Expert Review of Molecular Diagnostics

Article	Citations
Alzheimer’s disease: a scoping review of biomarker research and development for effective disease diagnosis	82
Evaluating tumor cell- and T cell-derived extracellular vesicles as potential biomarkers of cancer and immune cell competence	67
Retrospective analysis of the risk factors associated with failure in obtaining effective noninvasive prenatal test results and pregnancy outcomes: a case-control study	64
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer	55
Mild behavioral impairment and neurodegeneration: time for a biomarker-based assessment	48
Recent updates in the development of molecular assays for the rapid identification and susceptibility testing of MRSA	41
Molecular point-of-care testing in the community pharmacy setting: current status and future prospects	35
Analytical validation of a novel multi-target blood-based test to detect hepatocellular carcinoma	34
Polygenic and Network-based studies in risk identification and demystification of cancer	32
Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer	31
Gene fusions in vascular tumors and their underlying molecular mechanisms	29
Cost analyses for malaria molecular diagnosis for research planners in India and beyond	28
Harnessing the potential of genomic characterization of mutational profiles to improve early diagnosis of lung cancer	28
Molecular charcterization of lung adenocarcinoma combining whole exome sequencing, copy number analysis and gene expression profiling	27
Nuclease activity: an exploitable biomarker in bacterial infections	27
Evolution and future of cervical cancer screening: from cytology to primary HPV testing and the impact of vaccination	25
Clinicopathological, etiological and molecular characteristics of intrahepatic cholangiocarcinoma subtypes classified by mucin production and immunohistochemical features	25
What makes a « good » companion diagnostic in thoracic oncology?	25
Diagnostic approach to leptomeningeal involvement in diffuse large B-cell lymphoma	24
Unlocking the power of biomarkers: transforming the diagnosis of acute respiratory distress syndrome	24
Functional proteomic analysis, a missing piece for understanding clonal evolution and cooperation in the tissue microecology	23
RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?	22
The MALAT1-breast cancer interplay: insights and implications	21
Enzymatic cross-linking of collagens in organ fibrosis – resolution and assessment	21
The current and future applications of in situ hybridization technologies in anatomical pathology	21

A novel anoikis-related signature predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma	21
Genetic risk and gastric cancer: polygenic risk scores in population-based case-control study	21
Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis	19
Clinical application of noninvasive prenatal testing in twin pregnancies: a single-center experience	19
Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma	19
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease	18
Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: racial, ethnic, and geographical considerations	18
Can multiplex molecular panels of microbial pathogens transform respiratory care in critically ill patients?	18
Early Identification of Fungal and Mycobacterium Infections in Pulmonary Granulomas Using Metagenomic Next-Generation Sequencing on Formalin fixation and paraffin embedding tissue	18
Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma	17
Neuroimaging with PET/CT in chronic traumatic encephalopathy: what nuclear medicine can do to move the field forward	17
Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers	17
Optimization of time interval for the measurement of plasma lipids for cardiovascular disease risk assessment	16
Comprehensive genomic profiling: a public health system perspective	16
The clinical importance of high-sensitivity cardiac troponin measurements for risk prediction in non-cardiac surgery	16
Molecular predictors of metastasis in patients with prostate cancer	16
Efficient screening strategies for severe combined immunodeficiencies in newborns	16
LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis	16
Molecular diagnostic criteria of myeloproliferative neoplasms	15
Point-of-care isothermal nucleic acid amplification tests: progress and bottlenecks for extraction-free sample collection and preparation	14
Patient outcomes improve when a molecular signature test guides treatment decision-making in rheumatoid arthritis	14
The challenges and potential in developing microRNA associated with regeneration as biomarkers to improve prognostication for liver failure syndromes and hepatocellular carcinoma	14
Genomic determinants of biological aggressiveness and poor prognosis of pancreatic cancers: KRAS and beyond	14
The integration of biomarkers and patient-reported outcomes improves prediction of interstitial cystitis syndrome	14
Discovery of potential biomarkers for osteoporosis diagnosis by individual omics and multi-omics technologies	14
Analytical validation of urine ALCAM ELISA as a test for lupus nephritis	13
Biomarkers of sleep-wake disturbance as predictors of cognitive decline and accelerated disease progression	13
