Expert Review of Molecular Diagnostics

Article	Citations
Real-time RT-PCR in COVID-19 detection: issues affecting the results	823
LAMP Diagnostics at the Point-of-Care: Emerging Trends and Perspectives for the Developer Community	100
Cystatin C as a biomarker of chronic kidney disease: latest developments	54
Saliva as a diagnostic tool for dental caries, periodontal disease and cancer: is there a need for more biomarkers?	42
The diagnostic methods in the COVID-19 pandemic, today and in the future	39
Spectroscopy as a tool for detection and monitoring of Coronavirus (COVID-19)	38
The diagnostic and prognostic role of neutrophil-to-lymphocyte ratio in COVID-19: a systematic review and meta-analysis	36
Rapid lateral flow tests for the detection of SARS-CoV-2 neutralizing antibodies	34
Developing multiplex ddPCR assays for SARS-CoV-2 detection based on probe mix and amplitude based multiplexing	31
Diagnosis for COVID-19: current status and future prospects	29
A CNN-aided method to predict glaucoma progression using DARC (Detection of Apoptosing Retinal Cells)	28
Advances in tests for colorectal cancer screening and diagnosis	27
Noninvasive detection of COPD and Lung Cancer through breath analysis using MOS Sensor array based e-nose	27
Role of N6-methyladenosine modification in pathogenesis of ischemic stroke	25
The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery	24
Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome	22
Emerging circulating MiRNAs and LncRNAs in upper gastrointestinal cancers	22
Urine as a biological modality for colorectal cancer detection	22
A review on current diagnostic techniques for COVID-19	21
Critical insight into recombinase polymerase amplification technology	21
Ultrasensitive circulating tumor DNA analysis enables precision medicine: experimental workflow considerations	20
Enzymatic cross-linking of collagens in organ fibrosis – resolution and assessment	20
Point-by-Point Progress: Gonorrhea Point of Care Tests	20
Alpha-gal syndrome: challenges to understanding sensitization and clinical reactions to alpha-gal	20
Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma	19

Concentration of cell-free DNA in different tumor types	19
Nanomaterial-based Optical and Electrochemical Biosensors for Amyloid beta and Tau: Potential for early diagnosis of Alzheimer’s Disease	18
Aptamer-based sensing of breast cancer biomarkers: a comprehensive review of analytical figures of merit	18
Common mutations of interest in the diagnosis of amyotrophic lateral sclerosis: how common are common mutations in ALS genes?	18
Saliva as a sample type for SARS-CoV-2 detection: implementation successes and opportunities around the globe	18
Metabolomics-based predictive biomarkers of radiation injury and countermeasure efficacy: current status and future perspectives	18
Blood-based traumatic brain injury biomarkers – Clinical utilities and regulatory pathways in the United States, Europe and Canada	18
Liquid biopsy from research to clinical practice: focus on non-small cell lung cancer	18
Circulating tumor cell clusters: Insights into tumour dissemination and metastasis	17
Antimicrobial resistance prediction in Neisseria gonorrhoeae: current status and future prospects	17
Challenges in the clinical implementation of precision medicine companion diagnostics	17
Diagnostic and Prognostic Significance of Dysregulated Expression of Circular RNAs in Osteosarcoma	17
A review on human body fluids for the diagnosis of viral infections: scope for rapid detection of COVID-19	17
An overview of using fungal DNA for the diagnosis of invasive mycoses	17
Performance comparison of the Cobas® Liat® and Cepheid® GeneXpert® systems on SARS-CoV-2 detection in nasopharyngeal swab and posterior oropharyngeal saliva	16
Point-of-care diagnostics for invasive aspergillosis: nearing the finish line	16
Predictive biomarkers for systemic therapy of hepatocellular carcinoma	16
RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?	16
Emerging Role of Extracellular Vesicles in Biomarking the Gastrointestinal Diseases	16
Circular RNAs: novel diagnostic and therapeutic targets for ischemic stroke	16
Advances in gold nanoparticle technology as a tool for diagnostics and treatment of cancer	16
Exploring the real-world effect of the SARS-CoV-2 pandemic on the molecular diagnostics for cancer patients and high-risk individuals	15
