Nature Reviews Immunology

Article	Citations
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity	882
The cGAS–STING pathway as a therapeutic target in inflammatory diseases	855
Viral targets for vaccines against COVID-19	826
Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape	806
Immunological considerations for COVID-19 vaccine strategies	782
A guide to vaccinology: from basic principles to new developments	770
T cell responses in patients with COVID-19	680
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19	626
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities	618
Neutralizing monoclonal antibodies for treatment of COVID-19	566
COVID-19 vaccines: modes of immune activation and future challenges	534
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?	472
Inflammation and immune dysfunction in Parkinson disease	459
Immunological mechanisms of vaccine-induced protection against COVID-19 in humans	434
Tissue damage from neutrophil-induced oxidative stress in COVID-19	430
CD8+ T cell differentiation and dysfunction in cancer	422
COVID-19 herd immunity: where are we?	398
Lactate modulation of immune responses in inflammatory versus tumour microenvironments	378
Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy	376
The role of IgG Fc receptors in antibody-dependent enhancement	349
The first 12 months of COVID-19: a timeline of immunological insights	332
Mucosal vaccines — fortifying the frontiers	323
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns	323
The inflammatory pathogenesis of colorectal cancer	316
The type I interferon response in COVID-19: implications for treatment	311

The roles of extracellular vesicles in the immune system	302
Neutrophils in cancer: heterogeneous and multifaceted	283
Metabolic barriers to cancer immunotherapy	276
Fibroblasts as immune regulators in infection, inflammation and cancer	265
Mitochondrial control of inflammation	262
γδ T cells in tissue physiology and surveillance	261
Interferon-γ: teammate or opponent in the tumour microenvironment?	255
A guide to antigen processing and presentation	252
IL-17 and IL-17-producing cells in protection versus pathology	249
Redox regulation of immunometabolism	247
Regulation of immune responses by the airway epithelial cell landscape	241
Not just antibodies: B cells and T cells mediate immunity to COVID-19	239
Monkeypox: disease epidemiology, host immunity and clinical interventions	230
CD8+ T cell metabolism in infection and cancer	227
Immunobiology and pathogenesis of hepatitis B virus infection	226
Inflammasome activation at the crux of severe COVID-19	223
Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection	223
Immune cell-mediated features of non-alcoholic steatohepatitis	222
Cross-reactive memory T cells and herd immunity to SARS-CoV-2	221
Natural killer cells in antiviral immunity	220
SARS-CoV-2 breakthrough infections in vaccinated individuals: measurement, causes and impact	218
Regulation of inflammation by the antioxidant haem oxygenase 1	202
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity	197
Targeting CD39 in cancer	195
Neuromodulation by the immune system: a focus on cytokines	184
The type I interferonopathies: 10 years on	184
Death by TNF: a road to inflammation	177
Transcriptional regulation of memory B cell differentiation	175
The state of complement in COVID-19	171
Genetic models of human and mouse dendritic cell development and function	167
The germinal centre B cell response to SARS-CoV-2	163
Constitutive immune mechanisms: mediators of host defence and immune regulation	162
Autoantibodies in neurological disease	161
Understanding COVID-19-associated coagulopathy	156
Immunomodulation by endothelial cells — partnering up with the immune system?	153
A few good peptides: MHC class I-based cancer immunosurveillance and immunoevasion	153
Early life microbial exposures and allergy risks: opportunities for prevention	152
Will SARS-CoV-2 variants of concern affect the promise of vaccines?	152
How transcription factors drive choice of the T cell fate	152
Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses	151
Roles of natural killer cells in immunity to cancer, and applications to immunotherapy	150
Regulation of the nucleic acid-sensing Toll-like receptors	146
Estimating disease severity of Omicron and Delta SARS-CoV-2 infections	145
Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders	142
Immune ageing at single-cell resolution	142
Rethinking peripheral T cell tolerance: checkpoints across a T cell’s journey	134
Milder disease with Omicron: is it the virus or the pre-existing immunity?	131
Engineering IL-2 for immunotherapy of autoimmunity and cancer	128
Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms	127
Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19	127

