Veterinary and Comparative Oncology

Article	Citations
Identification of potential plasma protein biomarkers for feline pancreatic carcinoma by liquid chromatography tandem mass spectrometry	141
Issue Information	17
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Issue Information	15
Author Index	14
Visualizing the cancer stem‐like properties of canine tumour cells with low proteasome activity	14
Abstracts	14
Evaluation of serum interleukin 2 receptor and beta‐2‐microglobulin as prognostic factors for canine lymphoma: A pilot study	13
Issue Information	13
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Editorial	12
Diagnostic accuracy of optical coherence tomography for surgical margin assessment of feline injection‐site sarcoma	12
Facilitating stakeholder involvement in Comparative Oncology research: A qualitative analysis of key stakeholder opinions and perceptions	11
Description and efficacy of a response‐based “QUAD” cyclical hypofractionated palliative‐intent radiation protocol in dogs with macroscopic solid tumours: 108 cases	11
Multi‐institutional retrospective study of canine foot pad malignant melanomas: 20 cases	10
High lysyl oxidase expression is an indicator of poor prognosis in dogs with cutaneous mast cell tumours	10
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Serum thymidine kinase 1 activity as a prognostic biomarker in dogs with chemotherapy‐treated diffuse large B‐cell lymphoma	9
Canine presumed glial brain tumours treated with radiotherapy: Is there an inferior outcome in tumours contacting the subventricular zone?	9
Outcomes of 35 dogs with craniomaxillofacial osteosarcoma treated with stereotactic body radiation therapy	9
There and back again: Translating adoptive cell therapy to canine cancer and improving human treatment	9
Effects of a high‐protein, increased‐fibre, dry diet supplemented with omega‐3 fatty acids on quality of life in dogs undergoing chemotherapy	9
Ultrasound‐guided core needle biopsy in dogs with thyroid carcinoma	9
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Canine squamous cell carcinoma: Electrochemotherapy association with surgery and correlation with overall survival	8

BRAF mutation status and its prognostic significance in 79 canine urothelial carcinomas: A retrospective study (2006–2019)	8
Investigation of efficacy of two different chemotherapy protocols used in neoadjuvant chemotherapy in clinical stages II–IV canine malignant mammary tumours	8
Sodium iodide symporter immunolabelling as a predictor of clinical iodide uptake in canine thyroid carcinoma: A preliminary study	8
Inter‐pathologist agreement on diagnosis, classification and grading of canine glioma	7
Timely adjuvant chemotherapy improves outcome in dogs with non‐metastatic splenic hemangiosarcoma undergoing splenectomy	7
Abstracts	7
Characterizing the metabolic role of STAT3 in canine osteosarcoma	7
Characterization and function of extracellular vesicles in a canine mammary tumour cell line: Ultracentrifugation versus size exclusion chromatography	7
Feasibility and safety of whole lung irradiation in the treatment of canine appendicular osteosarcoma	7
Evaluation of the anti‐tumour activity of Coriolus versicolor polysaccharopeptide (I'm‐Yunity) alone or in combination with doxorubicin for canine splenic hemangiosarcoma	7
Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence	7
Risk factors influencing death prior to discharge in 302 dogs undergoing unilateral adrenalectomy for treatment of primary adrenal gland tumours	7
A retrospective comparison of first and second opinion histopathology with patient outcomes in veterinary oncology cases (2011–2019)	7
Sentinel lymph node mapping in canine mast cell tumours using a preoperative radiographic indirect lymphography: Technique description and results in 138 cases	6
Distribution of Inflammatory Infiltrate in Feline Mammary Lesions: Relationship With Clinicopathological Features	6
Inhibitory checkpoint molecule mRNA expression in canine soft tissue sarcoma	6
Treatment of feline intermediate to high‐grade alimentary lymphoma: A retrospective evaluation of 55 cats treated with the VAPC combination chemotherapy protocol (2017–2021)	6
Comparison of response assessment in veterinary neuro‐oncology and two volumetric neuroimaging methods to assess therapeutic brain tumour responses in veterinary patients	6
