OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Translational Medicine is 79. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
A critical evaluation of berberine in NAFLD management: recommendations for improved research methodology	318
Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers	270
Two-sample Mendelian Randomization to evaluate the causal relationship between inflammatory arthritis and female-specific cancers	266
Analysis of thyroid carcinoma composition and spatial architecture in the progression of dedifferentiation, lymphatic metastasis, and gastric metastasis	256
Protectin conjugates in tissue regeneration 1 alleviates sepsis-induced acute lung injury by inhibiting ferroptosis	214
Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma	195
Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2 pathway	168
Dissecting transcription of the 8q24-MYC locus in prostate cancer recognizes the equilibration between androgen receptor direct and indirect dual-functions	166
Peroxynitrite regulates ER stress-mediated Ca2+ flux to mitochondria characterizing cardiac microvascular ischemia–reperfusion injury associated with hyperhomocysteinemia	163
An enhanced-permeability amphiphilic nanogel loaded with sulforaphane for synergistic anti-oxidative and anti-ferroptotic therapy of corneal alkali burn	162
A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment	160
Correction: NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway	157
CircNDC80 promotes glioblastoma multiforme tumorigenesis via the miR-139-5p/ECE1 pathway	156
Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway	156
Limosilactobacillus reuteri prevents progression of ankylosing spondylitis in mice by restoring gut microbiota-metabolism homeostasis	153
Fully volumetric body composition analysis for prognostic overall survival stratification in melanoma patients	152
Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology	136
Novel models by machine learning to predict prognosis of breast cancer brain metastases	135
Precision information extraction for rare disease epidemiology at scale	132
MicroRNA-24-3p targeting Top1 in perirenal fat is involved in circulating inflammation and high cardiovascular disease risk in patients with primary aldosteronism	130
Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics	128
KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients	126
High VSX1 expression promotes the aggressiveness of clear cell renal cell carcinoma by transcriptionally regulating FKBP10	126
Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation	125
The innovative checkpoint inhibitors of lung adenocarcinoma, cg09897064 methylation and ZBP1 expression reduction, have implications for macrophage polarization and tumor growth in lung cancer	124

Deciphering USP8’s pivotal role in cancer: mechanisms, clinical insights and contrasts with its function in pituitary adenomas	122
Pretreatment of UC-MSCs with IFN-α2 improves treatment of liver fibrosis by recruiting neutrophils	122
Current perspectives in obesity management: unraveling the impact of different therapy approach in real life obesity care	122
Correction: Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation	122
Correction to: Augmentation of tumor expression of HLADR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses	122
Comprehensive analysis of microglia gene and subpathway signatures for glioma prognosis and drug screening: linking microglia to glioma	120
Microplastics as an emerging driver of osteoarthritis: a translational synthesis of environmental exposure, patho-mechanisms, and public health implications	119
Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis	114
Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance	114
The interplay between driver mutation and oxidative stress in colorectal cancer: from pathogenesis to therapeutics	111
An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway	110
The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases	110
Discovery of novel JAK1 inhibitors through combining machine learning, structure-based pharmacophore modeling and bio-evaluation	109
Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease	107
Establishment and validation of predictive model of ARDS in critically ill patients	107
Immune-related lncRNAs signature and radiomics signature predict the prognosis and immune microenvironment of glioblastoma multiforme	106
Gender differences in eating habits and sports preferences across age groups: a cross-sectional study	105
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation	101
Unleashing endogenous regeneration by senolytics	101
Validity between dual-energy x-ray absorptiometry and bioelectrical impedance for segmental fat analysis and a novel low-cost model developed using anthropometry in young adults	100
Lactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a healthy porcine model	99
Weighted gene coexpression network analysis and machine learning reveal oncogenome associated microbiome plays an important role in tumor immunity and prognosis in pan-cancer	99
Biological tissue engineering for Fontan failure using decellularized extracellular matrix: a systematic review	99
Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia	99
The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression	98
Immunogenicity of adalimumab in patients with noninfectious uveitis based on therapeutic drug monitoring	95
WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis	94
SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia	94
Emerging therapeutic strategies for unmet need in neovascular age-related macular degeneration	93
Dual immunosuppression mechanism induced by PTP1B in colorectal cancer: upregulation of PD-L1 by FOXO1/miR-34C/c-MYC axis and inhibition of the infiltration of CD8(+) T cell by downregulating of CXCL1	93
Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: a randomized double- blinded and placebo-controlled trial	93
m6A RNA modification and its emerging roles in diseases: recent advances and therapeutic implications	92
Targeting macrophages: a novel treatment strategy in solid tumors	92
Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer	89
Exploring TNFR1: from discovery to targeted therapy development	88
Vorinostat impairs the cancer-driving potential of leukemia-secreted extracellular vesicles	88
Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma	88
Computational pathology approach for assessment of prognosis and immunotherapy response in pan-gastrointestinal cancer	88
Associations of types of grains and lifestyle with all-cause mortality among Chinese adults aged 65 years or older: a prospective cohort study	87
A 3-tier information fusioned framework featuring explainable deep active optimized CRNet for accurate heart disease prediction	87
B cell pathways implicate shared genetic architecture between schizophrenia and immune-mediated diseases	86
Dietary patterns, polygenic risk, and kidney cancer incidence: a UK Biobank cohort study	86
Accumulated β-catenin is associated with human atrial fibrosis and atrial fibrillation	85
SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner	83
Incidence and immunomic features of apyretic COVID-19 in patients affected by solid tumors: a prospective cohort study	83
Advances in gene therapy for mitochondrial genetic disorders: current status and clinical implementation challenges	83
Myomedin variants developed for in vitro PD-L1 diagnostics in tissue samples of non-small cell lung carcinoma patients	83
Maternal DNA methylation signatures of gestational diabetes across all stages of pregnancy	83
Engineered macrophage membrane-coated dihydroartemisinin nanoparticles with enhanced CCR2 expression improved symptoms in MRL/LPR mice by metabolic reprogramming of proinflammatory macrophages	82
A call to reignite the revolutionary spirit of scientific discovery	82

Prognosis-Related Nutritional Score for Cancer Patients (PRNS): a clinical nutritional score derived from a retrospective cohort study	81
Arginine-linked HPV-associated E7 displaying bacteria-derived outer membrane vesicles as a potent antigen-specific cancer vaccine	80
Single-cell RNA sequencing reveals a B cell-related immunosuppressive landscape and a potential suppressor in hepatocellular carcinoma	80
Gut microbiota analysis and LC-MS-based metabolomics to investigate AMPK/NF-κB regulated by Clostridium butyricum in the treatment of acute pancreatitis	79