Nature Reviews Cancer

Article	Citations
Computing brain metastasis impact	1628
Digging for treasures in the tumour interactome	1168
Linking pancreatic renewal and cancer initiation	976
An inhospitable site	604
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment	563
Combining spatial transcriptomics and AI to enhance brain tumour diagnosis	535
INVADEseq to study the intratumoural microbiota at host single-cell resolution	401
Combinatorial strategies to target RAS-driven cancers	376
Oncofetal reprogramming in tumour development and progression	374
Fructose takes a detour to feed cancer	364
Emerging strategies to investigate the biology of early cancer	339
Implementing practice-changing progress for managing cancer of unknown primary	334
How medical anthropology can contribute to cancer research	318
Mapping the prostate cell family tree	317
Fighting cancer with fat	308
Reply to ‘Heterogeneity of TP53 mutations necessitates differentiation with p53-rescue therapies’	307
3D chromatin architecture as a predictor of somatic mutations in cancer genomes	280
Translating premalignant biology to accelerate non-small-cell lung cancer interception	265
Author Correction: Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma	262
Connie J. Eaves (1944–2024)	261
The recruitment of metastasis-associated monocytes	253
Antihistamines boost immunotherapy	248
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel	246
The role of CRAF in cancer progression: from molecular mechanisms to precision therapies	225
Epithelial and stromal co-evolution and complicity in pancreatic cancer	219

The evolution of cancer and ageing: a history of constraint	209
Tertiary lymphoid structures as hubs of antitumour immunity	200
Context-dependent functions of pattern recognition receptors in cancer	196
Targeting transcription cycles in cancer	194
Gut microbes produce novel genotoxic metabolites	193
Under pressure	188
No mutation, tumour initiation	185
Impersonating neurons	183
Nanoreceptors take down mutant p53	183
Tumour EVPs disrupt liver function	177
Dendritic cells rise and shine	177
AACR 2025	173
Measuring HLA disruption using MHC Hammer	170
Removing barriers to address sex differences in anticancer drug toxicity	164
Persistence is key	158
Defining a ‘cells to society’ research framework for appendiceal tumours	152
Thelpers? More like Ttroublemakers	146
Moonlighting functions of glucose metabolic enzymes and metabolites in cancer	144
Remodelling of the tumour microenvironment by the kallikrein-related peptidases	141
Natural killer cells in antitumour adoptive cell immunotherapy	137
3D bioprinted cancer models: from basic biology to drug development	131
Environmental endocrine disruptors: rethinking the origins of early-onset ER+ breast cancer	126
How chemokines organize the tumour microenvironment	126
Un-Fair Skin: racial disparities in acral melanoma research	121
Bone voyage: immune crosstalk sets sail	120
B-ring sterols to the rescue	118
Identifying spatial cellular structures with SPACE-GM	116
In-depth organoid profiling of pancreatic cancer	116
Visualizing intratumoural heterogeneity with EpicMIBI	115
The path to leptomeningeal metastasis	111
The immune microenvironment of colorectal cancer	111
Points of entry for tumour-infiltrating lymphocytes	111
Regulatory T cells in the tumour microenvironment	105
Leveraging the replication stress response to optimize cancer therapy	105
Linking cell mechanical memory and cancer metastasis	102
Metabolic interplays between the tumour and the host shape the tumour macroenvironment	100
In situ decellularization of tissues to resolve the tumour-associated matrix	100
Dynamics and specificities of T cells in cancer immunotherapy	100
Encoding spatial tumour dynamics with Starfysh	99
Understanding and addressing race disparities in childhood cancer outcomes	99
Race influences the tumour microbiome	98
Deciphering the cancer genome and epigenome	97
Don’t blame the messenger: lessons learned for cancer mRNA vaccines during the COVID-19 pandemic	95
The link between vitamin D and prostate cancer	95
Polygenic scores in cancer	90
Acetyl-CoA metabolism in cancer	86
RNA splicing dysregulation and the hallmarks of cancer	82
Cancer nanomedicine	81
Taming TAMs in brain metastases	81
Targeted protein degradation for cancer therapy	80

Local CAR manufacturing	77
Z-nucleic acids give immunotherapy a boost	77
Parity modulates epithelial–immune cell communication	76