Comparison of Three Chemotherapy Protocols With Electrochemotherapy for the Treatment of Feline Cutaneous Squamous Cell Carcinoma	6
Targeting ATR Kinase as a Strategy for Canine Lymphoma and Leukaemia Treatment	6
Stereotactic body radiation therapy as an alternative to adrenalectomy for the treatment of pheochromocytomas in 8 dogs	6
Comparative gene expression study highlights molecular similarities between triple negative breast cancer tumours and feline mammary carcinomas	6
Patterns of metastatic progression and association with clinical outcomes in canine osteosarcoma: A necropsy study of 83 dogs	6
Isolation of Tumour‐Derived Extracellular Vesicles From the Plasma of Dogs Affected by Intracranial Tumours Showing Heterologous and Cross‐Species Tropism: A Pilot Study	6
Stereotactic Radiation Therapy Planning, Dose Prescription and Delivery in Veterinary Medicine: A Systematic Review on Completeness of Reporting and Proposed Reporting Items	5
Stromal Expression Profiling Reveals Immune‐Driven Adaption to Malignancy in Canine Melanoma Subtypes	5
Procarbazine, prednisolone and cyclophosphamide oral combination chemotherapy protocol for canine lymphoma	5
The role of toceranib phosphate in dogs with non‐mast cell neoplasia: A systematic review	5
Clinical Utility of Circulating Cell‐Free DNA as a Liquid Biopsy in Cats With Various Tumours	5
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Impact of 10% Dose Reductions and Duration of Treatment Delays in the Management of Chemotherapy‐Induced Neutropenia in Dogs Treated With Common Chemotherapy Protocols: A Single‐Centre Experience	5
A retrospective analysis of 11 dogs with surface osteosarcoma	5
Extracellular heat shock protein 70 levels in tumour‐bearing dogs and cats treated with radiation therapy and hyperthermia	5
A Retrospective Study Evaluating the Outcomes of Conventionally Fractionated Radiation Therapy as a Treatment for Infiltrative Lipomas in Twenty‐One Dogs	5
Ovariectomy reduces the risk of tumour development and influences the histologic continuum in canine mammary tumours	5
Peritumoral Edema in Canine Extra‐Axial Brain Tumours: Effect of Steroids	5
Long‐term survival of dogs with stage 4 oral malignant melanoma treated with anti‐canine PD‐1 therapeutic antibody: A follow‐up case report	5
Electrochemotherapy in dogs and cats–A review	5
Lymphotropic nanoparticle magnetic resonance imaging for diagnosing metastatic lymph nodes in dogs with malignant head and neck tumours	5
Surgical and oncologic outcomes in dogs with malignant peripheral nerve sheath tumours arising from the brachial or lumbosacral plexus	5
Descriptive analysis of haemangiosarcoma occurrence in dogs enrolled in the Golden Retriever lifetime study	4
Mass spectrometric‐based assessment of the serum kappa to lambda immunoglobulin light chain ratio (κ:λ) in dogs with immunoglobulin secretory diseases	4
Author Index	4
Safety and feasibility of short course pre‐operative radiation therapy followed by surgical excision for canine solid tumours	4
Leading the pack: Best practices in comparative canine cancer genomics to inform human oncology	4
Cyclical 10‐day dosing of melphalan for canine multiple myeloma	4
Dysregulated miRNAs in a canine model of haemangiosarcoma metastatic to the brain	4
Establishment of a new cell line of canine inflammatory mammary cancer: IMC‐118	4
Pre‐operative neoadjuvant vinblastine‐prednisolone in canine mast cell tumours: A single‐centre retrospective cohort study	4
Practice patterns about the role of palliation in veterinary surgical oncology	4

Staging canine patients with appendicular osteosarcoma utilizing fluorine‐18 fluorodeoxyglucose positron emission tomography/computed tomography compared to whole body computed tomography	4
A multi‐institutional epidemiologic study evaluating environmental risk factors for feline oral squamous cell carcinoma	4
Mastocytosis in the skin in dogs: A multicentric case series	4
Issue Information	4
Local tumour nanoparticle thermal therapy: A promising immunomodulatory treatment for canine cancer	4
Characterization of the dissemination of canine cancer misinformation on YouTube	3
Plasma cell‐free DNA in canine lymphoma patients as a novel material for genotyping	3
