Environmental Toxicology

(The TQCC of Environmental Toxicology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-11-01 to 2023-11-01.)
PM2.5‐induced pulmonary inflammation via activating of the NLRP3/caspase‐1 signaling pathway69
Effects of polystyrene microbeads on cytotoxicity and transcriptomic profiles in human Caco‐2 cells67
The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase‐1 signaling pathway and oxidative stress in Wistar rats56
Hesperidin protects against the chlorpyrifos‐induced chronic hepato‐renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up‐regulation of PARP‐1/V40
Investigation of the effects of hesperidin administration on abamectin‐induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, autophagy, a37
CircKDM4C upregulates P53 by sponging hsa‐let‐7b‐5p to induce ferroptosis in acute myeloid leukemia35
Effect of cadmium on osteoclast differentiation during bone injury in female mice34
Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes33
TGF‐β1 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro33
Long noncoding RNA H19 acts as a miR‐340‐3p sponge to promote epithelial‐mesenchymal transition by regulating YWHAZ expression in paclitaxel‐resistant breast cancer ce32
Bisphenols B, E, F, and S and 4‐cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A32
CircRNA circ_POLA2 promotes lung cancer cell stemness via regulating the miR‐326/GNB1 axis32
Chrysin ameliorates aluminum phosphide‐induced oxidative stress and mitochondrial damages in rat cardiomyocytes and isolated mitochondria32
Polystyrene nanoplastics exacerbated lipopolysaccharide‐induced necroptosis and inflammation via the ROS/MAPK pathway in mice spleen31
Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA‐PAA nano‐encapsulation on PANC‐1 pancreatic cancer cell line29
Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice29
An assessment of serum‐dependent impacts on intracellular accumulation and genomic response of per‐ and polyfluoroalkyl substances in a placental trophoblast model29
Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis28
Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice28
Melatonin increases the anticancer potential of doxorubicin in Caco‐2 colorectal cancer cells27
Deltamethrin induces apoptosis in cerebrum neurons of quail via promoting endoplasmic reticulum stress and mitochondrial dysfunction27
Developmental toxicity induced by Cu(OH)2 nanopesticide in zebrafish embryos27
Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM2.5 in mice27
Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice27
Acrylamide‐induced hematotoxicity, oxidative stress, and DNA damage in liver, kidney, and brain of catfish (Clarias gariepinus)26
Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of ze26
Cadmium induces ferroptosis and apoptosis by modulating miR‐34a‐5p/Sirt1axis in PC12 cells26
The toxic effects of Fluorene‐9‐bisphenol on porcine oocyte in vitro maturation26
Exosomal lncRNA HMMR‐AS1 mediates macrophage polarization through miR‐147a/ARID3A axis under hypoxia and affects the progression of hepatocellular carcinoma25
PM2.5 induces endothelial dysfunction via activating NLRP3 inflammasome25
Lithium intoxication induced pyroptosis via ROS/NF‐κB/NLRP3 inflammasome regulatory networks in kidney of mice25
Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis24
A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2‐positive breast cancer through regulating ferroptosis24
Silica dust exposure induces pulmonary fibrosis through autophagy signaling24
LncRNA MIR4435‐2HG‐mediated upregulation of TGF‐β1 promotes migration and proliferation of nonsmall cell lung cancer cells24
Protective effect of Diosmin against benzo(a)pyrene‐induced lung injury in Swiss Albino Mice24
Imbalanced inflammatory response in subchronic arsenic‐induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell–cel23
Curcumin functions as an anti‐inflammatory and antioxidant agent on arsenic‐induced hepatic and kidney injury by inhibiting MAPKs/NF‐κB and activating Nrf2 23
Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway23
Overexpression of HIF‐1α enhances the protective effect of mitophagy on steroid‐induced osteocytes apoptosis23
The miRNA‐149‐5p/MyD88 axis is responsible for ursolic acid‐mediated attenuation of the stemness and chemoresistance of non‐small cell lung cancer cells23
ROS‐mediated PERK‐eIF2α‐ATF4 pathway plays an important role in arsenite‐induced L‐02 cells apoptosis via regulating CHOP‐DR5 signaling23
The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells21
