Organic & Biomolecular Chemistry

Article	Citations
Thioxanthone: a powerful photocatalyst for organic reactions	134
Advances in deep eutectic solvents and water: applications in metal- and biocatalyzed processes, in the synthesis of APIs, and other biologically active compounds	97
Recent advances in ring-opening of donor acceptor cyclopropanes using C-nucleophiles	90
The chemistry and biology of fungal meroterpenoids (2009–2019)	87
Recent advances in Rh(iii)/Ir(iii)-catalyzed C–H functionalization/annulation via carbene migratory insertion	85
Recent advances in using 4DPAIPN in photocatalytic transformations	78
Metal-catalyzed C–S bond formation using sulfur surrogates	75
Tris(pentafluorophenyl)borane catalyzed C–C and C–heteroatom bond formation	68
Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle	64
Recent advancements in the development of molecular organic photocatalysts	62
Recent advances in transition metal-free annulation toward heterocycle diversity based on the C–N bond cleavage of enaminone platform	62
Recent advances in the synthesis of α-amino ketones	61
Silicon phthalocyanines: synthesis and resurgent applications	59
Recent advances in aminative difunctionalization of alkenes	58
Multicomponent reactions as a potent tool for the synthesis of benzodiazepines	56
Recent advances in the synthesis and applications of β-keto sulfones: new prospects for the synthesis of β-keto thiosulfones	53
Recent advances in nickel-catalyzed C–C and C–N bond formation via HA and ADC reactions	52
Modern approaches towards the synthesis of geminal difluoroalkyl groups	52
Construction of bridged polycycles through dearomatization strategies	51
Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles	48
Visible-light-induced silylation: an update	48
Photoaffinity labelling strategies for mapping the small molecule–protein interactome	48
Recent progress in the synthesis of pyrrolo[2,1-a]isoquinolines	48
Optical sensing of anions by macrocyclic and interlocked hosts	47
Electrohalogenation of organic compounds	47

Metallaphotoredox catalysis with organic dyes	47
Recent progress on electrochemical synthesis involving carboxylic acids	46
Nickel catalysts in Sonogashira coupling reactions	46
Light-induced borylation: developments and mechanistic insights	46
Recent developments in enantio- and diastereoselective hydrogenation of N-heteroaromatic compounds	45
Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules	45
Recent advances in single-benzene-based fluorophores: physicochemical properties and applications	43
Approaches for peptide and protein cyclisation	43
Strategies for organelle targeting of fluorescent probes	43
Recent advances in the synthesis of indolizine and its derivatives by radical cyclization/cross-coupling	42
Expeditious entry into carbocyclic and heterocyclic spirooxindoles	42
Recent advances in the Rh-catalyzed cascade arene C–H bond activation/annulation toward diverse heterocyclic compounds	42
Overview of coumarin-fused-coumarins: synthesis, photophysical properties and their applications	41
Electrochemical synthesis of sulfonated benzothiophenes using 2-alkynylthioanisoles and sodium sulfinates	40
Ruthenium(ii) complexes with N-heterocyclic carbene–phosphine ligands for the N-alkylation of amines with alcohols	40
α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update	39
Metal–ligand cooperative approaches in homogeneous catalysis using transition metal complex catalysts of redox noninnocent ligands	38
Reactions promoted by hypervalent iodine reagents and boron Lewis acids	37
An update on the progress of cycloaddition reactions of 3-methyleneindolinones in the past decade: versatile approaches to spirooxindoles	36
Removal and modification of directing groups used in metal-catalyzed C–H functionalization: the magical step of conversion into ‘conventional’ functional groups	36
Reframing primary alkyl amines as aliphatic building blocks	36
Forgotten and forbidden chemical reactions revitalised through continuous flow technology	36
Asymmetric synthesis of organophosphorus compounds using H–P reagents derived from chiral alcohols	36
Copper-catalyzed Goldberg-type C–N coupling in deep eutectic solvents (DESs) and water under aerobic conditions	35
Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles	35
Halogen bond-induced electrophilic aromatic halogenations	35
Recent advances in the synthesis of pyrrolo[1,2-a]indoles and their derivatives	35
Eosin: a versatile organic dye whose synthetic uses keep expanding	34
Iminosugars as glycosyltransferase inhibitors	34
Advances in palladium-catalysed imidoylative cyclization of functionalized isocyanides for the construction of N-heterocycles	34
