Environmental Toxicology

Papers
(The median citation count of Environmental Toxicology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-06-01 to 2024-06-01.)
ArticleCitations
PM2.5‐induced pulmonary inflammation via activating of the NLRP3/caspase‐1 signaling pathway82
The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase‐1 signaling pathway and oxidative stress in Wistar rats74
Hesperidin protects against the chlorpyrifos‐induced chronic hepato‐renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up‐regulation of PARP‐1/V53
Investigation of the effects of hesperidin administration on abamectin‐induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, autophagy, a50
Polystyrene nanoplastics exacerbated lipopolysaccharide‐induced necroptosis and inflammation via the ROS/MAPK pathway in mice spleen44
Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice43
Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis41
Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of ze41
CircKDM4C upregulates P53 by sponging hsa‐let‐7b‐5p to induce ferroptosis in acute myeloid leukemia41
Cadmium induces ferroptosis and apoptosis by modulating miR‐34a‐5p/Sirt1axis in PC12 cells41
An assessment of serum‐dependent impacts on intracellular accumulation and genomic response of per‐ and polyfluoroalkyl substances in a placental trophoblast model39
Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes36
Curcumin functions as an anti‐inflammatory and antioxidant agent on arsenic‐induced hepatic and kidney injury by inhibiting MAPKs/NF‐κB and activating Nrf2 36
ROS‐mediated PERK‐eIF2α‐ATF4 pathway plays an important role in arsenite‐induced L‐02 cells apoptosis via regulating CHOP‐DR5 signaling35
Exosomal lncRNA HMMR‐AS1 mediates macrophage polarization through miR‐147a/ARID3A axis under hypoxia and affects the progression of hepatocellular carcinoma35
CircRNA circ_POLA2 promotes lung cancer cell stemness via regulating the miR‐326/GNB1 axis35
Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA‐PAA nano‐encapsulation on PANC‐1 pancreatic cancer cell line35
Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM2.5 in mice35
Review on the ecotoxicological impacts of plastic pollution on the freshwater invertebrate Daphnia33
Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis33
Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice33
Developmental toxicity induced by Cu(OH)2 nanopesticide in zebrafish embryos33
Melatonin increases the anticancer potential of doxorubicin in Caco‐2 colorectal cancer cells31
Deltamethrin induces apoptosis in cerebrum neurons of quail via promoting endoplasmic reticulum stress and mitochondrial dysfunction31
Di‐(2‐ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice30
PM2.5 induces endothelial dysfunction via activating NLRP3 inflammasome30
A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2‐positive breast cancer through regulating ferroptosis30
An ecofriendly synthesized gold nanoparticles induces cytotoxicity via apoptosis inHepG2cells29
Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway28
Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS/MAPK/HIF1α pathway28
LncRNA MEG3 mediates nickel oxide nanoparticles‐induced pulmonary fibrosis via suppressing TGF‐β1 expression and epithelial‐mesenchymal transition process27
Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway27
Silica dust exposure induces pulmonary fibrosis through autophagy signaling27
Overexpression of HIF‐1α enhances the protective effect of mitophagy on steroid‐induced osteocytes apoptosis27
Lagerstroemia speciosa (L.) Pers. triggers oxidative stress mediated apoptosis via intrinsic mitochondrial pathway in HepG2 cells26
Lithium intoxication induced pyroptosis via ROS/NF‐κB/NLRP3 inflammasome regulatory networks in kidney of mice26
Nootkatone improves anxiety‐ and depression‐like behavior by targeting hyperammonemia‐induced oxidative stress in D‐galactosamine model of liver injury26
Imbalanced inflammatory response in subchronic arsenic‐induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell–cel26
The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells26
Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling25
