OOIR: Observatory of International Research

Papers

(The median citation count of Environmental Toxicology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase‐1 signaling pathway and oxidative stress in Wistar rats	97
Hesperidin protects against the chlorpyrifos‐induced chronic hepato‐renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up‐regulation of PARP‐1/V	60
Investigation of the effects of hesperidin administration on abamectin‐induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, autophagy, a	54
Polystyrene nanoplastics exacerbated lipopolysaccharide‐induced necroptosis and inflammation via the ROS/MAPK pathway in mice spleen	51
Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis	47
Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice	46
Cadmium induces ferroptosis and apoptosis by modulating miR‐34a‐5p/Sirt1axis in PC12 cells	45
Exosomal lncRNA HMMR‐AS1 mediates macrophage polarization through miR‐147a/ARID3A axis under hypoxia and affects the progression of hepatocellular carcinoma	44
Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of ze	44
CircKDM4C upregulates P53 by sponging hsa‐let‐7b‐5p to induce ferroptosis in acute myeloid leukemia	43
Curcumin functions as an anti‐inflammatory and antioxidant agent on arsenic‐induced hepatic and kidney injury by inhibiting MAPKs/NF‐κB and activating Nrf2	38
Di‐(2‐ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice	37
A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2‐positive breast cancer through regulating ferroptosis	37
Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA‐PAA nano‐encapsulation on PANC‐1 pancreatic cancer cell line	37
Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM₂_.5 in mice	37
Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes	37
Review on the ecotoxicological impacts of plastic pollution on the freshwater invertebrate Daphnia	36
Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS/MAPK/HIF1α pathway	35
PM2.5 induces endothelial dysfunction via activating NLRP3 inflammasome	34
Melatonin increases the anticancer potential of doxorubicin in Caco‐2 colorectal cancer cells	32
Deltamethrin induces apoptosis in cerebrum neurons of quail via promoting endoplasmic reticulum stress and mitochondrial dysfunction	31
Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway	31
Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway	30
Lithium intoxication induced pyroptosis viaROS/NF‐κB/NLRP3inflammasome regulatory networks in kidney of mice	30
Overexpression of HIF‐1α enhances the protective effect of mitophagy on steroid‐induced osteocytes apoptosis	30

Bisphenol A induced apoptosis via oxidative stress generation involved Nrf2/HO‐1 pathway and mitochondrial dependent pathways in human retinal pigment epithelium (	30
Polystyrene microplastic particles induce autophagic cell death in BEAS‐2B human bronchial epithelial cells	30
RETRACTED: Serum cadmium positively correlates with inflammatory cytokines in patients with chronic obstructive pulmonary disease	29
Silica dust exposure induces pulmonary fibrosis through autophagy signaling	29
Imbalanced inflammatory response in subchronic arsenic‐induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell–cel	29
Nootkatone improves anxiety‐ and depression‐like behavior by targeting hyperammonemia‐induced oxidative stress in D‐galactosamine model of liver injury	28
The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells	28
LncRNA MEG3 mediates nickel oxide nanoparticles‐induced pulmonary fibrosis via suppressing TGF‐β1 expression and epithelial‐mesenchymal transition process	28
Environmental relevant concentrations of triclosan affected developmental toxicity, oxidative stress, and apoptosis in zebrafish embryos	27
Verbascoside inhibits the epithelial‐mesenchymal transition of prostate cancer cells through high‐mobility group box 1/receptor for advanced glycation end‐products/TGF‐β pathway	27
Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions	27
Kaempferol inhibits the cell migration of human hepatocellular carcinoma cells by suppressing MMP‐9 and Akt signaling	26
Cardioprotective potential of amygdalin against angiotensin II induced cardiac hypertrophy, oxidative stress and inflammatory responses through modulation of Nrf2 and NF‐κB activ	25
Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling	25
Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K/Akt pathway	24
Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR	24
Diosmetin alleviates cerebral ischemia‐reperfusion injury through Keap1‐mediated Nrf2/ARE signaling pathway activation and NLRP3 inflammasome inhibition	24
Calycosin alleviatesH₂O₂‐induced astrocyte injury by restricting oxidative stress through the Akt/Nrf2/HO‐1 signaling pathway	24
Brucine promotes apoptosis in cervical cancer cells (ME‐180) via suppression of inflammation and cell proliferation by regulating PI3K/AKT/mTOR signaling pa	24
Borneol protects against cerulein‐induced oxidative stress and inflammation in acute pancreatitis mice model	23
Dual down‐regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells	22
Curcumin suppresses the stemness of non‐small cell lung cancer cells via promoting the nuclear‐cytoplasm translocation of TAZ	22
Delphinidin modulates JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells	21
Potential chemotherapeutic effect of betalain against human non‐small cell lung cancer through PI3K/Akt/mTOR signaling pathway	21
Inhibition of ALKBH5‐mediated m⁶A modification of PPARG mRNA alleviates H/R‐induced oxidative stress and apoptosis in placenta trophoblast	21
Luteolin‐7‐O‐glucoside inhibits cell proliferation and modulates apoptosis through the AKT signaling pathway in human nasopharyngeal carcinoma	21
Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib‐resistant melanoma cells by downregulating the EGFR signaling pathway	21
Nigella sativa oil protects against emamectin benzoate‐Induced neurotoxicity in rats	21
Hsa_circ_0001073 targets miR‐626/LIFR axis to inhibit lung cancer progression	20
Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3	20
Resveratrol reduces DRP1‐mediated mitochondrial dysfunction via the SIRT1‐PGC1α signaling pathway in manganese‐induced nerve damage in mice	20
Scutellarin alleviates cerebral ischemia/reperfusion by suppressing oxidative stress and inflammatory responses via MAPK/NF‐κB pathways in rats	20
Silencing of miR‐497‐5p inhibits cell apoptosis and promotes autophagy in Parkinson's disease by upregulation of FGF2	20
Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine	19
Perfluorooctane sulfonate‐induced apoptosis in kidney cells by triggering theNOX4/ROS/JNKaxis and antagonism of cannabidiol	19
High‐fat diet exacerbates lead‐induced blood–brain barrier disruption by disrupting tight junction integrity	19
Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis	19
Suppression of bisphenol A‐induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio)	18
Per‐ and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells	18
Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H₂O₂‐ and UVB‐induced aging in human dermal fibrob	18
Toxicity of thioacetamide and protective effects of quercetin in zebrafish (Danio rerio) larvae	18
The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways	18
Luteolin mitigates potassium dichromate‐induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim‐1/Nrf2 signaling pathways	18
MiR‐186‐5p suppresses cell migration, invasion, and epithelial mesenchymal transition in bladder cancer by targeting RAB27A/B	18
Anti‐ulcerative effects of wogonin on ulcerative colitis induced by dextran sulfate sodium via Nrf2/TLR4/NF‐κB signaling pathway in BALB/c mice	18
Long noncodingRNA MCF2L‐AS1promotes the cancer stem cell‐like traits in non‐small cell lung cancer cells through regulatingmiR‐873‐5p level	18
Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism	17
PM₂_.5 exposure‐induced ferroptosis in neuronal cells via inhibiting ERK/CREB pathway	17
Silica nanoparticles induce mitochondrial pathway‐dependent apoptosis by activating unfolded protein response in human neuroblastoma cells	17
Selenium protects against cadmium‐induced cardiac injury by attenuating programmed cell death viaPI3K/AKT/PTENsignaling	17

HBCD, TBECH, and BTBPE exhibit cytotoxic effects in human vascular endothelial cells by regulating mitochondria function and ROS production	17
