Cell Communication and Signaling

Article	Citations
Polydatin upregulates ZDHHC19 to promote apoptosis of acute myeloid leukemia cells via mediating BID palmitoylation	645
Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation	576
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish	412
Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling	393
Catalase-deficient mice induce aging faster through lysosomal dysfunction	382
Chondroitin sulfate E activates IL-6/STAT3 signaling to drive androgen-independent growth in castration-resistant prostate cancer	353
MSP-RON signaling in liver pathobiology and as an emerging therapeutic target: a review of the current evidence	278
Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation	217
Primary ciliogenesis is promoted during epithelial-mesenchymal transition via a miR-200 – DZIP1 axis	192
The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor	187
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells	169
Epigenetic regulation of NR5A2 influences colorectal cancer cell stemness via a stemness-related transcription factor NANOG	169
Extracellular vesicles derived from Enterococcus faecalis: inflammatory activation does not require internalization	167
RT–ICI therapy induces a distal immunometabolic axis that shapes systemic macrophage polarization and enhances local T cell immunity	164
The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice	151
Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress	148
Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer	148
The aberration of key amino acids participated one-carbon metabolism may jeopardize genetic stability in cancer development	146
LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence	143
Tannic acid inhibits TNF-α signaling by targeting the protein disulfide isomerase and alleviates symptoms in an imiquimod-induced psoriasis mouse model	141
UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1	139
The p53 tumor suppressor modulates the expression of proteins that control natural killer cell activity	139
Harnessing nanomedicine to target NF-κB signalling in cancer: at the intersection of inflammatory signalling, metabolic reprogramming, and therapeutic innovation	129
STIM–Orai signaling in neurons: integrating calcium dynamics and synaptic plasticity	127
Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis	126

USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice	123
Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage	122
Epigenetic meets metabolism: novel vulnerabilities to fight cancer	120
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury	118
Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth	118
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases	118
RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma	110
SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells	108
Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2	106
Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells	104
Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2	103
New insights into the regulation of METTL3 and its role in tumors	99
Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment	99
Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis	97
Mitochondrial dysfunction in the regulation of aging and aging-related diseases	97
Transmission Electron Microscopy-based characterization of Extracellular Vesicles from plasma and serum from Parkinson´s Disease patients	97
The scaffold protein AXIN1: gene ontology, signal network, and physiological function	93
Fibroblast growth factor receptor substrate 2 interactome mapping reveals novel candidate interactors associated with migration and invasion	91
Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis	90
The mevalonate and methylerythritol phosphate pathways as therapeutic targets in protozoan parasites: from moonlighting enzymes to metabolic plasticity	90
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC	90
RNA N6-methyladenosine modification in female reproductive biology and pathophysiology	88
Phase separation-mediated biomolecular condensates and their relationship to tumor	87
Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases	86
Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition	85
Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression	84
Exosome RAB10 inhibits JAK1/STAT1 to hinder macrophage M1 polarization and promote tumor immune escape	83
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress	82
Periprostatic adipose tissue-derived adipokine profile in prostate cancer patients reveals two distinct molecular phenotypes linked to obesity-related comorbidities: multifaceted role of lipocalin-2	80
STAT3 blockade ameliorates LPS-induced kidney injury through macrophage-driven inflammation	79
MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis	77
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis	77
The role of lactate in cardiovascular diseases	77
Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease	76
Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells	76
Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2α/ATF4/CHOP and secretory autophagy pathways	75
STING-ERO1 signaling exacerbates PARylation-mediated parthanatos in sepsis	75
Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress	74
The critical role of necroptosis in oil cyst formation associated with autologous fat transplantation	74
Organ-Specific Migration License (OSML) theory: a novel paradigm for spatiotemporal regulation and intervention of cross-organ immune cell migration in tumor immune responses	74
STING-STAT1-ZBP1 axis orchestrates PANoptotic signaling in ischemia-reperfusion induced acute kidney injury	72
Role of DEAD/DEAH-box helicases in immunity, infection and cancers	71
SIRT6 cooperates with KDM5C to transcriptionally silence MICAL2 and inhibit tumorigenesis in pancreatic cancer	71
Melanoma stimulates the proteolytic activity of HaCaT keratinocytes	70
Correction: MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer	69
C-terminal tail of MAVS dictates organelle targeting and innate immune response	69
TGFβ1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli	68
Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach	68
Correction: LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure	67
Correction: The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities	67

Terphenyllin induces CASP3-dependent apoptosis and pyroptosis in A375 cells through upregulation of p53	67
Intrauterine administration of peripheral blood mononuclear cells helps manage recurrent implantation failure by normalizing dysregulated gene expression including estrogen-responsive genes in mice	67
Dual inhibition of GTP-bound KRAS and mTOR in lung adenocarcinoma and squamous cell carcinoma harboring KRAS G12C	66
Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression	64
The primary cilium as a multifunctional organelle: emerging roles and unanswered questions	64
Roles of Twist1 in lipid and glucose metabolism	64
E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3Rα	64
Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis	63
A pro-carcinogenic oral microbe internalized by breast cancer cells promotes mammary tumorigenesis	63
HAX1 inhibits apoptosis and promotes maturation of neutrophils	63
Castration promotes the browning of the prostate tumor microenvironment	63
Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-γ and exerts a therapeutic effect in abortion-prone m	62
Bacterial extracellular vesicles modulate epithelial antiviral responses via macrophage-mediated immunomodulation	62
Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction	61
Precise metabolomics identifies glycolysis-related pyruvate kinase M activity as regulator of the S-phase-specific radiation response in triple-negative breast cancer cells	60
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer	60
The roles of different microRNAs in the regulation of cholesterol in viral hepatitis	60
Dual targeting of interlocked PTK2B and MAPK signaling triggers synergistic ferroptosis via autophagic flux disruption in BRAFV600E glioma	59
ARNT2 repression disrupts neuronal identity and promotes glioblastoma growth	59
Opposing effects of Rho-associated coiled-coil kinase 1 (ROCK1) and ROCK2 in TGF-β-SMAD signaling	59
Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice	58
O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology	58
S100A9 lactylation facilitated sepsis-related acute respiratory distress syndrome via promoting transcription activation of IL-1β in macrophages	58
Microglial depletion decreases Müller cell maturation and inner retinal vascular density	58
Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML	58
RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter	58
Functionalized exosomes for targeted therapy in cancer and regenerative medicine: genetic, chemical, and physical modifications	57
LRSAM1 mediated the degradation of intracellular Vibrio through the ubiquitination-autophagy-lysosome pathway in oyster	56
The dual role of the microbiome in chronic wound management	56
Neuronal tetraspanin TSP-6 suppresses intestinal innate immunity by modulating dense-core vesicle release in Caenorhabditis elegans	55
Postbiotics as microbial-derived therapeutics for wound healing disorders: from molecular mechanisms to future application	55
Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion	55
GLUT1 promotes cell proliferation via binds and stabilizes phosphorylated EGFR in lung adenocarcinoma	54