Environmental relevant concentrations of triclosan affected developmental toxicity, oxidative stress, and apoptosis in zebrafish embryos25
Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions25
Serum cadmium positively correlates with inflammatory cytokines in patients with chronic obstructive pulmonary disease24
Bisphenol A induced apoptosis via oxidative stress generation involved Nrf2/HO‐1 pathway and mitochondrial dependent pathways in human retinal pigment epithelium (24
Cardioprotective potential of amygdalin against angiotensin II induced cardiac hypertrophy, oxidative stress and inflammatory responses through modulation of Nrf2 and NF‐κB activ24
Verbascoside inhibits the epithelial‐mesenchymal transition of prostate cancer cells through high‐mobility group box 1/receptor for advanced glycation end‐products/TGF‐β pathway24
Kaempferol inhibits the cell migration of human hepatocellular carcinoma cells by suppressing MMP‐9 and Akt signaling23
Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K/Akt pathway22
Curcumin suppresses the stemness of non‐small cell lung cancer cells via promoting the nuclear‐cytoplasm translocation of TAZ22
Polystyrene microplastic particles induce autophagic cell death in BEAS‐2B human bronchial epithelial cells22
Borneol protects against cerulein‐induced oxidative stress and inflammation in acute pancreatitis mice model21
Benzo[a]pyrene exposure and overcrowding stress impacts anxiety‐like behavior and impairs learning and memory in adult zebrafish, Danio rerio21
Calycosin alleviates H2O2‐induced astrocyte injury by restricting oxidative stress through the Akt/Nrf2/HO‐1 signaling pathway20
Nigella sativa oil protects against emamectin benzoate‐Induced neurotoxicity in rats20
Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK20
Diosmetin alleviates cerebral ischemia‐reperfusion injury through Keap1‐mediated Nrf2/ARE signaling pathway activation and NLRP3 inflammasome inhibition20
Cytotoxicity of naringenin induces Bax‐mediated mitochondrial apoptosis in human lung adenocarcinoma A549 cells20
Inhibition of ALKBH5‐mediated m6A modification of PPARG mRNA alleviates H/R‐induced oxidative stress and apoptosis in placenta trophoblast20
Plumbagin protects the myocardial damage by modulating the cardiac biomarkers, antioxidants, and apoptosis signaling in the doxorubicin‐induced cardiotoxicity in rats20
Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF320
Brucine promotes apoptosis in cervical cancer cells (ME‐180) via suppression of inflammation and cell proliferation by regulating PI3K/AKT/mTOR signaling pa19
MiR‐122‐5p and miR‐326‐3p promote cadmium‐induced NRK‐52E cell apoptosis by downregulating PLD119
Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib‐resistant melanoma cells by downregulating the EGFR signaling pathway19
Melatonin ameliorates Bisphenol S induced testicular damages by modulating Nrf‐2/HO‐1 and SIRT‐1/FOXO‐1 expressions19
High‐fat diet exacerbates lead‐induced blood–brain barrier disruption by disrupting tight junction integrity19
Scutellarin alleviates cerebral ischemia/reperfusion by suppressing oxidative stress and inflammatory responses via MAPK/NF‐κB pathways in rats19
Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine18
Silencing of miR‐497‐5p inhibits cell apoptosis and promotes autophagy in Parkinson's disease by upregulation of FGF218
Potential chemotherapeutic effect of betalain against human non‐small cell lung cancer through PI3K/Akt/mTOR signaling pathway18
MiR‐186‐5p suppresses cell migration, invasion, and epithelial mesenchymal transition in bladder cancer by targeting RAB27A/B18
Long noncodingRNA MCF2L‐AS1promotes the cancer stem cell‐like traits in non‐small cell lung cancer cells through regulatingmiR‐873‐5p level18
Dual down‐regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells18
Delphinidin modulates JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells18
The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways18
Luteolin‐7‐O‐glucoside inhibits cell proliferation and modulates apoptosis through the AKT signaling pathway in human nasopharyngeal carcinoma18
