Expert Review of Molecular Diagnostics

Article	Citations
Do small RNAs have potential in disease diagnosis and treatment?	47
Advances and required improvements in methods to diagnosing Clostridioides difficile infections in the healthcare setting	44
Association betweenCDH1methylation and esophageal cancer risk: a meta-analysis and bioinformatics study	44
Survival Outcome and Clinicopathologicl analysis of Homeobox gene cluster-embedded LncRNAs in Human Cancers: A Systematic Review and Meta-analysis	42
Predictive biomarkers and personalized pharmacotherapy	40
Molecular point-of-care testing in the community pharmacy setting: current status and future prospects	40
RT-LAMP in SARS-CoV-2 detection: point to improve primer designing and decrease molecular diagnosis pitfalls	37
Whole genome amplicon sequencing and phylogenetic analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from lineage B.1.36.27 isolated in Hong Kong	31
Development and validation of a ligand–receptor pairs signature to predict outcome and provide a therapeutic strategy in gastric cancer	26
Advances in rapid diagnostic tests for myocardial infarction patients	25
SSR4 as a prognostic biomarker and related with immune infiltration cells in colon adenocarcinoma	23
Diagnostic significance of heart-type fatty acid-binding protein as a potential biomarker to predict the mortality rate of patients with sepsis: a systematic review and meta-analysis	23
Alzheimer’s disease: a scoping review of biomarker research and development for effective disease diagnosis	23
SOWAHB polymorphisms affect thyroid cancer risk in the Chinese Han population	22
The diagnosis of central nervous system infections in resource-limited settings and the use of novel and molecular diagnostic platforms to improve diagnosis	22
Recent advances in the diagnosis monkeypox: implications for public health	22
Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa	22
An overview of point-of-care testing for infections in critically ill patients	22
Comparative evaluation of a dual-target real-time RT-PCR assay for COVID-19 diagnosis and assessment of performance in pooled saliva and nasopharyngeal swab samples	22
Point-of-care testing for viral-associated pulmonary aspergillosis	22
Retrospective analysis of persistent HyperCKemia with or without muscle weakness in a case series from Greece highlights vast DMD variant heterogeneity	22
From biochemical markers to molecular endotypes of osteoarthritis: a review on validated biomarkers	22
Cost analyses for malaria molecular diagnosis for research planners in India and beyond	20
A state-of-the-art overview of candidate diagnostic biomarkers for Attention-deficit/hyperactivity disorder (ADHD)	20
Analytical and clinical validation of an RNA sequencing-based assay for quantitative, accurate evaluation of a molecular signature response classifier in rheumatoid arthritis	19

Improving the diagnosis of tuberculosis: old and new laboratory tools	19
Clinicopathological, etiological and molecular characteristics of intrahepatic cholangiocarcinoma subtypes classified by mucin production and immunohistochemical features	19
Optimizing testing regimes for the detection of COVID-19 in children and older adults	18
Harnessing the potential of genomic characterization of mutational profiles to improve early diagnosis of lung cancer	17
Recent updates in the development of molecular assays for the rapid identification and susceptibility testing of MRSA	17
Advances in the diagnosis of autoimmune diseases based on citrullinated peptides/proteins	17
MicroRNA-217: a therapeutic and diagnostic tumor marker	16
Molecular charcterization of lung adenocarcinoma combining whole exome sequencing, copy number analysis and gene expression profiling	16
Low-cost molecular methodology for blood group antigens identification and genotyping contribution to transfusion efficacy in multiple transfused patients	16
Oral Potentially Malignant Disorders (OPMD): What is the clinical utility of dysplasia grade?	16
Impact of non-antibiotic drugs on the human intestinal microbiome	16
Polygenic and Network-based studies in risk identification and demystification of cancer	16
The current clinical applications of preimplantation genetic testing (PGT): acknowledging the limitations of biology and technology	16
Faster infection diagnostics for intensive care unit (ICU) patients	15
Dual agonist–antagonist effect of ulipristal acetate in human endometrium and myometrium	15
Multi-omics and single-cell sequencing analyses reveal the potential significance of circadian pathways in cancer therapy	15
Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer	15
Polymerase Spiral Reaction (PSR) as a point-of-care diagnostic assay: A systematic review	15
Circulating tumor cells as prognostic biomarkers in breast cancer: current status and future prospects	15
Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers	15
Diagnostic approaches for dengue infection	15
The diagnostic and prognostic role of neutrophil-to-lymphocyte ratio in COVID-19: a systematic review and meta-analysis	14
Gene fusions in vascular tumors and their underlying molecular mechanisms	14
The prenatal exome – a door to prenatal diagnostics?	14
Evaluating tumor cell- and T cell-derived extracellular vesicles as potential biomarkers of cancer and immune cell competence	14
Characteristics of circRNA and its approach as diagnostic tool in melanoma	14
The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery	13
Diagnostic accuracy of CRISPR technology for detecting SARS-CoV-2: a systematic review and meta-analysis	13
Toward an individualized determination of dialysis adequacy: a narrative review with special emphasis on incremental hemodialysis	13
Role of N6-methyladenosine modification in pathogenesis of ischemic stroke	13
Quantitative versus qualitative estrogen and luteinizing hormone testing for personal fertility monitoring	13
Nuclease activity: an exploitable biomarker in bacterial infections	13
Diagnostic accuracy of circulating-free DNA for the determination of hepatocellular carcinoma: a systematic review and meta-analysis	12
Monitoring hepatitis B by using point-of-care testing: biomarkers, current technologies, and perspectives	12
Diagnosis of extrapulmonary tuberculosis by GeneXpert MTB/RIF Ultra assay	12
microRNAs as novel diagnostic biomarkers in endometriosis patients: a systematic review and meta-analysis	12
Spatial profiling technologies and applications for brain cancers	12
Clinical utility of reproductive carrier screening for preconception and pregnant couples for multiple genetic conditions: a systematic review and meta-analysis	12
Clinical utility of therapy selection informed by predicted nonresponse to tumor necrosis factor-ɑ inhibitors: an analysis from the Study to Accelerate Information of Molecular Signatures (AIMS) in rh	11
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer	11
Metabolomics for searching validated biomarkers in cancer studies: a decade in review	11
Analytical validation of a novel multi-target blood-based test to detect hepatocellular carcinoma	11
Serum biomarkers for predicting microvascular complications of diabetes mellitus	11
Prognostic biomarkers in melanoma: a 2023 update from clinical trials in different therapeutic scenarios	10
Brain tumors and circulating micrornas: a systematic review and diagnostic meta-analysis	10
Retrospective analysis of the risk factors associated with failure in obtaining effective noninvasive prenatal test results and pregnancy outcomes: a case-control study	10
Viral metagenomic sequencing in the diagnosis of meningoencephalitis: a review of technical advances and diagnostic yield	10
The tumor immune microenvironment in pancreatic cancer and its potential in the identification of immunotherapy biomarkers	10
An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure	10
The combined use of D-dimer testing and the neutrophil-to-lymphocyte ratio in the early differential diagnosis of aortic dissection	9

Early detection of carcinoma: correlating quantifiable tumor biomarkers with High-Resolution Microscopy (HRME) findings	9
Smart and connected devices in point-of-care molecular diagnostics: what role can they play in the response to COVID-19?	9
Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors – A systematic review	9
Application of selected biosensor techniques in clinical diagnostics	9
Diagnostic utility of rapid sequencing in critically ill infants: a systematic review and meta-analysis	9
Identifying and clinically validating biomarkers for immunotherapy in colorectal cancer	9
An overview of using fungal DNA for the diagnosis of invasive mycoses	9
Cytokeratin 18 in nonalcoholic fatty liver disease: value and application	9
A profile of the binx health io® molecular point-of-care test for chlamydia and gonorrhea in women and men	9
Molecular testing as a tool to combat the COVID-19 pandemic	9
Can the diagnostics of hepatitis in pregnant patients be improved?	8
Development and evaluation of cancer differentiation analysis technology: a novel biophysics-based cancer screening method	8
RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?	8
Diagnostic accuracy of clinically applied nanoparticle-based biosensors at detecting SARS-CoV-2 RNA and surface proteins in pharyngeal swabs compared to RT-PCR as a reference test	8
Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology	8
Borderline SARS-CoV-2 patients: the trace behind	8
Nonalcoholic fatty liver disease: use of diagnostic biomarkers and modalities in clinical practice	8
Dysregulation of lncRNA-H19 in cardiometabolic diseases and the molecular mechanism involved : a systematic review	8