Protective effect of nimbolide against streptozotocin induced gestational diabetes mellitus in rats via alteration of inflammatory reaction, oxidative stress, and gut microbiota	17
MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell‐cycle checkpoint gene CCNB1	17
Pitavastatin and metformin synergistically activate apoptosis and autophagy in pancreatic cancer cells	17
Triclosan regulates the Nrf2/HO‐1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons	17
Arecoline induces heart injure via Fas/Fas ligand apoptotic pathway in heart of Sprague–Dawley rat	17
The therapeutic effects of Prunella vulgaris against fluoride‐induced oxidative damage by using the metabolomics method	17
Syringin alleviates ovalbumin‐induced lung inflammation in BALB/c mice asthma model via NF‐κB signaling pathway	17
Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells	17
Thiamethoxam‐induced oxidative stress, lipid peroxidation, and disturbance of steroidogenic genes in male rats: Palliative role of Saussurea lappa and Silybum marianum	17
LncRNA SNHG14 contributes to proinflammatory cytokine production in rheumatoid arthritis via the regulation of the miR‐17‐5p/MINK1‐JNK pathway	17
Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite‐induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats	17
LncRNA PVT1 contributes to invasion and doxorubicin resistance of bladder cancer cells through promoting MDM2 expression and AURKB‐mediated p53 ubiquitination	16
circ_0089153 exacerbates breast cancer cells proliferation and metastasis via sponging miR‐2467‐3p/E2F6	16
Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di‐N‐butyl‐phthalate	16
Toxicogenicity and mechanistic pathways of aflatoxinB1induced renal injury	16
Long noncoding RNA FAM66C promotes tumor progression and glycolysis in intrahepatic cholangiocarcinoma by regulating hsa‐miR‐23b‐3p/KCND2 axis	16
Low concentration triphenyl phosphate fuels proliferation and migration of hepatocellular carcinoma cells	16
CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR‐431/SLC7A11 axis	16
Traditional Chinese medicine formula T33 inhibits the proliferation of human colorectal cancer cells by inducing autophagy	16
Combined lead and zincoxide‐nanoparticlesinduced thyroid toxicity through8‐OHdGoxidative stress‐mediated inflammation, apoptosis, and Nrf2 activation in rats	15
Effects of 2,4‐dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy‐related proteins as well as the protective effect of Lycium barbarum polysaccharide in	15
The crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress promoted ATF4‐mediated mitophagy induced by hexavalent chromium	15
2,4‐dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body‐induced autophagy disorder in microglia and the protective effect of Lycium barbarum polys	15
Butyrate enhances erastin‐induced ferroptosis of lung cancer cells via modulating the ATF3/SLC7A11 pathway	15
Ochratoxin A induces human kidney tubular epithelial cell apoptosis through regulating lipid raft/PTEN/AKT signaling pathway	15
Hsp70 overexpression in Drosophila hemocytes attenuates benzene‐induced immune and developmental toxicity via regulating ROS/JNK signaling pathway	15
Chitosan attenuated the neurotoxicity‐induced titanium dioxide nanoparticles in brain of adult rats	15
TRIP13 exerts a cancer‐promoting role in cervical cancer by enhancing Wnt/β‐catenin signaling via ACTN4	15
Effects of naringin on oxidative stress, inflammation, some reproductive parameters, and apoptosis in acrylamide‐induced testis toxicity in rat	15
Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics	15
Effects of lead exposure on the activation of microglia in mice fed with high‐fat diets	15
CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR‐375/SLC7A11 axis	15
Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving kinematics of sperm, and blunting the downreg	14
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis	14
Adverse effects of chronic ammonia stress on juvenile oriental river prawn (Macrobrachium nipponense) and alteration of glucose and ammonia metabolism	14
Circ‐SNAP47 (hsa_circ_0016760) and miR‐625‐5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP‐tolerant NSCLC cells via ceRNA pathway	14
