OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Communication and Signaling is 55. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC	428
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells	327
The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor	324
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress	237
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish	222
Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation	207
Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation	187
Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis	187
MSP-RON signaling in liver pathobiology and as an emerging therapeutic target: a review of the current evidence	178
Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2	169
Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling	148
Transmission Electron Microscopy-based characterization of Extracellular Vesicles from plasma and serum from Parkinson´s Disease patients	138
SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells	136
The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice	132
RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma	124
LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence	113
Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition	104
New insights into the regulation of METTL3 and its role in tumors	102
The scaffold protein AXIN1: gene ontology, signal network, and physiological function	102
Catalase-deficient mice induce aging faster through lysosomal dysfunction	102
Extracellular vesicles from maternal uterine cells exposed to risk factors cause fetal inflammatory response	98
Epigenetic meets metabolism: novel vulnerabilities to fight cancer	94
Phase separation-mediated biomolecular condensates and their relationship to tumor	90
Mitochondrial dysfunction in the regulation of aging and aging-related diseases	90
Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer	89

Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment	89
Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2	86
A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types	84
The role of lactate in cardiovascular diseases	83
Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression	80
Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells	79
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases	79
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury	75
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice	75
Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage	75
UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1	70
Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis	68
Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases	66
RNA N6-methyladenosine modification in female reproductive biology and pathophysiology	65
STAT3 blockade ameliorates LPS-induced kidney injury through macrophage-driven inflammation	64
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis	64
Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis	64
Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges	63
LRSAM1 mediated the degradation of intracellular Vibrio through the ubiquitination-autophagy-lysosome pathway in oyster	62
Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction	62
Correction: LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure	61
Mitochondria facilitate neuronal differentiation by metabolising nuclear-encoded RNA	60
Communication between cells: exosomes as a delivery system in prostate cancer	60
Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress	59
O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology	59
MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis	59
Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1	59
TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis	59
Role of DEAD/DEAH-box helicases in immunity, infection and cancers	57
RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter	56