OOIR: Observatory of International Research

Papers

(The TQCC of Expert Review of Molecular Diagnostics is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Do small RNAs have potential in disease diagnosis and treatment?	67
Cost analyses for malaria molecular diagnosis for research planners in India and beyond	62
Gene fusions in vascular tumors and their underlying molecular mechanisms	58
Alzheimer’s disease: a scoping review of biomarker research and development for effective disease diagnosis	51
Clinicopathological, etiological and molecular characteristics of intrahepatic cholangiocarcinoma subtypes classified by mucin production and immunohistochemical features	46
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer	33
Analytical validation of a novel multi-target blood-based test to detect hepatocellular carcinoma	33
Polygenic and Network-based studies in risk identification and demystification of cancer	32
Mild behavioral impairment and neurodegeneration: time for a biomarker-based assessment	30
Evolution and future of cervical cancer screening: from cytology to primary HPV testing and the impact of vaccination	29
Retrospective analysis of the risk factors associated with failure in obtaining effective noninvasive prenatal test results and pregnancy outcomes: a case-control study	28
Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer	28
Molecular point-of-care testing in the community pharmacy setting: current status and future prospects	25
Molecular charcterization of lung adenocarcinoma combining whole exome sequencing, copy number analysis and gene expression profiling	25
Evaluating tumor cell- and T cell-derived extracellular vesicles as potential biomarkers of cancer and immune cell competence	24
Harnessing the potential of genomic characterization of mutational profiles to improve early diagnosis of lung cancer	24
Nuclease activity: an exploitable biomarker in bacterial infections	24
Unlocking the power of biomarkers: transforming the diagnosis of acute respiratory distress syndrome	23
Recent updates in the development of molecular assays for the rapid identification and susceptibility testing of MRSA	23
Targeted RNA-sequencing for the evaluation of gene fusions in lung tumors: current status and future prospects	23
RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?	22
The MALAT1-breast cancer interplay: insights and implications	22
The current and future applications of in situ hybridization technologies in anatomical pathology	22
Enzymatic cross-linking of collagens in organ fibrosis – resolution and assessment	22
Functional proteomic analysis, a missing piece for understanding clonal evolution and cooperation in the tissue microecology	20