LncRNA RHPN1‐AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR‐7‐5p/EGFR/PI3K/AKT/mTOR signaling pat	14
ROS generation is involved in titanium dioxide nanoparticle‐induced AP‐1 activation through p38 MAPK and ERK pathways in JB6 cells	14
LINC01234 aggravates cell growth and migration of triple‐negative breast cancer by activating the Wnt pathway	14
Coordinating single‐cell and bulk RNA‐seq in deciphering the intratumoral immune landscape and prognostic stratification of prostate cancer patients	14
Sinapic acid mitigates methotrexate‐induced hepatic injuries in rats through modulation of Nrf‐2/HO‐1 signaling	14
hUC‐MSCs exosomal miR‐451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF‐PI3K‐AKT signaling pathway	14
ROCK inhibitor attenuates carbon blacks‐induced pulmonary fibrosis in mice via Rho/ROCK/NF‐kappa B pathway	14
The antagonistic effect of melatonin onTBBPA‐induced apoptosis and necroptosis viaPTEN/PI3K/AKTsignaling pathway in swine testis cells	14
Adolescent cadmium exposure impairs cognition and hippocampal neurogenesis in C57BL/6 mice	14
Sub‐chronic exposure to ammonia inhibits the growth of juvenile Wuchang bream (Megalobrama amblycephala) mainly by downregulation of growth hormone/insulin‐like growth factor axis	14
Uranium induces kidney cells apoptosis via reactive oxygen species generation, endoplasmic reticulum stress and inhibition of PI3K/AKT/mTOR signaling in culture	14
Integrated analysis of multi‐omics data on epigenetic changes caused by combined exposure to environmental hazards	14
LINC00473 downregulation facilitates trophoblast cell migration and invasion via the miR‐15a‐5p/LITAF axis in pre‐eclampsia	14
Poria cocos (Fuling) targets TGFβ/Smad7 associated collagen accumulation and enhances Nrf2‐antioxidant mechanism to exert anti‐skin aging effects in human dermal fibroblasts	13
Mechanisms of acrolein induces toxicity in human umbilical vein endothelial cells: Oxidative stress, DNA damage response, and apoptosis	13
PM_2.5 promotes pulmonary fibrosis by mitochondrial dysfunction	13
Prognostic impact of lactylation‐associated gene modifications in clear cell renal cell carcinoma: Insights into molecular landscape and therapeutic opportunities	13
Long non‐coding RNA NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via miR‐577/COBLL1 axis	13
Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model	13
Seven traditional Chinese herbal extracts fermented by Lactobacillus rhamnosus provide anti‐pigmentation effects by regulating the CREB/MITF/tyrosina	13
RNA‐binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3′UTR with miR‐92a‐3p	13
Puerarin alleviates cadmium‐induced oxidative damage to bone by reducing autophagy in rats	13
circZFR regulates thyroid cancer progression by the miR‐16/MAPK1 axis	13
Protective effect of hesperidin against N,N′‐dimethylhydrazine induced oxidative stress, inflammation, and apoptotic response in the colon of Wistar rats	13
LncRNA NCK1‐AS1 exerts oncogenic property in gastric cancer by targeting the miR‐22‐3p/BCL9 axis to activate the Wnt/β‐catenin signaling	13
Surfactin induces ER stress‐mediated apoptosis via IRE1‐ASK1‐JNK signaling in human osteosarcoma	13
CRABP2 accelerates epithelial mesenchymal transition in serous ovarian cancer cells by promoting TRIM16 methylation via upregulating EZH2 expression	13
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability	13
Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats	13
LncRNA MEG3 restrained pulmonary fibrosis induced by NiO NPs via regulating hedgehog signaling pathway‐mediated autophagy	13
Dieckol alleviates dextran sulfate sodium‐induced colitis via inhibition of inflammatory pathway and activation of Nrf2/HO‐1 signaling pathway	13
Glyburide attenuates B(a)p and LPS‐induced inflammation‐related lung tumorigenesis in mice	13
Corynoline protects lipopolysaccharide‐induced mastitis through regulating AKT/GSK3β/Nrf2 signaling pathway	13
Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR‐3529‐5p/RNASEH2A axis under the competitive endogen	13
In vitro antimetastatic activity of Momordica balsamina crude acetone extract in HT‐29 human colon cancer cells	12