Right ON target: a new RAS-GTP inhibitor	74
Author Correction: Antibody-based proteomics: fast-tracking molecular diagnostics in oncology	74
Prime editing GEMMs to model cancer mutations	67
Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities	67
Chromothripsis in cancer	65
Integrative medicine in oncology: redefining the standard of care	62
Expanding the utility of precision oncology knowledge bases	61
A trojan horse to target spliceosome mutant cells	61
Tamoxifen takes the wheel	59
NOTUM-mediated stem cell competition in CRC	59
Targeting ferroptosis as a vulnerability in cancer	58
Defining precancer: a grand challenge for the cancer community	58
Tertiary lymphoid structures in anticancer immunity	54
Starting a new job	50
Neutrophils: a roadblock for immunotherapy	49
In vivo labelling system to study cell neighbourhoods	48
Revealing genomic secrets of archival FFPE samples	47
Functional lineage tracing to study the clonal evolution of therapy resistance	46
Judith Campisi (1948–2024)	46
Quantum probes in cancer research	46
New pathogen on the block	43
Glycogen condensates drive tumorigenesis by trapping Hippo kinases	42
Inferring cancer metabolism from gene-expression data	37
The present and future of the Cancer Dependency Map	36
Immune-checkpoint inhibitor-mediated myocarditis: CTLA4, PD1 and LAG3 in the heart	36
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data	35
Recent advances in therapeutic cancer vaccines	35
Carcinogenesis at single-cell resolution	34
Patient-derived organoids unveil sarcoma vulnerabilities	33
Bidirectional CART.BiTE cells bring new hope	32
Global post-mortem tissue donation programmes to accelerate cancer research	32
Transfer RNAs as dynamic and critical regulators of cancer progression	32
A timeline of tumour-associated macrophage biology	29
Developing dietary interventions as therapy for cancer	29
Focusing on the complex and dynamic interplay between ageing and cancer	29
Epigenomic heterogeneity as a source of tumour evolution	29
Traject3d for studying 3D cellular heterogeneity	28
Author Correction: Integrative medicine in oncology: redefining the standard of care	27
Digitally enhanced Raman spectroscopy	27
We cannot ignore the cancer risks of wildfires	26
Mechanisms and treatment of cancer therapy-induced peripheral and central neurotoxicity	26
Targeting cancer cell dormancy	25
Fcγ receptors and immunomodulatory antibodies in cancer	24
mRNA-based cancer therapeutics	24
Structural variations in cancer and the 3D genome	24
Harnessing the influenza virus to fight cancer	23
Guardrails for the use of generalist AI in cancer care	22
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity	22
Neuro-immune cross-talk in cancer	22
The role of ROS in tumour development and progression	21
AACR 2024	20
Next-generation epidemiologic cohorts for cancer aetiology	19
Frozen silicified vaccines	19
Ethnically diverse cancer cell lines for drug testing	18
The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment	17
Male melanoma comes of age	17
Modelling and deciphering tumour metabolism in CRISPR screens	16
Fungi in cancer: not such a ‘fun-guy’	16
CAFs promote CRPC	16
Advances in cutaneous squamous cell carcinoma	14
Decoding the functional impact of the cancer genome through protein–protein interactions	13
Mechanisms driving the immunoregulatory function of cancer cells	13
Silent mutations make noise	13
EMT in chemoresistance	13
Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ	12
Disconnecting multicellular networks in brain tumours	12
Multiomics-guided cellular immunotherapies	12
Stabilizing the mood of tumours	12
Energizing leukaemia	12
Same same but different	11
Decoding the basis of histological variation in human cancer	11
Stemness in solid malignancies: coping with immune attack	10
Advances in translational research of the rare cancer type adrenocortical carcinoma	10
Deep tissue imaging of cancer in the infrared	10
Inflammatory neutrophils	8
Therapeutic resistance to anti-oestrogen therapy in breast cancer	8
Key role for microbiota in gut–bone crosstalk	8

Androgen receptor activation for breast cancer therapy	7
Addressing the gaps in cancer screening for LGBTQ+ individuals	7
Glioblastomas remodel neural circuits	7
Too much of a good thing	7
Air pollution promotes tumorigenesis through pre-existing oncogenic mutations	7
Exploiting senescence for the treatment of cancer	7
