Expert Review of Molecular Diagnostics

Article	Citations
Evaluating tumor cell- and T cell-derived extracellular vesicles as potential biomarkers of cancer and immune cell competence	93
Harnessing the potential of genomic characterization of mutational profiles to improve early diagnosis of lung cancer	76
Clinicopathological, etiological and molecular characteristics of intrahepatic cholangiocarcinoma subtypes classified by mucin production and immunohistochemical features	69
Molecular charcterization of lung adenocarcinoma combining whole exome sequencing, copy number analysis and gene expression profiling	52
Retrospective analysis of the risk factors associated with failure in obtaining effective noninvasive prenatal test results and pregnancy outcomes: a case-control study	48
Cost analyses for malaria molecular diagnosis for research planners in India and beyond	37
What makes a « good » companion diagnostic in thoracic oncology?	35
Mild behavioral impairment and neurodegeneration: time for a biomarker-based assessment	34
Molecular point-of-care testing in the community pharmacy setting: current status and future prospects	32
Polygenic and Network-based studies in risk identification and demystification of cancer	31
Alzheimer’s disease: a scoping review of biomarker research and development for effective disease diagnosis	30
Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer	30
Nuclease activity: an exploitable biomarker in bacterial infections	29
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer	29
Evolution and future of cervical cancer screening: from cytology to primary HPV testing and the impact of vaccination	29
Recent updates in the development of molecular assays for the rapid identification and susceptibility testing of MRSA	28
Functional proteomic analysis, a missing piece for understanding clonal evolution and cooperation in the tissue microecology	27
Unlocking the power of biomarkers: transforming the diagnosis of acute respiratory distress syndrome	27
A novel anoikis-related signature predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma	26
Diagnostic approach to leptomeningeal involvement in diffuse large B-cell lymphoma	24
The current and future applications of in situ hybridization technologies in anatomical pathology	23
RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?	23
The MALAT1-breast cancer interplay: insights and implications	23
Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma	22
Can multiplex molecular panels of microbial pathogens transform respiratory care in critically ill patients?	22

Clinical application of noninvasive prenatal testing in twin pregnancies: a single-center experience	21
Genetic risk and gastric cancer: polygenic risk scores in population-based case-control study	21
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease	21
Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: racial, ethnic, and geographical considerations	21
Neuroimaging with PET/CT in chronic traumatic encephalopathy: what nuclear medicine can do to move the field forward	20
How mitochondrial DNA complicates pre-implantation genetic screening and management	19
Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis	18
Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers	18
Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma	18
Cell avidity in CAR-T cell therapy	17
Early Identification of Fungal and Mycobacterium Infections in Pulmonary Granulomas Using Metagenomic Next-Generation Sequencing on Formalin fixation and paraffin embedding tissue	17
Mutation profiling of chronic myeloproliferative neoplasms: improving clinical-molecular prognostic models	17
The clinical importance of high-sensitivity cardiac troponin measurements for risk prediction in non-cardiac surgery	17
Optimization of time interval for the measurement of plasma lipids for cardiovascular disease risk assessment	16
Discovery of potential biomarkers for osteoporosis diagnosis by individual omics and multi-omics technologies	16
Genomic determinants of biological aggressiveness and poor prognosis of pancreatic cancers: KRAS and beyond	16
Point-of-care isothermal nucleic acid amplification tests: progress and bottlenecks for extraction-free sample collection and preparation	16
The promise of liquid biopsies in prostate cancer: a potential point-of-care modality for precision oncology	16
Molecular predictors of metastasis in patients with prostate cancer	16
Molecular diagnostic criteria of myeloproliferative neoplasms	16
Efficient screening strategies for severe combined immunodeficiencies in newborns	15
The challenges and potential in developing microRNA associated with regeneration as biomarkers to improve prognostication for liver failure syndromes and hepatocellular carcinoma	15
Patient outcomes improve when a molecular signature test guides treatment decision-making in rheumatoid arthritis	15
The integration of biomarkers and patient-reported outcomes improves prediction of interstitial cystitis syndrome	15
Regulation of biomarker analysis: what can be translated in the clinic?	14
Analytical validation of urine ALCAM ELISA as a test for lupus nephritis	14
LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis	14
Comprehensive genomic profiling: a public health system perspective	14
Early diagnostics of fibromyalgia: an overview of the challenges and opportunities	14