Liquid biopsy in head and neck squamous cell carcinoma: circulating tumor cells, circulating tumor DNA, and exosomes	15
dPCR application in liquid biopsies: divide and conquer	14
Mid-regional pro-adrenomedullin as a supplementary tool to clinical parameters in cases of suspicion of infection in the emergency department	14
Recent advances in the diagnosis of COVID-19: a bird’s eye view	14
Evolution of approaches to identify melanoma missing heritability	14
Recent advances in the diagnosis monkeypox: implications for public health	14
New and developing diagnostic platforms for COVID-19: A systematic review	14
Clinical genomics and contextualizing genome variation in the diagnostic laboratory	13
Potential of CRISPR/Cas system in the diagnosis of COVID-19 infection	13
Impact of non-antibiotic drugs on the human intestinal microbiome	13
The importance of genomic analysis in cracking the coronavirus pandemic	13
Advances in quantitative immunohistochemistry and their contribution to breast cancer	13
Dysregulation of lncRNA-H19 in cardiometabolic diseases and the molecular mechanism involved : a systematic review	13
Molecular charcterization of lung adenocarcinoma combining whole exome sequencing, copy number analysis and gene expression profiling	13
Cervical cancer risk profiling: molecular biomarkers predicting the outcome of hrHPV infection	13
Human tear fluid analysis for clinical applications: progress and prospects	13
Improving laboratory diagnostics in myasthenia gravis	13
Clinical relevance ofliquid biopsyin breast cancer: update in 2020	12
Tumor treating fields: a comprehensive overview of the underlying molecular mechanism	12
Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors – A systematic review	12
Applications of the CRISPR-Cas system for infectious disease diagnostics	12
Optimizing testing regimes for the detection of COVID-19 in children and older adults	12
Circulating microRNA biomarkers in melanoma and non-melanoma skin cancer	12
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer	12
Point-of-care COVID-19 testing in the emergency department: current status and future prospects	11
Update on urine as a biomarker in cancer: a necessary review of an old story	11
A profile of the binx health io® molecular point-of-care test for chlamydia and gonorrhea in women and men	11
An overview of current and emerging diagnostic, staging and prognostic markers for prostate cancer	11

Improving genetic diagnostics of skeletal muscle channelopathies	11
The diagnostic accuracy of seven commercial molecular in vitro SARS-CoV-2 detection tests: a rapid meta-analysis	11
MicroRNA-217: a therapeutic and diagnostic tumor marker	11
Spatial profiling technologies and applications for brain cancers	11
Noninvasive prenatal screening for fetal sex chromosome aneuploidies	11
Quantifying SARS-CoV-2 viral load: current status and future prospects	11
Identification of the candidate lncRNA biomarkers for acute kidney injury: a systematic review and meta-analysis	11
microRNAs as novel diagnostic biomarkers in endometriosis patients: a systematic review and meta-analysis	11
Quantitative versus qualitative estrogen and luteinizing hormone testing for personal fertility monitoring	11
Liquid biopsy markers for stroke diagnosis	10
Salivary biomarkers associated with obstructive sleep apnea: a systematic review	10
Future potential of metagenomics in microbiology laboratories	10
Viral metagenomic sequencing in the diagnosis of meningoencephalitis: a review of technical advances and diagnostic yield	10
Application of selected biosensor techniques in clinical diagnostics	10
Oral Potentially Malignant Disorders (OPMD): What is the clinical utility of dysplasia grade?	10
Assessing our approach to diagnosing Fibromyalgia	10
Rapid metagenomics for diagnosis of bloodstream and respiratory tract nosocomial infections: current status and future prospects	10
Advances in RT-LAMP for COVID-19 testing and diagnosis	10
Brain tumors and circulating micrornas: a systematic review and diagnostic meta-analysis	10
True or false: what are the factors that influence COVID-19 diagnosis by RT-qPCR?	10
Construction of a 5-methylcytosine-Related Molecular Signature to Inform the Prognosis and Immunotherapy of Lung Squamous Cell Carcinoma	10
Common markers of testicular Sertoli cells	10
Role of artificial intelligence and vibrational spectroscopy in cancer diagnostics	10
