscle loss via attenuating endoplasmic reticulum stress response and maintaining proteostasis	5
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Arabidopsis thaliana possesses two novel ELL associated factor homologs	5
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miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response	5
Stem cell genes in atheromatosis: The role of Klotho, HIF1α, OCT4, and BMP4	5
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Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer	5
Reflections on the 50‐year history of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB)	5
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Screening and experimental validation of diagnostic gene in ulcerative colitis with anti‐TNF‐α therapy	5
Placenta‐specific protein 1 promotes cell proliferation via the AKT/GSK‐3β/cyclin D1 signaling pathway in gastric cancer	5
William “Bill” Joseph Whelan, D.Sc., FRS November 14, 1924 to June 5, 2021	5
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Genetic tools to dissect functions of long noncoding RNAs	5
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Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP‐1 expression, and the STAT3 pathway	4
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Apurinic/apyrimidinic endonuclease 1 has major impact in prevention of suicidal covalent DNA–protein crosslink with apurinic/apyrimidinic site in cellular extracts	4
Hyaluronan as “Agent Smith” in cancer extracellular matrix pathobiology: Regulatory roles in immune response, cancer progression and targeting	4
Potential COVID‐19 remedies from repurposed drugs and herbal small RNAs	4
FOXO transcription factors in antioxidant defense	4
Selectively targeting cancer stem cells: Current and novel therapeutic strategies and approaches in the effective eradication of cancer	4
Hederagenol improves multiple sclerosis by modulating Th17 cell differentiation	4
miR‐126 regulates the proliferation, migration, invasion, and apoptosis of non‐small lung cancer cells via AKT2/HK2 axis	4
Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high‐fat diet	4
Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role	4
Hormesis: Transforming disciplines that rely on the dose response	4
Regulation of innate immune signaling pathways by autophagy in dengue virus infection	4
N6‐methyladenosine regulators are potential prognostic biomarkers for multiple myeloma	4
MRASin coronary artery disease—Unchartered territory	4
Identification of mutation resistance coldspots for targeting the SARS‐CoV2 main protease	3
Cholesterol‐dependent cytolysins: The outstanding questions	3
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Neuroprotective effects of resveratrol through modulation of PI3K/Akt/GSK‐3β pathway and metalloproteases	3
lncRNAs: New players of cancer drug resistance via targeting ABC transporters	3
Utilizing adeno‐associated virus as a vector in treating genetic disorders or human cancers	3

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Underlying selection for the diversity of spike protein sequences of SARS‐CoV‐2	3
Mammalian iron sulfur cluster biogenesis: From assembly to delivery to recipient proteins with a focus on novel targets of the chaperone and co‐chaperone proteins	3
Non‐coding RNA regulatory networks in post‐transcriptional regulation of VEGFA in cancer	3
The ins and outs of the flavin mononucleotide cofactor of respiratory complex I	3
Optimization of the chromium (Cr+6) reduction from waterways using chemically and bacterially treated agro‐waste	3
Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system function	3
CRYAB is upregulated and predicts clinical prognosis in kidney renal clear cell carcinoma	3
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A hub for regulation of mitochondrial metabolism: Fatty acid and lipoic acid biosynthesis	3
The effect of Chinese herbal medicine on digestive system and liver functions should not be neglected in COVID‐19: An updated systematic review and meta‐analysis	3
Circular RNAs in chemotherapy resistance of lung cancer and their potential therapeutic application	3
Combined effect of chrysin and apigenin on inhibiting the development and progression of colorectal cancer by suppressing the activity of P38‐MAPK/AKT pathway	3
RETRACTION: Nutritional Flavonoids Modulate Estrogen Receptor α Signaling	3
Deletion of the polyketide synthase‐encoding gene pks1 prevents melanization in the extremophilic fungus Cryomyces antarcticus	3
The role of the gut microbiome in modulating immunotherapy efficacy in colorectal cancer	3
The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia	2
Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease	2
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Eddy Fischer—Renaissance scientist and bon viveur	2
A decoy strategy to activate the immune system	2
The scientific career and life of Edmond H. Fischer—A personal tribute	2
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Knockdown of ST6Gal‐I expression in human hepatocellular carcinoma cells inhibits their exosome‐mediated proliferation‐ and migration‐promoting effects	2
Long‐term abuse of caffeine sodium benzoate induces endothelial cells injury and leads to coagulation dysfunction	2
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Cancer combination therapies by silencing of CTLA‐4, PD‐L1, and TIM3 in osteosarcoma	2
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KGF secreted from HSCs activates PAK4/BMI1, promotes HCC stemness through PI3K/AKT pathway	2
Neonatal exposure to low‐dose X‐ray causes behavioral defects and abnormal hippocampal development in mice	2
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Mitophagy in aging and longevity	2