A novel anoikis-related signature predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma	20
Evaluation of molecular techniques to visceral leishmaniasis detection in asymptomatic patients: a systematic review	20
Clinical application of noninvasive prenatal testing in twin pregnancies: a single-center experience	19
Neuroimaging with PET/CT in chronic traumatic encephalopathy: what nuclear medicine can do to move the field forward	19
Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis	18
Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers	18
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease	18
Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma	18
Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: racial, ethnic, and geographical considerations	18
Genetic risk and gastric cancer: polygenic risk scores in population-based case-control study	17
Common markers of testicular Sertoli cells	17
Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma	17
The diagnostic accuracy of seven commercial molecular in vitro SARS-CoV-2 detection tests: a rapid meta-analysis	17
Molecular predictors of metastasis in patients with prostate cancer	16
Efficient screening strategies for severe combined immunodeficiencies in newborns	16
Early Identification of Fungal and Mycobacterium Infections in Pulmonary Granulomas Using Metagenomic Next-Generation Sequencing on Formalin fixation and paraffin embedding tissue	16
The clinical importance of high-sensitivity cardiac troponin measurements for risk prediction in non-cardiac surgery	16
The prognostic and diagnostic potential of kallikrein-related peptidases in ovarian cancer	16
Discovery of potential biomarkers for osteoporosis diagnosis by individual omics and multi-omics technologies	16
Optimization of time interval for the measurement of plasma lipids for cardiovascular disease risk assessment	15
Molecular diagnostic criteria of myeloproliferative neoplasms	15
Point-of-care isothermal nucleic acid amplification tests: progress and bottlenecks for extraction-free sample collection and preparation	15
Comprehensive genomic profiling: a public health system perspective	14
Genomic determinants of biological aggressiveness and poor prognosis of pancreatic cancers: KRAS and beyond	14
LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis	14
The challenges and potential in developing microRNA associated with regeneration as biomarkers to improve prognostication for liver failure syndromes and hepatocellular carcinoma	14
Biomarkers of sleep-wake disturbance as predictors of cognitive decline and accelerated disease progression	13
Patient outcomes improve when a molecular signature test guides treatment decision-making in rheumatoid arthritis	13
Association between polymorphisms in TLR3 , TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil	13
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease	13
Reviewing the occurrence of large genomic rearrangements in patients with inherited cancer predisposing syndromes: importance of a comprehensive molecular diagnosis	13
Cystic echinococcosis microRNAs as potential noninvasive biomarkers: current insights and upcoming perspective	13
Comparative evaluation of a dual-target real-time RT-PCR assay for COVID-19 diagnosis and assessment of performance in pooled saliva and nasopharyngeal swab samples	12
The role of molecular heterogeneity targeting resistance mechanisms to lung cancer therapies	12
Characteristics of circRNA and its approach as diagnostic tool in melanoma	12
Cytokines as biomarkers of Huntington’s disease progression	12
Early diagnostics of fibromyalgia: an overview of the challenges and opportunities	12
Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers	12
Extracellular vesicles as source of biomarkers in hematological malignancies: looking towards clinical applications	12
Analytical validation of urine ALCAM ELISA as a test for lupus nephritis	12
Faster infection diagnostics for intensive care unit (ICU) patients	11
Diagnostic approaches for dengue infection	11
Unraveling the future: hot topics shaping molecular diagnostics today	11
Quantitative versus qualitative estrogen and luteinizing hormone testing for personal fertility monitoring	11
Association betweenCDH1methylation and esophageal cancer risk: a meta-analysis and bioinformatics study	11
Prognostic biomarkers in melanoma: a 2023 update from clinical trials in different therapeutic scenarios	11
An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure	11
Potential role of circulating miR-21 in the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis	10
The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery	10
MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review	10

Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations	10
From detection to action: new diagnostic insights into antifungal resistance	10
Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa	10
Application of selected biosensor techniques in clinical diagnostics	10
COVID-19 diagnosis: lessons to learn and hints for preparedness	10
The association between blood sodium levels and survival in patients treated with immune checkpoint inhibitors	10
Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology	10
Decoding pancreatic cancer: key risk factors across genetics and lifestyle	10
Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors – A systematic review	10
Genetic-based diagnostics of Parkinson’s disease and other Parkinsonian syndromes	10
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers	10
Noninvasive prenatal screening in southeast China: clinical application and accuracy evaluation	9
Highlighting and addressing barriers to widespread adaptation of HIV self-testing in the United States	9
Association between NUDT17 polymorphisms and breast cancer risk	9
How our molecular understanding of the pathogenesis of Mycobacterium ulcerans infection can improve diagnosis of Buruli ulcer	9
JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence	9
Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers	9
Advances in pediatric sepsis biomarkers - what have we learnt so far?	9
Known biomarkers for monitoring pregnancy complications	9
The role of fecal biomarkers in individuals with inflammatory bowel disease	9
Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases	9
Recent developments in wearable & non-wearable point-of-care biosensors for cortisol detection	9
An updated review of the role of lncRNAs and their contribution in various molecular subtypes of breast cancer	9
Molecular determination of insect venom allergies	9
Determining the accuracy of next generation sequencing based copy number variation analysis in Hereditary Breast and Ovarian Cancer	8
Statistical determination of cancer biomarkers: moving forward clinically	8
CD44v6 acts as a directional responding factor in the process of transcoelomic metastasis from gastric carcinoma to Krukenberg tumor	8
How reliable are polygenic risk scores for risk prediction in patients with heart disease?	8
Recent advances in rapid antimicrobial susceptibility testing systems	8
Future potential of metagenomics in microbiology laboratories	8
Towards improved point-of-care (POC) testing for patients with suspected sepsis: POC tests for host biomarkers and possible microbial pathogens	8
Variants of KLF5 and KLF12 were related to endometrial cancer risk in the Chinese population	8
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers	8