Aging Cell

Papers
(The median citation count of Aging Cell is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice220
Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo137
A genome‐wide association study of the frailty index highlights brain pathways in ageing127
Epigenetic age prediction102
mTORC2: The other mTOR in autophagy regulation101
On the evolution of cellular senescence98
Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans91
Necroptosis contributes to chronic inflammation and fibrosis in aging liver88
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study88
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity86
Mitochondrial DNA in extracellular vesicles declines with age85
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes84
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus80
Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging79
BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy77
Proteomics in aging research: A roadmap to clinical, translational research77
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming75
Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus73
NAD+ supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy67
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age66
Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells65
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis64
Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation64
α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease63
17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex63
Genetic associations for two biological age measures point to distinct aging phenotypes60
The role of senescent T cells in immunopathology59
Exercise reduces circulating biomarkers of cellular senescence in humans58
Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity58
Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects55
JUNB‐FBXO21‐ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy54
Fibronectin type III domain‐containing 5 improves aging‐related cardiac dysfunction in mice53
The ketogenic diet preserves skeletal muscle with aging in mice53
MiR‐103‐3p targets the m6A methyltransferase METTL14 to inhibit osteoblastic bone formation53
Microglial MT1 activation inhibits LPS‐induced neuroinflammation via regulation of metabolic reprogramming52
Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans52
Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells51
Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids51
YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling50
Age‐related thymic involution: Mechanisms and functional impact50
Single human oocyte transcriptome analysis reveals distinct maturation stage‐dependent pathways impacted by age50
Insights into T‐cell dysfunction in Alzheimer's disease49
Senescent cells and the incidence of age‐related diseases49
Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization48
Alterations in mitochondrial dynamics with age‐related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility48
TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT148
Role of sleep quality in the acceleration of biological aging and its potential for preventive interaction on air pollution insults: Findings from the UK Biobank cohort46
Late‐life exercise mitigates skeletal muscle epigenetic aging46
Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats45
Epigenetic clock and methylation studies in elephants45
Is exercise a senolytic medicine? A systematic review45
Alzheimer’s amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood‐brain barrier integrity, and angiogenesis44
ATF3 drives senescence by reconstructing accessible chromatin profiles44
Interleukin‐6 neutralization ameliorates symptoms in prematurely aged mice44
Muscle mitochondrial energetics predicts mobility decline in well‐functioning older adults: The baltimore longitudinal study of aging43
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway43
G6PD overexpression protects from oxidative stress and age‐related hearing loss42
Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging42
Sex‐specific aging in animals: Perspective and future directions41
Chronic low‐grade inflammation in heart failure with preserved ejection fraction40
Antiallergic drug desloratadine as a selective antagonist of 5HT2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction40
PPARγ agonists delay age‐associated metabolic disease and extend longevity40
Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism39
Activation of angiotensin‐converting enzyme 2/angiotensin (1–7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling39
Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway39
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease39
Functional genomic analyses highlight a shift in Gpr17‐regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum39
Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress‐induced mitochondrial dysfunction38
Disruption of ER‐mitochondria tethering and signalling in C9orf72‐associated amyotrophic lateral sclerosis and frontotemporal dementia38
Mitochondrial stress and mitokines in aging38
Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice38
Metformin inhibits chronic kidney disease‐induced DNA damage and senescence of mesenchymal stem cells38
NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation38
Age‐related changes in hippocampal‐dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor38
Modeling the human aging transcriptome across tissues, health status, and sex37
Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease37
Role of autophagy in aging: The good, the bad, and the ugly36
Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single‐cell analysis36
α‐ketoglutarate delays age‐related fertility decline in mammals36
The lysosomal proteome of senescent cells contributes to the senescence secretome36
Chaperone‐mediated autophagy degrades Keap1 and promotes Nrf2‐mediated antioxidative response35
A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan35
Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis35
Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis34
Platelet biomarkers for a descending cognitive function: A proteomic approach34
Human age reversal: Fact or fiction?34
Metabolipidomic profiling reveals an age‐related deficiency of skeletal muscle pro‐resolving mediators that contributes to maladaptive tissue remodeling33
Microbiota‐microglia connections in age‐related cognition decline33
Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging33
Biological mechanisms of aging predict age‐related disease co‐occurrence in patients33
