Expert Review of Molecular Diagnostics

Article	Citations
LAMP Diagnostics at the Point-of-Care: Emerging Trends and Perspectives for the Developer Community	141
The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery	44
Advances in tests for colorectal cancer screening and diagnosis	43
Rapid lateral flow tests for the detection of SARS-CoV-2 neutralizing antibodies	42
The diagnostic and prognostic role of neutrophil-to-lymphocyte ratio in COVID-19: a systematic review and meta-analysis	40
Critical insight into recombinase polymerase amplification technology	38
Noninvasive detection of COPD and Lung Cancer through breath analysis using MOS Sensor array based e-nose	37
Developing multiplex ddPCR assays for SARS-CoV-2 detection based on probe mix and amplitude based multiplexing	34
Role of N6-methyladenosine modification in pathogenesis of ischemic stroke	32
Diagnosis for COVID-19: current status and future prospects	31
Enzymatic cross-linking of collagens in organ fibrosis – resolution and assessment	26
Ultrasensitive circulating tumor DNA analysis enables precision medicine: experimental workflow considerations	25
Emerging circulating MiRNAs and LncRNAs in upper gastrointestinal cancers	25
Liquid biopsy in head and neck squamous cell carcinoma: circulating tumor cells, circulating tumor DNA, and exosomes	24
Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma	23
An overview of using fungal DNA for the diagnosis of invasive mycoses	23
Antimicrobial resistance prediction in Neisseria gonorrhoeae: current status and future prospects	23
Metabolomics-based predictive biomarkers of radiation injury and countermeasure efficacy: current status and future perspectives	22
Saliva as a sample type for SARS-CoV-2 detection: implementation successes and opportunities around the globe	22
Advances in RT-LAMP for COVID-19 testing and diagnosis	22
Liquid biopsy from research to clinical practice: focus on non-small cell lung cancer	22
Blood-based traumatic brain injury biomarkers – Clinical utilities and regulatory pathways in the United States, Europe and Canada	22
A review on current diagnostic techniques for COVID-19	22
Nanomaterial-based Optical and Electrochemical Biosensors for Amyloid beta and Tau: Potential for early diagnosis of Alzheimer’s Disease	22
Aptamer-based sensing of breast cancer biomarkers: a comprehensive review of analytical figures of merit	22

Circulating tumor cell clusters: Insights into tumour dissemination and metastasis	21
Concentration of cell-free DNA in different tumor types	21
Predictive biomarkers for systemic therapy of hepatocellular carcinoma	20
Advances in gold nanoparticle technology as a tool for diagnostics and treatment of cancer	19
Performance comparison of the Cobas® Liat® and Cepheid® GeneXpert® systems on SARS-CoV-2 detection in nasopharyngeal swab and posterior oropharyngeal saliva	19
RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?	19
A review on human body fluids for the diagnosis of viral infections: scope for rapid detection of COVID-19	19
Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors – A systematic review	18
dPCR application in liquid biopsies: divide and conquer	18
Human tear fluid analysis for clinical applications: progress and prospects	18
Emerging Role of Extracellular Vesicles in Biomarking the Gastrointestinal Diseases	17
Recent advances in the diagnosis monkeypox: implications for public health	17
Tumor treating fields: a comprehensive overview of the underlying molecular mechanism	17
Diagnostic and Prognostic Significance of Dysregulated Expression of Circular RNAs in Osteosarcoma	17
Mid-regional pro-adrenomedullin as a supplementary tool to clinical parameters in cases of suspicion of infection in the emergency department	16
Potential of CRISPR/Cas system in the diagnosis of COVID-19 infection	16
Circulating microRNA biomarkers in melanoma and non-melanoma skin cancer	16
A profile of the binx health io® molecular point-of-care test for chlamydia and gonorrhea in women and men	16
Future potential of metagenomics in microbiology laboratories	16
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer	16
Dysregulation of lncRNA-H19 in cardiometabolic diseases and the molecular mechanism involved : a systematic review	15
MicroRNA-217: a therapeutic and diagnostic tumor marker	15
Quantifying SARS-CoV-2 viral load: current status and future prospects	15
