OOIR: Observatory of International Research

Papers

(The TQCC of Neoplasia is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Epitranscriptomic mechanisms of androgen signalling and prostate cancer	1574
ARID1A loss sensitizes colorectal cancer cells to floxuridine	110
Single cell analysis unveils the commonality and heterogeneity between nasopharyngeal and oropharyngeal carcinoma	91
Corrigendum to “Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells” [Neoplasia 17 (2014) 85]	54
Visualizing mast cell migration to tumor sites using sodium iodide symporter of nuclear medicine reporter gene	54
Corrigendum to “Tumorigenicity of IL-1α- and IL-1β-Deficient Fibrosarcoma Cells” [Neoplasia, Volume 10, Issue 6, June 2008, Pages 549–562]	51
Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis	47
DHX34 deficiency triggers tumor-intrinsic immunity via a dsRNA-mediated type I interferon pathway activation in HCC	41
L-methionine promotes CD8+ T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling	41
Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma	41
High metastatic tumor-derived CXCL16 mediates liver colonization metastasis by inducing Kupffer cell polarization via the PI3K/AKT/FOXO3a pathway	40
The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells	39
5-Aza-2′-deoxycytidin (Decitabine) increases cancer-testis antigen expression in head and neck squamous cell carcinoma and modifies immune checkpoint expression, especially in CD39-positive CD8 and CD	39
RUNX2 enhances bladder cancer progression by promoting glutamine metabolism	38
Combined radio-immunotherapy: An opportunity to increase the therapeutic ratio of oligometastasis-directed radiotherapy	37
Tumor-Infiltrating Immune Cells in Colorectal Cancer	36
Combination of sunitinib and 177Lu-labeled antibody cG250 targeted radioimmunotherapy: A promising new therapeutic strategy for patients with advanced renal cell cancer	36
Myxoid glioneuronal tumor: Histopathologic, neuroradiologic, and molecular features in a single center series	36
Role of heparanase 2 (Hpa2) in gastric cancer	33
Retraction notice to “Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors” [Neoplasia 18 (2016) 347- 355/201]	33
New horizons in B-cell lymphoma immunotherapy: From immune checkpoints to precision medicine	32
Mutational signatures and their association with survival and gene expression in urological carcinomas	31
From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy	31
Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice	30
Advanced progress of spatial metabolomics in head and neck cancer research	29

Leptomeningeal dissemination in pediatric brain tumors	29
Lactate promoted cisplatin resistance in NSCLC by modulating the m6A modification-mediated FOXO3/MAGI1-IT1/miR-664b-3p/IL-6R axis	28
Identification of recurrent BRAF non-V600 mutations in intraductal carcinoma of the prostate in Chinese populations	28
The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities	27
Epigenetic DNA modifications and vitamin C in prostate cancer and benign prostatic hyperplasia: Exploring similarities, disparities, and pathogenic implications	27
Colorectal cancer, Vitamin D and microbiota: A double-blind Phase II randomized trial (ColoViD) in colorectal cancer patients	27
Innate immunity: Looking beyond T-cells in radiation and immunotherapy combinations	26
Rezatapopt: A promising small-molecule “refolder” specific for TP53Y220C mutant tumors	25
STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications	25
Regulatory mechanisms of the Hippo/YAP axis by G-protein coupled estrogen receptor in gastric signet-ring cell carcinoma	24
Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis	23
Incidence, mortality, and global burden of retinoblastoma in 204 countries worldwide from 1990 to 2021: Data and systematic analysis from the Global Burden of Disease Study 2021	23
An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors	23
Longitudinal genomic alternations and clonal dynamics analysis of primary malignant melanoma of the esophagus	22
PDGF-BB overexpression in p53 null oligodendrocyte progenitors increases H3K27me3 and induces transcriptional changes which favor proliferation	22
Single-cell proteomic analysis reveals Multiple Myeloma heterogeneity and the dynamics of the tumor immune microenvironment in precursor and advanced states	22
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes	20
A novel regimen for pancreatic ductal adenocarcinoma targeting MEK, BCL-xL, and EGFR	20
Tumor-associated macrophages promote bladder cancer metastasis through the CCL20-CCR6 axis	20
Aurkin-A, a TPX2-Aurora A small molecule inhibitor disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma	20
Ovulation sources coagulation protease cascade and hepatocyte growth factor to support physiological growth and malignant transformation	20
A systematic review of microbiome-derived biomarkers for early colorectal cancer detection	19
β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis	19
Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats	18
Sustained experimental activation of FGF8/ERK in the developing chicken spinal cord models early events in ERK-mediated tumorigenesis	18
Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context	18
Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer	18
Corrigendum to “SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT Pathway” [Neoplasia (2021) 23, 1037–1047]	18
Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature	17
Acral melanoma: new insights into the immune and genomic landscape	17
Composition of gastrointestinal microbiota in association with treatment response in individuals with metastatic castrate resistant prostate cancer progressing on enzalutamide and initiating treatment	17
High dose acetaminophen re-polarizes CD11b+ cells in the tumor microenvironment towards an activated macrophage phenotype	17
Amelioration of muscle wasting by gintonin in cancer cachexia	17
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1)	17
HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma	17
The DNA mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression	16
Indigenous peoples and inclusion in clinical and genomic research: Understanding the history and navigating contemporary engagement	16
SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer	16
Pediatric neuro-oncology: Highlights of the last quarter-century	16
Circ_0089823 reinforces malignant behaviors of non-small cell lung cancer by acting as a sponge for microRNAs targeting SOX4,	16
Carcinogenesis induced by space radiation: A systematic review	15
Structure and function of the lysine methyltransferase SETD2 in cancer: From histones to cytoskeleton	15
Early separation and parallel clonal selection of dedifferentiated and well-differentiated components in dedifferentiated liposarcoma	15
Spatial profiling of METex14-altered NSCLC under tepotinib treatment: Shifting the immunosuppressive landscape	15
IGDQ motogenic peptide gradient induces directional cell migration through integrin (αv)β3 activation in MDA-MB-231 metastatic breast cancer cells	15
MYH knockdown in pancreatic cancer cells creates an exploitable DNA repair vulnerability	15
Targeting glycan sulfation in a CD11c+ myeloid population inhibits early KRAS-mutant lung neoplasia	15
Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma	15
A bioluminescence reporter mouse model for visualizing and quantifying CD8+ T cells in vivo	15
Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening	15

