IUBMB Life

Article	Citations
Issue Information	76
Anti‐inflammatory effects of sodium‐glucose cotransporter‐2 inhibitors in COVID‐19	73
Issue Information	70
Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow	58
Irisin alleviates the pyroptosis of β cells in T2DM by inhibiting NLRP3 inflammasome through regulating miR‐19b‐3p/SOCS3/STAT3 axis mediated auto	47
SHP2: The protein tyrosine phosphatase involved in chronic pulmonary inflammation and fibrosis	43
LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study	40
Thiourea derivatives inhibit key diabetes‐associated enzymes and advanced glycation end‐product formation as a treatment for diabetes mellitus	38
Integrated multi‐omics and machine learning reveal a gefitinib resistance signature for prognosis and treatment response in lung adenocarcinoma	37
Mitochondrial protein and organelle quality control—Lessons from budding yeast	36
Serum/glucocorticoid‐regulated kinase 1‐targeted transient receptor potential oxalate subtype 1 regulates bladder smooth muscle cell proliferation due to bladder outlet obstruction in mice via activat	35
SNHG14 promotes triple‐negative breast cancer cell proliferation, invasion, and chemoresistance by regulating the ERK/MAPK signaling pathway	34
The roles of proteases in prostate cancer	32
Gastrointestinal tissue as a “new” target of pollution exposure	30
The role of the proteasome in mitochondrial protein quality control	29
Issue Information	29
Central nervous system cholesterol metabolism in health and disease	28
	27
Low expression of PCK2 in breast tumors contributes to better prognosis by inducing senescence of cancer cells	27
Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer	25
miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response	24
MST4 as a novel therapeutic target for autophagy and radiosensitivity in gastric cancer	24
Non‐coding RNA regulatory networks in post‐transcriptional regulation of VEGFA in cancer	23
Arabidopsis thaliana possesses two novel ELL associated factor homologs	23
miR‐126 regulates the proliferation, migration, invasion, and apoptosis of non‐small lung cancer cells via AKT2/HK2 axis	23

Circular RNAs in chemotherapy resistance of lung cancer and their potential therapeutic application	22
RETRACTION: Nutritional Flavonoids Modulate Estrogen Receptor α Signaling	21
Neuroprotective effects of resveratrol through modulation of PI3K/Akt/GSK‐3β pathway and metalloproteases	21
Optimization of the chromium (Cr+6) reduction from waterways using chemically and bacterially treated agro‐waste	21
Potential COVID‐19 remedies from repurposed drugs and herbal small RNAs	20
Combined doxorubicin and arctigenin treatment induce cell cycle arrest‐associated cell death by promoting doxorubicin uptake in doxorubicin‐resistant breast cancer cells	20
Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP‐1 expression, and the STAT3 pathway	19
Cholesterol‐dependent cytolysins: The outstanding questions	19
N6‐methyladenosine regulators are potential prognostic biomarkers for multiple myeloma	19
Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high‐fat diet	17
Issue Information	17
FOXO transcription factors in antioxidant defense	17
Underlying selection for the diversity of spike protein sequences of SARS‐CoV‐2	17
Issue Highlights	16
	16
Dynamic association of flavin cofactors to regulate flavoprotein function	15
CD38/cADPR‐mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1	15
Central nervous system organoids for modeling neurodegenerative diseases	15
Mechanisms of epigenetic regulation of transcription by lncRNAs in plants	14
Overexpression of RGPR‐p117 reveals anticancer effects by regulating multiple signaling pathways in bone metastatic human breast cancer MDA‐MB‐231 cells	14
One‐year mortality and consequences of COVID‐19 in cancer patients: A cohort study	14
Eddy Fischer—Renaissance scientist and bon viveur	14
Issue Information	14
Adverse fetal and neonatal impact of war conflicts during pregnancy: A systematic review	14
