OOIR: Observatory of International Research

Papers

(The TQCC of Expert Review of Molecular Diagnostics is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Harnessing the potential of genomic characterization of mutational profiles to improve early diagnosis of lung cancer	97
Cost analyses for malaria molecular diagnosis for research planners in India and beyond	60
Molecular point-of-care testing in the community pharmacy setting: current status and future prospects	55
Mild behavioral impairment and neurodegeneration: time for a biomarker-based assessment	53
Clinicopathological, etiological and molecular characteristics of intrahepatic cholangiocarcinoma subtypes classified by mucin production and immunohistochemical features	47
Evaluating tumor cell- and T cell-derived extracellular vesicles as potential biomarkers of cancer and immune cell competence	36
Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer	36
Evolution and future of cervical cancer screening: from cytology to primary HPV testing and the impact of vaccination	33
Recent updates in the development of molecular assays for the rapid identification and susceptibility testing of MRSA	33
What makes a « good » companion diagnostic in thoracic oncology?	32
Functional proteomic analysis, a missing piece for understanding clonal evolution and cooperation in the tissue microecology	31
Unlocking the power of biomarkers: transforming the diagnosis of acute respiratory distress syndrome	30
A novel anoikis-related signature predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma	28
Evaluating emerging molecular diagnostics for severe infections in neutropenic patients with hematological malignancies	28
The MALAT1-breast cancer interplay: insights and implications	26
Diagnosing thrombophilia: the case for genetic or functional testing?	25
Diagnostic approach to leptomeningeal involvement in diffuse large B-cell lymphoma	25
Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis	24
CRISPR-Cas system: recent advancements in prompt diagnosis of high-risk HPV genotypes in cervical cancer	23
Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma	23
How mitochondrial DNA complicates pre-implantation genetic screening and management	22
Genetic risk and gastric cancer: polygenic risk scores in population-based case-control study	22
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease	21
Navigating PD-L1 testing in immuno-oncology: analytical robustness, clinical validation, and the role of the VENTANA SP263 assay	21
Can multiplex molecular panels of microbial pathogens transform respiratory care in critically ill patients?	20

