Organic & Biomolecular Chemistry

Papers
(The TQCC of Organic & Biomolecular Chemistry is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)
ArticleCitations
Visible-Light-Induced C-S Bond Formation in the Synthesis of 2,4-Disubstituted Thiazoles through Cascade Difunctionalization of Acetophenone: A Greener Approach858791986
Synthesis of unsymmetric phosphorotrithioates by sequential coupling of 1,1-dichloro-N,N-diethylphosphanamine with thiols and sulfenyl chloride856241673
Water-enabling strategies for asymmetric catalysis154284082
Thioxanthone: a powerful photocatalyst for organic reactions105
Advances in deep eutectic solvents and water: applications in metal- and biocatalyzed processes, in the synthesis of APIs, and other biologically active compounds87
Recent advances in Rh(iii)/Ir(iii)-catalyzed C–H functionalization/annulation via carbene migratory insertion77
Recent advances in ring-opening of donor acceptor cyclopropanes using C-nucleophiles73
The chemistry and biology of fungal meroterpenoids (2009–2019)71
Metal-catalyzed C–S bond formation using sulfur surrogates65
Recent advances in using 4DPAIPN in photocatalytic transformations62
Tris(pentafluorophenyl)borane catalyzed C–C and C–heteroatom bond formation56
Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle52
Multicomponent reactions as a potent tool for the synthesis of benzodiazepines52
Recent advancements in the development of molecular organic photocatalysts50
Recent advances in aminative difunctionalization of alkenes50
Recent advances in transition metal-free annulation toward heterocycle diversity based on the C–N bond cleavage of enaminone platform48
Modern approaches towards the synthesis of geminal difluoroalkyl groups47
Silicon phthalocyanines: synthesis and resurgent applications46
Recent advances in the synthesis of α-amino ketones45
Metallaphotoredox catalysis with organic dyes43
Optical sensing of anions by macrocyclic and interlocked hosts42
Electrohalogenation of organic compounds41
Visible-light-induced silylation: an update41
Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles40
Recent advances in nickel-catalyzed C–C and C–N bond formation via HA and ADC reactions40
Recent advances in the synthesis and applications of β-keto sulfones: new prospects for the synthesis of β-keto thiosulfones40
Photoaffinity labelling strategies for mapping the small molecule–protein interactome39
Light-induced borylation: developments and mechanistic insights39
Recent advances in the Rh-catalyzed cascade arene C–H bond activation/annulation toward diverse heterocyclic compounds37
Recent progress on electrochemical synthesis involving carboxylic acids37
Nickel catalysts in Sonogashira coupling reactions36
Electrochemical synthesis of sulfonated benzothiophenes using 2-alkynylthioanisoles and sodium sulfinates36
Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules36
Construction of bridged polycycles through dearomatization strategies36
Recent progress in the synthesis of pyrrolo[2,1-a]isoquinolines35
Removal and modification of directing groups used in metal-catalyzed C–H functionalization: the magical step of conversion into ‘conventional’ functional groups34
Ruthenium(ii) complexes with N-heterocyclic carbene–phosphine ligands for the N-alkylation of amines with alcohols33
Asymmetric synthesis of organophosphorus compounds using H–P reagents derived from chiral alcohols33
Recent developments in enantio- and diastereoselective hydrogenation of N-heteroaromatic compounds33
Iminosugars as glycosyltransferase inhibitors32
Overview of coumarin-fused-coumarins: synthesis, photophysical properties and their applications32
Recent advances in the synthesis of indolizine and its derivatives by radical cyclization/cross-coupling32
Strategies for organelle targeting of fluorescent probes32
An update on the progress of cycloaddition reactions of 3-methyleneindolinones in the past decade: versatile approaches to spirooxindoles31
Forgotten and forbidden chemical reactions revitalised through continuous flow technology31
Advances in palladium-catalysed imidoylative cyclization of functionalized isocyanides for the construction of N-heterocycles31
Expeditious entry into carbocyclic and heterocyclic spirooxindoles31
α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update30
Recent advances in single-benzene-based fluorophores: physicochemical properties and applications30
Approaches for peptide and protein cyclisation30
Visible-light-mediated cascade cyanoalkylsulfonylation/cyclization of alkynoates leading to coumarins via SO2 insertion29
Reactions promoted by hypervalent iodine reagents and boron Lewis acids29