Di‐2‐ethylhexyl phthalate (DEHP) induces apoptosis and autophagy of mouse GC‐1 spg cells21
Lagerstroemia speciosa (L.) Pers. triggers oxidative stress mediated apoptosis via intrinsic mitochondrial pathway in HepG2 cells21
Apoptosis induction and ERK/NF‐κB inactivation are associated with magnolol‐inhibited tumor progression in hepatocellular carcinoma in vivo21
Nootkatone improves anxiety‐ and depression‐like behavior by targeting hyperammonemia‐induced oxidative stress in D‐galactosamine model of liver injury21
Emodin protected against synaptic impairment and oxidative stress induced by fluoride in SH‐SY5Y cells by modulating ERK1/2/Nrf2/HO‐1 pathway21
Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling20
Verbascoside inhibits the epithelial‐mesenchymal transition of prostate cancer cells through high‐mobility group box 1/receptor for advanced glycation end‐products/TGF‐β pathway20
Cytotoxicity of naringenin induces Bax‐mediated mitochondrial apoptosis in human lung adenocarcinoma A549 cells20
Di‐(2‐ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice20
Cardioprotective potential of amygdalin against angiotensin II induced cardiac hypertrophy, oxidative stress and inflammatory responses through modulation of Nrf2 and NF‐κB activ20
Resveratrol protects human bronchial epithelial cells against nickel‐induced toxicity via suppressing p38 MAPK, NF‐κB signaling, and NLRP3 inflammasome activation20
An ecofriendly synthesized gold nanoparticles induces cytotoxicity via apoptosis inHepG2cells20
Curcumin suppresses the stemness of non‐small cell lung cancer cells via promoting the nuclear‐cytoplasm translocation of TAZ20
Ginsenoside Rg3 attenuates the osimertinib resistance by reducing the stemness of non‐small cell lung cancer cells20
Calycosin alleviates H2O2‐induced astrocyte injury by restricting oxidative stress through the Akt/Nrf2/HO‐1 signaling pathway19
BRD4 promotes glioma cell stemness via enhancing miR‐142‐5p‐mediated activation of Wnt/β‐catenin signaling19
Therapeutic effects of rocket seeds (Eruca sativa L.) against testicular toxicity and oxidative stress caused by silver nanoparticles injection in rats19
Gallic acid prevents 1, 2‐Dimethylhydrazine induced colon inflammation, toxicity, mucin depletion, and goblet cell disintegration19
Borneol protects against cerulein‐induced oxidative stress and inflammation in acute pancreatitis mice model18
Platinum nanoparticles induced genotoxicity and apoptotic activity in human normal and cancer hepatic cells via oxidative stress‐mediated Bax/Bcl‐2 and caspase‐3 expression18
Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions18
Environmental relevant concentrations of triclosan affected developmental toxicity, oxidative stress, and apoptosis in zebrafish embryos18
Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway18
Bisphenol A induced apoptosis via oxidative stress generation involved Nrf2/HO‐1 pathway and mitochondrial dependent pathways in human retinal pigment epithelium (18
LncRNA MEG3 mediates nickel oxide nanoparticles‐induced pulmonary fibrosis via suppressing TGF‐β1 expression and epithelial‐mesenchymal transition process18
Melatonin ameliorates Bisphenol S induced testicular damages by modulating Nrf‐2/HO‐1 and SIRT‐1/FOXO‐1 expressions17
MiR‐122‐5p and miR‐326‐3p promote cadmium‐induced NRK‐52E cell apoptosis by downregulating PLD117
Plumbagin protects the myocardial damage by modulating the cardiac biomarkers, antioxidants, and apoptosis signaling in the doxorubicin‐induced cardiotoxicity in rats17
Sub‐chronic administration of benzo[a]pyrene disrupts hippocampal long‐term potentiation via inhibiting CaMK II/PKC/PKA‐ERK‐CREB signaling in rats17
Epigenetic modification of H3K4 and oxidative stress are involved in MC‐LR‐induced apoptosis in testicular cells of SD rats17
Assessment of impact of α‐Fe2O3 and γ‐Fe2O3 nanoparticles on phytoplankton species Selenastrum capricornutum and Nannochloropsis oculat16
Mangiferin inhibits lipopolysaccharide‐induced epithelial‐mesenchymal transition (EMT) and enhances the expression of tumor suppressor gene PER1 in non‐small cell lung cancer cells16
Xanthohumol protects against Azoxymethane‐induced colorectal cancer in Sprague‐Dawley rats16
Review on the ecotoxicological impacts of plastic pollution on the freshwater invertebrate Daphnia16
Dual down‐regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells16
Inorganic arsenic‐mediated upregulation of AS3MT promotes proliferation of nonsmall cell lung cancer cells by regulating cell cycle genes16
Tea polyphenols alleviate tri‐ortho‐cresyl phosphate‐induced autophagy of mouse ovarian granulosa cells16
