OOIR: Observatory of International Research

Papers

(The median citation count of Nature Reviews Immunology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Linking the maternal milk microbiota and infant respiratory infections	1105
Lactation-associated macrophages	1061
Maternal infection programmes offspring immunity	887
Revealing T follicular helper cells with BCL6	683
Understanding COVID-19-associated coagulopathy	622
TCF1 in T cell immunity: a broadened frontier	594
Modelling vaccination strategies for COVID-19	574
XXtra killer cells	550
Comparing neurological complications after COVID-19 vaccination and SARS-CoV-2 infection	539
Tissue-specific epigenomics of resident memory CD8+ T cells	480
First glimpses into the mechanisms of Long COVID	455
Social distancing plus rapid vaccination prevents emergence of SARS-CoV-2 variants	453
TSLP uses up fats to coat the skin	389
Sucralose: not sweet enough for T cells	383
The autoinflammatory disease APLAID is driven by G-CSF	380
Cross-reactive tissue-resident CD8+ T cells may provide first line of defence against SARS-CoV-2	375
Microbiome effects on immune surveillance of intestinal tumours	365
The mole rat’s secret to cancer resistance	342
IgA selects for fit, peace-loving fungi	327
Sensing extracellular ATP boosts memory T cell commitment	319
Heart failure affects innate immune memory	315
Low serotonin linked to long COVID	309
Inflammatory cytokines and cardiac arrhythmias: the lesson from COVID-19	302
Thymic masqueraders	287
Neutralization susceptibility of Omicron lineages	286

When ‘mild’ COVID-19 is not so mild	276
Dexamethasone restrains neutrophils in severe COVID-19	264
Time of day determines cancer immunotherapy response	261
How the brain regulates inflammation	250
Immunology of food aversion	247
Pyroptotic cell products promote tissue repair	240
How neuroinflammation weakens muscles	237
Early life antibiotics have lasting effects on the lung epithelium	229
A guide to complement biology, pathology and therapeutic opportunity	228
Inflammatory rewiring	226
Taking AIM2 at atherosclerotic plaques	224
A pan-cancer signature for dysfunctional T cells	211
Seeing SARS-CoV-2 variants through the eyes of T cells	197
A pre-TCRα-independent pathway of αβ T cell differentiation	191
Boosting glymphatic drainage via adrenergic receptor inhibition protects the injured brain	190
Adipose tissue maintains healthy joint fibroblasts via cortisol signalling	186
Effect of prenatal stress on the developing brain	185
Antitumour roles for antihistamines	185
Sensing proteotoxic stress	183
Three-dimensional genome organization in immune cell fate and function	178
Cholesterol controls tolerogenic versus immunogenic DCs	169
‘Prime and spike’ induces mucosal immunity and reduces SARS-CoV-2 transmission	168
Orally delivered lactate-producing bacteria limit CNS autoimmunity	167
NMDAR-directed CAAR T cells show promise for autoimmune encephalitis	165
Novel insights into double-stranded RNA-mediated immunopathology	163
Bacteria tag tumours for CAR T cell attack	163
Understanding NK cell heterogeneity	162
Natural killer cells that target autoimmune cells linked with protection against multiple sclerosis	158
The brain tumour microenvironment imparts neutrophils with pro-tumour properties	156
B cell-derived acetylcholine curbs haematopoiesis	155
The epigenetic ghost of infections past	152
Regulation goes awry in the liver	149
ComplexEye: a multi-lens array microscope for high-throughput cell migration analysis	143
Vaccines only partially protect against Long COVID	139
The inflammatory pathogenesis of colorectal cancer	136
Immunomodulation by radiotherapy in tumour control and normal tissue toxicity	132
Will SARS-CoV-2 variants of concern affect the promise of vaccines?	132
Defining the TH17 cell lineage	130
Omicron, the great escape artist	127
Ancient DNA reveals evolutionary origins of autoimmune diseases	125
Human immune organoids: a tool to study vaccine responses	123
Charge-based immunoreceptor signalling in health and disease	123
Viral infection and antiviral immunity in the oral cavity	118
Decoding the human prenatal immune system with single-cell multi-omics	117
Same yet different — how lymph node heterogeneity affects immune responses	117
Using art and history to communicate immunology to a broad audience	116
Macrophage commonalities across tissues and inflammation	116
Tuning immunity through tissue mechanotransduction	113
Challenges in developing personalized neoantigen cancer vaccines	110
Antigen presentation for central tolerance induction	109

