Expert Review of Molecular Diagnostics

Article	Citations
Evaluating tumor cell- and T cell-derived extracellular vesicles as potential biomarkers of cancer and immune cell competence	87
Cost analyses for malaria molecular diagnosis for research planners in India and beyond	69
Mild behavioral impairment and neurodegeneration: time for a biomarker-based assessment	65
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer	50
Recent updates in the development of molecular assays for the rapid identification and susceptibility testing of MRSA	42
What makes a « good » companion diagnostic in thoracic oncology?	35
Clinicopathological, etiological and molecular characteristics of intrahepatic cholangiocarcinoma subtypes classified by mucin production and immunohistochemical features	33
Analytical validation of a novel multi-target blood-based test to detect hepatocellular carcinoma	31
Molecular point-of-care testing in the community pharmacy setting: current status and future prospects	31
Polygenic and Network-based studies in risk identification and demystification of cancer	30
Retrospective analysis of the risk factors associated with failure in obtaining effective noninvasive prenatal test results and pregnancy outcomes: a case-control study	29
Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer	29
Nuclease activity: an exploitable biomarker in bacterial infections	27
Alzheimer’s disease: a scoping review of biomarker research and development for effective disease diagnosis	27
Harnessing the potential of genomic characterization of mutational profiles to improve early diagnosis of lung cancer	27
Molecular charcterization of lung adenocarcinoma combining whole exome sequencing, copy number analysis and gene expression profiling	25
Evolution and future of cervical cancer screening: from cytology to primary HPV testing and the impact of vaccination	25
Unlocking the power of biomarkers: transforming the diagnosis of acute respiratory distress syndrome	24
Diagnostic approach to leptomeningeal involvement in diffuse large B-cell lymphoma	23
RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?	22
A novel anoikis-related signature predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma	22
The MALAT1-breast cancer interplay: insights and implications	21
The current and future applications of in situ hybridization technologies in anatomical pathology	21
Genetic risk and gastric cancer: polygenic risk scores in population-based case-control study	21
Functional proteomic analysis, a missing piece for understanding clonal evolution and cooperation in the tissue microecology	21

Clinical application of noninvasive prenatal testing in twin pregnancies: a single-center experience	20
Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma	20
Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma	20
Neuroimaging with PET/CT in chronic traumatic encephalopathy: what nuclear medicine can do to move the field forward	19
Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers	19
Can multiplex molecular panels of microbial pathogens transform respiratory care in critically ill patients?	18
Early Identification of Fungal and Mycobacterium Infections in Pulmonary Granulomas Using Metagenomic Next-Generation Sequencing on Formalin fixation and paraffin embedding tissue	17
How mitochondrial DNA complicates pre-implantation genetic screening and management	17
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease	17
Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: racial, ethnic, and geographical considerations	17
Molecular predictors of metastasis in patients with prostate cancer	16
Optimization of time interval for the measurement of plasma lipids for cardiovascular disease risk assessment	16
The clinical importance of high-sensitivity cardiac troponin measurements for risk prediction in non-cardiac surgery	16
Efficient screening strategies for severe combined immunodeficiencies in newborns	16
Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis	16
LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis	15
Molecular diagnostic criteria of myeloproliferative neoplasms	15
Comprehensive genomic profiling: a public health system perspective	15
Regulation of biomarker analysis: what can be translated in the clinic?	15
Discovery of potential biomarkers for osteoporosis diagnosis by individual omics and multi-omics technologies	14
The integration of biomarkers and patient-reported outcomes improves prediction of interstitial cystitis syndrome	14
The challenges and potential in developing microRNA associated with regeneration as biomarkers to improve prognostication for liver failure syndromes and hepatocellular carcinoma	14
Patient outcomes improve when a molecular signature test guides treatment decision-making in rheumatoid arthritis	14
Genomic determinants of biological aggressiveness and poor prognosis of pancreatic cancers: KRAS and beyond	14
Molecular deciphering of melanoma: advances and challenges of neoadjuvant and perioperative treatment	13
Point-of-care isothermal nucleic acid amplification tests: progress and bottlenecks for extraction-free sample collection and preparation	13
