OOIR: Observatory of International Research

Papers

(The TQCC of Aging Cell is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice	220
Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo	137
A genome‐wide association study of the frailty index highlights brain pathways in ageing	127
Epigenetic age prediction	102
mTORC2: The other mTOR in autophagy regulation	101
On the evolution of cellular senescence	98
Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans	91
Necroptosis contributes to chronic inflammation and fibrosis in aging liver	88
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study	88
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity	86
Mitochondrial DNA in extracellular vesicles declines with age	85
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes	84
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus	80
Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging	79
BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy	77
Proteomics in aging research: A roadmap to clinical, translational research	77
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming	75
Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus	73
NAD⁺ supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy	67
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age	66
Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells	65
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis	64
Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation	64
α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease	63
17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex	63

Genetic associations for two biological age measures point to distinct aging phenotypes	60
The role of senescent T cells in immunopathology	59
Exercise reduces circulating biomarkers of cellular senescence in humans	58
Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity	58
Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects	55
JUNB‐FBXO21‐ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy	54
Fibronectin type III domain‐containing 5 improves aging‐related cardiac dysfunction in mice	53
The ketogenic diet preserves skeletal muscle with aging in mice	53
MiR‐103‐3p targets the m⁶A methyltransferase METTL14 to inhibit osteoblastic bone formation	53
Microglial MT1 activation inhibits LPS‐induced neuroinflammation via regulation of metabolic reprogramming	52
Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans	52
Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells	51
Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids	51
YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling	50
Age‐related thymic involution: Mechanisms and functional impact	50
Single human oocyte transcriptome analysis reveals distinct maturation stage‐dependent pathways impacted by age	50
Insights into T‐cell dysfunction in Alzheimer's disease	49
Senescent cells and the incidence of age‐related diseases	49
Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization	48
Alterations in mitochondrial dynamics with age‐related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility	48
TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1	48
Role of sleep quality in the acceleration of biological aging and its potential for preventive interaction on air pollution insults: Findings from the UK Biobank cohort	46
Late‐life exercise mitigates skeletal muscle epigenetic aging	46
Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats	45
Epigenetic clock and methylation studies in elephants	45
Is exercise a senolytic medicine? A systematic review	45
Alzheimer’s amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood‐brain barrier integrity, and angiogenesis	44
ATF3 drives senescence by reconstructing accessible chromatin profiles	44
Interleukin‐6 neutralization ameliorates symptoms in prematurely aged mice	44
Muscle mitochondrial energetics predicts mobility decline in well‐functioning older adults: The baltimore longitudinal study of aging	43
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway	43
G6PD overexpression protects from oxidative stress and age‐related hearing loss	42
Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging	42
Sex‐specific aging in animals: Perspective and future directions	41
Chronic low‐grade inflammation in heart failure with preserved ejection fraction	40
Antiallergic drug desloratadine as a selective antagonist of 5HT_2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction	40
PPARγ agonists delay age‐associated metabolic disease and extend longevity	40
Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism	39
Activation of angiotensin‐converting enzyme 2/angiotensin (1–7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling	39
Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway	39
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease	39
Functional genomic analyses highlight a shift in Gpr17‐regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum	39
Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress‐induced mitochondrial dysfunction	38
Disruption of ER‐mitochondria tethering and signalling in C9orf72‐associated amyotrophic lateral sclerosis and frontotemporal dementia	38
Mitochondrial stress and mitokines in aging	38
Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice	38
Metformin inhibits chronic kidney disease‐induced DNA damage and senescence of mesenchymal stem cells	38
NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation	38
Age‐related changes in hippocampal‐dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor	38
Modeling the human aging transcriptome across tissues, health status, and sex	37

Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease	37
Role of autophagy in aging: The good, the bad, and the ugly	36
Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single‐cell analysis	36
α‐ketoglutarate delays age‐related fertility decline in mammals	36
The lysosomal proteome of senescent cells contributes to the senescence secretome	36
Chaperone‐mediated autophagy degrades Keap1 and promotes Nrf2‐mediated antioxidative response	35
A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan	35
Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis	35
Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis	34
Platelet biomarkers for a descending cognitive function: A proteomic approach	34
Human age reversal: Fact or fiction?	34
Microbiota‐microglia connections in age‐related cognition decline	33
Metabolipidomic profiling reveals an age‐related deficiency of skeletal muscle pro‐resolving mediators that contributes to maladaptive tissue remodeling	33
Biological mechanisms of aging predict age‐related disease co‐occurrence in patients	33
Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging	33
The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF‐1α to inhibit knee osteoarthritis‐induced ferroptosis	33
The antagonistic pleiotropy of insulin‐like growth factor 1	32
Monomeric C‐reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype‐dependent pattern: A risk factor for Alzheimer’s disease?	31
Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome	31
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice	30
Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence	30
Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies	30
Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging	30
Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD⁺ signaling	30
Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan	30
Altered sperm tsRNAs in aged male contribute to anxiety‐like behavior in offspring	30
Inhibition of DNA methyltransferase aberrations reinstates antioxidant aging suppressors and ameliorates renal aging	29
Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation	29
Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease	29
Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations	29
Autophagic receptor p62 protects against glycation‐derived toxicity and enhances viability	29
NF‐κB/IKK activation by small extracellular vesicles within the SASP	29
Youthful and age‐related matreotypes predict drugs promoting longevity	28
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin	28
Intraocular iron injection induces oxidative stress followed by elements of geographic atrophy and sympathetic ophthalmia	28
Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol	28
Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice	28
TRIM33 protects osteoblasts from oxidative stress‐induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation	27
Advanced Maternal Age‐associated SIRT1 Deficiency Compromises Trophoblast Epithelial−Mesenchymal Transition through an Increase in Vimentin Acetylation	27
Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals	27
Epigenetic quantification of immunosenescent CD8⁺ TEMRA cells in human blood	27
Dysfunctional telomeres through mitostress‐induced cGAS/STING activation to aggravate immune senescence and viral pneumonia	27
Sex differences in telomere length, lifespan, and embryonic dyskerin levels	27
Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer's disease	27
Regulation and roles of RNA modifications in aging‐related diseases	27
Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging	27
Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma	26
Ganoderic acid D prevents oxidative stress‐induced senescence by targeting 14‐3‐3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells	26
Emerging rejuvenation strategies—Reducing the biological age	26
Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription	26
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy	26
Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock	26
Mitochondrial uncoupling protein‐2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age‐associated lung fibrosis	26
Aging influences the cardiac macrophage phenotype and function during steady state and during inflammation	26
p300 arrests intervertebral disc degeneration by regulating the FOXO3/Sirt1/Wnt/β‐catenin axis	25
Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia	25
Lycorine hydrochloride suppresses stress‐induced premature cellular senescence by stabilizing the genome of human cells	25
Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammaging	25
The metabolome as a biomarker of aging in Drosophila melanogaster	25
Production of MHCII‐expressing classical monocytes increases during aging in mice and humans	25
Aging impairs the essential contributions of non‐glial progenitors to neurorepair in the dorsal telencephalon of the Killifish Nothobranchius furzeri	25
A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence?	25
High‐fat diet‐induced obesity augments the deleterious effects of estrogen deficiency on bone: Evidence from ovariectomized mice	24
Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study	24
Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: Mechanisms and interventions	24
Advanced maternal age causes premature placental senescence and malformation via dysregulated α‐Klotho expression in trophoblasts	24
Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration	24
Cell nonautonomous roles of NHR‐49 in promoting longevity and innate immunity	24
Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain	24
Stress induced aging in mouse eye	24
Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration	24
Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice	24
α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease	24
Adipose tissue senescence is mediated by increased ATP content after a short‐term high‐fat diet exposure	23
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition	23
Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents	23
Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease	23
Single‐oocyte transcriptome analysis reveals aging‐associated effects influenced by life stage and calorie restriction	23
Role of Adiponectin‐Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exercise	23
Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function	23