Diagnostic accuracy of cerebrospinal fluid and serum-isolated extracellular vesicles for glioblastoma: a systematic review and meta-analysis	9
Loop-mediated isothermal amplification methods for diagnosis of visceral leishmaniasis (kala-azar) – a systematic review	9
Highly sensitive droplet digital PCR-based diagnostics for the surveillance of malaria vector populations in low transmission and incipient resistance settings	9
The relationship between positivity for COVID-19 RT-PCR and symptoms, clinical findings, and mortality in Turkey	9
At-home coronavirus testing: the next game-changer?	9
ASSURED-SQVM diagnostics for COVID-19: addressing the why, when, where, who, what and how of testing	9
Advances in the clinical use of collagen as biomarker of liver fibrosis	9
Radiomics and theranostics with molecular and metabolic probes in prostate cancer: toward a personalized approach	9
Current and future strategies for diagnostic and management of obstructive sleep apnea	9
Cell-free DNA as a potential biomarker for preeclampsia	8
Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortality	8
Molecular imaging in immuno-oncology: current status and translational perspectives	8
Utility of droplet digital PCR and NGS-based CNV clinical assays in hearing loss diagnostics: current status and future prospects	8
Update on molecular companion diagnostics - a future in personalized medicine beyond Sanger sequencing	8
Beyond the Usual Suspects: Expanding on Mutations and Detection for Familial Hypercholesterolemia	8
Investigation of LOY in Prostate, Pancreatic, and Colorectal Cancers in males: A case–control study	8
Companion and complementary diagnostics: an important treatment decision tool in precision medicine	8
The potential of circulating exosomal RNA biomarkers in cancer	8
A computational prognostic model of lncRNA signature for clear cell renal cell carcinoma with genome instability	7
The detrimental impact of elevated Ferritin to Iron ratio on in-hospital prognosis of patients with COVID-19	7
Screening for ROS1 fusions in patients with advanced non-small cell lung carcinomas using the VENTANA ROS1 (SP384) Rabbit Monoclonal Primary Antibody	7
The potential diagnostic value of extracellular vesicle miRNA for human non-small cell lung cancer: a systematic review and meta-analysis	7
Polygenic and Network-based studies in risk identification and demystification of cancer	7
Comparative evaluation of a dual-target real-time RT-PCR assay for COVID-19 diagnosis and assessment of performance in pooled saliva and nasopharyngeal swab samples	7
Circulating tumor cells as prognostic biomarkers in breast cancer: current status and future prospects	7
Insight into diagnosis of female genital tuberculosis	7
Bladder neoplasms and NF-κB: an unfathomed association	7
Alpha-defensin does not provide additional benefit over leukocyte esterase in the diagnosis of periprosthetic joint infection	7
Brain exosomes as minuscule information hub for Autism Spectrum Disorder	7
Incorporating traditional and emerging biomarkers in the clinical management of metastatic colorectal cancer: an update	7
Gene fusions in vascular tumors and their underlying molecular mechanisms	7
The prenatal exome – a door to prenatal diagnostics?	7
Review of current status of molecular diagnosis and characterization of monogenic diabetes mellitus: a focus on next-generation sequencing	7
Using lipocalin as a prognostic biomarker in acute kidney injury	7
Molecular analysis of the destruction of articular joint tissues by Raman spectroscopy	7
Unveiling the underpinnings of various non-conventional ELISA variants: a review article	7
Food allergy severity predictions based on cellular in vitro tests	7
Neuroimaging with PET/CT in chronic traumatic encephalopathy: what nuclear medicine can do to move the field forward	7
Advances in the diagnosis of autoimmune diseases based on citrullinated peptides/proteins	7
A profile of the FDA-approved and CE/IVD-marked AptimaMycoplasma genitaliumassay (Hologic) and key priorities in the management ofM. genitaliuminfections	7
Predicting wet age-related macular degeneration (AMD) using DARC (detecting apoptosing retinal cells) AI (artificial intelligence) technology	6
Nonalcoholic fatty liver disease: use of diagnostic biomarkers and modalities in clinical practice	6