Copper-catalyzed Goldberg-type C–N coupling in deep eutectic solvents (DESs) and water under aerobic conditions29
Metal–ligand cooperative approaches in homogeneous catalysis using transition metal complex catalysts of redox noninnocent ligands29
Synthesis of 2H-chromenes: recent advances and perspectives29
Beyond osmium: progress in 1,2-amino oxygenation of alkenes, 1,3-dienes, alkynes, and allenes29
Electrochemical regioselective C–H selenylation of 2H-indazole derivatives29
Reframing primary alkyl amines as aliphatic building blocks28
Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles28
Rh(iii)-catalyzed C–H annulation of sulfoxonium ylides with iodonium ylides towards isocoumarins28
Eosin: a versatile organic dye whose synthetic uses keep expanding28
Indicator displacement assays: from concept to recent developments27
Halogen bond-induced electrophilic aromatic halogenations27
Recent advances in the synthesis of pyrido[1,2-a]indoles27
Ionic liquids: “normal” solvents or nanostructured fluids?26
Peroxide-mediated synthesis of benzimidazo[2,1-a]isoquinoline-6(5H)-ones via cascade methylation/ethylation and intramolecular cyclization26
Green solvents for the formation of amide linkages26
Red-shifted tetra-ortho-halo-azobenzenes for photo-regulated transmembrane anion transport25
Facile synthesis of carbamoylated benzimidazo[2,1-a]isoquinolin-6(5H)-ones via radical cascade cyclization under metal-free conditions25
Total synthesis of apratoxin A and B using Matteson's homologation approach25
Recent progress of direct thiocyanation reactions25
Recent developments in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as CC–N donors25
CpxM(iii)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes25
A comprehensive insight into aldehyde deformylation: mechanistic implications from biology and chemistry25
Electrosynthetic C–F bond cleavage25
Molecular cages for biological applications24
Catalyst-free and additive-free reactions enabling C–C bond formation: a journey towards a sustainable future24
Asparaginyl endopeptidases: enzymology, applications and limitations24
Controlling selectivity in N-heterocycle directed borylation of indoles24
Recent advances in the applications of pyrazolone derivatives in enantioselective synthesis24
Phosphorus containing porous organic polymers: synthetic techniques and applications in organic synthesis and catalysis24
DABSO as a SO2 gas surrogate in the synthesis of organic structures24
Synthesis and reactivity of alkynyl boron compounds23
Stereodivergent Pd/Cu catalysis: asymmetric alkylation of racemic symmetrical 1,3-diphenyl allyl acetates23
Copper-catalyzed P–H insertion reactions of sulfoxonium ylides23
Current developments in the synthesis of 4-chromanone-derived compounds23
Recent approaches to the synthesis of tetrahydrocarbazoles23
Recent advances in reactions using diacyl peroxides as sources of O- and C-functional groups23
Copper-catalyzed radical cascade cyclization for synthesis of CF3-containing tetracyclic benzimidazo[2,1-a]iso-quinolin-6(5H)-ones23
Hancockiamides: phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway23
Applications of catalysis in hydroboration of imines, nitriles, and carbodiimides23
An expeditious and highly efficient synthesis of substituted pyrroles using a low melting deep eutectic mixture23
Updates on hypervalent-iodine reagents: metal-free functionalisation of alkenes, alkynes and heterocycles23
Exploration of Kobayashi's aryne precursor: a potent reactive platform for the synthesis of polycyclic aromatic hydrocarbons23
Synthesis and derivatization of hetera-buckybowls22
Nickel catalyzed sustainable synthesis of benzazoles and purines via acceptorless dehydrogenative coupling and borrowing hydrogen approach22
Catalytic asymmetric synthesis of 5-membered alicyclic α-quaternary β-amino acids via [3 + 2]-photocycloaddition of α-substituted acrylates22
Visible-light-promoted selective O-alkylation of 2-pyridones with α-aryldiazoacetates22
Recent highlights of biosynthetic studies on marine natural products21
Dinuclear zinc-catalyzed enantioselective formal [3 + 2] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with low reactivity aurone derivatives21
Transition-metal-catalyzed ortho-selective C–H functionalization reactions of free phenols21
Construction of an IMiD-based azide library as a kit for PROTAC research21
Metal-catalyzed reactions of organic nitriles and boronic acids to access diverse functionality21
A reference scale of cucurbit[7]uril binding affinities21
Recent progress in the nitration of arenes and alkenes20
Iodine–TBHP mediated efficient synthesis of α-ketoamides from vinyl azides and amines under mild conditions20
Total synthesis of the pseudoindoxyl class of natural products20