Knockdown of ST6Gal‐I expression in human hepatocellular carcinoma cells inhibits their exosome‐mediated proliferation‐ and migration‐promoting effects	14
Issue Information	14
Unraveling antiviral efficacy of multifunctional immunomodulatory triterpenoids against SARS‐COV‐2 targeting main protease and papain‐like protease	13
2‐Deoxy‐d‐glucose exploits increased glucose metabolism in cancer and viral‐infected cells: Relevance to its use in India against SARS‐CoV‐2	13
2‐Deoxy‐D‐glucose simultaneously targets glycolysis and Wnt/β‐catenin signaling to inhibit cervical cancer progression	13
Enhanced HER2 status detection in breast and gastric cancers using surrogate DNA methylation markers	13
Issue Highlights	12
Issue Information	12
Particulate matters 2.5 induce tumor progression in lung cancer by increasing the activity of hnRNPA2B1 resulting in retarding mRNA decay of oxidative phosphorylation	12
Urinary proteomic analysis to identify a potential protein biomarker panel for the diagnosis of tuberculosis	12
Cover Image	11
Lectins CGL and MTL, representatives of mytilectin family, exhibit different antiproliferative activity in Burkitt's lymphoma cells	11
The up‐regulation of RIPK3 mediated by ac4C modification promotes oxidative stress‐induced granulosa cell senescence by inhibiting the Nrf2/HO‐1 pathway	11
Issue Information	11
Mitochondrial respiratory supercomplexes of the yeast Saccharomyces cerevisiae	11
Experimental evolution of extremotolerant and extremophilic fungi under osmotic stress	11
Issue Information	11
Issue Information	11
Role of extracellular vesicles in mitochondrial eye diseases	11
Adaptation of cardiomyogenesis to the generation and maturation of cardiomyocytes from human pluripotent stem cells	11
	11
Issue Highlights	11
Erythroid spectrin binding modulates peroxidase and catalase activity of heme proteins	11
Imperative connotation of SODs in cancer: Emerging targets and multifactorial role of action	10
Neuroprotection and mechanisms of ginsenosides in nervous system diseases: Progress and perspectives	10
RNA processing and degradation mechanisms shaping the mitochondrial transcriptome of budding yeasts	10

Pseudoexfoliation syndrome: The critical role of the extracellular matrix in pathogenesis and treatment	10
Endoplasmic reticulum stress and NF‐kB activation in SARS‐CoV‐2 infected cells and their response to antiviral therapy	10
	9
Depletion of macrophages and osteoclast precursors mitigates iron overload‐mediated bone loss	9
Corrigendum	9
	9
RetroGREAT signaling: The lessons we learn from yeast	9
Genomic features of lichen‐associated black fungi	9
Greater TIMP‐1 protein levels and neointimal formation represent sex‐dependent cellular events limiting aortic vessel expansion in female rats	8
Cover Image	8
Desaturases: Structural and mechanistic insights into the biosynthesis of unsaturated fatty acids	8
Ferulic acid ameliorates acetaminophen‐induced acute liver injury by promoting AMPK‐mediated protective autophagy	8
Variability in the levels of exosomal miRNAs among human subjects could be explained by differential interactions of exosomes with the endothelium	8
Early steps in the biogenesis of mitochondrially encoded oxidative phosphorylation subunits	8
EXPRESSION OF CONCERN: Laccase Treatment Impairs Bisphenol A‐Induced Cancer Cell Proliferation Affecting Estrogen Receptor α‐Dependent Rapid Signals	8
Parecoxib inhibits tumorigenesis and angiogenesis in hepatocellular carcinoma through ERK–VEGF/MMPs signaling pathway	8
A standardised nomenclature for long non‐coding RNAs	7
CRYAB is upregulated and predicts clinical prognosis in kidney renal clear cell carcinoma	7
Stem cell genes in atheromatosis: The role of Klotho, HIF1α, OCT4, and BMP4	7
Correction to “Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells”	7
miR‐543 in human mesenchymal stem cell–derived exosomes promotes cardiac microvascular endothelial cell angiogenesis after myocardial infarction through COL4A1	7