MOTS-c attenuates placental vascular endothelial cell apoptosis in intrahepatic cholestasis of pregnancy by inhibiting K33-linked deubiquitination of BACH1	54
Correction: Human Parathyroid Hormone Analog (3–34/29–34) promotes wound re-epithelialization through inducing keratinocyte migration and epithelial–mesenchymal transition via PTHR1-PI3K/AKT activatio	54
IL-23 promotes neuronal ferroptosis via IL-23R/STAT3 signaling after traumatic brain injury	54
The role of miR-155-5p in inflammation and mechanical loading during intervertebral disc degeneration	53
Evidence that CRISPR-Cas9 Y537S-mutant expressing breast cancer cells activate Yes-associated protein 1 to driving the conversion of normal fibroblasts into cancer-associated fibroblasts	53
Mitochondria facilitate neuronal differentiation by metabolising nuclear-encoded RNA	53
IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways	53
Fibroblast-derived POSTN promotes colorectal cancer progression under high-fat diet by reprogramming fatty acid metabolism in tumor cell	53
Nanobodies and their derivatives: pioneering the future of cancer immunotherapy	52
The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis	52
NAT10 mediated ac4C acetylation driven m6A modification via involvement of YTHDC1-LDHA/PFKM regulates glycolysis and promotes osteosarcoma	52
Role of liver sinusoidal endothelial cell in metabolic dysfunction-associated fatty liver disease	52
U2AF2-regulated alternative splicing of UPP1 promotes NSCLC progression by enhancing glycolysis	52
Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1	52
The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology	51
Natural killer cells and their exosomes in viral infections and related therapeutic approaches: where are we?	51
Andrew H. Wyllie, a pioneer in the field of apoptosis	51
OTU deubiquitinase, ubiquitin aldehyde binding 2  (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (	50
The role of KLRG1: a novel biomarker and new therapeutic target	50
R-loops and D-loops: a delicate balance in genomic stability and instability	48
Cellular crosstalk in atherosclerotic plaque microenvironment	48
Mitochondria and the epigenome: maternal co-inheritance and crosstalk from oocyte to embryo	47
PGC7 regulates maternal mRNA translation via AKT1-YBX1 interactions in mouse oocytes	47
The neuro-vascular-immune triad: the interactive network in the tumor microenvironment	47
Non-canonical non-genomic morphogen signaling in anucleate platelets: a critical determinant of prothrombotic function in circulation	47
Campylobacter jejuni regulates cell cycle progression to potentiate host cell invasion	47
The cellular economy while crafting regulatory processes relies on protein intrinsic disorder: how and why precision comes at a cost in protein structure	47
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated mitophagy	47
Beyond the G protein α subunit: investigating the functional impact of other components of the Gαi3 heterotrimers	46
Semaphorin3f as a cardiomyocyte derived regulator of heart chamber development	46
Correction: MicroRNA-644a promotes apoptosis of hepatocellular carcinoma cells by downregulating the expression of heat shock factor 1	46
Cancer-associated adipocytes promote peritoneal metastasis of colorectal signet ring cell carcinoma via FABP4 induction	46
N88S seipin-related seipinopathy is a lipidopathy associated with loss of iron homeostasis	45
IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A	45
Tumor-derived miR-6794-5p enhances cancer growth by promoting M2 macrophage polarization	45
Design of stable circular permutants of the GroEL chaperone apical domain	45
Celecoxib inhibits COX-2 and initiates YAP-dependent mitochondrial apoptosis via YBX1 shuttling in hepatocellular carcinoma	45
Correction: Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis	45
Combination therapy strategies in engineered 177Lu radiopharmaceuticals beyond single modality: design principles and application outlet	45
Emerging roles and biomarker potential of WNT6 in human cancers	45
Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis	44
Targeting of specific CCR5-G protein complexes underlies biased signaling by HIV-1 envelope glycoproteins	44
NOTCH3 Mutations in CADASIL: a multicellular perspective on neurodegeneration	44
Outcomes of physical exercises on initiation, progression, and treatment of breast cancer	44
Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo	44
Characterization of two melanoma cell lines resistant to BRAF/MEK inhibitors (vemurafenib and cobimetinib)	44
Sirtuins in kidney diseases: potential mechanism and therapeutic targets	44

Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1	44
Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H2O2-dependent manner	43
Extracellular vesicles in Helicobacter pylori-mediated diseases: mechanisms and therapeutic potential	43