Molecular deciphering of melanoma: advances and challenges of neoadjuvant and perioperative treatment	13
Cystic echinococcosis microRNAs as potential noninvasive biomarkers: current insights and upcoming perspective	13
Extracellular vesicles as source of biomarkers in hematological malignancies: looking towards clinical applications	13
Cytokines as biomarkers of Huntington’s disease progression	13
Reviewing the occurrence of large genomic rearrangements in patients with inherited cancer predisposing syndromes: importance of a comprehensive molecular diagnosis	13
Biomarkers of sleep-wake disturbance as predictors of cognitive decline and accelerated disease progression	12
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease	12
Diagnostic approaches for dengue infection	12
Urinary biomarkers for immunotherapy response in urothelial carcinoma: current status and future outlook	12
Association betweenCDH1methylation and esophageal cancer risk: a meta-analysis and bioinformatics study	12
Faster infection diagnostics for intensive care unit (ICU) patients	12
Association between polymorphisms in TLR3 , TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil	12
An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure	12
Intraoperative detection of axillary metastasis of breast cancer using nucleic acid amplification methods: review of advantages and limitations	12
Prognostic biomarkers in melanoma: a 2023 update from clinical trials in different therapeutic scenarios	11
Decoding pancreatic cancer: key risk factors across genetics and lifestyle	11
Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa	11
Unraveling the future: hot topics shaping molecular diagnostics today	11
Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations	11
Diagnosing, treating and monitoring the inflammatory endotype in osteoarthritis clinical trials	11
The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery	11

Quantitative versus qualitative estrogen and luteinizing hormone testing for personal fertility monitoring	11
The association between blood sodium levels and survival in patients treated with immune checkpoint inhibitors	10
Genetic-based diagnostics of Parkinson’s disease and other Parkinsonian syndromes	10
From detection to action: new diagnostic insights into antifungal resistance	10
MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review	10
Association between NUDT17 polymorphisms and breast cancer risk	10
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers	10
COVID-19 diagnosis: lessons to learn and hints for preparedness	10
Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology	10
Potential role of circulating miR-21 in the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis	10
hTERT rs2735940 polymorphism influences lung cancer risk and overall survival in lung cancer patients undergoing platinum-based doublet chemotherapy	10
Noninvasive prenatal screening in southeast China: clinical application and accuracy evaluation	9
JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence	9
Highlighting and addressing barriers to widespread adaptation of HIV self-testing in the United States	9
Molecular determination of insect venom allergies	9
Advances in pediatric sepsis biomarkers - what have we learnt so far?	9
The role of fecal biomarkers in individuals with inflammatory bowel disease	9
How our molecular understanding of the pathogenesis of Mycobacterium ulcerans infection can improve diagnosis of Buruli ulcer	9
Recent developments in wearable & non-wearable point-of-care biosensors for cortisol detection	8
Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers	8
Determining the accuracy of next generation sequencing based copy number variation analysis in Hereditary Breast and Ovarian Cancer	8
Towards improved point-of-care (POC) testing for patients with suspected sepsis: POC tests for host biomarkers and possible microbial pathogens	8
Future potential of metagenomics in microbiology laboratories	8
Variants of KLF5 and KLF12 were related to endometrial cancer risk in the Chinese population	8
Development and validation of a nomogram for the prediction of metabolic syndrome in polycystic ovary syndrome in a Chinese population	8
Point-of-care urine tenofovir monitoring of adherence to drive interventions for HIV treatment and prevention	8
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers	8
Global polymorphism of Plasmodium falciparum histidine rich proteins 2/3 and impact on malaria rapid diagnostic test detection: a systematic review and meta-analysis	8
Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases	8
Statistical determination of cancer biomarkers: moving forward clinically	8
Cross-sectional risk models using quantitative fecal hemoglobin in colorectal cancer screening: a systematic review	8
Combining oral fluid aMMP-8, calprotectin, and CCAAs in dental panoramic radiography for periodontal disease and systemic disease risk assessment: a point-of-care diagnostic approach	8
Exploring the prognostic and predictive potential of bacterial biomarkers in non-gastrointestinal solid tumors	7
Next-generation sequencing for laboratory diagnosis of infectious diseases	7
How reliable are polygenic risk scores for risk prediction in patients with heart disease?	7
Dual-energy spectral CT in renal cell carcinoma: dawn of a brand-new era?	7
Saliva liquid biopsy for detection of early-stage lesions	7
Loop-mediated isothermal amplification for Candida species surveillance in under-resourced setting: a review of evidence	7