Whole-chromosome arm acquired uniparental disomy in cancer development is a consequence of isochromosome formation	15
BRAF p.V600E mutation as a molecular boundary between genuine oligo-repeated and poly-metastatic disease in colorectal cancer	14
Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor	14
Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5	13
Systemic inflammation in response to radiation drives the genesis of an immunosuppressed tumor microenvironment	13
Metformin use and survival in people with ovarian cancer: A population-based cohort study from British Columbia, Canada	13
Comparative effects of combustible cigarette versus electronic cigarette exposures on KRAS mutant lung cancer promotion	13
PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death	13
Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330]	13
Cell competition, cooperation, and cancer	13
High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer	13
PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome	13
Corrigendum to “NFAT1 hypermethylation promotes epithelial‐mesenchymal transition and metastasis in nasopharyngeal carcinoma by activating ITGA6 transcription” [Neoplasia 21 (2019): 311–321]	13
Bacterial translocation and barrier dysfunction enhance colonic tumorigenesis	12
Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents	12
Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances.	12
Therapeutic effiacy of T cells expressing chimeric antigen receptor derived from a mesothelin-specific scFv in orthotopic human pancreatic cancer animal models	12
Targeting myeloma metabolism: How abnormal metabolism contributes to multiple myeloma progression and resistance to proteasome inhibitors	12
Corrigendum to “Tumor Therapy Mediated by Lentiviral Expression of shBcl-2 and S-TRAIL” [Neoplasia. Vol. 9, No. 5, May 2007, pp. 435–442]	12
Current state of pediatric neuro-oncology imaging, challenges and future directions	12
Genomics driven precision oncology in advanced biliary tract cancer improves survival	12
Unveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression	12
Combining selinexor with alisertib to target the p53 pathway in neuroblastoma	12
mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics	11
CYP1B1 promotes angiogenesis and sunitinib resistance in clear cell renal cell carcinoma via USP5-mediated HIF2α deubiquitination	11
LncRNA HOTAIRM1 promotes radioresistance in nasopharyngeal carcinoma by modulating FTO acetylation-dependent alternative splicing of CD44	11
Corrigendum to “DNA-methylation eraser TET2 activates WTIP expression to suppress an AKT-dependent chemoresistance of gastric cancer” [Neoplasia volume 2025 Apr 24:65:101166]	11
DARPP-32 and t-DARPP in the development of resistance to anti-HER2 agents. Pre-clinical evidence from the STEP study	11
FAPα and αSMA mark different subsets of fibroblasts in normal kidney and conventional renal cell carcinoma	11
CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation	11
Regulation of prostate-specific membrane antigen (PSMA) expression in prostate cancer cells after treatment with dutasteride and lovastatin	11
Differential prognostic association of systemic inflammatory biomarkers on survival outcomes in head and neck squamous cell carcinoma patients by human papillomavirus status	11
Proteomic profiling of canine fibrosarcoma and adjacent peritumoral tissue	11
Spatial organization of heterogeneous immunotherapy target antigen expression in high-grade glioma	11
Phase I clinical trial of a novel procaspase-3 activator SM-1 with temozolomide in recurrent high-grade gliomas	11
Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells	11
The renal clear cell carcinoma immune landscape	10
Activation of PERK/eIF2α/ATF4 signaling inhibits ERα expression in breast cancer	10
Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer	10
Metformin combined with cisplatin reduces anticancer activity via ATM/CHK2-dependent upregulation of Rad51 pathway in ovarian cancer	10
Synergizing radiotherapy and immunotherapy: Current challenges and strategies for optimization	10
ΔNp63 silencing, DNA methylation shifts, and epithelial-mesenchymal transition resulted from TAp63 genome editing in squamous cell carcinoma	10
Furin, ADAM, and γ-secretase: Core regulatory targets in the Notch pathway and the therapeutic potential for breast cancer	10
RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells	10
Saturated fat exacerbates mitochondrial dysfunction through remodelling of ATP production and inflammation in Barrett’s oesophagus compared to monounsaturated fat, particularly in contrast to oesophag	10
Comprehensive profiling of EGFR mutation subtypes reveals genomic-clinical associations in non-small-cell lung cancer patients on first-generation EGFR inhibitors	10
Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition	10
Regulation of growth, invasion and metabolism of breast ductal carcinoma through CCL2/CCR2 signaling interactions with MET receptor tyrosine kinases	10
AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling	10
Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma	10