Lactylation in cancer: a new frontier in metabolic-epigenetic regulation and clinical practice	43
Exosome-transmitted HSPA9 facilitates bortezomib resistance by targeting TRIP13/USP1 signaling in multiple myeloma	43
Lactate shuttle between cytotrophoblast and syncytiotrophoblast in the placenta enhances ferroptosis resistance and maintains placental homeostasis: implications for early pregnancy loss	43
Antizyme inhibitor family: biological and translational research implications	43
Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction	43
Gonad–soma inter-tissue communication alleviates ultraviolet-induced neurotoxicity in C. elegans	43
Cellular and micro-environmental responses influencing the antitumor activity of all-trans retinoic acid in breast cancer	43
Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections	43
Kynurenine-AhR-SLC39A10-Zn2+ signaling reprograms macrophages and enhances pirfenidone efficacy in pulmonary fibrosis	43
Targeting endolysosomal acidification inhibits poxvirus entry and replication	43
Chitinase-3-like protein 1 depletion in glioma cells alters tumor microenvironment and normalizes neovasculature in human glioma xenografts	42
Retinal pigment epithelium-derived extracellular vesicles mediate outer blood retinal barrier disruption in response to AMD-related stress	42
Activity-based proteomics analysis revealed that DNJ directly targeted ATP5F1 to alleviate high glucose induced cardiomyocyte injury	42
The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion	42
Acidic preconditioning induced intracellular acid adaptation to protect renal injury via dynamic phosphorylation of focal adhesion kinase-dependent activation of sodium hydrogen exchanger 1	41
Rhythmic-phasic c-di-AMP signaling: a new paradigm for bacterial growth synchronization governed by a pseudo-phosphodiesterase and modifiable diadenylate cyclase	41
cGAS-STING, inflammasomes and pyroptosis: an overview of crosstalk mechanism of activation and regulation	41
Pyroptosis, ferroptosis, and autophagy cross-talk in glioblastoma opens up new avenues for glioblastoma treatment	41
β-cell adaptation to increased insulin demand is a swift and dynamic process orchestrated by unfolded protein response	41
Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression	41
Glycosylation as an intricate post-translational modification process takes part in glycoproteins related immunity	40
Trogocytosis in CAR immune cell therapy: a key mechanism of tumor immune escape	40
Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets	40
The significant role of amino acid metabolic reprogramming in cancer	40
Neutrophil extracellular traps promote angiogenesis in gastric cancer	40
Elucidating the molecular mechanisms underlying the induction of autophagy by antidepressant-like substances in C57BL/6J mouse testis model upon LPS challenge	39
Plasma circulating extracellular vesicles reveal dysregulation of synaptic signaling in SHIV-infected rhesus macaque	39
eNAMPT/TLR4 signaling drives PAH cellular phenotypic switching and lung vascular remodeling	39
Frizzled class receptor 5 contributes to ovarian cancer chemoresistance through aldehyde dehydrogenase 1A1	39
Neutrophil extracellular traps released by CD177+ neutrophils aggravated inflammation and neuronal impairment post-SCI	39
Correction: Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis	39
Correction: Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome	39
Cytoplasmic retention of IRF3 binding Vimentin competitively with ERK1/2 mitigates acute myeloid leukemia through TFEB nuclear translocation	38
The cancer-associated fibroblast facilitates YAP liquid-liquid phase separation to promote cancer cell stemness in HCC	38
Distinct roles of centriole distal appendage proteins in ciliary assembly and disassembly	38
Novel energy optimizer, meldonium, rapidly restores acute hypobaric hypoxia-induced brain injury by targeting phosphoglycerate kinase 1	38
Docetaxel suppressed cell proliferation through Smad3/HIF-1α-mediated glycolysis in prostate cancer cells	38
From cell lines to the clinic: identifying a urinary BlCa-EV signature through comparative proteomics of bladder cancer lysates and extracellular vesicles	38
Targeting Endocytosis  and Cell Communications  in the Tumor Immune Microenvironment	38
Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo	38
Mitochondria-derived vesicles serve as reactors in response to stress in cardiomyocytes	38
A novel extracellular flux assay workflow uncovers impaired sciatic nerve mitochondrial respiration in diabetic db/db mice	37
Emerging roles of liquid-liquid phase separation in liver innate immunity	37
Selective Pyk2 inhibition enhances bone restoration through SCARA5-mediated bone marrow remodeling in ovariectomized mice	37