Novel surgical approach to neoplastic lesions in the distal part of the urethra: A pilot cadaver study comparing open and hybrid techniques	3
Liquid biopsy can detect BRCA2 gene variants in female dogs with mammary neoplasia	3
KIT mutations in mast cell tumours from cheetahs (Acinonyx jubatus) and domestic cats (Felis catus)	3
Antioxidant 1 copper chaperone gene expression and copper levels in dog osteosarcoma patients	3
Outcome of dogs with bone marrow suppression secondary to Sertoli cell tumour	3
Immunohistochemical and transcriptomic characterization of T and myeloid cell infiltrates in canine malignant melanoma	3
Prophylactic Antimicrobials for Prevention of Febrile Neutropenia in Tumour‐Bearing Dogs Treated With Lomustine	3
Blood biomarkers for canine cancer, from human to veterinary oncology	3
Evaluation of the therapeutic potential of masitinib and expression of its specific targets c‐Kit, PDGFR‐α, PDGFR‐β, and Lyn in canine prostate cancer cell lines	3
Outcome of dogs treated with chemotherapy for mesothelioma: A retrospective clinical study on 40 cases and a literature review	3
SLUG is upregulated and induces epithelial mesenchymal transition in canine oral squamous cell carcinoma	3
Immunohistochemical Expression of Programmed Death‐Ligand 1 and Cytotoxic T‐Lymphocyte Antigen‐4 in Canine Cutaneous Mast Cell Tumours	3
Regulation of programmed death ligand 1 expression by interferon‐γ and tumour necrosis factor‐α in canine tumour cell lines	3
Expression and therapeutic targeting of BMI1 in canine gliomas	3
Developing a translational murine‐to‐canine pathway for anIL‐2/agonistanti‐CD40antibody cancer immunotherapy	3
Efficacy and adverse events of continuousl‐asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin	3
Oncolytic effect of Newcastle disease virus is attributed to interferon regulation in canine mammary cancer cell lines	3
Outcomes of Stereotactic Radiation Therapy Versus Fractionated Radiation Therapy in 44 Dogs With Pituitary Masses: A Multi‐Institutional Retrospective Study (2016–2022)	3
Evaluating the relevance of surgical margins. Part one: The problems with current methodology	3
Canine anal sac gland carcinoma with regional lymph node metastases treated with sacculectomy and lymphadenectomy: Outcome and possible prognostic factors	3
Correlation between computed tomography and histological evaluation of nodal metastasis in dogs with mast cell tumours	3
Correction to: Retrospective analysis of outcome and prognostic factors of subcutaneous mast cell tumours in dogs undergoing surgery with or without adjuvant treatment	3
Standardisation of canine meningioma grading: Inter‐observer agreement and recommendations for reproducible histopathologic criteria	3
Lymphoid Aggregates in Canine Cutaneous and Subcutaneous Sarcomas: Immunohistochemical and Gene Expression Evidence for Tertiary Lymphoid Structures	3
Risk factors associated with the onset of lomustine‐induced neutropenia in tumour‐bearing dogs	3
Combining radiation therapy with zoledronate for the treatment of osteo‐invasive feline oral squamous cell carcinoma	3
The use of ‘trend’ statements in veterinary oncology literature	2
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Evaluation of clinical response and prognostic factors in canine multicentric lymphoma treated with first rescue therapy	2
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Are severe adverse events commonly observed in dogs during cancer chemotherapy? A retrospective study on 155 dogs	2
Exploring optical coherence tomography imaging depth to differentiate tissues at surgical margins	2
Impact of palliative‐intent radiotherapy with or without chemotherapy on lameness in flat coat retrievers with localised periarticular histiocytic sarcoma – a retrospective cohort, single institution	2
Outcome with surgical treatment of canine soft tissue sarcoma in the region of the ischiatic tuberosity: A veterinary society of surgical oncology retrospective study	2
Alternating rabacfosadine and doxorubicin for treatment of naïve canine lymphoma	2
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VCS abstract	2
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Effect of contrast agent viscosity and massage on success of computed tomography lymphangiography with aqueous contrast for sentinel lymph node identification in healthy dogs	2