Challenges in diagnosing hydatidiform moles: a review of promising molecular biomarkers	8
Targeted RNA-sequencing for the evaluation of gene fusions in lung tumors: current status and future prospects	8
Improving laboratory diagnostics in myasthenia gravis	8
COVID-19 diagnosis: lessons to learn and hints for preparedness	8
Elements of liquid biopsies: isolation, analysis, and clinical application in cancer diagnosis to prognosis	7
HNF1B polymorphisms and endometrial cancer risk: validation of identified loci and evaluation of novel variants	7
Promising biomarkers of Kawasaki disease: markers that aid in diagnosis	7
Reply to letter entitled ‘Diagnosis of COVID-19: hemagglutinin-esterase gene is used for molecular assays?’	7
Serum Sema7A is increased in patients with acute aortic dissection	7
Molecular sequencing technologies in the diagnosis and management of prosthetic joint infections	7
Molecular and epigenetic mechanisms governing ocular surface squamous neoplasia: opportunities for diagnostics	7
Genetic-based diagnostics of Parkinson’s disease and other Parkinsonian syndromes	7
Diagnosis of COVID-19: hemagglutinin-esterase gene is used for molecular assays?	7
Perspective: cell death mechanisms and early diagnosis as precondition for disease modification in Parkinson’s disease: are we on the right track?	7
Potential role of circulating miR-21 in the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis	7
Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations	7
The potential utility of smell testing to screen for neurodegenerative disorders	7
Implementation of molecular diagnostic testing for group A streptococcal pharyngitis: considerations and challenges with a focus on point-of-care environments	7
Unlocking the power of biomarkers: transforming the diagnosis of acute respiratory distress syndrome	7
An updated review of the role of lncRNAs and their contribution in various molecular subtypes of breast cancer	7
Investigation of the clinicopathological and prognostic role of circMTO1 in multiple cancers	7
MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review	7
Sample-to-result molecular diagnostic platforms and their suitability for infectious disease testing in low- and middle-income countries	6
Diagnostic accuracy of serum derived exosomes for hepatocellular carcinoma: a systematic review and meta-analysis	6
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers	6
Updates in diagnosing polycystic ovary syndrome-related infertility	6
Liquid biopsy from research to clinical practice: focus on non-small cell lung cancer	6
The current and future applications of in situ hybridization technologies in anatomical pathology	6
The diagnostic and prognostic value of tsRNAs in gastric cancers: a systematic review and meta-analysis	6
The biomolecular corona of extracellular nanoparticles holds new promises for advancing clinical molecular diagnostics	6
Virtual tissue staining in pathology using machine learning	6
Tumor treating fields: a comprehensive overview of the underlying molecular mechanism	6
The impact of the COVID-19 pandemic on addressing common barriers to pharmacy-based point-of-care testing	6
Molecular biomarkers of diffuse axonal injury: recent advances and future perspectives	6
Future potential of Rapid Acceleration of Diagnostics (RADx Tech) in molecular diagnostics	6
Application of perovskites in bioimaging: the state-of-the-art and future developments	6
The expression and mutation of BRCA1/2 genes in ovarian cancer: a global systematic study	6
The clinical application of metagenomic next-generation sequencing for detecting pathogens in bronchoalveolar lavage fluid: case reports and literature review	6
Biomarkers to guide immunomodulatory treatment: where do we stand?	5
Required improvements for cerebrospinal fluid-based biomarker tests of Alzheimer’s disease	5
We have reached single-visit testing, diagnosis, and treatment for hepatitis C infection, now what?	5
α-synuclein as an emerging pathophysiological biomarker of Alzheimer’s disease	5
Strengths and limitations of molecular diagnostics for Pneumocystis jirovecii pneumonia	5
Metabolomics-based predictive biomarkers of radiation injury and countermeasure efficacy: current status and future perspectives	5
Enhanced mitochondrial genome analysis: bioinformatic and long-read sequencing advances and their diagnostic implications	5
Maintaining point of care testing capacity and pandemic preparedness in the post-COVID-19 era	5
Functional proteomic analysis, a missing piece for understanding clonal evolution and cooperation in the tissue microecology	5
Extra-pulmonary applications of procalcitonin: an updated literature review	5
Enzymatic cross-linking of collagens in organ fibrosis – resolution and assessment	5