Molecular cages for biological applications	34
Electrochemical regioselective C–H selenylation of 2H-indazole derivatives	34
Indicator displacement assays: from concept to recent developments	34
Beyond osmium: progress in 1,2-amino oxygenation of alkenes, 1,3-dienes, alkynes, and allenes	34
Recent developments in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as CC–N donors	34
Recent progress of direct thiocyanation reactions	33
Synthesis of 2H-chromenes: recent advances and perspectives	33
DABSO as a SO2 gas surrogate in the synthesis of organic structures	33
Electrosynthetic C–F bond cleavage	33
Recent advances in the applications of pyrazolone derivatives in enantioselective synthesis	32
Red-shifted tetra-ortho-halo-azobenzenes for photo-regulated transmembrane anion transport	32
Recent advances in the synthesis of pyrido[1,2-a]indoles	31
Visible-light-mediated cascade cyanoalkylsulfonylation/cyclization of alkynoates leading to coumarins via SO2 insertion	31
Ionic liquids: “normal” solvents or nanostructured fluids?	31
Current developments in the synthesis of 4-chromanone-derived compounds	31
Total synthesis of the pseudoindoxyl class of natural products	31
Rh(iii)-catalyzed C–H annulation of sulfoxonium ylides with iodonium ylides towards isocoumarins	31
Total synthesis of apratoxin A and B using Matteson's homologation approach	30
Recent advances in pyrazole synthesis employing diazo compounds and synthetic analogues	30
Sulfur(vi) fluorides as tools in biomolecular and medicinal chemistry	30

Applications of catalysis in hydroboration of imines, nitriles, and carbodiimides	30
Enantioselective catalytic Povarov reactions	29
Copper-catalyzed P–H insertion reactions of sulfoxonium ylides	29
Catalyst-free and additive-free reactions enabling C–C bond formation: a journey towards a sustainable future	29
A comprehensive insight into aldehyde deformylation: mechanistic implications from biology and chemistry	29
Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards novel sp3-rich chemical space	29
Synthesis and derivatization of hetera-buckybowls	29
CpxM(iii)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes	28
Green solvents for the formation of amide linkages	28
Peroxide-mediated synthesis of benzimidazo[2,1-a]isoquinoline-6(5H)-ones via cascade methylation/ethylation and intramolecular cyclization	28
Hancockiamides: phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway	28
Updates on hypervalent-iodine reagents: metal-free functionalisation of alkenes, alkynes and heterocycles	28
Facile synthesis of carbamoylated benzimidazo[2,1-a]isoquinolin-6(5H)-ones via radical cascade cyclization under metal-free conditions	28
Recent progress in the nitration of arenes and alkenes	28
Iodine–TBHP mediated efficient synthesis of α-ketoamides from vinyl azides and amines under mild conditions	28
A reference scale of cucurbit[7]uril binding affinities	28
Visible-light-promoted selective O-alkylation of 2-pyridones with α-aryldiazoacetates	28
Nickel catalyzed sustainable synthesis of benzazoles and purines via acceptorless dehydrogenative coupling and borrowing hydrogen approach	28
Synthesis and reactivity of alkynyl boron compounds	28
Recent advances in the synthesis of 2,3-fused quinazolinones	27
Phosphorus containing porous organic polymers: synthetic techniques and applications in organic synthesis and catalysis	27
Recent advances in reactions using diacyl peroxides as sources of O- and C-functional groups	27
Controlling selectivity in N-heterocycle directed borylation of indoles	27
Synthesis, reactions and application of chalcones: a systematic review	27
An expeditious and highly efficient synthesis of substituted pyrroles using a low melting deep eutectic mixture	27
Recent approaches to the synthesis of tetrahydrocarbazoles	27
Exploration of Kobayashi's aryne precursor: a potent reactive platform for the synthesis of polycyclic aromatic hydrocarbons	26
Copper-catalyzed radical cascade cyclization for synthesis of CF3-containing tetracyclic benzimidazo[2,1-a]iso-quinolin-6(5H)-ones	26
Recent advances on triptycene derivatives in supramolecular and materials chemistry	26
Asparaginyl endopeptidases: enzymology, applications and limitations	26
Recent advances in the transition metal-free oxidative dehydrogenative aromatization of cyclohexanones	26
An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction	26
Synthesis of polychloromethylated and halogenated spiro[5,5]trienones via dearomative spirocyclization of biaryl ynones	25
Recent progress in organophotoredox reaction	25