Serum cadmium positively correlates with inflammatory cytokines in patients with chronic obstructive pulmonary disease16
Nigella sativa oil protects against emamectin benzoate‐Induced neurotoxicity in rats16
Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK16
Diosmetin alleviates cerebral ischemia‐reperfusion injury through Keap1‐mediated Nrf2/ARE signaling pathway activation and NLRP3 inflammasome inhibition16
Assessment of DNA damage and oxidative stress in juvenile Channa punctatus (Bloch) after exposure to multi‐walled carbon nanotubes16
Brucine promotes apoptosis in cervical cancer cells (ME‐180) via suppression of inflammation and cell proliferation by regulating PI3K/AKT/mTOR signaling pa15
Bioactive peptides attenuate cardiac apoptosis in spontaneously hypertensive rat hearts through activation of autophagy and mitochondrial biogenesis pathway15
Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K/Akt pathway15
Oral exposure of titanium oxide nanoparticles induce ileum physical barrier dysfunction via Th1/Th2 imbalance15
Clofibrate, a PPAR‐α agonist, abrogates sodium fluoride‐induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba‐1/anti‐calbindin signaling pathways15
LncRNA SNHG14 contributes to proinflammatory cytokine production in rheumatoid arthritis via the regulation of the miR‐17‐5p/MINK1‐JNK pathway15
Benzo[a]pyrene exposure and overcrowding stress impacts anxiety‐like behavior and impairs learning and memory in adult zebrafish, Danio rerio15
Long noncodingRNA MCF2L‐AS1promotes the cancer stem cell‐like traits in non‐small cell lung cancer cells through regulatingmiR‐873‐5p level15
MiR‐186‐5p suppresses cell migration, invasion, and epithelial mesenchymal transition in bladder cancer by targeting RAB27A/B15
Inhibition of ALKBH5‐mediated m6A modification of PPARG mRNA alleviates H/R‐induced oxidative stress and apoptosis in placenta trophoblast15
Perfluorooctane sulfonate‐induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol15
Reactive oxygen species regulate miR‐17‐5p expression via DNA methylation in paraquat‐induced nerve cell damage15
Combined lead and zinc oxide‐nanoparticles induced thyroid toxicity through 8‐OHdG oxidative stress‐mediated inflammation, apoptosis, and Nrf2 activation in rats14
Toxicity of thioacetamide and protective effects of quercetin in zebrafish (Danio rerio) larvae14
Mitigation of radiation‐induced hematopoietic system injury by melatonin14
High‐fat diet exacerbates lead‐induced blood–brain barrier disruption by disrupting tight junction integrity14
Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine14
Silica nanoparticles induce mitochondrial pathway‐dependent apoptosis by activating unfolded protein response in human neuroblastoma cells14
Hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish following sub‐chronic exposure to BDE‐47 and BDE‐15314
Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF314
Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells14
Suppression of bisphenol A‐induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio)14
Hsa_circ_0001073 targets miR‐626/LIFR axis to inhibit lung cancer progression14
Proteomics analysis of zebrafish larvae exposed to 3,4‐dichloroaniline using the fish embryo acute toxicity test14
Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS/MAPK/HIF1α pathway14
The estrogenic proliferative effects of two alkylphenols and a preliminary mechanism exploration in MCF‐7 breast cancer cells14
Delphinidin modulates JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells13
DLX6‐AS1 accelerates cell proliferation through regulating miR‐497‐5p/SNCG pathway in prostate cancer13
Long noncoding RNA FAM66C promotes tumor progression and glycolysis in intrahepatic cholangiocarcinoma by regulating hsa‐miR‐23b‐3p/KCND2 axis13
The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways13
Kaempferol inhibits the cell migration of human hepatocellular carcinoma cells by suppressing MMP‐9 and Akt signaling13
Potential chemotherapeutic effect of betalain against human non‐small cell lung cancer through PI3K/Akt/mTOR signaling pathway13
Cytotoxicity, genotoxicity, oxidative stress, and apoptosis in HepG2 cells induced by the imidazole ionic liquid 1‐dodecyl‐3‐methylimidazolium chloride13
Total flavonoids of Epimedium ameliorates testicular damage in streptozotocin‐induced diabetic rats by suppressing inflammation and oxidative stress13
Protective effects of valproic acid on 6‐hydroxydopamine‐induced neuroinjury13
Pomegranate extract inhibits migration and invasion of oral cancer cells by downregulating matrix metalloproteinase‐2/9 and epithelial‐mesenchymal transition13
