Nature Reviews Cancer

Article	Citations
Linking pancreatic renewal and cancer initiation	1581
Computing brain metastasis impact	1125
Digging for treasures in the tumour interactome	942
INVADEseq to study the intratumoural microbiota at host single-cell resolution	578
An inhospitable site	548
Combining spatial transcriptomics and AI to enhance brain tumour diagnosis	517
Fructose takes a detour to feed cancer	387
Combinatorial strategies to target RAS-driven cancers	364
Emerging strategies to investigate the biology of early cancer	364
Oncofetal reprogramming in tumour development and progression	344
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment	321
Artificial intelligence in cancer research, diagnosis and therapy	313
Mapping the prostate cell family tree	306
The evolution of cancer and ageing: a history of constraint	302
How medical anthropology can contribute to cancer research	302
Author Correction: Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma	289
Connie J. Eaves (1944–2024)	276
The recruitment of metastasis-associated monocytes	261
Antihistamines boost immunotherapy	257
Fighting cancer with fat	244
Tertiary lymphoid structures as hubs of antitumour immunity	243
Reply to ‘Heterogeneity of TP53 mutations necessitates differentiation with p53-rescue therapies’	242
The role of CRAF in cancer progression: from molecular mechanisms to precision therapies	239
Translating premalignant biology to accelerate non-small-cell lung cancer interception	224
Epithelial and stromal co-evolution and complicity in pancreatic cancer	220

Context-dependent functions of pattern recognition receptors in cancer	213
Targeting transcription cycles in cancer	202
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel	191
3D chromatin architecture as a predictor of somatic mutations in cancer genomes	190
No mutation, tumour initiation	185
Impersonating neurons	183
Under pressure	179
Nanoreceptors take down mutant p53	178
Gut microbes produce novel genotoxic metabolites	173
Tumour EVPs disrupt liver function	171
Dendritic cells rise and shine	170
Persistence is key	168
Removing barriers to address sex differences in anticancer drug toxicity	168
Thelpers? More like Ttroublemakers	166
AACR 2025	161
Measuring HLA disruption using MHC Hammer	158
Moonlighting functions of glucose metabolic enzymes and metabolites in cancer	155
Defining a ‘cells to society’ research framework for appendiceal tumours	151
Remodelling of the tumour microenvironment by the kallikrein-related peptidases	145
Natural killer cells in antitumour adoptive cell immunotherapy	143
3D bioprinted cancer models: from basic biology to drug development	142
How chemokines organize the tumour microenvironment	137
B-ring sterols to the rescue	127
Points of entry for tumour-infiltrating lymphocytes	127
Bone voyage: immune crosstalk sets sail	123
Identifying spatial cellular structures with SPACE-GM	122
In-depth organoid profiling of pancreatic cancer	117
Visualizing intratumoural heterogeneity with EpicMIBI	115
Environmental endocrine disruptors: rethinking the origins of early-onset ER+ breast cancer	114
Un-Fair Skin: racial disparities in acral melanoma research	112
Leveraging the replication stress response to optimize cancer therapy	108
The path to leptomeningeal metastasis	108
Metabolic interplays between the tumour and the host shape the tumour macroenvironment	107
Linking cell mechanical memory and cancer metastasis	107
Dynamics and specificities of T cells in cancer immunotherapy	103
Regulatory T cells in the tumour microenvironment	103
In situ decellularization of tissues to resolve the tumour-associated matrix	102
Encoding spatial tumour dynamics with Starfysh	97
Race influences the tumour microbiome	97
Understanding and addressing race disparities in childhood cancer outcomes	97
Taming TAMs in brain metastases	97
Deciphering the cancer genome and epigenome	96
Don’t blame the messenger: lessons learned for cancer mRNA vaccines during the COVID-19 pandemic	95
The link between vitamin D and prostate cancer	95
Polygenic scores in cancer	94
Targeted protein degradation for cancer therapy	92
Acetyl-CoA metabolism in cancer	88
Cancer nanomedicine	86
RNA splicing dysregulation and the hallmarks of cancer	84
Z-nucleic acids give immunotherapy a boost	82

Local CAR manufacturing	80
