Molecular Cancer

Article	Citations
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives	692
Circular RNA: metabolism, functions and interactions with proteins	522
The potential role of RNA N6-methyladenosine in Cancer progression	496
mRNA vaccine for cancer immunotherapy	443
Targeting STAT3 in Cancer Immunotherapy	416
Combination strategies with PD-1/PD-L1 blockade: current advances and future directions	398
The cancer metabolic reprogramming and immune response	380
Ferroptosis in cancer therapy: a novel approach to reversing drug resistance	356
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects	353
Natural killer cells in cancer biology and therapy	331
The role of long noncoding RNAs in hepatocellular carcinoma	293
Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma	279
RETRACTED ARTICLE: LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis	277
Glioma targeted therapy: insight into future of molecular approaches	275
Exosomes as a new frontier of cancer liquid biopsy	249
Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis	248
Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy	246
The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer	242
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities	240
Exosome-based immunotherapy: a promising approach for cancer treatment	239
G-quadruplexes: a promising target for cancer therapy	238
Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy	237
Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation	235
m6A-dependent glycolysis enhances colorectal cancer progression	234
Targeting TGF-β signal transduction for fibrosis and cancer therapy	231

PARP inhibitor resistance: the underlying mechanisms and clinical implications	228
Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments	226
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes	224
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner	221
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities	213
Wnt signaling in colorectal cancer: pathogenic role and therapeutic target	213
The role of m6A RNA methylation in cancer metabolism	196
CircRNA inhibits DNA damage repair by interacting with host gene	194
The role of ubiquitination and deubiquitination in cancer metabolism	191
Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc	186
mRNA vaccine: a potential therapeutic strategy	182
METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer	179
Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance	178
Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments	172
Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies	172
The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs	170
Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells	168
Mechanism of RNA modification N6-methyladenosine in human cancer	168
Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine	164
mRNA therapeutics in cancer immunotherapy	164
N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling	163
Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer	159
ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1	158
Long noncoding RNAs: functions and mechanisms in colon cancer	155
N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer	147
YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer	146
Novel insights into the interplay between m6A modification and noncoding RNAs in cancer	143
m6A modification: recent advances, anticancer targeted drug discovery and beyond	138
Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook	136
Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer	135
Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer	134
A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer	134
Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis	132
Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer	132
circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2	128
METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer	127
Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation	127
Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology	126
cGAS-STING pathway in cancer biotherapy	121
Cancer associated-fibroblast-derived exosomes in cancer progression	120
Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression	119
A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling	118
EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3	117
The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation	117
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer	116
Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring	115
Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer	114
Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy	114
Cuproptosis: mechanisms and links with cancers	113
Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis	111