	7
Placenta‐specific protein 1 promotes cell proliferation via the AKT/GSK‐3β/cyclin D1 signaling pathway in gastric cancer	7
	7
Comparative analysis of the potential of the secretomes of cardiac resident stromal cells and fibroblasts	7
KGF secreted from HSCs activates PAK4/BMI1, promotes HCC stemness through PI3K/AKT pathway	7
N1‐methyladenosine profiling of long non‐coding RNA in colorectal cancer	7
Golgi quality control and autophagy	6
Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role	6
Cover Image	6
	6
The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia	6
FOXC2‐induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression	6
Structure–function relationships between the human bitter taste receptor TAS2R38 and propylthiouracil: An in‐silico investigation	6
A decoy strategy to activate the immune system	6
Regulation of innate immune signaling pathways by autophagy in dengue virus infection	6
The Saccharomyces cerevisiae mitochondrial DNA polymerase and its contribution to the knowledge about human POLG‐related disorders	6
The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation	6
Pore‐forming aegerolysin and MACPF proteins in extremotolerant or extremophilic fungi	6
Issue Information	6
The ins and outs of the flavin mononucleotide cofactor of respiratory complex I	6
Correction to “Astrakurkurone, a Sesquiterpenoid From Wild Edible Mushroom, Targets Liver Cancer Cells by Modulating Bcl‐2 Family Proteins”	6
Issue Highlights	6
Cover Image	5
Erratum	5
Issue Information	5
Issue Information	5
	5
Correction to “Retraction”	5
Issue Information	5
Cofactors and pathogens: Flavin mononucleotide and flavin adenine dinucleotide (FAD) biosynthesis by the FAD synthase from Brucella ovis	5
N‐acetylneuraminic acid modulates SQSTM1/p62 sialyation‐mediated ubiquitination degradation contributing to vascular endothelium dysfunction in experimental atherosclerosis mice	5
Nano‐therapeutics: The upcoming nanomedicine to treat cancer	5
Issue Highlights	5
Mechanisms of adaptive hypertrophic cardiac remodeling in a large animal model of premature ventricular contraction‐induced cardiomyopathy	5
Thiouracil and triazole conjugate induces autophagy through the downregulation of Wnt/β‐catenin signaling pathway in human breast cancer cells	5
Correction to “LncRNA RAD51‐AS1/miR‐29b/c‐3p/NDRG2 crosstalk repressed proliferation, invasion and glycolysis of colorectal cancer”	5
Il‐6 and UGT1A1 variations may related to furosemide resistance in heart failure patients	5
1,25(OH)2D3 inhibits Lewis lung cancer cell migration via NHE1‐sensitive metabolic reprograming	5
CPEB1 enhances erastin‐induced ferroptosis in gastric cancer cells by suppressing twist1 expression	5
The redox signal: A physiological perspective	5
Issue Information	5
Analyzing the role of ferroptosis in ribosome‐related bone marrow failure disorders: From pathophysiology to potential pharmacological exploitation	5
Corrigendum	5
The multifaceted antineoplastic role of pyrimethamine against human malignancies	5
	4
Biolistic transformation of the yeast Saccharomyces cerevisiae mitochondrial DNA	4
Pyrimidine–triazole‐tethered tert‐butyl‐piperazine‐carboxylate suppresses breast cancer by targeting estrogen receptor signaling and β‐catenin activation	4
Wnt signaling in cell adhesion, development, and colon cancer	4
Issue Information	4
High cholesterol diet activates ER stress mediated apoptosis in testes tissue: Role of α‐tocopherol	4
Machine learning‐based establishment and validation of age‐related patterns for predicting prognosis in non‐small cell lung cancer within the context of the tumor microenvironment	4
	4
	4
Ginkgolide C promotes apoptosis and abrogates metastasis of colorectal carcinoma cells by targeting Wnt/β‐catenin signaling pathway	4
Mimicking human riboflavin responsive neuromuscular disorders by silencing flad‐1 gene in C. elegans: Alteration of vitamin transport and cholinergic transmission	4
