OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Nanobiotechnology is 85. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Double-layered N-S1 protein nanoparticle immunization elicits robust cellular immune and broad antibody responses against SARS-CoV-2	1509
Transdermal delivery of CRISPR/Cas9-mediated melanoma gene therapy via polyamines-modified thermosensitive hydrogels	348
Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity	279
Protective effect of spore oil-functionalized nano-selenium system on cisplatin-induced nephrotoxicity by regulating oxidative stress-mediated pathways and activating immune response	263
Tumor microenvironment-responsive BSA nanocarriers for combined chemo/chemodynamic cancer therapy	261
Engineered extracellular vesicles-mediated curcumin delivery in brain microenvironment modulating lysosomes, mitochondria, and microglia reprogram for parkinson’s disease therapy	237
Hyaluronic acid-functionalized supramolecular nanophotosensitizers for targeted photoimmunotherapy of triple-negative breast cancer	235
Integrated triple signal amplification strategy for ultrasensitive electrochemical detection of gastric cancer-related microRNA utilizing MoS2-based nanozyme, hybridization chain reaction, and horsera	225
BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma	220
Apoptotic extracellular vesicles act as master regulators of the bone healing niche	216
CPA-Cas12a-based lateral flow strip for portable assay of Methicillin-resistant Staphylococcus aureus in clinical sample	211
Nanoplastics-mediated physiologic and genomic responses in pathogenic Escherichia coli O157:H7	206
Biocompatible exosome-modified fibrin gel accelerates the recovery of spinal cord injury by VGF-mediated oligodendrogenesis	206
Microneedle delivery system with rapid dissolution and sustained release of bleomycin for the treatment of hemangiomas	200
Correction: Bacterial outer membrane vesicle-cancer cell hybrid membrane-coated nanoparticles for sonodynamic therapy in the treatment of breast cancer bone metastasis	192
Correction: Conductive single-wall carbon nanotubes/extracellular matrix hybrid hydrogels promote the lineage-specific development of seeding cells for tissue repair through reconstructing an integrin	191
DNAzyme hydrogels specifically inhibit the NLRP3 pathway to prevent radiation-induced skin injury in mice	182
Harnessing protein sensing ability of electrochemical biosensors via a controlled peptide receptor–electrode interface	173
Self-disassembling diatomic nanocluster bomb unlock reciprocal synergistic multi-pathway cancer therapy	161
The current status of stimuli-responsive nanotechnologies on orthopedic titanium implant surfaces	158
αvβ3 integrin-specific exosomes engineered with cyclopeptide for targeted delivery of triptolide against malignant melanoma	156
Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cGAS-STING activation	154
Gold-nanosphere mitigates osteoporosis through regulating TMAO metabolism in a gut microbiota-dependent manner	153
Green synthesis of glyco-CuInS2 QDs with visible/NIR dual emission for 3D multicellular tumor spheroid and in vivo imaging	152
Engineering BiTE-inspired IPSC-exosomes to potentiate CAR-T cell therapy against lung cancer	151

Oral administration of Sophora Flavescens-derived exosomes-like nanovesicles carrying CX5461 ameliorates DSS-induced colitis in mice	148
Recent progress of non-linear topological structure polymers: synthesis, and gene delivery	148
Structural optimization of Sr/Zn-phosphate conversion coatings triggered by ions preloading on micro/nanostructured titanium surfaces for bacterial infection control and enhanced osteogenesis	147
MXene-based nanosheet for enhanced glioma therapy via photonic hyperthermia to boost the abscopal effect of radioimmunotherapy	146
A multifunctional ICAM1-directed MnO₂@ZIF8 nanoplatform with Tanshinone IIA synergistically reverses senescence and restores alveolar regeneration in septic lung injury	146
Multifunctional copper-based nanoparticles potentiate colorectal cancer immunotherapy via synergistic metabolic remodeling and cGAS-STING pathway activation	143
Inorganic nanoparticle-based treatment approaches for colorectal cancer: recent advancements and challenges	139
An exosomal strategy for targeting cancer-associated fibroblasts mediated tumors desmoplastic microenvironments	139
Gouqi-derived nanovesicles (GqDNVs) inhibited dexamethasone-induced muscle atrophy associating with AMPK/SIRT1/PGC1α signaling pathway	138
Macrophage membrane-camouflaged biomimetic nanoparticles for rheumatoid arthritis treatment via modulating macrophage polarization	136
Recent advances of metal-based nanoparticles in nucleic acid delivery for therapeutic applications	135
Intestinal nanoparticle delivery and cellular response: a review of the bidirectional nanoparticle-cell interplay in mucosa based on physiochemical properties	135
New anti-cancer explorations based on metal ions	134
Targeting and repolarizing M2-like tumor-associated macrophage-mediated MR imaging and tumor immunotherapy by biomimetic nanoparticles	129
Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks	122
An encounter between metal ions and natural products: natural products-coordinated metal ions for the diagnosis and treatment of tumors	119
A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression	117
Biomimetic β-lapachone and hemin nanoassembly for intracellular oxidation cascade amplified ferroptosis in hepatocellular carcinoma therapy	115
Exosomes: compositions, biogenesis, and mechanisms in diabetic wound healing	114
Co-delivery of axitinib and PD-L1 siRNA for the synergism of vascular normalization and immune checkpoint inhibition to boost anticancer immunity	114
