Nature Reviews Immunology

Article	Citations
The cGAS–STING pathway as a therapeutic target in inflammatory diseases	1060
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity	1023
A guide to vaccinology: from basic principles to new developments	886
Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape	877
Viral targets for vaccines against COVID-19	842
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities	751
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19	678
Neutralizing monoclonal antibodies for treatment of COVID-19	594
Inflammation and immune dysfunction in Parkinson disease	592
COVID-19 vaccines: modes of immune activation and future challenges	568
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?	550
CD8+ T cell differentiation and dysfunction in cancer	522
Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy	457
Immunological mechanisms of vaccine-induced protection against COVID-19 in humans	453
The roles of extracellular vesicles in the immune system	443
Mucosal vaccines — fortifying the frontiers	380
Mitochondrial control of inflammation	368
The inflammatory pathogenesis of colorectal cancer	366
IL-17 and IL-17-producing cells in protection versus pathology	358
Neutrophils in cancer: heterogeneous and multifaceted	354
The first 12 months of COVID-19: a timeline of immunological insights	342
A guide to antigen processing and presentation	319
Metabolic barriers to cancer immunotherapy	315
Fibroblasts as immune regulators in infection, inflammation and cancer	309
Interferon-γ: teammate or opponent in the tumour microenvironment?	302

Death by TNF: a road to inflammation	299
CD8+ T cell metabolism in infection and cancer	286
Redox regulation of immunometabolism	286
Regulation of immune responses by the airway epithelial cell landscape	281
Immune cell-mediated features of non-alcoholic steatohepatitis	277
Monkeypox: disease epidemiology, host immunity and clinical interventions	270
Natural killer cells in antiviral immunity	265
Immunobiology and pathogenesis of hepatitis B virus infection	261
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity	250
Inflammasome activation at the crux of severe COVID-19	237
Regulation of inflammation by the antioxidant haem oxygenase 1	237
SARS-CoV-2 breakthrough infections in vaccinated individuals: measurement, causes and impact	235
The type I interferonopathies: 10 years on	233
Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection	228
Roles of natural killer cells in immunity to cancer, and applications to immunotherapy	218
Immunomodulation by endothelial cells — partnering up with the immune system?	212
Neuromodulation by the immune system: a focus on cytokines	211
Tissue-specific macrophages: how they develop and choreograph tissue biology	204
Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses	197
Autoantibodies in neurological disease	186
The state of complement in COVID-19	185
The immunology of long COVID	178
Understanding COVID-19-associated coagulopathy	178
Regulation of the nucleic acid-sensing Toll-like receptors	176
The germinal centre B cell response to SARS-CoV-2	173
Estimating disease severity of Omicron and Delta SARS-CoV-2 infections	164
The impact of the gut microbiome on extra-intestinal autoimmune diseases	163
Engineering IL-2 for immunotherapy of autoimmunity and cancer	163
Immune ageing at single-cell resolution	161
The immunology of multiple sclerosis	158
Immune-mediated inflammatory disease therapeutics: past, present and future	156
Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases	156
Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders	156
Allergen immunotherapy: past, present and future	155
Will SARS-CoV-2 variants of concern affect the promise of vaccines?	153
Targeting IL-6 trans-signalling: past, present and future prospects	142
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies	142
Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms	140
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?	139
Bacterial origins of human cell-autonomous innate immune mechanisms	136
Tissue regulatory T cells: regulatory chameleons	136
Tuning immunity through tissue mechanotransduction	134
NOD-like receptor-mediated plant immunity: from structure to cell death	133
Milder disease with Omicron: is it the virus or the pre-existing immunity?	132
TCF1 in T cell immunity: a broadened frontier	125
SARS-CoV-2 infection and COVID-19 vaccination in pregnancy	125
Cellular networks controlling T cell persistence in adoptive cell therapy	122
Immunomodulation by radiotherapy in tumour control and normal tissue toxicity	121
The biology of TREM receptors	118
DNA damage and repair in age-related inflammation	117