Resveratrol reduces DRP1‐mediated mitochondrial dysfunction via the SIRT1‐PGC1α signaling pathway in manganese‐induced nerve damage in mice17
Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H2O2‐ and UVB‐induced aging in human dermal fibrob17
Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells17
The therapeutic effects of Prunella vulgaris against fluoride‐induced oxidative damage by using the metabolomics method17
Hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish following sub‐chronic exposure to BDE‐47 and BDE‐15317
Hsa_circ_0001073 targets miR‐626/LIFR axis to inhibit lung cancer progression17
LncRNA SNHG14 contributes to proinflammatory cytokine production in rheumatoid arthritis via the regulation of the miR‐17‐5p/MINK1‐JNK pathway17
Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis17
Perfluorooctane sulfonate‐induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol17
Inorganic arsenic‐mediated upregulation of AS3MT promotes proliferation of nonsmall cell lung cancer cells by regulating cell cycle genes16
Silica nanoparticles induce mitochondrial pathway‐dependent apoptosis by activating unfolded protein response in human neuroblastoma cells16
DNA damage, immunotoxicity, and neurotoxicity induced by deltamethrin on the freshwater crayfish, Procambarus clarkii16
Comparative assessment of neurotoxicity impacts induced by alkyl tri‐n‐butyl phosphate and aromatic tricresyl phosphate in PC12 cells16
PM2.5 exposure‐induced ferroptosis in neuronal cells via inhibiting ERK/CREB pathway16
Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR16
Anti‐ulcerative effects of wogonin on ulcerative colitis induced by dextran sulfate sodium via Nrf2/TLR4/NF‐κB signaling pathway in BALB/c mice16
Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism16
LncRNA PVT1 contributes to invasion and doxorubicin resistance of bladder cancer cells through promoting MDM2 expression and AURKB‐mediated p53 ubiquitination16
Suppression of bisphenol A‐induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio)16
Toxicity of thioacetamide and protective effects of quercetin in zebrafish (Danio rerio) larvae16
Long noncoding RNA FAM66C promotes tumor progression and glycolysis in intrahepatic cholangiocarcinoma by regulating hsa‐miR‐23b‐3p/KCND2 axis16
Reactive oxygen species regulate miR‐17‐5p expression via DNA methylation in paraquat‐induced nerve cell damage16
Syringin alleviates ovalbumin‐induced lung inflammation in BALB/c mice asthma model via NF‐κB signaling pathway15
MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell‐cycle checkpoint gene CCNB115
Effects of 2,4‐dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy‐related proteins as well as the protective effect of Lycium barbarum polysaccharide in15
Arecoline induces heart injure via Fas/Fas ligand apoptotic pathway in heart of Sprague–Dawley rat15
Luteolin mitigates potassium dichromate‐induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim‐1/Nrf2 signaling pathways15
Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics15
circ_0089153 exacerbates breast cancer cells proliferation and metastasis via sponging miR‐2467‐3p/E2F615
Protection of melatonin against long‐term radon exposure‐caused lung injury15
Traditional Chinese medicine formula T33 inhibits the proliferation of human colorectal cancer cells by inducing autophagy15
Combined lead and zinc oxide‐nanoparticles induced thyroid toxicity through 8‐OHdG oxidative stress‐mediated inflammation, apoptosis, and Nrf2 activation in rats15
HBCD, TBECH, and BTBPE exhibit cytotoxic effects in human vascular endothelial cells by regulating mitochondria function and ROS production15
Toxicogenicity and mechanistic pathways of aflatoxinB1induced renal injury14
Thiamethoxam‐induced oxidative stress, lipid peroxidation, and disturbance of steroidogenic genes in male rats: Palliative role of Saussurea lappa and Silybum marianum14
Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite‐induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats14
2,4‐dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body‐induced autophagy disorder in microglia and the protective effect of Lycium barbarum polys14
ROCK inhibitor attenuates carbon blacks‐induced pulmonary fibrosis in mice via Rho/ROCK/NF‐kappa B pathway14