Stereodivergent Pd/Cu catalysis: asymmetric alkylation of racemic symmetrical 1,3-diphenyl allyl acetates	25
Azulene as an ingredient for visible-light- and stimuli-responsive photoswitches	25
NaI/KI/NH4I and TBHP as powerful oxidation systems: use in the formation of various chemical bonds	25
Stereoselective synthesis of fused-, spiro- and bridged heterocycles via cyclization of isoquinolinium salts: a recent update	25
Predicting the catalytic activity of azolium-based halogen bond donors: an experimentally-verified theoretical study	25
N-Triflylphosphoramides: highly acidic catalysts for asymmetric transformations	24
Recent highlights of biosynthetic studies on marine natural products	24
Chemical probes targeting the kinase CK2: a journey outside the catalytic box	24
Iodine(iii) reagents for oxidative aromatic halogenation	24
A Zn(ii)-functionalized COF as a recyclable catalyst for the sustainable synthesis of cyclic carbonates and cyclic carbamates from atmospheric CO2	24
Synthesis of functionalized indoles via cascade benzannulation strategies: a decade's overview	24
Visible-light-induced cascade reaction: a sustainable approach towards molecular complexity	24
Application of DMSO as a methylthiolating reagent in organic synthesis	24
Carbon dioxide based methodologies for the synthesis of fine chemicals	23
Selected applications of Meldrum's acid – a tutorial	23
Gold-catalyzed hydroarylation reactions: a comprehensive overview	23
Dinuclear zinc-catalyzed enantioselective formal [3 + 2] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with low reactivity aurone derivatives	23
Metal-catalyzed reactions of organic nitriles and boronic acids to access diverse functionality	23
Recent advances in transition-metal-catalyzed directed C–H alkenylation with maleimides	23
Cu(ii)-catalyzed domino construction of spironaphthalenones by dearomatization of β-naphthols and using N,N-dimethylaminoethanol as a C1 synthon	23
Phosphorylation of arenes, heteroarenes, alkenes, carbonyls and imines by dehydrogenative cross-coupling of P(O)–H and P(R)–H	23
A review on the assembly of multi-substituted pyridines via Co-catalyzed [2 + 2 + 2] cycloaddition with nitriles	23
Recent reports on the synthesis of γ-butenolide, γ-alkylidenebutenolide frameworks, and related natural products	23
A BODIPY-O-glycoside based near-infrared fluorescent sensor for serum albumin	23
Conjugated ynones in catalytic enantioselective reactions	23
Cascade cyclization for the synthesis of indolo[2,1-α]isoquinoline derivatives via visible-light-induced halogen-atom-transfer (XAT) and hydrogen-atom-transfer (HAT)	23
Catalytic asymmetric synthesis of 5-membered alicyclic α-quaternary β-amino acids via [3 + 2]-photocycloaddition of α-substituted acrylates	23
Construction of an IMiD-based azide library as a kit for PROTAC research	22
Time-economical synthesis of selenofunctionalized heterocycles via I2O5-mediated selenylative heterocyclization	22
The transition-metal-catalyzed stereoselective ring-expansion of vinylaziridines and vinyloxiranes	22
Transition-metal-catalyzed ortho-selective C–H functionalization reactions of free phenols	22
Recent advances in palladium-catalyzed C(sp3)/C(sp2)–H bond functionalizations: access to C-branched glycosides	22
Directmetasubstitution of calix[4]arenes	22
Diaryliodonium(iii) salts in one-pot double functionalization of C–IIIIandorthoC–H bonds	22
Visible light-induced selenylative spirocyclization of biaryl ynones toward the formation of selenated spiro[5.5]trienones	22
The role of intermolecular forces in ionic reactions: the solvent effect, ion-pairing, aggregates and structured environment	22
Hydroxyl-group-activated azomethine ylides in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions and beyond	22
C(sp2)–H functionalization in non-aromatic azomethine-based heterocycles	22
Visible light-promoted photocatalyst-free activation of persulfates: a promising strategy for C–H functionalization reactions	22
Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones	22
Ring closing metathesis for the construction of carbazole and indole-fused natural products	21
Artificial enzymes bringing together computational design and directed evolution	21
Electrocatalytic hydrogenation of benzoic acids in a proton-exchange membrane reactor	21
Recent advances in the accessibility, synthetic utility, and biological applications of aziridines	21
Modern methods for the synthesis of perfluoroalkylated aromatics	21
Electro-organic synthesis: an environmentally benign alternative for heterocycle synthesis	21

Continuous-flow electrosynthesis of selenium-substituted iminoisobenzofuran via oxidative cyclization of olefinic amides and diselenides	21