Sulfur(vi) fluorides as tools in biomolecular and medicinal chemistry20
Synthesis of polychloromethylated and halogenated spiro[5,5]trienones via dearomative spirocyclization of biaryl ynones20
An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction20
Recent advances in the transition metal-free oxidative dehydrogenative aromatization of cyclohexanones20
Cu(ii)-catalyzed domino construction of spironaphthalenones by dearomatization of β-naphthols and using N,N-dimethylaminoethanol as a C1 synthon20
Artificial enzymes bringing together computational design and directed evolution20
Predicting the catalytic activity of azolium-based halogen bond donors: an experimentally-verified theoretical study20
Recent advances on triptycene derivatives in supramolecular and materials chemistry19
A BODIPY-O-glycoside based near-infrared fluorescent sensor for serum albumin19
Gold-catalyzed hydroarylation reactions: a comprehensive overview19
Synthesis of functionalized indoles via cascade benzannulation strategies: a decade's overview19
C(sp2)–H functionalization in non-aromatic azomethine-based heterocycles19
NIS-promoted three-component reaction of 3-oxo-3-arylpropanenitriles with arylsulfonyl hydrazides19
Carbon dioxide based methodologies for the synthesis of fine chemicals19
Recent advances in palladium-catalyzed C(sp3)/C(sp2)–H bond functionalizations: access to C-branched glycosides19
Enantioselective catalytic Povarov reactions19
Application of DMSO as a methylthiolating reagent in organic synthesis19
The transition-metal-catalyzed stereoselective ring-expansion of vinylaziridines and vinyloxiranes19
Recent advances in pyrazole synthesis employing diazo compounds and synthetic analogues19
Recent progress towards the transition-metal-catalyzed Nazarov cyclization of alkynes via metal carbenes19
NaI/KI/NH4I and TBHP as powerful oxidation systems: use in the formation of various chemical bonds19
Stereoselective synthesis of fused-, spiro- and bridged heterocycles via cyclization of isoquinolinium salts: a recent update19
Recent advances in the synthesis of pyrrolo[1,2-a]indoles and their derivatives19
Radical bromination-induced ipso cyclization–ortho cyclization sequence of N-hydroxylethyl-N-arylpropiolamides18
Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules18
The role of intermolecular forces in ionic reactions: the solvent effect, ion-pairing, aggregates and structured environment18
Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-2218
Recent progress in organophotoredox reaction18
Visible light-promoted photocatalyst-free activation of persulfates: a promising strategy for C–H functionalization reactions18
A Zn(ii)-functionalized COF as a recyclable catalyst for the sustainable synthesis of cyclic carbonates and cyclic carbamates from atmospheric CO218
Conjugated ynones in catalytic enantioselective reactions18
Chemical probes targeting the kinase CK2: a journey outside the catalytic box18
Azulene as an ingredient for visible-light- and stimuli-responsive photoswitches18
Electrocatalytic hydrogenation of benzoic acids in a proton-exchange membrane reactor18
Selected applications of Meldrum's acid – a tutorial18
Chiral cyclometalated iridium complexes for asymmetric reduction reactions18
Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen–Friedenreich conjugate17
A review on the assembly of multi-substituted pyridines via Co-catalyzed [2 + 2 + 2] cycloaddition with nitriles17
Crown ether–pillararene hybrid macrocyclic systems17
Arylcyclopropane yet in its infancy: the challenges and recent advances in its functionalization17
Hydroxyl-group-activated azomethine ylides in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions and beyond17
Cascade cyclization for the synthesis of indolo[2,1-α]isoquinoline derivatives via visible-light-induced halogen-atom-transfer (XAT) and hydrogen-atom-transfer (HAT)17
C-5 selective chlorination of 8-aminoquinoline amides using dichloromethane17
Iodine(iii) reagents for oxidative aromatic halogenation17
Ring closing metathesis for the construction of carbazole and indole-fused natural products17
Modern methods for the synthesis of perfluoroalkylated aromatics17
B(C6F5)3-catalyzed O–H insertion reactions of diazoalkanes with phosphinic acids16
Visible light-induced selenylative spirocyclization of biaryl ynones toward the formation of selenated spiro[5.5]trienones16
Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards novel sp3-rich chemical space16
Supramolecular brush polymers prepared from 1,3,4-oxadiazole and cyanobutoxy functionalised pillar[5]arene for detecting Cu2+16
Generation and trapping of electron-deficient 1,2-cyclohexadienes. Unexpected hetero-Diels–Alder reactivity16