Total and regional body adiposity increases during menopause—evidence from a follow‐up study	23
Dynamic regulation of myofibroblast phenotype in cellular senescence	22
Delineating the relationship between immune system aging and myogenesis in muscle repair	22
Effect of peripheral cellular senescence on brain aging and cognitive decline	22
Identification of distinct and age‐dependent p16^High microglia subtypes	22
VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease	22
The impact of aging on innate and adaptive immunity in the human female genital tract	22
NAMPT reduction‐induced NAD⁺ insufficiency contributes to the compromised oocyte quality from obese mice	22
Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging	22
Incomplete proline catabolism drives premature sperm aging	22
Dietary choline intake is necessary to prevent systems‐wide organ pathology and reduce Alzheimer's disease hallmarks	21
Partial reprogramming strategy for intervertebral disc rejuvenation by activating energy switch	21
Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis	21
Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease	21
DAF‐2/insulin IGF‐1 receptor regulates motility during aging by integrating opposite signaling from muscle and neuronal tissues	21
Senolytics alleviate the degenerative disorders of temporomandibular joint in old age	21
miR‐195‐3p alleviates homocysteine‐mediated atherosclerosis by targeting IL‐31 through its epigenetics modifications	21
A high‐fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App^{NL−F/NL−F} knock‐in mouse model	21
Exercise increases the release of NAMPT in extracellular vesicles and alters NAD⁺ activity in recipient cells	21
Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis	21
MAPK15 protects from oxidative stress‐dependent cellular senescence by inducing the mitophagic process	21
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ	21
Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics	21
Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes	21
Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM‐HET3 mice	21
Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease	21
Ouabain and chloroquine trigger senolysis of BRAF‐V600E‐induced senescent cells by targeting autophagy	21
Early growth response 2 (EGR2) is a novel regulator of the senescence programme	21
FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology	20
DNA methylation signatures in Blood DNA of Hutchinson–Gilford Progeria syndrome	20
Physiological clearance of Aβ by spleen and splenectomy aggravates Alzheimer‐type pathogenesis	20
5‐HT6R null mutatrion induces synaptic and cognitive defects	20
Cellular expansion of MSCs: Shifting the regenerative potential	20
Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle	20
Accelerated epigenetic aging in newborns with Down syndrome	20
Aging and cancer epigenetics: Where do the paths fork?	20
ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first‐degree relatives of type 2 diabetics	20
Innate immune remodeling by short‐term intensive fasting	20
Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population	20
Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B	20
3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex	20
Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription	20
REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons	19
Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice	19
Dioscin elevates lncRNA MANTIS in therapeutic angiogenesis for heart diseases	19
Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers	19
Different responses to DNA damage determine ageing differences between organs	19
Targeting age‐specific changes in CD4⁺ T cell metabolism ameliorates alloimmune responses and prolongs graft survival	19
Platelet biomarkers identifying mild cognitive impairment in type 2 diabetes patients	19
Late‐in‐life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts	19
The emergent role of mitochondrial surveillance in cellular health	19
“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation	19
Age‐related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats	19
Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice	18
Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice	18
Telomere length and metabolic syndrome traits: A Mendelian randomisation study	18
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging	18
Loss of legumain induces premature senescence and mediates aging‐related renal fibrosis	18
Single‐cell RNA‐Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation	18
Dissecting the influence of cellular senescence on cell mechanics and extracellular matrix formation in vitro	18
Proper control of R‐loop homeostasis is required for maintenance of gene expression and neuronal function during aging	18
Umbilical cord plasma concentrate has beneficial effects on DNA methylation GrimAge and human clinical biomarkers	18
Lysyl oxidase‐like 2 inhibitor rescues D‐galactose‐induced skeletal muscle fibrosis	17
Causal associations of sarcopenia‐related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study	17
Loss of miR‐34 in Drosophila dysregulates protein translation and protein turnover in the aging brain	17
Biomarkers of cellular senescence and risk of death in humans	17
Increasing skeletal muscle carnitine content in older individuals increases whole‐body fat oxidation during moderate‐intensity exercise	17
Knockdown of astrocytic Grin2a aggravates β‐amyloid‐induced memory and cognitive deficits through regulating nerve growth factor	17
Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR	17
Loss of heterochromatin and retrotransposon silencing as determinants in oocyte aging	17
The association between adverse childhood experiences and epigenetic age acceleration in the Canadian longitudinal study on aging (CLSA)	17
Interleukin‐37 improves T‐cell‐mediated immunity and chimeric antigen receptor T‐cell therapy in aged backgrounds	17
Genetic basis of enhanced stress resistance in long‐lived mutants highlights key role of innate immunity in determining longevity	17
Human muscle stem cells are refractory to aging	17
The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress	17
FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16^INK4a increase	17
Age‐dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution	16
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease	16
DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice	16
Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impairments	16
A circular intronic RNA ciPVT1 delays endothelial cell senescence by regulating the miR‐24‐3p/CDK4/pRb axis	16
Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing	16
NAD metabolism: Role in senescence regulation and aging	16
Aging‐related cell type‐specific pathophysiologic immune responses that exacerbate disease severity in aged COVID‐19 patients	16
2‐month ketogenic diet preferentially alters skeletal muscle and augments cognitive function in middle aged female mice	16
The age factor in optic nerve regeneration: Intrinsic and extrinsic barriers hinder successful recovery in the short‐living killifish	16
Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer’s disease	16
Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8⁺ T cells boost cancer cell elimination	16
Association between genetically determined telomere length and health‐related outcomes: A systematic review and meta‐analysis of Mendelian randomization studies	16
Age‐associated expression of p21and p53 during human wound healing	16
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β‐amyloid load in Alzheimer's disease model	16
Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy‐like retinal degeneration in a mouse model with iron overload	16
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy	15
System‐level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity	15
Ectopic cervical thymi and no thymic involution until midlife in naked mole rats	15