Cystic echinococcosis microRNAs as potential noninvasive biomarkers: current insights and upcoming perspective	13
Extracellular vesicles as source of biomarkers in hematological malignancies: looking towards clinical applications	13
Analytical validation of urine ALCAM ELISA as a test for lupus nephritis	13
Biomarkers of sleep-wake disturbance as predictors of cognitive decline and accelerated disease progression	12
Reviewing the occurrence of large genomic rearrangements in patients with inherited cancer predisposing syndromes: importance of a comprehensive molecular diagnosis	12
Association betweenCDH1methylation and esophageal cancer risk: a meta-analysis and bioinformatics study	12
Decoding pancreatic cancer: key risk factors across genetics and lifestyle	12
Early diagnostics of fibromyalgia: an overview of the challenges and opportunities	12
Cytokines as biomarkers of Huntington’s disease progression	12
Intraoperative detection of axillary metastasis of breast cancer using nucleic acid amplification methods: review of advantages and limitations	12
An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure	12
Association between polymorphisms in TLR3 , TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil	12
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease	12
Quantitative versus qualitative estrogen and luteinizing hormone testing for personal fertility monitoring	12
Prognostic biomarkers in melanoma: a 2023 update from clinical trials in different therapeutic scenarios	11
Faster infection diagnostics for intensive care unit (ICU) patients	11
Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations	11
Diagnostic approaches for dengue infection	11
Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology	11
Diagnosing, treating and monitoring the inflammatory endotype in osteoarthritis clinical trials	11
Unraveling the future: hot topics shaping molecular diagnostics today	11
The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery	11
Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa	11
hTERT rs2735940 polymorphism influences lung cancer risk and overall survival in lung cancer patients undergoing platinum-based doublet chemotherapy	10

From detection to action: new diagnostic insights into antifungal resistance	10
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers	10
The association between blood sodium levels and survival in patients treated with immune checkpoint inhibitors	10
MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review	10
Genetic-based diagnostics of Parkinson’s disease and other Parkinsonian syndromes	10
Potential role of circulating miR-21 in the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis	10
Determining the accuracy of next generation sequencing based copy number variation analysis in Hereditary Breast and Ovarian Cancer	9
Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers	9
Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases	9
Noninvasive prenatal screening in southeast China: clinical application and accuracy evaluation	9
Association between NUDT17 polymorphisms and breast cancer risk	9
Molecular determination of insect venom allergies	9
JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence	9
The role of fecal biomarkers in individuals with inflammatory bowel disease	9
Advances in pediatric sepsis biomarkers - what have we learnt so far?	9
How our molecular understanding of the pathogenesis of Mycobacterium ulcerans infection can improve diagnosis of Buruli ulcer	9
Highlighting and addressing barriers to widespread adaptation of HIV self-testing in the United States	9
Statistical determination of cancer biomarkers: moving forward clinically	9
Recent developments in wearable & non-wearable point-of-care biosensors for cortisol detection	9
COVID-19 diagnosis: lessons to learn and hints for preparedness	9
Point-of-care urine tenofovir monitoring of adherence to drive interventions for HIV treatment and prevention	8
Cross-sectional risk models using quantitative fecal hemoglobin in colorectal cancer screening: a systematic review	8
Global polymorphism of Plasmodium falciparum histidine rich proteins 2/3 and impact on malaria rapid diagnostic test detection: a systematic review and meta-analysis	8
CD44v6 acts as a directional responding factor in the process of transcoelomic metastasis from gastric carcinoma to Krukenberg tumor	8
Saliva-based Hormone Diagnostics: advances, applications, and future perspectives	8
Future potential of metagenomics in microbiology laboratories	8
Variants of KLF5 and KLF12 were related to endometrial cancer risk in the Chinese population	8
How reliable are polygenic risk scores for risk prediction in patients with heart disease?	8
Towards improved point-of-care (POC) testing for patients with suspected sepsis: POC tests for host biomarkers and possible microbial pathogens	8
Exploring the prognostic and predictive potential of bacterial biomarkers in non-gastrointestinal solid tumors	7
Genetic variations as molecular diagnostic factors for idiopathic male infertility: current knowledge and future perspectives	7
