Computational Biology and Chemistry

Papers
(The TQCC of Computational Biology and Chemistry is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Integrated consensus genetic map and genomic scaffold re-ordering of oil palm (Elaeis guineensis) genome139
Decision tree classifier based on topological characteristics of subgraph for the mining of protein complexes from large scale PPI networks101
The interaction of methotrexate with the human C5a and its potential therapeutic implications72
Construction of the small intestine on molecular dynamics simulation and preliminary exploration of drug intestinal absorption prediction47
Computational investigations of indanedione and indanone derivatives in drug discovery: Indanone derivatives inhibits cereblon, an E3 ubiquitin ligase component43
Investigation of mesenchymal stem cell secretome on breast cancer gene expression: A bioinformatic approach to identify differentially expressed genes, functional networks, and potential therapeutic t40
Editorial Board37
Editorial Board34
Editorial Board33
Multi-scale DNA language model improves 6 mA binding sites prediction30
Identification of angiogenesis-related subtypes and risk models for predicting the prognosis of gastric cancer patients30
Computational insights into irinotecan's interaction with UBE2I in ovarian and endometrial cancers30
A novel parallel feature rank aggregation algorithm for gene selection applied to microarray data classification29
Prediction of human-Streptococcus pneumoniae protein-protein interactions using logistic regression28
Computational analysis of the interactions between Ebselen and derivatives with the active site of the main protease from SARS-CoV-226
New thiazolidine-2,4-diones as effective anti-proliferative and anti-VEGFR-2 agents: Design, synthesis, in vitro, docking, MD simulations, DFT, ADMET, and toxicity studies25
Implications of trinodal inhibitions and drug repurposing in MAPK pathway: A putative remedy for breast cancer25
Classical molecular dynamics simulation identifies catechingallate as a promising antiviral polyphenol against MPOX palmitoylated surface protein25
Editorial Board24
Netting into the Sophoretin pool: An approach to trace GSTP1 inhibitors for reversing chemoresistance24
Identification of oil palm cis-regulatory elements based on DNA free energy and single nucleotide polymorphism density24
Integrated regulatory network based on lncRNA-miRNA-mRNA-TF reveals key genes and sub-networks associated with dilated cardiomyopathy24
Comprehensive analyses of bioinformatics applications in the fight against COVID-19 pandemic24
Molecular insights into the mechanism of sugar-modified enkephalin binding to opioid receptors24
Bioinformatics analysis and verification of gene targets for renal clear cell carcinoma23
A global report on the dynamics of COVID-19 with quarantine and hospitalization: A fractional order model with non-local kernel23
Interactions between DNA and the acridine intercalator: A computational study23
Integrated structure-guided computational design of novel substituted quinolizin-4-ones as Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors22
MSFF-MA-DDI: Multi-Source Feature Fusion with Multiple Attention blocks for predicting Drug–Drug Interaction events22
SNSynergy: Similarity network-based machine learning framework for synergy prediction towards new cell lines and new anticancer drug combinations21
Inflammation inhibitory activity of green tea, soybean, and guava extracts during Sars-Cov-2 infection through TNF protein in cytokine storm21
Cerebral aneurysm evolution modeling from microstructural computational models to machine learning: A review19
Exploration of functional relations among differentially co-expressed genes identifies regulators in glioblastoma19
Thiazole inhibitors of α-glucosidase: Positional isomerism modulates selectivity, enzyme binding and potency of inhibition18
Computational analyses of the interactome between TNF and TNFR superfamilies18
Exploring the effectiveness of the TSR-based protein 3-D structural comparison method for protein clustering, and structural motif identification and discovery of protein kinases, hydrolases, and SARS18
Bisbenzylisoquinolines from Cissampelos pareira L. as antimalarial agents: Molecular docking, pharmacokinetics analysis, and molecular dynamic simulation studies18
Exploring fingerprints for antidiabetic therapeutics related to peroxisome proliferator-activated receptor gamma (PPARγ) modulators: A chemometric modeling approach18
SSA: Subset sum approach to protein β-sheet structure prediction17
STRIDER: Steric hindrance and metal coordination identifier17
Identification of calcineurin as a predictor of oocyte quality and fertilization competence based on microarray data17
Impact of calcium ions on the structural and dynamic properties of heparin oligosaccharides by computational analysis17
Tensor improve equivariant graph neural network for molecular dynamics prediction16
