OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Immunology is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-07-01 to 2026-07-01.)

Article	Citations
Regulation goes awry in the liver	1243
Heart failure affects innate immune memory	1050
Early life antibiotics have lasting effects on the lung epithelium	904
Natural killer cells that target autoimmune cells linked with protection against multiple sclerosis	902
Exercise induces metabolic changes in the gut microbiota that enhance anti-tumour T cell responses	817
Decoding the human prenatal immune system with single-cell multi-omics	554
Muscle spindle macrophages regulate motor coordination	451
Albumin protects against deadly fungal infection	444
BCG plus β-glucan trains neutrophils to beat bladder cancer	429
Human immune organoids: a tool to study vaccine responses	427
Author Correction: Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies	398
Metabolite and nutrient regulation of macrophages in obesity and metabolic disease	377
The danger theory of immunity revisited	374
Viral infection and antiviral immunity in the oral cavity	355
The immunology of asthma and chronic rhinosinusitis	344
Macrophages in embryonic development	341
Shaping neutrophil morphology and function: the importance of a segmented nucleus	341
Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses	338
Regulation of cGAS–STING signalling and its diversity of cellular outcomes	328
Challenges in developing personalized neoantigen cancer vaccines	326
Human T follicular regulatory cells with helper and regulatory lineage origins	315
Targeting malaria transmission	315
Fatty liver disease induced by maternal obesity is driven by metabolic rewiring of Kupffer cells	298
Neutrophils are dispensable for Shigella control: macrophages take centre stage	285
Stressed tumours release immunosuppressive vesicles	270

The distinctive immune features of long COVID	269
Encouraging vaccine uptake: lessons from behavioural science	263
Novel insights into the immune response to bacterial T cell superantigens	263
Mechanistic insights from inflammasome structures	241
A guide to adaptive immune memory	221
The NLR gene family: from discovery to present day	214
Antiviral neutralizing antibodies: from in vitro to in vivo activity	204
How bile acids and the microbiota interact to shape host immunity	203
Mapping the developmental trajectory and recruitment of memory-phenotype Ly49+CD8+ T cells	201
Blood neutrophil subset predicts the success of immune checkpoint inhibitors in cancer	198
You are what you ate: myeloid cells trained by fatty acids	196
T cell–eosinophil collaboration	194
Gut ILC2s remember IL-25	191
The kiss a cell can’t forget: tracking cell–cell interactions with uLIPSTIC	185
Online immunology education for a global world	179
Adaptive meets innate: CD8+ T cells kill MHC-I-negative tumour cells	179
The cancer-immune dialogue in the context of stress	177
Splenic stromal niches in homeostasis and immunity	170
Salt sensitivity includes effects on immune cell signalling and metabolism	169
Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease	169
Why pigs might help us develop better vaccines and drugs against influenza virus	158
The OrganiX microfluidic system to recreate the complex tumour microenvironment	153
Feeding IgA+ plasma cells	151
JAKs drive innate-like TH9 cell activation in allergy	145
Negative regulation of fungal immunity by STING	136
Spatial resolution of host–microbiome interactions	134
An ILC3-intrinsic, CTLA4-dependent intestinal checkpoint	132
Low risk of CAR T cells going rogue	132
Bacteria in tumours promote cancer progression	128
Monocytes rule energy metabolism with an iron fist	128
Neutrophils make matrix to fortify barrier immunity	125
The immunopathogenesis of narcolepsy type 1	124
Monkeypox: disease epidemiology, host immunity and clinical interventions	124
Calibrating T cell responsiveness through interactions with self	124
Author Correction: Cancer cell metabolism and antitumour immunity	120
Olfactory immunology: the missing piece in airway and CNS defence	120
The spatial and temporal activation of macrophages during fibrosis	117
Eosinophils shape barrier immunity during reproduction	115
The biology of TREM receptors	113
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies	110
Microenvironmental regulation of solid tumour resistance to CAR T cell therapy	105
Rejuvenation through checkpoint inhibitors?	98
Commensal fungi support granulocyte development	95
Publisher Correction: Immunological studies in trans-individuals undergoing gender affirming hormone therapy	92
T cells target viral protein to remove senescent fibroblasts	91
mRNA vaccine for treating pancreatic cancer	88
Early life allergen sensitivity starts in the skin	85
Cytokine multimerization: when more is more and sometimes less	85
Spatial immunometabolic zonation in tuberculosis granulomas	80
Podoplanin mediates stromal–immune crosstalk in the lymph node	79