Improving laboratory diagnostics in myasthenia gravis	15
Brain tumors and circulating micrornas: a systematic review and diagnostic meta-analysis	15
Exploring the real-world effect of the SARS-CoV-2 pandemic on the molecular diagnostics for cancer patients and high-risk individuals	15
Molecular charcterization of lung adenocarcinoma combining whole exome sequencing, copy number analysis and gene expression profiling	15
Application of selected biosensor techniques in clinical diagnostics	15
The importance of genomic analysis in cracking the coronavirus pandemic	14
Identification of the candidate lncRNA biomarkers for acute kidney injury: a systematic review and meta-analysis	14
Noninvasive prenatal screening for fetal sex chromosome aneuploidies	14
Recent advances in the diagnosis of COVID-19: a bird’s eye view	14
Research tests for the diagnosis of tuberculosis infection	14
Quantitative versus qualitative estrogen and luteinizing hormone testing for personal fertility monitoring	14
Applications of the CRISPR-Cas system for infectious disease diagnostics	13
The clinical application of metagenomic next-generation sequencing for detecting pathogens in bronchoalveolar lavage fluid: case reports and literature review	13
True or false: what are the factors that influence COVID-19 diagnosis by RT-qPCR?	13
The diagnostic accuracy of seven commercial molecular in vitro SARS-CoV-2 detection tests: a rapid meta-analysis	13
Oral Potentially Malignant Disorders (OPMD): What is the clinical utility of dysplasia grade?	13
Diagnostic accuracy of cerebrospinal fluid and serum-isolated extracellular vesicles for glioblastoma: a systematic review and meta-analysis	13
Common markers of testicular Sertoli cells	13
Impact of non-antibiotic drugs on the human intestinal microbiome	13
Viral metagenomic sequencing in the diagnosis of meningoencephalitis: a review of technical advances and diagnostic yield	12
Optimizing testing regimes for the detection of COVID-19 in children and older adults	12
Cell-free DNA as a potential biomarker for preeclampsia	12
microRNAs as novel diagnostic biomarkers in endometriosis patients: a systematic review and meta-analysis	12
Point-of-care COVID-19 testing in the emergency department: current status and future prospects	12
Spatial profiling technologies and applications for brain cancers	12
An update on current and novel molecular diagnostics for the diagnosis of invasive fungal infections	11
ASSURED-SQVM diagnostics for COVID-19: addressing the why, when, where, who, what and how of testing	11

Unveiling the underpinnings of various non-conventional ELISA variants: a review article	11
Rapid metagenomics for diagnosis of bloodstream and respiratory tract nosocomial infections: current status and future prospects	11
Salivary biomarkers associated with obstructive sleep apnea: a systematic review	10
Current and future strategies for diagnostic and management of obstructive sleep apnea	10
Assessing our approach to diagnosing Fibromyalgia	10
Construction of a 5-methylcytosine-Related Molecular Signature to Inform the Prognosis and Immunotherapy of Lung Squamous Cell Carcinoma	10
Radiomics and theranostics with molecular and metabolic probes in prostate cancer: toward a personalized approach	10
Advancing cervical cancer diagnosis and screening with spectroscopy and machine learning	10
Utility of droplet digital PCR and NGS-based CNV clinical assays in hearing loss diagnostics: current status and future prospects	10
Point-of-care testing for viral-associated pulmonary aspergillosis	10
Highly sensitive droplet digital PCR-based diagnostics for the surveillance of malaria vector populations in low transmission and incipient resistance settings	9
Current and emerging biomarkers for ulcerative colitis	9
The detrimental impact of elevated Ferritin to Iron ratio on in-hospital prognosis of patients with COVID-19	9
Updates in diagnosing polycystic ovary syndrome-related infertility	9
Recent advances in rapid antimicrobial susceptibility testing systems	9
Neuroimaging with PET/CT in chronic traumatic encephalopathy: what nuclear medicine can do to move the field forward	9
Beyond the Usual Suspects: Expanding on Mutations and Detection for Familial Hypercholesterolemia	9
Brain exosomes as minuscule information hub for Autism Spectrum Disorder	9