MiR‐1246 is responsible for lung cancer cells‐derived exosomes‐mediated promoting effects on lung cancer stemness via targeting TRIM17	12
CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR‐194‐5p/Fzd6 axis and beta‐catenin signaling	12
Inhibition of the notch signaling pathway overcomes resistance of cervical cancer cells to paclitaxel through retardation of the epithelial–mesenchymal transition process	12
Exposure to neonicotinoids and serum testosterone in men, women, and children	12
Inhibition of NCAPG expression inactivates the Wnt/β‐catenin signal to suppresses endometrial cancer cell growth in vitro	12
GPX4 utilization by selenium is required to alleviate cadmium‐induced ferroptosis and pyroptosis in sheep kidney	12
Naringin against doxorubicin‐induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up‐regulation of SIRT1	12
T‐2 toxin‐induced femur lesion is accompanied by autophagy and apoptosis associated with Wnt/β‐catenin signaling in mice	12

Naringin alleviates acetaminophen‐induced acute liver injury by activating Nrf2 via CHAC2 upregulation	12
Nano‐selenium attenuates mitochondrial‐associated apoptosis via the PI3K/AKT pathway in nickel‐induced hepatotoxicity in vivo and in vitro	12
Butein induces cellular senescence through reactive oxygen species‐mediated p53 activation in osteosarcoma U‐2 OS cells	12
Melatonin improves bisphenol A‐induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 MAPK signaling pathway in FLK‐BLV cells	12
Long noncoding RNA ST8SIA6‐AS1 promotes cell proliferation and metastasis in triple‐negative breast cancer by targeting miR‐145‐5p/CDCA3 to inactivate the p53/p21 sign	12
LncRNA PSMA3‐AS1 promotes cell proliferation, migration, and invasion in ovarian cancer by activating the PI3K/Akt pathway via the miR‐378a‐3p/GALNT3 axis	12
CircFAM64A enhances cellular processes in triple‐negative breast cancer by targeting the miR‐149‐5p/CDT1 axis	12
Carvacrol protects against λ‐Cyhalothrin‐induced hepatotoxicity and nephrotoxicity by modulating oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy	12
Cadmium modulates steatosis, fibrosis, and oncogenic signaling in liver cancer cells by activating notch and AKT/mTOR pathways	12
miR‐486‐3p regulates CyclinD1 and promotes fluoride‐induced osteoblast proliferation and activation	12
Long non‐coding RNA DUXAP9 promotes hepatocellular carcinoma cell stemness via directly interacting with sox9	12
Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma	11
Protective effect of C‐phycocyanin and apo‐phycocyanin subunit on programmed necrosis ofGC‐1 spg cells induced byH₂O₂	11
Galectin‐3 facilitates inflammation and apoptosis in chondrocytes through upregulation of the TLR‐4‐mediated oxidative stress pathway in TC28a2 human chondrocyte cells	11
Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA‐183/135b‐FOXO1/TXNIP/NLRP3 inflammasome	11
Tussilagone protects acute lung injury from PM2.5 via alleviating Hif‐1α/NF‐κB‐mediated inflammatory response	11
ABCA8 inhibits breast cancer cell proliferation by regulating the AMP activated protein kinase/mammalian target of rapamycin signaling pathway	11
Apigenin attenuates inflammatory response in allergic rhinitis mice by inhibiting the TLR4/MyD88/NF‐κB signaling pathway	11
Histopathological evaluation of the interrenal gland (adrenal homolog) of Japanese medaka (Oryzias latipes) exposed to graphene oxide	11
Dihydromyricetin inhibits cancer cell migration and matrix metalloproteinases‐2 expression in human nasopharyngeal carcinoma through extracellular signal‐regulated kinase signaling pathway	11
Low concentrations of 17β‐estradiol exacerbate tamoxifen resistance in breast cancer treatment through membrane estrogen receptor‐mediated signaling pathways	11
Acute iron oxide nanoparticles exposure induced murine eosinophilic airway inflammation via TLR2 and TLR4 signaling	11
Fucoxanthin decreases lipopolysaccharide‐induced acute lung injury through the inhibition of RhoA activation and the NF‐κB pathway	11
Bisphenol A (BPA) induces apoptosis of mouse Leydig cells via oxidative stress	11
A macrolide from Streptomyces sp. modulates apoptosis and autophagy through Mcl‐1 downregulation in human breast cancer cells	11
