Lab on a Chip

Article	Citations
Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature	164
Point-of-care testing detection methods for COVID-19	163
An outlook on microfluidics: the promise and the challenge	138
Conventional and emerging strategies for the fabrication and functionalization of PDMS-based microfluidic devices	125
High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows	120
Single-cell microfluidic impedance cytometry: from raw signals to cell phenotypes using data analytics	114
A microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay for rapid COVID-19 detection	108
Engineering neurovascular organoids with 3D printed microfluidic chips	89
Accelerating innovation and commercialization through standardization of microfluidic-based medical devices	76
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures	74
Recent innovations in cost-effective polymer and paper hybrid microfluidic devices	71
Anin vitrovascularized micro-tumor model of human colorectal cancer recapitulatesin vivoresponses to standard-of-care therapy	68
HiPSC-derived multi-organoids-on-chip system for safety assessment of antidepressant drugs	65
Controllable fusion of human brain organoids using acoustofluidics	63
Simulating drug concentrations in PDMS microfluidic organ chips	61
Standardisation needs for organ on chip devices	60
Microfluidic-based capture and release of cancer-derived exosomes via peptide–nanowire hybrid interface	59
Understanding and improving FDM 3D printing to fabricate high-resolution and optically transparent microfluidic devices	57
Autonomous lab-on-paper for multiplexed, CRISPR-based diagnostics of SARS-CoV-2	56
Multiphysics microfluidics for cell manipulation and separation: a review	53
A flux-adaptable pump-free microfluidics-based self-contained platform for multiplex cancer biomarker detection	53
A high-throughput multiplexed microfluidic device for COVID-19 serology assays	53
Microfluidic technologies for nanoparticle formation	52
A thread/fabric-based band as a flexible and wearable microfluidic device for sweat sensing and monitoring	52
Machine learning for microfluidic design and control	52

Neural network-enhanced real-time impedance flow cytometry for single-cell intrinsic characterization	51
Developing an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions	51
Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices	50
Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?	50
Printed microfluidic sweat sensing platform for cortisol and glucose detection	48
The acoustic droplet printing of functional tumor microenvironments	48
Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out	48
Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure	47
Thin-film-transistor digital microfluidics for high value in vitro diagnostics at the point of need	46
Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications	46
“One-to-three” droplet generation in digital microfluidics for parallel chemiluminescence immunoassays	45
Nanoparticle protein corona: from structure and function to therapeutic targeting	45
Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth	45
Bubbles in microfluidics: an all-purpose tool for micromanipulation	45
Tubular human brain organoids to model microglia-mediated neuroinflammation	44
Materials and methods for droplet microfluidic device fabrication	44
Speeding up reconstruction of 3D tomograms in holographic flow cytometry via deep learning	43
Biomedical optical fibers	43
High throughput transepithelial electrical resistance (TEER) measurements on perfused membrane-free epithelia	43
Liquid marble-based digital microfluidics – fundamentals and applications	43
Label-free microfluidic cell sorting and detection for rapid blood analysis	43
3D printed microfluidics: advances in strategies, integration, and applications	42
Self-powered droplet manipulation system for microfluidics based on triboelectric nanogenerator harvesting rotary energy	42
Plasmonic nanobowtiefluidic device for sensitive detection of glioma extracellular vesicles by Raman spectrometry	41
Inertial microfluidics: current status, challenges, and future opportunities	41
Liver organ-on-chip models for toxicity studies and risk assessment	41
Advances in microfluidic extracellular vesicle analysis for cancer diagnostics	40
Fiber optic hydrogen sensor based on a Fabry–Perot interferometer with a fiber Bragg grating and a nanofilm	40
Interfacing cells with organic transistors: a review ofin vitroandin vivoapplications	39
Unconventional acoustic approaches for localized and designed micromanipulation	39
Point-of-care diagnostics: recent developments in a pandemic age	39
Tumor-on-a-chip platforms to study cancer–immune system crosstalk in the era of immunotherapy	38
User-friendly image-activated microfluidic cell sorting technique using an optimized, fast deep learning algorithm	37
