OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Translational Medicine is 79. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
A critical evaluation of berberine in NAFLD management: recommendations for improved research methodology	357
Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers	288
KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients	241
Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation	194
A call to reignite the revolutionary spirit of scientific discovery	191
Myomedin variants developed for in vitro PD-L1 diagnostics in tissue samples of non-small cell lung carcinoma patients	185
Associations of types of grains and lifestyle with all-cause mortality among Chinese adults aged 65 years or older: a prospective cohort study	175
CircNDC80 promotes glioblastoma multiforme tumorigenesis via the miR-139-5p/ECE1 pathway	172
Precision information extraction for rare disease epidemiology at scale	170
Correction: NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway	168
From sensitivity to public health: integrating cfMeDIP-seq into early breast cancer detection strategies	166
A 3-tier information fusioned framework featuring explainable deep active optimized CRNet for accurate heart disease prediction	163
Correction to: Augmentation of tumor expression of HLADR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses	160
Correction: Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation	158
Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1	153
Identification of comutation in signaling pathways to predict the clinical outcomes of immunotherapy	153
Silencing PinX1 enhances radiosensitivity and antitumor-immunity of radiotherapy in non-small cell lung cancer	145
Assessing the causal effect of genetically predicted metabolites and metabolic pathways on stroke	142
A bispecific antibody AP203 targeting PD-L1 and CD137 exerts potent antitumor activity without toxicity	139
Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance	138
Biological tissue engineering for Fontan failure using decellularized extracellular matrix: a systematic review	135
Dissecting transcription of the 8q24-MYC locus in prostate cancer recognizes the equilibration between androgen receptor direct and indirect dual-functions	134
Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2 pathway	133
m6A RNA modification and its emerging roles in diseases: recent advances and therapeutic implications	132
Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease	131

A novel model for predicting prolonged stay of patients with type-2 diabetes mellitus: a 13-year (2010–2022) multicenter retrospective case–control study	127
Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma	127
Prognosis-Related Nutritional Score for Cancer Patients (PRNS): a clinical nutritional score derived from a retrospective cohort study	124
Engineered macrophage membrane-coated dihydroartemisinin nanoparticles with enhanced CCR2 expression improved symptoms in MRL/LPR mice by metabolic reprogramming of proinflammatory macrophages	123
Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations	118
Magnetique: an interactive web application to explore transcriptome signatures of heart failure	118
Clinical impact of volume of disease and time of metastatic disease presentation on patients receiving enzalutamide or abiraterone acetate plus prednisone as first-line therapy for metastatic castrati	117
B cell pathways implicate shared genetic architecture between schizophrenia and immune-mediated diseases	116
Radiogenomic MRI biomarkers for noninvasive prediction of GPC3 expression and tumor microenvironment in hepatocellular carcinoma	115
Unlocking the potential of EphA2 with precision-guided cancer therapy: bicycle drug conjugates	115
Maternal DNA methylation signatures of gestational diabetes across all stages of pregnancy	114
Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma	113
Pretreatment of UC-MSCs with IFN-α2 improves treatment of liver fibrosis by recruiting neutrophils	113
Association of vitamin B2 intake with cognitive performance in older adults: a cross-sectional study	112
Chronic liver diseases aggravate radiation-induced intestinal injury through taurocholic acid dysregulation	111
Elevated NGF provokes decidual lipid peroxidation and promotes preterm birth in mice	111
Molecular imaging in gastric cancer: state-of-the-art techniques and emerging opportunities	110
Two-sample Mendelian Randomization to evaluate the causal relationship between inflammatory arthritis and female-specific cancers	109
Vorinostat impairs the cancer-driving potential of leukemia-secreted extracellular vesicles	109
Accumulated β-catenin is associated with human atrial fibrosis and atrial fibrillation	107
Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: a randomized double- blinded and placebo-controlled trial	107
Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis	105
Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis	104
RAD21 regulation of the enhancer–promoter chromatin loop of RAD51 promotes PARPi resistance in ovarian cancer	104
The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression	103
High VSX1 expression promotes the aggressiveness of clear cell renal cell carcinoma by transcriptionally regulating FKBP10	103
Establishment and validation of predictive model of ARDS in critically ill patients	99
Unleashing endogenous regeneration by senolytics	98
Translational potential of GMP-grade human umbilical cord-derived mesenchymal stem cells (UC-MSCs) in traumatic spinal cord injury: a preclinical study in rat	98
Peroxynitrite regulates ER stress-mediated Ca2+ flux to mitochondria characterizing cardiac microvascular ischemia–reperfusion injury associated with hyperhomocysteinemia	98
Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition	98
Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian popul	97
Multiomics prediction and immunogenic validation of personalized neoantigens in cholangiocarcinoma patients	97
Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance	96
An enhanced-permeability amphiphilic nanogel loaded with sulforaphane for synergistic anti-oxidative and anti-ferroptotic therapy of corneal alkali burn	95
Lactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a healthy porcine model	95
Dual immunosuppression mechanism induced by PTP1B in colorectal cancer: upregulation of PD-L1 by FOXO1/miR-34C/c-MYC axis and inhibition of the infiltration of CD8(+) T cell by downregulating of CXCL1	95
Deciphering USP8’s pivotal role in cancer: mechanisms, clinical insights and contrasts with its function in pituitary adenomas	93
Red blood cell-derived arginase release in hemolytic uremic syndrome	92
Single-cell RNA sequencing reveals a B cell-related immunosuppressive landscape and a potential suppressor in hepatocellular carcinoma	92
Advancing polytrauma care: developing and validating machine learning models for early mortality prediction	91
Targeting macrophages: a novel treatment strategy in solid tumors	91
Removal of aging microenvironment of bone defects can effectively promote bone defect repair	91
Protectin conjugates in tissue regeneration 1 alleviates sepsis-induced acute lung injury by inhibiting ferroptosis	90
Lower airway transcriptome signatures in asthma: a newly described cytokine C10orf99 identification	89
The Swedish childhood tumor biobank: systematic collection and molecular characterization of all pediatric CNS and other solid tumors in Sweden	89
Weighted gene coexpression network analysis and machine learning reveal oncogenome associated microbiome plays an important role in tumor immunity and prognosis in pan-cancer	88
Analysis of thyroid carcinoma composition and spatial architecture in the progression of dedifferentiation, lymphatic metastasis, and gastric metastasis	85
USP5-Mediated PD-L1 deubiquitination regulates immunotherapy efficacy in melanoma	83
Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification	82

Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia	82
The innovative checkpoint inhibitors of lung adenocarcinoma, cg09897064 methylation and ZBP1 expression reduction, have implications for macrophage polarization and tumor growth in lung cancer	81
Functional regulation of GlycoRNA and progress in malignant tumors	79
Pancreatic organoids and organoid-on-a-chip platforms: from disease modeling to precision therapy	79