Multifunctional nanoagonist enhances photodynamic therapy-driven in situ cancer vaccination by inhibiting tumor thrombosis	113
Piezoelectric heterojunction/polyetherketoneketone composite with enhanced sonodynamic efficacy and nanozyme activities for anti-infection and encouraging neurovascular ossification	113
Pathogen-microenvironment-responsive and antioxidant-buffered propiconazole nanofungicide for safe and effective fungal disease control	112
Maternal exposure to fullerenols impairs placental development in mice by inhibiting estriol synthesis and reducing ERα	112
A clinically feasible circulating tumor cell sorting system for monitoring the progression of advanced hepatocellular carcinoma	111
De novo strategy of organic semiconducting polymer brushes for NIR-II light-triggered carbon monoxide release to boost deep-tissue cancer phototheranostics	111
Targeting CAD with a tumor microenvironment-responsive nano-heterojunction for synergistic induction of cuproptosis and inhibition of colorectal cancer progression	111
Oxygen vacancy-engineered bimetallic nanozymes for disrupting electron transport chain and synergistic multi-enzyme activity to reverse oxaliplatin resistance in colorectal cancer	111
H2S-responsive CuSe nanoparticles convert into CuSSe in situ with band gap modulation for oxygen self-supply and enhanced colon cancer phototherapy	109
Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modula	108
High-throughput synthesis and optimization of ionizable lipids through A3 coupling for efficient mRNA delivery	107
Fusiform nanoparticle boosts efficient genetic transformation in Sclerotinia sclerotiorum	106
A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation	106
Curcumin-loaded copper/iron bimetallic nanoparticle-incorporated hydrogel scaffold: a sequential microenvironment reprogramming platform for accelerated chronic wound healing	106
Immune-modified exosome vaccine loaded with liver cancer epitope peptides induces potent and specific antitumor immunity	104
The nucleic acid reactions on the nanomaterials surface for biomedicine	104
MnO2 and roflumilast-loaded probiotic membrane vesicles mitigate experimental colitis by synergistically augmenting cAMP in macrophage	103
Exosomes from umbilical cord-derived mesenchymal stem cells combined with gelatin methacryloyl inhibit vein graft restenosis by enhancing endothelial functions	102
Mesoporous multimetallic PdPtBi nanozymes target redox imbalance and glutamine deprivation for immuno-chemodynamic therapy	101
Dual-function TA@CaCO3 nanomedicine targeting M2 macrophage lipid peroxidation sensitivity in rheumatoid arthritis therapy	100
Assembling Au8 clusters on surfaces of bifunctional nanoimmunomodulators for synergistically enhanced low dose radiotherapy of metastatic tumor	99
Design and mechanistic insights into ZMF59/CpG: a complementary adjuvant system boosting immunity and safety in herpes zoster vaccines	97
Design of a new electrochemical aptasensor based on screen printed carbon electrode modified with gold nanoparticles for the detection of fumonisin B1 in maize flour	96
Glutathione responsive iNOS inhibiting polymeric prodrug for targeted Inhibition of angiogenesis	96
Visualization of photothermal therapy by semiconducting polymer dots mediated photoacoustic detection in NIR II	94
Tumor-activated dual metabolic nanomodulator turns over tolerogenic tumor control and unleashes systemic immune responses	93
Immunomodulating melatonin-decorated silica nanoparticles suppress bacterial wilt (Ralstonia solanacearum) in tomato (Solanum lycopersicum L.) through fine-tuning of oxidative signaling and rhizospher	93
Nanotechnology for research and treatment of the intestine	92
An oxygen-generating nanoplatform remodels the immunosuppressive tumor microenvironment via synergistic lactate depletion and sonodynamic therapy	91
Cartilage targeting therapy with reactive oxygen species-responsive nanocarrier for osteoarthritis	91

3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair	91
Self-activated prodrug nanocomposites reprogramming lactic acid metabolism to initiate acidosis-endoplasmic reticulum stress cascade and potentiate immunogenic cell death for enhanced liver cancer the	90
Customizing cancer treatment at the nanoscale: a focus on anaplastic thyroid cancer therapy	89
Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome	88
Correction: SIRT5-modified human umbilical cord mesenchymal stem cells loaded with antioxidant polydopamine nanozyme enhance parpi resistance in ovarian cancer via fatty acid metabolism reprogramming	88
Harnessing smart nanomaterials to reprogram neutrophil plasticity in immune modulation	88
PDGFR-α shRNA-polyplex for uveal melanoma treatment via EMT mediated vasculogenic mimicry interfering	87
3D printed hydrogel scaffolds combining glutathione depletion-induced ferroptosis and photothermia-augmented chemodynamic therapy for efficiently inhibiting postoperative tumor recurrence	87
Microbial hydrogen “manufactory” for enhanced gas therapy and self-activated immunotherapy via reduced immune escape	87
Lipid liquid-crystalline nanoparticles as a suitable platform for accommodating sensitive membrane proteins: monitoring the activity of HMG-CoA reductase	86
CT-sensitized nanoprobe for effective early diagnosis and treatment of pulmonary fibrosis	85
Tumor-specific enhanced NIR-II photoacoustic imaging via photothermal and low-pH coactivated AuNR@PNIPAM-VAA nanogel	85
Molybdesum selenide-based platelet-rich plasma containing carboxymethyl chitosan/polyvinyl pyrrolidone composite antioxidant hydrogels dressing promotes the wound healing	85
PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer	85