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Large granular lymphocyte lymphoma in 65 dogs (2005–2023)	2
Molecular differences in mitochondrial DNA genomes of dogs with malignant mammary tumours	2
Chronic adrenergic stress and generation of myeloid‐derived suppressor cells: Implications for cancer immunotherapy in dogs	2
Clinical presentation, treatment and outcome of canine malignant mesothelioma: A retrospective study of 34 cases	2
Retrospective assessment of radiation toxicity from a definitive‐intent, moderately hypofractionated image‐guided intensity‐modulated protocol for anal sac adenocarcinoma in dogs	2
Determining agreement between preoperative computed tomography lymphography and indocyanine green near infrared fluorescence intraoperative imaging for sentinel lymph node mapping in dogs with oral tu	2
Veterinary Cooperative Oncology Group—Common Terminology Criteria for Adverse Events (VCOG‐CTCAE v2) following investigational therapy in dogs and cats	2
Issue Information	2
A retrospective study of 101 dogs with oral melanoma treated with a weekly or biweekly 6 Gy × 6 radiotherapy protocol	2
Molecular phenotyping of malignant canine mammary tumours: Detection of high‐risk group and its relationship with clinicomolecular characteristics	2
Monoclonal antibody cetuximab impairs matrix metalloproteinases 2 and 9, epithelial–mesenchymal transition and cell migration in feline oral squamous cell carcinoma in vitro	2
Focused ultrasound tumour ablation in small animal oncology	2
Optical coherence tomography for surgical margin evaluation of excised canine cutaneous and subcutaneous tumours	2
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ESVONC abstracts	1
Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC	1
Issue Information	1
DNA damage response proteins in canine cancer as potential research targets in comparative oncology	1
Efficacy and toxicity of carboplatin in the treatment of macroscopic mesenchymal neoplasia in dogs	1
PD‐L1, PD‐1, and CTLA‐4 mRNA In Situ Expression by Canine Oral Melanoma Cells and Immune Cells of the Tumour Microenvironment	1
Correction to: Standardization of canine meningioma grading: Inter‐observer agreement and recommendations for reproducible histopathologic criteria	1
Issue Information	1
Sentinel lymph node mapping with computed tomography lymphography for mast cell tumours and a comparison between regional and sentinel lymph node histological status: Sixty‐two cases	1
Outcomes and Perioperative Complications of Surgical Resection on Canine Carotid Paragangliomas (21 Cases): A Veterinary Society of Surgical Oncology Study	1
Calculation of dose intensity and comparison of published methods using a cohort of canine T‐cell lymphoma patients undergoing CHOP‐based chemotherapy	1
Use of Cystourethroscopy to Define the Gross Tumour Volume in Radiation Treatment Planning for Canine Genitourinary Carcinomas	1
Newcastle disease virus LaSota strain induces apoptosis and activates the TNFα/NF‐κB pathway in canine mammary carcinoma cells	1
Evaluation of lymphocyte‐specific programmed cell death protein 1 receptor expression and cytokines in blood and urine in canine urothelial carcinoma patients	1
Prostaglandin EP4 receptor mRNA expression in canine lymphoma	1
Comparison of pathologist review protocols for cytologic detection of prostatic and urothelial carcinomas in canines: A bi‐institutional retrospective study of 298 cases	1
Author Index	1
A multi‐centre prospective evaluation of internet research habits among owners seeing a veterinary oncologist	1

Splenic stromal sarcomas in dogs: Outcome and clinicopathological prognostic factors in 32 cases	1
Correction to “DNA Methylation and Its Effects on TRIM29 Gene Expression in the Equine Sarcoid Tissue”	1
Corrigendum	1
Issue Information	1
Effects of Lipophilic Statins on Cell Viability and Tissue Factor Expression in Canine Haemangiosarcoma Cells	1
Neutrophil‐to‐lymphocyte ratio is an independent prognostic marker for feline mammary carcinomas	1
Auranofin Suppresses the Growth of Canine Mammary Tumour Cells and Induces Apoptosis via the PI3K/AKT Pathway	1
Characterizing the molecular and immune landscape of canine bladder cancer	1
Canine Oncopanel: A capture‐based, NGS platform for evaluating the mutational landscape and detecting putative driver mutations in canine cancers	1
Author Index	1