The relationship between positivity for COVID-19 RT-PCR and symptoms, clinical findings, and mortality in Turkey	9
Investigation of LOY in Prostate, Pancreatic, and Colorectal Cancers in males: A case–control study	9
Nuclease activity: an exploitable biomarker in bacterial infections	9
Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: racial, ethnic, and geographical considerations	9
Using lipocalin as a prognostic biomarker in acute kidney injury	9
At-home coronavirus testing: the next game-changer?	9
The potential diagnostic value of extracellular vesicle miRNA for human non-small cell lung cancer: a systematic review and meta-analysis	9
Diagnostic value of monocyte to high-density lipoprotein ratio in acute aortic dissection in a Chinese han population	9
The prenatal exome – a door to prenatal diagnostics?	9
A computational prognostic model of lncRNA signature for clear cell renal cell carcinoma with genome instability	8
Insight into diagnosis of female genital tuberculosis	8
Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortality	8
Toward an individualized determination of dialysis adequacy: a narrative review with special emphasis on incremental hemodialysis	8
Polygenic and Network-based studies in risk identification and demystification of cancer	8
Liquid biopsy derived circulating tumor cells and circulating tumor DNA as novel biomarkers in hepatocellular carcinoma	8
Molecular imaging in immuno-oncology: current status and translational perspectives	8
Challenges in diagnosing hydatidiform moles: a review of promising molecular biomarkers	8
Advances in the diagnosis of autoimmune diseases based on citrullinated peptides/proteins	8
Protein array-based companion diagnostics in precision medicine	8
A systematic review and meta-analysis on the relative and attributable risk of Helicobacter pylori infection and cardia and non-cardia gastric cancer	8
Screening for ROS1 fusions in patients with advanced non-small cell lung carcinomas using the VENTANA ROS1 (SP384) Rabbit Monoclonal Primary Antibody	8
Clinical utility of therapy selection informed by predicted nonresponse to tumor necrosis factor-ɑ inhibitors: an analysis from the Study to Accelerate Information of Molecular Signatures (AIMS) in rh	8
A profile of the FDA-approved and CE/IVD-marked AptimaMycoplasma genitaliumassay (Hologic) and key priorities in the management ofM. genitaliuminfections	8
Application of perovskites in bioimaging: the state-of-the-art and future developments	7
Gene fusions in vascular tumors and their underlying molecular mechanisms	7
Genetic variations as molecular diagnostic factors for idiopathic male infertility: current knowledge and future perspectives	7
Monitoring immunomodulation in patients with sepsis	7
Advances in tuberculous meningitis diagnosis	7
Evaluation of the Onclarity HPV assay on the high-throughput COR system	7
Diagnostic utility of rapid sequencing in critically ill infants: a systematic review and meta-analysis	7
Virtual tissue staining in pathology using machine learning	7
Comparative evaluation of a dual-target real-time RT-PCR assay for COVID-19 diagnosis and assessment of performance in pooled saliva and nasopharyngeal swab samples	7
Evaluation of the performance of the BD MAX MDR-TB test in the diagnosis of Mycobacterium tuberculosis complex in extrapulmonary and pulmonary samples	7
Early predictive value of circulating biomarkers for sorafenib in advanced hepatocellular carcinoma	7
Next-generation sequencing for the diagnosis of hepatitis B: current status and future prospects	7
Recent developments in wearable & non-wearable point-of-care biosensors for cortisol detection	7
The current and future applications of in situ hybridization technologies in anatomical pathology	7
Circulating tumor cells as prognostic biomarkers in breast cancer: current status and future prospects	7
The role of molecular heterogeneity targeting resistance mechanisms to lung cancer therapies	7
Alpha-defensin does not provide additional benefit over leukocyte esterase in the diagnosis of periprosthetic joint infection	7
Molecular techniques for the genomic viral RNA detection of West Nile, Dengue, Zika and Chikungunya arboviruses: a narrative review	7
Predicting wet age-related macular degeneration (AMD) using DARC (detecting apoptosing retinal cells) AI (artificial intelligence) technology	7
Villin expression in human tumors: a tissue microarray study on 14,398 tumors	6