LncRNA LINC00115 facilitates lung cancer progression through miR‐607/ITGB1 pathway	11
Estrogen receptor‐α36 is involved in diallyl sulfide‐induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells	11
Bergenin alleviates H₂O₂‐induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR‐γ/NF‐κB pathway	11
Glyphosate‐based herbicides induces autophagy in IPEC‐J2 cells and the intervention of N‐acetylcysteine	11
Fenofibrate inhibits hypoxia‐inducible factor‐1 alpha and carbonic anhydrase expression through activation of AMP‐activated protein kinase/HO‐1/Sirt1 pathway in glioblastoma cells	11
N‐acetylcysteine reduced the immunotoxicity effects induced in vitro by azoxystrobin and iprodione fungicides in mice	10
Effects of benzo(a)pyrene at environmentally relevant doses on embryo‐fetal development in rats	10
The role of H3K9me2‐regulated base excision repair genes in the repair of DNA damage induced by arsenic in HaCaT cells and the effects of Ginkgo biloba	10
DNA damage and cell apoptosis induced by fungicide difenoconazole in mouse mononuclear macrophage RAW264.7	10
6,8‐Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53	10
Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine	10
In vivo hepatoprotective effect of Morinda elliptica stem extract against liver fibrosis induced by thioacetamide	10
Splicing factor SNRPA associated with microvascular invasion promotes hepatocellular carcinoma metastasis through activating NOTCH1/Snail pathway and is mediated by circSEC6	10
Cadmium cytotoxicity and possible mechanisms in human trophoblast HTR‐8/SVneo cells	10
Effect of resveratrol on the inflammatory status and oxidative stress in thymus gland and spleen of sulfoxaflor‐treated rats	10
Dichloroacetate attenuates the stemness of hepatocellular carcinoma cells via promoting nucleus‐cytoplasm translocation of YAP	10
Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue	10
Microcrystalline silica particles induce inflammatory response via pyroptosis in primary human respiratory epithelial cells	10
Shikonin ameliorates injury and inflammatory response of LPS‐stimulated WI‐38 cells via modulating the miR‐489‐3p/MAP2K1 axis	10
Integrated fecal microbiome and metabolome analysis explore the link between polystyrene nanoplastics exposure and male reproductive toxicity in mice	10
SIRT1/mTOR pathway‐mediated autophagy dysregulation promotes Pb‐induced hepatic lipid accumulation in HepG2 cells	10
Subacute toxicity of chlorpyrifos on histopathological damages, antioxidant activity, and pro‐inflammatory cytokines in the rat model	10
Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation	10
β‐Amyrin ameliorates diabetic nephropathy in mice and regulates the miR‐181b‐5p/HMGB2 axis in high glucose‐stimulated HK‐2 cells	10
circ_0008797 attenuates non‐small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR‐301a‐3p/SOCS2	10
Compound essential oils relieve oxidative stress caused by PM₂_.5 exposure by inhibiting autophagy through the AMPK/mTOR pathway	10
MicroRNA‐455‐3p functions as a tumor suppressor by targeting HDAC2 to regulate cell cycle in hepatocellular carcinoma	10
NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway	10
Limonene protects human skin keratinocytes against UVB‐induced photodamage and photoaging by activating the Nrf2‐dependent antioxidant defense system	10
Ginsenoside Rg1 suppresses paraquat‐induced epithelial cell senescence by enhancing autophagy in an ATG12‐dependent manner	10
Linseed ameliorates renal apoptosis in rat fetuses induced by single or combined exposure to diesel nanoparticles or fenitrothion by inhibiting transcriptional activation of p21/p53 and caspase‐3/9 th	10
Involvement of miRNAs in response to oxidative stress induced by the steroidal glycoalkaloid α‐solanine in hepatocellular carcinoma cells	10
Nickel induces hepatotoxicity by mitochondrial biogenesis, mitochondrial dynamics, and mitophagy dysfunction	10
Limonin ameliorates acute pancreatitis by suppressing JAK2/STAT3 signaling pathway	10
Borax regulates iron chaperone‐ and autophagy‐mediated ferroptosis pathway in glioblastoma cells	10
Fat1 suppresses the tumor‐initiating ability of nonsmall cell lung cancer cells by promoting Yes‐associated protein 1 nuclear‐cytoplasmic translocation	10
