Hepatobiliary & Pancreatic Diseases International

Article	Citations
Palmar metastasis of hepatocellular carcinoma: An uncommon case report	42
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas mimicking pancreatic pseudocyst	38
Relevant content	37
Cryptococcosis in patients with liver cirrhosis: Death risk factors and predictive value of prognostic models	36
Primary pancreatic lymphoma diagnosed by endoscopic ultrasound-guided fine needle biopsy	35
Application of extended criteria donor liver grafts in liver transplantation	33
Inadvertent perioperative hypothermia and surgical site infections after liver resection	33
Meetings and Courses	32
CK2α causes stemness and chemotherapy resistance in liver cancer through the Hedgehog signaling pathway	28
Laparoscopic extended right hepatectomy for posterior and completely caudate massive liver tumor (with videos)	28
Impact of metabolic disorders on gallstone disease and perioperative recovery after laparoscopic cholecystectomy	26
Advances and current research status of early diagnosis for gallbladder cancer	26
Pre-MASLD: Should it be defined separately?	25
Post-hepatectomy liver failure: A timeline centered review	22
Key factors and potential drug combinations of nonalcoholic steatohepatitis: Bioinformatic analysis and experimental validation-based study	21
Liver transplantation as an alternative for the treatment of neuroendocrine liver metastasis: Appraisal of the current evidence	21
Minimizing the risk of small-for-size syndrome after liver surgery	20
Fecal cytolysin does not predict disease severity in acutely decompensated cirrhosis and acute-on-chronic liver failure	19
The pathologic relevance of metabolic criteria in patients with biopsy-proven nonalcoholic fatty liver disease and metabolic dysfunction associated fatty liver disease: A multicenter cross-sectional s	19
Current controversies and challenges for resection of pancreatic ductal adenocarcinoma in pancreatic head aiming at cure	17
Oncogenic Wnt3a is a promising sensitive biomarker for monitoring hepatocarcinogenesis	17
Nrf2 and Her3 co-expression in cholangiocarcinoma: Possible biological pathways for potential therapeutic approach	17
Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver, diaphragm and lung without peritoneal dissemination or distant metastasis	16
Recurrence and survival following microwave, radiofrequency ablation, and hepatic resection of colorectal liver metastases: A systematic review and network meta-analysis	15
Reply to: Endovascular treatment for early hepatic artery occlusion after liver transplantation: Angioplasty or stent	15

Characteristics and risk differences of different tumor sizes on distant metastases of pancreatic neuroendocrine tumors: A retrospective study in the SEER database	15
The effects of stereotactic body radiotherapy on peripheral natural killer and CD3+CD56+ NKT-like cells in patients with hepatocellular carcinoma	14
CT‐based radiomics to predict development of macrovascular invasion in hepatocellular carcinoma: A multicenter study	14
Long-term outcomes of endoscopic papillary large-balloon dilation (12–15 mm) with or without limited sphincterotomy for removal of bile duct stones	14
Research progress and prospects of circulating tumor cells in hepatocellular carcinoma	14
Low-pressure pulse flushing choledochoscopy combined with neodymium laser lithotripsy for the treatment of intrahepatic bile duct stones	14
Challenges for pediatric liver transplantation in the mainland of China: Where we are and where to go. Reflections from worldwide largest pediatric liver transplantation program	13
Fibrotic liver extracellular matrix induces cancerous phenotype in biomimetic micro-tissues of hepatocellular carcinoma model	13
Liver transplantation for hepatocellular carcinoma: Current status in Hong Kong, China	13
Call for action: Increased healthcare utilization with growing use of percutaneous cholecystectomy tube over initial cholecystectomy in cirrhotics	13
A deep learning model based on contrast-enhanced computed tomography for differential diagnosis of gallbladder carcinoma	13
Technical aspects in pancreaticoduodenectomy and therapeutic strategies for pancreatic cancer: History, current status, and future perspectives	13
Thanks	12
T-tube bridging fistula jejunal anastomosis for treatment of pancreatic lumbar dorsal fistula after necrotizing pancreatitis	12