Microliter ultrafast centrifuge platform for size-based particle and cell separation and extraction using novel omnidirectional spiral surface acoustic waves	37
Biologically inspired micro-robotic swimmers remotely controlled by ultrasound waves	36
Nonlinear microfluidics: device physics, functions, and applications	36
Simple and fast isolation of circulating exosomes with a chitosan modified shuttle flow microchip for breast cancer diagnosis	36
Microscopic artificial cilia – a review	36
Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating	35
Intelligent acoustofluidics enabled mini-bioreactors for human brain organoids	35
Direct isolation of circulating extracellular vesicles from blood for vascular risk profiling in type 2 diabetes mellitus	35
Simultaneous single-cell phenotype analysis of hepatocellular carcinoma CTCs using a SERS-aptamer based microfluidic chip	35
Retinal organoids on-a-chip: a micro-millifluidic bioreactor for long-term organoid maintenance	35
A 3D human adipose tissue model within a microfluidic device	35
Lateral flow assays for hormone detection	34
Deciphering impedance cytometry signals with neural networks	34
Gear-shaped micromixer for synthesis of silica particles utilizing inertio-elastic flow instability	34
Ultraviolet-induced in situ gold nanoparticles for point-of-care testing of infectious diseases in loop-mediated isothermal amplification	34
Cascaded filter deterministic lateral displacement microchips for isolation and molecular analysis of circulating tumor cells and fusion cells	34
A multilayered blood vessel/tumor tissue chip to investigate T cell infiltration into solid tumor tissues	34

Microdissected “cuboids” for microfluidic drug testing of intact tissues	34
Submicron-precision particle characterization in microfluidic impedance cytometry with double differential electrodes	34
Rapid and precise tumor cell separation using the combination of size-dependent inertial and size-independent magnetic methods	33
Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation	33
A portable, 3D printed, microfluidic device for multiplexed, real time, molecular detection of the porcine epidemic diarrhea virus, transmissible gastroenteritis virus, and porcine deltacoronavirus at	33
Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy	33
Tailored point-of-care biosensors for liquid biopsy in the field of oncology	33
Construction of a high fidelity epidermis-on-a-chip for scalable in vitro irritation evaluation	33
Interstitial flow enhances the formation, connectivity, and function of 3D brain microvascular networks generated within a microfluidic device	33
A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis	33
Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer	32
An integrated microfluidic system for early detection of sepsis-inducing bacteria	32
Sensing morphogenesis of bone cells under microfluidic shear stress by holographic microscopy and automatic aberration compensation with deep learning	32
Fabrication of tunable, high-molecular-weight polymeric nanoparticles via ultrafast acoustofluidic micromixing	32
Review: tomographic imaging flow cytometry	32
Review of microfluidic approaches for fabricating intelligent fiber devices: importance of shape characteristics	32
A digital protein microarray for COVID-19 cytokine storm monitoring	31
A microfluidic cathodic photoelectrochemical biosensor chip for the targeted detection of cytokeratin 19 fragments 21-1	31
Microneedle-based transdermal detection and sensing devices	31
Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers	31
Real-time isothermal DNA amplification monitoring in picoliter volumes using an optical fiber sensor	31
An electricity- and instrument-free infectious disease sensor based on a 3D origami paper-based analytical device	31
Establishment of a human three-dimensional chip-based chondro-synovial coculture joint model for reciprocal cross talk studies in arthritis research	31
Recent microfluidic advances in submicron to nanoparticle manipulation and separation	30
In vitro assay for single-cell characterization of impaired deformability in red blood cells under recurrent episodes of hypoxia	30
Fabrication of monodisperse alginate microgel beads by microfluidic picoinjection: a chelate free approach	30
Recent advances in lab-on-paper diagnostic devices using blood samples	30
Automated biophysical classification of apoptotic pancreatic cancer cell subpopulations by using machine learning approaches with impedance cytometry	30
A fully transparent, flexible PEDOT:PSS–ITO–Ag–ITO based microelectrode array for ECoG recording	30
A simple and reversible glass–glass bonding method to construct a microfluidic device and its application for cell recovery	30
Microfluidic channel integrated with a lattice lightsheet microscopic system for continuous cell imaging	30