Impact of Saussurea lappa root extract against copper oxide nanoparticles induced oxidative stress and toxicity in rat cardiac tissues	10
miR‐222‐5p promotes dysfunction of human vascular smooth muscle cells by targeting RB1	10
Caffeic acid phenethyl ester induces radiosensitization via inhibition of DNA damage repair in androgen‐independent prostate cancer cells	10
Effect of prenatal exposure to Benzo[a]pyrene on ovarian toxicity and reproductive dysfunction: Protective effect of atorvastatin in the embryonic period	10
Investigations into ferroptosis in methylmercury‐induced acute kidney injury in mice	10
Panax ginseng modulates oxidative stress, DNA damage, apoptosis, and inflammations induced by silicon dioxide nanoparticles in rats	10
Long noncoding RNA OIP5‐AS1 promotes the stemness of lung cancer cells through enhancing Oct4 mRNA stability	10
Neuroprotective effect of targeted regulatory Nrf2 gene on rats with acute brain injury induced by carbon monoxide poisoning	9
Phosphorylation of p53 by Cdk5 contributes to benzo[a]pyrene‐induced neuronal apoptosis	9
A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR‐1 mediated mitochondrial dysfunction and apoptosis	9
Shenlian extract protects against ultrafine particulate matter‐aggravated myocardial ischemic injury by inhibiting inflammation response via the activation of NLRP3 inflammasomes	9
Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells	9
Molecular cloning and oxidative‐stress responses of a novel Phi class glutathione S‐transferase (GSTF) gene in the freshwater algae Closterium ehrenbergii	9
DNA damage induced by cylindrospermopsin on different tissues of the biomonitor fish Poecilia reticulata	9
Parental PM₂_.5 exposure changes Th17/Treg cells in offspring, is associated with the elevation of blood pressure	9
Trimetazidine improved adriamycin‐induced cardiomyopathy by downregulating TNF‐α, BAX, and VEGF immunoexpression via an antioxidant mechanism	9
Di(2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress	9
CCL3‐CCR5 axis promotes cell migration and invasion of colon adenocarcinoma via Akt signaling pathway	9
Mechanisms underlying protective effects of vitamin E against mycotoxin deoxynivalenol‐induced oxidative stress and its related cytotoxicity in primary human brain endothelial cells	9
Procyanidin protects human retinal pigment epithelial cells from high glucose by inhibiting autophagy	9
Dibutyl phthalate causesMC3T3‐E1cell damage by increasingROSto promote thePINK1/Parkin‐mediated mitophagy	9
miRNA‐34c‐5p targets Fra‐1 to inhibit pulmonary fibrosis induced by silica through p53 and PTEN/PI3K/Akt signaling pathway	9
Effects of a phthalate metabolite mixture on both normal and tumoral human prostate cells	9
miR‐219a‐5p inhibits the pyroptosis in knee osteoarthritis by inactivating the NLRP3 signaling via targeting FBXO3	9
Long non‐coding RNA LINC00514 promotes the proliferation and invasion through the miR‐708‐5p/HOXB3 axis in cervical squamous cell carcinoma	9
Downregulation of estrogen receptor‐α36 expression attenuates metastasis of hepatocellular carcinoma cells	9
The single‐cell evolution trajectory presented different hypoxia heterogeneity to reveal the carcinogenesis of genes in clear cell renal cell carcinoma: Based on multiple omics and real experimental v	9
FAM83A has a pro‐tumor function in ovarian cancer by affecting the Akt/Wnt/β‐catenin pathway	9
Erianin suppressed lung cancer stemness and chemotherapeutic sensitivity via triggering ferroptosis	9
Green synthesized nickel doped cobalt ferrite nanoparticles exhibit antibacterial activity and induce reactive oxygen species mediated apoptosis in MCF‐7 breast cancer cells through inhibition of PI3K	9
Activation of Nrf2/HO‐1 signaling pathway attenuates ROS‐mediated autophagy induced by silica nanoparticles in H9c2 cells	9
Bisdemethoxycurcumin suppresses human brain glioblastoma multiforme GBM 8401 cell migration and invasion via affecting NF‐κB and MMP‐2 and MMP‐9 signaling p	9
Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation	9
Eucalyptol antagonized the apoptosis and immune dysfunction of grass carp hepatocytes induced by tetrabromobisphenol A by regulating ROS/ASK1/JNK pathway	9