MD-UNET: Multi-input dilated U-shape neural network for segmentation of bladder cancer16
Amyloid β fibrils disruption by kolaviron: Molecular docking and extended molecular dynamics simulation studies16
RDDL: A systematic ensemble pipeline tool that streamlines balancing training schemes to reduce the effects of data imbalance in rare-disease-related deep-learning applications16
An efficient new method of ytterbium(III) triflate catalysis approach to the synthesis of substituted pyrroles: DFT, ADMET, and molecular docking investigations16
An assessment of crucial structural contributors of HDAC6 inhibitors through fragment-based non-linear pattern recognition and molecular dynamics simulation approaches16
BAT-Net: An enhanced RNA Secondary Structure prediction via bidirectional GRU-based network with attention mechanism16
Vector embeddings by sequence similarity and context for improved compression, similarity search, clustering, organization, and manipulation of cDNA libraries15
Comparative in Silico study of apigenin and its dimeric forms on PIM1 kinase in glioblastoma multiform15
FusPB-ESM2: Fusion model of ProtBERT and ESM-2 for cell-penetrating peptide prediction15
Gene-expression profile analysis to disclose diagnostics and therapeutics biomarkers for thyroid carcinoma15
Classification and prediction of variants associated with hearing loss using sequence information in the vicinity of mutation sites14
GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation14
Catalytic activity in vitro of the human protein kinase ASK1 mutants: Experimental and molecular simulation study14
Machine learning approaches for predicting craniofacial anomalies with graph neural networks14
Reliable estrogen-related prognostic signature for uterine corpus endometrial carcinoma14
P-FARFAR2: A multithreaded greedy approach to sampling low-energy RNA structures in Rosetta FARFAR214
An ensemble of bioinformatics and machine learning approaches to identify shared breast cancer biomarkers among diverse populations14
Graph-ETMB: A graph neural network-based model for tumour mutation burden estimation13
SME-MFP: A novel spatiotemporal neural network with multiangle initialization embedding toward multifunctional peptides prediction13
Targeting AR-positive breast cancer cells via drug repurposing approach13
Metaheuristics for multiple sequence alignment: A systematic review13
CopyMix: Mixture model based single-cell clustering and copy number profiling using variational inference13
Editorial Board12
Deep protein representations enable recombinant protein expression prediction12
Editorial12
A comprehensive investigation regarding the clinical significance of ITGB4 in oral squamous cell carcinoma combining immunohistochemistry, RNA-seq, and microarray data12
Modelling the transport mechanism of organic molecules into cell membranes: The role of organic solvents12
Apache Spark based kernelized fuzzy clustering framework for single nucleotide polymorphism sequence analysis11
Computational analysis of substrate recognition of Sars-Cov-2 Mpro main protease11
Editorial Board11
An assembling strategy for DNA cages with minimum strands11
A computational study of structural analysis of Class I human glucose-6-phosphate dehydrogenase (G6PD) variants: Elaborating the correlation to chronic non-spherocytic hemolytic anemia (CNSHA)11
Human drug-pathway association prediction based on network consistency projection11
Discovery of small-molecule PD-1/PD-L1 antagonists through combined virtual screening and experimental validation11
Transcriptome analysis reveals mechanisms of metabolic detoxification and immune responses following farnesyl acetate treatment in Metisa plana11
UmamiPreDL: Deep learning model for umami taste prediction of peptides using BERT and CNN10
A computational essential dynamics approach to investigate structural influences of ligand binding on Papain like protease from SARS-CoV-210
Machine learning and molecular subtyping reveal the impact of diverse patterns of cell death on the prognosis and treatment of hepatocellular carcinoma10
A composite ranking of risk factors for COVID-19 time-to-event data from a Turkish cohort10
Deep2Pep: A Deep Learning Method in Multi-label Classification of Bioactive Peptide10
Integrated deep learning model for automatic detection and classification of stenosis in coronary angiography10
scDGG: Dynamic Gene Graphs for enhancing spatial and temporal analysis of single-cell RNA sequencing data10
The marijuana-schizophrenia multifaceted nexus: Connections and conundrums towards neurophysiology10
Identification of phytoestrogens as sirtuin inhibitor against breast cancer: Multitargeted approach10
Fractional whale driving training-based optimization enabled transfer learning for detecting autism spectrum disorder10
Computational exploration of Ganoderma lucidum metabolites as potential anti-atherosclerotic agents: Insights from molecular docking and dynamics simulations10