Direct functionalization of quinoxalin-2(1H)-one with alkanes: C(sp2)–H/C(sp3)–H cross coupling in transition metal-free mode16
Recent advances in C–F bond activation of trifluoromethylated carbonyl compounds and derivatives16
Continuous-flow electrosynthesis of selenium-substituted iminoisobenzofuran via oxidative cyclization of olefinic amides and diselenides16
N-Triflylphosphoramides: highly acidic catalysts for asymmetric transformations16
Synthesis of indolo[2,1-α]isoquinoline derivatives via metal-free radical cascade cyclization16
Silicon compounds as stoichiometric coupling reagents for direct amidation16
Recent advances in transition-metal-catalyzed directed C–H alkenylation with maleimides16
Electro-organic synthesis: an environmentally benign alternative for heterocycle synthesis16
Time-economical synthesis of selenofunctionalized heterocycles via I2O5-mediated selenylative heterocyclization16
Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions16
Glycosyl disulfides: importance, synthesis and application to chemical and biological systems16
Recent reports on the synthesis of γ-butenolide, γ-alkylidenebutenolide frameworks, and related natural products16
Deoxygenation reactions in organic synthesis catalyzed by dioxomolybdenum(vi) complexes16
Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones16
A photocatalyst-free visible-light-mediated solvent-switchable route to stilbenes/vinyl sulfones from β-nitrostyrenes and arylazo sulfones16
Recent advances in rhodium-catalyzed C(sp2)–H (hetero)arylation16
Biotin-decorated NIR-absorbing nanosheets for targeted photodynamic cancer therapy16
Chemoselective synthesis of fully substituted pyrroles via a one-pot four-component isocyanide-based reaction16
Recent advances in the carbon–phosphorus (C–P) bond formation from unsaturated compounds by s- and p-block metals16
Dissipative control of the fluorescence of a 1,3-dipyrenyl calix[4]arene in the cone conformation15
Advances of α-activated cyclic isothiocyanate for the enantioselective construction of spirocycles15
Recent strategies used in the synthesis of saturated four-membered heterocycles15
Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions15
Biocatalytic approaches for enantio and diastereoselective synthesis of chiral β-nitroalcohols15
Synthesis of macrocyclic and medium-sized ring thiolactones via the ring expansion of lactams15
Metal-free polychloromethyl radical-initiated cyclization of unactivated N-allylindoles towards pyrrolo[1,2-a]indoles15
Phosphorylation of arenes, heteroarenes, alkenes, carbonyls and imines by dehydrogenative cross-coupling of P(O)–H and P(R)–H15
Photoinduced efficient synthesis of cyanoalkylsulfonylated oxindoles via sulfur dioxide insertion15
Glucose conjugated aza-BODIPY for enhanced photodynamic cancer therapy15
Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKIα activity and circadian rhythms15
Live-cell imaging of the nucleolus and mapping mitochondrial viscosity with a dual function fluorescent probe15
Binaphthyl–prolinol chiral ligands: design and their application in enantioselective arylation of aromatic aldehydes15
Sulfur-controlled and rhodium-catalyzed formal (3 + 3) transannulation of thioacyl carbenes with alk-2-enals and mechanistic insights15
A sustainable C–H functionalization of indoles, pyrroles and furans under a blue LED with iodonium ylides15
Recent advances in the copper-catalyzed aerobic Csp3–H oxidation strategy15
(4 + 2) cyclization of aza-o-quinone methides with azlactones: construction of biologically important dihydroquinolinone frameworks15
Design, synthesis and biological evaluation of a halogenated phenazine-erythromycin conjugate prodrug for antibacterial applications15
Metal-free three-component cyanoalkylation of quinoxalin-2(1H)-ones with vinylarenes and azobis(alkylcarbonitrile)s15
Tricyclic 2-benzazepines obtained via an unexpected cyclization involving nitrilium ylides14
Catalytic and highly regenerable aminic organoselenium antioxidants with cytoprotective effects14
Nitroarenes and nitroalkenes as potential amino sources for the synthesis of N-heterocycles14
A novel near-infrared fluorescent probe based on isophorone for the bioassay of endogenous cysteine14
Copper-catalyzed [3 + 2]-cycloaddition of α-halonitroalkenes with azomethine ylides: facile synthesis of multisubstituted pyrrolidines and pyrroles14
N-Alkenylation of hydroxamic acid derivatives with ethynyl benziodoxolone to synthesize cis-enamides through vinyl benziodoxolones14
Enantioselective N-heterocyclic carbene-catalysed intermolecular crossed benzoin condensations: improved catalyst design and the role of in situ racemisation14
Mannich-type allylic C–H functionalization of enol silyl ethers under photoredox–thiol hybrid catalysis14