Clinical outcomes in cats with renal carcinoma undergoing nephrectomy: A retrospective study	1
Histologic grade has a higher‐weighted value than nodal status as predictor of outcome in dogs with cutaneous mast cell tumours and overtly metastatic sentinel lymph nodes	1
Expression of Concern: Tumour necrosis factor‐alpha‐induced protein 8 (TNFAIP8) expression associated with cell survival and death in cancer cell lines infected with canine distemper virus	1
A relatively high proportion of dogs with small apocrine gland anal sac adenocarcinoma (AGASACA) primary tumours present with locoregional lymph node metastasis	1
Issue Information	1
The mitotic regulator polo‐like kinase 1 as a potential therapeutic target for c‐Myc‐overexpressing canine osteosarcomas	1
Immunological Pre‐Metastatic Niche in Dogs With Naturally Occurring Osteosarcoma	1
Response of canine thyroid carcinomas to radioiodine	1
Issue Information	1
Evaluation of prognostic impact of pre‐treatment neutrophil to lymphocyte and lymphocyte to monocyte ratios in dogs with oral malignant melanoma treated with surgery and adjuvantCSPG4‐antig	1
Author Index	1
Validation of oral brushing as a non‐invasive technique for the identification of feline oral squamous cell carcinoma by DNA methylation and TP53 mutation analysis	0
Standardization of canine meningioma grading: Validation of new guidelines for reproducible histopathologic criteria	0
Prognostic indicators for naïve canine non‐indolent T‐cell lymphoma treated with combination lomustine, vincristine, procarbazine and prednisolone chemotherapy	0
Surgical complications following sentinel lymph node biopsy guided by γ‐probe and methylene blue in 113 tumour‐bearing dogs	0
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The prevalence of intra‐tumoral and distant thrombi, as well as tumour‐cell emboli in canine neoplasia	0
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Genetic variants of BRCA1 and BRCA2 genes in cats with mammary gland carcinoma	0
Issue Information	0
Tumour necrosis factor stimulated gene 6 intrinsically regulates PD‐L1 expressions in breast cancer cells, leading to modulation of tumour microenvironment	0
Total laryngectomy and permanent tracheostomy in six dogs	0
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ESVONC abstracts	0
Flow Cytometry for the Detection and Quantification of Mast Cells in Lymph Nodes: A Prospective Study in 64 Dogs With Mast Cell Tumour	0
Establishment of aBRAF V595E‐mutant canine prostate cancer cell line and the antitumor effects ofMEKinhibitors against canine prostate cancer	0
Minimally invasive ethyl cellulose ethanol ablation in domesticated cats with naturally occurring head and neck cancers: Six cats	0
Response‐based modification of CHOP chemotherapy for canine B‐cell lymphoma	0
Retrospective evaluation of toceranib phosphate (Palladia) in the treatment of canine carcinomatosis and mesothelioma	0
A newly established canine NK‐type cell line and its cytotoxic properties	0
Precision in Parsing: Evaluation of an Open‐Source Named Entity Recognizer (NER) in Veterinary Oncology	0
Outcome in dogs with curative‐intent treatment of localized primary pulmonary histiocytic sarcoma	0
Effective detection of BRAFV595E mutation in canine urothelial and prostate carcinomas using immunohistochemistry	0
Axillary lymphadenectomy in dogs: A description of surgical technique	0
Toosendanin‐induced apoptosis of CMT‐U27 is mediated through the mitochondrial apoptotic pathway	0
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CDC6: A novel canine tumour biomarker detected in circulating extracellular vesicles	0
Comparative Transcriptomes of Canine and Human Prostate Cancers Identify Mediators of Castration Resistance	0
Molecular characterization of canine SHP2 mutants and anti‐tumour effect of SHP2 inhibitor, SHP099, in a xenograft mouse model of canine histiocytic sarcoma	0
Elevated expression of miR‐301a and its functional roles in canine oral melanoma	0
Expression of mPGES1 and p16 in feline and human oral squamous cell carcinoma: A comparative oncology approach	0
Correction to: Standardization of canine meningioma grading: Validation of new guidelines for reproducible histopathologic criteria	0
Genomic analysis across 53 canine cancer types reveals novel mutations and high clinical actionability potential	0