Immune-mediated inflammatory disease therapeutics: past, present and future	125
The impact of the gut microbiome on extra-intestinal autoimmune diseases	123
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?	123
Tissue regulatory T cells: regulatory chameleons	119
The immunology of multiple sclerosis	117
Bacterial origins of human cell-autonomous innate immune mechanisms	117
TCF1 in T cell immunity: a broadened frontier	116
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies	115
Are COVID-19 vaccines safe in pregnancy?	114
The immunology of long COVID	114
NOD-like receptor-mediated plant immunity: from structure to cell death	113
Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models	111
Tissue-specific macrophages: how they develop and choreograph tissue biology	111
Glucocorticoids in T cell development, differentiation and function	109
SARS-CoV-2 infection and COVID-19 vaccination in pregnancy	107
Neuronal regulation of immunity: why, how and where?	107
T cell regeneration after immunological injury	105
Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases	104
Is IL-6 a key cytokine target for therapy in COVID-19?	104
Allergen immunotherapy: past, present and future	102
Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?	101
Cellular networks controlling T cell persistence in adoptive cell therapy	101
After 62 years of regulating immunity, dexamethasone meets COVID-19	99
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues	96
Immunomodulation by radiotherapy in tumour control and normal tissue toxicity	96
Phase separation in immune signalling	94
Tuning immunity through tissue mechanotransduction	94
The role of T cells in age-related diseases	93
A guide to interrogating immunometabolism	92
Host-directed immunotherapy of viral and bacterial infections: past, present and future	90
Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination	87
Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases	85
Diversity and dynamism of IgA−microbiota interactions	84
Myeloid cell-targeted therapies for solid tumours	84
Immune responses to human fungal pathogens and therapeutic prospects	83
DNA damage and repair in age-related inflammation	83
The spatio-temporal control of effector T cell migration	83
Targeting IL-6 trans-signalling: past, present and future prospects	82
The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?	82
Omicron, the great escape artist	80
The interplay of immunology and cachexia in infection and cancer	76
Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection	75
Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation	70
The biology of TREM receptors	70
The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses	68
B cells in central nervous system disease: diversity, locations and pathophysiology	68
Lessons in self-defence: inhibition of virus entry by intrinsic immunity	67
The link between circulating follicular helper T cells and autoimmunity	66
IL-9-producing T cells: potential players in allergy and cancer	64
Role of thymic stromal lymphopoietin in allergy and beyond	64
RHO GTPases: from new partners to complex immune syndromes	63
Innate immune detection of lipid oxidation as a threat assessment strategy	63
The multifunctional protein HMGB1: 50 years of discovery	63
COVID-19 and cellular senescence	62
Organellar homeostasis and innate immune sensing	62
Functional categories of immune inhibitory receptors	61
Can we predict T cell specificity with digital biology and machine learning?	61
Immune and non-immune functions of adipose tissue leukocytes	61
Heterogeneity of type 2 innate lymphoid cells	59
The role of chromatin loop extrusion in antibody diversification	58
Can we harness the microbiota to enhance the efficacy of cancer immunotherapy?	58
Understanding COVID-19 in Africa	58
Expanding dendritic cell nomenclature in the single-cell era	58
Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines	57
Endemic SARS-CoV-2 will maintain post-pandemic immunity	57
Cerebral dysfunctions caused by sepsis during ageing	56
T cell-oriented strategies for controlling the COVID-19 pandemic	55
Do cross-reactive antibodies cause neuropathology in COVID-19?	54
Gasdermins: making pores for pyroptosis	54
The role of galectins in immunity and infection	53
The role of platelets in immune-mediated inflammatory diseases	52
Omicron entry route	52
Immunometabolism and HIV-1 pathogenesis: food for thought	52
Keeping track of the SARS-CoV-2 vaccine pipeline	51
The therapeutic age of the neonatal Fc receptor	48
Modelling vaccination strategies for COVID-19	48
Signals of hope: gauging the impact of a rapid national vaccination campaign	48
SARS-CoV-2 hybrid immunity: silver bullet or silver lining?	45
New perspectives on the origins and heterogeneity of mast cells	45
Engaging innate immunity in HIV-1 cure strategies	45

The NLR gene family: from discovery to present day	45
The unique properties of IgG4 and its roles in health and disease	45
A call to arms: helping family, friends and communities navigate the COVID-19 infodemic	45
Tumour immunotherapy: lessons from predator–prey theory	44
Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease	42
Determining the effector response to cell death	41
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1	41
SARS-CoV-2: from herd immunity to hybrid immunity	40
Immune activation in irritable bowel syndrome: what is the evidence?	38
Structural insights into the evolution of the RAG recombinase	38
Inflammatory cytokines and cardiac arrhythmias: the lesson from COVID-19	37
SARS-CoV-2 infection and COVID-19 in asthmatics: a complex relationship	37
Local immune recognition of trophoblast in early human pregnancy: controversies and questions	34
Memory B cells	33
Human stem cell models to study host–virus interactions in the central nervous system	33