OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Communication and Signaling is 69. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-07-01 to 2026-07-01.)

Article	Citations
Polydatin upregulates ZDHHC19 to promote apoptosis of acute myeloid leukemia cells via mediating BID palmitoylation	619
SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells	570
Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation	393
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish	379
RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma	367
Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition	338
Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells	258
Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling	211
Catalase-deficient mice induce aging faster through lysosomal dysfunction	199
Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression	185
Chondroitin sulfate E activates IL-6/STAT3 signaling to drive androgen-independent growth in castration-resistant prostate cancer	181
Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth	161
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC	161
Exosome RAB10 inhibits JAK1/STAT1 to hinder macrophage M1 polarization and promote tumor immune escape	160
MSP-RON signaling in liver pathobiology and as an emerging therapeutic target: a review of the current evidence	155
Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation	143
Primary ciliogenesis is promoted during epithelial-mesenchymal transition via a miR-200 – DZIP1 axis	143
Epigenetic regulation of NR5A2 influences colorectal cancer cell stemness via a stemness-related transcription factor NANOG	140
The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor	140
Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis	137
The aberration of key amino acids participated one-carbon metabolism may jeopardize genetic stability in cancer development	137
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells	130
Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2	130
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases	122
Extracellular vesicles derived from Enterococcus faecalis: inflammatory activation does not require internalization	121

RT–ICI therapy induces a distal immunometabolic axis that shapes systemic macrophage polarization and enhances local T cell immunity	120
The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice	119
Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2	118
Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress	113
Fibroblast growth factor receptor substrate 2 interactome mapping reveals novel candidate interactors associated with migration and invasion	113
Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer	111
Tannic acid inhibits TNF-α signaling by targeting the protein disulfide isomerase and alleviates symptoms in an imiquimod-induced psoriasis mouse model	109
UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1	109
Transmission Electron Microscopy-based characterization of Extracellular Vesicles from plasma and serum from Parkinson´s Disease patients	105
Harnessing nanomedicine to target NF-κB signalling in cancer: at the intersection of inflammatory signalling, metabolic reprogramming, and therapeutic innovation	102
LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence	101
The p53 tumor suppressor modulates the expression of proteins that control natural killer cell activity	97
The scaffold protein AXIN1: gene ontology, signal network, and physiological function	96
Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment	95
Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis	93
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury	93
Periprostatic adipose tissue-derived adipokine profile in prostate cancer patients reveals two distinct molecular phenotypes linked to obesity-related comorbidities: multifaceted role of lipocalin-2	91
New insights into the regulation of METTL3 and its role in tumors	90
Phase separation-mediated biomolecular condensates and their relationship to tumor	89
Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage	87
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress	85
Epigenetic meets metabolism: novel vulnerabilities to fight cancer	85
RNA N6-methyladenosine modification in female reproductive biology and pathophysiology	85
Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases	83
The role of lactate in cardiovascular diseases	83
STAT3 blockade ameliorates LPS-induced kidney injury through macrophage-driven inflammation	81
Mitochondrial dysfunction in the regulation of aging and aging-related diseases	80
Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis	80
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice	78
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis	78
MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis	76
Fibroblast-derived POSTN promotes colorectal cancer progression under high-fat diet by reprogramming fatty acid metabolism in tumor cell	75
Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease	75
Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells	75
RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter	74
Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2α/ATF4/CHOP and secretory autophagy pathways	74
Correction: Human Parathyroid Hormone Analog (3–34/29–34) promotes wound re-epithelialization through inducing keratinocyte migration and epithelial–mesenchymal transition via PTHR1-PI3K/AKT activatio	74
STING-ERO1 signaling exacerbates PARylation-mediated parthanatos in sepsis	73
Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1	72
The critical role of necroptosis in oil cyst formation associated with autologous fat transplantation	71
Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress	70
Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis	69
Role of DEAD/DEAH-box helicases in immunity, infection and cancers	69
Organ-Specific Migration License (OSML) theory: a novel paradigm for spatiotemporal regulation and intervention of cross-organ immune cell migration in tumor immune responses	69