OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Translational Medicine is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
A critical evaluation of berberine in NAFLD management: recommendations for improved research methodology	327
Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers	265
Analysis of thyroid carcinoma composition and spatial architecture in the progression of dedifferentiation, lymphatic metastasis, and gastric metastasis	223
KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients	177
Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation	174
A call to reignite the revolutionary spirit of scientific discovery	172
Current perspectives in obesity management: unraveling the impact of different therapy approach in real life obesity care	164
Myomedin variants developed for in vitro PD-L1 diagnostics in tissue samples of non-small cell lung carcinoma patients	163
Associations of types of grains and lifestyle with all-cause mortality among Chinese adults aged 65 years or older: a prospective cohort study	160
Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway	160
CircNDC80 promotes glioblastoma multiforme tumorigenesis via the miR-139-5p/ECE1 pathway	159
Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology	141
Limosilactobacillus reuteri prevents progression of ankylosing spondylitis in mice by restoring gut microbiota-metabolism homeostasis	140
Fully volumetric body composition analysis for prognostic overall survival stratification in melanoma patients	139
Precision information extraction for rare disease epidemiology at scale	139
MicroRNA-24-3p targeting Top1 in perirenal fat is involved in circulating inflammation and high cardiovascular disease risk in patients with primary aldosteronism	132
Correction: NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway	131
From sensitivity to public health: integrating cfMeDIP-seq into early breast cancer detection strategies	130
Gut microbiota analysis and LC-MS-based metabolomics to investigate AMPK/NF-κB regulated by Clostridium butyricum in the treatment of acute pancreatitis	128
Targeting lactylation in a novel metabolic-epigenetic-inflammatory axis mitigates inflammation and promotes healing following corneal injury	128
Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics	126
Advances in gene therapy for mitochondrial genetic disorders: current status and clinical implementation challenges	125
Comprehensive analysis of microglia gene and subpathway signatures for glioma prognosis and drug screening: linking microglia to glioma	124
Deciphering USP8’s pivotal role in cancer: mechanisms, clinical insights and contrasts with its function in pituitary adenomas	123
A 3-tier information fusioned framework featuring explainable deep active optimized CRNet for accurate heart disease prediction	123

Correction to: Augmentation of tumor expression of HLADR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses	119
Correction: Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation	117
Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1	115
Identification of comutation in signaling pathways to predict the clinical outcomes of immunotherapy	114
NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN	114
Silencing PinX1 enhances radiosensitivity and antitumor-immunity of radiotherapy in non-small cell lung cancer	113
Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance	113
Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke	111
A bispecific antibody AP203 targeting PD-L1 and CD137 exerts potent antitumor activity without toxicity	110
Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification	107
Red blood cell-derived arginase release in hemolytic uremic syndrome	106
Advancing polytrauma care: developing and validating machine learning models for early mortality prediction	103
Gender differences in eating habits and sports preferences across age groups: a cross-sectional study	103
The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases	102
Dual immunosuppression mechanism induced by PTP1B in colorectal cancer: upregulation of PD-L1 by FOXO1/miR-34C/c-MYC axis and inhibition of the infiltration of CD8(+) T cell by downregulating of CXCL1	102
Polygenic risk score of metabolic dysfunction-associated steatotic liver disease amplifies the health impact on severe liver disease and metabolism-related outcomes	102
Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis	102
Unleashing endogenous regeneration by senolytics	101
Validity between dual-energy x-ray absorptiometry and bioelectrical impedance for segmental fat analysis and a novel low-cost model developed using anthropometry in young adults	100
Immune-related lncRNAs signature and radiomics signature predict the prognosis and immune microenvironment of glioblastoma multiforme	99
Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance	98
Microplastics as an emerging driver of osteoarthritis: a translational synthesis of environmental exposure, patho-mechanisms, and public health implications	97
Dissecting transcription of the 8q24-MYC locus in prostate cancer recognizes the equilibration between androgen receptor direct and indirect dual-functions	95
Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2 pathway	95
Biological tissue engineering for Fontan failure using decellularized extracellular matrix: a systematic review	95
m6A RNA modification and its emerging roles in diseases: recent advances and therapeutic implications	94
The interplay between driver mutation and oxidative stress in colorectal cancer: from pathogenesis to therapeutics	94
Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease	94
Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer	92
Computational pathology approach for assessment of prognosis and immunotherapy response in pan-gastrointestinal cancer	92
Immunogenicity of adalimumab in patients with noninfectious uveitis based on therapeutic drug monitoring	92
Targeting macrophages: a novel treatment strategy in solid tumors	91
Molecular imaging in gastric cancer: state-of-the-art techniques and emerging opportunities	90
Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer	90
Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma	90
A novel model for predicting prolonged stay of patients with type-2 diabetes mellitus: a 13-year (2010–2022) multicenter retrospective case–control study	89
Prognosis-Related Nutritional Score for Cancer Patients (PRNS): a clinical nutritional score derived from a retrospective cohort study	88
Alterations in whole muscle quality and physiological cross-sectional area measured with quantitative MRI following ACL injury	88
Engineered macrophage membrane-coated dihydroartemisinin nanoparticles with enhanced CCR2 expression improved symptoms in MRL/LPR mice by metabolic reprogramming of proinflammatory macrophages	88
A novel deep learning-based algorithm combining histopathological features with tissue areas to predict colorectal cancer survival from whole-slide images	87
Identification of memory B-cell-associated miRNA signature to establish a prognostic model in gastric adenocarcinoma	86
Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations	85
The Swedish childhood tumor biobank: systematic collection and molecular characterization of all pediatric CNS and other solid tumors in Sweden	85
Magnetique: an interactive web application to explore transcriptome signatures of heart failure	83
Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian popul	82
B cell pathways implicate shared genetic architecture between schizophrenia and immune-mediated diseases	81
Clinical impact of volume of disease and time of metastatic disease presentation on patients receiving enzalutamide or abiraterone acetate plus prednisone as first-line therapy for metastatic castrati	81
Peripheral nerve repair: innovations and future directions	80
Accumulated β-catenin is associated with human atrial fibrosis and atrial fibrillation	80
Dietary patterns, polygenic risk, and kidney cancer incidence: a UK Biobank cohort study	80

Unlocking the potential of EphA2 with precision-guided cancer therapy: bicycle drug conjugates	79
Radiogenomic MRI biomarkers for noninvasive prediction of GPC3 expression and tumor microenvironment in hepatocellular carcinoma	78
Single-cell RNA sequencing reveals a B cell-related immunosuppressive landscape and a potential suppressor in hepatocellular carcinoma	77