Bacteria-derived glutarate mitigates Alzheimer’s disease model pathology through autophagy-lysosomal pathway	37
An attempt to explain what intrinsically disordered TCF4 does in its spare time when PTHS-related mutations prevent it from doing its job	37
IL-15 promotes immune escape, invasion, and metastasis of pancreatic cancer by upregulating PD-L1 expression via the JAK1/STAT1/IRF1 pathway	37
Nuclear import of Mas-related G protein-coupled receptor member D induces pathological cardiac remodeling	37
P2X7 is an important mediator of BMP9-induced osteogenic differentiation of mesenchymal stem cells	37
CRABP1-complexes in exosome secretion	37
Macrophages sense and follow physiologically relevant K+ and Na+ gradients: how induced dipoles and ionotaxis may explain electrotaxis	37
NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression	37
A non-classical necroptosis pathway mediated by caspases	36
The heterogeneity of monocyte-derived macrophages in MASH pathogenesis	36
Co-culture engineering: a promising strategy for production of engineered extracellular vesicle for osteoarthritis treatment	36
Whole-gene CRISPR/cas9 library screen revealed targeting STAT6 increased the sensitivity of liver cancer to celecoxib via inhibiting arachidonic acid shunting	36
Change in cytokine profiles released by mast cells mediated by lung cancer-derived exosome activation may contribute to cancer-associated coagulation disorders	35
Arginyltransferase 1 modulates p62-driven autophagy via mTORC1/AMPk signaling	35
Upregulated FSP1 by GPD1/1L mediated lipid droplet accumulation enhances ferroptosis resistance and peritoneal metastasis in gastric cancer	35
Cancer immune evasion through KRAS and PD-L1 and potential therapeutic interventions	35
Metrnl: a promising biomarker and therapeutic target for cardiovascular and metabolic diseases	35
Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells	35
Programmed cell death disrupts inflammatory tumor microenvironment (TME) and promotes glioblastoma evolution	35
Unraveling the role of hypoxia-inducible factors in cutaneous melanoma: from mechanisms to therapeutic opportunities	35
Targeting the mevalonate pathway sensitizes multiple myeloma cells to bortezomib through induction of mitochondrial metabolic disruption	35
Therapeutic targeting of the TPX2/TTK network in colorectal cancer	34
Multiomics analysis revealed the mechanisms related to the enhancement of proliferation, metastasis and EGFR-TKI resistance in EGFR-mutant LUAD with ARID1A deficiency	34
The CD6 interactome orchestrates ligand-independent T cell inhibitory signaling	34
A bispecific-aptamer TSHR-CD80-1 treats thyroid eye disease by inhibiting CD8+ T cell-fibroblast interactions	34
Kaempferol-modified mesenchymal stem cell extracellular vesicle-mimetics promote photoaging repair by suppressing ADAM10	34
Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain	34
Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling	34
VprBP drives prostate tumorigenesis by its kinase activity targeting histone H2A	34
c-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment	33
Mitochondrial homeostasis meets novel programmed cell death: crosstalk mechanisms underlying cardiovascular diseases progression	33
Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism	33
The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition	33
Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds	33
Arachidonic acid impairs natural killer cell functions by disrupting signaling pathways driven by activating receptors and reactive oxygen species	33
Photomodulation alleviates cellular senescence of aging adipose-derived stem cells	33
SRY mediates male-specific susceptibility to acute liver injury	33
Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance	33
The impact of lipid metabolism on breast cancer: a review about its role in tumorigenesis and immune escape	33
The efferocytosis dilemma: how neutrophil extracellular traps and PI3K/Rac1 complicate diabetic wound healing	33
IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors	33
An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in Candida albicans during host infection	32
ATP purinergic receptor signalling promotes Sca-1+ cell proliferation and migration for vascular remodelling	32
IL-33-mediated activation of mast cells is involved in the progression of imiquimod-induced psoriasis-like dermatitis	32
Cerebral Semaphorin3D is a novel risk factor for age-associated cognitive impairment	32
Post-traumatic stress disorder impairs CD8+ T cell-dependent anti-tumor immune responses by downregulating thiamine	32
Enhancing intestinal epithelial microtubule stability could alleviate IBD symptoms	32
Immunosuppressants rewire the gut microbiome-alloimmune axis through time-dependent and tissue-specific mechanisms	32