Lung cancer immunotherapy: progress, pitfalls, and promises	110
Epigenetic modulation of antitumor immunity for improved cancer immunotherapy	105
CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc	104
circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer	103
Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit	103
Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer	99
RETRACTED ARTICLE: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p	98
Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis	98
Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis	96
LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM	94
DDX3X: structure, physiologic functions and cancer	93
Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p/CXCL12 axis in melanoma	93
Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC	93
Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab	91
Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing	91
Identification of tumor antigens and immune subtypes of pancreatic adenocarcinoma for mRNA vaccine development	90
Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy	89
Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer	89
Proteolysis-targeting chimeras (PROTACs) in cancer therapy	88
Clinical and immunological effects of mRNA vaccines in malignant diseases	87
Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer	87
LINC00173.v1 promotes angiogenesis and progression of lung squamous cell carcinoma by sponging miR-511-5p to regulate VEGFA expression	87
Current applications and future perspective of CRISPR/Cas9 gene editing in cancer	86
Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis	84
Non-coding RNAs regulation of macrophage polarization in cancer	84
circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway	84
Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis	84
The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition	81
Identification of tumor antigens and immune subtypes of cholangiocarcinoma for mRNA vaccine development	80
Insights into N6-methyladenosine and programmed cell death in cancer	79
CircPTPRA blocks the recognition of RNA N6-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression	79
METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis	79
Targeting the RNA m6A modification for cancer immunotherapy	79
Tumor-associated exosomes promote lung cancer metastasis through multiple mechanisms	78
The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy	78
The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy	77
CircRNAs: biogenesis, functions, and role in drug-resistant Tumours	76
The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway	76
A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study	74
Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer	74
Targeting the tumor stroma for cancer therapy	74
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments	73
M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma	73
Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3–eIF3h interaction	73
Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin	73
Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification	72
Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy	72
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review	71
Proteomics technologies for cancer liquid biopsies	71
Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2′-O-methylation via NOP58 recruitment in colorectal cancer	71
Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma	69
Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell?	69
CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability	69
Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications	69
Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis	69
CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances	69
CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing	68
Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression	68
CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway	68
CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer	67
The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis	66
FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2	65
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling	65
Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer	64
ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma	64
Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications	64
Advancements in nanoparticle-based treatment approaches for skin cancer therapy	64
CircRNAs in anticancer drug resistance: recent advances and future potential	64
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer	64
A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression	64
Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection	62
Epigenetic silencing of miR-144/451a cluster contributes to HCC progression via paracrine HGF/MIF-mediated TAM remodeling	62
Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer	62
Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential	61
Plasma-derived exosomal miR-15a-5p as a promising diagnostic biomarker for early detection of endometrial carcinoma	61
A novel peptide encoded by N6-methyladenosine modified circMAP3K4 prevents apoptosis in hepatocellular carcinoma	61
The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p	61
β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer	61
Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types	61
The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies	60

Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy	60
The predicting role of circulating tumor DNA landscape in gastric cancer patients treated with immune checkpoint inhibitors	60
RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment	60
Delivery of cancer therapies by synthetic and bio-inspired nanovectors	59
circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis	59
Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2	59
m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling	59
Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p	59
Targeting KRAS mutant cancers: from druggable therapy to drug resistance	58
Liquid biopsy for therapy monitoring in early-stage non-small cell lung cancer	56
Histone citrullination: a new target for tumors	55
LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer	55
Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions	55
Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma	55
CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer	54
The PVT1 lncRNA is a novel epigenetic enhancer of MYC, and a promising risk-stratification biomarker in colorectal cancer	54
Chemotherapeutic and targeted agents can modulate the tumor microenvironment and increase the efficacy of immune checkpoint blockades	53
Potential clinical utility of liquid biopsies in ovarian cancer	53
CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma	53
LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer	53
LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway	53
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma	51
The role and application of small extracellular vesicles in gastric cancer	51
Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy	51
Identification of a distinct luminal subgroup diagnosing and stratifying early stage prostate cancer by tissue-based single-cell RNA sequencing	51
The potential roles of exosomes in pancreatic cancer initiation and metastasis	51
Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer	51
The involvement of exosomes in the diagnosis and treatment of pancreatic cancer	51
RNA-based therapies: A cog in the wheel of lung cancer defense	50
A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3	50
Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis	49
A novel class of tsRNA signatures as biomarkers for diagnosis and prognosis of pancreatic cancer	49
Circular RNAs’ cap-independent translation protein and its roles in carcinomas	49
Clinical significance of FBXW7 loss of function in human cancers	48
Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-κB/bone remodeling factors signaling	47
The circROBO1/KLF5/FUS feedback loop regulates the liver metastasis of breast cancer by inhibiting the selective autophagy of afadin	47
Unraveling tumour microenvironment heterogeneity in nasopharyngeal carcinoma identifies biologically distinct immune subtypes predicting prognosis and immunotherapy responses	47
CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner	47
CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502–5p/KRAS and IGF2BP2/Myc axes	47
Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA	47
circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling	47
CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p	47
Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy	47
mRNA in cancer immunotherapy: beyond a source of antigen	47
The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC	47