Ochratoxin A induces human kidney tubular epithelial cell apoptosis through regulating lipid raft/PTEN/AKT signaling pathway14
Selenium protects against cadmium‐induced cardiac injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling14
Protective effect of nimbolide against streptozotocin induced gestational diabetes mellitus in rats via alteration of inflammatory reaction, oxidative stress, and gut microbiota14
Single and combined effects of carbamazepine and copper on nervous and antioxidant systems of zebrafish (Danio rerio)14
Pitavastatin and metformin synergistically activate apoptosis and autophagy in pancreatic cancer cells14
Triclosan regulates the Nrf2/HO‐1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons14
Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor‐positive breast cancer therapy: An in vitro study14
Integrated analysis of multi‐omics data on epigenetic changes caused by combined exposure to environmental hazards14
Poly(ADP‐ribose) glycohydrolase silencing‐mediated H2B expression inhibits benzo(a)pyrene‐induced carcinogenesis14
Antimycin A shows selective antiproliferation to oral cancer cells by oxidative stress‐mediated apoptosis and DNA damage13
Dieckol alleviates dextran sulfate sodium‐induced colitis via inhibition of inflammatory pathway and activation of Nrf2/HO‐1 signaling pathway13
Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF‐κB‐mediated anti‐apoptotic potential in glioblastoma13
CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR‐431/SLC7A11 axis13
LINC01234 aggravates cell growth and migration of triple‐negative breast cancer by activating the Wnt pathway13
DLX6‐AS1 accelerates cell proliferation through regulating miR‐497‐5p/SNCG pathway in prostate cancer13
Sub‐chronic exposure to ammonia inhibits the growth of juvenile Wuchang bream (Megalobrama amblycephala) mainly by downregulation of growth hormone/insulin‐like growth factor axis13
Effects of lead exposure on the activation of microglia in mice fed with high‐fat diets13
LINC00473 downregulation facilitates trophoblast cell migration and invasion via the miR‐15a‐5p/LITAF axis in pre‐eclampsia13
Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving kinematics of sperm, and blunting the downreg13
Protective effect of hesperidin against N,N′‐dimethylhydrazine induced oxidative stress, inflammation, and apoptotic response in the colon of Wistar rats13
Hsp70 overexpression in Drosophila hemocytes attenuates benzene‐induced immune and developmental toxicity via regulating ROS/JNK signaling pathway13
Sorafenib reduces steatosis‐induced fibrogenesis in a human 3D co‐culture model of non‐alcoholic fatty liver disease13
Nano nickel oxide promotes epithelial‐mesenchymal transition through transforming growth factor β1/smads signaling pathway in A549 cells13
Mechanisms of acrolein induces toxicity in human umbilical vein endothelial cells: Oxidative stress, DNA damage response, and apoptosis12
Low concentration triphenyl phosphate fuels proliferation and migration of hepatocellular carcinoma cells12
LncRNA PSMA3‐AS1 promotes cell proliferation, migration, and invasion in ovarian cancer by activating the PI3K/Akt pathway via the miR‐378a‐3p/GALNT3 axis12
Glyburide attenuates B(a)p and LPS‐induced inflammation‐related lung tumorigenesis in mice12
hUC‐MSCs exosomal miR‐451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF‐PI3K‐AKT signaling pathway12
Carvacrol protects against λ‐Cyhalothrin‐induced hepatotoxicity and nephrotoxicity by modulating oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy12
Seven traditional Chinese herbal extracts fermented by Lactobacillus rhamnosus provide anti‐pigmentation effects by regulating the CREB/MITF/tyrosina12
TRIP13 exerts a cancer‐promoting role in cervical cancer by enhancing Wnt/β‐catenin signaling via ACTN412
Protective effects of ethyl acetate extract from Shorea roxburghii against diabetes induced testicular damage in rats12
The antagonistic effect of melatonin on TBBPA‐induced apoptosis and necroptosis via PTEN/PI3K/AKT signaling pathway in swine testis cells12
LncRNA MEG3 restrained pulmonary fibrosis induced by NiO NPs via regulating hedgehog signaling pathway‐mediated autophagy12