Gastroduodenal artery disconnection during liver transplantation decreases non-anastomotic stricture incidence	12
Branching patterns of the left portal vein and consequent implications in liver surgery: The left anterior sector	12
Sirolimus improves the prognosis of liver recipients with hepatocellular carcinoma: A single-center experience	12
Pancreatic acinar cell carcinoma with liver metastases	12
Pancreatic cancer with gastrointestinal obstruction as an initial symptom	12
Circulating tumor cell dynamic detecting to optimize neoadjuvant chemotherapy combined with liver transplantation in perihilar cholangiocarcinoma	11
Gallbladder perforation: A single-center experience in north India and a step-up approach for management	11
Risk factors and outcomes for patients with pancreatic cancer undergoing surgical exploration without resection due to metastatic disease: A national cohort study	11
Robotic versus laparoscopic surgery for sporadic benign insulinoma: Short- and long-term outcomes	11
Serum exosome-derived ALDH1A1 can greatly predict the prognosis of patients with hepatitis E virus-related acute liver failure	10
Tri-modal death distribution towards personalized management of intraductal papillary neoplasm of the bile duct patients: Every story has its own conclusion	10
Timing of hepatectomy following the Omicron variant infection for vaccinated-patients: A retrospective cohort study	10
Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review	10
Variations of the hilar biliary confluence from postoperative cholangiography in Chinese population	10
Interventional treatment options for management of delayed arterial hemorrhage after major hepato-pancreatic-biliary surgery	10
Contribution of gut microbiota to drug-induced liver injury	10
Hypermethylation of thymosin β4 predicts a poor prognosis for patients with acute-on-chronic hepatitis B liver failure	9
Liver transplantation and liver resection as alternative treatments for primary hepatobiliary and secondary liver tumors: Competitors or allies?	9
Terlipressin versus placebo in living donor liver transplantation	9
A new heparin fragment decreases liver ischemia-reperfusion injury	8
A new surgical approach for pseudocyst of dorsal pancreas	8
Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma: A single-arm, multicenter, prospective study	8
Six-hour local 4 °C dual hypothermic oxygenated machine perfusion improves the preservation of porcine liver after cardiac death using an ex vivo reperfusion model	8
Nomogram for prediction of hepatocellular carcinoma recurrence after liver resection	8
Predictors of recurrent bile duct stone after clearance by endoscopic retrograde cholangiopancreatography: A case-control study	8
Preoperative lymphocyte to C-reactive protein ratio as a new prognostic indicator in patients with resectable gallbladder cancer	8
Etiology and classification of acute pancreatitis in children admitted to ICU using the Pediatric Sequential Organ Failure Assessment (pSOFA) score	8
Alpha-fetoprotein, protein induced by vitamin K absence or antagonist-II, lens culinaris agglutinin-reactive fraction of alpha-fetoprotein alone and in combination for early detection of hepatocellula	8
Vancomycin-induced acute kidney injury after liver transplantation	8
Does drainage tube affect recovery after laparoscopic cholecystectomy?	7
Acute hepatitis associated with increased atypical lymphocyte	7
Split liver transplantation with complicated portal vein variations in graft	7
Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension	7
Clinical analysis of Wernicke encephalopathy after liver transplantation	7
Meetings and Courses	7
Integrated chromosomal instability and tumor microbiome redefined prognosis-related subtypes of pancreatic cancer	7

Diagnostic value and immune infiltration characterization of WTAP as a critical m6A regulator in liver transplantation	7
Hepatic cystic lesions mimicking liver abscess on imaging: A report of two cases	7
Repeat hepatectomy for recurrent colorectal liver metastases: A comparative analysis of short- and long-term results	7
No-touch recipient hepatectomy in liver transplantation for liver malignancies: A state-of-the-art review	7
The effect of adjuvant transarterial chemoembolization for hepatocellular carcinoma after liver resection based on risk stratification	7