ROCK inhibitor attenuates carbon blacks‐induced pulmonary fibrosis in mice via Rho/ROCK/NF‐kappa B pathway13
Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H2O2‐ and UVB‐induced aging in human dermal fibrob13
Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib‐resistant melanoma cells by downregulating the EGFR signaling pathway13
The toxic effects of titanium dioxide nanoparticles on plasma glucose metabolism are more severe in developing mice than in adult mice13
DNA damage, immunotoxicity, and neurotoxicity induced by deltamethrin on the freshwater crayfish, Procambarus clarkii13
Toxic effects of hydrogen sulfide donor NaHS induced liver apoptosis is regulated by complex IV subunits and reactive oxygen species generation in rats13
Long noncoding RNA MACC1‐AS1 promotes the stemness of nonsmall cell lung cancer cells through promoting UPF1‐mediated destabilization of LATS1/213
Poly(ADP‐ribose) glycohydrolase silencing‐mediated H2B expression inhibits benzo(a)pyrene‐induced carcinogenesis13
Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor‐positive breast cancer therapy: An in vitro study12
Protection of melatonin against long‐term radon exposure‐caused lung injury12
Integrated analysis of multi‐omics data on epigenetic changes caused by combined exposure to environmental hazards12
Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide‐induced model of steatohepatitis‐associated hepatocarcinogenesis12
Fucoxanthin treatment inhibits nasopharyngeal carcinoma cell proliferation through induction of autophagy mechanism12
Effects of 2,4‐dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy‐related proteins as well as the protective effect of Lycium barbarum polysaccharide in12
Arecoline induces heart injure via Fas/Fas ligand apoptotic pathway in heart of Sprague–Dawley rat12
Comparative assessment of neurotoxicity impacts induced by alkyl tri‐n‐butyl phosphate and aromatic tricresyl phosphate in PC12 cells12
Oxidative stress accelerates synaptic glutamate dyshomeostasis and NMDARs disorder during methylmercury‐induced neuronal apoptosis in rat cerebral cortex12
Pitavastatin and metformin synergistically activate apoptosis and autophagy in pancreatic cancer cells12
Protective effect of hesperidin against N,N′‐dimethylhydrazine induced oxidative stress, inflammation, and apoptotic response in the colon of Wistar rats12
HBCD, TBECH, and BTBPE exhibit cytotoxic effects in human vascular endothelial cells by regulating mitochondria function and ROS production12
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability12
Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism12
Ochratoxin A induces human kidney tubular epithelial cell apoptosis through regulating lipid raft/PTEN/AKT signaling pathway12
Anti‐ulcerative effects of wogonin on ulcerative colitis induced by dextran sulfate sodium via Nrf2/TLR4/NF‐κB signaling pathway in BALB/c mice12
PM2.5 exposure‐induced ferroptosis in neuronal cells via inhibiting ERK/CREB pathway11
Triclosan regulates the Nrf2/HO‐1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons11
Glyburide attenuates B(a)p and LPS‐induced inflammation‐related lung tumorigenesis in mice11
Syringin alleviates ovalbumin‐induced lung inflammation in BALB/c mice asthma model via NF‐κB signaling pathway11
Tetrabromoethylcyclohexane (TBECH) exhibits immunotoxicity in murine macrophages11
Single and combined effects of carbamazepine and copper on nervous and antioxidant systems of zebrafish (Danio rerio)11
LncRNA PVT1 contributes to invasion and doxorubicin resistance of bladder cancer cells through promoting MDM2 expression and AURKB‐mediated p53 ubiquitination11
LncRNA PSMA3‐AS1 promotes cell proliferation, migration, and invasion in ovarian cancer by activating the PI3K/Akt pathway via the miR‐378a‐3p/GALNT3 axis11
Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF‐κB‐mediated anti‐apoptotic potential in glioblastoma11
Silencing of miR‐497‐5p inhibits cell apoptosis and promotes autophagy in Parkinson's disease by upregulation of FGF211
Cytotoxic and apoptotic effects of ethanolic propolis extract on C6 glioma cells11
Luteolin mitigates potassium dichromate‐induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim‐1/Nrf2 signaling pathways11
Polystyrene microplastic particles induce autophagic cell death in BEAS‐2B human bronchial epithelial cells11
The therapeutic effects of Prunella vulgaris against fluoride‐induced oxidative damage by using the metabolomics method11