Deciphering the senescence‐based tumoral heterogeneity and characteristics in pancreatic cancer: Results from parallel bulk and single‐cell transcriptome data	4
Disrupted cellular calcium homeostasis is responsible for Aβ‐induced learning and memory damage and lifespan shortening in a model of Aβ transgenic fly	4
The long intergenic noncoding RNA ARES modulates root architecture in Arabidopsis	4
Cover Image	4

Delivery of AKT1 phospho‐forms to human cells reveals differential substrate selectivity	4
	4
	4
Issue Information	3
Issue Information	3
Humanized disulfide‐stabilized diabody against fibroblast growth factor‐2 inhibits PD‐L1 expression and epithelial‐mesenchymal transition in hepatoma cells through STAT3	3
Issue Information	3
The CD40/CD40 ligand dyad and its downstream effector molecule ISG54 in relating acute neuroinflammation with persistent, progressive demyelination	3
Amyloid‐β40 E22K fibril in familial Alzheimer's disease is more thermostable and susceptible to seeding	3
MRASin coronary artery disease—Unchartered territory	3
Issue Highlights	3
Selectively targeting cancer stem cells: Current and novel therapeutic strategies and approaches in the effective eradication of cancer	3
Involvement of sialoglycans in SARS‐COV‐2 infection: Opportunities and challenges for glyco‐based inhibitors	3
Mammalian iron sulfur cluster biogenesis and human diseases	3
Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway	3
Condition‐dependent structural collapse in the intrinsically disordered N‐terminal domain of prion protein	3
Reflections on the 50‐year history of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB)	3
Hederagenol improves multiple sclerosis by modulating Th17 cell differentiation	3
Issue Highlights	3
p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation	3
Machine learning applications for transcription level and phenotype predictions	2
Issue Information	2
Cover Image	2
The increased expression of cytokeratin 13 leads to an increase in radiosensitivity of nasopharyngeal carcinoma HNE‐3 cells by upregulating ERRFI1	2
Intracellular innate immunity and mechanism of action of cytosolic nucleic acid receptor‐mediated type I IFN against viruses	2
miRNAs are now starring in “No Time to Die: Overcoming the chemoresistance in cancer”	2
Aminoacyl‐tRNA synthetase defects in neurological diseases	2
MiR‐3680‐3p is a novel biomarker for the diagnosis and prognosis of liver cancer and is involved in regulating the progression of liver cancer	2
Retraction: miR‐212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical	2
Enhancing the activation of T cells through anti‐CD3/CD28 magnetic beads by adjusting the antibody ratio	2
Hypoxia inducible factor 3‐alpha promotes a malignant phenotype in colorectal cancer cells	2
Cover Image	2
Issue Information	2
Identification, subcellular localization, and functional comparison of novel Yap splicing isoforms in mouse embryonic stem cells	2
A high‐throughput approach to predict A‐to‐I effects on RNA structure indicates a change of double‐stranded content in noncoding RNAs	2
Zinc finger protein 169 promotes tumor progress of hepatocellular cancer via up‐regulating cyclin‐dependent kinase 19	2
Cover Image	2
Redefining pseudokinases: A look at the untapped enzymatic potential of pseudokinases	2
Identification of novel key molecular signatures in the pathogenesis of experimental diabetic retinopathy	2
	2
miRNA‐128 and miRNA‐223 regulate cholesterol‐mediated drug resistance in breast cancer	2
Mast cells: Therapeutic targets for COVID‐19 and beyond	2
Novel NRF2‐activated cancer treatments utilizing synthetic lethality	2
Mitochondrial E3 ubiquitin ligase 1 (MUL1) as a novel therapeutic target for diseases associated with mitochondrial dysfunction	2
Standing with giants: W.J. Whelan, a catalyst for international cooperation via the Miami Winter Symposium and the IUBMB	2
Rapamycin treatment unmasks a sex‐specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel	2