Copper-catalyzed ortho-selective direct sulfenylation of N-aryl-7-azaindoles with disulfides14
Selective photoredox direct arylations of aryl bromides in water in a microfluidic reactor14
Synthetic enzyme-catalyzed multicomponent reaction for Isoxazol-5(4H)-one Syntheses, their properties and biological application; why should one study mechanisms?14
Visible-light-promoted trifluoromethylselenolation of ortho-hydroxyarylenaminones14
Chemoselective electrochemical reduction of nitroarenes with gaseous ammonia14
Recent advances in the direct O-arylation of carbohydrates14
The construction of benzimidazo[2,1-a]isoquinolin-6(5H)-ones from N-methacryloyl-2-phenylbenzoimidazoles through radical strategies14
Diversification of α-ketoamides via transamidation reactions with alkyl and benzyl amines at room temperature14
Asymmetric oxidative Mannich reactions promoted by photocatalysis and electrochemistry14
Xanthene-based functional dyes: towards new molecules operating in the near-infrared region14
Visible-light promoted oxidative cyclization of cinnamic acid derivatives using xanthone as the photocatalyst14
Oxidative cross-coupling of thiols for S–X (X = S, N, O, P, and C) bond formation: mechanistic aspects14
Metal-free regioselective C–H amination for the synthesis of pyrazole-containing 2H-indazoles14
Constructing firefly luciferin bioluminescence probes for in vivo imaging14
Organocatalytic enantioselective aza-Friedel–Crafts reaction between benzothiazolimines and 2-naphthols for the preparation of chiral 2′-aminobenzothiazolomethyl naphthols14
I2-mediated coupling of quinazolinone enamines with 2-aminopyridines: a new strategy to access spiroquinazolinones14
Unprecedented access to functionalized pyrrolo[2,1-a]isoquinolines from the domino reaction of isoquinolinium ylides and electrophilic benzannulated heterocycles14
Possible competitive modes of decarboxylation in the annulation reactions of ortho-substituted anilines and arylglyoxylates14
Recent advances in the tandem copper-catalyzed Ullmann–GoldbergN-arylation–cyclization strategies13
Copper(ii)-catalyzed oxidative ipso-annulation of N-arylpropiolamides and biaryl ynones with 1,3-diketones: construction of diketoalkyl spiro-trienones13
Synthesis of 3-halogenated 2,3′-biindoles by a copper-mediated 2,3-difunctionalization of indoles13
Regioselective C–H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions13
A high-yielding solid-phase total synthesis of daptomycin using a Fmoc SPPS stable kynurenine synthon13
Catalytic asymmetric umpolung reactions of imines via 2-azaallyl anion intermediates13
Diaryliodonium(iii) salts in one-pot double functionalization of C–IIIIandorthoC–H bonds13
Visible-light-promoted photocatalyst-free alkylation and acylation of benzothiazoles13
Electrocatalytic three-component synthesis of 4-halopyrazoles with sodium halide as the halogen source13
N-Heterocyclic carbene (NHC)-catalyzed intramolecular benzoin condensation–oxidation13
Highly selective C3–H iodination of pyrrolo[1,2-a]quinoxalines13
Enantioselective [3 + 2] annulation of 4-isothiocyanato pyrazolones and alkynyl ketones under organocatalysis13
Application of combined cyanide sources in cyanation reactions13
Nickel-promoted oxidative domino Csp3–H/N–H bond double-isocyanide insertion reaction to construct pyrrolin-2-ones13
Rongalite-induced transition-metal and hydride-free reductive aldol reaction: a rapid access to 3,3′-disubstituted oxindoles and its mechanistic studies13
Dibismuthanes in catalysis: from synthesis and characterization to redox behavior towards oxidative cleavage of 1,2-diols13
Total synthesis of cynaropicrin13
Computational evidence of glycosyl cations13
Bismuth(iii) triflate as a novel and efficient activator for glycosyl halides13
Recent progress in the radical α-C(sp3)–H functionalization of ketones13
A colorimetric sensor array for the classification of biologically relevant tri-, di- and mono-phosphates13
Directmetasubstitution of calix[4]arenes13
An enantioselective aza-Friedel–Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines13
An easy and practical approach to access multifunctional cylcopentadiene- and cyclopentene-spirooxindoles via [3 + 2] annulation13
Contemporary advancements in the semi-synthesis of bioactive terpenoids and steroids13
Recent advances in the application of Langlois’ reagent in olefin difunctionalization13
Construction of aziridine, azetidine, indole and quinoline-like heterocycles via Pd-mediated C–H activation/annulation strategies13
Electrochemical sulfonylation of enamides with sodium sulfinates to access β-amidovinyl sulfones13
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