Chemoselective electrochemical reduction of nitroarenes with gaseous ammonia	20
Generation and trapping of electron-deficient 1,2-cyclohexadienes. Unexpected hetero-Diels–Alder reactivity	20
Iodonium ylides: an emerging and alternative carbene precursor for C–H functionalizations	20
Crown ether–pillararene hybrid macrocyclic systems	20
Recent advances in rhodium-catalyzed C(sp2)–H (hetero)arylation	20
A sustainable photochemical aerobic sulfide oxidation: access to sulforaphane and modafinil	20
Direct functionalization of quinoxalin-2(1H)-one with alkanes: C(sp2)–H/C(sp3)–H cross coupling in transition metal-free mode	20
Recent advances in the application of Langlois’ reagent in olefin difunctionalization	20
Recent progress towards the transition-metal-catalyzed Nazarov cyclization of alkynes via metal carbenes	20
Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-22	20
Biotin-decorated NIR-absorbing nanosheets for targeted photodynamic cancer therapy	20
Glucose conjugated aza-BODIPY for enhanced photodynamic cancer therapy	20
Application of combined cyanide sources in cyanation reactions	19
Diversification of α-ketoamides via transamidation reactions with alkyl and benzyl amines at room temperature	19
Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions	19
Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis	19
Oxidative cross-coupling of thiols for S–X (X = S, N, O, P, and C) bond formation: mechanistic aspects	19
N-Alkenylation of hydroxamic acid derivatives with ethynyl benziodoxolone to synthesize cis-enamides through vinyl benziodoxolones	19
C-5 selective chlorination of 8-aminoquinoline amides using dichloromethane	19
Recent advances in C–H functionalization of 2H-indazoles	19
An update on chiral phosphoric acid organocatalyzed stereoselective reactions	19
Silicon compounds as stoichiometric coupling reagents for direct amidation	19
Constructing firefly luciferin bioluminescence probes for in vivo imaging	19
Antitumor activity of tridentate pincer and related metal complexes	19
Unprecedented access to functionalized pyrrolo[2,1-a]isoquinolines from the domino reaction of isoquinolinium ylides and electrophilic benzannulated heterocycles	19
NIS-promoted three-component reaction of 3-oxo-3-arylpropanenitriles with arylsulfonyl hydrazides	19
C–H functionalization of pyridines	19
Nitroarenes and nitroalkenes as potential amino sources for the synthesis of N-heterocycles	19
Synthesis of macrocyclic and medium-sized ring thiolactones via the ring expansion of lactams	18
Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen–Friedenreich conjugate	18
Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules	18
TsCl-promoted thiolation of quinoline N-oxides with thiophenols	18
Copper-catalyzed [3 + 2]-cycloaddition of α-halonitroalkenes with azomethine ylides: facile synthesis of multisubstituted pyrrolidines and pyrroles	18
Chemoselective synthesis of fully substituted pyrroles via a one-pot four-component isocyanide-based reaction	18
Recent strategies used in the synthesis of saturated four-membered heterocycles	18
A photocatalyst-free visible-light-mediated solvent-switchable route to stilbenes/vinyl sulfones from β-nitrostyrenes and arylazo sulfones	18
Radical bromination-induced ipso cyclization–ortho cyclization sequence of N-hydroxylethyl-N-arylpropiolamides	18
Synthesis of 2-trifluoromethyl thiazoles via [3 + 2] cycloaddition of pyridinium 1,4-zwitterionic thiolates with CF3CN	18
Convenient semihydrogenation of azoarenes to hydrazoarenes using H2	18
Metal-free three-component cyanoalkylation of quinoxalin-2(1H)-ones with vinylarenes and azobis(alkylcarbonitrile)s	18
Sulfur-controlled and rhodium-catalyzed formal (3 + 3) transannulation of thioacyl carbenes with alk-2-enals and mechanistic insights	18
Chiral cyclometalated iridium complexes for asymmetric reduction reactions	18
Progressive study on ruthenium catalysis for de(hydrogenative) alkylation and alkenylation using alcohols as a sustainable source	18
Thia-Michael addition: the route to promising opportunities for fast and cysteine-specific modification	18
Distiboranes based on ortho-phenylene backbones as bidentate Lewis acids for fluoride anion chelation	18
Live-cell imaging of the nucleolus and mapping mitochondrial viscosity with a dual function fluorescent probe	18
Chiroptical sensing of amino acids, amines, amino alcohols, alcohols and terpenes with π-extended acyclic cucurbiturils	18
Visible-light-promoted trifluoromethylselenolation of ortho-hydroxyarylenaminones	18
An enantioselective aza-Friedel–Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines	18