Toward an individualized determination of dialysis adequacy: a narrative review with special emphasis on incremental hemodialysis	6
Protein array-based companion diagnostics in precision medicine	6
Gastrin-releasing peptide receptor agonists and antagonists for molecular imaging of breast and prostate cancer: from pre-clinical studies to translational perspectives	6
The value of biomarker-guided antibiotic therapy	6
Emerging biomarkers in chronic lung allograft dysfunction	6
The clinical application of metagenomic next-generation sequencing for detecting pathogens in bronchoalveolar lavage fluid: case reports and literature review	6
Clinical utility of therapy selection informed by predicted nonresponse to tumor necrosis factor-ɑ inhibitors: an analysis from the Study to Accelerate Information of Molecular Signatures (AIMS) in rh	6
Evaluation of the performance of the BD MAX MDR-TB test in the diagnosis of Mycobacterium tuberculosis complex in extrapulmonary and pulmonary samples	6
Next-generation sequencing for the diagnosis of hepatitis B: current status and future prospects	6
Recent advances in rapid antimicrobial susceptibility testing systems	6
Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: racial, ethnic, and geographical considerations	6
Application of perovskites in bioimaging: the state-of-the-art and future developments	6
Nuclease activity: an exploitable biomarker in bacterial infections	6
Diagnostic techniques in HPV infections and the need to implement them in plantar lesions: A systematic review	6
Liquid biopsy derived circulating tumor cells and circulating tumor DNA as novel biomarkers in hepatocellular carcinoma	6

Infrared analyzers for the measurement of breastmilk macronutrient content in the clinical setting	6
Evaluation of the Onclarity HPV assay on the high-throughput COR system	6
Point of care molecular and antigen detection tests for COVID-19: current status and future prospects	5
Molecular techniques for the genomic viral RNA detection of West Nile, Dengue, Zika and Chikungunya arboviruses: a narrative review	5
Endocrine fibroblast growth factors as potential biomarkers for chronic kidney disease	5
Heart failure risk estimation based on novel biomarkers	5
The current and future applications of in situ hybridization technologies in anatomical pathology	5
Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers	5
An evaluation of liposome-based diagnostics of pulmonary and extrapulmonary tuberculosis	5
Advances in tissue-based imaging: impact on oncology research and clinical practice	5
Loop-mediated isothermal amplification for Candida species surveillance in under-resourced setting: a review of evidence	5
Diagnostic value of monocyte to high-density lipoprotein ratio in acute aortic dissection in a Chinese han population	5
Is there a role for microRNAs in epilepsy diagnostics?	5
An updated review of the role of lncRNAs and their contribution in various molecular subtypes of breast cancer	5
Retrospective analysis of the risk factors associated with failure in obtaining effective noninvasive prenatal test results and pregnancy outcomes: a case-control study	5
Alzheimer’s disease: a scoping review of biomarker research and development for effective disease diagnosis	5
Early predictive value of circulating biomarkers for sorafenib in advanced hepatocellular carcinoma	5
Genomic characterization reveals potential biomarkers in nasopharyngeal carcinoma patients with relapse	5
Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry	5
Monitoring immunomodulation in patients with sepsis	5
Updates in diagnosing polycystic ovary syndrome-related infertility	5
Molecular sequencing technologies in the diagnosis and management of prosthetic joint infections	5
Dual agonist–antagonist effect of ulipristal acetate in human endometrium and myometrium	5
Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers	4
α-synuclein as an emerging pathophysiological biomarker of Alzheimer’s disease	4
Diagnostic value of circulating lncRNAs as biomarkers of digestive system cancers: A systematic review and meta-analysis	4
Monitoring hepatitis B by using point-of-care testing: biomarkers, current technologies, and perspectives	4
Genetic variations as molecular diagnostic factors for idiopathic male infertility: current knowledge and future perspectives	4
The role of molecular heterogeneity targeting resistance mechanisms to lung cancer therapies	4