Saliva diagnostics: emerging techniques and biomarkers for salivaomics in cancer detection	6
Point of care molecular and antigen detection tests for COVID-19: current status and future prospects	6
Nonalcoholic fatty liver disease: use of diagnostic biomarkers and modalities in clinical practice	6
Retrospective analysis of the risk factors associated with failure in obtaining effective noninvasive prenatal test results and pregnancy outcomes: a case-control study	6
Impact of the new European Union In Vitro Diagnostics Regulation on the practice of hospital diagnostic laboratories	6
Diagnostic and predictive value of liquid biopsy-derived exosome miR-21 for breast cancer: a systematic review and meta-analysis	6
Loop-mediated isothermal amplification for Candida species surveillance in under-resourced setting: a review of evidence	6
α-synuclein as an emerging pathophysiological biomarker of Alzheimer’s disease	6
Monitoring hepatitis B by using point-of-care testing: biomarkers, current technologies, and perspectives	6
Diagnostic techniques in HPV infections and the need to implement them in plantar lesions: A systematic review	6
Mutations of key driver genes in gastric cancer metastasis risk: a systematic review and meta-analysis	6
Gastrin-releasing peptide receptor agonists and antagonists for molecular imaging of breast and prostate cancer: from pre-clinical studies to translational perspectives	6
Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers	6
Analytical validation of a novel multi-target blood-based test to detect hepatocellular carcinoma	6
Diagnosis of extrapulmonary tuberculosis by GeneXpert MTB/RIF Ultra assay	6
Dual agonist–antagonist effect of ulipristal acetate in human endometrium and myometrium	5
An update on companion and complementary diagnostic assays for PD-1/PD-L1 checkpoint inhibitors in NSCLC	5
Emerging prognostic biomarkers in advanced cutaneous melanoma: a literature update	5
The potential for rapid antigen testing for mucormycosis in the context of COVID-19	5

Anti-citrullinated protein antibodies as biomarkers in rheumatoid arthritis	5
Genomic characterization reveals potential biomarkers in nasopharyngeal carcinoma patients with relapse	5
Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers	5
The MALAT1-breast cancer interplay: insights and implications	5
An updated review of the role of lncRNAs and their contribution in various molecular subtypes of breast cancer	5
Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers	5
The game changer: UCH-L1 and GFAP-based blood test as the first marketed in vitro diagnostic test for mild traumatic brain injury	5
Heart failure risk estimation based on novel biomarkers	5
The association of brain-derived neurotrophic factor with the diagnosis and treatment response in depression	5
Diagnostic and prognostic value of long noncoding RNAs in sepsis: a systematic review and meta-analysis	5
A stroll through the present and future of testicular germ cell tumour biomarkers	5
How to effectively utilize imaging in disease-modifying treatments for osteoarthritis clinical trials: the radiologist’s perspective	5
The biomolecular corona of extracellular nanoparticles holds new promises for advancing clinical molecular diagnostics	5
Alzheimer’s disease: a scoping review of biomarker research and development for effective disease diagnosis	5
Epigenetic signatures in gastric cancer: current knowledge and future perspectives	5
Rapid diagnostic tests in the management of pneumonia	5
Blood-based biomarkers of chronic inflammation	5
Multitarget fluorescence in situ hybridization diagnostic applications in solid and hematological tumors	5
Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry	5
Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis	5
Molecular sequencing technologies in the diagnosis and management of prosthetic joint infections	5
Known biomarkers for monitoring pregnancy complications	4
Clinical application of circulating tumor DNA in metastatic cancers	4
Diagnostic accuracy of CRISPR technology for detecting SARS-CoV-2: a systematic review and meta-analysis	4
Creating standards for liquid biopsies: the BLOODPAC experience	4
Discovery of potential biomarkers for osteoporosis diagnosis by individual omics and multi-omics technologies	4