Immuno-biosensor on a chip: a self-powered microfluidic-based electrochemical biosensing platform for point-of-care quantification of proteins	29
Recent advances in integrated solid-state nanopore sensors	29
FertDish: microfluidic sperm selection-in-a-dish for intracytoplasmic sperm injection	29
Tuning particle inertial separation in sinusoidal channels by embedding periodic obstacle microstructures	29
Investigations on T cell transmigration in a human skin-on-chip (SoC) model	29
A rapid nucleic acid concentration measurement system with large field of view for a droplet digital PCR microfluidic chip	29
Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies	29
A 3-dimensional microfluidic platform for modeling human extravillous trophoblast invasion and toxicological screening	29
Wearable chem-biosensing devices: from basic research to commercial market	29
A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology	29
Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion	28
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips	28
A sample-to-answer, quantitative real-time PCR system with low-cost, gravity-driven microfluidic cartridge for rapid detection of SARS-CoV-2, influenza A/B, and human papillomavirus 16/18	28
Recent progress on wearable point-of-care devices for ocular systems	28
A review on microrobots driven by optical and magnetic fields	27
Inertial focusing of circulating tumor cells in whole blood at high flow rates using the microfluidic CTCKey™ device for CTC enrichment	27
A graphene oxide coated tapered microfiber acting as a super-sensor for rapid detection of SARS-CoV-2	27
Rapid nitrate determination with a portable lab-on-chip device based on double microstructured assisted reactors	27
Microfluidic-based in vitro thrombosis model for studying microplastics toxicity	27
3-D swimming microdrone powered by acoustic bubbles	27
Enzyme-based digital bioassay technology – key strategies and future perspectives	27
Bacterial classification and antibiotic susceptibility testing on an integrated microfluidic platform	27
Slip formation of a high-density droplet array for nucleic acid quantification by digital LAMP with a random-access system	27
Three-dimensional imaging on a chip using optofluidics light-sheet fluorescence microscopy	26
Acoustic valves in microfluidic channels for droplet manipulation	26
Engineering a deformation-free plastic spiral inertial microfluidic system for CHO cell clarification in biomanufacturing	26
Microfluidic formation of crystal-like structures	26
Emerging point-of-care technologies for anemia detection	26
Zigzag microchannel for rigid inertial separation and enrichment (Z-RISE) of cells and particles	26
Microfluidic point-of-care device for detection of early strains and B.1.1.7 variant of SARS-CoV-2 virus	26
Measuring barrier function in organ-on-chips with cleanroom-free integration of multiplexable electrodes	25
Disposable photonics for cost-effective clinical bioassays: application to COVID-19 antibody testing	25
Cancer drug screening with an on-chip multi-drug dispenser in digital microfluidics	25
Integration of segmented microflow chemistry and online HPLC/MS analysis on a microfluidic chip system enabling enantioselective analyses at the nanoliter scale	25
Deep imaging flow cytometry	25
Postoperative evaluation of tumours based on label-free acoustic separation of circulating tumour cells by microstreaming	25
Multi-oscillation microrheology via acoustic force spectroscopy enables frequency-dependent measurements on endothelial cells at high-throughput	25
High-throughput and label-free enrichment of malignant tumor cells and clusters from pleural and peritoneal effusions using inertial microfluidics	25
Isolation and recovery of extracellular vesicles using optically-induced dielectrophoresis on an integrated microfluidic platform	24
Microfluidic droplet-based functional materials for cell manipulation	24
On-chip rapid drug screening of leukemia cells by acoustic streaming	24
Oxygen control: the often overlooked but essential piece to create betterin vitrosystems	24
Assessing red blood cell deformability from microscopy images using deep learning	24
Flowmetering for microfluidics	24
Tunnel dielectrophoresis for ultra-high precision size-based cell separation	24
A microfluidic chip with a serpentine channel enabling high-throughput cell separation using surface acoustic waves	24
Application of a gut–liver-on-a-chip device and mechanistic modelling to the quantitative in vitro pharmacokinetic study of mycophenolate mofetil	24
Cell-sorting centrifugal microfluidic chip with a flow rectifier	24
Predicting the fluid behavior of random microfluidic mixers using convolutional neural networks	24

A microfluidic device enabling deterministic single cell trapping and release	24