The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF‐1α to inhibit knee osteoarthritis‐induced ferroptosis33
The antagonistic pleiotropy of insulin‐like growth factor 132
Monomeric C‐reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype‐dependent pattern: A risk factor for Alzheimer’s disease?31
Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome31
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice30
Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence30
Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies30
Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging30
Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling30
Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan30
Altered sperm tsRNAs in aged male contribute to anxiety‐like behavior in offspring30
Inhibition of DNA methyltransferase aberrations reinstates antioxidant aging suppressors and ameliorates renal aging29
Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation29
Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease29
Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations29
Autophagic receptor p62 protects against glycation‐derived toxicity and enhances viability29
NF‐κB/IKK activation by small extracellular vesicles within the SASP29
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin28
Intraocular iron injection induces oxidative stress followed by elements of geographic atrophy and sympathetic ophthalmia28
Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol28
Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice28
Youthful and age‐related matreotypes predict drugs promoting longevity28
Advanced Maternal Age‐associated SIRT1 Deficiency Compromises Trophoblast Epithelial−Mesenchymal Transition through an Increase in Vimentin Acetylation27
Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals27
Epigenetic quantification of immunosenescent CD8+ TEMRA cells in human blood27
Dysfunctional telomeres through mitostress‐induced cGAS/STING activation to aggravate immune senescence and viral pneumonia27
Sex differences in telomere length, lifespan, and embryonic dyskerin levels27
Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer's disease27
Regulation and roles of RNA modifications in aging‐related diseases27
Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging27
TRIM33 protects osteoblasts from oxidative stress‐induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation27
Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma26
Ganoderic acid D prevents oxidative stress‐induced senescence by targeting 14‐3‐3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells26
Emerging rejuvenation strategies—Reducing the biological age26
Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription26
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy26
Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock26
Mitochondrial uncoupling protein‐2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age‐associated lung fibrosis26
Aging influences the cardiac macrophage phenotype and function during steady state and during inflammation26
p300 arrests intervertebral disc degeneration by regulating the FOXO3/Sirt1/Wnt/β‐catenin axis25
Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia25
Lycorine hydrochloride suppresses stress‐induced premature cellular senescence by stabilizing the genome of human cells25
Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammaging25
The metabolome as a biomarker of aging in Drosophila melanogaster25
Production of MHCII‐expressing classical monocytes increases during aging in mice and humans25
Aging impairs the essential contributions of non‐glial progenitors to neurorepair in the dorsal telencephalon of the Killifish Nothobranchius furzeri25
A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence?25
Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: Mechanisms and interventions24
Advanced maternal age causes premature placental senescence and malformation via dysregulated α‐Klotho expression in trophoblasts24
Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration24
Cell nonautonomous roles of NHR‐49 in promoting longevity and innate immunity24
Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain24
Stress induced aging in mouse eye24
Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration24
Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice24
α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease24
High‐fat diet‐induced obesity augments the deleterious effects of estrogen deficiency on bone: Evidence from ovariectomized mice24
Physical activity is associated with slower epigenetic ageing—Findings from the Rhineland study24
Adipose tissue senescence is mediated by increased ATP content after a short‐term high‐fat diet exposure23
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition23
Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents23
Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease23
Single‐oocyte transcriptome analysis reveals aging‐associated effects influenced by life stage and calorie restriction23
Role of Adiponectin‐Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exercise23
Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function23
Total and regional body adiposity increases during menopause—evidence from a follow‐up study23
Dynamic regulation of myofibroblast phenotype in cellular senescence22
Delineating the relationship between immune system aging and myogenesis in muscle repair22
Effect of peripheral cellular senescence on brain aging and cognitive decline22
Identification of distinct and age‐dependent p16High microglia subtypes22
VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease22
The impact of aging on innate and adaptive immunity in the human female genital tract22
NAMPT reduction‐induced NAD+ insufficiency contributes to the compromised oocyte quality from obese mice22
Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging22
Incomplete proline catabolism drives premature sperm aging22
Partial reprogramming strategy for intervertebral disc rejuvenation by activating energy switch21
Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis21
Ouabain and chloroquine trigger senolysis of BRAF‐V600E‐induced senescent cells by targeting autophagy21
Early growth response 2 (EGR2) is a novel regulator of the senescence programme21
miR‐195‐3p alleviates homocysteine‐mediated atherosclerosis by targeting IL‐31 through its epigenetics modifications21
A high‐fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the AppNL−F/NL−F knock‐in mouse model21
