Molecular Cancer

(The TQCC of Molecular Cancer is 55. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-01-01 to 2024-01-01.)
Autophagy and autophagy-related proteins in cancer665
m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer595
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives568
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer472
The potential role of RNA N6-methyladenosine in Cancer progression456
Circular RNA: metabolism, functions and interactions with proteins434
mRNA vaccine for cancer immunotherapy387
Translation and functional roles of circular RNAs in human cancer372
Targeting STAT3 in Cancer Immunotherapy370
The cancer metabolic reprogramming and immune response319
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects314
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions311
Natural killer cells in cancer biology and therapy302
Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA295
METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST293
Ferroptosis in cancer therapy: a novel approach to reversing drug resistance268
RETRACTED ARTICLE: LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis266
The role of long noncoding RNAs in hepatocellular carcinoma266
Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma258
Noncoding RNAs in gastric cancer: implications for drug resistance232
Glioma targeted therapy: insight into future of molecular approaches225
Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy225
The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer223
Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis219
G-quadruplexes: a promising target for cancer therapy216
PARP inhibitor resistance: the underlying mechanisms and clinical implications211
m6A-dependent glycolysis enhances colorectal cancer progression210
Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation210
The significance of exosomes in the development and treatment of hepatocellular carcinoma209
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner206
Exosome-based immunotherapy: a promising approach for cancer treatment205
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes205
Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy205
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities204
Exosomes as a new frontier of cancer liquid biopsy194
Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications192
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities188
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling188
CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis180
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC177
The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis174
CircRNA inhibits DNA damage repair by interacting with host gene174
Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc174
Targeting TGF-β signal transduction for fibrosis and cancer therapy172
lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling171
Wnt signaling in colorectal cancer: pathogenic role and therapeutic target169
Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments169
Metabolism of pancreatic cancer: paving the way to better anticancer strategies168
The role of ubiquitination and deubiquitination in cancer metabolism168
The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression167
METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer165
Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance165
mRNA vaccine: a potential therapeutic strategy162
Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies158
Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells157
Mechanism of RNA modification N6-methyladenosine in human cancer156
Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy153
The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs152
The role of m6A RNA methylation in cancer metabolism152
Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine150
Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments149
Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer147
mRNA therapeutics in cancer immunotherapy146
N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling146
ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1144
Long noncoding RNAs: functions and mechanisms in colon cancer141
Novel insights into the interplay between m6A modification and noncoding RNAs in cancer138
DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma137
YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer134
PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications133
Role of non-coding RNAs and RNA modifiers in cancer therapy resistance132
CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer128
N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer128
Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook126
A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer126
RETRACTED ARTICLE: Exosome-mediated lncRNA AFAP1-AS1 promotes trastuzumab resistance through binding with AUF1 and activating ERBB2 translation126
circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2124
Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression124
Roles of circRNAs in the tumour microenvironment123
Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis123
Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer121
Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer119
Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology119
Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340118
Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer115
Functions and clinical significance of circular RNAs in glioma115
Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression114
Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance114
Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1113
METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer113
m6A modification: recent advances, anticancer targeted drug discovery and beyond111
Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation108
Role of HDACs in normal and malignant hematopoiesis108
Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis105
The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation105
Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma104
Long non-coding RNAs regulate drug resistance in cancer101
Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy100
circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer98
circRIP2 accelerates bladder cancer progression via miR-1305/Tgf-β2/smad3 pathway98
CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification97
cGAS-STING pathway in cancer biotherapy96
RETRACTED ARTICLE: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p96
A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling95
CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc94
Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring93
Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit93
EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP392
Cancer associated-fibroblast-derived exosomes in cancer progression90
Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis90
LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM89
Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis88
Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer86
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer85
Epigenetic modulation of antitumor immunity for improved cancer immunotherapy85
Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p/CXCL12 axis in melanoma85
CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-1785
Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab85
CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a84
Identification of tumor antigens and immune subtypes of pancreatic adenocarcinoma for mRNA vaccine development84
Clinical and immunological effects of mRNA vaccines in malignant diseases84
Long non-coding RNA UCA1 promotes malignant phenotypes of renal cancer cells by modulating the miR-182-5p/DLL4 axis as a ceRNA82
LINC00173.v1 promotes angiogenesis and progression of lung squamous cell carcinoma by sponging miR-511-5p to regulate VEGFA expression82
Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response82
circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway81
Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis81
Non-coding RNAs regulation of macrophage polarization in cancer79
Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer79
Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis79
DDX3X: structure, physiologic functions and cancer79
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas78
Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer76
Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC76
TEAD4 modulated LncRNA MNX1-AS1 contributes to gastric cancer progression partly through suppressing BTG2 and activating BCL276
Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance75
Proteolysis-targeting chimeras (PROTACs) in cancer therapy74
CircRNAs: biogenesis, functions, and role in drug-resistant Tumours73
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review71
Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer71
CircPTPRA blocks the recognition of RNA N6-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression70
Circulating tumor cells in cancer patients: developments and clinical applications for immunotherapy70
The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy70
Identification of tumor antigens and immune subtypes of cholangiocarcinoma for mRNA vaccine development70
The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy68
The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer68
Cuproptosis: mechanisms and links with cancers67
Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2′-O-methylation via NOP58 recruitment in colorectal cancer67
Tumor-associated exosomes promote lung cancer metastasis through multiple mechanisms67
Current applications and future perspective of CRISPR/Cas9 gene editing in cancer66
The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway66
The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition66
Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications65
CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing65
The emerging role of SPOP protein in tumorigenesis and cancer therapy65
Targeting the RNA m6A modification for cancer immunotherapy65
METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis65
Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma64
Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy64
Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3–eIF3h interaction64
Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX264
Insights into N6-methyladenosine and programmed cell death in cancer64
Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology64
Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness64
CircRNAs in anticancer drug resistance: recent advances and future potential63
Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing63
Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy63
A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study63
Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer63
The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis63
Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis62
Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin62
CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability62
Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell?62
Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer61
CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway61
MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer61
Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection60
Lung cancer immunotherapy: progress, pitfalls, and promises60
Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification60
ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma59
Crosstalk between autophagy and metabolic regulation of cancer stem cells59
FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF259
Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme58
CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer58
β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer58
The predicting role of circulating tumor DNA landscape in gastric cancer patients treated with immune checkpoint inhibitors57
Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer57
Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy57
Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression57
M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma56
Noncoding RNAs in cancer immunity: functions, regulatory mechanisms, and clinical application56
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance56
Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer56
m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling56
Epigenetic silencing of miR-144/451a cluster contributes to HCC progression via paracrine HGF/MIF-mediated TAM remodeling56
RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment55
circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis55
lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer55
Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications55
Targeting the tumor stroma for cancer therapy55