Cisplatin induces acute liver injury by triggering caspase-3/GSDME-mediated cell pyroptosis	7
Unilateral versus bilateral Y-type stent-in-stent metal stent insertions in inoperable malignant hilar biliary strictures: A multicenter retrospective study	7
Meetings and Courses	6
Current and emerging immunotherapeutic approaches for biliary tract cancers	6
Hepatopancreatoduodenectomy for the treatment of extrahepatic cholangiocarcinoma	6
Thanks	6
Portal vein embolization combined with ex vivo liver resection and autotransplantation: A novel treatment strategy for end-stage and metastatic hepatic alveolar echinococcosis	6
HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-κB pathway	6
Laparoscopic pancreaticoduodenectomy with portal or superior mesenteric vein resection and reconstruction for pancreatic cancer: A single-center experience	6
Application of ultrasonography-elastography score to suspect porto-sinusoidal vascular disease in patients with portal vein thrombosis	6
Isolated anti-HBc is an independent risk factor for tumor recurrence in intrahepatic cholangiocarcinoma after curative resection	6
Reply to “Wnt/beta-catenin signaling inhibitors and nonalcoholic fatty liver disease: Potential therapeutic implications”	6
Middle hepatic vein variation provides a safe path for anterior transection of hepatocellular carcinoma in caudate lobe	6
Research progress of lncRNA and miRNA in hepatic ischemia-reperfusion injury	6
Local recurrence rate as quality indicator in surgery for pancreatic cancer?	6
Predictive value of postoperative serum lipase level for postoperative pancreatic fistula after pancreaticoduodenectomy	6
Validation and performance of three scoring systems for predicting primary non-function and early allograft failure after liver transplantation	6
The role of liver sinusoidal endothelial cells in liver remodeling after injury	6
Meetings and Courses	6
Gut microbiome and nonalcoholic fatty liver disease	6
Chinese expert consensus on quantitatively monitoring and assessing immune cell function status and its clinical application (2024 edition)	6
Impact of cirrhosis-related complications on posttransplant survival in patients with acute-on-chronic liver failure	6
Left hepatic marginal hemangioma with features resembling gastric stromal tumor	6
Sinistral portal hypertension and distal splenorenal shunt during pancreatic surgery	6
Mitochondrial dysfunction in the pathogenesis of acute pancreatitis	6
Endoscopic retrograde cholangiopancreatography management for choledochocele in a young female	6
Expert consensus on the application of the magnetic anchoring and traction technique in thoracoscopic and laparoscopic surgery	5
Left abdominal mass with carcinosis: Unusual presentation of pancreatic acinar cell carcinoma	5
Are outcomes for emergency index-admission laparoscopic cholecystectomy performed by hepatopancreatobiliary surgeons better compared to non-hepatopancreatobiliary surgeons? A 10-year audit using 1:1 p	5
Propensity score matching analysis for clinical impact of braided-type versus laser-cut-type covered self-expandable metal stents for endoscopic ultrasound-guided hepaticogastrostomy	5
ANNOUNCEMENT	5
Total three-dimensional laparoscopic radical resection for Bismuth type IV hilar cholangiocarcinoma	5
Identification of pyroptosis-related lncRNAs for constructing a prognostic model and their correlation with immune infiltration in pancreatic cancer	5
Endoscopic hemostasis using self-expandable metal stent combined with PuraStatⓇ for patient with high risk of post-endoscopic sphincterotomy bleeding (with video)	5
Meetings and Courses	5
YAP activates pancreatic stellate cells and enhances pancreatic fibrosis	5
Chinese clinical practice guidelines for ultrasound-guided irreversible electroporation of liver cancer (version 2022)	5
China Liver Transplant Registry plays an important role in liver transplantation	5
Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624–3p/WEE1 axis	5
Announcement	5
A rare type of choledochal cysts of Todani type IV-B with typical pancreaticobiliary maljunction	4
Simplified calculation of bile cholesterol saturation index	4
Safety and effectiveness of balloon catheter-assisted ultrasound-guided percutaneous microwave ablation in difficult-site liver cancer	4
Combined hepatic segment color rendering technique improves the outcome of anatomical hepatectomy in patients with hepatocellular carcinoma	4