Author Correction: Antibody-based proteomics: fast-tracking molecular diagnostics in oncology	80
Parity modulates epithelial–immune cell communication	76
Right ON target: a new RAS-GTP inhibitor	74
Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities	72
Defining precancer: a grand challenge for the cancer community	71
Integrative medicine in oncology: redefining the standard of care	69
A trojan horse to target spliceosome mutant cells	68
NOTUM-mediated stem cell competition in CRC	67
Prime editing GEMMs to model cancer mutations	67
Expanding the utility of precision oncology knowledge bases	65
Chromothripsis in cancer	61
Tertiary lymphoid structures in anticancer immunity	60
Targeting ferroptosis as a vulnerability in cancer	59
Starting a new job	56
Quantum probes in cancer research	55
Functional lineage tracing to study the clonal evolution of therapy resistance	54
In vivo labelling system to study cell neighbourhoods	50
Revealing genomic secrets of archival FFPE samples	49
Judith Campisi (1948–2024)	48
New pathogen on the block	48
Glycogen condensates drive tumorigenesis by trapping Hippo kinases	46
The present and future of the Cancer Dependency Map	45
Recent advances in therapeutic cancer vaccines	45
Neutrophils: a roadblock for immunotherapy	45
Immune-checkpoint inhibitor-mediated myocarditis: CTLA4, PD1 and LAG3 in the heart	44
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data	42
Inferring cancer metabolism from gene-expression data	42
Carcinogenesis at single-cell resolution	39
Cell states can give tumorigenesis a head start	38
Bidirectional CART.BiTE cells bring new hope	35
Global post-mortem tissue donation programmes to accelerate cancer research	34
Patient-derived organoids unveil sarcoma vulnerabilities	34
Transfer RNAs as dynamic and critical regulators of cancer progression	32
Epigenomic heterogeneity as a source of tumour evolution	32
Evolution and progression of Barrett’s oesophagus to oesophageal cancer	32
Developing dietary interventions as therapy for cancer	30
A timeline of tumour-associated macrophage biology	30
Traject3d for studying 3D cellular heterogeneity	29
Digitally enhanced Raman spectroscopy	28
Harnessing the influenza virus to fight cancer	28
Author Correction: Integrative medicine in oncology: redefining the standard of care	28
Neuro-immune cross-talk in cancer	27
Guardrails for the use of generalist AI in cancer care	26
Targeting cancer cell dormancy	25
Fcγ receptors and immunomodulatory antibodies in cancer	24
Structural variations in cancer and the 3D genome	24
We cannot ignore the cancer risks of wildfires	24
The role of ROS in tumour development and progression	24
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity	22
mRNA-based cancer therapeutics	22
Frozen silicified vaccines	21
AACR 2024	21
Ethnically diverse cancer cell lines for drug testing	21
Next-generation epidemiologic cohorts for cancer aetiology	20
Male melanoma comes of age	20
Fungi in cancer: not such a ‘fun-guy’	19
EMT in chemoresistance	18
CAFs promote CRPC	17
Mechanisms driving the immunoregulatory function of cancer cells	17
Modelling and deciphering tumour metabolism in CRISPR screens	17
Decoding the functional impact of the cancer genome through protein–protein interactions	17
Advances in cutaneous squamous cell carcinoma	16
The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment	16
Silent mutations make noise	14
Key role for microbiota in gut–bone crosstalk	14
Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ	13
Stabilizing the mood of tumours	12
Multiomics-guided cellular immunotherapies	12
Inflammatory neutrophils	11
Energizing leukaemia	11
Deep tissue imaging of cancer in the infrared	10
Advances in translational research of the rare cancer type adrenocortical carcinoma	10
Disconnecting multicellular networks in brain tumours	10
Same same but different	10
Decoding the basis of histological variation in human cancer	9
Stemness in solid malignancies: coping with immune attack	9
Enhanced transposable elements	8
Exploiting senescence for the treatment of cancer	8
Air pollution promotes tumorigenesis through pre-existing oncogenic mutations	8

Therapeutic resistance to anti-oestrogen therapy in breast cancer	8
Black voices in cancer research and oncology	7
Glioblastomas remodel neural circuits	7
Too much of a good thing	7