Saliva diagnostics: emerging techniques and biomarkers for salivaomics in cancer detection	4
Fetal screening and whole genome sequencing: where are the limits?	4
An update on our ability to monitor castration-resistant prostate cancer dynamics with cell-free DNA	4
Future potential of Rapid Acceleration of Diagnostics (RADx Tech) in molecular diagnostics	4
Analytical and clinical validation of an RNA sequencing-based assay for quantitative, accurate evaluation of a molecular signature response classifier in rheumatoid arthritis	4
Analytical validation of a novel multi-target blood-based test to detect hepatocellular carcinoma	4
An update on companion and complementary diagnostic assays for PD-1/PD-L1 checkpoint inhibitors in NSCLC	4
Advancing cervical cancer diagnosis and screening with spectroscopy and machine learning	4
Prognostic value of baculoviral IAP repeat containing 5 expression as a new biomarker in lung adenocarcinoma: a meta-analysis	4
Values of liquid biopsy in early detection of cancer: results from meta-analysis	4
Diagnostic utility of rapid sequencing in critically ill infants: a systematic review and meta-analysis	4
Virtual tissue staining in pathology using machine learning	4
Genetic testing for the clinician in prostate cancer	4
Impact of the new European Union In Vitro Diagnostics Regulation on the practice of hospital diagnostic laboratories	4
Research tests for the diagnosis of tuberculosis infection	4
Advances in tuberculous meningitis diagnosis	4
Diagnostic and prognostic value of long noncoding RNAs in sepsis: a systematic review and meta-analysis	3
Impact of the COVID-19 pandemic on Molecular Diagnostics	3
Enumeration and molecular characterization of circulating tumor cells as an innovative tool for companion diagnostics in breast cancer	3
Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis	3
How to effectively utilize imaging in disease-modifying treatments for osteoarthritis clinical trials: the radiologist’s perspective	3
Comparative performance of two commercial sample-to-result systems for hepatitis C virus quantitation and genotyping	3
Diagnostic accuracy of CRISPR technology for detecting SARS-CoV-2: a systematic review and meta-analysis	3
The association of brain-derived neurotrophic factor with the diagnosis and treatment response in depression	3
Epigenetic signatures in gastric cancer: current knowledge and future perspectives	3
A profile of the GenePOC Carba C assay for the detection and differentiation of gene sequences associated with carbapenem-non-susceptibility	3
The value of companion diagnostics in oncology drug development	3
The clinical importance of high-sensitivity cardiac troponin measurements for risk prediction in non-cardiac surgery	3
Molecular determination of insect venom allergies	3
The MALAT1-breast cancer interplay: insights and implications	3
The impact of the COVID-19 pandemic on addressing common barriers to pharmacy-based point-of-care testing	3
Diagnostic significance of heart-type fatty acid-binding protein as a potential biomarker to predict the mortality rate of patients with sepsis: a systematic review and meta-analysis	3
Mutations of key driver genes in gastric cancer metastasis risk: a systematic review and meta-analysis	3
An update on current and novel molecular diagnostics for the diagnosis of invasive fungal infections	3
Noninvasive imaging assessment of portal hypertension: where are we now and where does the future lie?	3
Diagnostic profile of the AmplideX Fragile X Dx and Carrier Screen Kit for diagnosis and screening of fragile X syndrome and other FMR1-related disorders	3
Relationship between diagnostic accuracy of microRNAs for NSCLC and number of combined microRNAs: an overview with meta-analysis	3
Known biomarkers for monitoring pregnancy complications	3
A stroll through the present and future of testicular germ cell tumour biomarkers	3
The biomolecular corona of extracellular nanoparticles holds new promises for advancing clinical molecular diagnostics	3
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers	3
SSR4 as a prognostic biomarker and related with immune infiltration cells in colon adenocarcinoma	3
Villin expression in human tumors: a tissue microarray study on 14,398 tumors	3
Clinical utility of the 'Determine HBsAg' Point-of-Care Test for Diagnosis of Hepatitis B Surface Antigen in Africa	3