Long non‐coding RNA DUXAP9 promotes hepatocellular carcinoma cell stemness via directly interacting with sox912
In vitro antimetastatic activity of Momordica balsamina crude acetone extract in HT‐29 human colon cancer cells12
Long non‐coding RNA NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via miR‐577/COBLL1 axis12
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability12
Circ‐SNAP47 (hsa_circ_0016760) and miR‐625‐5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP‐tolerant NSCLC cells via ceRNA pathway12
Corynoline protects lipopolysaccharide‐induced mastitis through regulating AKT/GSK3β/Nrf2 signaling pathway12
Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di‐N‐butyl‐phthalate12
RNA‐binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3′UTR with miR‐92a‐3p12
Inhibition of NCAPG expression inactivates the Wnt/β‐catenin signal to suppresses endometrial cancer cell growth in vitro12
Prognostic impact of lactylation‐associated gene modifications in clear cell renal cell carcinoma: Insights into molecular landscape and therapeutic opportunities12
Per‐ and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells12
LncRNA NCK1‐AS1 exerts oncogenic property in gastric cancer by targeting the miR‐22‐3p/BCL9 axis to activate the Wnt/β‐catenin signaling12
LncRNA RHPN1‐AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR‐7‐5p/EGFR/PI3K/AKT/mTOR signaling pat12
Chitosan attenuated the neurotoxicity‐induced titanium dioxide nanoparticles in brain of adult rats12
CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR‐194‐5p/Fzd6 axis and beta‐catenin signaling12
CRABP2 accelerates epithelial mesenchymal transition in serous ovarian cancer cells by promoting TRIM16 methylation via upregulating EZH2 expression12
ROS generation is involved in titanium dioxide nanoparticle‐induced AP‐1 activation through p38 MAPK and ERK pathways in JB6 cells12
CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR‐375/SLC7A11 axis11
Puerarin alleviates cadmium‐induced oxidative damage to bone by reducing autophagy in rats11
Adolescent cadmium exposure impairs cognition and hippocampal neurogenesis in C57BL/6 mice11
ABCA8 inhibits breast cancer cell proliferation by regulating the AMP activated protein kinase/mammalian target of rapamycin signaling pathway11
Surfactin induces ER stress‐mediated apoptosis via IRE1‐ASK1‐JNK signaling in human osteosarcoma11
The crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress promoted ATF4‐mediated mitophagy induced by hexavalent chromium11
Uranium induces kidney cells apoptosis via reactive oxygen species generation, endoplasmic reticulum stress and inhibition of PI3K/AKT/mTOR signaling in culture11
Sinapic acid mitigates methotrexate‐induced hepatic injuries in rats through modulation of Nrf‐2/HO‐1 signaling11
Melatonin improves bisphenol A‐induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 MAPK signaling pathway in FLK‐BLV cells11
Miconazole induces protective autophagy in bladder cancer cells11
SH3PXD2A‐AS1/miR‐330‐5p/UBA2 ceRNA network mediates the progression of colorectal cancer through regulating the activity of the Wnt/β‐catenin signaling pathway11
A macrolide from Streptomyces sp. modulates apoptosis and autophagy through Mcl‐1 downregulation in human breast cancer cells11
Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR‐3529‐5p/RNASEH2A axis under the competitive endogen11
Estrogen receptor‐α36 is involved in diallyl sulfide‐induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells11
Poria cocos (Fuling) targets TGFβ/Smad7 associated collagen accumulation and enhances Nrf2‐antioxidant mechanism to exert anti‐skin aging effects in human dermal fibroblasts11
Butein induces cellular senescence through reactive oxygen species‐mediated p53 activation in osteosarcoma U‐2 OS cells11
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis11
Bergenin alleviates H2O2‐induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR‐γ/NF‐κB pathway11
Histopathological evaluation of the interrenal gland (adrenal homolog) of Japanese medaka (Oryzias latipes) exposed to graphene oxide11