Implementing Individualized quality control plans and managing risk at the point-of-care for molecular diagnostics	5
Advances in gold nanoparticle technology as a tool for diagnostics and treatment of cancer	5
Evaluation of molecular techniques to visceral leishmaniasis detection in asymptomatic patients: a systematic review	5
Practical considerations for pathological diagnosis and molecular profiling of cholangiocarcinoma: an expert review for best practices	5
Advancements in protein glycosylation biomarkers for ovarian cancer through mass spectrometry-based approaches	5
Clinical application of circulating tumor DNA in metastatic cancers	5
Clinicopathological and prognostic significance of XPO1 in solid tumors: meta-analysis and TCGA analysis	5
The MALAT1-breast cancer interplay: insights and implications	5
Lipid-associated GWAS loci as important markers of the risk, severity, and clinical course of peripheral artery disease	5
Assessment of MeMed BV assays for differentiating between bacterial and viral respiratory infections	5
Can immuno-PCR (IPCR) transform bacterial disease diagnostics?	5
A novel anoikis-related signature predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma	5
A sandwich chemiluminescent magnetic microparticle immunoassay for cryptococcal antigen detection	5

Statement of Retraction	4
Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis	4
Site-specific protein biomarkers in gastric cancer: a comprehensive review of novel biomarkers and clinical applications	4
CEMIP as a prognostic biomarker for cancers: a meta- and bioinformatic analysis	4
The impact of next-generation sequencing for diagnosis and disease understanding of myeloid malignancies	4
Antimicrobial resistance prediction in Neisseria gonorrhoeae: current status and future prospects	4
Association between NUDT17 polymorphisms and breast cancer risk	4
How our molecular understanding of the pathogenesis of Mycobacterium ulcerans infection can improve diagnosis of Buruli ulcer	4
Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: racial, ethnic, and geographical considerations	4
Revisiting social MPE: an integration of molecular pathological epidemiology and social science in the new era of precision medicine	4
An evaluation of the AggreGuide A-100 ADP Assay for measuring the effect of antiplatelet agents targeting the P2Y12 receptor	4
JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence	4
Clinical utilization of airway inflammatory biomarkers in the prediction and monitoring of clinical outcomes in patients with chronic obstructive pulmonary disease	4
An overview of circulating and urinary biomarkers capable of predicting the transition of acute kidney injury to chronic kidney disease	4
How to effectively utilize imaging in disease-modifying treatments for osteoarthritis clinical trials: the radiologist’s perspective	4
Recent advances in the diagnosis of COVID-19: a bird’s eye view	4
Highlighting and addressing barriers to widespread adaptation of HIV self-testing in the United States	4
Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers	4
Potential of CRISPR/Cas system in the diagnosis of COVID-19 infection	4
Highly sensitive droplet digital PCR-based diagnostics for the surveillance of malaria vector populations in low transmission and incipient resistance settings	4
Noninvasive prenatal screening in southeast China: clinical application and accuracy evaluation	4
Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma	4
[ 68 Ga]PSMA-11 for positron emission tomography (PET) imaging of prostate-specific membrane antigen (PSMA)-positive lesions in men with prostate cancer	4
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease	4
Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases	4
Next generation immuno-oncology biomarkers in gastrointestinal cancer: what does the future hold?	4
Human tear fluid analysis for clinical applications: progress and prospects	3
Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma	3
A review on current diagnostic techniques for COVID-19	3
Noninvasive detection of COPD and Lung Cancer through breath analysis using MOS Sensor array based e-nose	3
Evaluation of the Onclarity HPV assay on the high-throughput COR system	3
Blood soluble Fas concentrations and ischemic stroke patient mortality	3
An update on our ability to monitor castration-resistant prostate cancer dynamics with cell-free DNA	3
Diagnosis for COVID-19: current status and future prospects	3
Searching for DNA methylation in patients triple-negative breast cancer: a liquid biopsy approach	3
Neuroimaging with PET/CT in chronic traumatic encephalopathy: what nuclear medicine can do to move the field forward	3
Detection of SARS-CoV-2 in tissue: the comparative roles of RT-qPCR, in situ RNA hybridization, and immunohistochemistry	3
