OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Communication and Signaling is 69. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Polydatin upregulates ZDHHC19 to promote apoptosis of acute myeloid leukemia cells via mediating BID palmitoylation	645
Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation	576
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish	412
Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling	393
Catalase-deficient mice induce aging faster through lysosomal dysfunction	382
Chondroitin sulfate E activates IL-6/STAT3 signaling to drive androgen-independent growth in castration-resistant prostate cancer	353
MSP-RON signaling in liver pathobiology and as an emerging therapeutic target: a review of the current evidence	278
Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation	217
Primary ciliogenesis is promoted during epithelial-mesenchymal transition via a miR-200 – DZIP1 axis	192
The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor	187
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells	169
Epigenetic regulation of NR5A2 influences colorectal cancer cell stemness via a stemness-related transcription factor NANOG	169
Extracellular vesicles derived from Enterococcus faecalis: inflammatory activation does not require internalization	167
RT–ICI therapy induces a distal immunometabolic axis that shapes systemic macrophage polarization and enhances local T cell immunity	164
The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice	151
Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress	148
Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer	148
The aberration of key amino acids participated one-carbon metabolism may jeopardize genetic stability in cancer development	146
LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence	143
Tannic acid inhibits TNF-α signaling by targeting the protein disulfide isomerase and alleviates symptoms in an imiquimod-induced psoriasis mouse model	141
UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1	139
The p53 tumor suppressor modulates the expression of proteins that control natural killer cell activity	139
Harnessing nanomedicine to target NF-κB signalling in cancer: at the intersection of inflammatory signalling, metabolic reprogramming, and therapeutic innovation	129
STIM–Orai signaling in neurons: integrating calcium dynamics and synaptic plasticity	127
Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis	126

USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice	123
Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage	122
Epigenetic meets metabolism: novel vulnerabilities to fight cancer	120
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury	118
Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth	118
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases	118
RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma	110
SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells	108
Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2	106
Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells	104
Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2	103
New insights into the regulation of METTL3 and its role in tumors	99
Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment	99
Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis	97
Mitochondrial dysfunction in the regulation of aging and aging-related diseases	97
Transmission Electron Microscopy-based characterization of Extracellular Vesicles from plasma and serum from Parkinson´s Disease patients	97
The scaffold protein AXIN1: gene ontology, signal network, and physiological function	93
Fibroblast growth factor receptor substrate 2 interactome mapping reveals novel candidate interactors associated with migration and invasion	91
Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis	90
The mevalonate and methylerythritol phosphate pathways as therapeutic targets in protozoan parasites: from moonlighting enzymes to metabolic plasticity	90
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC	90
RNA N6-methyladenosine modification in female reproductive biology and pathophysiology	88
Phase separation-mediated biomolecular condensates and their relationship to tumor	87
Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases	86
Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition	85
Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression	84
Exosome RAB10 inhibits JAK1/STAT1 to hinder macrophage M1 polarization and promote tumor immune escape	83
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress	82
Periprostatic adipose tissue-derived adipokine profile in prostate cancer patients reveals two distinct molecular phenotypes linked to obesity-related comorbidities: multifaceted role of lipocalin-2	80
STAT3 blockade ameliorates LPS-induced kidney injury through macrophage-driven inflammation	79
MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis	77
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis	77
The role of lactate in cardiovascular diseases	77
Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease	76
Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells	76
Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2α/ATF4/CHOP and secretory autophagy pathways	75
STING-ERO1 signaling exacerbates PARylation-mediated parthanatos in sepsis	75
Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress	74
The critical role of necroptosis in oil cyst formation associated with autologous fat transplantation	74
Organ-Specific Migration License (OSML) theory: a novel paradigm for spatiotemporal regulation and intervention of cross-organ immune cell migration in tumor immune responses	74
STING-STAT1-ZBP1 axis orchestrates PANoptotic signaling in ischemia-reperfusion induced acute kidney injury	72
Role of DEAD/DEAH-box helicases in immunity, infection and cancers	71
SIRT6 cooperates with KDM5C to transcriptionally silence MICAL2 and inhibit tumorigenesis in pancreatic cancer	71
Melanoma stimulates the proteolytic activity of HaCaT keratinocytes	70
Correction: MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer	69
C-terminal tail of MAVS dictates organelle targeting and innate immune response	69