Wnt/beta-catenin signaling inhibitors and nonalcoholic fatty liver disease: Potential therapeutic implications	4
A complicated peribiliary cyst: An unusual hilar cholangiocarcinoma mimic	4
Contrast-enhanced ultrasound predicts microvascular invasion in patients with hepatocellular carcinoma	4
Aberrant bile duct communicating with the cystic duct: From early detection to management of late surgical complications	4
Meetings and Courses	4
Radiofrequency ablation is an inferior option to liver resection for solitary hepatocellular carcinoma ≤ 5 cm without cirrhosis: A population-based study with stratification by tumor size	4
Successful liver transplantation from a donor with immune thrombocytopenia	4
Development and validation of a novel model to predict liver-related mortality in patients with idiosyncratic drug-induced liver injury	4
Clinical application of COVID-19 vaccine in liver transplant recipients	4
Risk factors of recurrent choledocholithiasis following therapeutic endoscopic retrograde cholangiopancreatography	4
Glucagonoma syndrome with necrolytic migratory erythema as initial manifestation	4
Timely synergic surgical and radiological aggressiveness improves perioperative mortality after hemorrhagic complication in Whipple procedure	4
Meetings and Courses	4
Robot assisted anatomical liver resection is safe for patient with hepatocellular carcinoma underlying Fontan-associated liver disease	4
Mirizzi syndrome: Problems and strategies	4
Enhanced fluorescence cholangiography with indocyanine green: A methodology for reducing the potential hazard of bile duct injury during laparoscopic cholecystectomy	4
A successful case report of menstrual blood derived-mesenchymal stem cell-based therapy for Wilson's disease	4
A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma: Construction and analysis of a circRNA-mediated competing endogenous RNA network	4
Regression of recurrent granulosa cell tumor liver metastases following selective internal radiation therapy	4
Full laparoscopic anatomical liver segment VII resection with preferred Glissonean pedicle and dorsal hepatic approach	4
An NSQIP survey of outcomes after resection of choledochal cysts in adults	4
Bilateral lung transplantation, a new option for pulmonary metastasis from hepatocellular carcinoma?	4
Benign stricture of bilioenteric anastomosis after Whipple with synthetic polypropylene suture	3
Immunotherapy for hepatobiliary malignancies: Progress and prospective	3
Microbiota-related metabolites correlated with the severity of COVID-19 patients	3
High perioperative lactate levels and decreased lactate clearance are associated with increased incidence of posthepatectomy liver failure	3
Liver transplantation using an otherwise-wasted partial liver resection graft	3
ADAMTS12 promotes migration and epithelial-mesenchymal transition and predicts poor prognosis for pancreatic cancer	3
Pure laparoscopic full-size liver transplantation in adult	3
Acetylsalicylic acid for metal stent in malignant distal common bile duct obstruction: A randomized controlled trial	3
Right hepatectomy with a cholangiojejunostomy and hepaticojejunostomy for unilobar Caroli's syndrome	3

Laparoscopic enucleation for pancreatic lipomatous hamartoma	3
Long-term survival after pancreaticoduodenectomy in patients with ductal adenocarcinoma of the pancreatic head	3
Liver graft procurement in neurologically deceased donor: Hospital Italiano of Buenos Aires approach	3
Establishment and effectiveness verification of a new pattern for hepatitis C elimination in hospital	3
Combination therapy of dabrafenib plus trametinib in patients with BRAF-mutated biliary tract cancer	3
Inferior vena cava reconstruction in extended right hepatectomy	3
Robotic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: Analysis of surgical outcomes and long-term prognosis in a high-volume center	3
Upper gastrointestinal bleeding due to left side portal hypertension after pancreatic surgery	3
Involvement of the circular RNA/microRNA/glucose-6-phosphate dehydrogenase axis in the pathological mechanism of hepatocellular carcinoma	3
Prevotella copri-produced 5-aminopentanoic acid promotes pediatric metabolic dysfunction-associated steatotic liver disease	3
A robust genomic-based prognostic model for the assessment of cancer stemness and survival for patients with hepatocellular carcinoma	3