Synthesis, structural elucidation, DFT calculation, biological studies and DNA interaction of some aryl hydrazone Cr3+, Fe3+, and Cu2+ chelates10
A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19)9
MMR: A Multi-view Merge Representation model for Chemical-Disease relation extraction9
Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance9
ACDMBI: A deep learning model based on community division and multi-source biological information fusion predicts essential proteins9
Antihyperlipidemic mechanisms of a formula containing Curcuma xanthorrhiza, Sechium edule, and Syzigium polyanthum: In silico and in vitro studies9
Towards development of new antimalarial compounds through in silico and in vitro assays9
CNVABNN: An AdaBoost algorithm and neural networks-based detection of copy number variations from NGS data9
LPI-CSFFR: Combining serial fusion with feature reuse for predicting LncRNA-protein interactions9
Integrating multiple sequence features for identifying anticancer peptides9
Identifying potential Alzheimer's disease therapeutics through GSK-3β inhibition: A molecular docking and dynamics approach9
Osmotic pressure induced by extracellular matrix drives Bacillus subtilis biofilms' self-healing9
ANNInter: A platform to explore ncRNA-ncRNA interactome of Arabidopsis thaliana9
Using a dual immunoinformatics and bioinformatics approach to design a novel and effective multi-epitope vaccine against human torovirus disease9
Chemogenomic approach to identifying nematode chemoreceptor drug targets in the entomopathogenic nematode Heterorhabditis bacteriophora9
Editorial Board9
Acknowledgements to 2019 Reviewers8
Designing, DFT, biological, & molecular docking analysis of new Iron(III) & copper(II) complexes incorporating 1-{[-(2-Hydroxyphenyl)methylene]amino}−5,5-diphenylimidazolidine-2,4-dione (PHNS)8
In silico profiling, docking analysis, and protein interactions of secondary metabolites in Musa spp. Against the SGE1 protein of Fusarium oxysporum f. sp. cubense8
Enhancing gene regulatory networks inference through hub-based data integration8
ACP-ESM2: The prediction of anticancer peptides based on pre-trained classifier8
Designing, characterization, biological, DFT, and molecular docking analysis for new FeAZD, NiAZD, and CuAZD complexes incorporating 1-(2-hydroxyphenylazo)− 2-naphthol (H2AZD)8
ActTRANS: Functional classification in active transport proteins based on transfer learning and contextual representations8
Role of surface-exposed charged basic amino acids (Lys, Arg) and guanidination in insulin on the interaction and stability of insulin–insulin receptor complex8
Computational analysis revealed miRNAs produced by Chikungunya virus target genes associated with antiviral immune responses and cell cycle regulation8
A Boolean model of the oncogene role of FAM111B in lung adenocarcinoma8
TopMarker: Computational screening biomarkers of hepatocellular carcinoma from transcriptome and interactome based on differential network topological parameters8
Dual computational and biological assessment of some promising nucleoside analogs against the COVID-19-Omicron variant8
Identification and validation of miR-21 key genes in cervical cancer through an integrated bioinformatics approach8
Correlation intensity index-index of ideality of correlation: A hyphenated target function for furtherance of MAO-B inhibitory activity assessment8
Statistical analysis of the unique characteristics of secondary structures in proteins8
In silico exploration of CB2 receptor agonist in the management of neuroinflammatory conditions by pharmacophore modeling7
Transcription factors and chaperone proteins play a role in launching a faster response to heat stress and aggregation7
Designing of thiazolidinones against chicken pox, monkey pox, and hepatitis viruses: A computational approach7
Intrinsic relative preference profile of pan-kinase inhibitor drug staurosporine towards the clinically occurring gatekeeper mutations in Protein Tyrosine Kinases7
Integrated in silico and experimental discovery of trimeric peptide ligands targeting Butyrylcholinesterase7
A structure-based approach to discover a potential isomerase Pin1 inhibitor for cancer therapy using computational simulation and biological studies7
Investigating Lycotoxin-An1a (An1a), a defense antiviral peptide from Alopecosa nagpag venom as prospective anti-dengue agent against DENV-2 NS2B-NS3 protease7
Exploring of antioxidant and antibacterial properties of novel 1,3,4-thiadiazole derivatives: Facile synthesis, structural elucidation and DFT approach to antioxidant characteristics7
Exploring potential molecular targets and therapeutic efficacy of beauvericin in triple-negative breast cancer cells7
Mining channel-regulated peptides from animal venom by integrating sequence semantics and structural information7