Targeting sex steroid biosynthesis for breast and prostate cancer therapy	7
Mapping out mitochondria	7
Limiting bias in AI models for improved and equitable cancer care	6
Overcoming heterogeneity with 3D whole-tumour sampling	6
Fungi in cancer	6
Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection	6
Androgen receptor activation for breast cancer therapy	6
Addressing the gaps in cancer screening for LGBTQ+ individuals	5
Nucleotide metabolism: a pan-cancer metabolic dependency	5
Breast milk for breast cancer detection	5
Aristolochic acid-associated cancers: a public health risk in need of global action	5
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment	5
Hubs of transcriptional activity	5
Big data in basic and translational cancer research	5
Proximity labelling to study chromatin interactomes	5
Pathogenesis of cancers derived from thyroid follicular cells	5
Towards cancer equity via patient outreach	4
Tumour avatars to model patients’ responses to immunotherapy	4
Defining and using immune archetypes to classify and treat cancer	4
Obesity as a promoter in BRCA mutation carriers	4
Tracing the evolutionary history of breast cancer	4
Feeding latent brain metastasis	4
Intercepting gastric cancer	4
Polyamines in cancer: integrating organismal metabolism and antitumour immunity	4
Epigenetic memory	4
VIBRANT: mapping cell phenotypes using vibrational spectroscopy	4
Modelling the ageing dependence of cancer evolutionary trajectories	4
Conventional chemotherapy: millions of cures, unresolved therapeutic index	4
Understanding tumour endothelial cell heterogeneity and function from single-cell omics	4
The fibroinflammatory response in cancer	4
Small speckles, big impact	4
scAtlasVAE: a deep learning framework for generating a human CD8+ T cell atlas	3
Targeting the roots of myeloid malignancies with T cell receptors	3
Lymphatic vessels in the age of cancer immunotherapy	3
Multiplex protein imaging in tumour biology	3
Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma	3
A machine learning toolkit for subtyping cancer in existing and new datasets	3
Replication timings affect the frequency of chromosomal translocation	3
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications	3
Protection against tumour formation	3
Studying extrachromosomal DNA with the ecTag method	3
Enhancing cellular immunotherapies in cancer by engineering selective therapeutic resistance	3
Exploiting temporal aspects of cancer immunotherapy	3
Allies in the epidermis	2
Taking a detour	2
How protons pave the way to aggressive cancers	2
Epigenetic lesions drive gliomagenesis	2
Pressing defence	2
Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention	2
Lactate gives a sour taste	2
Sex affects cancer genomes	2
Bringing community to our pages	2
Expanding oesophageal cancer research and care in eastern Africa	2
Nanotherapy: targeting the tumour microenvironment	2
Shared immunosuppressive mechanism between pregnancy and cancer	2
Managing cancer following the World Trade Center disaster	2
Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities	2
Naughty neutrophils	2
Cancer’s sensory experience	2
Mastering the use of cellular barcoding to explore cancer heterogeneity	2
Hidden epithelial subtypes refine colorectal cancer classification	2
PDX models for functional precision oncology and discovery science	2
Heard immunity in CAR T cells	2
The dynamic role of platelets in cancer progression and their therapeutic implications	2
Rusting away with age	2
Author Correction: The importance of 3D fibre architecture in cancer and implications for biomaterial model design	2
Gender and sex interactions are intrinsic components of cancer phenotypes	2
Liquid biopsies for Hodgkin lymphoma	2
NET-working under stress	2
Targeting aberrant splicing	2
Targeting the tumour’s little helpers	2
Stromal cells drive tumorigenesis in BRCA1 mutation carriers	2
Oncologists must act to manage cancer detected through prenatal screening	2
Harnessing multimodal data integration to advance precision oncology	2
Ageing lipids map melanoma’s journey	2
Presenting fibroblasts	2
Advancing cancer research via comparative oncology	2
Salmonella, the insidious contributor to gallbladder and colon cancers	2
Overcoming TGFβ-mediated immune evasion in cancer	2
Tumour hypoxia in driving genomic instability and tumour evolution	2
Preprints as tools to advance careers	2