LncRNA NCK1‐AS1 exerts oncogenic property in gastric cancer by targeting the miR‐22‐3p/BCL9 axis to activate the Wnt/β‐catenin signaling11
Resveratrol reduces DRP1‐mediated mitochondrial dysfunction via the SIRT1‐PGC1α signaling pathway in manganese‐induced nerve damage in mice11
RNA‐binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3′UTR with miR‐92a‐3p11
Protective effects of ethyl acetate extract from Shorea roxburghii against diabetes induced testicular damage in rats11
Sorafenib reduces steatosis‐induced fibrogenesis in a human 3D co‐culture model of non‐alcoholic fatty liver disease10
Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis10
The antagonistic effect of melatonin on TBBPA‐induced apoptosis and necroptosis via PTEN/PI3K/AKT signaling pathway in swine testis cells10
Nano nickel oxide promotes epithelial‐mesenchymal transition through transforming growth factor β1/smads signaling pathway in A549 cells10
Effect of resveratrol on the inflammatory status and oxidative stress in thymus gland and spleen of sulfoxaflor‐treated rats10
MiR‐20a inhibits the progression of human arthritis fibroblast‐like synoviocytes and inflammatory factor expression by targeting ADAM1010
Thiamethoxam‐induced oxidative stress, lipid peroxidation, and disturbance of steroidogenic genes in male rats: Palliative role of Saussurea lappa and Silybum marianum10
Protective effect of nimbolide against streptozotocin induced gestational diabetes mellitus in rats via alteration of inflammatory reaction, oxidative stress, and gut microbiota10
Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR‐3529‐5p/RNASEH2A axis under the competitive endogen10
miR‐146a promotes proliferation, invasion, and epithelial‐to‐mesenchymal transition in oral squamous carcinoma cells10
Luteolin‐7‐O‐glucoside inhibits cell proliferation and modulates apoptosis through the AKT signaling pathway in human nasopharyngeal carcinoma10
Melatonin improves bisphenol A‐induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 MAPK signaling pathway in FLK‐BLV cells10
Inhibition of NCAPG expression inactivates the Wnt/β‐catenin signal to suppresses endometrial cancer cell growth in vitro10
SH3PXD2A‐AS1/miR‐330‐5p/UBA2 ceRNA network mediates the progression of colorectal cancer through regulating the activity of the Wnt/β‐catenin signaling pathway10
Exploring the impact of a naturally occurring sapogenin diosgenin on underlying mechanisms of Ca2+ movement and cytotoxicity in human prostate cancer cells10
Low concentration triphenyl phosphate fuels proliferation and migration of hepatocellular carcinoma cells10
Long non‐coding RNA NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via miR‐577/COBLL1 axis10
Poria cocos (Fuling) targets TGFβ/Smad7 associated collagen accumulation and enhances Nrf2‐antioxidant mechanism to exert anti‐skin aging effects in human dermal fibroblasts10
Corynoline protects lipopolysaccharide‐induced mastitis through regulating AKT/GSK3β/Nrf2 signaling pathway10
MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell‐cycle checkpoint gene CCNB110
Scutellarin alleviates cerebral ischemia/reperfusion by suppressing oxidative stress and inflammatory responses via MAPK/NF‐κB pathways in rats10
Influence of silica nanoparticles on cadmium‐induced cytotoxicity, oxidative stress, and apoptosis in human liver HepG2 cells10
Butein induces cellular senescence through reactive oxygen species‐mediated p53 activation in osteosarcoma U‐2 OS cells10
Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines10
Dieckol alleviates dextran sulfate sodium‐induced colitis via inhibition of inflammatory pathway and activation of Nrf2/HO‐1 signaling pathway10
Effects of lead exposure on the activation of microglia in mice fed with high‐fat diets10
Propolis nanoparticles modulate the inflammatory and apoptotic pathways in carbon tetrachloride‐induced liver fibrosis and nephropathy in rats10
α‐Lipoic acid protects against microcystin‐LR induced hepatotoxicity through regeneration of glutathione via activation of Nrf210
LINC00473 downregulation facilitates trophoblast cell migration and invasion via the miR‐15a‐5p/LITAF axis in pre‐eclampsia9
Caffeic acid phenethyl ester induces radiosensitization via inhibition of DNA damage repair in androgen‐independent prostate cancer cells9
Ursolic acid reduces Adriamycin resistance of human ovarian cancer cells through promoting the HuR translocation from cytoplasm to nucleus9
Puerarin alleviates cadmium‐induced oxidative damage to bone by reducing autophagy in rats9
Antimycin A shows selective antiproliferation to oral cancer cells by oxidative stress‐mediated apoptosis and DNA damage9