In vitro-derived insulin-producing cells modulate Th1 immune responses and induce IL-10 in streptozotocin-induced mouse model of pancreatic insulitis	3
Enhanced recovery after surgery in perioperative period of liver transplantation	3
Prevalence and prognosis of acute pancreatitis in critically ill patients with COVID-19	3
Effects of triggers of senescence and senolysis in murine pancreatic cancer cells	3
Percutaneous ultrasound and endoscopic ultrasound-guided biopsy of solid pancreatic lesions: An analysis of 1074 lesions	3
Three-dimensional modeling in complex liver surgery and liver transplantation	3
Insights in living-donor liver transplantation associated with two-stage total hepatectomy: First case in neuroendocrine tumor metastases and functional assessment techniques	3
Chronic viral hepatitis B complicated by hepatitis E virus infection	3
The terminology of the 2012 Atlanta consensus conference on post-inflammatory collections after acute pancreatitis: An assessment of utilization in practice	3
Microbiological cultures and antimicrobial prophylaxis in patients undergoing total pancreatectomy with islet cell autotransplantation	3
Comprehensive review of hepatocellular carcinoma with portal vein tumor thrombus: State of art and future perspectives	3
Successful treatment of complete traumatic transection of the suprahepatic inferior vena cava with veno-venous and cardiopulmonary bypass with hypothermic circulatory arrest	3
Prediction of Clostridium difficile infection based on gut microbial traits in patients with Clostridium difficile colonization	3
The outcomes and safety of patients undergoing endoscopic retrograde cholangiopancreatography combining a single-use cholangioscope and a single-use duodenoscope: A multicenter retrospective internati	3
Fat necrosis of liver in a patient with mixed type liver cirrhosis	3
“Parenchyma transection-first” strategy is superior to “tunnel-first” strategy in robotic spleen-preserving distal pancreatectomy with conservation of splenic vessels	3
Uncoupling protein 2 deficiency of non-cancerous tissues inhibits the progression of pancreatic cancer in mice	3
Mesenteric adipose tissue B lymphocytes promote intestinal injury in severe acute pancreatitis by mediating enteric pyroptosis	3
Added value of indocyanine green fluorescence imaging in liver surgery	2
Chemokines and PI3K/AKT signaling pathway mediate the spontaneously ruptured hepatocellular carcinoma through the regulation of the cell cycle	2
Effect of duodenal papilla morphology on biliary cannulation and complications in patients with common bile duct stones	2
Robotic versus laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: A propensity score-matched analysis	2
Meetings and Courses	2
Hepatic vein reconstruction during hepatectomy: A feasible and underused technique	2
Intraoperative cholangio-ultrasonography (IOCUS) during hepatectomy with resection of the biliary confluence: An effective alternative to intraoperative cholangiography	2
Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma	2
A patient with decompensated cirrhosis and massive chylothorax was cured by liver transplantation	2
Stereotactic body radiotherapy in pancreatic adenocarcinoma	2
A new prognostic model for drug-induced liver injury especially suitable for Chinese population	2
SNHG16 promotes hepatocellular carcinoma development via activating ECM receptor interaction pathway	2
Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series	2
The AGH score is a predictor of disease-free survival and targeted therapy efficacy after liver transplantation in patients with hepatocellular carcinoma	2
Differentiation and immunosuppressive function of CD19+CD24hiCD27+ regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway	2
ATP-citrate lyase regulates stemness and metastasis in hepatocellular carcinoma via the Wnt/β-catenin signaling pathway	2
Radiomics in pancreatic cancer for oncologist: Present and future	2
Ghrelin inhibits IKKβ/NF-κB activation and reduces pro-inflammatory cytokine production in pancreatic acinar AR42J cells treated with cerulein	2
Melatonin attenuates hepatic ischemia-reperfusion injury in rats by inhibiting NF-κB signaling pathway	2
Transarterial chemoembolization as adjuvant treatment after surgery: The cure of huge hepatocellular carcinoma?	2
The efficacy and safety of endoscopic ultrasound-guided fine-needle biopsy in gallbladder masses	2