Point-of-care COVID-19 testing in the emergency department: current status and future prospects	7
Dual-energy spectral CT in renal cell carcinoma: dawn of a brand-new era?	7
Loop-mediated isothermal amplification for Candida species surveillance in under-resourced setting: a review of evidence	7
Blood-based biomarkers of chronic inflammation	7
Smartphone and wearable diagnostics	7
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers	7
Validating blood tests as a possible routine diagnostic assay of Alzheimer’s disease	7
Diagnostic and predictive value of liquid biopsy-derived exosome miR-21 for breast cancer: a systematic review and meta-analysis	7
Next-generation sequencing for laboratory diagnosis of infectious diseases	7
Correlation between lipoprotein-associated phospholipase A2 and poststroke mild cognitive impairment	7
What are the diagnostic capabilities of glycans for breast cancer?	7
The status of standardization in methodologies for tear fluid biomarkers	7
Creating standards for liquid biopsies: the BLOODPAC experience	6
An update on current and novel molecular diagnostics for the diagnosis of invasive fungal infections	6
A charming molecular profile in the wrong tissue: the pathologist in the era of molecular diagnostics in the gastrointestinal tract	6
Development and validation of a ligand–receptor pairs signature to predict outcome and provide a therapeutic strategy in gastric cancer	6
PCR diagnostic platforms for non- Aspergillus mold infections: ready for routine implementation in the clinic?	6
Evaluation of the performance of the BD MAX MDR-TB test in the diagnosis of Mycobacterium tuberculosis complex in extrapulmonary and pulmonary samples	6
TRIB3 overexpression predicts malignant progression and poor prognosis in human solid tumors: bioinformatics validation and clinical significance	6
MicroRnas in preeclampsia	6
Identification of novel biomarkers in renal cell carcinoma	6
A profile of the Visitect® CD4 and Visitect® CD4 advanced disease for management of people living with HIV	6
Detection of lung cancer and stages via breath analysis using a self-made electronic nose device	6
Brain tumors and circulating micrornas: a systematic review and diagnostic meta-analysis	5
Retrospective analysis of persistent HyperCKemia with or without muscle weakness in a case series from Greece highlights vast DMD variant heterogeneity	5
Diagnostic accuracy of CRISPR technology for detecting SARS-CoV-2: a systematic review and meta-analysis	5
The tumor immune microenvironment in pancreatic cancer and its potential in the identification of immunotherapy biomarkers	5
Peripheral blood biomarkers in monitoring treatment response in breast cancer patients	5
The use of metagenomics to enhance diagnosis of encephalitis	5
Low-cost molecular methodology for blood group antigens identification and genotyping contribution to transfusion efficacy in multiple transfused patients	5
SSR4 as a prognostic biomarker and related with immune infiltration cells in colon adenocarcinoma	5
Viral metagenomic sequencing in the diagnosis of meningoencephalitis: a review of technical advances and diagnostic yield	5
Diagnostic accuracy of serum derived exosomes for hepatocellular carcinoma: a systematic review and meta-analysis	5
Enhanced mitochondrial genome analysis: bioinformatic and long-read sequencing advances and their diagnostic implications	5
Whole genome amplicon sequencing and phylogenetic analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from lineage B.1.36.27 isolated in Hong Kong	5
Diagnostic significance of heart-type fatty acid-binding protein as a potential biomarker to predict the mortality rate of patients with sepsis: a systematic review and meta-analysis	5
RT-LAMP in SARS-CoV-2 detection: point to improve primer designing and decrease molecular diagnosis pitfalls	5
Role of N6-methyladenosine modification in pathogenesis of ischemic stroke	5
Promising biomarkers of Kawasaki disease: markers that aid in diagnosis	5
Diagnostic accuracy of circulating-free DNA for the determination of hepatocellular carcinoma: a systematic review and meta-analysis	5
A sandwich chemiluminescent magnetic microparticle immunoassay for cryptococcal antigen detection	4
Strengths and limitations of molecular diagnostics for Pneumocystis jirovecii pneumonia	4
α-synuclein as an emerging pathophysiological biomarker of Alzheimer’s disease	4
Borderline SARS-CoV-2 patients: the trace behind	4
Gestational trophoblastic disease: STR genotyping for precision diagnosis	4
Next generation immuno-oncology biomarkers in gastrointestinal cancer: what does the future hold?	4
Promotor methylation in ocular surface squamous neoplasia development: epigenetics implications in molecular diagnosis	4
Paving the way for quality assured, decentralised point-of-care testing for infectious disease in primary care - Real world lessons from remote Australia	4
Advances in RT-LAMP for COVID-19 testing and diagnosis	4

Potential of CRISPR/Cas system in the diagnosis of COVID-19 infection	4
The biomolecular corona of extracellular nanoparticles holds new promises for advancing clinical molecular diagnostics	4
