OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Translational Medicine is 64. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Comprehensive analysis of microglia gene and subpathway signatures for glioma prognosis and drug screening: linking microglia to glioma	223
Correction: NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway	213
Dissecting transcription of the 8q24-MYC locus in prostate cancer recognizes the equilibration between androgen receptor direct and indirect dual-functions	205
A critical evaluation of berberine in NAFLD management: recommendations for improved research methodology	187
Gut microbiota analysis and LC-MS-based metabolomics to investigate AMPK/NF-κB regulated by Clostridium butyricum in the treatment of acute pancreatitis	175
From sensitivity to public health: integrating cfMeDIP-seq into early breast cancer detection strategies	175
The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation	156
MicroRNA-24-3p targeting Top1 in perirenal fat is involved in circulating inflammation and high cardiovascular disease risk in patients with primary aldosteronism	155
Correction to: Augmentation of tumor expression of HLADR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses	139
A bispecific antibody AP203 targeting PD-L1 and CD137 exerts potent antitumor activity without toxicity	124
Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: a randomized double- blinded and placebo-controlled trial	122
Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification	120
Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer	118
Analysis of thyroid carcinoma composition and spatial architecture in the progression of dedifferentiation, lymphatic metastasis, and gastric metastasis	117
Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers	114
Alterations in whole muscle quality and physiological cross-sectional area measured with quantitative MRI following ACL injury	113
Limosilactobacillus reuteri prevents progression of ankylosing spondylitis in mice by restoring gut microbiota-metabolism homeostasis	108
Effects of prebiotics and phytochemicals on serum trimethylamine N-oxide reduction and gut microbiota: a systematic review and meta-analysis	106
USP5-Mediated PD-L1 deubiquitination regulates immunotherapy efficacy in melanoma	106
Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian popul	105
Precision information extraction for rare disease epidemiology at scale	105
Identification of comutation in signaling pathways to predict the clinical outcomes of immunotherapy	103
The interplay between driver mutation and oxidative stress in colorectal cancer: from pathogenesis to therapeutics	103
Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance	102
Vorinostat impairs the cancer-driving potential of leukemia-secreted extracellular vesicles	101

Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology	101
Correction: Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation	100
SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia	100
Identification of memory B-cell-associated miRNA signature to establish a prognostic model in gastric adenocarcinoma	94
Elevated NGF provokes decidual lipid peroxidation and promotes preterm birth in mice	94
Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics	92
Accumulated β-catenin is associated with human atrial fibrosis and atrial fibrillation	91
Membrane progesterone receptor α (mPRα) enhances hypoxia-induced vascular endothelial growth factor secretion and angiogenesis in lung adenocarcinoma through STAT3 signaling	91
Associations of types of grains and lifestyle with all-cause mortality among Chinese adults aged 65 years or older: a prospective cohort study	89
Myomedin variants developed for in vitro PD-L1 diagnostics in tissue samples of non-small cell lung carcinoma patients	86
A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment	85
Engineered macrophage membrane-coated dihydroartemisinin nanoparticles with enhanced CCR2 expression improved symptoms in MRL/LPR mice by metabolic reprogramming of proinflammatory macrophages	85
High VSX1 expression promotes the aggressiveness of clear cell renal cell carcinoma by transcriptionally regulating FKBP10	84
Discovery of novel JAK1 inhibitors through combining machine learning, structure-based pharmacophore modeling and bio-evaluation	82
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation	81
Cell–cell communications shape tumor microenvironment and predict clinical outcomes in clear cell renal carcinoma	78
The innovative checkpoint inhibitors of lung adenocarcinoma, cg09897064 methylation and ZBP1 expression reduction, have implications for macrophage polarization and tumor growth in lung cancer	78
Establishment and validation of predictive model of ARDS in critically ill patients	77
LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer	76
Disruption of C/EBPβ-Clec7a axis exacerbates neuroinflammatory injury via NLRP3 inflammasome-mediated pyroptosis in experimental neuropathic pain	76
Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer	75
Enhanced cytotoxicity against cholangiocarcinoma by fifth-generation chimeric antigen receptor T cells targeting integrin αvβ6 and secreting anti-PD-L1 scFv	73
Prognosis-Related Nutritional Score for Cancer Patients (PRNS): a clinical nutritional score derived from a retrospective cohort study	73
KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients	73
Gender differences in eating habits and sports preferences across age groups: a cross-sectional study	73
Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway	73
A novel model for predicting prolonged stay of patients with type-2 diabetes mellitus: a 13-year (2010–2022) multicenter retrospective case–control study	72
Fully volumetric body composition analysis for prognostic overall survival stratification in melanoma patients	72
Current perspectives in obesity management: unraveling the impact of different therapy approach in real life obesity care	71
Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia	71
Colonization of fecal microbiota from patients with neonatal necrotizing enterocolitis exacerbates intestinal injury in germfree mice subjected to necrotizing enterocolitis-induction protocol via alte	71
A call to reignite the revolutionary spirit of scientific discovery	70
Advancing polytrauma care: developing and validating machine learning models for early mortality prediction	67
Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation	67
Polygenic risk score of metabolic dysfunction-associated steatotic liver disease amplifies the health impact on severe liver disease and metabolism-related outcomes	66
Global research trends on the links between the gut microbiome and cancer: a visualization analysis	66
Magnetique: an interactive web application to explore transcriptome signatures of heart failure	65
Validity between dual-energy x-ray absorptiometry and bioelectrical impedance for segmental fat analysis and a novel low-cost model developed using anthropometry in young adults	65
A novel deep learning-based algorithm combining histopathological features with tissue areas to predict colorectal cancer survival from whole-slide images	64
Red blood cell-derived arginase release in hemolytic uremic syndrome	64
Association of vitamin B2 intake with cognitive performance in older adults: a cross-sectional study	64