Meetings and Courses	2
Relevant content	2
Role of gut microbiota in primary biliary cholangitis	2
Value and prognostic factors of repeat hepatectomy for recurrent colorectal liver metastasis	2
Animal models of hepatitis E infection: Advances and challenges	2
Systemic chemotherapy improves outcome of hepatocellular carcinoma patients treated with transarterial chemoembolization	2
Older liver grafts from donation after circulatory death are associated with impaired survival and higher incidence of biliary non-anastomotic stricture	2
Liver transplantation as an alternative for the treatment of intrahepatic cholangiocarcinoma: Past, present, and future directions	2
Overexpression of transcription factor 3 drives hepatocarcinoma development by enhancing cell proliferation via activating Wnt signaling pathway	2
Surgical outcomes and quality of life following exercise-based prehabilitation for hepato-pancreatico-biliary surgery: A systematic review and meta-analysis	2
Radiomics in the diagnosis and treatment of hepatocellular carcinoma	2
Prognostic implication of early posttransplant hypercholesterolemia in liver transplantation for patients with hepatocellular carcinoma	2
Prevalence and characteristics of MAFLD in Chinese adults aged 40 years or older: A community-based study	2
Pancreas sparing duodenectomy in the treatment of primary duodenal neoplasms and other situations with duodenal involvement	2
Practical guide to improving diagnostic sensitivity of bile duct brushings	2
Liver involvement in the course of thymoma-associated multiorgan autoimmunity: The first histological description	2
Recurrent pyogenic cholangitis: An indication for liver transplantation	2
How open is the therapeutic horizon for pancreatic cancer patients?	1
Development and validation of a nomogram model for predicting the risk of gallstone recurrence after gallbladder-preserving surgery	1
Comparison and development of advanced machine learning tools to predict nonalcoholic fatty liver disease: An extended study	1
The “No-touch” technique improves the survival of patients with advanced hepatocellular carcinomas treated by liver transplantation: A single-center prospective randomized controlled trial	1
Pancreatic giant malignancy simulating a gastrointestinal stromal tumor	1
Simultaneous portal and hepatic vein embolization is better than portal embolization or ALPPS for hypertrophy of future liver remnant before major hepatectomy: A systematic review and network meta-ana	1
Meetings and Courses	1
Endoscopic ultrasound-guided liver biopsy in liver transplant recipients: A preliminary experience	1
Nutritional management of severe acute pancreatitis	1
From conventional two-stage hepatectomy to ALPPS: Fifteen years of experience in a hepatobiliary surgery unit	1
Primary biliary cholangitis in pregnancy: A systematic review with meta-analysis	1
Meetings and Courses	1
Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway	1
Prognostic potential of the small GTPase Ran and its methylation in hepatocellular carcinoma	1
Impact of robotic donor partial hepatectomy on male sexual function: A prospective cohort study	1
Overexpression of anillin is related to poor prognosis in patients with hepatocellular carcinoma	1
A rare case of IgG4-related pancreatitis diagnosed preoperatively by endoscopic ultrasound-guided fine needle aspiration	1
Ultrasound-guided percutaneous transhepatic one-step biliary fistulation for biliary stricture after living donor liver transplantation	1
Prolongated and large dose of r-ATG relieves PD-L1 inhibitor-induced allograft rejection in liver transplant recipient	1
Mechanisms and strategies to overcome immunotherapy resistance in hepatobiliary malignancies	1
Conversion surgery for pancreatic cancer: A future paradigm also for stage IV tumors?	1
Visceral adipose tissue predicts severity and prognosis of acute pancreatitis in obese patients	1
Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease	1
Diagnosis and therapy of tacrolimus toxicity in a liver transplant recipient during COVID-19 treatment	1
Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma	1
Meetings and Courses	1
Verteporfin synergizes the efficacy of anti-PD-1 in cholangiocarcinoma	1
Nanosecond pulsed electric field interrupts the glycogen metabolism in hepatocellular carcinoma by modifying the osteopontin pathway	1