Integrative bioinformatics analysis of immune activation and gene networks in pediatric septic arthritis7
Editorial Board7
Novel 1,4 benzothiazine 3-one derivatives as anticonvulsant agents: Design, synthesis, biological evaluation and computational studies7
Robust biomarker screening from gene expression data by stable machine learning-recursive feature elimination methods7
The prevalence of dementia in humans could be the result of a functional adaptation7
DeepOCR: A multi-species deep-learning framework for accurate identification of open chromatin regions in livestock7
Rational design of antimicrobial peptides targeting Gram-negative bacteria7
High-throughput virtual screening and microsecond MD simulations to identify potential sugar mimic of the solute-binding protein BlAXBP of the ABC transporter from Bifidobacterium animalis subsp. Lact7
Prediction of protein structural class based on symmetrical recurrence quantification analysis7
Machine learning and molecular simulation ascertain antimicrobial peptide against Klebsiella pneumoniae from public database7
A deep-SIQRV epidemic model for COVID-19 to access the impact of prevention and control measures7
Cancer detection with various classification models: A comprehensive feature analysis using HMM to extract a nucleotide pattern7
Exploring casual effects and shared molecular mechanism between psoriasis and liver cancer through Mendelian randomization and comprehensive bioinformatic analyses7
Exploring enzyme inhibition profiles of novel halogenated chalcone derivatives on some metabolic enzymes: Synthesis, characterization and molecular modeling studies7
Green synthesis of selenium based N-heterocyclic carbene compounds; structural, in-vitro anticancer and molecular docking studies7
SE-BLTCNN: A channel attention adapted deep learning model based on PSSM for membrane protein classification7
16S amplicon sequencing and functional gene prediction of microbial community in Inner West Aegean, Turkey7
Investigating pH-induced conformational switch in PIM-1: An integrated multi spectroscopic and MD simulation study7
Prognostic significance of a 3-gene ferroptosis-related signature in lung cancer via LASSO analysis and cellular functions of UBE2Z7
Visualization of UV and ECD spectra of E&Z isomers of N-(4′-Hydroxy-cinnamoyl)− 5- hydroxyanthranilic acid7
Unveiling novel type 1 inhibitors for targeting LIM kinase 2 (LIMK2) for cancer therapeutics: An integrative pharmacoinformatics approach7
Investigation of dual inhibition of antibacterial and antiarthritic drug candidates using combined approach including molecular dynamics, docking and quantum chemical methods7
Co-expression network and survival analysis of breast cancer inflammation and immune system hallmark genes7
ARGai 1.0: A GAN augmented in silico approach for identifying resistant genes and strains in E. coli using vision transformer6
Uncovering the antidiabetic potential of heart-friendly and diuretic bioactive compounds through computer-based drug design6
Design, synthesis, In-vitro, In-silico and DFT studies of novel functionalized isoxazoles as antibacterial and antioxidant agents6
Reconstruction of the binding pathway of an anti-HIV drug, Indinavir, in complex with the HTLV-1 protease using unaggregated unbiased molecular dynamics simulation6
Virtual screening of polyherbal compounds for AKT1 and HSPB1 inhibition in breast cancer apoptosis pathway6
Screening of the effective sites of Cichorium glandulosum against hyperuricemia combined with hyperlipidemia and its network pharmacology analysis6
Multiscale modeling of the cellular uptake of C6 peptide-siRNA complexes6
IoT based healthcare system using fractional dung beetle optimization enabled deep learning for breast cancer classification6
Theoretical Investigations of a point mutation affecting H5 Hemagglutinin’s receptor binding preference6
Encoding the space of protein-protein binding interfaces by artificial intelligence6
Halting aberrant DNA methylation via in silico Identification of potent inhibitors of DNMT3B enzyme: Atomistic insights6
Integrated computational approaches for designing potent pyrimidine-based CDK9 inhibitors: 3D-QSAR, docking, and molecular dynamics simulations6
Real-to-bin conversion for protein residue distances6
An open source in silico workflow to assist in the design of fusion proteins6
In silico analysis and prediction of transcription factors of the proteins interacting with astrocyte elevated gene-16
Acknowledgements to 2020 Reviewers6
AMPCDA: Prediction of circRNA–disease associations by utilizing attention mechanisms on metapaths6
Lycopene destabilizes preformed Aβ fibrils: Mechanistic insights from all-atom molecular dynamics simulation6
Cellular and molecular level host-pathogen interactions in Francisella tularensis: A microbial gene network study6
Pharmacoinformatics-based prediction of Checkpoint kinase-1 inhibitors from Momordica charantia Linn. for cancer6