Common markers of testicular Sertoli cells	3
Known biomarkers for monitoring pregnancy complications	3
Genetic risk and gastric cancer: polygenic risk scores in population-based case-control study	3
Molecular determination of insect venom allergies	3
Pathology-supported genetic testing for the application of breast cancer pharmacodiagnostics: family counselling, lifestyle adjustments and change of medication	3
An overview of early genetic predictors of IgA deficiency	3
Recent developments in wearable & non-wearable point-of-care biosensors for cortisol detection	3
Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers	3
Current and future strategies for diagnostic and management of obstructive sleep apnea	3
Radiomics and theranostics with molecular and metabolic probes in prostate cancer: toward a personalized approach	3
Clinical application of noninvasive prenatal testing in twin pregnancies: a single-center experience	3
Combined exome analysis and exome depth assessment achieve a high diagnostic yield in an epilepsy case series, revealing significant genomic heterogeneity and novel mechanisms	3
An overview of advancement in aptasensors for influenza detection	3
The diagnostic accuracy of seven commercial molecular in vitro SARS-CoV-2 detection tests: a rapid meta-analysis	2
A systematic review and meta-analysis combined with bioinformatic analysis on the predictive value of E-cadherin in patients with renal cell carcinoma	2
The potential diagnostic value of extracellular vesicle miRNA for human non-small cell lung cancer: a systematic review and meta-analysis	2
Rapid metagenomics for diagnosis of bloodstream and respiratory tract nosocomial infections: current status and future prospects	2
Construction of a 5-methylcytosine-Related Molecular Signature to Inform the Prognosis and Immunotherapy of Lung Squamous Cell Carcinoma	2
Point-of-care tests: the key to reducing antibiotic prescribing for respiratory tract infections in primary care?	2
Promotor methylation in ocular surface squamous neoplasia development: epigenetics implications in molecular diagnosis	2
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers	2
Gestational trophoblastic disease: STR genotyping for precision diagnosis	2
How reliable are polygenic risk scores for risk prediction in patients with heart disease?	2
Biomarkers of treatment response in bladder cancer	2
The role of fecal biomarkers in individuals with inflammatory bowel disease	2
Advances in RT-LAMP for COVID-19 testing and diagnosis	2
ASSURED-SQVM diagnostics for COVID-19: addressing the why, when, where, who, what and how of testing	2
Fortifying the diagnostic-frontiers with nanoscale technology amidst the COVID-19 catastrophe	2
A case for non-coding RNA as a suitable biomarker of amyotrophic lateral sclerosis	2
Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortality	2
The value of companion diagnostics in oncology drug development	2
Trends in molecular diagnostics: 12th European Meeting on Molecular Diagnostics, Noordwijk aan Zee, the Netherlands, 12-14 October 2022	2
Are T cell repertoires useful as diagnostics for SARS- CoV- 2 infection?	2
Relationship between diagnostic accuracy of microRNAs for NSCLC and number of combined microRNAs: an overview with meta-analysis	2
Early Identification of Fungal and Mycobacterium Infections in Pulmonary Granulomas Using Metagenomic Next-Generation Sequencing on Formalin fixation and paraffin embedding tissue	2
Comet-FISH analysis of urothelial cells. A screening opportunity for bladder cancer?	2
Research advancement in fluid biomarkers for Parkinson’s disease	2
Tumor-infiltrating lymphocytes as a prognostic and predictive factor for Melanoma	2
Molecular imaging of PARP in cancer: state-of-the-art	2
Implementing next-generation sequencing for diagnosis and management of hereditary hearing impairment: a comprehensive review	2
Body fluid markers for multiple sclerosis and differential diagnosis from atypical demyelinating disorders	2
Molecular monitoring of patient response to painkiller drugs	2
Predictive biomarkers for systemic therapy of hepatocellular carcinoma	2
Determining the accuracy of next generation sequencing based copy number variation analysis in Hereditary Breast and Ovarian Cancer	2
Recent advances in rapid antimicrobial susceptibility testing systems	2
Statistical determination of cancer biomarkers: moving forward clinically	2
The impact of companion diagnostic testing on medical decision making and IVD regulations	2
Impact of the COVID-19 pandemic on Molecular Diagnostics	2
Critical insight into recombinase polymerase amplification technology	2
Association between serum concentrations of anti-apoptotic B-cell lymphoma-2 protein and traumatic brain injury mortality	2
A stroll through the present and future of testicular germ cell tumour biomarkers	2