OOIR: Observatory of International Research

Papers

(The H4-Index of Aging Cell is 46. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation	290
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice	184
Underlying features of epigenetic aging clocks in vivo and in vitro	115
Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo	105
Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices	100
COVID‐19 is an emergent disease of aging	94
Targeting miR‐124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model	93
Determinants of accelerated metabolomic and epigenetic aging in a UK cohort	92
On the evolution of cellular senescence	83
Epigenetic age prediction	82
Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans	78
Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery	78
A genome‐wide association study of the frailty index highlights brain pathways in ageing	78
mTORC2: The other mTOR in autophagy regulation	75
Mitochondrial DNA in extracellular vesicles declines with age	75
Aging aggravated liver ischemia and reperfusion injury by promoting STING‐mediated NLRP3 activation in macrophages	72
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes	72
Cellular senescence as a potential mediator of COVID‐19 severity in the elderly	71
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity	70
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus	69
Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging	67
Thyroid hormones in diabetes, cancer, and aging	67
Necroptosis contributes to chronic inflammation and fibrosis in aging liver	65
Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling	65
Animal models of sarcopenia	63

DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study	62
Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice	62
BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy	61
Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging	60
Proteomics in aging research: A roadmap to clinical, translational research	57
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming	57
NAD⁺ supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy	56
Plasma proteomic profile of age, health span, and all‐cause mortality in older adults	56
Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells	53
Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus	53
Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease	53
The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high‐fat diet‐fed obese rats	53
The role of senescent T cells in immunopathology	51
α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease	50
Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease	49
17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex	48
Nuclear envelope dysfunction and its contribution to the aging process	48
miR‐181a regulates p62/SQSTM1, parkin, and protein DJ‐1 promoting mitochondrial dynamics in skeletal muscle aging	48
Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects	47
MiR‐103‐3p targets the m⁶A methyltransferase METTL14 to inhibit osteoblastic bone formation	47
Aging is associated with a decline in Atg9b‐mediated autophagosome formation and appearance of enlarged mitochondria in the heart	47
Exercise reduces circulating biomarkers of cellular senescence in humans	46