Point-of-care COVID-19 testing in the emergency department: current status and future prospects	7
CD44v6 acts as a directional responding factor in the process of transcoelomic metastasis from gastric carcinoma to Krukenberg tumor	7
Saliva-based Hormone Diagnostics: advances, applications, and future perspectives	7
Blood-based biomarkers of chronic inflammation	7
Diagnostic and predictive value of liquid biopsy-derived exosome miR-21 for breast cancer: a systematic review and meta-analysis	7
A profile of the Visitect® CD4 and Visitect® CD4 advanced disease for management of people living with HIV	7
Validating blood tests as a possible routine diagnostic assay of Alzheimer’s disease	7
What are the diagnostic capabilities of glycans for breast cancer?	7
The status of standardization in methodologies for tear fluid biomarkers	7
Identification of novel biomarkers in renal cell carcinoma	6
A charming molecular profile in the wrong tissue: the pathologist in the era of molecular diagnostics in the gastrointestinal tract	6
TRIB3 overexpression predicts malignant progression and poor prognosis in human solid tumors: bioinformatics validation and clinical significance	6
An update on current and novel molecular diagnostics for the diagnosis of invasive fungal infections	6
Smartphone and wearable diagnostics	6
PCR diagnostic platforms for non- Aspergillus mold infections: ready for routine implementation in the clinic?	6
Correlation between lipoprotein-associated phospholipase A2 and poststroke mild cognitive impairment	6
Evaluation of the performance of the BD MAX MDR-TB test in the diagnosis of Mycobacterium tuberculosis complex in extrapulmonary and pulmonary samples	6
SSR4 as a prognostic biomarker and related with immune infiltration cells in colon adenocarcinoma	5
Brain tumors and circulating micrornas: a systematic review and diagnostic meta-analysis	5
Peripheral blood biomarkers in monitoring treatment response in breast cancer patients	5
Detecting glycoproteins predictors of traumatic brain injury	5
Circulating tumor DNA and urinary tumor DNA: useful biomarkers for bladder cancer detection	5
The tumor immune microenvironment in pancreatic cancer and its potential in the identification of immunotherapy biomarkers	5
Diagnostic accuracy of circulating-free DNA for the determination of hepatocellular carcinoma: a systematic review and meta-analysis	5
The use of metagenomics to enhance diagnosis of encephalitis	5
MicroRnas in preeclampsia	5
Role of N6-methyladenosine modification in pathogenesis of ischemic stroke	5
Evaluation of ctDNA-based ESR1 testing in breast cancer: results from the first external quality assessment scheme in China	5
The biomolecular corona of extracellular nanoparticles holds new promises for advancing clinical molecular diagnostics	5
Strengths and limitations of molecular diagnostics for Pneumocystis jirovecii pneumonia	5
Association between the APOC3 (rs2854116), ESR2 (rs3020450), HFE (rs1799945), and MMP1 (rs1799750) gene polymorphisms and lipodystrophy in people living with HIV receiving antiretroviral therapy	5
Low-cost molecular methodology for blood group antigens identification and genotyping contribution to transfusion efficacy in multiple transfused patients	5
Retrospective analysis of persistent HyperCKemia with or without muscle weakness in a case series from Greece highlights vast DMD variant heterogeneity	5
Creating standards for liquid biopsies: the BLOODPAC experience	5
Development and validation of a ligand–receptor pairs signature to predict outcome and provide a therapeutic strategy in gastric cancer	5
Diagnostic accuracy of CRISPR technology for detecting SARS-CoV-2: a systematic review and meta-analysis	5
Diagnostic accuracy of serum derived exosomes for hepatocellular carcinoma: a systematic review and meta-analysis	5
Challenges in diagnosing hydatidiform moles: a review of promising molecular biomarkers	5
We have reached single-visit testing, diagnosis, and treatment for hepatitis C infection, now what?	5
α-synuclein as an emerging pathophysiological biomarker of Alzheimer’s disease	5
Promising biomarkers of Kawasaki disease: markers that aid in diagnosis	5
RT-LAMP in SARS-CoV-2 detection: point to improve primer designing and decrease molecular diagnosis pitfalls	5

Diagnostic significance of heart-type fatty acid-binding protein as a potential biomarker to predict the mortality rate of patients with sepsis: a systematic review and meta-analysis	5
Whole genome amplicon sequencing and phylogenetic analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from lineage B.1.36.27 isolated in Hong Kong	5
Detection of lung cancer and stages via breath analysis using a self-made electronic nose device	5
Practical considerations for pathological diagnosis and molecular profiling of cholangiocarcinoma: an expert review for best practices	4
[ 68 Ga]PSMA-11 for positron emission tomography (PET) imaging of prostate-specific membrane antigen (PSMA)-positive lesions in men with prostate cancer	4
Primary open-angle glaucoma: a perspective from plasma metabolomics	4
Clinical utilization of airway inflammatory biomarkers in the prediction and monitoring of clinical outcomes in patients with chronic obstructive pulmonary disease	4
Genetic variant in LncRNA-NKILA associated with gastric cancer susceptibility and the binding with miR-6731-5p	4