Outcome and postoperative complications in 73 dogs with thyroid carcinoma with gross vascular invasion managed with thyroidectomy	0
Vincristine Induced Adverse Effects in Lymphoma Bearing Dogs With Asymptomatic Neutropenia at the Time of Drug Administration	0
Issue Information	0
Histologic, Phenotypic, and Molecular Characterization of Feline Hodgkin‐Like Lymphoma With Classical Reed‐Sternberg Cells	0
Overactivation of Signal Transducer and Activator of Transcription 3 in Canine Hepatocellular Carcinoma and Its Prognostic Significance	0
Issue Information	0
Incorporation of Biologic Variables Into the Staging for Canine Cutaneous and Subcutaneous Mast Cell Tumours: Proposal of the UBo pTNM System	0
Treatment of myeloid neoplasia with doxorubicin and cytarabine in 11 dogs	0
The prognostic significance of metabolic tumour volume and total lesion glycolysis for dogs staged for appendicular osteosarcoma with fluorine‐18 fluorodeoxyglucose positron emission tomography/comput	0
Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component	0
Issue Information	0
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Evaluation of the Amount of Compounded Chemotherapy Drugs: A Comparison Between Nine Compounding Pharmacies	0
Clinical outcome of dogs diagnosed with canine inflammatory mammary cancer treated with metronomic cyclophosphamide, a cyclooxygenase‐2 inhibitor and toceranib phosphate	0
The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression	0
Post‐operative complications following apocrine gland anal sac adenocarcinoma resection in dogs	0
Editorial	0
A retrospective Italian Society of Veterinary Oncology (SIONCOV) study of 56 cats with appendicular osteosarcoma	0
Pilot study to evaluate isolation by size of circulating tumour cells in canine oral melanoma	0
Configuration of pathologic fractures in dogs with osteosarcoma following stereotactic body radiation therapy: A retrospective analysis	0
Increased incidence of gastrointestinal toxicity in canine cancer patients treated with concurrent abdominal radiation therapy and toceranib phosphate	0
Issue Information	0
Relative Tumour Volume in Canine Oral Melanoma Staging and Prognosis	0
Do Pre‐Treatment Biopsy Characteristics Predict Early Tumour Progression in Feline Diffuse Large B Cell Nasal Lymphoma Treated With Radiotherapy?	0
Radiation toxicity grading after chemoradiotherapy of canine urinary tract carcinomas: Comparing VRTOG to VRTOG_v2.0	0
Adjuvant Chemotherapy Is Associated With Prolonged Survival Time in Small‐Breed Dogs Undergoing Amputation for Appendicular Osteosarcoma	0
Comparison of the anticancer effects of various statins on canine oral melanoma cells	0
Evaluation of the health‐related quality of life in dogs following intracranial meningioma resection using a specifically developed questionnaire	0
Canine lymphoma in 1914	0
Blood Neutrophil‐to‐Lymphocyte Ratio as a Potential Prognostic Marker in Dogs ≤10 kg With Multicentric Lymphoma	0
Early‐Delayed Radiotoxicity Associated With Stereotactic Radiation Therapy Following a Daily 6 Gy × 5 (30 Gy) Protocol for Presumed Canine Intracranial Meningiomas	0
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Difference in outcome between curative intent vs marginal excision as a first treatment in dogs with oral malignant melanoma and the impact of adjuvant CSPG4‐DNA electrovaccination: A retro	0
Outcomes and prognostic factors in canine epitheliotropic and nonepitheliotropic cutaneous T‐cell lymphomas	0
Expression of the hedgehog signalling pathway and the effect of inhibition at the level of smoothened in canine osteosarcoma cell lines	0
The second‐generation curcumin analogue RL71 elicits G2/M cell cycle arrest and apoptosis in canine osteosarcoma cells	0
Identification of genomic alterations with clinical impact in canine splenic hemangiosarcoma	0
DNA Methylation and Its Effects on TRIM29 Gene Expression in the Equine Sarcoid Tissue	0
Stereotactic radiotherapy outcomes for intraventricular brain tumours in 11 dogs	0
Statins downregulateYAPandTAZand exert anti‐cancer effects in canine mammary tumour cells	0
To map or not to map the cN0 neck: Impact of sentinel lymph node biopsy in canine head and neck tumours	0
Serum level of apoptosis inhibitor of macrophage in dogs with histiocytic sarcoma and its association with the disease	0