Recent advances in C–F bond activation of trifluoromethylated carbonyl compounds and derivatives	18
Radical relay cyclization/C–C bond formation of allyloxy-tethered aryl iodides with quinoxalin-2(1H)-ones via polysulfide anion photocatalysis	18
Glycosyl disulfides: importance, synthesis and application to chemical and biological systems	18
Arylcyclopropane yet in its infancy: the challenges and recent advances in its functionalization	18
Recent advances in cascade reactions and their mechanistic insights: a concise strategy to synthesize complex natural products and organic scaffolds	17
Biocatalytic approaches for enantio and diastereoselective synthesis of chiral β-nitroalcohols	17
Scalable 18F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [18F]olaparib	17
Generalizable synthesis of bioresponsive near-infrared fluorescent probes: sulfonated heptamethine cyanine prototype for imaging cell hypoxia	17
Recent advances in the direct O-arylation of carbohydrates	17
Electrochemical monofluoroalkylation cyclization ofN-arylacrylamides to construct monofluorinated 2-oxindoles	17
Recent advances in C/N-alkylation with alcohols through hydride transfer strategies	17
Visible-light-promoted photocatalyst-free alkylation and acylation of benzothiazoles	17
B(C6F5)3-catalyzed O–H insertion reactions of diazoalkanes with phosphinic acids	17
Copper-catalyzed ortho-selective direct sulfenylation of N-aryl-7-azaindoles with disulfides	17
Deoxygenation reactions in organic synthesis catalyzed by dioxomolybdenum(vi) complexes	17
Cyrene: a bio-based solvent for the Mizoroki–Heck reaction of aryl iodides	17
Regioselective C–H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions	17
Phenanthrenequinone (PQ) catalyzed cross-dehydrogenative coupling of alkanes with quinoxalin-2(1H)-ones and simple N-heteroarenes under visible light irradiation	17
Difluoromethylarylation of α,β-unsaturated amides via a photocatalytic radical smiles rearrangement	17
The construction of benzimidazo[2,1-a]isoquinolin-6(5H)-ones from N-methacryloyl-2-phenylbenzoimidazoles through radical strategies	17
Friedel–Crafts arylation of aldehydes with indoles utilizing arylazo sulfones as the photoacid generator	17
Recent advances in photochemical construction of aromatic C–P bonds via C–hetero bond cleavage	17
Recent advances in the tandem copper-catalyzed Ullmann–GoldbergN-arylation–cyclization strategies	17
N-Heterocyclic carbene (NHC)-catalyzed intramolecular benzoin condensation–oxidation	17
Metal-free polychloromethyl radical-initiated cyclization of unactivated N-allylindoles towards pyrrolo[1,2-a]indoles	17
Electrocatalysis as a key strategy for the total synthesis of natural products	17
Base-mediated [3 + 2]-cycloannulation strategy for the synthesis of pyrazolo[1,5-a]pyridine derivatives using (E)-β-iodovinyl sulfones	17
Contemporary advancements in the semi-synthesis of bioactive terpenoids and steroids	17
Recent advances in the carbon–phosphorus (C–P) bond formation from unsaturated compounds by s- and p-block metals	17
The regioselective synthesis of 2,5- and 4,5-disubstituted thiazoles via the cyclization of 2-oxo-2-(amino)ethanedithioates with isocyanides	16
Donor acceptor fluorophores: synthesis, optical properties, TD-DFT and cytotoxicity studies	16
Synthesis of glycopeptides and glycopeptide conjugates	16
Dissipative control of the fluorescence of a 1,3-dipyrenyl calix[4]arene in the cone conformation	16
Polymeric nanostructures based on azobenzene and their biomedical applications: synthesis, self-assembly and stimuli-responsiveness	16
An air-stable, Zn2+-based catalyst for hydrosilylation of alkenes and alkynes	16
Visible-light-induced cyclization of cyclic N-sulfonyl ketimines to N-sulfonamide fused imidazolidines	16
Dibismuthanes in catalysis: from synthesis and characterization to redox behavior towards oxidative cleavage of 1,2-diols	16
Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins	16
Recent advances in the copper-catalyzed aerobic Csp3–H oxidation strategy	16
Photoinduced efficient synthesis of cyanoalkylsulfonylated oxindoles via sulfur dioxide insertion	16
Supramolecular brush polymers prepared from 1,3,4-oxadiazole and cyanobutoxy functionalised pillar[5]arene for detecting Cu2+	16
Cyclopenta-fused polyaromatic hydrocarbons: synthesis and characterisation of a stable, carbon-centred helical radical	16
Transition metal-free formal hydro/deuteromethylthiolation of unactivated alkenes	16
Electrocatalytic three-component synthesis of 4-halopyrazoles with sodium halide as the halogen source	16
l-Dopa in small peptides: an amazing functionality to form supramolecular materials	16