Are COVID-19 vaccines safe in pregnancy?	117
Phase separation in immune signalling	116
Host-directed immunotherapy of viral and bacterial infections: past, present and future	114
Is IL-6 a key cytokine target for therapy in COVID-19?	113
The role of T cells in age-related diseases	109
The multifunctional protein HMGB1: 50 years of discovery	107
Diversity and dynamism of IgA−microbiota interactions	107
Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases	105
Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?	105
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues	102
Immune responses to human fungal pathogens and therapeutic prospects	102
Myeloid cell-targeted therapies for solid tumours	98
A guide to interrogating immunometabolism	98
Role of thymic stromal lymphopoietin in allergy and beyond	97
The role of galectins in immunity and infection	97
The interplay of immunology and cachexia in infection and cancer	95
The link between circulating follicular helper T cells and autoimmunity	94
Can we predict T cell specificity with digital biology and machine learning?	93
The spatio-temporal control of effector T cell migration	92
Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination	91
The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses	89
Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation	88
The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?	86
Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection	85
Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines	82
Short-chain fatty acids: linking diet, the microbiome and immunity	82
Omicron, the great escape artist	80
B cells in central nervous system disease: diversity, locations and pathophysiology	79
Lessons in self-defence: inhibition of virus entry by intrinsic immunity	76
Organellar homeostasis and innate immune sensing	72
RHO GTPases: from new partners to complex immune syndromes	71
Innate immune detection of lipid oxidation as a threat assessment strategy	70
Cerebral dysfunctions caused by sepsis during ageing	70
The NLR gene family: from discovery to present day	70
COVID-19 and cellular senescence	70
The therapeutic age of the neonatal Fc receptor	70
Immune and non-immune functions of adipose tissue leukocytes	69
The role of platelets in immune-mediated inflammatory diseases	67
The unique properties of IgG4 and its roles in health and disease	67
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1	65
Heterogeneity of type 2 innate lymphoid cells	64
Memory B cells	63
The role of chromatin loop extrusion in antibody diversification	63
Expanding dendritic cell nomenclature in the single-cell era	63
Gasdermins: making pores for pyroptosis	62
Understanding COVID-19 in Africa	60
Endemic SARS-CoV-2 will maintain post-pandemic immunity	59
A guide to thymic selection of T cells	57
Omicron entry route	56
Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease	56
New perspectives on the origins and heterogeneity of mast cells	55
T cell-oriented strategies for controlling the COVID-19 pandemic	55
Engaging innate immunity in HIV-1 cure strategies	53
Modelling vaccination strategies for COVID-19	51
SARS-CoV-2 hybrid immunity: silver bullet or silver lining?	49
Signals of hope: gauging the impact of a rapid national vaccination campaign	48
Tumour immunotherapy: lessons from predator–prey theory	47
Clonal haematopoiesis and dysregulation of the immune system	46
Glomerulonephritis: immunopathogenesis and immunotherapy	45
Immune activation in irritable bowel syndrome: what is the evidence?	45
Structural insights into the evolution of the RAG recombinase	45
Local immune recognition of trophoblast in early human pregnancy: controversies and questions	45
A guide to complement biology, pathology and therapeutic opportunity	44
TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective	42
Inflammatory cytokines and cardiac arrhythmias: the lesson from COVID-19	42
SARS-CoV-2: from herd immunity to hybrid immunity	41
SARS-CoV-2 infection and COVID-19 in asthmatics: a complex relationship	37
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations	36
Regulatory T cells in the face of the intestinal microbiota	36
Decoding bat immunity: the need for a coordinated research approach	35
Human stem cell models to study host–virus interactions in the central nervous system	34
The role of transcription factors in shaping regulatory T cell identity	32
Control of immune cell function by the unfolded protein response	32
Localization, tissue biology and T cell state — implications for cancer immunotherapy	32
Microglia regulation of central nervous system myelin health and regeneration	32
The role of PI3Kγ in the immune system: new insights and translational implications	31
Challenges in developing personalized neoantigen cancer vaccines	31
Protein kinases: drug targets for immunological disorders	31
Immunological barriers to haematopoietic stem cell gene therapy	30
CRISPR screens for functional interrogation of immunity	30

Strategies for targeting cytokines in inflammatory bowel disease	30
Publisher Correction: A guide to vaccinology: from basic principles to new developments	28
ORF9c and ORF10 as accessory proteins of SARS-CoV-2 in immune evasion	28
Human and planetary health on fire	28