	2
KLHL38 facilitates staurosporine‐induced apoptosis in HL‐1 cells via myocardin degradation	2
Cholesteryl ester transfer protein knock‐down in conjunction with a cholesterol‐depleting agent decreases tamoxifen resistance in breast cancer cells	2
Neonatal exposure to low‐dose X‐ray causes behavioral defects and abnormal hippocampal development in mice	2
Issue Information	2
Cyclin‐dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway	2
Screening and experimental validation of diagnostic gene in ulcerative colitis with anti‐TNF‐α therapy	1
	1
Erratum to Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta‐analysis	1
PD‐1/PD‐L1 blockade: Prospectives for immunotherapy in cancer and autoimmunity	1
	1
SIRT6 through PI3K/Akt/mTOR signaling pathway to enhance radiosensitivity of non‐Small cell lung cancer and inhibit tumor progression	1
Roles of IL‐1 and IL‐10 family cytokines in the progression of systemic lupus erythematosus: Friends or foes?	1
LncRNA RP11‐301G19.1 is required for the maintenance of vascular smooth muscle cell contractile phenotype via sponging miR‐17‐5P/ATOH8 axis	1
Maclurin exerts anti‐cancer effects in human osteosarcoma cells via prooxidative activity and modulations ofPARP, p38, andERKsignaling	1
Correction to “The latest achievements in biochemistry, biophysics and biotechnology—50 years of history of the Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków	1
Issue Information	1
Investigation through naphtho[2,3‐a]pyrene on mutated EGFR mediated autophagy in NSCLC: Cellular model system unleashing therapeutic potential	1
Differential expression of HNF1A and HNF1A‐AS1 in colon cancer cells	1
A hybrid approach to assess the structural impact of long noncoding RNA mutations uncovers key NEAT1 interactions in colorectal cancer	1
	1
Issue Information	1
Issue Information	1
Nuclear and cytoplasmic lncRNAs in root tips of the model legume Medicago truncatula under control and submergence	1
β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts	1
Cover Image	1
m6A transferase KIAA1429‐stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1	1
Synergistic integration of deep learning with protein docking in cardiovascular disease treatment strategies	1
	1
Issue Highlights	1
Coexisting bacterial aminoacyl‐tRNAsynthetase paralogs exhibit distinct phylogenetic backgrounds and functional compatibility withEscherichia coli	1
Phosphorylation, compartmentalization, and cardiac function	1
Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt‐driven signaling pathway	1
Microtubule depolymerization induces ferroptosis in neuroblastoma cells	1
A hub for regulation of mitochondrial metabolism: Fatty acid and lipoic acid biosynthesis	1
Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross‐talk with p53 to activate p21	1
Functional TET2 gene polymorphisms increase the risk of neuroblastoma in Chinese children	1
Cover Image	1
CDKN3 as a key regulator of G2M phase in triple‐negative breast cancer: Insights from multi‐transcriptomic analysis	1
Fingolimod (FTY720), an FDA‐approved sphingosine 1‐phosphate (S1P) receptor agonist, restores endothelial hyperpermeability in cellular and animal models of dengue vir	1
Bromodomain‐containing protein 9 is a prognostic biomarker associated with immune infiltrates and promotes tumor malignancy through activating notch signaling pathway in negative HIF‐2α cle	1
Inorganic phosphate‐induced cytotoxicity	1
Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect	1
Genetic tools to dissect functions of long noncoding RNAs	1
Issue Information	1
HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β‐catenin pathway in 6‐OHDA‐induced Parkinson's disease model	1
Biosynthesis of uridine diphosphate N‐Acetylglucosamine: An underexploited pathway in the search for novel antibiotics?	1
The latest achievements in biochemistry, biophysics and biotechnology—50 years of history of the Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, Poland	1
Issue Highlights	1