Evaluation of ctDNA-based ESR1 testing in breast cancer: results from the first external quality assessment scheme in China	4
We have reached single-visit testing, diagnosis, and treatment for hepatitis C infection, now what?	4
Screening for oropharyngeal cancer: the time is now	4
Challenges in diagnosing hydatidiform moles: a review of promising molecular biomarkers	4
Circulating tumor DNA as a powerful tool in diagnostics and treatment outcome prediction – focus on large B–cell lymphomas and follicular lymphomas	4
Clinical utilization of airway inflammatory biomarkers in the prediction and monitoring of clinical outcomes in patients with chronic obstructive pulmonary disease	4
Research advancement in fluid biomarkers for Parkinson’s disease	4
Blood soluble Fas concentrations and ischemic stroke patient mortality	4
[ 68 Ga]PSMA-11 for positron emission tomography (PET) imaging of prostate-specific membrane antigen (PSMA)-positive lesions in men with prostate cancer	4
Liquid biopsy from research to clinical practice: focus on non-small cell lung cancer	4
Diagnostic accuracy of clinically applied nanoparticle-based biosensors at detecting SARS-CoV-2 RNA and surface proteins in pharyngeal swabs compared to RT-PCR as a reference test	4
Practical considerations for pathological diagnosis and molecular profiling of cholangiocarcinoma: an expert review for best practices	4
Detecting glycoproteins predictors of traumatic brain injury	4
Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry	4
Comet-FISH analysis of urothelial cells. A screening opportunity for bladder cancer?	4
Predictive biomarkers for systemic therapy of hepatocellular carcinoma	4
The potency of cell-based assays to predict response to TNF inhibitor therapy	4
Combined exome analysis and exome depth assessment achieve a high diagnostic yield in an epilepsy case series, revealing significant genomic heterogeneity and novel mechanisms	4
Brain exosomes as minuscule information hub for Autism Spectrum Disorder	3
Primary open-angle glaucoma: a perspective from plasma metabolomics	3
Are we closer to robust predictors of recurrent pregnancy loss by means of integrating different types of omics data?	3
Clinical value of identifying genes that inhibit hepatocellular carcinomas	3
Villin expression in human tumors: a tissue microarray study on 14,398 tumors	3
Point-of-care testing for viral-associated pulmonary aspergillosis	3
Emerging prognostic biomarkers in advanced cutaneous melanoma: a literature update	3
Association between the first and second trimester cell free DNA fetal fraction and spontaneous preterm birth	3
Serum Fas levels during first week of sepsis are associated with severity and mortality	3
Advances in tests for colorectal cancer screening and diagnosis	3
Evaluation of transcriptomic molecular classification, biological behavior, and clinicopathological features in hepatocellular carcinoma	3
Diagnosis and management of invasive fungal diseases by next-generation sequencing: are we there yet?	3
Smaller, cheaper, faster: where next for liquid biopsies?	3
Lost in translation: the pitfalls of Ensembl gene annotations between human genome assemblies and their impact on diagnostics	3
Genetic profiling of upper tract urothelial carcinoma: A necessity for precision medicine	3
Implementing Individualized quality control plans and managing risk at the point-of-care for molecular diagnostics	3
Clinical utility of reproductive carrier screening for preconception and pregnant couples for multiple genetic conditions: a systematic review and meta-analysis	3
The diagnosis of Huntington’s disease by different molecular tools: a systematic review	3
Research tests for the diagnosis of tuberculosis infection	3
Gastrin-releasing peptide receptor agonists and antagonists for molecular imaging of breast and prostate cancer: from pre-clinical studies to translational perspectives	3
Applications of ctDNA testing to monitor and detect residual disease in breast cancer	3
The game changer: UCH-L1 and GFAP-based blood test as the first marketed in vitro diagnostic test for mild traumatic brain injury	3
The emerging role of liquid biopsy in oral squamous cell carcinoma detection: advantages and challenges	3
Genetic variant in LncRNA-NKILA associated with gastric cancer susceptibility and the binding with miR-6731-5p	3
How can we improve the successful identification of patients suitable for CAR-T cell therapy?	3
Current status of diagnostic assays for emerging zoonotic viruses: Nipah and Hendra	3
Analytical and clinical validation of an RNA sequencing-based assay for quantitative, accurate evaluation of a molecular signature response classifier in rheumatoid arthritis	3
Molecular biomarkers of blunt cardiac injury: recent advances and future perspectives	3
Overview of point-of-care diagnostic options for detection of chlamydia trachomatis : current technology and implementation considerations	3
A review of the value of point-of-care testing for community-acquired pneumonia	3
Circulating microRNA biomarkers in melanoma and non-melanoma skin cancer	3