A continuous flow PCR array microfluidic chip applied for simultaneous amplification of target genes of periodontal pathogens	23
Recent advances in microfluidic devices for single-cell cultivation: methods and applications	23
Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform	23
On the acoustically induced fluid flow in particle separation systems employing standing surface acoustic waves – Part I	23
Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants	23
Size-tuneable isolation of cancer cells using stretchable inertial microfluidics	23
Closed-loop feedback control of microfluidic cell manipulation via deep-learning integrated sensor networks	23
Technologies for measuring red blood cell deformability	23
A microfluidic cartridge for fast and accurate diagnosis of Mycobacterium tuberculosis infections on standard laboratory equipment	23
Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array	23
Machine learning assisted fast prediction of inertial lift in microchannels	23
A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β3 impact breast cancer cell extravasation	23
Automated sample-to-answer centrifugal microfluidic system for rapid molecular diagnostics of SARS-CoV-2	23
Rapid isolation of circulating cancer associated fibroblasts by acoustic microstreaming for assessing metastatic propensity of breast cancer patients	22
An “occlusive thrombosis-on-a-chip” microfluidic device for investigating the effect of anti-thrombotic drugs	22
A fully integrated biomimetic microfluidic device for evaluation of sperm response to thermotaxis and chemotaxis	22
High-throughput injection molded microfluidic device for single-cell analysis of spatiotemporal dynamics	22
Engineering inclined orientations of piezoelectric films for integrated acoustofluidics and lab-on-a-chip operated in liquid environments	22
Label-free inertial-ferrohydrodynamic cell separation with high throughput and resolution	22
Multiplex amplification of target genes of periodontal pathogens in continuous flow PCR microfluidic chip	22
Spatial trans-epithelial electrical resistance (S-TEER) integrated in organs-on-chips	22
Advances in droplet digital polymerase chain reaction on microfluidic chips	22
Focused surface acoustic wave locally removes cells from culture surface	22
Microfluidic model with air-walls reveals fibroblasts and keratinocytes modulate melanoma cell phenotype, migration, and metabolism	22
Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research	22
Optimized design of obstacle sequences for microfluidic mixing in an inertial regime	22
Generation of flow and droplets with an ultra-long-range linear concentration gradient	22
Parallel multistep digital analysis SlipChip demonstrated with the quantification of nucleic acid by digital LAMP-CRISPR	21
Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip	21
Dosage-controlled intracellular delivery mediated by acoustofluidics for lab on a chip applications	21
An antibiotic concentration gradient microfluidic device integrating surface-enhanced Raman spectroscopy for multiplex antimicrobial susceptibility testing	21
Human neuromuscular junction on micro-structured microfluidic devices implemented with a custom micro electrode array (MEA)	21
Surfactant-laden droplet size prediction in a flow-focusing microchannel: a data-driven approach	21
Non-small cell lung carcinoma spheroid models in agarose microwells for drug response studies	21
Versatile acoustic manipulation of micro-objects using mode-switchable oscillating bubbles: transportation, trapping, rotation, and revolution	21
Practical microcircuits for handheld acoustofluidics	20
Sheathless and high-throughput elasto-inertial bacterial sorting for enhancing molecular diagnosis of bloodstream infection	20
Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models	20
Programmable motion control and trajectory manipulation of microparticles through tri-directional symmetrical acoustic tweezers	20
Healthy and diseased in vitro models of vascular systems	20
Bridging the academic–industrial gap: application of an oxygen and pH sensor-integrated lab-on-a-chip in nanotoxicology	20
Automated fluorescence quantification of extracellular vesicles collected from blood plasma using dielectrophoresis	20
IL-2 secretion-based sorting of single T cells using high-throughput microfluidic on-cell cytokine capture	20
Deep learning detector for high precision monitoring of cell encapsulation statistics in microfluidic droplets	20
High-throughput digital pathology via a handheld, multiplexed, and AI-powered ptychographic whole slide scanner	20
Fluidic circuit board with modular sensor and valves enables stand-alone, tubeless microfluidic flow control in organs-on-chips	20
A sequentially bioconjugated optofluidic laser for wash-out-free and rapid biomolecular detection	20