Clinical application of noninvasive prenatal testing in twin pregnancies: a single-center experience	20
The promise of liquid biopsies in prostate cancer: a potential point-of-care modality for precision oncology	20
Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers	20
Protein signatures for the early detection of endometrial cancer in cervico-vaginal fluid	19
Mutation profiling of chronic myeloproliferative neoplasms: improving clinical-molecular prognostic models	19
The clinical importance of high-sensitivity cardiac troponin measurements for risk prediction in non-cardiac surgery	19
Cell avidity in CAR-T cell therapy	19
The integration of biomarkers and patient-reported outcomes improves prediction of interstitial cystitis syndrome	18
Molecular predictors of metastasis in patients with prostate cancer	18
Optimization of time interval for the measurement of plasma lipids for cardiovascular disease risk assessment	18
LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis	17
α-synuclein PET imaging: early human evidence and the path toward clinical proof-of-concept	17
Molecular diagnostic criteria of myeloproliferative neoplasms	17
Patient outcomes improve when a molecular signature test guides treatment decision-making in rheumatoid arthritis	16
Efficient screening strategies for severe combined immunodeficiencies in newborns	16
The challenges and potential in developing microRNA associated with regeneration as biomarkers to improve prognostication for liver failure syndromes and hepatocellular carcinoma	15
Genomic determinants of biological aggressiveness and poor prognosis of pancreatic cancers: KRAS and beyond	15
Comprehensive genomic profiling: a public health system perspective	15
Regulation of biomarker analysis: what can be translated in the clinic?	14
Discovery of potential biomarkers for osteoporosis diagnosis by individual omics and multi-omics technologies	14
The association between normalized creatinine-to-cystatin C ratio and incident circadian syndrome in middle-aged and older adults: a national cohort study	14
Point-of-care isothermal nucleic acid amplification tests: progress and bottlenecks for extraction-free sample collection and preparation	14
Biomarkers of sleep-wake disturbance as predictors of cognitive decline and accelerated disease progression	13
Analytical validation of urine ALCAM ELISA as a test for lupus nephritis	13
KIM-1 and beyond: emerging biomarkers for adjuvant immunotherapy in clear cell renal cell carcinoma	13
Association between polymorphisms in TLR3 , TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil	13
Extracellular vesicles as diagnostic and prognostic biomarkers in non-small cell lung cancer	13
Molecular deciphering of melanoma: advances and challenges of neoadjuvant and perioperative treatment	13
Genomic profiling as an option for ovarian cancer diagnostics	13
Extracellular vesicles as source of biomarkers in hematological malignancies: looking towards clinical applications	13
Early diagnostics of fibromyalgia: an overview of the challenges and opportunities	12
Cytokines as biomarkers of Huntington’s disease progression	12
Urinary biomarkers for immunotherapy response in urothelial carcinoma: current status and future outlook	12
Cystic echinococcosis microRNAs as potential noninvasive biomarkers: current insights and upcoming perspective	12
Intraoperative detection of axillary metastasis of breast cancer using nucleic acid amplification methods: review of advantages and limitations	11
Guarding the genome: strategies for off-target detection and minimization in CRISPR/Cas9 system	11
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease	11
Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa	11
An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure	11
Association betweenCDH1methylation and esophageal cancer risk: a meta-analysis and bioinformatics study	11
The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery	11
Genetic-based diagnostics of Parkinson’s disease and other Parkinsonian syndromes	10
Prognostic biomarkers in melanoma: a 2023 update from clinical trials in different therapeutic scenarios	10
Diagnosing, treating and monitoring the inflammatory endotype in osteoarthritis clinical trials	10
MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review	10
Diagnostic approaches for dengue infection	10
Decoding pancreatic cancer: key risk factors across genetics and lifestyle	10
Unraveling the future: hot topics shaping molecular diagnostics today	10
Potential role of circulating miR-21 in the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis	9
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers	9

Comparative review of diagnostic techniques for DNA methylation analysis	9
COVID-19 diagnosis: lessons to learn and hints for preparedness	9
The association between blood sodium levels and survival in patients treated with immune checkpoint inhibitors	9
Transforming breast cancer care: the critical role of digital pathology and artificial intelligence in biomarker testing and risk stratification	9
hTERT rs2735940 polymorphism influences lung cancer risk and overall survival in lung cancer patients undergoing platinum-based doublet chemotherapy	9
From detection to action: new diagnostic insights into antifungal resistance	9
Bacterial respiratory infections in children: advances in diagnostic strategies	9
Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases	9
Role of liquid biopsy in genitourinary (GU) cancers	9
Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology	9
Recent developments in wearable & non-wearable point-of-care biosensors for cortisol detection	8
Noninvasive prenatal screening in southeast China: clinical application and accuracy evaluation	8
The role of fecal biomarkers in individuals with inflammatory bowel disease	8
Variants of KLF5 and KLF12 were related to endometrial cancer risk in the Chinese population	8
Exploring non-sputum biosignatures for tuberculosis triage and diagnosis in children living with HIV	8
Molecular determination of insect venom allergies	8
Advances in pediatric sepsis biomarkers - what have we learnt so far?	8
Highlighting and addressing barriers to widespread adaptation of HIV self-testing in the United States	8
How our molecular understanding of the pathogenesis of Mycobacterium ulcerans infection can improve diagnosis of Buruli ulcer	8
Saliva-based Hormone Diagnostics: advances, applications, and future perspectives	8
Challenges facing genetic diagnostics of Huntington’s disease: an update	8
Development and validation of a nomogram for the prediction of metabolic syndrome in polycystic ovary syndrome in a Chinese population	8
Association between NUDT17 polymorphisms and breast cancer risk	8
JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence	8
Global polymorphism of Plasmodium falciparum histidine rich proteins 2/3 and impact on malaria rapid diagnostic test detection: a systematic review and meta-analysis	8