Mitochondria in monocyte-derived cells promote tissue damage in multiple sclerosis	109
Myeloid cell-targeted therapies for solid tumours	109
TGFβ control of immune responses in cancer: a holistic immuno-oncology perspective	105
Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies	105
Immunomodulation by endothelial cells — partnering up with the immune system?	98
SARS-CoV-2 infection and COVID-19 vaccination in pregnancy	96
COVID-19 vaccines: modes of immune activation and future challenges	95
Regulation of cGAS–STING signalling and its diversity of cellular outcomes	95
Modified uridines are the key to a successful message	95
Expanding dendritic cell nomenclature in the single-cell era	93
ORF9c and ORF10 as accessory proteins of SARS-CoV-2 in immune evasion	93
Sex-specific role for microglial CST7 in Alzheimer’s disease	92
The role of transcription factors in shaping regulatory T cell identity	91
Brain regulatory T cells	89
The immunology of type 1 diabetes	88
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1	86
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity	85
Memory B cells	82
The role of T cells in age-related diseases	81
The impact of the gut microbiome on extra-intestinal autoimmune diseases	81
Neutralizing monoclonal antibodies for treatment of COVID-19	80
A guide to thymic selection of T cells	79
Author Correction: The immunology of long COVID	76
Author Correction: The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting	75
Lymphocytes in lockdown	71
The danger theory of immunity revisited	70
Author Correction: Do rogue antibodies make the difference between mild versus severe COVID-19?	70
Author Correction: Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies	69
Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses	69
Clonal haematopoiesis-associated, age-related motor deficits caused by monocyte-derived microglia	68
Innate IL-13 licenses dermal type 2 dendritic cells for efficient T helper 2 cell responses	67
Disturbance of cytoskeleton primes RIG-I-like receptors	65
Natural killer cells in antiviral immunity	65
Host-directed immunotherapy of viral and bacterial infections: past, present and future	63
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues	63
Role of thymic stromal lymphopoietin in allergy and beyond	63
Immune responses to human fungal pathogens and therapeutic prospects	62
The role of galectins in immunity and infection	60
Muscle spindle macrophages regulate motor coordination	57
Inflammasome components as new therapeutic targets in inflammatory disease	57
Red blood cells join the ranks as immune sentinels	57
Understanding vertebrate immunity through comparative immunology	56
The distinctive immune features of long COVID	56
CLASH: large-scale engineering system for the discovery of better CAR T cells	55
Complement in maternal milk shapes the infant microbiome	53
Neutrophil surface RNAs promote entry to inflamed sites	51
Autoimmune TCRs cross-react with microbial and self-antigens	50
Glia mend the gut	49
Stressed tumours release immunosuppressive vesicles	48
IKKβ ignites the inflammasome	47
Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease	47
Vitamin D for COVID-19: where are we now?	47
A broken immune clock in old macrophages	45
Stepping off the cGAS during mitosis	45
Targeting autoantibodies in COVID-19	45
Rather active for ‘exhausted’ T cells	44
Taking CAR T cells up a synthetic Notch	44
Teaching old brains new immune tricks	42
Respiratory syncytial virus after the SARS-CoV-2 pandemic — what next?	41
Platelet-derived 5-HIAA helps neutrophils enter tissue	39
Fasting affects monocyte lifespan and migration	37
Harnessing our lived experience for science communication	36
Noncanonical inflammasome mediates BBB breakdown	36
Optimizing pig organs for human transplantation	35
Self-reactive MAIT cells are common in healthy individuals	32
Inflammation and immune dysfunction in Parkinson disease	32
Mucosal vaccines — fortifying the frontiers	32
The cGAS–STING pathway as a therapeutic target in inflammatory diseases	32
Author Correction: The role of platelets in immune-mediated inflammatory diseases	31
Vitamin D shuts down T cell-mediated inflammation	30
Gut commensals promote antiviral immunity via extracellular vesicles	30
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?	30
Autoantibodies against chemokines linked with better disease outcomes in COVID-19	30
CARD8 kills CD4+ T cells in response to HIV entry	28
Vaccine safety in an era of novel vaccines: a proposed research agenda	28
Omicron alone provides limited cross-protection	27
Reindeer antlers model skin regeneration	27
Targeting malaria transmission	26
Commensals shape the immune system	25
A protective role for interferon-ε in ovarian cancer	25