Exercise increases the release of NAMPT in extracellular vesicles and alters NAD+ activity in recipient cells21
Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease21
Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis21
DAF‐2/insulin IGF‐1 receptor regulates motility during aging by integrating opposite signaling from muscle and neuronal tissues21
Senolytics alleviate the degenerative disorders of temporomandibular joint in old age21
Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics21
Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes21
Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM‐HET3 mice21
MAPK15 protects from oxidative stress‐dependent cellular senescence by inducing the mitophagic process21
Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease21
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ21
Dietary choline intake is necessary to prevent systems‐wide organ pathology and reduce Alzheimer's disease hallmarks21
3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex20
Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription20
FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology20
DNA methylation signatures in Blood DNA of Hutchinson–Gilford Progeria syndrome20
Physiological clearance of Aβ by spleen and splenectomy aggravates Alzheimer‐type pathogenesis20
5‐HT6R null mutatrion induces synaptic and cognitive defects20
Cellular expansion of MSCs: Shifting the regenerative potential20
Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle20
Accelerated epigenetic aging in newborns with Down syndrome20
Aging and cancer epigenetics: Where do the paths fork?20
ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first‐degree relatives of type 2 diabetics20
Innate immune remodeling by short‐term intensive fasting20
Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population20
Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B20
Late‐in‐life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts19
The emergent role of mitochondrial surveillance in cellular health19
“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation19
Age‐related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats19
REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons19
Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice19
Dioscin elevates lncRNA MANTIS in therapeutic angiogenesis for heart diseases19
Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers19
Different responses to DNA damage determine ageing differences between organs19
Targeting age‐specific changes in CD4+ T cell metabolism ameliorates alloimmune responses and prolongs graft survival19
Platelet biomarkers identifying mild cognitive impairment in type 2 diabetes patients19
Dissecting the influence of cellular senescence on cell mechanics and extracellular matrix formation in vitro18
Proper control of R‐loop homeostasis is required for maintenance of gene expression and neuronal function during aging18
Umbilical cord plasma concentrate has beneficial effects on DNA methylation GrimAge and human clinical biomarkers18
Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice18
Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice18
Telomere length and metabolic syndrome traits: A Mendelian randomisation study18
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging18
Loss of legumain induces premature senescence and mediates aging‐related renal fibrosis18
Single‐cell RNA‐Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation18
The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress17
FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16INK4a increase17
Lysyl oxidase‐like 2 inhibitor rescues D‐galactose‐induced skeletal muscle fibrosis17
Causal associations of sarcopenia‐related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study17
Loss of miR‐34 in Drosophila dysregulates protein translation and protein turnover in the aging brain17
Biomarkers of cellular senescence and risk of death in humans17
Increasing skeletal muscle carnitine content in older individuals increases whole‐body fat oxidation during moderate‐intensity exercise17
Knockdown of astrocytic Grin2a aggravates β‐amyloid‐induced memory and cognitive deficits through regulating nerve growth factor17
Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR17
Loss of heterochromatin and retrotransposon silencing as determinants in oocyte aging17
The association between adverse childhood experiences and epigenetic age acceleration in the Canadian longitudinal study on aging (CLSA)17
Interleukin‐37 improves T‐cell‐mediated immunity and chimeric antigen receptor T‐cell therapy in aged backgrounds17
Genetic basis of enhanced stress resistance in long‐lived mutants highlights key role of innate immunity in determining longevity17
Human muscle stem cells are refractory to aging17
Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8+ T cells boost cancer cell elimination16
Association between genetically determined telomere length and health‐related outcomes: A systematic review and meta‐analysis of Mendelian randomization studies16
Age‐associated expression of p21and p53 during human wound healing16
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β‐amyloid load in Alzheimer's disease model16
Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy‐like retinal degeneration in a mouse model with iron overload16
Age‐dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution16
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease16
DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice16
Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impairments16
A circular intronic RNA ciPVT1 delays endothelial cell senescence by regulating the miR‐24‐3p/CDK4/pRb axis16
Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing16
NAD metabolism: Role in senescence regulation and aging16
Aging‐related cell type‐specific pathophysiologic immune responses that exacerbate disease severity in aged COVID‐19 patients16
2‐month ketogenic diet preferentially alters skeletal muscle and augments cognitive function in middle aged female mice16
The age factor in optic nerve regeneration: Intrinsic and extrinsic barriers hinder successful recovery in the short‐living killifish16
Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer’s disease16
Ectopic cervical thymi and no thymic involution until midlife in naked mole rats15
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy15
System‐level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity15
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