Reprogramming of lipid metabolism in hepatocellular carcinoma resulting in downregulation of phosphatidylcholines used as potential markers for diagnosis and prediction	4
Fetal screening and whole genome sequencing: where are the limits?	4
The significance of tissue-agnostic biomarkers in solid tumors: the more the merrier?	4
The diagnostic significance of CDH17-positive circulating tumor cells in patients with colorectal cancer	4
An update on our ability to monitor castration-resistant prostate cancer dynamics with cell-free DNA	4
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers	4
Diagnostic significance of heart-type fatty acid-binding protein as a potential biomarker to predict the mortality rate of patients with sepsis: a systematic review and meta-analysis	4
PCR diagnostic platforms for non- Aspergillus mold infections: ready for routine implementation in the clinic?	4
Diagnostic profile of the AmplideX Fragile X Dx and Carrier Screen Kit for diagnosis and screening of fragile X syndrome and other FMR1-related disorders	4
An insight into clinical and laboratory detections for screening and diagnosis of cervical cancer	4
Updates on the profile of GenMark’s ePlex blood culture identification fungal pathogen panel	4
The value of companion diagnostics in oncology drug development	4
Impact of the COVID-19 pandemic on Molecular Diagnostics	4
Molecular determination of insect venom allergies	4
Future potential of Rapid Acceleration of Diagnostics (RADx Tech) in molecular diagnostics	4
Analytical and clinical validation of an RNA sequencing-based assay for quantitative, accurate evaluation of a molecular signature response classifier in rheumatoid arthritis	4
Noninvasive imaging assessment of portal hypertension: where are we now and where does the future lie?	4
Prognostic value of baculoviral IAP repeat containing 5 expression as a new biomarker in lung adenocarcinoma: a meta-analysis	4
Values of liquid biopsy in early detection of cancer: results from meta-analysis	4
The prognostic and diagnostic potential of kallikrein-related peptidases in ovarian cancer	4
The clinical importance of high-sensitivity cardiac troponin measurements for risk prediction in non-cardiac surgery	4
Clinical value of identifying genes that inhibit hepatocellular carcinomas	3
Promotor methylation in ocular surface squamous neoplasia development: epigenetics implications in molecular diagnosis	3
Pathology-supported genetic testing for the application of breast cancer pharmacodiagnostics: family counselling, lifestyle adjustments and change of medication	3
Molecular biomarkers of diffuse axonal injury: recent advances and future perspectives	3
Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa	3
Clinical utility of the 'Determine HBsAg' Point-of-Care Test for Diagnosis of Hepatitis B Surface Antigen in Africa	3
Prognostic Value of lncRNA NEAT1 as a New Biomarker in Digestive System Tumors: a Systematic Study and Meta-analysis	3
Patient outcomes improve when a molecular signature test guides treatment decision-making in rheumatoid arthritis	3
Relationship between diagnostic accuracy of microRNAs for NSCLC and number of combined microRNAs: an overview with meta-analysis	3
Evaluation of molecular techniques to visceral leishmaniasis detection in asymptomatic patients: a systematic review	3
The impact of the COVID-19 pandemic on addressing common barriers to pharmacy-based point-of-care testing	3
Evaluating tumor cell- and T cell-derived extracellular vesicles as potential biomarkers of cancer and immune cell competence	3
Circulating biomarkers of response to immunotherapy and immune-related adverse events	3
Transcription activator-like effector nuclease (TALEN) as a promising diagnostic approach for COVID-19	3
Genetic and epigenetic studies of opioid abuse disorder – the potential for future diagnostics	3
Combined exome analysis and exome depth assessment achieve a high diagnostic yield in an epilepsy case series, revealing significant genomic heterogeneity and novel mechanisms	3
Enhanced mitochondrial genome analysis: bioinformatic and long-read sequencing advances and their diagnostic implications	3
An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure	3
SSR4 as a prognostic biomarker and related with immune infiltration cells in colon adenocarcinoma	3
Analytical validation of urine ALCAM ELISA as a test for lupus nephritis	3
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease	3