Reviewing the occurrence of large genomic rearrangements in patients with inherited cancer predisposing syndromes: importance of a comprehensive molecular diagnosis	13
Association between polymorphisms in TLR3 , TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil	13
Faster infection diagnostics for intensive care unit (ICU) patients	12
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease	12
Extracellular vesicles as source of biomarkers in hematological malignancies: looking towards clinical applications	12
An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure	12
Cytokines as biomarkers of Huntington’s disease progression	12
Characteristics of circRNA and its approach as diagnostic tool in melanoma	12
Cystic echinococcosis microRNAs as potential noninvasive biomarkers: current insights and upcoming perspective	12
Early diagnostics of fibromyalgia: an overview of the challenges and opportunities	12
Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers	11
Quantitative versus qualitative estrogen and luteinizing hormone testing for personal fertility monitoring	11
Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa	11
Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations	11
An updated review of the role of lncRNAs and their contribution in various molecular subtypes of breast cancer	11
Prognostic biomarkers in melanoma: a 2023 update from clinical trials in different therapeutic scenarios	11
Decoding pancreatic cancer: key risk factors across genetics and lifestyle	11
Intraoperative detection of axillary metastasis of breast cancer using nucleic acid amplification methods: review of advantages and limitations	11
The association between blood sodium levels and survival in patients treated with immune checkpoint inhibitors	11
The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery	11
Diagnostic approaches for dengue infection	11
Association betweenCDH1methylation and esophageal cancer risk: a meta-analysis and bioinformatics study	11
Unraveling the future: hot topics shaping molecular diagnostics today	11

Potential role of circulating miR-21 in the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis	11
Genetic-based diagnostics of Parkinson’s disease and other Parkinsonian syndromes	10
Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology	10
MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review	10
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers	10
From detection to action: new diagnostic insights into antifungal resistance	10
hTERT rs2735940 polymorphism influences lung cancer risk and overall survival in lung cancer patients undergoing platinum-based doublet chemotherapy	10
COVID-19 diagnosis: lessons to learn and hints for preparedness	10
Statistical determination of cancer biomarkers: moving forward clinically	9
The role of fecal biomarkers in individuals with inflammatory bowel disease	9
Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases	9
JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence	9
How our molecular understanding of the pathogenesis of Mycobacterium ulcerans infection can improve diagnosis of Buruli ulcer	9
Association between NUDT17 polymorphisms and breast cancer risk	9
Recent developments in wearable & non-wearable point-of-care biosensors for cortisol detection	9
Molecular determination of insect venom allergies	9
Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers	9
Noninvasive prenatal screening in southeast China: clinical application and accuracy evaluation	9
Known biomarkers for monitoring pregnancy complications	9
Advances in pediatric sepsis biomarkers - what have we learnt so far?	9
Highlighting and addressing barriers to widespread adaptation of HIV self-testing in the United States	9
Saliva-based Hormone Diagnostics: advances, applications, and future perspectives	8
Determining the accuracy of next generation sequencing based copy number variation analysis in Hereditary Breast and Ovarian Cancer	8
Variants of KLF5 and KLF12 were related to endometrial cancer risk in the Chinese population	8
What are the diagnostic capabilities of glycans for breast cancer?	8
Point-of-care COVID-19 testing in the emergency department: current status and future prospects	8
Point-of-care urine tenofovir monitoring of adherence to drive interventions for HIV treatment and prevention	8
Future potential of metagenomics in microbiology laboratories	8
Global polymorphism of Plasmodium falciparum histidine rich proteins 2/3 and impact on malaria rapid diagnostic test detection: a systematic review and meta-analysis	8
Dual-energy spectral CT in renal cell carcinoma: dawn of a brand-new era?	8
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers	8
Towards improved point-of-care (POC) testing for patients with suspected sepsis: POC tests for host biomarkers and possible microbial pathogens	8
How reliable are polygenic risk scores for risk prediction in patients with heart disease?	8
Cross-sectional risk models using quantitative fecal hemoglobin in colorectal cancer screening: a systematic review	8
CD44v6 acts as a directional responding factor in the process of transcoelomic metastasis from gastric carcinoma to Krukenberg tumor	8
The status of standardization in methodologies for tear fluid biomarkers	7