Low concentrations of 17β‐estradiol exacerbate tamoxifen resistance in breast cancer treatment through membrane estrogen receptor‐mediated signaling pathways11
Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model11
Protective effect of C‐phycocyanin and apo‐phycocyanin subunit on programmed necrosis of GC‐1 spg cells induced by H2O211
Ursolic acid reduces Adriamycin resistance of human ovarian cancer cells through promoting the HuR translocation from cytoplasm to nucleus10
Rutin‐protected BisGMA‐induced cytotoxicity, genotoxicity, and apoptosis in macrophages through the reduction of the mitochondrial apoptotic pathway and induction of antioxidant enzymes10
Thymoquinone loaded calcium alginate and polyvinyl alcohol carrier inhibits the 7,12‐dimethylbenz[a]anthracene‐induced hamster oral cancer via the down‐regulation of PI3K/AKT/10
Linseed ameliorates renal apoptosis in rat fetuses induced by single or combined exposure to diesel nanoparticles or fenitrothion by inhibiting transcriptional activation of p21/p53 and caspase‐3/9 th10
Propolis nanoparticles modulate the inflammatory and apoptotic pathways in carbon tetrachloride‐induced liver fibrosis and nephropathy in rats10
Shh‐Yap signaling controls hepatic ductular reactions in CCl4‐induced liver injury10
The role of H3K9me2‐regulated base excision repair genes in the repair of DNA damage induced by arsenic in HaCaT cells and the effects of Ginkgo biloba10
Exposure to neonicotinoids and serum testosterone in men, women, and children10
Glyphosate‐based herbicides induces autophagy in IPEC‐J2 cells and the intervention of N‐acetylcysteine10
Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation10
DNA damage and cell apoptosis induced by fungicide difenoconazole in mouse mononuclear macrophage RAW264.710
circZFR regulates thyroid cancer progression by the miR‐16/MAPK1 axis10
circ_0008797 attenuates non‐small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR‐301a‐3p/SOCS210
Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA‐183/135b‐FOXO1/TXNIP/NLRP3 inflammasome 10
Naringin against doxorubicin‐induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up‐regulation of SIRT110
Microcrystalline silica particles induce inflammatory response via pyroptosis in primary human respiratory epithelial cells10
Shikonin ameliorates injury and inflammatory response of LPS‐stimulated WI‐38 cells via modulating the miR‐489‐3p/MAP2K1 axis10
Gallic acid: A promising genoprotective and hepatoprotective bioactive compound against cyclophosphamide induced toxicity in mice10
MiR‐1246 is responsible for lung cancer cells‐derived exosomes‐mediated promoting effects on lung cancer stemness via targeting TRIM1710
Nano‐selenium attenuates mitochondrial‐associated apoptosis via the PI3K/AKT pathway in nickel‐induced hepatotoxicity in vivo and in vitro10
Inhibition of the notch signaling pathway overcomes resistance of cervical cancer cells to paclitaxel through retardation of the epithelial–mesenchymal transition process10
Effects of naringin on oxidative stress, inflammation, some reproductive parameters, and apoptosis in acrylamide‐induced testis toxicity in rat10
Cadmium modulates steatosis, fibrosis, and oncogenic signaling in liver cancer cells by activating notch and AKT/mTOR pathways10
Fat1 suppresses the tumor‐initiating ability of nonsmall cell lung cancer cells by promoting Yes‐associated protein 1 nuclear‐cytoplasmic translocation10
LncRNA LINC00115 facilitates lung cancer progression through miR‐607/ITGB1 pathway10
Effect of resveratrol on the inflammatory status and oxidative stress in thymus gland and spleen of sulfoxaflor‐treated rats10
Adverse effects of chronic ammonia stress on juvenile oriental river prawn (Macrobrachium nipponense) and alteration of glucose and ammonia metabolism10
N‐acetylcysteine reduced the immunotoxicity effects induced in vitro by azoxystrobin and iprodione fungicides in mice10
Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma10
Insight into the mechanism of aspartame‐induced toxicity in male reproductive system following long‐term consumption in mice model10
Borax regulates iron chaperone‐ and autophagy‐mediated ferroptosis pathway in glioblastoma cells10