K1K2NN: A novel multi-label classification approach based on neighbors for predicting COVID-19 drug side effects6
Molecular dynamic simulation analysis of SARS-CoV-2 spike mutations and evaluation of ACE2 from pets and wild animals for infection risk6
Ensembling machine learning models to boost molecular affinity prediction6
The method predicting interaction between protein targets and small-molecular ligands with the wide applicability domain6
Harnessing the druggability at orthosteric and allosteric sites of PD-1 for small molecule discovery by an integrated in silico pipeline6
Design and characterization of defined alpha-helix mini-proteins with intrinsic cell permeability5
A novel prognostic risk score model based on RNA editing level in lower-grade glioma5
Editorial Board5
Targeting cyclin-dependent kinase 2 CDK2: Insights from molecular docking and dynamics simulation – A systematic computational approach to discover novel cancer therapeutics5
Vaginal birth after cesarean section prediction model for Jordanian population5
Where is the mind within the brain? Transient selection of subnetworks by metabotropic receptors and G protein-gated ion channels5
N-glycosylation reinforces interaction of immune checkpoint TIM-3 with a small molecule ligand5
Design and In-silico study of bioimaging fluorescence Graphene quantum dot-Bovine serum albumin complex synthesized by diimide-activated amidation5
FPDock: Protein–protein docking using flower pollination algorithm5
Comments on 'Flexibility of enzymatic transitions as a hallmark of optimized enzyme steady-state kinetics and thermodynamics'5
Non-homogeneous Poisson and renewal processes as spatial models for cancer mutation5
Exploring the interaction of phytochemicals from Hibiscus rosa-sinensis flowers with glucosidase and acetylcholinesterase: An integrated in vitro and in silico approach5
In silico identification of candidate miRNA-encoded Peptides in four Fabaceae species5
Non-kin selection enhances complexity in cooperation: A unified quantitative law5
Halogenated class of oximes as a new class of monoamine oxidase-B inhibitors for the treatment of Parkinson’s disease: Synthesis, biochemistry, and molecular dynamics study5
Efficient assembly consensus algorithms for divergent contig sets5
Editorial Board5
Terpenoid phytocompounds from mangrove plant Xylocarpus moluccensis as possible inhibitors against SARS-CoV-2: In silico strategy5
Protein function prediction using functional inter-relationship5
Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains5
Cytokine expression patterns: A single-cell RNA sequencing and machine learning based roadmap for cancer classification5
DeepRHD: An efficient hybrid feature extraction technique for protein remote homology detection using deep learning strategies5
Exploring the value of pleural fluid biomarkers for complementary pleural effusion disease examination5
Convolutional neural networks with image representation of amino acid sequences for protein function prediction5
Integrating classic AI and agriculture: A novel model for predicting insecticide-likeness to enhance efficiency in insecticide development5
CTDN (Convolutional Temporal Based Deep‐ Neural Network): An Improvised Stacked Hybrid Computational Approach for Anticancer Drug Response Prediction5
Glycosylation is key for enhancing drug recognition into spike glycoprotein of SARS-CoV-25
OTUCD: Unsupervised GCN based metagenomics non-overlapping community detection5
Bipartite molecular approach for species delimitation and resolving cryptic speciation of Exobasidium vexans within the Exobasidium genus5
Sub-structure-based screening and molecular docking studies of potential enteroviruses inhibitors5
Profiling the structural determinants of pyrrolidine derivative as gelatinases (MMP-2 and MMP-9) inhibitors using in silico approaches5
Transfer learning with molecular graph convolutional networks for accurate modeling and representation of bioactivities of ligands targeting GPCRs without sufficient data5
Advancing Drug-Target Interaction prediction with BERT and subsequence embedding5
Differentiating stable and unstable protein using convolution neural network and molecular dynamics simulations5
An efficient Burrows–Wheeler transform-based aligner for short read mapping5
ETENLNC: An end to end lncRNA identification and analysis framework to facilitate construction of known and novel lncRNA regulatory networks5
TSSUNet-MB – ab initio identification of σ70 promoter transcription start sites in Escherichia coli using deep multitask learning5
Ligand binding free energy evaluation by Monte Carlo Recursion5
Planning biosynthetic pathways of target molecules based on metabolic reaction prediction and AND-OR tree search5
GEHGAN: CircRNA–disease association prediction via graph embedding an5
Effects of 1,4-dihydropyridine derivatives on cell injury and mTOR of HepG2 and 3D-QSAR study5
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