Exploring the prognostic and predictive potential of bacterial biomarkers in non-gastrointestinal solid tumors	7
TRIB3 overexpression predicts malignant progression and poor prognosis in human solid tumors: bioinformatics validation and clinical significance	7
MicroRnas in preeclampsia	7
A profile of the Visitect® CD4 and Visitect® CD4 advanced disease for management of people living with HIV	7
Next-generation sequencing for laboratory diagnosis of infectious diseases	7
Blood-based biomarkers of chronic inflammation	7
Diagnostic and predictive value of liquid biopsy-derived exosome miR-21 for breast cancer: a systematic review and meta-analysis	7
Smartphone and wearable diagnostics	7
Creating standards for liquid biopsies: the BLOODPAC experience	7
Validating blood tests as a possible routine diagnostic assay of Alzheimer’s disease	7
Loop-mediated isothermal amplification for Candida species surveillance in under-resourced setting: a review of evidence	7
Genetic variations as molecular diagnostic factors for idiopathic male infertility: current knowledge and future perspectives	7
Correlation between lipoprotein-associated phospholipase A2 and poststroke mild cognitive impairment	7
PCR diagnostic platforms for non- Aspergillus mold infections: ready for routine implementation in the clinic?	7
Detection of lung cancer and stages via breath analysis using a self-made electronic nose device	6
Development and validation of a ligand–receptor pairs signature to predict outcome and provide a therapeutic strategy in gastric cancer	6
Brain tumors and circulating micrornas: a systematic review and diagnostic meta-analysis	6
Retrospective analysis of persistent HyperCKemia with or without muscle weakness in a case series from Greece highlights vast DMD variant heterogeneity	6
Whole genome amplicon sequencing and phylogenetic analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from lineage B.1.36.27 isolated in Hong Kong	6
An update on current and novel molecular diagnostics for the diagnosis of invasive fungal infections	6
Identification of novel biomarkers in renal cell carcinoma	6
The use of metagenomics to enhance diagnosis of encephalitis	6
Low-cost molecular methodology for blood group antigens identification and genotyping contribution to transfusion efficacy in multiple transfused patients	6
SSR4 as a prognostic biomarker and related with immune infiltration cells in colon adenocarcinoma	6
A charming molecular profile in the wrong tissue: the pathologist in the era of molecular diagnostics in the gastrointestinal tract	6
Evaluation of the performance of the BD MAX MDR-TB test in the diagnosis of Mycobacterium tuberculosis complex in extrapulmonary and pulmonary samples	6
The tumor immune microenvironment in pancreatic cancer and its potential in the identification of immunotherapy biomarkers	6
Diagnostic significance of heart-type fatty acid-binding protein as a potential biomarker to predict the mortality rate of patients with sepsis: a systematic review and meta-analysis	6
Diagnostic accuracy of circulating-free DNA for the determination of hepatocellular carcinoma: a systematic review and meta-analysis	6
Liquid biopsy from research to clinical practice: focus on non-small cell lung cancer	5
Diagnostic accuracy of CRISPR technology for detecting SARS-CoV-2: a systematic review and meta-analysis	5
Diagnostic accuracy of serum derived exosomes for hepatocellular carcinoma: a systematic review and meta-analysis	5
Strengths and limitations of molecular diagnostics for Pneumocystis jirovecii pneumonia	5
Challenges in diagnosing hydatidiform moles: a review of promising molecular biomarkers	5
Promising biomarkers of Kawasaki disease: markers that aid in diagnosis	5
Role of N6-methyladenosine modification in pathogenesis of ischemic stroke	5
Peripheral blood biomarkers in monitoring treatment response in breast cancer patients	5
Screening for oropharyngeal cancer: the time is now	5
α-synuclein as an emerging pathophysiological biomarker of Alzheimer’s disease	5
RT-LAMP in SARS-CoV-2 detection: point to improve primer designing and decrease molecular diagnosis pitfalls	5
Viral metagenomic sequencing in the diagnosis of meningoencephalitis: a review of technical advances and diagnostic yield	5
Enhanced mitochondrial genome analysis: bioinformatic and long-read sequencing advances and their diagnostic implications	5
Borderline SARS-CoV-2 patients: the trace behind	5
Diagnostic accuracy of clinically applied nanoparticle-based biosensors at detecting SARS-CoV-2 RNA and surface proteins in pharyngeal swabs compared to RT-PCR as a reference test	4

Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry	4
Circulating tumor DNA as a powerful tool in diagnostics and treatment outcome prediction – focus on large B–cell lymphomas and follicular lymphomas	4
Potential of CRISPR/Cas system in the diagnosis of COVID-19 infection	4
The emerging role of liquid biopsy in oral squamous cell carcinoma detection: advantages and challenges	4
Lost in translation: the pitfalls of Ensembl gene annotations between human genome assemblies and their impact on diagnostics	4
Paving the way for quality assured, decentralised point-of-care testing for infectious disease in primary care - Real world lessons from remote Australia	4