Guardians of immune privilege	77
Germinal centre IL-4 enforces tissue confinement of IgE memory	76
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases	72
The promise of immunotherapy for central nervous system tumours	71
Local immune recognition of trophoblast in early human pregnancy: controversies and questions	70
T cell engagers in autoimmune diseases	69
Glomerulonephritis: immunopathogenesis and immunotherapy	68
Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers	67
MR1 antigen presentation to MAIT cells and other MR1-restricted T cells	65
DNA damage and repair in age-related inflammation	62
We need to keep an eye on avian influenza	61
Neutralizing autoantibodies against type 1 interferons identified in West Nile virus encephalitis	60
Bacterial serotonin induces Treg cells in neonates	60
Pollution impairs lung defences with age	60
Lung-resident memory B cells class-switch to IgE	56
Boosting cytotoxic T cells for immunotherapy	56
Early antiviral type I interferon impairs lung metastasis	56
Actin branching maintains tissue-resident mast cells	53
Hypoxia and IL-24 drive a sterile wound healing pathway	52
Asymptomatic SARS-CoV-2 linked to HLA-B*15:01	52
Turning on anti-tumour T cells via MTAP	52
Microbiota licenses protective CD8+ T cell responses against neonatal influenza	52
CODEX multiplexed tissue imaging	51
Insights into immune cell–fibroblast communication in heart disease	51
T cell-derived extracellular vesicles promote antitumour immunity through horizontal gene transfer	50
Integrated organ immunity: a path to a universal vaccine	50
The renaissance of oral tolerance: merging tradition and new insights	49
Defining myeloid-derived suppressor cells	48
Vaginal NK cells limit epithelial barrier disruption during infection	48
IL-17 and IL-17-producing cells in protection versus pathology	48
Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection	48
Extrafollicular plasma cells suppress T cell priming in tumour-draining lymph nodes	47
Effect of prenatal stress on the developing brain	47
Bacteria tag tumours for CAR T cell attack	46
The autoinflammatory disease APLAID is driven by G-CSF	46
PerturbView: scalable image-based perturbation screens in cells and tissues	45
Boosting glymphatic drainage via adrenergic receptor inhibition protects the injured brain	44
Disturbance of cytoskeleton primes RIG-I-like receptors	43
Immunology of food aversion	43
NK cell mechanosensing through CD16a	42
NMDAR-directed CAAR T cells show promise for autoimmune encephalitis	42
Author Correction: The immunology of long COVID	41
Understanding COVID-19-associated coagulopathy	38
The role of transcription factors in shaping regulatory T cell identity	38
Mitochondria in monocyte-derived cells promote tissue damage in multiple sclerosis	38
Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies	38
The ageing immune system as a driver of systemic ageing	37
The role of galectins in immunity and infection	37
Targeting ER stress sensor restores immunogenicity of chemotherapy	36
Harnessing mucosal immunity for protective vaccines	36
CARD8 kills CD4+ T cells in response to HIV entry	35
Transposon-derived decoy fine-tunes IFN responses	35
Author Correction: The role of platelets in immune-mediated inflammatory diseases	34
Inhibition of NR4A1 potentiates a CD8+ T cell response against active tuberculosis	32
Macrophages bordering the brain parenchyma regulate the flow of cerebrospinal fluid	32
Metabolites as signalling molecules in the tumour immune microenvironment	31
CRISPR screen reveals regulators of age-associated CD8+ T cell dysfunction in cancer	31
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors	30
Contextualizing TH17 cells in cancer	30
The diversity of CD8+ T cell dysfunction in cancer and viral infection	29
Protective and pathological roles of immunothrombosis in sepsis	29
CRISPR screens for functional interrogation of immunity	28
Regulation of innate-like activities of neonatal CD8+ T cells	28
Macrophage quality control of HSCs	28
Human ILC2s can act as cytolytic killers	27
Unconventional T cells shape tissue-specific lymph node responses	26
Obesity-associated autoreactivity	25
Focusing on the correct gene signatures for SLE	24
Fetal Treg cell reprogramming links maternal immunity to neurodevelopment	23
Publisher Correction: Inflammasome components as new therapeutic targets in inflammatory disease	23
Osteoblast-derived ATP maintains bone marrow plasma cells	23