Targeting sex steroid biosynthesis for breast and prostate cancer therapy	7
Mapping out mitochondria	7
Enhanced transposable elements	7
Aristolochic acid-associated cancers: a public health risk in need of global action	6
Pathogenesis of cancers derived from thyroid follicular cells	6
Nucleotide metabolism: a pan-cancer metabolic dependency	6
Black voices in cancer research and oncology	6
Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection	6
Big data in basic and translational cancer research	6
Overcoming heterogeneity with 3D whole-tumour sampling	5
Hubs of transcriptional activity	5
Fungi in cancer	5
Modelling the ageing dependence of cancer evolutionary trajectories	5
Limiting bias in AI models for improved and equitable cancer care	5
Tumour avatars to model patients’ responses to immunotherapy	5
Proximity labelling to study chromatin interactomes	5
Feeding latent brain metastasis	5
Breast milk for breast cancer detection	5
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment	5
Intercepting gastric cancer	5
Polyamines in cancer: integrating organismal metabolism and antitumour immunity	4
Understanding tumour endothelial cell heterogeneity and function from single-cell omics	4
Small speckles, big impact	4
Studying extrachromosomal DNA with the ecTag method	4
Defining and using immune archetypes to classify and treat cancer	4
Epigenetic memory	4
Tracing the evolutionary history of breast cancer	4
Obesity as a promoter in BRCA mutation carriers	4
The fibroinflammatory response in cancer	4
Conventional chemotherapy: millions of cures, unresolved therapeutic index	4
VIBRANT: mapping cell phenotypes using vibrational spectroscopy	4
Lymphatic vessels in the age of cancer immunotherapy	3
Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma	3
Targeting the roots of myeloid malignancies with T cell receptors	3
Protection against tumour formation	3
Enhancing cellular immunotherapies in cancer by engineering selective therapeutic resistance	3
Replication timings affect the frequency of chromosomal translocation	3
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications	3
Overcoming TGFβ-mediated immune evasion in cancer	2
Pressing defence	2
Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention	2
Taking a detour	2
NET-working under stress	2
Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities	2
Oncologists must act to manage cancer detected through prenatal screening	2
Targeting aberrant splicing	2
How protons pave the way to aggressive cancers	2
Presenting fibroblasts	2
The dynamic role of platelets in cancer progression and their therapeutic implications	2
scAtlasVAE: a deep learning framework for generating a human CD8+ T cell atlas	2
Managing cancer following the World Trade Center disaster	2
Shared immunosuppressive mechanism between pregnancy and cancer	2
Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer	2
Aggregating premalignancy	2
Harnessing multimodal data integration to advance precision oncology	2
Hidden epithelial subtypes refine colorectal cancer classification	2
Preprints as tools to advance careers	2
Cancer’s sensory experience	2
Naughty neutrophils	2
Epigenetic lesions drive gliomagenesis	2
Mastering the use of cellular barcoding to explore cancer heterogeneity	2
Bringing community to our pages	2
Author Correction: The importance of 3D fibre architecture in cancer and implications for biomaterial model design	2
Lactate gives a sour taste	2
Multiplex protein imaging in tumour biology	2
Heard immunity in CAR T cells	2
Rusting away with age	2
Nanotherapy: targeting the tumour microenvironment	2
Tumour hypoxia in driving genomic instability and tumour evolution	2
Liquid biopsies for Hodgkin lymphoma	2
PDX models for functional precision oncology and discovery science	2
Stromal cells drive tumorigenesis in BRCA1 mutation carriers	2
Allies in the epidermis	2
Advancing cancer research via comparative oncology	2
Targeting the tumour’s little helpers	2
Ageing lipids map melanoma’s journey	2
Expanding oesophageal cancer research and care in eastern Africa	2
Sex affects cancer genomes	2
Exploiting temporal aspects of cancer immunotherapy	2
A machine learning toolkit for subtyping cancer in existing and new datasets	2
Identification, functional insights and therapeutic targeting of EMT tumour states	2
Salmonella, the insidious contributor to gallbladder and colon cancers	2
Gender and sex interactions are intrinsic components of cancer phenotypes	2