OOIR: Observatory of International Research

Papers

(The H4-Index of Aging Cell is 46. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice	220
Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo	137
A genome‐wide association study of the frailty index highlights brain pathways in ageing	127
Epigenetic age prediction	102
mTORC2: The other mTOR in autophagy regulation	101
On the evolution of cellular senescence	98
Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans	91
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study	88
Necroptosis contributes to chronic inflammation and fibrosis in aging liver	88
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity	86
Mitochondrial DNA in extracellular vesicles declines with age	85
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes	84
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus	80
Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging	79
Proteomics in aging research: A roadmap to clinical, translational research	77
BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy	77
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming	75
Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus	73
NAD⁺ supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy	67
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age	66
Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells	65
Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation	64
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis	64
17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex	63
α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease	63

Genetic associations for two biological age measures point to distinct aging phenotypes	60
The role of senescent T cells in immunopathology	59
Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity	58
Exercise reduces circulating biomarkers of cellular senescence in humans	58
Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects	55
JUNB‐FBXO21‐ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy	54
MiR‐103‐3p targets the m⁶A methyltransferase METTL14 to inhibit osteoblastic bone formation	53
Fibronectin type III domain‐containing 5 improves aging‐related cardiac dysfunction in mice	53
The ketogenic diet preserves skeletal muscle with aging in mice	53
Microglial MT1 activation inhibits LPS‐induced neuroinflammation via regulation of metabolic reprogramming	52
Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans	52
Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids	51
Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells	51
Single human oocyte transcriptome analysis reveals distinct maturation stage‐dependent pathways impacted by age	50
YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling	50
Age‐related thymic involution: Mechanisms and functional impact	50
Senescent cells and the incidence of age‐related diseases	49
Insights into T‐cell dysfunction in Alzheimer's disease	49
Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization	48
Alterations in mitochondrial dynamics with age‐related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility	48
TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1	48
Late‐life exercise mitigates skeletal muscle epigenetic aging	46
Role of sleep quality in the acceleration of biological aging and its potential for preventive interaction on air pollution insults: Findings from the UK Biobank cohort	46