OOIR: Observatory of International Research

Papers

(The TQCC of Neoplasia is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Epitranscriptomic mechanisms of androgen signalling and prostate cancer	1387
ARID1A loss sensitizes colorectal cancer cells to floxuridine	105
Single cell analysis unveils the commonality and heterogeneity between nasopharyngeal and oropharyngeal carcinoma	81
Visualizing mast cell migration to tumor sites using sodium iodide symporter of nuclear medicine reporter gene	69
Corrigendum to “Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells” [Neoplasia 17 (2014) 85]	60
Corrigendum to “Tumorigenicity of IL-1α- and IL-1β-Deficient Fibrosarcoma Cells” [Neoplasia, Volume 10, Issue 6, June 2008, Pages 549–562]	49
Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis	47
L-methionine promotes CD8+ T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling	44
Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma	40
The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells	39
5-Aza-2′-deoxycytidin (Decitabine) increases cancer-testis antigen expression in head and neck squamous cell carcinoma and modifies immune checkpoint expression, especially in CD39-positive CD8 and CD	39
RUNX2 enhances bladder cancer progression by promoting glutamine metabolism	38
Tumor-Infiltrating Immune Cells in Colorectal Cancer	36
Role of heparanase 2 (Hpa2) in gastric cancer	35
Combined radio-immunotherapy: An opportunity to increase the therapeutic ratio of oligometastasis-directed radiotherapy	34
Retraction notice to “Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors” [Neoplasia 18 (2016) 347- 355/201]	34
Myxoid glioneuronal tumor: Histopathologic, neuroradiologic, and molecular features in a single center series	34
Combination of sunitinib and 177Lu-labeled antibody cG250 targeted radioimmunotherapy: A promising new therapeutic strategy for patients with advanced renal cell cancer	33
Mutational signatures and their association with survival and gene expression in urological carcinomas	33
Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice	32
From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy	32
Colorectal cancer, Vitamin D and microbiota: A double-blind Phase II randomized trial (ColoViD) in colorectal cancer patients	30
Advanced progress of spatial metabolomics in head and neck cancer research	30
The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities	29
Identification of recurrent BRAF non-V600 mutations in intraductal carcinoma of the prostate in Chinese populations	29

Epigenetic DNA modifications and vitamin C in prostate cancer and benign prostatic hyperplasia: Exploring similarities, disparities, and pathogenic implications	28
Lactate promoted cisplatin resistance in NSCLC by modulating the m6A modification-mediated FOXO3/MAGI1-IT1/miR-664b-3p/IL-6R axis	28
Innate immunity: Looking beyond T-cells in radiation and immunotherapy combinations	28
Leptomeningeal dissemination in pediatric brain tumors	27
STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications	27
Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis	26
Incidence, mortality, and global burden of retinoblastoma in 204 countries worldwide from 1990 to 2021: Data and systematic analysis from the Global Burden of Disease Study 2021	26
Aurkin-A, a TPX2-Aurora A small molecule inhibitor disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma	25
An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors	25
Tumor-associated macrophages promote bladder cancer metastasis through the CCL20-CCR6 axis	25
A novel regimen for pancreatic ductal adenocarcinoma targeting MEK, BCL-xL, and EGFR	24
Molecular subtypes based on CNVs related gene signatures identify candidate prognostic biomarkers in lung adenocarcinoma	23
PDGF-BB overexpression in p53 null oligodendrocyte progenitors increases H3K27me3 and induces transcriptional changes which favor proliferation	23
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes	23
β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis	22
Ovulation sources coagulation protease cascade and hepatocyte growth factor to support physiological growth and malignant transformation	21
A systematic review of microbiome-derived biomarkers for early colorectal cancer detection	21
Longitudinal genomic alternations and clonal dynamics analysis of primary malignant melanoma of the esophagus	21
MET inhibition downregulates DR4 expression in MET-amplified lung cancer cells with acquired resistance to EGFR inhibitors through suppressing AP-1-mediated transcription	20
Corrigendum to “SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT Pathway” [Neoplasia (2021) 23, 1037–1047]	20
Circ_0089823 reinforces malignant behaviors of non-small cell lung cancer by acting as a sponge for microRNAs targeting SOX4,	20
Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context	19
Pediatric neuro-oncology: Highlights of the last quarter-century	19
Amelioration of muscle wasting by gintonin in cancer cachexia	18
Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer	18
High dose acetaminophen re-polarizes CD11b+ cells in the tumor microenvironment towards an activated macrophage phenotype	18
Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats	18
SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer	18
Acral melanoma: new insights into the immune and genomic landscape	17
Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature	17
HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma	17
Sustained experimental activation of FGF8/ERK in the developing chicken spinal cord models early events in ERK-mediated tumorigenesis	17
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1)	17
Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening	16
Composition of gastrointestinal microbiota in association with treatment response in individuals with metastatic castrate resistant prostate cancer progressing on enzalutamide and initiating treatment	16
MYH knockdown in pancreatic cancer cells creates an exploitable DNA repair vulnerability	16
Early separation and parallel clonal selection of dedifferentiated and well-differentiated components in dedifferentiated liposarcoma	16
Indigenous peoples and inclusion in clinical and genomic research: Understanding the history and navigating contemporary engagement	16
Cell competition, cooperation, and cancer	15
miR-138-5p induces aggressive traits by targeting Trp53 expression in murine melanoma cells, and correlates with poor prognosis of melanoma patients	15
Targeting glycan sulfation in a CD11c+ myeloid population inhibits early KRAS-mutant lung neoplasia	15
High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer	15
Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor	15
Spatial profiling of METex14-altered NSCLC under tepotinib treatment: Shifting the immunosuppressive landscape	15
PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome	15
Whole-chromosome arm acquired uniparental disomy in cancer development is a consequence of isochromosome formation	14
A bioluminescence reporter mouse model for visualizing and quantifying CD8+ T cells in vivo	14
Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma	14
Unveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression	14
Carcinogenesis induced by space radiation: A systematic review	14