Are variant-specific vaccines warranted?	25
Brief diet changes affect immunity	24
Linking Epstein-Barr virus infection to multiple sclerosis	24
SARS-CoV-2 and HIV-1 — a tale of two vaccines	23
SARS-CoV-2 Delta variant excels at membrane fusion, but not immune evasion	23
The NLR gene family: from discovery to present day	23
Which came first, T cells or B cells?	23
The immunology of multiple sclerosis	22
Systematic identification of cell state-specific transcription factors in T cells	22
ILC3-induced regulatory T cells are directed by gut microorganisms	21
Rejuvenating an old immune system	21
CD8+ T cell differentiation and dysfunction in cancer	21
Human T follicular regulatory cells with helper and regulatory lineage origins	21
Breast cancer-associated fibroblasts maintain self-renewing immunosuppressive macrophages	20
CAR T cells take to the airways	19
Macrophages bordering the brain parenchyma regulate the flow of cerebrospinal fluid	18
IL-17A–HIF1α axis in epithelial wound repair	18
Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?	18
Role of the microbiota in response to and recovery from cancer therapy	17
Reclassifying plasmacytoid dendritic cells as innate lymphocytes	17
Metabolism as a driver of immunity	17
Vax-Innate: improving therapeutic cancer vaccines by modulating T cells and the tumour microenvironment	16
The roles of arginases and arginine in immunity	16
Non-classical monocytes have the support of the whole vascular tree	16
Mitochondrial tonic for adoptive T cell therapies	16
Antiviral neutralizing antibodies: from in vitro to in vivo activity	16
Lessons from vaccine-induced immune thrombotic thrombocytopenia	15
Adipokines: masterminds of metabolic inflammation	14
Unique properties of tissue-resident memory T cells in the lungs: implications for COVID-19 and other respiratory diseases	14
Gasdermins: making pores for pyroptosis	14
Entering the neutrophil trap	14
Author Correction: Will SARS-CoV-2 variants of concern affect the promise of vaccines?	13
Novel insights into the immune response to bacterial T cell superantigens	13
Author Correction: Are COVID-19 vaccines safe in pregnancy?	12
Author Correction: Protein kinases: drug targets for immunological disorders	12
Publisher Correction: Immune activation in irritable bowel syndrome: what is the evidence?	12
Locally sourced: site-specific immune barriers to metastasis	11
B cells in central nervous system disease: diversity, locations and pathophysiology	11
Author Correction: A guide to thymic selection of T cells	11
Swarm immunology: harnessing blockchain technology and artificial intelligence in human immunology	10
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity	10
Immune dysregulation in Down syndrome	10
The therapeutic age of the neonatal Fc receptor	10
Black In Immuno: harnessing social media and digital platforms to connect the dots	10
New perspectives on the origins and heterogeneity of mast cells	9
Targeting ER stress sensor restores immunogenicity of chemotherapy	9
Fibroblasts as immune regulators in infection, inflammation and cancer	9
The role of PI3Kγ in the immune system: new insights and translational implications	9
The conneXion between sex and immune responses	9
Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection	9
Breaking tolerance: the autoimmune aspect of atherosclerosis	9
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?	9
NFAT: platelet stickiness regulator	9
A guide to adaptive immune memory	8
How bile acids and the microbiota interact to shape host immunity	8
CRISPR screens for functional interrogation of immunity	8
Mechanistic insights from inflammasome structures	8
Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines	8
Encouraging vaccine uptake: lessons from behavioural science	8
An inter-organ neuro–immuno–endocrine circuit for glucose homeostasis	7
Transposon-derived decoy fine-tunes IFN responses	7
Lung-migrating helminths can enhance immunity to SARS-CoV-2	7
Publisher Correction: SARS-CoV-2 and HIV-1 — a tale of two vaccines	7
‘Transcriptotype’ explains phenotypic variability of inborn errors of immunity	7
Trained immunity in chronic inflammatory diseases and cancer	7
Bile duct tuft cells regulate immune defences	7
Biomolecular condensates in immune cell fate	7
Author Correction: Inflammasome components as new therapeutic targets in inflammatory disease	7
Lymphatic expression of TBX1 helps to heal the heart	7
Serial killing enabled by T cell receptor ectocytosis	7
Diabetes enhances viral loads in COVID-19	6
T cell–eosinophil collaboration	6
Bispecific agonist boosts anti-tumour T cells via GITR	6
Image-seq: image-guided cell isolation for spatially resolved transcriptomic analysis	6
Signal length not strength guides T cell fate	6
Adaptive meets innate: CD8+ T cells kill MHC-I-negative tumour cells	6
Comparing paediatric COVID-19 with MIS-C	6
Cross-reactive memory T cells abort SARS-CoV-2 infection	6
Tissue macrophages break dogma	6
The kiss a cell can’t forget: tracking cell–cell interactions with uLIPSTIC	6
The OrganiX microfluidic system to recreate the complex tumour microenvironment	6
Cross reactive T cells hold up against Omicron	5
Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases	5
Copper boosts pro-inflammatory state of macrophages	5
Heterogeneity of type 2 innate lymphoid cells	5
Human ILC2s can act as cytolytic killers	5
The broad spectrum of pathogenic autoreactivity	5
Reservoirs of allergic memory	5
Tracking the infant immune response to SARS-CoV-2	5
The link between circulating follicular helper T cells and autoimmunity	5
Fc-optimized monoclonal antibodies show superior efficacy	5
Obesity-associated autoreactivity	4
You are what you ate: myeloid cells trained by fatty acids	4
Focusing on the correct gene signatures for SLE	4
Detecting future coronavirus pandemics	4