Nano‐therapeutics: The upcoming nanomedicine to treat cancer	2
Differentiation of neural stem cells from human olfactory mucosa into dopaminergic neuron‐like cells	2
Dynamic association of flavin cofactors to regulate flavoprotein function	2
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The Saccharomyces cerevisiae mitochondrial DNA polymerase and its contribution to the knowledge about human POLG‐related disorders	2
Cholesteryl ester transfer protein knock‐down in conjunction with a cholesterol‐depleting agent decreases tamoxifen resistance in breast cancer cells	2
CPEB1 enhances erastin‐induced ferroptosis in gastric cancer cells by suppressing twist1 expression	2
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Redefining pseudokinases: A look at the untapped enzymatic potential of pseudokinases	2
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Genetic variations in NER pathway gene polymorphisms and Wilms tumor risk: A six‐center case–control study in East China	1
Enhancing the activation of T cells through anti‐CD3/CD28 magnetic beads by adjusting the antibody ratio	1
The mechanism research on the anti‐liver fibrosis of emodin based on network pharmacology	1
Retraction: miR‐212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical	1
The LINC01410/miR‐122‐5p/NDRG3 axis is involved in the proliferation and migration of osteosarcoma cells	1
2‐Deoxy‐D‐glucose simultaneously targets glycolysis and Wnt/β‐catenin signaling to inhibit cervical cancer progression	1
Comparative effects of on‐pump versus off‐pump coronary artery bypass grafting surgery on serum cytokine and chemokine levels	1
The effects of sulfated hyaluronan in breast, lung and colorectal carcinoma and monocytes/macrophages cells: Its role in angiogenesis and tumor progression	1
The complex relationship between late‐onset caloric restriction and synaptic plasticity in aged Wistar rats	1
The role of Escherichia coli FhlA transcriptional activator in generation of proton motive force and FOF1‐ATPase activity at pH 7.5	1
Characterization of O‐mannosylated proteins profiling in bacillus Calmette–Guérin via gel‐based and gel‐free approaches	1
Genome‐wide CRISPR screening identifies the pivotal role of ANKRD42 in colorectal cancer metastasis through EMT regulation	1
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Glycolipotoxicity conferred tendinopathy through ferroptosis dictation of tendon‐derived stem cells by YAP activation	1
IUBMB focused meeting/FEBS workshop: Crosstalk between nucleus and mitochondria in human disease (CrossMitoNus)	1
AARS Online: A collaborative database on the structure, function, and evolution of the aminoacyl‐tRNA synthetases	1
The mechanism of sitagliptin inhibition of colorectal cancer cell lines' metastatic functionalities	1
Identification of novel key molecular signatures in the pathogenesis of experimental diabetic retinopathy	1
Autophagy inhibition potentiates energy restriction‐induced cell death in hepatocellular carcinoma cells	1
Drosophila as a model to study autophagy in neurodegenerative diseases and digestive tract	1
Serum albumin and nucleic acids biodistribution: From molecular aspects to biotechnological applications	1
Machine learning applications for transcription level and phenotype predictions	1
The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation	1
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Mechanisms of epigenetic regulation of transcription by lncRNAs in plants	1
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Autophagy and antiviral defense	1
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FOXC2‐induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression	1
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CD38/cADPR‐mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1	1
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miR‐455‐5p regulates circadian rhythms by accelerating the degradation of Clock mRNA	1
MicroRNA‐216a targets WT1 expression and regulates KRT7 transcription to mediate the progression of pancreatic cancer—A transcriptome analysis	1
Mitochondrial transport and metabolism of the vitamin B‐derived cofactors thiamine pyrophosphate, coenzyme A,FADandNAD+, and related diseases: A review	1
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1,25(OH)2D3 inhibits Lewis lung cancer cell migration via NHE1‐sensitive metabolic reprograming	1
Evolution and variation in amide aminoacyl‐tRNA synthesis	1
Central nervous system organoids for modeling neurodegenerative diseases	1
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MiR‐3680‐3p is a novel biomarker for the diagnosis and prognosis of liver cancer and is involved in regulating the progression of liver cancer	1
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Pore‐forming aegerolysin and MACPF proteins in extremotolerant or extremophilic fungi	1
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Inhibition of transglutaminase 2 inhibits ionizing radiation‐induced cellular senescence in skin keratinocytes in vitro	0
The up‐regulation of RIPK3 mediated by ac4C modification promotes oxidative stress‐induced granulosa cell senescence by inhibiting the Nrf2/HO‐1 pathway	0
Circ_0072088 promotes progression of hepatocellular carcinoma by activating JAK2/STAT3 signaling pathway via miR‐375	0
T‐cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer	0
APOC1 inhibit NKTCL doxorubicin sensitivity by promoting mitophagy	0
Naringin‐generated ROS promotes mitochondria‐mediated apoptosis in Candida albicans	0
Correction to “Retraction”	0
Roles of IL‐1 and IL‐10 family cytokines in the progression of systemic lupus erythematosus: Friends or foes?	0