BRAF p.V600E mutation as a molecular boundary between genuine oligo-repeated and poly-metastatic disease in colorectal cancer	14
Structure and function of the lysine methyltransferase SETD2 in cancer: From histones to cytoskeleton	14
Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330]	14
IGDQ motogenic peptide gradient induces directional cell migration through integrin (αv)β3 activation in MDA-MB-231 metastatic breast cancer cells	14
PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death	14
Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5	14
Corrigendum to “NFAT1 hypermethylation promotes epithelial‐mesenchymal transition and metastasis in nasopharyngeal carcinoma by activating ITGA6 transcription” [Neoplasia 21 (2019): 311–321]	13
Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances.	13
Systemic inflammation in response to radiation drives the genesis of an immunosuppressed tumor microenvironment	13
Corrigendum to “Tumor Therapy Mediated by Lentiviral Expression of shBcl-2 and S-TRAIL” [Neoplasia. Vol. 9, No. 5, May 2007, pp. 435–442]	12
Metformin use and survival in people with ovarian cancer: A population-based cohort study from British Columbia, Canada	12
Therapeutic effiacy of T cells expressing chimeric antigen receptor derived from a mesothelin-specific scFv in orthotopic human pancreatic cancer animal models	12
Targeting myeloma metabolism: How abnormal metabolism contributes to multiple myeloma progression and resistance to proteasome inhibitors	12
CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation	12
Combining selinexor with alisertib to target the p53 pathway in neuroblastoma	12
mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer	12
Current state of pediatric neuro-oncology imaging, challenges and future directions	12
FAPα and αSMA mark different subsets of fibroblasts in normal kidney and conventional renal cell carcinoma	12
Bacterial translocation and barrier dysfunction enhance colonic tumorigenesis	12
Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents	12
Genomics driven precision oncology in advanced biliary tract cancer improves survival	12
Spatial organization of heterogeneous immunotherapy target antigen expression in high-grade glioma	11
Reduction in mitochondrial oxidative stress mediates hypoxia-induced resistance to cisplatin in human transitional cell carcinoma cells	11
Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells	11
mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics	11
LncRNA HOTAIRM1 promotes radioresistance in nasopharyngeal carcinoma by modulating FTO acetylation-dependent alternative splicing of CD44	11
DARPP-32 and t-DARPP in the development of resistance to anti-HER2 agents. Pre-clinical evidence from the STEP study	11
Proteomic profiling of canine fibrosarcoma and adjacent peritumoral tissue	11
Synergizing radiotherapy and immunotherapy: Current challenges and strategies for optimization	11
Regulation of prostate-specific membrane antigen (PSMA) expression in prostate cancer cells after treatment with dutasteride and lovastatin	11
Metformin combined with cisplatin reduces anticancer activity via ATM/CHK2-dependent upregulation of Rad51 pathway in ovarian cancer	10
AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling	10
Copy number variation in triple negative breast cancer samples associated with lymph node metastasis	10
Furin, ADAM, and γ-secretase: Core regulatory targets in the Notch pathway and the therapeutic potential for breast cancer	10
The kinetics of blast clearance are associated with copy number alterations in childhood B-cell acute lymphoblastic leukemia	10
Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition	10
Naproxen inhibits spontaneous lung adenocarcinoma formation in KrasG12V mice	10
Spatial distribution of immune checkpoint proteins in histological subtypes of lung adenocarcinoma	10
Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer	10
Maestros of malignancy: Microbes as the conductors of carcinogenesis	10
Phase I clinical trial of a novel procaspase-3 activator SM-1 with temozolomide in recurrent high-grade gliomas	10
Regulation of growth, invasion and metabolism of breast ductal carcinoma through CCL2/CCR2 signaling interactions with MET receptor tyrosine kinases	10
ΔNp63 silencing, DNA methylation shifts, and epithelial-mesenchymal transition resulted from TAp63 genome editing in squamous cell carcinoma	10
Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma	10
RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells	10
Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model	10
Comprehensive profiling of EGFR mutation subtypes reveals genomic-clinical associations in non-small-cell lung cancer patients on first-generation EGFR inhibitors	10
The renal clear cell carcinoma immune landscape	10