OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Cancer is 110. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Correction to: The function and mechanisms of action of circular RNAs in Urologic Cancer	1376
LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer	1072
Spatial and functional dissection of cancer-associated fibroblasts-mediated immune modulation in H. pylori-associated gastric cancer	1060
Development and validation of a small extracellular vesicle-derived RNA signature for early diagnosis of lung adenocarcinoma and prognosis in advanced stages	823
BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer	788
Immunotherapies in rare cancers	786
CRISPR based therapeutics: a new paradigm in cancer precision medicine	676
Chaperone-mediated autophagy modulates Snail protein stability: implications for breast cancer metastasis	664
Correction: m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC	649
Neoadjuvant immunotherapy in squamous cell carcinoma of the head and neck: current evidence and future perspectives	638
The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis	626
The CD47/TSP-1 axis: a promising avenue for ovarian cancer treatment and biomarker research	575
E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer	563
Proteogenomic characterization of molecular and cellular targets for treatment-resistant subtypes in locally advanced cervical cancers	495
The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments	447
Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells	415
Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma	413
TGF-β signaling promotes cervical cancer metastasis via CDR1as	349
Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma	343
Engineered multifunctional nanoparticles for enhanced radiation therapy: three-in-one approach for cancer treatment	331
STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway	327
Advances in RNA-based cancer therapeutics: pre-clinical and clinical implications	319
Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers	304
The miR-23a/27a/24 − 2 cluster drives immune evasion and resistance to PD-1/PD-L1 blockade in non-small cell lung cancer	302
The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers	288

circNOX4 activates an inflammatory fibroblast niche to promote tumor growth and metastasis in NSCLC via FAP/IL-6 axis	276
Genome-wide CRISPR screening identifies tyrosylprotein sulfotransferase-2 as a target for augmenting anti-PD1 efficacy	273
LINC02159 promotes non-small cell lung cancer progression via ALYREF/YAP1 signaling	262
JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression	255
ERK mediates interferon gamma-induced melanoma cell death	254
EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3	248
Traditional Chinese medicine for the treatment of cancers of hepatobiliary system: from clinical evidence to drug discovery	246
Exosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancer	240
Correction: Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis	239
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state	234
Efferocytosis: the art of cellular clearance and novel perspectives in disease therapy	216
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis	212
Myofibroblast-derived extracellular vesicles facilitate cancer stemness of hepatocellular carcinoma via transferring ITGA5 to tumor cells	210
PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN	205
LINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling	202
Correction: YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment	201
Biomolecular phase separation in tumorigenesis: from aberrant condensates to therapeutic vulnerabilities	198
Increased plasma concentrations of acyl-coenzyme A binding protein (ACBP) predict future lung cancer development in smokers at risk of cardiovascular disease	192
Biofilm formation by the host microbiota: a protective shield against immunity and its implication in cancer	191
Nuclear receptors as novel regulators that modulate cancer radiosensitivity and normal tissue radiotoxicity	190
Emerging roles of tRNA-derived fragments in cancer	177
Bidirectional role of neutrophils in tumor development	177
Effects of RNA methylation on Tumor angiogenesis and cancer progression	175
Nanotechnology-leveraged CRISPR/Cas systems: icebreaking in trace cancer-related nucleic acids biosensing	174
Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer	172
Letter to the Editor: An ultra-sensitive assay using cell-free DNA fragmentomics for multi-cancer early detection	171
Gold nanoparticles and gold nanorods in the landscape of cancer therapy	170
Nasopharyngeal carcinoma: current views on the tumor microenvironment's impact on drug resistance and clinical outcomes	170
NK cells are never alone: crosstalk and communication in tumour microenvironments	167
Tumor cell-intrinsic MELK enhanced CCL2-dependent immunosuppression to exacerbate hepatocarcinogenesis and confer resistance of HCC to radiotherapy	166
Nanomedicine in Cancer Therapeutics: Current Perspectives from Bench to Bedside	164
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments	163
Insights into N6-methyladenosine and programmed cell death in cancer	162
Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation	162
Dissecting small cell carcinoma of the esophagus ecosystem by single-cell transcriptomic analysis	161
Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer	161
Correction: CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling	156
Retraction Note: Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis	156
The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer	155
Tumor-associated macrophages: untapped molecular targets to improve T cell-based immunotherapy	155
Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance	153
lncRNAs: the unexpected link between protein synthesis and cancer adaptation	150
A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer	150
Circular RNA circCLASP2 promotes nasopharyngeal carcinoma progression through binding to DHX9 to enhance PCMT1 translation	148
CircAKT3 promotes prostate cancer proliferation and metastasis by enhancing the binding of RPS27A and RPL11	147
Enhancing therapeutic anti-cancer responses by combining immune checkpoint and tyrosine kinase inhibition	147
Biologically targeted dual adaptive and innate nano-Immunotherapy for clear cell renal cell carcinoma treatment	146
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy	143
Correction: Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis	141
Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies	140

Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors	138
Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells	137
The application of organoids in treatment decision-making for digestive system cancers: progress and challenges	137
Targeting HNRNPU to overcome cisplatin resistance in bladder cancer	137
m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma	135
Loss of TACC2 impairs chemokine CCL3 and CCL4 expression and reduces response to anti-PD-1 therapy in soft tissue sarcoma	134
DLL3-guided therapies in small-cell lung cancer: from antibody-drug conjugate to precision immunotherapy and radioimmunotherapy	133
Correction: Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1	133
Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer	128
Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing	127
Molecular mechanisms of tumor resistance to radiotherapy	127
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment	127
Context-dependent impact of type I interferon signaling in cancer	125
Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression	124
Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring	124
A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression	123
EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?	122
Activation-induced cytidine deaminase causes recurrent splicing mutations in diffuse large B-cell lymphoma	122
Correction: MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer	122
Deciphering a profiling based on multiple post-translational modifications functionally associated regulatory patterns and therapeutic opportunities in human hepatocellular carcinoma	121
Multifaceted roles for BCL3 in cancer: a proto-oncogene comes of age	120
Targeting metastasis in paediatric bone sarcomas	120
Size matters: integrating tumour volume and immune activation signatures predicts immunotherapy response	118
N-glycosylation of PD-L1 modulates the efficacy of immune checkpoint blockades targeting PD-L1 and PD-1	118
A PIK3CA-mutant breast cancer metastatic patient-derived organoid approach to evaluate alpelisib treatment for multiple secondary lesions	116
CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma	116
Distinct pattern of genomic breakpoints in CML and BCR::ABL1-positive ALL: analysis of 971 patients	115
Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies	115
CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling	114
Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer	113
Unveiling the PDK4-centered rituximab-resistant mechanism in DLBCL: the potential of the “Smart” exosome nanoparticle therapy	112
A positive feedback circuit driven by m6A-modified circular RNA facilitates colorectal cancer liver metastasis	112
Multimodal sequencing of neoadjuvant nivolumab treatment in hepatocellular carcinoma reveals cellular and molecular immune landscape for drug response	112
An exosome-based liquid biopsy signature for pre-operative identification of lymph node metastasis in patients with pathological high-risk T1 colorectal cancer	111
Deciphering the tumor immune microenvironment from a multidimensional omics perspective: insight into next-generation CAR-T cell immunotherapy and beyond	110
Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy	110
Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway	110