Lab-in-a-pencil graphite: A 3D-printed microfluidic sensing platform for real-time measurement of antipsychotic clozapine level	20
Point-of-care microchip electrophoresis for integrated anemia and hemoglobin variant testing	20
An epidermal wearable microfluidic patch for simultaneous sampling, storage, and analysis of biofluids with counterion monitoring	20
On-chip perivascularnichesupporting stemness of patient-derived glioma cells in a serum-free, flowable culture	20
Scaffold-free generation of heterotypic cell spheroids using acoustofluidics	20
Biohybrid sensor for odor detection	20
Development of a human neuromuscular tissue-on-a-chip model on a 24-well-plate-format compartmentalized microfluidic device	20
Self-aligned sequential lateral field non-uniformities over channel depth for high throughput dielectrophoretic cell deflection	20
Microfluidics for antibiotic susceptibility testing	20
Microfluidic single-cell transcriptomics: moving towards multimodal and spatiotemporal omics	20
Microfluidic technologies for immunotherapy studies on solid tumours	20
Integrated microfluidic platform with electrohydrodynamic focusing and a carbon-nanotube-based field-effect transistor immunosensor for continuous, selective, and label-free quantification of bacteria	20
Size and density measurements of single sickle red blood cells using microfluidic magnetic levitation	19
A polymer index-matched to water enables diverse applications in fluorescence microscopy	19
Quantitative particle agglutination assay for point-of-care testing using mobile holographic imaging and deep learning	19
Extraction of small extracellular vesicles by label-free and biocompatible on-chip magnetic separation	19
Small intestinal sampling capsule for inflammatory bowel disease type detection and management	19
Lateral flow device for water fecal pollution assessment: from troubleshooting of its microfluidics using bioluminescence to colorimetric monitoring of generic Escherichia coli	19
High performance inkjet printed embedded electrochemical sensors for monitoring hypoxia in a gut bilayer microfluidic chip	19
A photofabricated honeycomb micropillar array for loss-free trapping of microfluidic droplets and application to digital PCR	19
The vascular niche in next generation microphysiological systems	19
Flexural wave-based soft attractor walls for trapping microparticles and cells	19
3D micromixer for nanoliposome synthesis: a promising advance in high mass productivity	19
Digital electrical impedance analysis for single bacterium sensing and antimicrobial susceptibility testing	19
Efficient and gentle delivery of molecules into cells with different elasticity via Progressive Mechanoporation	19
A plantar wearable pressure sensor based on hybrid lead zirconate-titanate/microfibrillated cellulose piezoelectric composite films for human health monitoring	19
Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip	19
Label-free detection and enumeration of rare circulating tumor cells by bright-field image cytometry and multi-frame image correlation analysis	19
Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy	19
Digital microfluidics for biological analysis and applications	18
Recent methods of droplet microfluidics and their applications in spheroids and organoids	18
Microfluidic quantum sensing platform for lab-on-a-chip applications	18
Microfluidic studies of hydrostatic pressure-enhanced doxorubicin resistance in human breast cancer cells	18
Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response	18
Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems	18
Bio-inspired fractal textile device for rapid sweat collection and monitoring	18
Microfluidic acoustic sawtooth metasurfaces for patterning and separation using traveling surface acoustic waves	18
Sub-micron thick liquid sheets produced by isotropically etched glass nozzles	18
A microfluidic hanging drop-based spheroid co-culture platform for probing tumor angiogenesis	18
Recent advances in high-throughput single-cell transcriptomics and spatial transcriptomics	18
Monitoring the effects of chemical stimuli on live cells with metasurface-enhanced infrared reflection spectroscopy	18
Will the next generation of chemical plants be in miniaturized flow reactors?	18
Shape-based separation of drug-treated Escherichia coli using viscoelastic microfluidics	17
Flow shear stress controls the initiation of neovascularization via heparan sulfate proteoglycans within a biomimetic microfluidic model	17
Origami paper-based sample preconcentration using sequentially driven ion concentration polarization	17
Cilo-seq: highly sensitive cell-in-library-out single-cell transcriptome sequencing with digital microfluidics	17
Label-free three-dimensional observations and quantitative characterisation of on-chip vasculogenesis using optical diffraction tomography	17