OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Cancer is 90. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Genome-wide CRISPR screening identifies tyrosylprotein sulfotransferase-2 as a target for augmenting anti-PD1 efficacy	1317
The miR-23a/27a/24 − 2 cluster drives immune evasion and resistance to PD-1/PD-L1 blockade in non-small cell lung cancer	811
Correction: m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC	759
Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells	734
Using single-cell sequencing technology to detect circulating tumor cells in solid tumors	557
Engineered multifunctional nanoparticles for enhanced radiation therapy: three-in-one approach for cancer treatment	509
Proteogenomic characterization of molecular and cellular targets for treatment-resistant subtypes in locally advanced cervical cancers	504
The CD47/TSP-1 axis: a promising avenue for ovarian cancer treatment and biomarker research	480
TGF-β signaling promotes cervical cancer metastasis via CDR1as	462
STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway	449
Immunotherapies in rare cancers	447
JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression	435
Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers	381
Correction to: The function and mechanisms of action of circular RNAs in Urologic Cancer	365
Chaperone-mediated autophagy modulates Snail protein stability: implications for breast cancer metastasis	334
Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6	292
CRISPR based therapeutics: a new paradigm in cancer precision medicine	259
The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis	256
circNOX4 activates an inflammatory fibroblast niche to promote tumor growth and metastasis in NSCLC via FAP/IL-6 axis	253
Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma	250
E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer	247
The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments	241
Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma	241
Traditional Chinese medicine for the treatment of cancers of hepatobiliary system: from clinical evidence to drug discovery	232
LINC02159 promotes non-small cell lung cancer progression via ALYREF/YAP1 signaling	231

The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers	211
Exosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancer	205
EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3	194
ERK mediates interferon gamma-induced melanoma cell death	193
The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC	186
Correction: YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment	175
Myofibroblast-derived extracellular vesicles facilitate cancer stemness of hepatocellular carcinoma via transferring ITGA5 to tumor cells	173
Letter to the Editor: An ultra-sensitive assay using cell-free DNA fragmentomics for multi-cancer early detection	171
Effects of RNA methylation on Tumor angiogenesis and cancer progression	169
Tumor cell-intrinsic MELK enhanced CCL2-dependent immunosuppression to exacerbate hepatocarcinogenesis and confer resistance of HCC to radiotherapy	168
Correction to: The lncRNA UCA1 promotes proliferation, migration, immune escape and inhibits apoptosis in gastric cancer by sponging anti-tumor miRNAs	162
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state	160
Nanotechnology-leveraged CRISPR/Cas systems: icebreaking in trace cancer-related nucleic acids biosensing	153
Correction: Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis	153
Bidirectional role of neutrophils in tumor development	151
Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer	149
Nasopharyngeal carcinoma: current views on the tumor microenvironment's impact on drug resistance and clinical outcomes	146
NK cells are never alone: crosstalk and communication in tumour microenvironments	146
Insights into N6-methyladenosine and programmed cell death in cancer	144
LINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling	138
PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN	136
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments	135
Emerging roles of tRNA-derived fragments in cancer	135
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis	132
Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation	130
Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer	130
Gold nanoparticles and gold nanorods in the landscape of cancer therapy	128
GM-CSF mediates immune evasion via upregulation of PD-L1 expression in extranodal natural killer/T cell lymphoma	127
An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks	127
A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer	126
A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression	123
m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma	123
Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells	123
The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer	120
Enhancing therapeutic anti-cancer responses by combining immune checkpoint and tyrosine kinase inhibition	119
Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors	116
EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?	115
Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer	114
DLL3-guided therapies in small-cell lung cancer: from antibody-drug conjugate to precision immunotherapy and radioimmunotherapy	114
Crosstalk between autophagy and microbiota in cancer progression	114
Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma	112
Correction: Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1	111
lncRNAs: the unexpected link between protein synthesis and cancer adaptation	111
CircAKT3 promotes prostate cancer proliferation and metastasis by enhancing the binding of RPS27A and RPL11	109
Correction: CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling	108
Circular RNA circCLASP2 promotes nasopharyngeal carcinoma progression through binding to DHX9 to enhance PCMT1 translation	108
Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance	106
Retraction Note: Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis	105
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy	104
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment	103

Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression	103
Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring	100
Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies	99
Targeting HNRNPU to overcome cisplatin resistance in bladder cancer	98
Molecular mechanisms of tumor resistance to radiotherapy	98
Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-catenin	98
N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer	96
Correction: MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer	95
Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing	95
Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies	95
BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors	92
Size matters: integrating tumour volume and immune activation signatures predicts immunotherapy response	92
Correction to: Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma	92
Distinct pattern of genomic breakpoints in CML and BCR::ABL1-positive ALL: analysis of 971 patients	91
Correction: Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy	90
Activation-induced cytidine deaminase causes recurrent splicing mutations in diffuse large B-cell lymphoma	90