β‐Amyrin ameliorates diabetic nephropathy in mice and regulates the miR‐181b‐5p/HMGB2 axis in high glucose‐stimulated HK‐2 cells10
Prostate cancer‐secreted CCN3 uses the GSK3β and β‐catenin pathways to enhance osteogenic factor levels in osteoblasts10
Dihydromyricetin inhibits cancer cell migration and matrix metalloproteinases‐2 expression in human nasopharyngeal carcinoma through extracellular signal‐regulated kinase signaling pathway10
Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells9
Fenofibrate inhibits hypoxia‐inducible factor‐1 alpha and carbonic anhydrase expression through activation of AMP‐activated protein kinase/HO‐1/Sirt1 pathway in glioblastoma cells9
Trimetazidine improved adriamycin‐induced cardiomyopathy by downregulating TNF‐α, BAX, and VEGF immunoexpression via an antioxidant mechanism9
DNA damage induced by cylindrospermopsin on different tissues of the biomonitor fish Poecilia reticulata9
Naringin alleviates acetaminophen‐induced acute liver injury by activating Nrf2 via CHAC2 upregulation9
Long non‐coding RNA LINC00514 promotes the proliferation and invasion through the miR‐708‐5p/HOXB3 axis in cervical squamous cell carcinoma9
Downregulation of estrogen receptor‐α36 expression attenuates metastasis of hepatocellular carcinoma cells9
A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR‐1 mediated mitochondrial dysfunction and apoptosis9
Caffeic acid phenethyl ester induces radiosensitization via inhibition of DNA damage repair in androgen‐independent prostate cancer cells9
Coordinating single‐cell and bulk RNA‐seq in deciphering the intratumoral immune landscape and prognostic stratification of prostate cancer patients9
Dichloroacetate attenuates the stemness of hepatocellular carcinoma cells via promoting nucleus‐cytoplasm translocation of YAP9
Parental PM2.5 exposure changes Th17/Treg cells in offspring, is associated with the elevation of blood pressure9
Long noncoding RNA ST8SIA6‐AS1 promotes cell proliferation and metastasis in triple‐negative breast cancer by targeting miR‐145‐5p/CDCA3 to inactivate the p53/p21 sign9
Long noncoding RNA OIP5‐AS1 promotes the stemness of lung cancer cells through enhancing Oct4 mRNA stability9
T‐2 toxin‐induced femur lesion is accompanied by autophagy and apoptosis associated with Wnt/β‐catenin signaling in mice9
Dioscorea nipponica Makino suppresses TPA‐induced migration and invasion through inhibition of matrix metalloproteinase‐9 in human cervical cancer cells9
Compound essential oils relieve oxidative stress caused by PM2.5 exposure by inhibiting autophagy through the AMPK/mTOR pathway9
SIRT1/mTOR pathway‐mediated autophagy dysregulation promotes Pb‐induced hepatic lipid accumulation in HepG2 cells9
Fucoxanthin decreases lipopolysaccharide‐induced acute lung injury through the inhibition of RhoA activation and the NF‐κB pathway9
GPX4 utilization by selenium is required to alleviate cadmium‐induced ferroptosis and pyroptosis in sheep kidney9
Activation of Nrf2/HO‐1 signaling pathway attenuates ROS‐mediated autophagy induced by silica nanoparticles in H9c2 cells9
Ginsenoside Rg1 suppresses paraquat‐induced epithelial cell senescence by enhancing autophagy in an ATG12‐dependent manner9
Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation9
Galectin‐3 facilitates inflammation and apoptosis in chondrocytes through upregulation of the TLR‐4‐mediated oxidative stress pathway in TC28a2 human chondrocyte cells9
CircFAM64A enhances cellular processes in triple‐negative breast cancer by targeting the miR‐149‐5p/CDT1 axis9
Resveratrol inhibits oral squamous cell carcinoma cells proliferation while promoting apoptosis through inhibition of CBX7 protein9
Tussilagone protects acute lung injury from PM2.5 via alleviating Hif‐1α/NF‐κB‐mediated inflammatory response9
Apigenin attenuates inflammatory response in allergic rhinitis mice by inhibiting the TLR4/MyD88/NF‐κB signaling pathway9
Procyanidin protects human retinal pigment epithelial cells from high glucose by inhibiting autophagy9
Pipoxolan suppresses the inflammatory factors of NF‐κB, AP‐1, and STATs, but activates the antioxidative factor Nrf2 in LPS‐stimulated RAW 264.7 9
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