circ_0089153 exacerbates breast cancer cells proliferation and metastasis via sponging miR‐2467‐3p/E2F69
Glyburide attenuates ozone‐induced pulmonary inflammation and injury by blocking the NLRP3 inflammasome9
Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma9
A macrolide from Streptomyces sp. modulates apoptosis and autophagy through Mcl‐1 downregulation in human breast cancer cells9
Estrogen receptor‐α36 is involved in diallyl sulfide‐induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells9
Circ‐SNAP47 (hsa_circ_0016760) and miR‐625‐5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP‐tolerant NSCLC cells via ceRNA pathway9
2,4‐dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body‐induced autophagy disorder in microglia and the protective effect of Lycium barbarum polys9
Toxicogenicity and mechanistic pathways of aflatoxinB1induced renal injury9
Inhibition of the notch signaling pathway overcomes resistance of cervical cancer cells to paclitaxel through retardation of the epithelial–mesenchymal transition process9
circ_0008797 attenuates non‐small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR‐301a‐3p/SOCS29
Acute iron oxide nanoparticles exposure induced murine eosinophilic airway inflammation via TLR2 and TLR4 signaling9
Thymoquinone loaded calcium alginate and polyvinyl alcohol carrier inhibits the 7,12‐dimethylbenz[a]anthracene‐induced hamster oral cancer via the down‐regulation of PI3K/AKT/9
Long non‐coding RNA DUXAP9 promotes hepatocellular carcinoma cell stemness via directly interacting with sox99
Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK‐mediated signaling pathway9
Shh‐Yap signaling controls hepatic ductular reactions in CCl4‐induced liver injury9
The role of H3K9me2‐regulated base excision repair genes in the repair of DNA damage induced by arsenic in HaCaT cells and the effects of Ginkgo biloba9
Seven traditional Chinese herbal extracts fermented by Lactobacillus rhamnosus provide anti‐pigmentation effects by regulating the CREB/MITF/tyrosina9
Insight into the mechanism of aspartame‐induced toxicity in male reproductive system following long‐term consumption in mice model9
Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di‐N‐butyl‐phthalate9
circZFR regulates thyroid cancer progression by the miR‐16/MAPK1 axis9
DNA damage and cell apoptosis induced by fungicide difenoconazole in mouse mononuclear macrophage RAW264.79
LncRNA LINC00115 facilitates lung cancer progression through miR‐607/ITGB1 pathway9
Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics9
Sub‐chronic exposure to ammonia inhibits the growth of juvenile Wuchang bream (Megalobrama amblycephala) mainly by downregulation of growth hormone/insulin‐like growth factor axis9
Microcrystalline silica particles induce inflammatory response via pyroptosis in primary human respiratory epithelial cells9
Selenium protects against cadmium‐induced cardiac injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling9
Shikonin ameliorates injury and inflammatory response of LPS‐stimulated WI‐38 cells via modulating the miR‐489‐3p/MAP2K1 axis9
Downregulation of estrogen receptor‐α36 expression attenuates metastasis of hepatocellular carcinoma cells9
Low concentrations of 17β‐estradiol exacerbate tamoxifen resistance in breast cancer treatment through membrane estrogen receptor‐mediated signaling pathways9
Prostate cancer‐secreted CCN3 uses the GSK3β and β‐catenin pathways to enhance osteogenic factor levels in osteoblasts8
In vivo hepatoprotective effect of Morinda elliptica stem extract against liver fibrosis induced by thioacetamide8
Fucoxanthin decreases lipopolysaccharide‐induced acute lung injury through the inhibition of RhoA activation and the NF‐κB pathway8
Mechanisms of acrolein induces toxicity in human umbilical vein endothelial cells: Oxidative stress, DNA damage response, and apoptosis8
LINC01234 aggravates cell growth and migration of triple‐negative breast cancer by activating the Wnt pathway8
Rutin‐protected BisGMA‐induced cytotoxicity, genotoxicity, and apoptosis in macrophages through the reduction of the mitochondrial apoptotic pathway and induction of antioxidant enzymes8
Can marine‐derived fungus Neosartorya siamensis KUFA 0017 extract and its secondary metabolites enhance antitumor activity of doxorubicin? An in vitro survey unveils interactions against lung c8
TRIB3 confers glioma cell stemness via interacting with β‐catenin8
Impact of zinc oxide nanoparticles on thioredoxin‐interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma‐irradiated rats8
The crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress promoted ATF4‐mediated mitophagy induced by hexavalent chromium8
Sinapic acid mitigates methotrexate‐induced hepatic injuries in rats through modulation of Nrf‐2/HO‐1 signaling8
Glyphosate‐based herbicides induces autophagy in IPEC‐J2 cells and the intervention of N‐acetylcysteine8
ROS generation is involved in titanium dioxide nanoparticle‐induced AP‐1 activation through p38 MAPK and ERK pathways in JB6 cells8
Dihydromyricetin inhibits cancer cell migration and matrix metalloproteinases‐2 expression in human nasopharyngeal carcinoma through extracellular signal‐regulated kinase signaling pathway8
Protective effect of C‐phycocyanin and apo‐phycocyanin subunit on programmed necrosis of GC‐1 spg cells induced by H2O28
Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA‐183/135b‐FOXO1/TXNIP/NLRP3 inflammasome 8
Andrographolide mitigates cardiac apoptosis to provide cardio‐protection in high‐fat‐diet‐induced obese mice8
Galectin‐3 facilitates inflammation and apoptosis in chondrocytes through upregulation of the TLR‐4‐mediated oxidative stress pathway in TC28a2 human chondrocyte cells8
Trimetazidine improved adriamycin‐induced cardiomyopathy by downregulating TNF‐α, BAX, and VEGF immunoexpression via an antioxidant mechanism8
Aerobic exercise and eugenol supplementation ameliorated liver injury induced by chlorpyrifos via modulation acetylcholinesterase activation and antioxidant defense8
LncRNA RHPN1‐AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR‐7‐5p/EGFR/PI3K/AKT/mTOR signaling pat8
Traditional Chinese medicine formula T33 inhibits the proliferation of human colorectal cancer cells by inducing autophagy8
Shenlian extract protects against ultrafine particulate matter‐aggravated myocardial ischemic injury by inhibiting inflammation response via the activation of NLRP3 inflammasomes8
miR‐486‐3p regulates CyclinD1 and promotes fluoride‐induced osteoblast proliferation and activation8
TRIP13 exerts a cancer‐promoting role in cervical cancer by enhancing Wnt/β‐catenin signaling via ACTN48
Inhalation exposure to silver nanoparticles induces hepatic inflammation and oxidative stress, associated with altered renin‐angiotensin system signaling, in Wistar rats8
Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation8
Biochemical study on the protective effect of curcumin on acetaminophen and gamma‐irradiation induced hepatic toxicity in rats8
Activation of Nrf2/HO‐1 signaling pathway attenuates ROS‐mediated autophagy induced by silica nanoparticles in H9c2 cells8
Linseed ameliorates renal apoptosis in rat fetuses induced by single or combined exposure to diesel nanoparticles or fenitrothion by inhibiting transcriptional activation of p21/p53 and caspase‐3/9 th8
Hsp70 overexpression in Drosophila hemocytes attenuates benzene‐induced immune and developmental toxicity via regulating ROS/JNK signaling pathway8
Citral inhibits N‐nitrosodiethylamine‐induced hepatocellular carcinoma via modulation of antioxidants and xenobiotic‐metabolizing enzymes8
Uranium induces kidney cells apoptosis via reactive oxygen species generation, endoplasmic reticulum stress and inhibition of PI3K/AKT/mTOR signaling in culture8
CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR‐375/SLC7A11 axis8
Trans‐ovo permethrin exposure affects growth, brain morphology and cardiac development in quail7
Miconazole induces protective autophagy in bladder cancer cells7
Kirenol regulates the cell proliferative and inflammatory markers in DMBA‐induced oral squamous cell carcinogenesis in hamster7
Quercetin induces autophagy in myelodysplastic bone marrow including hematopoietic stem/progenitor compartment7
Per‐ and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells7
LPS‐enhanced IGF‐IIR pathway to induce H9c2 cardiomyoblast cell hypertrophy was attenuated by Carthamus tinctorius extract via IGF‐IR activation7
Dipeptide IF prevents the effects of hypertension‐induced Alzheimer's disease on long‐term memory in the cortex of spontaneously hypertensive rats7
MiRNA‐429 alleviates ketamine‐induced neurotoxicity through targeting BAG57
Dioscorea nipponica Makino suppresses TPA‐induced migration and invasion through inhibition of matrix metalloproteinase‐9 in human cervical cancer cells7
Magnesium lithospermate B supplementation improved prenatal Bisphenol A exposure‐induced metabolic abnormalities in male offspring7
Gallic acid: A promising genoprotective and hepatoprotective bioactive compound against cyclophosphamide induced toxicity in mice7
Silica dust exposure induces autophagy in alveolar macrophages through switching Beclin1 affinity from Bcl‐2 to PIK3C37
CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR‐194‐5p/Fzd6 axis and beta‐catenin signaling7
Effect of prenatal exposure to Benzo[a]pyrene on ovarian toxicity and reproductive dysfunction: Protective effect of atorvastatin in the embryonic period7
Isatidis Folium alleviates acetaminophen‐induced liver injury in mice by enhancing the endogenous antioxidant system7
Procyanidin protects human retinal pigment epithelial cells from high glucose by inhibiting autophagy7
Cadmium cytotoxicity and possible mechanisms in human trophoblast HTR‐8/SVneo cells7
Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine7
Role of N6‐methyladenosine RNA modification in the imbalanced inflammatory homeostasis of arsenic‐induced skin lesions7
Bergenin alleviates H2O2‐induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR‐γ/NF‐κB pathway7
Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells7
Long noncoding RNA LINC00184 facilitates the proliferation, metastasis, and adenine metabolism of cholangiocarcinoma via modulating hsa‐miR‐23b‐3p/ANXA2 axis7
Histopathological evaluation of the interrenal gland (adrenal homolog) of Japanese medaka (Oryzias latipes) exposed to graphene oxide7
p,p′‐Dichlorodiphenyltrichloroethane promotes aerobic glycolysis via reactive oxygen species–mediated extracellular signal‐regulated kinase/M2 isoform of pyruvate kinase (PKM2) signaling7
N‐acetylcysteine reduced the immunotoxicity effects induced in vitro by azoxystrobin and iprodione fungicides in mice7
Metformin scavenges formaldehyde and attenuates formaldehyde‐induced bovine serum albumin crosslinking and cellular DNA damage7
Long non‐coding RNA LINC00514 promotes the proliferation and invasion through the miR‐708‐5p/HOXB3 axis in cervical squamous cell carcinoma7
6,8‐Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p537
CRABP2 accelerates epithelial mesenchymal transition in serous ovarian cancer cells by promoting TRIM16 methylation via upregulating EZH2 expression7
MicroRNA‐455‐3p functions as a tumor suppressor by targeting HDAC2 to regulate cell cycle in hepatocellular carcinoma7
Chitosan attenuated the neurotoxicity‐induced titanium dioxide nanoparticles in brain of adult rats7
Effects of perfluorooctanoic acid in oxidative stress generation, DNA damage in cumulus cells, and its impact on in vitro maturation of porcine oocytes7
Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model7
The antimammary tumor effects of ethanolic extract of propolis from Adamawa region (Cameroon) are by apoptosis via reactive oxygen species‐mediated mitochondrial pathway7
LncRNA MEG3 restrained pulmonary fibrosis induced by NiO NPs via regulating hedgehog signaling pathway‐mediated autophagy7
Panax ginseng modulates oxidative stress, DNA damage, apoptosis, and inflammations induced by silicon dioxide nanoparticles in rats7
Dichloroacetate attenuates the stemness of hepatocellular carcinoma cells via promoting nucleus‐cytoplasm translocation of YAP7
ABCA8 inhibits breast cancer cell proliferation by regulating the AMP activated protein kinase/mammalian target of rapamycin signaling pathway7
Norcantharidin combined with paclitaxel induces endoplasmic reticulum stress mediated apoptotic effect in prostate cancer cells by targeting SIRT7 expression7
S1P facilitates IL‐1β production in osteoblasts via the JAK and STAT3 signaling pathways7
Ochratoxin a induces hepatic fibrosis through TGF‐β receptor I/Smad2/3 signaling pathway7
Fat1 suppresses the tumor‐initiating ability of nonsmall cell lung cancer cells by promoting Yes‐associated protein 1 nuclear‐cytoplasmic translocation7
Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite‐induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats7
Biofabricated zinc oxide nanoparticles impair cognitive function via modulating oxidative stress and acetylcholinesterase level in mice7
CircFAM64A enhances cellular processes in triple‐negative breast cancer by targeting the miR‐149‐5p/CDT1 axis7
Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR7
Resveratrol inhibits oral squamous cell carcinoma cells proliferation while promoting apoptosis through inhibition of CBX7 protein7
Nano‐selenium attenuates mitochondrial‐associated apoptosis via the PI3K/AKT pathway in nickel‐induced hepatotoxicity in vivo and in vitro7
Acylglycerol kinase promotes the stemness of nasopharyngeal carcinoma cells by promoting β‐catenin translocation to the nucleus through activating PI3K/Akt pathway7
Low concentrations of sodium arsenite induce hepatotoxicity in prepubertal male rats7