Promotor methylation in ocular surface squamous neoplasia development: epigenetics implications in molecular diagnosis	4
Enhanced mitochondrial genome analysis: bioinformatic and long-read sequencing advances and their diagnostic implications	4
Are we closer to robust predictors of recurrent pregnancy loss by means of integrating different types of omics data?	4
A sandwich chemiluminescent magnetic microparticle immunoassay for cryptococcal antigen detection	4
Borderline SARS-CoV-2 patients: the trace behind	4
Next generation immuno-oncology biomarkers in gastrointestinal cancer: what does the future hold?	4
Potential of CRISPR/Cas system in the diagnosis of COVID-19 infection	4
Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry	4
The emerging role of liquid biopsy in oral squamous cell carcinoma detection: advantages and challenges	4
Combined exome analysis and exome depth assessment achieve a high diagnostic yield in an epilepsy case series, revealing significant genomic heterogeneity and novel mechanisms	4
Comet-FISH analysis of urothelial cells. A screening opportunity for bladder cancer?	4
Paving the way for quality assured, decentralised point-of-care testing for infectious disease in primary care - Real world lessons from remote Australia	4
Blood soluble Fas concentrations and ischemic stroke patient mortality	4
Screening for oropharyngeal cancer: the time is now	4
Circulating tumor DNA as a powerful tool in diagnostics and treatment outcome prediction – focus on large B–cell lymphomas and follicular lymphomas	4
How can we improve the successful identification of patients suitable for CAR-T cell therapy?	4
Gestational trophoblastic disease: STR genotyping for precision diagnosis	4
The potency of cell-based assays to predict response to TNF inhibitor therapy	4
Research advancement in fluid biomarkers for Parkinson’s disease	4
Lost in translation: the pitfalls of Ensembl gene annotations between human genome assemblies and their impact on diagnostics	4
Advances in RT-LAMP for COVID-19 testing and diagnosis	4
Diagnostic accuracy of clinically applied nanoparticle-based biosensors at detecting SARS-CoV-2 RNA and surface proteins in pharyngeal swabs compared to RT-PCR as a reference test	4
Sample-to-result molecular diagnostic platforms and their suitability for infectious disease testing in low- and middle-income countries	3
Molecular biomarkers of blunt cardiac injury: recent advances and future perspectives	3
The diagnosis of Huntington’s disease by different molecular tools: a systematic review	3
Implementing Individualized quality control plans and managing risk at the point-of-care for molecular diagnostics	3
Villin expression in human tumors: a tissue microarray study on 14,398 tumors	3
Advances in tests for colorectal cancer screening and diagnosis	3
Brain exosomes as minuscule information hub for Autism Spectrum Disorder	3
Evaluation of transcriptomic molecular classification, biological behavior, and clinicopathological features in hepatocellular carcinoma	3
Gastrin-releasing peptide receptor agonists and antagonists for molecular imaging of breast and prostate cancer: from pre-clinical studies to translational perspectives	3
Current status of diagnostic assays for emerging zoonotic viruses: Nipah and Hendra	3
Perspective: cell death mechanisms and early diagnosis as precondition for disease modification in Parkinson’s disease: are we on the right track?	3
Technical aspects of loop‐mediated isothermal amplification (LAMP) assay in cancer	3
Analytical and clinical validation of an RNA sequencing-based assay for quantitative, accurate evaluation of a molecular signature response classifier in rheumatoid arthritis	3
Clinical utility of reproductive carrier screening for preconception and pregnant couples for multiple genetic conditions: a systematic review and meta-analysis	3
A review of the value of point-of-care testing for community-acquired pneumonia	3
Diagnosis and management of invasive fungal diseases by next-generation sequencing: are we there yet?	3
Circulating microRNA biomarkers in melanoma and non-melanoma skin cancer	3
Genetic profiling of upper tract urothelial carcinoma: A necessity for precision medicine	3
Research tests for the diagnosis of tuberculosis infection	3
Emerging prognostic biomarkers in advanced cutaneous melanoma: a literature update	3
Advances in pancreatic cancer diagnosis: from DNA methylation to AI-assisted imaging	3
Diagnosis of COVID-19: hemagglutinin-esterase gene is used for molecular assays?	3
Updates in diagnosing polycystic ovary syndrome-related infertility	3
Point-of-care testing for viral-associated pulmonary aspergillosis	3
The game changer: UCH-L1 and GFAP-based blood test as the first marketed in vitro diagnostic test for mild traumatic brain injury	3
Serum Fas levels during first week of sepsis are associated with severity and mortality	3
Applications of ctDNA testing to monitor and detect residual disease in breast cancer	3
Clinical value of identifying genes that inhibit hepatocellular carcinomas	3
Smaller, cheaper, faster: where next for liquid biopsies?	3
Overview of point-of-care diagnostic options for detection of chlamydia trachomatis : current technology and implementation considerations	3
Association between the first and second trimester cell free DNA fetal fraction and spontaneous preterm birth	3
Diagnostic utility of rapid sequencing in critically ill infants: a systematic review and meta-analysis	3