Promotor methylation in ocular surface squamous neoplasia development: epigenetics implications in molecular diagnosis	4
Practical considerations for pathological diagnosis and molecular profiling of cholangiocarcinoma: an expert review for best practices	4
A sandwich chemiluminescent magnetic microparticle immunoassay for cryptococcal antigen detection	4
Highly sensitive droplet digital PCR-based diagnostics for the surveillance of malaria vector populations in low transmission and incipient resistance settings	4
The biomolecular corona of extracellular nanoparticles holds new promises for advancing clinical molecular diagnostics	4
Advances in RT-LAMP for COVID-19 testing and diagnosis	4
Combined exome analysis and exome depth assessment achieve a high diagnostic yield in an epilepsy case series, revealing significant genomic heterogeneity and novel mechanisms	4
Comet-FISH analysis of urothelial cells. A screening opportunity for bladder cancer?	4
Research advancement in fluid biomarkers for Parkinson’s disease	4
Evaluation of ctDNA-based ESR1 testing in breast cancer: results from the first external quality assessment scheme in China	4
Clinical utilization of airway inflammatory biomarkers in the prediction and monitoring of clinical outcomes in patients with chronic obstructive pulmonary disease	4
We have reached single-visit testing, diagnosis, and treatment for hepatitis C infection, now what?	4
Gestational trophoblastic disease: STR genotyping for precision diagnosis	4
Next generation immuno-oncology biomarkers in gastrointestinal cancer: what does the future hold?	4
Genetic variant in LncRNA-NKILA associated with gastric cancer susceptibility and the binding with miR-6731-5p	4
Are we closer to robust predictors of recurrent pregnancy loss by means of integrating different types of omics data?	4
Predictive biomarkers for systemic therapy of hepatocellular carcinoma	4
Blood soluble Fas concentrations and ischemic stroke patient mortality	4
[ 68 Ga]PSMA-11 for positron emission tomography (PET) imaging of prostate-specific membrane antigen (PSMA)-positive lesions in men with prostate cancer	4
Villin expression in human tumors: a tissue microarray study on 14,398 tumors	3
Primary open-angle glaucoma: a perspective from plasma metabolomics	3
Applications of ctDNA testing to monitor and detect residual disease in breast cancer	3
Circulating microRNA biomarkers in melanoma and non-melanoma skin cancer	3
How can we improve the successful identification of patients suitable for CAR-T cell therapy?	3
A review of the value of point-of-care testing for community-acquired pneumonia	3
Diagnosis of COVID-19: hemagglutinin-esterase gene is used for molecular assays?	3
Point-of-care testing for viral-associated pulmonary aspergillosis	3
Perspective: cell death mechanisms and early diagnosis as precondition for disease modification in Parkinson’s disease: are we on the right track?	3
Overview of point-of-care diagnostic options for detection of chlamydia trachomatis : current technology and implementation considerations	3
Clinical utility of reproductive carrier screening for preconception and pregnant couples for multiple genetic conditions: a systematic review and meta-analysis	3
Clinical value of identifying genes that inhibit hepatocellular carcinomas	3
Brain exosomes as minuscule information hub for Autism Spectrum Disorder	3
Research tests for the diagnosis of tuberculosis infection	3
Diagnosis and management of invasive fungal diseases by next-generation sequencing: are we there yet?	3
Serum Fas levels during first week of sepsis are associated with severity and mortality	3
Emerging prognostic biomarkers in advanced cutaneous melanoma: a literature update	3
Serum Sema7A is increased in patients with acute aortic dissection	3
Analytical and clinical validation of an RNA sequencing-based assay for quantitative, accurate evaluation of a molecular signature response classifier in rheumatoid arthritis	3
Circulating tumor cells as prognostic biomarkers in breast cancer: current status and future prospects	3
Association between the first and second trimester cell free DNA fetal fraction and spontaneous preterm birth	3
Advances in tests for colorectal cancer screening and diagnosis	3
Gastrin-releasing peptide receptor agonists and antagonists for molecular imaging of breast and prostate cancer: from pre-clinical studies to translational perspectives	3
Smaller, cheaper, faster: where next for liquid biopsies?	3
Evaluation of transcriptomic molecular classification, biological behavior, and clinicopathological features in hepatocellular carcinoma	3
Quantifying SARS-CoV-2 viral load: current status and future prospects	3
Current status of diagnostic assays for emerging zoonotic viruses: Nipah and Hendra	3
Implementing Individualized quality control plans and managing risk at the point-of-care for molecular diagnostics	3
The diagnosis of Huntington’s disease by different molecular tools: a systematic review	3
The game changer: UCH-L1 and GFAP-based blood test as the first marketed in vitro diagnostic test for mild traumatic brain injury	3
Molecular biomarkers of blunt cardiac injury: recent advances and future perspectives	3